105 results on '"Travis, S.P.L."'
Search Results
2. Implementing guidelines on the prevention of opportunistic infections in inflammatory bowel disease
- Author
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Walsh, A.J., Weltman, M., Burger, D., Vivekanandarajah, S., Connor, S., Howlett, M., Radford-Smith, G., Selby, W., Veillard, A.S., Grimm, M.C., Travis, S.P.L., and Lawrance, I.C.
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- 2013
- Full Text
- View/download PDF
3. P270 Correlation between endoscopic and histological activity in ulcerative colitis using validated indices
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Irani, N.R., Wang, L.M., Collins, G.S., and Travis, S.P.L.
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- 2017
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4. OP026 Zero diagnostic yield of dysplasia in polyp adjacent biopsies for patients with inflammatory bowel disease
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Lahiff, C., Wang, L.M., Travis, S.P.L., and East, J.E.
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- 2017
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5. A unique clinical phenotype of primary sclerosing cholangitis associated with Crohn's disease
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Halliday, J.S., Djordjevic, J., Lust, M., Culver, E.L., Braden, B., Travis, S.P.L., and Chapman, R.W.G.
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- 2012
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6. Establishment of a validated central reading system for ileocolonoscopy in an academic setting
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Raine, T., Pavey, H., Qian, W., Moran, G.W., Subramanian, S., Swaby, L., Travis, S.P.L., Din, S., Irving, P.M., Lindsay, J.O., Parkes, M., and Kennedy, N.A.
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- 2022
7. The second European evidence-based Consensus on the diagnosis and management of Crohn's disease: Current management
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Dignass, A., Van Assche, G., Lindsay, J.O., Lémann, M., Söderholm, J., Colombel, J.F., Danese, S., D'Hoore, A., Gassull, M., Gomollón, F., Hommes, D.W., Michetti, P., O'Morain, C., Öresland, T., Windsor, A., Stange, E.F., and Travis, S.P.L.
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- 2010
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8. European evidence-based Consensus on the prevention, diagnosis and management of opportunistic infections in inflammatory bowel disease
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Rahier, J.F., Ben-Horin, S., Chowers, Y., Conlon, C., De Munter, P., D'Haens, G., Domènech, E., Eliakim, R., Eser, A., Frater, J., Gassull, M., Giladi, M., Kaser, A., Lémann, M., Moreels, T., Moschen, A., Pollok, R., Reinisch, W., Schunter, M., Stange, E.F., Tilg, H., Van Assche, G., Viget, N., Vucelic, B., Walsh, A., Weiss, G., Yazdanpanah, Y., Zabana, Y., Travis, S.P.L., and Colombel, J.F.
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- 2009
- Full Text
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9. Food and nutritional intake at high altitude
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Edwards, J.S.A., Travis, S.P.L., and Dinmore, A.L.
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- 1998
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10. Polygenic hazard score is associated with prostate cancer in multi-ethnic populations
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Huynh-Le, M.-P. (Minh-Phuong), Fan, C.C. (Chun Chieh), Karunamuni, R. (Roshan), Thompson, W.K. (Wesley K.), Martinez, M.E. (Maria Elena), Eeles, R. (Rosalind), Kote-Jarai, Z., Muir, K. (Kenneth), Schleutker, J. (Johanna), Pashayan, N. (Nora), Batra, J. (Jyotsna), Grönberg, H. (Henrik), Neal, D.E. (David E.), Donovan, J.L. (Jenny L.), Hamdy, F.C. (Freddie C.), Martin, R.M. (Richard M.), Nielsen, S.F. (Sune F.), Nordestgaard, B.G. (Børge), Wiklund, F. (Fredrik), Tangen, C.M. (Catherine M.), Giles, G.G. (Graham G.), Wolk, K. (Kerstin), Albanes, D. (Demetrius), Travis, S.P.L. (Simon), Blot, W.J. (William), Zheng, W. (Wei), Sanderson, M. (Maureen), Stanford, J.L. (Janet L.), Mucci, L.A. (Lorelei A.), West, C.M.L. (Catharine M. L.), Kibel, A. (Adam), Cussenot, O. (Olivier), Berndt, S.I. (Sonja), Koutros, S. (Stella), Sørensen, K.D. (Karina Dalsgaard), Cybulski, C. (Cezary), Grindedal, E.M. (Eli Marie), Menegaux, F. (Florence), Khaw, K.-T. (Kay-Tee), Park, J.Y. (Jong Y.), Ingles, S.A. (Sue), Maier, C. (Christiane), Hamilton, R.J. (Robert J.), Thibodeau, S.N. (Stephen), Rosenstein, B.S. (Barry S.), Lu, Y.-J. (Yong-Jie), Watya, S. (Stephen), Vega, A. (Ana), Kogevinas, M. (Manolis), Penney, K.L. (Kathryn L.), Huff, C. (Chad), Teixeira, M.R. (Manuel R.), Multigner, L. (Luc), Leach, R.J. (Robin J.), Cannon-Albright, L.A. (Lisa), Brenner, H. (Hermann), John, E.M. (Esther), Kaneva, R. (Radka), Logothetis, N.K. (Nikos), Floris, O.A.M., De Ruyck, K. (Kim), Pandha, H. (Hardev), Razack, A. (Azad), Newcomb, L.F. (Lisa F.), Fowke, J.H. (Jay H.), Gamulin, M. (Marija), Usmani, N. (Nawaid), Claessens, F. (Frank), Gago-Dominguez, M. (Manuela), Townsend, P.A. (Paul A.), Bush, W.S. (William S.), Roobol-Bouts, M.J. (Monique), Parent, M.-É. (Marie-Élise), Hu, J.J. (Jennifer J.), Mills, I.G. (Ian G.), Andreassen, O.A. (Ole), Dale, A.M. (Anders), Seibert, T.M. (Tyler M.), Huynh-Le, M.-P. (Minh-Phuong), Fan, C.C. (Chun Chieh), Karunamuni, R. (Roshan), Thompson, W.K. (Wesley K.), Martinez, M.E. (Maria Elena), Eeles, R. (Rosalind), Kote-Jarai, Z., Muir, K. (Kenneth), Schleutker, J. (Johanna), Pashayan, N. (Nora), Batra, J. (Jyotsna), Grönberg, H. (Henrik), Neal, D.E. (David E.), Donovan, J.L. (Jenny L.), Hamdy, F.C. (Freddie C.), Martin, R.M. (Richard M.), Nielsen, S.F. (Sune F.), Nordestgaard, B.G. (Børge), Wiklund, F. (Fredrik), Tangen, C.M. (Catherine M.), Giles, G.G. (Graham G.), Wolk, K. (Kerstin), Albanes, D. (Demetrius), Travis, S.P.L. (Simon), Blot, W.J. (William), Zheng, W. (Wei), Sanderson, M. (Maureen), Stanford, J.L. (Janet L.), Mucci, L.A. (Lorelei A.), West, C.M.L. (Catharine M. L.), Kibel, A. (Adam), Cussenot, O. (Olivier), Berndt, S.I. (Sonja), Koutros, S. (Stella), Sørensen, K.D. (Karina Dalsgaard), Cybulski, C. (Cezary), Grindedal, E.M. (Eli Marie), Menegaux, F. (Florence), Khaw, K.-T. (Kay-Tee), Park, J.Y. (Jong Y.), Ingles, S.A. (Sue), Maier, C. (Christiane), Hamilton, R.J. (Robert J.), Thibodeau, S.N. (Stephen), Rosenstein, B.S. (Barry S.), Lu, Y.-J. (Yong-Jie), Watya, S. (Stephen), Vega, A. (Ana), Kogevinas, M. (Manolis), Penney, K.L. (Kathryn L.), Huff, C. (Chad), Teixeira, M.R. (Manuel R.), Multigner, L. (Luc), Leach, R.J. (Robin J.), Cannon-Albright, L.A. (Lisa), Brenner, H. (Hermann), John, E.M. (Esther), Kaneva, R. (Radka), Logothetis, N.K. (Nikos), Floris, O.A.M., De Ruyck, K. (Kim), Pandha, H. (Hardev), Razack, A. (Azad), Newcomb, L.F. (Lisa F.), Fowke, J.H. (Jay H.), Gamulin, M. (Marija), Usmani, N. (Nawaid), Claessens, F. (Frank), Gago-Dominguez, M. (Manuela), Townsend, P.A. (Paul A.), Bush, W.S. (William S.), Roobol-Bouts, M.J. (Monique), Parent, M.-É. (Marie-Élise), Hu, J.J. (Jennifer J.), Mills, I.G. (Ian G.), Andreassen, O.A. (Ole), Dale, A.M. (Anders), and Seibert, T.M. (Tyler M.)
- Abstract
Genetic models for cancer have been evaluated using almost exclusively European data, which could exacerbate health disparities. A polygenic hazard score (PHS1) is associated with age at prostate cancer diagnosis and improves screening accuracy in Europeans. Here, we evaluate performance of PHS2 (PHS1, adapted for OncoArray) in a multi-ethnic dataset of 80,491 men (49,916 cases, 30,575 controls). PHS2 is associated with age at diagnosis of any and aggressive (Gleason score ≥ 7, stage T3-T4, PSA ≥ 10 ng/mL, or nodal/distant metastasis) cancer and prostate-cancer-specific death. Associations with cancer are significant within European (n = 71,856), Asian (n = 2,382), and African (n = 6,253) genetic ancestries (p < 10−180). Comparing the 80th/20th PHS2 percentiles, hazard ratios for prostate cancer, aggressive cancer, and prostate-cancer-specific death are 5.32, 5.88, and 5.68, respectively. Within European, Asian, and African ancestries, hazard ratios for prostate cancer are: 5.54, 4.49, and 2.54, respectively. PHS2 risk-stratifies men f
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- 2021
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11. European evidence-based Consensus on the management of ulcerative colitis: Current management
- Author
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Travis, S.P.L., Stange, E.F., Lémann, M., Øresland, T., Bemelman, W.A., Chowers, Y., Colombel, J.F., D'Haens, G., Ghosh, S., Marteau, P., Kruis, W., Mortensen, N.J.McC., Penninckx, F., and Gassull, M.
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- 2008
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12. European evidence-based Consensus on the diagnosis and management of ulcerative colitis: Definitions and diagnosis
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Stange, E.F., Travis, S.P.L., Vermeire, S., Reinisch, W., Geboes, K., Barakauskiene, A., Feakins, R., Fléjou, J.F., Herfarth, H., Hommes, D.W., Kupcinskas, L., Lakatos, P.L., Mantzaris, G.J., Schreiber, S., Villanacci, V., and Warren, B.F.
- Published
- 2008
- Full Text
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13. The CHEK2 variant C.349A>G is associated with prostate cancer risk and carriers share a common ancestor
- Author
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Brandão, A. (Andreia), Paulo, P. (Paula), Maia, S. (Sofia), Pinheiro, M. (Manuela), Peixoto, A. (Ana), Cardoso, M. (Marta), Silva, M.P. (Maria P.), Santos, C. (Catarina), Eeles, R. (Rosalind), Kote-Jarai, Z., Muir, K.R. (K.), Schleutker, J. (Johanna), Wang, Y. (Ying), Pashayan, N. (Nora), Batra, J. (Jyotsna), Grönberg, H. (Henrik), Neal, D. (David), Nordestgaard, B.G. (Børge), Tangen, C.M. (Catherine M.), Southey, M.C. (Melissa), Wolk, K. (Kerstin), Albanes, D. (Demetrius), Haiman, C.A. (Christopher), Travis, S.P.L. (Simon), Stanford, J.L. (Janet L.), Mucci, L.A. (Lorelei A.), West, C.M.L. (Catharine M. L.), Nielsen, S.F. (Sune F.), Kibel, A. (Adam), Cussenot, O. (Olivier), Berndt, S.I. (Sonja), Koutros, S. (Stella), Sørensen, K.D. (Karina Dalsgaard), Cybulski, C. (Cezary), Grindedal, E.M. (Eli Marie), Park, J.Y. (Jong Y.), Ingles, S.A. (Sue), Maier, C. (Christiane), Hamilton, R.J. (Robert J.), Rosenstein, B.S. (Barry S.), Vega, A. (Ana), Kogevinas, M. (Manolis), Wiklund, F. (Fredrik), Penney, K.L. (Kathryn L.), Brenner, H. (Hermann), John, E.M. (Esther), Kaneva, R. (Radka), Logothetis, N.K. (Nikos), Floris, O.A.M., De Ruyck, K. (Kim), Razack, A. (Azad), Newcomb, L.F. (Lisa F.), Lessel, D. (Davor), Usmani, N. (Nawaid), Claessens, F., Gago-Dominguez, M. (Manuela), Townsend, P.A. (Paul A.), Roobol-Bouts, M.J. (Monique), Teixeira, P.J., Brandão, A. (Andreia), Paulo, P. (Paula), Maia, S. (Sofia), Pinheiro, M. (Manuela), Peixoto, A. (Ana), Cardoso, M. (Marta), Silva, M.P. (Maria P.), Santos, C. (Catarina), Eeles, R. (Rosalind), Kote-Jarai, Z., Muir, K.R. (K.), Schleutker, J. (Johanna), Wang, Y. (Ying), Pashayan, N. (Nora), Batra, J. (Jyotsna), Grönberg, H. (Henrik), Neal, D. (David), Nordestgaard, B.G. (Børge), Tangen, C.M. (Catherine M.), Southey, M.C. (Melissa), Wolk, K. (Kerstin), Albanes, D. (Demetrius), Haiman, C.A. (Christopher), Travis, S.P.L. (Simon), Stanford, J.L. (Janet L.), Mucci, L.A. (Lorelei A.), West, C.M.L. (Catharine M. L.), Nielsen, S.F. (Sune F.), Kibel, A. (Adam), Cussenot, O. (Olivier), Berndt, S.I. (Sonja), Koutros, S. (Stella), Sørensen, K.D. (Karina Dalsgaard), Cybulski, C. (Cezary), Grindedal, E.M. (Eli Marie), Park, J.Y. (Jong Y.), Ingles, S.A. (Sue), Maier, C. (Christiane), Hamilton, R.J. (Robert J.), Rosenstein, B.S. (Barry S.), Vega, A. (Ana), Kogevinas, M. (Manolis), Wiklund, F. (Fredrik), Penney, K.L. (Kathryn L.), Brenner, H. (Hermann), John, E.M. (Esther), Kaneva, R. (Radka), Logothetis, N.K. (Nikos), Floris, O.A.M., De Ruyck, K. (Kim), Razack, A. (Azad), Newcomb, L.F. (Lisa F.), Lessel, D. (Davor), Usmani, N. (Nawaid), Claessens, F., Gago-Dominguez, M. (Manuela), Townsend, P.A. (Paul A.), Roobol-Bouts, M.J. (Monique), and Teixeira, P.J.
