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296 results on '"Traves V"'

1. Análisis multicéntrico del manejo quirúrgico y tratamiento adyuvante de los pacientes con melanoma y positividad en la biopsia selectiva del ganglio centinela

Author

Samaniego-González, E., Podlipnik, S., Ribero, S., Nagore, E., Boada, A., Cañueto, J., Paradela, S., de Unamuno, B., Rodríguez-Jiménez, P., Puig, S., Malvehy, J., Carrera, C., Roccuzzo, G., Requena, C., Manrique-Silva, E., Richarz, N., Ruiz-Villanueva, A., Través, V., España-Fernández, S., Botella-Estrada, R., González-Morán, M.A., and Tejera-Vaquerizo, A.

Published
2024
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40. Distribution and clinical role of KIT gene mutations in melanoma according to subtype: a study of 492 Spanish patients

Author

Millán-Esteban D, García-Casado Z, Manrique-Silva E, Virós A, Kumar R, Furney S, López-Guerrero JA, Requena C, Bañuls J, Traves V, and Nagore E

Subjects
subtype, melanoma, KIT, aggressiveness, mutation
Abstract

BACKGROUND: KIT mutations are primarily associated with acral and mucosal melanoma, and have been reported to show higher prevalence in chronic sun-damaged (CSD) than non-CSD melanomas. OBJECTIVES: To investigate the prevalence of KIT mutations in melanoma according to subtype, and determine the clinical role of such mutations. MATERIALS & METHODS: We present results from a study of a Spanish population of 492 melanomas, classified according to the latest World Health Organization (WHO) guidelines. We analysed the mutational status of KIT and correlated with different clinical variables related to sun exposure and family history. RESULTS: KIT mutations were significantly more frequent in acral (3/36; 8.3%) and mucosal (4/8; 50%) melanomas than non-acral cutaneous melanomas. No significant difference was observed in KIT mutational status between CSD and non-CSD melanomas. CONCLUSION: Our results suggest that KIT mutations in melanoma tumours are unrelated to the development of nevi or chronic sun damage, but their presence is associated with aggressive melanomas which show ulceration, vascular invasiveness, and increased Breslow thickness. These findings are consistent with those reported by The Cancer Genome Atlas network.

Published
2021

41. Angiosarcomas: histology, immunohistochemistry and molecular insights with implications for differential diagnosis

Author

Machado I, Giner F, Lavernia J, Cruz J, Traves V, Requena C, Llombart B, López-Guerrero JA, and Llombart-Bosch A

Subjects
Molecular biology, Differential diagnosis, Angiosarcomas, Immunohistochemistry
Abstract

Angiosarcomas (AS) represent a heterogenous group of tumors with variable clinical presentation. AS share an important morphologic and immunohistochemical overlap with other sarcomas, hence the differential diagnosis is challenging, especially in poorly-differentiated tumors. Although molecular studies provide significant clues, especially in the differential diagnosis with other vascular neoplasms, a thorough hematoxylin and eosin analysis remains an essential tool in AS diagnosis. In this review, we discuss pathological and molecular insights with emphasis on implications for differential diagnosis in cutaneous, breast, soft tissue and visceral AS.

Published
2021

42. Mutational Characterization of Cutaneous Melanoma Supports Divergent Pathways Model for Melanoma Development

Author

Millan-Esteban D, Pena-Chilet M, Garcia-Casado Z, Manrique-Silva E, Requena C, Banuls J, Lopez-Guerrero J, Rodriguez-Hernandez A, Traves V, Dopazo J, Viros A, Kumar R, and Nagore E

Subjects
melanoma, etiopathogeny, mutations, neoplasms
Abstract

Simple Summary The divergent pathway model established at least two approaches for melanoma development. One was related to a propensity to melanocytic proliferation (nevogenic), and the other was associated with an accumulation of solar damage (CSD). We conducted a retrospective study to examine whether this model had a molecular support using sequencing and bioinformatic tools on a set of cutaneous melanomas corresponding to these two groups. We found that the nevogenic melanomas were associated with mutations in BRAF, while the CSD melanomas were associated with mutations in NF1, ROS1, GNA11, and RAC1. We concluded that nevogenic and CSD melanomas constitute two different biological entities. According to the divergent pathway model, cutaneous melanoma comprises a nevogenic group with a propensity to melanocyte proliferation and another one associated with cumulative solar damage (CSD). While characterized clinically and epidemiologically, the differences in the molecular profiles between the groups have remained primarily uninvestigated. This study has used a custom gene panel and bioinformatics tools to investigate the potential molecular differences in a thoroughly characterized cohort of 119 melanoma patients belonging to nevogenic and CSD groups. We found that the nevogenic melanomas had a restricted set of mutations, with the prominently mutated gene being BRAF. The CSD melanomas, in contrast, showed mutations in a diverse group of genes that included NF1, ROS1, GNA11, and RAC1. We thus provide evidence that nevogenic and CSD melanomas constitute different biological entities and highlight the need to explore new targeted therapies.

Published
2021

47. Angiosarcomas: histology, immunohistochemistry and molecular insights with implications for differential diagnosis

Author

Machado I, Giner F, Lavernia J, Cruz J, Traves V, Requena C, Llombart B, López-Guerrero JA, and Llombart-Bosch A

Subjects
Molecular biology, Differential diagnosis, Angiosarcomas, Immunohistochemistry
Abstract

Angiosarcomas (AS) represent a heterogenous group of tumors with variable clinical presentation. AS share an important morphologic and immunohistochemical overlap with other sarcomas, hence the differential diagnosis is challenging, especially in poorly-differentiated tumors. Although molecular studies provide significant clues, especially in the differential diagnosis with other vascular neoplasms, a thorough hematoxylin and eosin analysis remains an essential tool in AS diagnosis. In this review, we discuss pathological and molecular insights with emphasis on implications for differential diagnosis in cutaneous, breast, soft tissue and visceral AS.

Published
2020

48. Corrigendum to 'Factors associated with sentinel lymph node status and prognostic role of completion lymph node dissection for thick melanoma' [Eur J Surg Oncol 46 2 (2019) 263–271] (European Journal of Surgical Oncology (2020) 46(2) (263–271), (S0748798319308807), (10.1016/j.ejso.2019.09.189))

Author

Boada, A., Tejera-Vaquerizo, A., Ribero, S., Puig, S., Moreno-Ramirez, D., Quaglino, P., Osella-Abate, S., Cassoni, P., Malvehy, J., Carrera, C., Pigem, R., Barreiro-Capurro, A., Requena, C., Traves, V., Manrique-Silva, E., Fernandez-Orland, A., Ferrandiz, L., Garcia-Senosiain, O., Fernandez-Figueras, M. T., Ferrandiz, C., Nagore, E., Espinosa, N., Gimenez, P., Perez, J., Podlipnik, S., Rull, R., Vidal-Sicart, S., Yelamos, O., Fiero, M. T., Bolumar, I., Pla, A., Quer-Pi sunyer, A., Manzano, J. L., Pascual, I., Jaka, A., and Sanchez-Lucas, M.

Published
2020

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