- Abstract
The identification of recurrent founder variants in cancer predisposing genes may have important implications for implementing cost-effective targeted genetic screening strategies. In this study, we evaluated the prevalence and relative risk of the CHEK2 recurrent variant c.349A>G in a series of 462 Portuguese patients with early-onset and/or familial/hereditary prostate cancer (PrCa), as well as in the large multicentre PRACTICAL case–control study comprising 55,162 prostate cancer cases and 36,147 controls. Additionally, we investigated the potential shared ancestry of the carriers by performing identity-by-descent, haplotype and age estimation analyses using high-density SNP data from 70 variant carriers belonging to 11 different populations included in the PRACTICAL consortium. The CHEK2 missense variant c.349A>G was found significantly associated with an increased risk for PrCa (OR 1.9; 95% CI: 1.1–3.2). A shared haplotype flanking the variant in all carriers was identified, strongly suggesting a common founder of European origin. Additionally, using two independent statistical algorithms, implemented by DMLE+2.3 and ESTIAGE, we were able to estimate the age of the variant between 2300 and 3125 years. By extending the haplotype analysis to 14 additional carrier families, a shared core haplotype was revealed among all carriers matching the conserved region previously identified in the high-density SNP analysis. These findings are consistent with CHEK2 c.349A>G being a founder variant associated with increased PrCa risk, suggesting its potential usefulness for cost-effective targeted genetic screening in PrCa families.
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- 2020
- Full Text
- View/download PDF
14. An integrative multi-omics analysis to identify candidate DNA methylation biomarkers related to prostate cancer risk
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Wu, L. (Lang), Yang, Y. (Yaohua), Guo, X. (Xingyi), Shu, X.-O. (Xiao-Ou), Cai, Q. (Qiuyin), Shu, X. (Xiang), Li, B. (Bingshan), Tao, R. (Ran), Wu, C. (Chong), Nikas, J.B. (Jason B.), Sun, Y. (Yanfa), Zhu, J. (Jingjing), Roobol-Bouts, M.J. (Monique), Giles, G.G. (Graham G.), Brenner, H. (Hermann), John, E.M. (Esther M.), Clements, J. (Judith), Grindedal, E.M. (Eli Marie), Park, J.Y. (Jong Y.), Stanford, J.L. (Janet L.), Kote-Jarai, Z. (Zsofia), Haiman, C.A. (Christopher), Eeles, R.A. (Rosalind A.), Zheng, W. (Wei), Long, J. (Jirong), Henderson, B.E. (Brian E.), Haiman, C.A. (Christopher A.), Kote-Jarai, Z., Schumacher, F.R. (Fredrick R), Easton, D. (Douglas), Benlloch, S. (Sara), Olama, A.A.A. (Ali Amin Al), Muir, K.R. (K.), Berndt, S.I. (Sonja I.), Conti, G. (Giario), Wiklund, F. (Fredrik), Chanock, S.J. (Stephen), Gapstur, S.M. (Susan M.), Stevens, V.L. (Victoria L.), Tangen, C.M. (Catherine M.), Batra, J. (Jyotsna), Grönberg, H. (Henrik), Pashayan, N. (Nora), Schleutker, J. (Johanna), Albanes, D. (Demetrius), Weinstein, S. (Stephanie), Wolk, K. (Kerstin), West, C. (Catharine), Mucci, L. (Lorelei), Cancel-Tassin, G. (Géraldine), Koutros, S. (Stella), Sorensen, K.D. (Karina Dalsgaard), Neal, D. (David), Hamdy, F.C. (Freddie C.), Donovan, J. (Jenny), Travis, R.C. (Ruth C.), Hamilton, R.J. (Robert J.), Ingles, S.A. (Sue), Rosenstein, B.S. (Barry S.), Lu, Y.-J. (Yong-Jie), Kibel, A. (Adam), Vega, A. (Ana), Kogevinas, M. (Manolis), Penney, K.L. (Kathryn L.), Cybulski, C. (Cezary), Nordestgaard, B.G. (Børge), Maier, C. (Christiane), Kim, J. (Jongoh), John, E.M. (Esther), Teixeira, P.J., Floris, O.A.M., De Ruyck, K. (Kim), Razack, A. (Azad), Newcomb, L.F. (Lisa F.), Gamulin, M. (Marija), Kaneva, R. (Radka), Usmani, N. (Nawaid), Claessens, F. (Frank), Townsend, P.A. (Paul A.), Dominguez, M.G. (Manuela Gago), Menegaux, F. (Florence), Khaw, K.-T. (Kay-Tee), Cannon-Albright, L.A. (Lisa), Pandha, H. (Hardev), Thibodeau, S.N. (Stephen), Hunter, D.J. (David), Blot, W.J. (William), Riboli, E. (Elio), Eeles, R. (Rosalind), Neal, D.E. (David E.), Hamdy, F. (Freddie), Donovan, J.L. (Jenny L.), Schumacher, F.R. (Fredrick R.), Berndt, S.I. (Sonja), Chanock, S. (Stephen), Travis, S.P.L. (Simon), Hunter, D.J. (David J.), Gronberg, H. (Henrik), Wu, L. (Lang), Yang, Y. (Yaohua), Guo, X. (Xingyi), Shu, X.-O. (Xiao-Ou), Cai, Q. (Qiuyin), Shu, X. (Xiang), Li, B. (Bingshan), Tao, R. (Ran), Wu, C. (Chong), Nikas, J.B. (Jason B.), Sun, Y. (Yanfa), Zhu, J. (Jingjing), Roobol-Bouts, M.J. (Monique), Giles, G.G. (Graham G.), Brenner, H. (Hermann), John, E.M. (Esther M.), Clements, J. (Judith), Grindedal, E.M. (Eli Marie), Park, J.Y. (Jong Y.), Stanford, J.L. (Janet L.), Kote-Jarai, Z. (Zsofia), Haiman, C.A. (Christopher), Eeles, R.A. (Rosalind A.), Zheng, W. (Wei), Long, J. (Jirong), Henderson, B.E. (Brian E.), Haiman, C.A. (Christopher A.), Kote-Jarai, Z., Schumacher, F.R. (Fredrick R), Easton, D. (Douglas), Benlloch, S. (Sara), Olama, A.A.A. (Ali Amin Al), Muir, K.R. (K.), Berndt, S.I. (Sonja I.), Conti, G. (Giario), Wiklund, F. (Fredrik), Chanock, S.J. (Stephen), Gapstur, S.M. (Susan M.), Stevens, V.L. (Victoria L.), Tangen, C.M. (Catherine M.), Batra, J. (Jyotsna), Grönberg, H. (Henrik), Pashayan, N. (Nora), Schleutker, J. (Johanna), Albanes, D. (Demetrius), Weinstein, S. (Stephanie), Wolk, K. (Kerstin), West, C. (Catharine), Mucci, L. (Lorelei), Cancel-Tassin, G. (Géraldine), Koutros, S. (Stella), Sorensen, K.D. (Karina Dalsgaard), Neal, D. (David), Hamdy, F.C. (Freddie C.), Donovan, J. (Jenny), Travis, R.C. (Ruth C.), Hamilton, R.J. (Robert J.), Ingles, S.A. (Sue), Rosenstein, B.S. (Barry S.), Lu, Y.-J. (Yong-Jie), Kibel, A. (Adam), Vega, A. (Ana), Kogevinas, M. (Manolis), Penney, K.L. (Kathryn L.), Cybulski, C. (Cezary), Nordestgaard, B.G. (Børge), Maier, C. (Christiane), Kim, J. (Jongoh), John, E.M. (Esther), Teixeira, P.J., Floris, O.A.M., De Ruyck, K. (Kim), Razack, A. (Azad), Newcomb, L.F. (Lisa F.), Gamulin, M. (Marija), Kaneva, R. (Radka), Usmani, N. (Nawaid), Claessens, F. (Frank), Townsend, P.A. (Paul A.), Dominguez, M.G. (Manuela Gago), Menegaux, F. (Florence), Khaw, K.-T. (Kay-Tee), Cannon-Albright, L.A. (Lisa), Pandha, H. (Hardev), Thibodeau, S.N. (Stephen), Hunter, D.J. (David), Blot, W.J. (William), Riboli, E. (Elio), Eeles, R. (Rosalind), Neal, D.E. (David E.), Hamdy, F. (Freddie), Donovan, J.L. (Jenny L.), Schumacher, F.R. (Fredrick R.), Berndt, S.I. (Sonja), Chanock, S. (Stephen), Travis, S.P.L. (Simon), Hunter, D.J. (David J.), and Gronberg, H. (Henrik)
- Abstract
It remains elusive whether some of the associations identified in genome-wide association studies of prostate cancer (PrCa) may be due to regulatory effects of genetic variants on CpG sites, which may further influence expression of PrCa target genes. To search for CpG
- Published
- 2020
- Full Text
- View/download PDF
15. Lack of association of MYO9B genetic variants with coeliac disease in a British cohort
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Hunt, K.A., Monsuur, A.J., McArdle, W.L., Kumar, P.J., Travis, S.P.L., Walters, J.R.F., Jewell, D.P., Strachan, D.P., Playford, R.J., Wijmenga, C., and van Heel, D.A.
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Celiac disease -- Genetic aspects ,Celiac disease -- Development and progression ,Celiac disease -- Risk factors ,Celiac disease -- Research ,Genetic variation -- Research ,Health - Published
- 2006
16. European evidence based consensus on the diagnosis and management of Crohn's disease: current management
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Travis, S.P.L., Stange, E.F., Lemann, M., Oresland, T., Chowers, Y., Forbes, A., D'Haens, G., Kitis, G., Cortot, A., Prantera, C., Marteau, P., Colombel, J.-F., Gionchetti, P., Bouhnik, Y., Tiret, E., Kroesen, J., Starlinger, M., and McM Mortensen, N.J.
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Practice guidelines (Medicine) -- Evaluation ,Crohn's disease -- Care and treatment ,Health - Published
- 2006
17. European evidence based consensus on the diagnsis and management of Crohn's disease: definitions and diagnosis
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Stange, E.F., Travis, S.P.L., Vermeire, S., Beglinger, C., Kupcinskas, L., Geboes, K., Barakauskiene, A., Villanacci, V., Von Herbay, A., Warren, B.F., Gasche, C., Tilg, H., Schreiber, Stefan W., Scholmerich, J., and Reinisch, W.
- Subjects
Crohn's disease -- Diagnosis ,Practice guidelines (Medicine) -- Evaluation ,Health - Published
- 2006
18. Guidelines for the management of inflammatory bowel disease in adults
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Carter, M.J., Lobo, A.J., and Travis, S.P.L.
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Inflammatory bowel diseases -- Care and treatment ,Medical care -- Standards ,Medical care -- United Kingdom ,Health - Published
- 2004
19. Immune-mediated and chronic inflammatory disease in people with sarcoidosis: disease associations in a large UK database
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Rajoriya, N., Wotton, C.J., Yeates, D.G.R., Travis, S.P.L., and Goldacre, M.J.
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Sarcoidosis -- Research ,Sarcoidosis -- Complications and side effects ,Inflammation -- Research ,Inflammation -- Risk factors ,Epidemiology -- Research ,Databases -- Usage ,CD-ROM catalog ,CD-ROM database ,Database ,Health - Published
- 2009
20. A 15-year audit of home parenteral nutrition provision at the John Radcliffe Hospital, Oxford
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Green, C.J., Mountford, V., Hamilton, H., Kettlewell, M.G.W., and Travis, S.P.L.
- Published
- 2008
21. Erratum: Publisher Correction: Shared heritability and functional enrichment across six solid cancers (Nature communications (2019) 10 1 (431))
- Author
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Jiang, X. (Xia), Finucane, H.K. (Hilary K.), Schumacher, F.R. (Fredrick R), Schmit, S.L. (Stephanie L.), Tyrer, J.P. (Jonathan P.), Han, Y. (Younghun), Michailidou, K. (Kyriaki), Lesseur, C. (Corina), Kuchenbaecker, K.B. (Karoline), Dennis, J. (Joe), Conti, G. (Giario), Casey, G. (Graham), Gaudet, M.M. (Mia M.), Huyghe, J.R. (Jeroen R.), Albanes, D. (Demetrius), Aldrich, M.C. (Melinda), Andrew, A.S. (Angeline S.), Andrulis, I.L. (Irene L.), Anton-Culver, H. (Hoda), Antoniou, A.C. (Antonis C.), Antonenkova, N.N. (Natalia N.), Arnold, S.M. (Susanne M.), Aronson, K.J. (Kristan J.), Arun, B.K. (Banu), Bandera, E.V. (Elisa), Barkardottir, R.B. (Rosa B.), Barnes, D. (Daniel), Batra, J. (Jyotsna), Beckmann, M.W. (Matthias), Benítez, J. (Javier), Benlloch, S. (Sara), Berchuck, A. (Andrew), Berndt, S.I. (Sonja), Bickeböller, H. (Heike), Bien, S.A. (Stephanie A.), Blomqvist, C. (Carl), Boccia, S. (Stefania), Bogdanova, N.V. (Natalia V.), Bojesen, S.E. (Stig), Bolla, M.K. (Manjeet K.), Brauch, H. (Hiltrud), Brenner, H. (Hermann), Brenton, J.D. (James D.), Brook, R.H., Brunet, J. (Joan), Brunnström, H. (Hans), Buchanan, D.D. (Daniel D.), Burwinkel, B. (Barbara), Butzow, R. (Ralf), Cadoni, G. (Gabriella), Caldes, T. (Trinidad), Caligo, M.A. (Maria A.), Campbell, I. (Ian), Campbell, P.T. (Peter T.), Cancel-Tassin, G. (Géraldine), Cannon-Albright, L.A. (Lisa), Campa, D. (Daniele), Caporaso, N.E. (Neil), Carvalho, A.L. (André L), Chan, A.T. (Andrew T.), Chang-Claude, J. (Jenny), Chanock, S.J. (Stephen), Chen, C. (Chu), Christiani, D.C. (David C.), Claes, K.B.M. (Kathleen B M), Claessens, F. (Frank), Clements, J. (Judith), Collée, J.M. (J Margriet), Correa, M.C. (Marcia Cruz), Couch, F.J. (Fergus), Cox, A. (Angela), Cunningham, J.M. (Julie), Cybulski, C. (Cezary), Czene, K. (Kamila), Daly, M.B. (Mary), DeFazio, A. (Anna), Devilee, P. (Peter), Diez, O. (Orland), Gago-Dominguez, M. (Manuela), Donovan, J.L. (Jenny L.), Dörk, T. (Thilo), Duell, E.J. (Eric), Dunning, A.M. (Alison M.), Dwek, M. (Miriam), Eccles, D. (Diana), Edlund, C.K. (Christopher), Edwards, D.R.V. (Digna R Velez), Ellberg, C. (Carolina), Evans, D.G. (D Gareth), Fasching, P.A. (Peter), Ferris, R.L. (Robert L.), Liloglou, T. (Triantafillos), Figueiredo, J.C. (Jane C.), Fletcher, O. (Olivia), Fortner, R.T. (Renée T), Fostira, F. (Florentia), Franceschi, S. (Silvia), Friedman, E. (Eitan), Gallinger, S. (Steve), Ganz, P.A. (Patricia), Garber, J. (Judy), García-Sáenz, J.A. (José A), Gayther, S.A. (Simon), Giles, G.G. (Graham G.), Godwin, A.K. (Andrew K.), Goldberg, M.S. (Mark), Goldgar, D.E. (David E.), Goode, E.L. (Ellen), Goodman, M.T. (Marc), Goodman, G. (Gary), Grankvist, K. (Kjell), Greene, M.H. (Mark H.), Grönberg, H. (Henrik), Gronwald, J. (Jacek), Guénel, P. (Pascal), Håkansson, N. (Niclas), Hall, P. (Per), Hamann, U. (Ute), Hamdy, F. (Freddie), Hamilton, R.J. (Robert J.), Hampe, J. (Jochen), Haugen, A. (Aage), Heitz, F. (Florian), Herrero, R. (Rolando), Hillemanns, P. (Peter), Hoffmeister, M. (Michael), Høgdall, E. (Estrid), Hong, Y.-C. (Yun-Chul), Hopper, J.L. (John), Houlston, R. (Richard), Hulick, P.J. (Peter J.), Hunter, D.J. (David), Huntsman, D.G. (David G.), Idos, G. (Gregory), Imyanitov, E.N. (Evgeny), Ingles, S.A. (Sue), Isaacs, C. (Claudine), Jakubowska, A. (Anna), James, M. (Margaret), Jenkins, M.A. (Mark A.), Johansson, M. (Mattias), Johansson, M. (Mikael), John, E.M. (Esther), Joshi, A.D. (Amit D.), Kaneva, R. (Radka), Karlan, B.Y. (Beth), Kelemen, L.E. (Linda E.), Kühl, T. (Tabea), Khaw, K.-T. (Kay-Tee), Khusnutdinova, E.K. (Elza), Kibel, A. (Adam), Kiemeney, L.A. (Lambertus A.), Kim, J. (Jongoh), Kjaer, M. (Michael), Knight, J.A. (Julia), Kogevinas, M. (Manolis), Kote-Jarai, Z., Koutros, S. (Stella), Kristensen, V. (Vessela), Kupryjanczyk, J. (Jolanta), Lacko, M. (Martin), Lam, S. (Stephan), Lambrechts, D. (Diether), Landi, M.T. (Maria Teresa), Lazarus, P. (Philip), Le, N.D. (Nhu D.), Lee, E. (Eunjung), Lejbkowicz, F. (Flavio), Lenz, H.-J. (Heinz-Josef), Leslie, G. (Goska), Lessel, D. (Davor), Lester, J. (Jenny), Levine, D.A. (Douglas), Li, L. (Li), Li, C.I. (Christopher I.), Lindblom, A. (Annika), Lindor, N.M. (Noralane), Liu, G. (Geoffrey), Loupakis, F. (Fotios), Lubinski, J. (Jan), Maehle, L., Maier, C. (Christiane), Mannermaa, A. (Arto), Le Marchand, L. (Loic), Margolin, S. (Sara), May, T. (Taymaa), McGuffog, L. (Lesley), Meindl, A. (Alfons), Middha, P. (Pooja), Miller, A. (Austin), Milne, R.L. (Roger), MacInnis, R.J. (Robert J.), Modugno, F. (Francesmary), Montagna, M. (Marco), Moreno, V. (Víctor), Moysich, K.B. (Kirsten), Mucci, L. (Lorelei), Muir, K. (Kenneth), Mulligan, A.-M. (Anna-Marie), Nathanson, K.L. (Katherine), Neal, D. (David), Ness, A.R. (Andrew R.), Neuhausen, S.L. (Susan L.), Nevanlinna, H. (Heli), Newcomb, P. (Polly), Newcomb, L.F. (Lisa F.), Nielsen, F. (Finn), Nikitina-Zake, L. (Liene), Nordestgaard, B.G. (Børge), Nussbaum, R. (Robert), Offit, K. (Kenneth), Olah, E. (Edith), Olama, A.A.A. (Ali Amin Al), Olopade, O.I. (Olofunmilayo), Olshan, A.F. (Andrew F.), Olsson, H. (Håkan), Osorio, A. (Ana), Pandha, H. (Hardev), Park, J.Y. (Jong Y.), Pashayan, N. (Nora), Parsons, M. (Marilyn), Pejovic, T. (Tanja), Penney, K.L. (Kathryn L.), Peters, W.H.M. (Wilbert), Phelan, C. (Catherine), Phipps, A.I. (Amanda I.), Plaseska-Karanfilska, D. (Dijana), Pring, M. (Miranda), Prokofyeva, D. (Darya), Radice, P. (Paolo), Stefansson, K. (Kari), Ramus, S.J. (Susan), Raskin, L. (Leon), Rennert, G. (Gad), Rennert, H.S. (Hedy S.), Rensburg, E.J. (Elizabeth) van, Riggan, M.J. (Marjorie J.), Risch, H.A. (Harvey A.), Risch, A. (Angela), Roobol, M.J. (Monique J.), Rosenstein, B.S. (Barry S.), Rossing, M.A. (Mary Anne), De Ruyck, K. (Kim), Saloustros, E. (Emmanouil), Sandler, D.P. (Dale P.), Sawyer, E.J. (Elinor J.), Schabath, M.B. (Matthew), Schleutker, J. (Johanna), Schmidt, M.K. (Marjanka), Setiawan, V.W. (V Wendy), Shen, H. (Hongbing), Siegel, E.M. (Erin M.), Sieh, W. (Weiva), Singer, C.F. (Christian), Slattery, M.L. (Martha L.), Sorensen, K.D. (Karina Dalsgaard), Southey, M.C. (Melissa), Spurdle, A.B. (Amanda), Stanford, J.L. (Janet L.), Stevens, V.L. (Victoria L.), Stintzing, S. (Sebastian), Stone, J. (Jennifer), Sundfeldt, K. (Karin), Sutphen, R. (Rebecca), Swerdlow, A.J. (Anthony ), Tajara, E.H. (Eloiza H.), Tangen, C.M. (Catherine M.), Tardón, A. (Adonina), Taylor, J.A. (Jack A.), Teare, M.D. (M Dawn), Teixeira, P.J., Terry, M.B. (Mary Beth), Terry, K.L. (Kathryn L.), Thibodeau, S.N. (Stephen), Thomassen, M. (Mads), Bjørge, L. (Line), Tischkowitz, M. (Marc), Toland, A.E. (Amanda), Torres, D. (Diana), Townsend, P.A. (Paul A.), Travis, S.P.L. (Simon), Tung, N. (Nadine), Tworoger, S. (Shelley), Ulrich, C. (Cornelia), Usmani, N. (Nawaid), Vachon, C. (Celine), Van Nieuwenhuysen, E. (Els), Vega, A. (Ana), Aguado-Barrera, M.E. (Miguel Elías), Wang, Q. (Qin), Webb, P. (Penny), Weinberg, C.R. (Clarice R.), Weinstein, S. (Stephanie), Weissler, M.C. (Mark C.), Weitzel, J.N. (Jeffrey), West, C.M.L. (Catharine M L), White, E. (Emily), Whittemore, A.S. (Alice), Wichmann, H.-E. (H-Erich), Wiklund, F. (Fredrik), Winqvist, R. (Robert), Wolk, K. (Kerstin), Woll, P.J. (Penella J), Woods, M.O. (Michael), Wu, A.H. (Anna H.), Wu, X. (Xifeng), Yannoukakos, D. (Drakoulis), Zheng, W. (Wei), Zienolddiny, S. (Shanbeh), Ziogas, A. (Argyrios), Zorn, K.K. (Kristin K.), Lane, J.M. (Jacqueline M.), Saxena, R. (Richa), Thomas, D.C. (Duncan), Hung, R.J. (Rayjean J.), Diergaarde, B. (Brenda), McKay, J. (James), Peters, U. (Ulrike), Hsu, L. (Li), García-Closas, M. (Montserrat), Eeles, R.A. (Rosalind A.), Chenevix-Trench, G. (Georgia), Brennan, P.J. (Paul J.), Haiman, C.A. (Christopher), Simard, J. (Jacques), Easton, D.F. (Douglas), Gruber, S.B. (Stephen), Pharoah, P.D.P. (Paul), Price, A.L. (Alkes L.), Pasaniuc, B. (Bogdan), Amos, C.I. (Christopher I.), Kraft, P. (Peter), Lindström, S. (Sara), Jiang, X. (Xia), Finucane, H.K. (Hilary K.), Schumacher, F.R. (Fredrick R), Schmit, S.L. (Stephanie L.), Tyrer, J.P. (Jonathan P.), Han, Y. (Younghun), Michailidou, K. (Kyriaki), Lesseur, C. (Corina), Kuchenbaecker, K.B. (Karoline), Dennis, J. (Joe), Conti, G. (Giario), Casey, G. (Graham), Gaudet, M.M. (Mia M.), Huyghe, J.R. (Jeroen R.), Albanes, D. (Demetrius), Aldrich, M.C. (Melinda), Andrew, A.S. (Angeline S.), Andrulis, I.L. (Irene L.), Anton-Culver, H. (Hoda), Antoniou, A.C. (Antonis C.), Antonenkova, N.N. (Natalia N.), Arnold, S.M. (Susanne M.), Aronson, K.J. (Kristan J.), Arun, B.K. (Banu), Bandera, E.V. (Elisa), Barkardottir, R.B. (Rosa B.), Barnes, D. (Daniel), Batra, J. (Jyotsna), Beckmann, M.W. (Matthias), Benítez, J. (Javier), Benlloch, S. (Sara), Berchuck, A. (Andrew), Berndt, S.I. (Sonja), Bickeböller, H. (Heike), Bien, S.A. (Stephanie A.), Blomqvist, C. (Carl), Boccia, S. (Stefania), Bogdanova, N.V. (Natalia V.), Bojesen, S.E. (Stig), Bolla, M.K. (Manjeet K.), Brauch, H. (Hiltrud), Brenner, H. (Hermann), Brenton, J.D. (James D.), Brook, R.H., Brunet, J. (Joan), Brunnström, H. (Hans), Buchanan, D.D. (Daniel D.), Burwinkel, B. (Barbara), Butzow, R. (Ralf), Cadoni, G. (Gabriella), Caldes, T. (Trinidad), Caligo, M.A. (Maria A.), Campbell, I. (Ian), Campbell, P.T. (Peter T.), Cancel-Tassin, G. (Géraldine), Cannon-Albright, L.A. (Lisa), Campa, D. (Daniele), Caporaso, N.E. (Neil), Carvalho, A.L. (André L), Chan, A.T. (Andrew T.), Chang-Claude, J. (Jenny), Chanock, S.J. (Stephen), Chen, C. (Chu), Christiani, D.C. (David C.), Claes, K.B.M. (Kathleen B M), Claessens, F. (Frank), Clements, J. (Judith), Collée, J.M. (J Margriet), Correa, M.C. (Marcia Cruz), Couch, F.J. (Fergus), Cox, A. (Angela), Cunningham, J.M. (Julie), Cybulski, C. (Cezary), Czene, K. (Kamila), Daly, M.B. (Mary), DeFazio, A. (Anna), Devilee, P. (Peter), Diez, O. (Orland), Gago-Dominguez, M. (Manuela), Donovan, J.L. (Jenny L.), Dörk, T. (Thilo), Duell, E.J. (Eric), Dunning, A.M. (Alison M.), Dwek, M. (Miriam), Eccles, D. (Diana), Edlund, C.K. (Christopher), Edwards, D.R.V. (Digna R Velez), Ellberg, C. (Carolina), Evans, D.G. (D Gareth), Fasching, P.A. (Peter), Ferris, R.L. (Robert L.), Liloglou, T. (Triantafillos), Figueiredo, J.C. (Jane C.), Fletcher, O. (Olivia), Fortner, R.T. (Renée T), Fostira, F. (Florentia), Franceschi, S. (Silvia), Friedman, E. (Eitan), Gallinger, S. (Steve), Ganz, P.A. (Patricia), Garber, J. (Judy), García-Sáenz, J.A. (José A), Gayther, S.A. (Simon), Giles, G.G. (Graham G.), Godwin, A.K. (Andrew K.), Goldberg, M.S. (Mark), Goldgar, D.E. (David E.), Goode, E.L. (Ellen), Goodman, M.T. (Marc), Goodman, G. (Gary), Grankvist, K. (Kjell), Greene, M.H. (Mark H.), Grönberg, H. (Henrik), Gronwald, J. (Jacek), Guénel, P. (Pascal), Håkansson, N. (Niclas), Hall, P. (Per), Hamann, U. (Ute), Hamdy, F. (Freddie), Hamilton, R.J. (Robert J.), Hampe, J. (Jochen), Haugen, A. (Aage), Heitz, F. (Florian), Herrero, R. (Rolando), Hillemanns, P. (Peter), Hoffmeister, M. (Michael), Høgdall, E. (Estrid), Hong, Y.-C. (Yun-Chul), Hopper, J.L. (John), Houlston, R. (Richard), Hulick, P.J. (Peter J.), Hunter, D.J. (David), Huntsman, D.G. (David G.), Idos, G. (Gregory), Imyanitov, E.N. (Evgeny), Ingles, S.A. (Sue), Isaacs, C. (Claudine), Jakubowska, A. (Anna), James, M. (Margaret), Jenkins, M.A. (Mark A.), Johansson, M. (Mattias), Johansson, M. (Mikael), John, E.M. (Esther), Joshi, A.D. (Amit D.), Kaneva, R. (Radka), Karlan, B.Y. (Beth), Kelemen, L.E. (Linda E.), Kühl, T. (Tabea), Khaw, K.-T. (Kay-Tee), Khusnutdinova, E.K. (Elza), Kibel, A. (Adam), Kiemeney, L.A. (Lambertus A.), Kim, J. (Jongoh), Kjaer, M. (Michael), Knight, J.A. (Julia), Kogevinas, M. (Manolis), Kote-Jarai, Z., Koutros, S. (Stella), Kristensen, V. (Vessela), Kupryjanczyk, J. (Jolanta), Lacko, M. (Martin), Lam, S. (Stephan), Lambrechts, D. (Diether), Landi, M.T. (Maria Teresa), Lazarus, P. (Philip), Le, N.D. (Nhu D.), Lee, E. (Eunjung), Lejbkowicz, F. (Flavio), Lenz, H.-J. (Heinz-Josef), Leslie, G. (Goska), Lessel, D. (Davor), Lester, J. (Jenny), Levine, D.A. (Douglas), Li, L. (Li), Li, C.I. (Christopher I.), Lindblom, A. (Annika), Lindor, N.M. (Noralane), Liu, G. (Geoffrey), Loupakis, F. (Fotios), Lubinski, J. (Jan), Maehle, L., Maier, C. (Christiane), Mannermaa, A. (Arto), Le Marchand, L. (Loic), Margolin, S. (Sara), May, T. (Taymaa), McGuffog, L. (Lesley), Meindl, A. (Alfons), Middha, P. (Pooja), Miller, A. (Austin), Milne, R.L. (Roger), MacInnis, R.J. (Robert J.), Modugno, F. (Francesmary), Montagna, M. (Marco), Moreno, V. (Víctor), Moysich, K.B. (Kirsten), Mucci, L. (Lorelei), Muir, K. (Kenneth), Mulligan, A.-M. (Anna-Marie), Nathanson, K.L. (Katherine), Neal, D. (David), Ness, A.R. (Andrew R.), Neuhausen, S.L. (Susan L.), Nevanlinna, H. (Heli), Newcomb, P. (Polly), Newcomb, L.F. (Lisa F.), Nielsen, F. (Finn), Nikitina-Zake, L. (Liene), Nordestgaard, B.G. (Børge), Nussbaum, R. (Robert), Offit, K. (Kenneth), Olah, E. (Edith), Olama, A.A.A. (Ali Amin Al), Olopade, O.I. (Olofunmilayo), Olshan, A.F. (Andrew F.), Olsson, H. (Håkan), Osorio, A. (Ana), Pandha, H. (Hardev), Park, J.Y. (Jong Y.), Pashayan, N. (Nora), Parsons, M. (Marilyn), Pejovic, T. (Tanja), Penney, K.L. (Kathryn L.), Peters, W.H.M. (Wilbert), Phelan, C. (Catherine), Phipps, A.I. (Amanda I.), Plaseska-Karanfilska, D. (Dijana), Pring, M. (Miranda), Prokofyeva, D. (Darya), Radice, P. (Paolo), Stefansson, K. (Kari), Ramus, S.J. (Susan), Raskin, L. (Leon), Rennert, G. (Gad), Rennert, H.S. (Hedy S.), Rensburg, E.J. (Elizabeth) van, Riggan, M.J. (Marjorie J.), Risch, H.A. (Harvey A.), Risch, A. (Angela), Roobol, M.J. (Monique J.), Rosenstein, B.S. (Barry S.), Rossing, M.A. (Mary Anne), De Ruyck, K. (Kim), Saloustros, E. (Emmanouil), Sandler, D.P. (Dale P.), Sawyer, E.J. (Elinor J.), Schabath, M.B. (Matthew), Schleutker, J. (Johanna), Schmidt, M.K. (Marjanka), Setiawan, V.W. (V Wendy), Shen, H. (Hongbing), Siegel, E.M. (Erin M.), Sieh, W. (Weiva), Singer, C.F. (Christian), Slattery, M.L. (Martha L.), Sorensen, K.D. (Karina Dalsgaard), Southey, M.C. (Melissa), Spurdle, A.B. (Amanda), Stanford, J.L. (Janet L.), Stevens, V.L. (Victoria L.), Stintzing, S. (Sebastian), Stone, J. (Jennifer), Sundfeldt, K. (Karin), Sutphen, R. (Rebecca), Swerdlow, A.J. (Anthony ), Tajara, E.H. (Eloiza H.), Tangen, C.M. (Catherine M.), Tardón, A. (Adonina), Taylor, J.A. (Jack A.), Teare, M.D. (M Dawn), Teixeira, P.J., Terry, M.B. (Mary Beth), Terry, K.L. (Kathryn L.), Thibodeau, S.N. (Stephen), Thomassen, M. (Mads), Bjørge, L. (Line), Tischkowitz, M. (Marc), Toland, A.E. (Amanda), Torres, D. (Diana), Townsend, P.A. (Paul A.), Travis, S.P.L. (Simon), Tung, N. (Nadine), Tworoger, S. (Shelley), Ulrich, C. (Cornelia), Usmani, N. (Nawaid), Vachon, C. (Celine), Van Nieuwenhuysen, E. (Els), Vega, A. (Ana), Aguado-Barrera, M.E. (Miguel Elías), Wang, Q. (Qin), Webb, P. (Penny), Weinberg, C.R. (Clarice R.), Weinstein, S. (Stephanie), Weissler, M.C. (Mark C.), Weitzel, J.N. (Jeffrey), West, C.M.L. (Catharine M L), White, E. (Emily), Whittemore, A.S. (Alice), Wichmann, H.-E. (H-Erich), Wiklund, F. (Fredrik), Winqvist, R. (Robert), Wolk, K. (Kerstin), Woll, P.J. (Penella J), Woods, M.O. (Michael), Wu, A.H. (Anna H.), Wu, X. (Xifeng), Yannoukakos, D. (Drakoulis), Zheng, W. (Wei), Zienolddiny, S. (Shanbeh), Ziogas, A. (Argyrios), Zorn, K.K. (Kristin K.), Lane, J.M. (Jacqueline M.), Saxena, R. (Richa), Thomas, D.C. (Duncan), Hung, R.J. (Rayjean J.), Diergaarde, B. (Brenda), McKay, J. (James), Peters, U. (Ulrike), Hsu, L. (Li), García-Closas, M. (Montserrat), Eeles, R.A. (Rosalind A.), Chenevix-Trench, G. (Georgia), Brennan, P.J. (Paul J.), Haiman, C.A. (Christopher), Simard, J. (Jacques), Easton, D.F. (Douglas), Gruber, S.B. (Stephen), Pharoah, P.D.P. (Paul), Price, A.L. (Alkes L.), Pasaniuc, B. (Bogdan), Amos, C.I. (Christopher I.), Kraft, P. (Peter), and Lindström, S. (Sara)
- Abstract
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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- 2019
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22. Large-scale transcriptome-wide association study identifies new prostate cancer risk regions
- Author
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Mancuso, N. (Nicholas), Gayther, S.A. (Simon), Gusev, A. (Alexander), Zheng, W. (Wei), Penney, K.L. (Kathryn L.), Kote-Jarai, Z., Eeles, R. (Rosalind), Freedman, M. (Matthew), Haiman, C.A. (Christopher), Pasaniuc, B. (Bogdan), Henderson, B.E. (Brian), Benlloch, S. (Sara), Schumacher, F. (Fredrick), Olama, A.A.A. (Ali Amin Al), Muir, K. (Kenneth), Berndt, S.I. (Sonja), Conti, G. (Giario), Wiklund, F. (Fredrik), Chanock, S.J. (Stephen), Stevens, V.L. (Victoria L.), Tangen, C.M. (Catherine M.), Batra, J. (Jyotsna), Clements, J. (Judith), Grönberg, H. (Henrik), Pashayan, N. (Nora), Schleutker, J. (Johanna), Albanes, D. (Demetrius), Weinstein, S. (Stephanie), Wolk, K. (Kerstin), West, C. (Catharine), Mucci, L. (Lorelei), Cancel-Tassin, G. (Géraldine), Koutros, S. (Stella), Sorensen, K.D. (Karina Dalsgaard), Maehle, L., Neal, D. (David), Hamdy, F. (Freddie), Donovan, J. (Jenny), Travis, S.P.L. (Simon), Hamilton, R.J. (Robert J.), Ingles, S.A. (Sue), Rosenstein, B.S. (Barry S.), Lu, Y.-J. (Yong-Jie), Giles, G.G. (Graham G.), Kibel, A. (Adam), Vega, A. (Ana), Kogevinas, M. (Manolis), Park, J.Y. (Jong Y.), Stanford, J.L. (Janet L.), Cybulski, C. (Cezary), Nordestgaard, B.G. (Børge), Brenner, H. (Hermann), Maier, C. (Christiane), Kim, J. (Jongoh), John, E.M. (Esther), Teixeira, P.J., Neuhausen, S.L. (Susan), De Ruyck, K. (Kim), Razack, A. (Azad), Newcomb, L.F. (Lisa F.), Lessel, D. (Davor), Kaneva, R. (Radka), Usmani, N. (Nawaid), Claessens, F. (Frank), Townsend, P.A. (Paul A.), Dominguez, M.G. (Manuela Gago), Roobol-Bouts, M.J. (Monique), Menegaux, F. (Florence), Khaw, K.-T. (Kay-Tee), Cannon-Albright, L.A. (Lisa), Pandha, H. (Hardev), Thibodeau, S.N. (Stephen N.), Hunter, D.J. (David J.), Kraft, P. (Peter), Mancuso, N. (Nicholas), Gayther, S.A. (Simon), Gusev, A. (Alexander), Zheng, W. (Wei), Penney, K.L. (Kathryn L.), Kote-Jarai, Z., Eeles, R. (Rosalind), Freedman, M. (Matthew), Haiman, C.A. (Christopher), Pasaniuc, B. (Bogdan), Henderson, B.E. (Brian), Benlloch, S. (Sara), Schumacher, F. (Fredrick), Olama, A.A.A. (Ali Amin Al), Muir, K. (Kenneth), Berndt, S.I. (Sonja), Conti, G. (Giario), Wiklund, F. (Fredrik), Chanock, S.J. (Stephen), Stevens, V.L. (Victoria L.), Tangen, C.M. (Catherine M.), Batra, J. (Jyotsna), Clements, J. (Judith), Grönberg, H. (Henrik), Pashayan, N. (Nora), Schleutker, J. (Johanna), Albanes, D. (Demetrius), Weinstein, S. (Stephanie), Wolk, K. (Kerstin), West, C. (Catharine), Mucci, L. (Lorelei), Cancel-Tassin, G. (Géraldine), Koutros, S. (Stella), Sorensen, K.D. (Karina Dalsgaard), Maehle, L., Neal, D. (David), Hamdy, F. (Freddie), Donovan, J. (Jenny), Travis, S.P.L. (Simon), Hamilton, R.J. (Robert J.), Ingles, S.A. (Sue), Rosenstein, B.S. (Barry S.), Lu, Y.-J. (Yong-Jie), Giles, G.G. (Graham G.), Kibel, A. (Adam), Vega, A. (Ana), Kogevinas, M. (Manolis), Park, J.Y. (Jong Y.), Stanford, J.L. (Janet L.), Cybulski, C. (Cezary), Nordestgaard, B.G. (Børge), Brenner, H. (Hermann), Maier, C. (Christiane), Kim, J. (Jongoh), John, E.M. (Esther), Teixeira, P.J., Neuhausen, S.L. (Susan), De Ruyck, K. (Kim), Razack, A. (Azad), Newcomb, L.F. (Lisa F.), Lessel, D. (Davor), Kaneva, R. (Radka), Usmani, N. (Nawaid), Claessens, F. (Frank), Townsend, P.A. (Paul A.), Dominguez, M.G. (Manuela Gago), Roobol-Bouts, M.J. (Monique), Menegaux, F. (Florence), Khaw, K.-T. (Kay-Tee), Cannon-Albright, L.A. (Lisa), Pandha, H. (Hardev), Thibodeau, S.N. (Stephen N.), Hunter, D.J. (David J.), and Kraft, P. (Peter)
- Abstract
Although genome-wide association studies (GWAS) for prostate cancer (PrCa) have identified more than 100 risk regions, most of the risk genes at these regions remain largely unknown. Here we integrate the largest PrCa GWAS (N = 142,392) with gene expression measured in 45 tissues (N = 4458), including normal and tumor prostate, to perform a multi-tissue transcriptome-wide association study (TWAS) for PrCa. We identify 217 genes at 84 independent 1 Mb regions associated with PrCa risk, 9 of which are regions
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- 2018
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23. Germline variation at 8q24 and prostate cancer risk in men of European ancestry
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Matejcic, M. (Marco), Saunders, E.J. (Edward J.), Dadaev, T. (Tokhir), Brook, R.H., Wang, K. (Kan), Sheng, X. (Xin), Olama, A.A.A. (Ali Amin Al), Schumacher, F. (Fredrick), Ingles, S.A. (Sue), Govindasami, K. (Koveela), Benlloch, S. (Sara), Berndt, S.I. (Sonja), Albanes, D. (Demetrius), Koutros, S. (Stella), Muir, K. (Kenneth), Stevens, V.L. (Victoria L.), Gapstur, S.M. (Susan M.), Tangen, C.M. (Catherine M.), Batra, J. (Jyotsna), Clements, J. (Judith), Grönberg, H. (Henrik), Pashayan, N. (Nora), Schleutker, J. (Johanna), Wolk, K. (Kerstin), West, C. (Catharine), Mucci, L. (Lorelei), Kraft, P. (Peter), Cancel-Tassin, G. (Géraldine), Sorensen, K.D. (Karina D.), Maehle, L., Grindedal, E.M. (Eli M.), Strom, S., Neal, D. (David), Hamdy, F. (Freddie), Donovan, J. (Jenny), Travis, S.P.L. (Simon), Hamilton, R.J. (Robert J.), Rosenstein, B.S. (Barry S.), Lu, Y.-J. (Yong-Jie), Giles, G.G. (Graham G.), Kibel, A. (Adam), Vega, A. (Ana), Bensen, J.T. (Jeanette T.), Kogevinas, M. (Manolis), Penney, K.L. (Kathryn L.), Park, J.Y. (Jong Y.), Stanford, J.L. (Janet L.), Cybulski, C. (Cezary), Nordestgaard, B.G. (Børge), Brenner, H. (Hermann), Maier, C. (Christiane), Kim, J. (Jongoh), Teixeira, P.J., Neuhausen, S.L. (Susan), De Ruyck, K. (Kim), Razack, A. (Azad), Newcomb, L.F. (Lisa F.), Lessel, D. (Davor), Kaneva, R. (Radka), Usmani, N. (Nawaid), Claessens, F. (Frank), Townsend, P.A. (Paul A.), Dominguez, M.G. (Manuela G.), Roobol-Bouts, M.J. (Monique), Menegaux, F. (Florence), Khaw, K.-T. (Kay-Tee), Cannon-Albright, L.A. (Lisa), Pandha, H. (Hardev), Thibodeau, S.N. (Stephen N.), Schaid, D.J. (D.), Wiklund, F. (Fredrik), Chanock, S.J. (Stephen J.), Easton, D.F. (Douglas), Eeles, R.A. (Rosalind A.), Kote-Jarai, Z., Conti, G. (Giario), Haiman, C.A. (Christopher), Matejcic, M. (Marco), Saunders, E.J. (Edward J.), Dadaev, T. (Tokhir), Brook, R.H., Wang, K. (Kan), Sheng, X. (Xin), Olama, A.A.A. (Ali Amin Al), Schumacher, F. (Fredrick), Ingles, S.A. (Sue), Govindasami, K. (Koveela), Benlloch, S. (Sara), Berndt, S.I. (Sonja), Albanes, D. (Demetrius), Koutros, S. (Stella), Muir, K. (Kenneth), Stevens, V.L. (Victoria L.), Gapstur, S.M. (Susan M.), Tangen, C.M. (Catherine M.), Batra, J. (Jyotsna), Clements, J. (Judith), Grönberg, H. (Henrik), Pashayan, N. (Nora), Schleutker, J. (Johanna), Wolk, K. (Kerstin), West, C. (Catharine), Mucci, L. (Lorelei), Kraft, P. (Peter), Cancel-Tassin, G. (Géraldine), Sorensen, K.D. (Karina D.), Maehle, L., Grindedal, E.M. (Eli M.), Strom, S., Neal, D. (David), Hamdy, F. (Freddie), Donovan, J. (Jenny), Travis, S.P.L. (Simon), Hamilton, R.J. (Robert J.), Rosenstein, B.S. (Barry S.), Lu, Y.-J. (Yong-Jie), Giles, G.G. (Graham G.), Kibel, A. (Adam), Vega, A. (Ana), Bensen, J.T. (Jeanette T.), Kogevinas, M. (Manolis), Penney, K.L. (Kathryn L.), Park, J.Y. (Jong Y.), Stanford, J.L. (Janet L.), Cybulski, C. (Cezary), Nordestgaard, B.G. (Børge), Brenner, H. (Hermann), Maier, C. (Christiane), Kim, J. (Jongoh), Teixeira, P.J., Neuhausen, S.L. (Susan), De Ruyck, K. (Kim), Razack, A. (Azad), Newcomb, L.F. (Lisa F.), Lessel, D. (Davor), Kaneva, R. (Radka), Usmani, N. (Nawaid), Claessens, F. (Frank), Townsend, P.A. (Paul A.), Dominguez, M.G. (Manuela G.), Roobol-Bouts, M.J. (Monique), Menegaux, F. (Florence), Khaw, K.-T. (Kay-Tee), Cannon-Albright, L.A. (Lisa), Pandha, H. (Hardev), Thibodeau, S.N. (Stephen N.), Schaid, D.J. (D.), Wiklund, F. (Fredrik), Chanock, S.J. (Stephen J.), Easton, D.F. (Douglas), Eeles, R.A. (Rosalind A.), Kote-Jarai, Z., Conti, G. (Giario), and Haiman, C.A. (Christopher)
- Abstract
Chromosome 8q24 is a susceptibility locus for multiple cancers, including prostate cancer. Here we combine genetic data across the 8q24 susceptibility region from 71,535 prostate cancer cases and 52,935 controls of European ancestry to define the overall contribution of germline variation at 8q24 to prostate cancer risk. We identify 12 independent risk signals for prostate cancer (p < 4.28 × 10-15), including three risk variants that have yet to be reported. From a polygenic risk score (PRS) model, derived to assess the cumulative effect of risk variants at 8q24, men in the top 1% of the PRS have a 4-fold (95%CI = 3.62-4.40) greater risk compared to the population average. These 12 variants account for ~25% of what can be currently explained of the familial risk of prostate cancer by known genetic risk factors. These findings highlight the overwhelming contribution of germline variation at 8q24 on prostate cancer risk which has implications for population risk stratification.
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- 2018
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24. Developing a Standard Set of Patient-Centred Outcomes for inflammatory Bowel Disease-an international, cross-disciplinary consensus
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Kim, A.H. (Andrew H.), Roberts, C. (Charlotte), Feagan, B.G. (Brian), Banerjee, R. (Rupa), Bemelman, W.A. (Willem), Bodger, K. (Keith), Derieppe, M. (Marc), Dignass, A. (Axel), Driscoll, R. (Richard), Fitzpatrick, R. (Ray), Gaarentstroom-Lunt, J. (Janette), Higgins, P.D. (Peter D.), Kotze, P.G. (Paulo Gustavo), Meissner, J. (Jillian), O'Connor, M. (Marian), Ran, Z.-H. (Zhi-Hua), Siegel, C.A. (Corey), Terry, H. (Helen), van Deen, W.K. (Welmoed K.), Woude, C.J. (Janneke) van der, Weaver, A. (Alandra), Yang, S.-K. (Suk-Kyun), Sands, B.E. (Bruce E.), Vermeire, S. (Séverine), Travis, S.P.L. (Simon), Kim, A.H. (Andrew H.), Roberts, C. (Charlotte), Feagan, B.G. (Brian), Banerjee, R. (Rupa), Bemelman, W.A. (Willem), Bodger, K. (Keith), Derieppe, M. (Marc), Dignass, A. (Axel), Driscoll, R. (Richard), Fitzpatrick, R. (Ray), Gaarentstroom-Lunt, J. (Janette), Higgins, P.D. (Peter D.), Kotze, P.G. (Paulo Gustavo), Meissner, J. (Jillian), O'Connor, M. (Marian), Ran, Z.-H. (Zhi-Hua), Siegel, C.A. (Corey), Terry, H. (Helen), van Deen, W.K. (Welmoed K.), Woude, C.J. (Janneke) van der, Weaver, A. (Alandra), Yang, S.-K. (Suk-Kyun), Sands, B.E. (Bruce E.), Vermeire, S. (Séverine), and Travis, S.P.L. (Simon)
- Abstract
Background and Aims: Success in delivering value-based healthcare involves measuring outcomes that matter most to patients. Our aim was to develop a minimum Standard Set of patient-centred outcome measures for inflammatory bowel disease [IBD], for use in different healthcare settings. Methods: An international working group [n = 25] representing patients, patient associations, gastroenterologists, surgeons, specialist nurses, IBD registries and patient-reported outcome measure [PROM] methodologists participated in a series of teleconferences incorporating a modified Delphi process. Systematic review of existing literature, registry data, patient focus groups and open review periods were used to reach consensus on a minimum set of standard outcome measures and risk adjustment variables. Similar methodology has been used in 21 other disease areas [www.ichom.org]. Results: A minimum Standard Set of outcomes was developed for patients [aged =16] with IBD. Outcome domains included survival and disease control [survival, disease activity/remission, colorectal cancer, anaemi
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- 2018
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25. Identification of multiple risk loci and regulatory mechanisms influencing susceptibility to multiple myeloma
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Went, M. (Molly), Sud, A. (Amit), Försti, A. (Asta), Halvarsson, B.-M. (Britt-Marie), Weinhold, N. (Niels), Kimber, S. (Scott), Duin, M. (Mark) van, Thorleifsson, G. (Gudmar), Holroyd, A. (Amy), Johnson, D.C. (David C.), Li, N. (Ni), Orlando, G. (Giulia), Law, P.J. (Philip J.), Ali, M. (Mina), Chen, B. (Bowang), Mitchell, J.S. (Jonathan S.), Gudbjartsson, D.F. (Daniel), Kuiper, R. (Ruud), Stephens, O.W. (Owen W.), Bertsch, U. (Uta), Broderick, P. (Peter), Campo, C. (Chiara), Bandapalli, O.R. (Obul R), Einsele, H. (Hermann), Gregory, W.A. (Walter A.), Gullberg, U. (Urban), Hillengass, J. (Jens), Hoffmann, P. (Per), Jackson, G.H. (Graham H.), JöCkel, K.-H. (Karl-Heinz), Johnsson, E. (Ellinor), Kristinsson, S.Y. (Sigurður Y.), Mellqvist, U.H. (U. H.), Nahi, H. (Hareth), Easton, D.F. (Douglas), Pharoah, P. (Paul), Dunning, A. (Alison), Peto, J. (Julian), Canzian, F. (Federico), Swerdlow, A.J. (Anthony ), Eeles, R.A. (Rosalind A.), Kote-Jarai, Z., Muir, K. (Kenneth), Pashayan, N. (Nora), Nickel, J. (Jolanta), Nöthen, M.M. (Markus), Rafnar, T. (Thorunn), Ross, F.M. (Fiona M.), da Silva Filho, M.I. (Miguel Inacio), Thomsen, H. (Hauke), Turesson, I. (I.), Vangsted, A. (Annette), Andersen, N.F. (Niels Frost), Waage, A. (Anders), Walker, B. (BrianA.), Wihlborg, A.-K. (Anna-Karin), Broyl, A. (Annemiek), Davies, F.E. (F.), Thorsteinsdottir, U. (Unnur), Langer, C. (Christian), Hansson, M. (Markus), Goldschmidt, H. (Hartmut), Kaiser, M.F. (Martin F.), Sonneveld, P. (Pieter), Zwart, J-A. (John-Anker), Morgan, G. (Gareth), Hemminki, K. (Kari), Nilsson, B. (Björn), Houlston, R.S. (Richard S.), Henderson, B.E. (Brian), Haiman, C.A. (Christopher), Benlloch, S. (Sara), Schumacher, F.R. (Fredrick R), Olama, A.A.A. (Ali Amin Al), Berndt, S.I. (Sonja), Conti, G. (Giario), Wiklund, F. (Fredrik), Chanock, S.J. (Stephen), Stevens, V.L. (Victoria L.), Tangen, C.M. (Catherine M.), Batra, J. (Jyotsna), Clements, J. (Judith), Grönberg, H. (Henrik), Schleutker, J. (Johanna), Albanes, D. (Demetrius), Weinstein, S. (Stephanie), Wolk, K. (Kerstin), West, C. (Catharine), Mucci, L. (Lorelei), Cancel-Tassin, G. (Géraldine), Koutros, S. (Stella), Sorensen, K.D. (Karina Dalsgaard), Grindedal, E.M. (Eli Marie), Neal, D.E. (David E.), Hamdy, F. (Freddie), Donovan, J.L. (Jenny L.), Travis, S.P.L. (Simon), Hamilton, R.J. (Robert J.), Ingles, S.A. (Sue), Rosenstein, B.S. (Barry S.), Lu, Y.-J. (Yong-Jie), Giles, G.G. (Graham G.), Kibel, A. (Adam), Vega, A. (Ana), Kogevinas, M. (Manolis), Penney, K.L. (Kathryn L.), Park, J.Y. (Jong Y.), Stanford, J.L. (Janet L.), Cybulski, C. (Cezary), Nordestgaard, B.G. (Børge), Brenner, H. (Hermann), Maier, C. (Christiane), Kim, J. (Jeri), John, E.M. (Esther), Teixeira, P.J., Neuhausen, S.L. (Susan), De Ruyck, K. (Kim), Razack, A. (Azad), Newcomb, L.F. (Lisa F.), Lessel, D. (Davor), Kaneva, R. (Radka), Usmani, N. (Nawaid), Claessens, F., Townsend, P.A. (Paul A.), Dominguez, M.G. (Manuela Gago), Roobol-Bouts, M.J. (Monique), Menegaux, F. (Florence), Khaw, K.-T. (Kay-Tee), Cannon-Albright, L.A. (Lisa), Pandha, H. (Hardev), Thibodeau, S.N. (Stephen N.), Went, M. (Molly), Sud, A. (Amit), Försti, A. (Asta), Halvarsson, B.-M. (Britt-Marie), Weinhold, N. (Niels), Kimber, S. (Scott), Duin, M. (Mark) van, Thorleifsson, G. (Gudmar), Holroyd, A. (Amy), Johnson, D.C. (David C.), Li, N. (Ni), Orlando, G. (Giulia), Law, P.J. (Philip J.), Ali, M. (Mina), Chen, B. (Bowang), Mitchell, J.S. (Jonathan S.), Gudbjartsson, D.F. (Daniel), Kuiper, R. (Ruud), Stephens, O.W. (Owen W.), Bertsch, U. (Uta), Broderick, P. (Peter), Campo, C. (Chiara), Bandapalli, O.R. (Obul R), Einsele, H. (Hermann), Gregory, W.A. (Walter A.), Gullberg, U. (Urban), Hillengass, J. (Jens), Hoffmann, P. (Per), Jackson, G.H. (Graham H.), JöCkel, K.-H. (Karl-Heinz), Johnsson, E. (Ellinor), Kristinsson, S.Y. (Sigurður Y.), Mellqvist, U.H. (U. H.), Nahi, H. (Hareth), Easton, D.F. (Douglas), Pharoah, P. (Paul), Dunning, A. (Alison), Peto, J. (Julian), Canzian, F. (Federico), Swerdlow, A.J. (Anthony ), Eeles, R.A. (Rosalind A.), Kote-Jarai, Z., Muir, K. (Kenneth), Pashayan, N. (Nora), Nickel, J. (Jolanta), Nöthen, M.M. (Markus), Rafnar, T. (Thorunn), Ross, F.M. (Fiona M.), da Silva Filho, M.I. (Miguel Inacio), Thomsen, H. (Hauke), Turesson, I. (I.), Vangsted, A. (Annette), Andersen, N.F. (Niels Frost), Waage, A. (Anders), Walker, B. (BrianA.), Wihlborg, A.-K. (Anna-Karin), Broyl, A. (Annemiek), Davies, F.E. (F.), Thorsteinsdottir, U. (Unnur), Langer, C. (Christian), Hansson, M. (Markus), Goldschmidt, H. (Hartmut), Kaiser, M.F. (Martin F.), Sonneveld, P. (Pieter), Zwart, J-A. (John-Anker), Morgan, G. (Gareth), Hemminki, K. (Kari), Nilsson, B. (Björn), Houlston, R.S. (Richard S.), Henderson, B.E. (Brian), Haiman, C.A. (Christopher), Benlloch, S. (Sara), Schumacher, F.R. (Fredrick R), Olama, A.A.A. (Ali Amin Al), Berndt, S.I. (Sonja), Conti, G. (Giario), Wiklund, F. (Fredrik), Chanock, S.J. (Stephen), Stevens, V.L. (Victoria L.), Tangen, C.M. (Catherine M.), Batra, J. (Jyotsna), Clements, J. (Judith), Grönberg, H. (Henrik), Schleutker, J. (Johanna), Albanes, D. (Demetrius), Weinstein, S. (Stephanie), Wolk, K. (Kerstin), West, C. (Catharine), Mucci, L. (Lorelei), Cancel-Tassin, G. (Géraldine), Koutros, S. (Stella), Sorensen, K.D. (Karina Dalsgaard), Grindedal, E.M. (Eli Marie), Neal, D.E. (David E.), Hamdy, F. (Freddie), Donovan, J.L. (Jenny L.), Travis, S.P.L. (Simon), Hamilton, R.J. (Robert J.), Ingles, S.A. (Sue), Rosenstein, B.S. (Barry S.), Lu, Y.-J. (Yong-Jie), Giles, G.G. (Graham G.), Kibel, A. (Adam), Vega, A. (Ana), Kogevinas, M. (Manolis), Penney, K.L. (Kathryn L.), Park, J.Y. (Jong Y.), Stanford, J.L. (Janet L.), Cybulski, C. (Cezary), Nordestgaard, B.G. (Børge), Brenner, H. (Hermann), Maier, C. (Christiane), Kim, J. (Jeri), John, E.M. (Esther), Teixeira, P.J., Neuhausen, S.L. (Susan), De Ruyck, K. (Kim), Razack, A. (Azad), Newcomb, L.F. (Lisa F.), Lessel, D. (Davor), Kaneva, R. (Radka), Usmani, N. (Nawaid), Claessens, F., Townsend, P.A. (Paul A.), Dominguez, M.G. (Manuela Gago), Roobol-Bouts, M.J. (Monique), Menegaux, F. (Florence), Khaw, K.-T. (Kay-Tee), Cannon-Albright, L.A. (Lisa), Pandha, H. (Hardev), and Thibodeau, S.N. (Stephen N.)
- Abstract
Genome-wide association studies (GWAS) have transformed our understanding of susceptibility to multiple myeloma (MM), but much of the heritability remains unexplained. We report a new GWAS, a meta-analysis with previous GWAS and a replication series, totalling 9974 MM cases and 247,556 controls of European ancestry. Collectively, these data provide evidence for six new MM risk loci, bringing the total number to 23. Integration of information from gene expression, epigenetic profiling and in situ Hi-C data for the 23 risk loci implicate disruption of developmental transcriptional regulators as a basis of MM susceptibility, compatible with altered B-cell differentiation as a key mechanism. Dysregulation of autophagy/apoptosis and cell cycle signalling feature as recurrently perturbed pathways. Our findings provide further insight i
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- 2018
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26. Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer
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Phelan, C. (Catherine), Kuchenbaecker, K.B. (Karoline), Tyrer, J.P. (Jonathan P.), Kar, S.P. (Siddhartha P.), Lawrenson, K. (Kate), Winham, S.J. (Stacey J.), Dennis, J. (Joe), Pirie, A. (Ailith), Riggan, M.J. (Marjorie J.), Chornokur, G. (Ganna), Earp, M.A. (Madalene A.), Lyra, P.C. (Paulo C.), Lee, J.M. (Janet M.), Coetzee, S. (Simon), Beesley, J. (Jonathan), McGuffog, L. (Lesley), Soucy, P. (Penny), Dicks, E. (Ed), Lee, A. (Andrew), Barrowdale, D. (Daniel), Lecarpentier, J. (Julie), Leslie, G. (Goska), Aalfs, C.M. (Cora), Aben, K.K.H. (Katja), Adams, M. (Marcia), Adlard, J.W. (Julian), Andrulis, I.L. (Irene), Anton-Culver, H. (Hoda), Antonenkova, N. (Natalia), Aravantinos, G. (Gerasimos), Arnold, N. (Norbert), Arun, B.K. (Banu), Arver, B. (Brita), Azzollini, J., Balmana, J. (Judith), Banerjee, S. (Susana), Barjhoux, L. (Laure), Barkardottir, R.B. (Rosa B.), Bean, Y. (Yukie), Beckmann, M.W. (Matthias), Beeghly-Fadiel, A. (Alicia), Benítez, J. (Javier), Bermisheva, M. (Marina), Bernardini, M.Q. (Marcus Q.), Birrer, M.J. (Michael J.), Bjorge, L. (Line), Black, A., Blankstein, K. (Kenneth), Blok, M.J. (Marinus), Bodelon, C. (Clara), Bogdanova, N. (Natalia), Bojesen, A. (Anders), Bonanni, B. (Bernardo), Borg, Å. (Åke), Bradbury, A.R. (Angela R.), Brenton, J.D. (James D.), Brewer, C. (Carole), Brinton, L.A. (Louise), Broberg, P. (Per), Brooks-Wilson, A. (Angela), Bruinsma, F. (Fiona), Brunet, J. (Joan), Buecher, B. (Bruno), Butzow, R. (Ralf), Buys, S.S. (Saundra), Caldes, T. (Trinidad), Caligo, M.A. (Maria A.), Campbell, I. (Ian), Cannioto, R. (Rikki), Carney, M.E. (Michael), Cescon, T. (Terence), Chan, S. (Salina), Chang-Claude, J. (Jenny), Chanock, S.J. (Stephen), Chen, X.Q. (Xiao Qing), Chiew, Y.-E. (Yoke-Eng), Chiquette, J. (Jocelyne), Chung, W. (Wendy), Claes, K. (Kathleen), Conner, T. (Thomas), Cook, L.S. (Linda S.), Cook, J. (Jackie), Cramer, D.W. (Daniel), Cunningham, J.M. (Julie), D'Aloisio, A.A. (Aimee A.), Daly, M.B. (Mary), Damiola, F. (Francesca), Damirovna, S.D. (Sakaeva Dina), Dansonka-Mieszkowska, A. (Agnieszka), Dao, F. (Fanny), Davidson, R. (Rosemarie), DeFazio, A. (Anna), Delnatte, C.D. (Capucine), Doheny, K.F. (Kimberly), Díez, O. (Orland), Ding, Y.C. (Yuan Chun), Doherty, J.A. (Jennifer), Domchek, S.M. (Susan), Dorfling, C.M. (Cecilia), Dörk, T. (Thilo), Dossus, L. (Laure), Duran, M. (Mercedes), Dürst, M. (Matthias), Dworniczak, B. (Bernd), Eccles, D. (Diana), Edwards, T. (Todd), Eeles, R. (Rosalind), Eilber, U. (Ursula), Ejlertsen, B. (Bent), Ekici, A.B. (Arif), Ellis, S. (Steve), Elvira, M. (Mingajeva), Eng, K.H. (Kevin H.), Engel, C. (Christoph), Evans, D.G. (Gareth), Fasching, P.A. (Peter), Ferguson, S. (Sarah), Ferrer, S.F., Flanagan, J.M. (James), Fogarty, Z.C. (Zachary C.), Fortner, R.T. (Renée T.), Fostira, F. (Florentia), Foulkes, W.D. (William D.), Fountzilas, G. (George), Fridley, B.L. (Brooke), Friebel, M.O.W. (Mark ), Friedman, E. (Eitan), Frost, D. (Debra), Ganz, P.A. (Patricia), Garber, J. (Judy), García, M.J. (María J.), Garcia-Barberan, V. (Vanesa), Gehrig, P.A. (Paola A.), Gentry-Maharaj, A. (Aleksandra), Gerdes, A-M. (Anne-Marie), Giles, G.G. (Graham G.), Glasspool, R. (Rosalind), Glendon, G. (Gord), Godwin, A.K. (Andrew K.), Radice, P. (Paolo), Goranova, T. (Teodora), Gore, M. (Martin), Greene, M.H. (Mark H.), Gronwald, J. (Jacek), Gruber, S.B. (Stephen), Hahnen, E. (Eric), Haiman, C.A. (Christopher), Håkansson, N. (Niclas), Hamann, U. (Ute), Hansen, T.V.O. (Thomas V.O.), Harrington, P.A. (Patricia A.), Harris, H.R. (Holly), Hauke, J. (Jan), Hein, A. (Alexander), Henderson, A. (Alex), Hildebrandt, M.A.T. (Michelle A.T.), Hillemanns, P. (Peter), Hodgson, S. (Shirley), Høgdall, C.K. (Claus), Høgdall, E. (Estrid), Hogervorst, F.B.L. (Frans B. L.), Holland, H. (Helene), Hooning, M.J. (Maartje J.), Hosking, K. (Karen), Huang, R.-Y. (Ruea-Yea), Hulick, P.J. (Peter), Hung, J. (Jillian), Hunter, D.J. (David J.), Huntsman, D.G. (David G.), Huzarski, T. (Tomasz), Imyanitov, E.N. (Evgeny), Isaacs, C. (Claudine), Iversen, E. (Erik), Izatt, L. (Louise), Izquierdo, A. (A.), Jakubowska, A. (Anna), James, P. (Paul), Janavicius, R. (Ramunas), Jernetz, M. (Mats), Jensen, A. (Allan), Jensen, U.B., John, E.M. (Esther), Johnatty, S.E. (Sharon), Jones, M.E. (Michael E.), Kannisto, P. (Päivi), Karlan, B.Y. (Beth), Karnezis, A. (Anthony), Kast, K. (Karin), Kennedy, C.J. (Catherine J.), Khusnutdinova, E.K. (Elza), Kiemeney, L.A.L.M. (Bart), Kiiski, J.I. (Johanna I.), Kim, S.-W. (Sung-Won), Kjaer, M. (Michael), Köbel, M. (Martin), Kopperud, R.K. (Reidun K.), Kruse, T.A. (Torben), Kupryjanczyk, J. (Jolanta), Kwong, A. (Ava), Laitman, Y. (Yael), Lambrechts, D. (Diether), Larrañaga, N. (Nerea), Larson, M.C. (Melissa), Lazaro, C. (Conxi), Le, N.D. (Nhu D.), Le Marchand, L. (Loic), Lee, J.W. (Jong Won), Lele, S.B. (Shashikant B.), Leminen, A. (Arto), Leroux, D. (Dominique), Lester, J. (Jenny), Lesueur, F. (Fabienne), Levine, D.A. (Douglas), Liang, D. (Dong), Liebrich, C. (Clemens), Lilyquist, J. (Jenna), Lipworth, L. (Loren), Lissowska, J. (Jolanta), Lu, K.H. (Karen), Lubinski, J. (Jan), Luccarini, C. (Craig), Lundvall, L. (Lene), Mai, P.L. (Phuong), Mendoza-Fandiño, G. (Gustavo), Manoukian, S. (Siranoush), Massuger, L.F. (Leon), May, T. (Taymaa), Mazoyer, S. (Sylvie), McAlpine, J.N. (Jessica N.), McGuire, V. (Valerie), McLaughlin, J. (John), McNeish, I. (Iain), Meijers-Heijboer, E.J. (Hanne), Meindl, A. (Alfons), Menon, U. (Usha), Mensenkamp, A.R. (Arjen R.), Merritt, M.A. (Melissa A.), Milne, R.L. (Roger), Mitchell, G. (Gillian), Modugno, F. (Francesmary), Moes-Sosnowska, J. (Joanna), Moffitt, M. (Melissa), Montagna, M. (Marco), Moysich, K.B. (Kirsten), Mulligan, A.M. (Anna Marie), Musinsky, J. (Jacob), Nathanson, K.L. (Katherine), Nedergaard, L. (Lotte), Ness, R.B. (Roberta), Neuhausen, S.L. (Susan), Nevanlinna, H. (Heli), Niederacher, D. (Dieter), Nussbaum, R. (Robert), Odunsi, K. (Kunle), Olah, E. (Edith), Olopade, O.I. (Olofunmilayo), Olsson, H. (Håkan), Olswold, C. (Curtis), O'Malley, D.M. (David M.), Ong, K.-R. (Kai-Ren), Onland-Moret, N.C. (Charlotte), Orr, N. (Nick), Orsulic, S. (Sandra), Osorio, A. (Ana), Palli, D. (Domenico), Papi, L. (Laura), Park-Simon, T.-W., Paul, J. (James), Pearce, C.L. (Celeste), Pedersen, I.S. (Inge Søkilde), Peeters, P.H.M., Peissel, B. (Bernard), Peixoto, A. (Ana), Pejovic, T. (Tanja), Pelttari, L.M. (Liisa M.), Permuth, J.B. (Jennifer B.), Peterlongo, P. (Paolo), Pezzani, L. (Lidia), Pfeiler, G. (Georg), Phillips, K.-A. (Kelly-Anne), Piedmonte, M. (Marion), Pike, M.C. (Malcolm), Piskorz, A.M. (Anna M.), Poblete, S.R. (Samantha R.), Pócza, T. (Tímea), Poole, E.M. (Elizabeth M.), Poppe, B. (Bruce), Porteous, M.E. (Mary), Prieur, F. (Fabienne), Prokofyeva, D. (Darya), Pugh, E. (Elizabeth), Pujana, M.A. (Miquel Angel), Pujol, P. (Pascal), Rantala, J. (Johanna), Rappaport-Fuerhauser, C. (Christine), Rennert, G. (Gad), Rhiem, K. (Kerstin), Rice, P. (Patricia), Richardson, A.L. (Andrea), Robson, M. (Mark), Rodriguez, G.C. (Gustavo), Rodríguez-Antona, C. (Cristina), Romm, J. (Jane), Rookus, M.A. (Matti), Rossing, M.A. (Mary Anne), Rothstein, J.H. (Joseph H.), Rudolph, A. (Anja), Runnebaum, I.B. (Ingo), Salvesen, H.B. (Helga), Sandler, D.P. (Dale P.), Schoemaker, M.J. (Minouk J.), Senter, L. (Leigha), Setiawan, V.W. (V. Wendy), Severi, G. (Gianluca), Sharma, P. (Priyanka), Shelford, T. (Tameka), Siddiqui, N. (Nadeem), Side, L. (Lucy), Sieh, W. (Weiva), Singer, C.F. (Christian), Sobol, H. (Hagay), Song, H. (Honglin), Southey, M.C. (Melissa), Spurdle, A.B. (Amanda), Stadler, Z. (Zsofia), Steinemann, D. (Doris), Stoppa-Lyonnet, D. (Dominique), Sucheston-Campbell, L.E. (Lara E.), Sukiennicki, G. (Grzegorz), Sutphen, R. (Rebecca), Sutter, C. (Christian), Swerdlow, A.J. (Anthony ), Szabo, C. (Csilla), Szafron, L. (Lukasz), Tan, Y.Y. (Yen Y.), Taylor, J.A. (Jack A.), Tea, M.-K., Teixeira, P.J., Teo, S.-H. (Soo-Hwang), Terry, K.L. (Kathryn L.), Thompson, P.J. (Pamela J.), Thomsen, L.C.V. (Liv Cecilie Vestrheim), Thull, D.L. (Darcy L.), Tihomirova, L. (Laima), Tinker, A.V. (Anna V.), Tischkowitz, M. (Marc), Tognazzo, S. (Silvia), Toland, A.E. (Amanda Ewart), Tone, A. (Alicia), Trabert, B. (Britton), Travis, S.P.L. (Simon), Trichopoulou, A. (Antonia), Tung, N. (Nadine), Tworoger, S. (Shelley), Van Altena, A.M. (Anne M.), Van Den Berg, D. (David), Van Der Hout, A.H. (Annemarie H.), Luijt, R.B. (Rob) van der, Van Heetvelde, M. (Mattias), Van Nieuwenhuysen, E. (Els), Rensburg, E.J. (Elizabeth) van, Vanderstichele, A. (Adriaan), Varon-Mateeva, R. (Raymonda), Vega, A. (Ana), Edwards, D.V. (Digna Velez), Vergote, I., Vierkant, R.A. (Robert), Vijai, J. (Joseph), Vratimos, A. (Athanassios), Walker, L.J. (Lisa), Walsh, C. (Christine), Wand, D. (Dorothea), Wang-Gohrke, S. (Shan), Wappenschmidt, B. (Barbara), Webb, P.M. (Penelope M.), Weinberg, C.R. (Clarice R.), Weitzel, J.N. (Jeffrey), Wentzensen, N. (N.), Whittemore, A.S. (Alice), Wijnen, J.T. (Juul), Wilkens, L.R. (Lynne), Wolk, K. (Kerstin), Woo, M. (Michelle), Wu, X. (Xifeng), Wu, A.H. (Anna), Yang, H.P. (Hannah), Yannoukakos, D. (Drakoulis), Ziogas, A. (Argyrios), Zorn, K.K. (Kristin K.), Narod, S.A. (Steven A.), Easton, D.F. (Douglas), Amos, W., Schildkraut, J.M. (Joellen), Ramus, S.J. (Susan), Ottini, L. (Laura), Goodman, M.T. (Marc), Park, S.K. (Sue K.), Kelemen, L.E. (Linda), Risch, H. (Harvey), Thomassen, M. (Mads), Offit, K. (Kenneth), Simard, J. (Jacques), Schmutzler, R.K. (Rita), Hazelett, D. (Dennis), Monteiro, A.N.A. (Alvaro N.), Couch, F.J. (Fergus), Berchuck, A. (Andrew), Chenevix-Trench, G. (Georgia), Goode, E.L. (Ellen), Sellers, T.F., Gayther, S.A. (Simon), Antoniou, A.C. (Antonis), Pharoah, P.D.P. (Paul), Phelan, C. (Catherine), Kuchenbaecker, K.B. (Karoline), Tyrer, J.P. (Jonathan P.), Kar, S.P. (Siddhartha P.), Lawrenson, K. (Kate), Winham, S.J. (Stacey J.), Dennis, J. (Joe), Pirie, A. (Ailith), Riggan, M.J. (Marjorie J.), Chornokur, G. (Ganna), Earp, M.A. (Madalene A.), Lyra, P.C. (Paulo C.), Lee, J.M. (Janet M.), Coetzee, S. (Simon), Beesley, J. (Jonathan), McGuffog, L. (Lesley), Soucy, P. (Penny), Dicks, E. (Ed), Lee, A. (Andrew), Barrowdale, D. (Daniel), Lecarpentier, J. (Julie), Leslie, G. (Goska), Aalfs, C.M. (Cora), Aben, K.K.H. (Katja), Adams, M. (Marcia), Adlard, J.W. (Julian), Andrulis, I.L. (Irene), Anton-Culver, H. (Hoda), Antonenkova, N. (Natalia), Aravantinos, G. (Gerasimos), Arnold, N. (Norbert), Arun, B.K. (Banu), Arver, B. (Brita), Azzollini, J., Balmana, J. (Judith), Banerjee, S. (Susana), Barjhoux, L. (Laure), Barkardottir, R.B. (Rosa B.), Bean, Y. (Yukie), Beckmann, M.W. (Matthias), Beeghly-Fadiel, A. (Alicia), Benítez, J. (Javier), Bermisheva, M. (Marina), Bernardini, M.Q. (Marcus Q.), Birrer, M.J. (Michael J.), Bjorge, L. (Line), Black, A., Blankstein, K. (Kenneth), Blok, M.J. (Marinus), Bodelon, C. (Clara), Bogdanova, N. (Natalia), Bojesen, A. (Anders), Bonanni, B. (Bernardo), Borg, Å. (Åke), Bradbury, A.R. (Angela R.), Brenton, J.D. (James D.), Brewer, C. (Carole), Brinton, L.A. (Louise), Broberg, P. (Per), Brooks-Wilson, A. (Angela), Bruinsma, F. (Fiona), Brunet, J. (Joan), Buecher, B. (Bruno), Butzow, R. (Ralf), Buys, S.S. (Saundra), Caldes, T. (Trinidad), Caligo, M.A. (Maria A.), Campbell, I. (Ian), Cannioto, R. (Rikki), Carney, M.E. (Michael), Cescon, T. (Terence), Chan, S. (Salina), Chang-Claude, J. (Jenny), Chanock, S.J. (Stephen), Chen, X.Q. (Xiao Qing), Chiew, Y.-E. (Yoke-Eng), Chiquette, J. (Jocelyne), Chung, W. (Wendy), Claes, K. (Kathleen), Conner, T. (Thomas), Cook, L.S. (Linda S.), Cook, J. (Jackie), Cramer, D.W. (Daniel), Cunningham, J.M. (Julie), D'Aloisio, A.A. (Aimee A.), Daly, M.B. (Mary), Damiola, F. (Francesca), Damirovna, S.D. (Sakaeva Dina), Dansonka-Mieszkowska, A. (Agnieszka), Dao, F. (Fanny), Davidson, R. (Rosemarie), DeFazio, A. (Anna), Delnatte, C.D. (Capucine), Doheny, K.F. (Kimberly), Díez, O. (Orland), Ding, Y.C. (Yuan Chun), Doherty, J.A. (Jennifer), Domchek, S.M. (Susan), Dorfling, C.M. (Cecilia), Dörk, T. (Thilo), Dossus, L. (Laure), Duran, M. (Mercedes), Dürst, M. (Matthias), Dworniczak, B. (Bernd), Eccles, D. (Diana), Edwards, T. (Todd), Eeles, R. (Rosalind), Eilber, U. (Ursula), Ejlertsen, B. (Bent), Ekici, A.B. (Arif), Ellis, S. (Steve), Elvira, M. (Mingajeva), Eng, K.H. (Kevin H.), Engel, C. (Christoph), Evans, D.G. (Gareth), Fasching, P.A. (Peter), Ferguson, S. (Sarah), Ferrer, S.F., Flanagan, J.M. (James), Fogarty, Z.C. (Zachary C.), Fortner, R.T. (Renée T.), Fostira, F. (Florentia), Foulkes, W.D. (William D.), Fountzilas, G. (George), Fridley, B.L. (Brooke), Friebel, M.O.W. (Mark ), Friedman, E. (Eitan), Frost, D. (Debra), Ganz, P.A. (Patricia), Garber, J. (Judy), García, M.J. (María J.), Garcia-Barberan, V. (Vanesa), Gehrig, P.A. (Paola A.), Gentry-Maharaj, A. (Aleksandra), Gerdes, A-M. (Anne-Marie), Giles, G.G. (Graham G.), Glasspool, R. (Rosalind), Glendon, G. (Gord), Godwin, A.K. (Andrew K.), Radice, P. (Paolo), Goranova, T. (Teodora), Gore, M. (Martin), Greene, M.H. (Mark H.), Gronwald, J. (Jacek), Gruber, S.B. (Stephen), Hahnen, E. (Eric), Haiman, C.A. (Christopher), Håkansson, N. (Niclas), Hamann, U. (Ute), Hansen, T.V.O. (Thomas V.O.), Harrington, P.A. (Patricia A.), Harris, H.R. (Holly), Hauke, J. (Jan), Hein, A. (Alexander), Henderson, A. (Alex), Hildebrandt, M.A.T. (Michelle A.T.), Hillemanns, P. (Peter), Hodgson, S. (Shirley), Høgdall, C.K. (Claus), Høgdall, E. (Estrid), Hogervorst, F.B.L. (Frans B. L.), Holland, H. (Helene), Hooning, M.J. (Maartje J.), Hosking, K. (Karen), Huang, R.-Y. (Ruea-Yea), Hulick, P.J. (Peter), Hung, J. (Jillian), Hunter, D.J. (David J.), Huntsman, D.G. (David G.), Huzarski, T. (Tomasz), Imyanitov, E.N. (Evgeny), Isaacs, C. (Claudine), Iversen, E. (Erik), Izatt, L. (Louise), Izquierdo, A. (A.), Jakubowska, A. (Anna), James, P. (Paul), Janavicius, R. (Ramunas), Jernetz, M. (Mats), Jensen, A. (Allan), Jensen, U.B., John, E.M. (Esther), Johnatty, S.E. (Sharon), Jones, M.E. (Michael E.), Kannisto, P. (Päivi), Karlan, B.Y. (Beth), Karnezis, A. (Anthony), Kast, K. (Karin), Kennedy, C.J. (Catherine J.), Khusnutdinova, E.K. (Elza), Kiemeney, L.A.L.M. (Bart), Kiiski, J.I. (Johanna I.), Kim, S.-W. (Sung-Won), Kjaer, M. (Michael), Köbel, M. (Martin), Kopperud, R.K. (Reidun K.), Kruse, T.A. (Torben), Kupryjanczyk, J. (Jolanta), Kwong, A. (Ava), Laitman, Y. (Yael), Lambrechts, D. (Diether), Larrañaga, N. (Nerea), Larson, M.C. (Melissa), Lazaro, C. (Conxi), Le, N.D. (Nhu D.), Le Marchand, L. (Loic), Lee, J.W. (Jong Won), Lele, S.B. (Shashikant B.), Leminen, A. (Arto), Leroux, D. (Dominique), Lester, J. (Jenny), Lesueur, F. (Fabienne), Levine, D.A. (Douglas), Liang, D. (Dong), Liebrich, C. (Clemens), Lilyquist, J. (Jenna), Lipworth, L. (Loren), Lissowska, J. (Jolanta), Lu, K.H. (Karen), Lubinski, J. (Jan), Luccarini, C. (Craig), Lundvall, L. (Lene), Mai, P.L. (Phuong), Mendoza-Fandiño, G. (Gustavo), Manoukian, S. (Siranoush), Massuger, L.F. (Leon), May, T. (Taymaa), Mazoyer, S. (Sylvie), McAlpine, J.N. (Jessica N.), McGuire, V. (Valerie), McLaughlin, J. (John), McNeish, I. (Iain), Meijers-Heijboer, E.J. (Hanne), Meindl, A. (Alfons), Menon, U. (Usha), Mensenkamp, A.R. (Arjen R.), Merritt, M.A. (Melissa A.), Milne, R.L. (Roger), Mitchell, G. (Gillian), Modugno, F. (Francesmary), Moes-Sosnowska, J. (Joanna), Moffitt, M. (Melissa), Montagna, M. (Marco), Moysich, K.B. (Kirsten), Mulligan, A.M. (Anna Marie), Musinsky, J. (Jacob), Nathanson, K.L. (Katherine), Nedergaard, L. (Lotte), Ness, R.B. (Roberta), Neuhausen, S.L. (Susan), Nevanlinna, H. (Heli), Niederacher, D. (Dieter), Nussbaum, R. (Robert), Odunsi, K. (Kunle), Olah, E. (Edith), Olopade, O.I. (Olofunmilayo), Olsson, H. (Håkan), Olswold, C. (Curtis), O'Malley, D.M. (David M.), Ong, K.-R. (Kai-Ren), Onland-Moret, N.C. (Charlotte), Orr, N. (Nick), Orsulic, S. (Sandra), Osorio, A. (Ana), Palli, D. (Domenico), Papi, L. (Laura), Park-Simon, T.-W., Paul, J. (James), Pearce, C.L. (Celeste), Pedersen, I.S. (Inge Søkilde), Peeters, P.H.M., Peissel, B. (Bernard), Peixoto, A. (Ana), Pejovic, T. (Tanja), Pelttari, L.M. (Liisa M.), Permuth, J.B. (Jennifer B.), Peterlongo, P. (Paolo), Pezzani, L. (Lidia), Pfeiler, G. (Georg), Phillips, K.-A. (Kelly-Anne), Piedmonte, M. (Marion), Pike, M.C. (Malcolm), Piskorz, A.M. (Anna M.), Poblete, S.R. (Samantha R.), Pócza, T. (Tímea), Poole, E.M. (Elizabeth M.), Poppe, B. (Bruce), Porteous, M.E. (Mary), Prieur, F. (Fabienne), Prokofyeva, D. (Darya), Pugh, E. (Elizabeth), Pujana, M.A. (Miquel Angel), Pujol, P. (Pascal), Rantala, J. (Johanna), Rappaport-Fuerhauser, C. (Christine), Rennert, G. (Gad), Rhiem, K. (Kerstin), Rice, P. (Patricia), Richardson, A.L. (Andrea), Robson, M. (Mark), Rodriguez, G.C. (Gustavo), Rodríguez-Antona, C. (Cristina), Romm, J. (Jane), Rookus, M.A. (Matti), Rossing, M.A. (Mary Anne), Rothstein, J.H. (Joseph H.), Rudolph, A. (Anja), Runnebaum, I.B. (Ingo), Salvesen, H.B. (Helga), Sandler, D.P. (Dale P.), Schoemaker, M.J. (Minouk J.), Senter, L. (Leigha), Setiawan, V.W. (V. Wendy), Severi, G. (Gianluca), Sharma, P. (Priyanka), Shelford, T. (Tameka), Siddiqui, N. (Nadeem), Side, L. (Lucy), Sieh, W. (Weiva), Singer, C.F. (Christian), Sobol, H. (Hagay), Song, H. (Honglin), Southey, M.C. (Melissa), Spurdle, A.B. (Amanda), Stadler, Z. (Zsofia), Steinemann, D. (Doris), Stoppa-Lyonnet, D. (Dominique), Sucheston-Campbell, L.E. (Lara E.), Sukiennicki, G. (Grzegorz), Sutphen, R. (Rebecca), Sutter, C. (Christian), Swerdlow, A.J. (Anthony ), Szabo, C. (Csilla), Szafron, L. (Lukasz), Tan, Y.Y. (Yen Y.), Taylor, J.A. (Jack A.), Tea, M.-K., Teixeira, P.J., Teo, S.-H. (Soo-Hwang), Terry, K.L. (Kathryn L.), Thompson, P.J. (Pamela J.), Thomsen, L.C.V. (Liv Cecilie Vestrheim), Thull, D.L. (Darcy L.), Tihomirova, L. (Laima), Tinker, A.V. (Anna V.), Tischkowitz, M. (Marc), Tognazzo, S. (Silvia), Toland, A.E. (Amanda Ewart), Tone, A. (Alicia), Trabert, B. (Britton), Travis, S.P.L. (Simon), Trichopoulou, A. (Antonia), Tung, N. (Nadine), Tworoger, S. (Shelley), Van Altena, A.M. (Anne M.), Van Den Berg, D. (David), Van Der Hout, A.H. (Annemarie H.), Luijt, R.B. (Rob) van der, Van Heetvelde, M. (Mattias), Van Nieuwenhuysen, E. (Els), Rensburg, E.J. (Elizabeth) van, Vanderstichele, A. (Adriaan), Varon-Mateeva, R. (Raymonda), Vega, A. (Ana), Edwards, D.V. (Digna Velez), Vergote, I., Vierkant, R.A. (Robert), Vijai, J. (Joseph), Vratimos, A. (Athanassios), Walker, L.J. (Lisa), Walsh, C. (Christine), Wand, D. (Dorothea), Wang-Gohrke, S. (Shan), Wappenschmidt, B. (Barbara), Webb, P.M. (Penelope M.), Weinberg, C.R. (Clarice R.), Weitzel, J.N. (Jeffrey), Wentzensen, N. (N.), Whittemore, A.S. (Alice), Wijnen, J.T. (Juul), Wilkens, L.R. (Lynne), Wolk, K. (Kerstin), Woo, M. (Michelle), Wu, X. (Xifeng), Wu, A.H. (Anna), Yang, H.P. (Hannah), Yannoukakos, D. (Drakoulis), Ziogas, A. (Argyrios), Zorn, K.K. (Kristin K.), Narod, S.A. (Steven A.), Easton, D.F. (Douglas), Amos, W., Schildkraut, J.M. (Joellen), Ramus, S.J. (Susan), Ottini, L. (Laura), Goodman, M.T. (Marc), Park, S.K. (Sue K.), Kelemen, L.E. (Linda), Risch, H. (Harvey), Thomassen, M. (Mads), Offit, K. (Kenneth), Simard, J. (Jacques), Schmutzler, R.K. (Rita), Hazelett, D. (Dennis), Monteiro, A.N.A. (Alvaro N.), Couch, F.J. (Fergus), Berchuck, A. (Andrew), Chenevix-Trench, G. (Georgia), Goode, E.L. (Ellen), Sellers, T.F., Gayther, S.A. (Simon), Antoniou, A.C. (Antonis), and Pharoah, P.D.P. (Paul)
- Abstract
To identify common alleles associated with different histotypes of epithelial ovarian cancer (EOC), we pooled data from multiple genome-wide genotyping projects totaling 25,509 EOC cases and 40,941 controls. We identified nine new susceptibility loci for different EOC histotypes: six for serous EOC histotypes (3q28, 4q32.3, 8q21.11, 10q24.33, 18q11.2 and 22q12.1), two for mucinous EOC (3q22.3 and 9q31.1) and one for endometrioid EOC (5q12.3). We then performed meta-analysis on the results for high-grade serous ovarian cancer with the results from analysis of 31,448 BRCA1 and BRCA2 mutation carriers, including 3,887 mutation carriers with EOC. This identified three additional susceptibility loci at 2q13, 8q24.1 and 12q24.31. Integrated analyses of genes and regulatory biofeatures at each locus predicted candidate susceptibility genes, including OBFC1, a new candidate susceptibility gene for low-grade and borderline serous EOC.
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- 2017
- Full Text
- View/download PDF
27. A meta-analysis of individual participant data reveals an association between circulating levels of IGF-I and prostate cancer risk
- Author
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Travis, S.P.L. (Simon), Appleby, P.N. (Paul N.), Martin, R.M. (Richard M.), Holly, J.M.P. (Jeff), Albanes, D. (Demetrius), Black, A., Bueno-De-Mesquita, H.B. (H. Bas), Chan, J.M. (June M.), Chen, C. (Chu), Chirlaque, M.D. (M.), Cook, M.B. (Michael B.), Deschasaux, M. (Mélanie), Donovan, J. (Jenny), Ferrucci, L. (Luigi), Galan, P. (Pilar), Giles, G.G. (Graham), Giovannucci, E.L. (Edward L.), Gunter, M.J. (Marc J.), Habel, L.A. (Laurel A.), Hamdy, F. (Freddie), Helzlsouer, K.J. (Kathy J.), Hercberg, S. (Serge), Hoover, R.N. (Robert), Janssen, J.A.M.J.L. (Joop), Kaaks, R. (Rudolf), Kubo, T. (Tatsuhiko), Le Marchand, L. (Loic), Metter, E.J. (E. Jeffrey), Mikami, K. (Kazuya), Morris, J.K. (Joan K.), Neal, D.E. (David E.), Neuhouser, M.L. (Marian L.), Ozasa, K. (Kotaro), Palli, D. (Domenico), Platz, E.A. (Elizabeth A.), Pollak, M.N. (Michael), Price, A.J. (Alison J.), Roobol-Bouts, M.J. (Monique), Schaefer, C. (Catherine), Schenk, J.M. (Jeannette M.), Severi, G. (Gianluca), Stampfer, M.J. (Meir J.), Stattin, P. (Pär), Tamakoshi, A. (Akiko), Tangen, C.M. (Catherine M.), Touvier, M. (Mathilde), Wald, A. (Anna), Weiss, N.S. (Noel S.), Ziegler, R.G. (Regina), Key, T. (Tim), Allen, N.E. (Naomi), Travis, S.P.L. (Simon), Appleby, P.N. (Paul N.), Martin, R.M. (Richard M.), Holly, J.M.P. (Jeff), Albanes, D. (Demetrius), Black, A., Bueno-De-Mesquita, H.B. (H. Bas), Chan, J.M. (June M.), Chen, C. (Chu), Chirlaque, M.D. (M.), Cook, M.B. (Michael B.), Deschasaux, M. (Mélanie), Donovan, J. (Jenny), Ferrucci, L. (Luigi), Galan, P. (Pilar), Giles, G.G. (Graham), Giovannucci, E.L. (Edward L.), Gunter, M.J. (Marc J.), Habel, L.A. (Laurel A.), Hamdy, F. (Freddie), Helzlsouer, K.J. (Kathy J.), Hercberg, S. (Serge), Hoover, R.N. (Robert), Janssen, J.A.M.J.L. (Joop), Kaaks, R. (Rudolf), Kubo, T. (Tatsuhiko), Le Marchand, L. (Loic), Metter, E.J. (E. Jeffrey), Mikami, K. (Kazuya), Morris, J.K. (Joan K.), Neal, D.E. (David E.), Neuhouser, M.L. (Marian L.), Ozasa, K. (Kotaro), Palli, D. (Domenico), Platz, E.A. (Elizabeth A.), Pollak, M.N. (Michael), Price, A.J. (Alison J.), Roobol-Bouts, M.J. (Monique), Schaefer, C. (Catherine), Schenk, J.M. (Jeannette M.), Severi, G. (Gianluca), Stampfer, M.J. (Meir J.), Stattin, P. (Pär), Tamakoshi, A. (Akiko), Tangen, C.M. (Catherine M.), Touvier, M. (Mathilde), Wald, A. (Anna), Weiss, N.S. (Noel S.), Ziegler, R.G. (Regina), Key, T. (Tim), and Allen, N.E. (Naomi)
- Abstract
The role of insulin-like growth factors (IGF) in prostate cancer development is not fully understood. To investigate the association between circulating concentrations of IGFs (IGF-I, IGF-II, IGFBP-1, IGFBP-2, and IGFBP-3) and prostate cancer risk, we pooled individual participant data from17 prospective and two cross-sectional studies, including up to 10,554 prostate cancer cases and 13,618 control participants. Conditional logistic regression was used to estimate the ORs for prostate cancer based on the study-specific fifth of each analyte. Overall, IGF-I, IGF-II, IGFBP-2, and IGFBP-3 concentrations were positively associated with prostate cancer risk (Ptrend all ≤ 0.005), and IGFBP-1 was inversely associated weakly with risk (Ptrend = 0.05). However, heterogeneity between the prospective and cross-sectional studies was evident (Pheterogeneity = 0.03), unless the analyses were restricted to prospective studies (with the exception of IGF-II, Pheterogeneity = 0.02). For prospective studies, the OR for men in the hi
- Published
- 2016
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28. MANAGED CARE FOR DISTAL ULCERATIVE COLITIS: PRELIMINARY RESULTS
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Travis, S.P.L., Dannatt, E., McGovern, D.P.B., Beale, A., and Jagadeesan, S.
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Gastrointestinal diseases -- Research ,Health ,Research - Abstract
Background: The prevalence of refractory distal colitis is uncertain, because management of distal colitis varies. With the introduction of clinical governance, we adopted a staged management protocol. Methods: Patients with [...]
- Published
- 2001
29. Hepatocellular carcinoma surveillance: is risk stratification the way forward? (Journal Scan)
- Author
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Aithal, G., Logan, R.F.A., Penman, I.D., and Travis, S.P.L.
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Hepatoma -- Risk factors -- Demographic aspects ,Health risk assessment -- Methods ,Health ,Risk factors ,Demographic aspects ,Methods - Abstract
Velazquez RF, Rodriguez M, Navascues CA, et al. Prospective analysis of risk factors for hepatocellular carcinoma in patients with liver cirrhosis. Hepatology 2003;37:520-7. Hepatocellular cancer (HCC) meets several of the [...]
- Published
- 2003
30. Which 5-ASA? (Therapy Update)
- Author
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Travis, S.P.L.
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Ulcerative colitis -- Care and treatment ,Anti-inflammatory drugs -- Product introduction -- Physiological aspects ,Health ,Product introduction ,Care and treatment ,Physiological aspects - Abstract
When Asacol commands 65% of the UK market, can so many British gastroenterologists be wrong? Possibly. The market leader in France is Pentasa (72%) and is Salofalk in Germany (57%). [...]
- Published
- 2002
31. OP001 Innate lymphoid cells accumulate in IBD
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Geremia, A., primary, Arancibia, C., additional, Gwela, A., additional, Chapman, R.W., additional, Travis, S.P.L., additional, and Powrie, F., additional
- Published
- 2014
- Full Text
- View/download PDF
32. The role of immunization in reducing infections in patients with IBD
- Author
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UCL - (MGD) Service de gastro-entérologie, Rahier, Jean-François, Colombel, J.-F., Travis, S.P.L., UCL - (MGD) Service de gastro-entérologie, Rahier, Jean-François, Colombel, J.-F., and Travis, S.P.L.
- Abstract
Vaccine-preventable diseases are a major source of morbidity and mortality in patients with altered immune competence. Patients with IBD are considered to be significantly immunocompromised hosts, mainly because of the immunomodulatory medications they take. Routine and specific immunizations are important to consider in this population. Whenever possible, immunization should be considered prior to administering any immunomodulator in order to optimize the immunological response. Prior to foreign travel, IBD patients are best advised by travel medicine specialists familiar with this complex and vulnerable population.
- Published
- 2009
33. Oral and gastrointestinal manifestations of epidermolysis bullosa
- Author
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Travis, S.P.L., McGrath, J.A., Turnbull, A.J., Schofield, O.M., Chan, O., O'Connor, A. Fitzgerald, Mayou, B., Eady, R.A.J., and Thompson, R.P.H.
- Subjects
Epidermolysis bullosa -- Physiological aspects - Published
- 1992
34. Corrigendum to “European-evidence-based consensus on the management of ulcerative colitis: Current management” [J Crohns & Colitis 2 (2008) 24–62]
- Author
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Travis, S.P.L., primary, Stange, E.F., additional, Lémann, M., additional, Øresland, T., additional, Bemelman, W.A., additional, Chowers, Y., additional, Colombel, J.F., additional, D'Haens, G., additional, Ghosh, S., additional, Marteau, P., additional, Kruis, W., additional, Mortensen, N.J.McC., additional, Penninckx, F., additional, and Gassull, M., additional
- Published
- 2008
- Full Text
- View/download PDF
35. P235 PREVALENCE AND DETERMINANTS OF PSC IN A COHORT OF PATIENTS WITH INFLAMMATORY BOWEL DISEASE AND NORMAL LIVER FUNCTION TESTS
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Bungay, H.K., primary, Buchel, O.C., additional, Travis, S.P.L., additional, Cummings, F., additional, and Chapman, R.W.G., additional
- Published
- 2008
- Full Text
- View/download PDF
36. P190 THE PATTERN AND OUTCOME OF ACUTE SEVERE ULCERATIVE COLITIS
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Dinesen, L.C., primary, Nedeljkovic Protic, M., additional, Walsh, A.J., additional, Cummings, F., additional, Ahmad, T., additional, and Travis, S.P.L., additional
- Published
- 2008
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- View/download PDF
37. Predicting outcome in severe ulcerative colitis
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Travis, S.P.L., primary
- Published
- 2004
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38. Iron deficiency--should it be investigated? (Journal Scan)
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Aithal, G., Logan, R.F.A., Penman, I.D., and Travis, S.P.L.
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Gastrointestinal cancer -- Diagnosis ,Digestive system cancer -- Diagnosis ,Iron deficiency anemia -- Causes of -- Diagnosis ,Health ,Diagnosis ,Causes of - Abstract
Ioannou GN, Rockey DC, Bryson CL, et al. Iron deficiency and gastrointestinal malignancy: a population-based cohort study. Am J Med 2002;113:276-80. Iron deficiency anaemia (IDA) is common; population surveys have [...]
- Published
- 2003
39. Common bile duct stones--cut or stretch? (Journal Scan)
- Author
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Aithal, G., Logan, R.F.A., Penman, I.D., and Travis, S.P.L.
- Subjects
Gallstones -- Care and treatment -- Patient outcomes ,Balloon dilatation -- Methods ,Health - Abstract
A Fujita N, Maguchi H, Komatsu Y, et al. Endoscopic sphincterotomy and endoscopic papillary balloon dilatation for bile duct stones: a prospective randomised controlled multicenter trial. Gastrointest Endosc 2003;57:151-5. Endoscopic [...]
- Published
- 2003
40. Natalizumab for active Crohn's disease. (Journal Scan)
- Author
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Aithal, G., Logan, R.F.A., Penman, I.D., and Travis, S.P.L.
- Subjects
Integrins -- Dosage and administration -- Evaluation ,Crohn's disease -- Drug therapy ,Health ,Drug therapy ,Evaluation ,Dosage and administration - Abstract
A Ghosh, S, Goldin E, Gordon FH, et al. Natalizumab for active Crohn's disease. N Engl J Med 2003;348:24-32. Natalizumab, an [α.sub.4] integrin-inhibitor of lymphocyte trafficking, is effective for active [...]
- Published
- 2003
41. Azathioprine intolerance in patients with IBD may be imidazole-related and is independent of TPMT activity
- Author
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McGovern, D.P.B., primary, Travis, S.P.L., additional, Duley, J., additional, Shobowale-Bakre, El M., additional, and Dalton, H.R., additional
- Published
- 2002
- Full Text
- View/download PDF
42. Dose escalation of 5ASA: does it work?
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Travis, S.P.L.
- Published
- 2005
- Full Text
- View/download PDF
43. Salicylates for inflammatory bowel disease
- Author
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Travis, S.P.L., primary and Jewell, D.P., additional
- Published
- 1994
- Full Text
- View/download PDF
44. The role of platelet-activating factor in the pathogenesis of gastrointestinal disease
- Author
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Travis, S.P.L., primary and Jewell, D.P., additional
- Published
- 1994
- Full Text
- View/download PDF
45. Salicylates for ulcerative colitis—their mode of action
- Author
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Travis, S.P.L., primary and Jewell, D.P., additional
- Published
- 1994
- Full Text
- View/download PDF
46. Mechanisms of diarrhea in ulcerative colitis
- Author
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Travis, S.P.L., primary and Jewell, D.P., additional
- Published
- 1993
- Full Text
- View/download PDF
47. Long-term outcome after admission for acute severe ulcerative colitis in Oxford: The 1992-1993 cohort.
- Author
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Bojic, D., Radojicic, Z., Nedeljkovic-Protic, M., Al-Ali, M., Jewell, D.P., and Travis, S.P.L.
- Published
- 2009
- Full Text
- View/download PDF
48. "CARBOLOADING" AND DEHYDRATION
- Author
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Travis, S.P.L., primary and Templer, M.J., additional
- Published
- 1981
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- View/download PDF
49. DEHYDRATION IN MARATHON RUNNERS
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Wartnaby, KathleenM., primary and Travis, S.P.L., additional
- Published
- 1981
- Full Text
- View/download PDF
50. Which 5-ASA?
- Author
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Travis, S.P.L.
- Subjects
- *
METALLOPROTEINASES , *T cells , *IN situ hybridization - Abstract
Background and aim: Matrix metalloproteinases (MMPs) have been implicated in tissue remodelling and ulceration in inflammatory bowel disease and coeliac disease. Studies to date have concluded that stromelysin 1 is functionally involved in mucosal degradation. However, there are many other MMPs whose function in the gut is currently unknown. This work had two aims: firstly, to use gene array technology to measure changes in MMP and tissue inhibitor of metalloproteinase (TIMP) expression in a model of T cell mediated injury in the gut, and secondly, to correlate data from gene arrays with that generated by in situ hybridisation. Methods: T cells in explants of human fetal gut were activated with pokeweed mitogen or anti-CD3 plus interleukin 12. Gene array analysis and in situ hybridisation were performed to investigate changes in MMP gene expression. Results: Both gene array analysis and in situ hybridisation indicated marked upregulation of stromelysin 2 and macrophage metalloelastase expression in the explants associated with mucosal destruction. The arrays also confirmed our previous observation that interstitial collagenase (MMP-1), stromelysin 1 (MMP-3), and gelatinase B (MMP-9) are upregulated but there was no change in MMP-2, -7, -8, -9, -11, -13, -14-17, or -19. Following T cell activation, transcripts for TIMPs were reduced. Conclusions: These results show that there is differential upregulation of MMPs during T cell responses in the gut and suggest that further studies on the role of stromelysin 2 and macrophage metalloelastase may show that they have a functional role. In addition, the increase in MMPs and reduction in TIMPs suggest that the protease/antiprotease balance in the mucosa may determine the extent of mucosal degradation. [ABSTRACT FROM AUTHOR]
- Published
- 2002
- Full Text
- View/download PDF
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