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Summary: Background: Mucositis is a common and highly impactful side effect of conventional and emerging cancer therapy and thus the subject of intense investigation. Although common practice, mucositis assessment is heterogeneously adopted and poorly guided, impacting evidence synthesis and translation. The Multinational Association of Supportive Care in Cancer (MASCC) Mucositis Study Group (MSG) therefore aimed to establish expert recommendations for how existing mucositis assessment tools should be used, in clinical care and trials contexts, to improve the consistency of mucositis assessment. Methods: This study was conducted over two stages (January 2022–July 2023). The first phase involved a survey to MASCC-MSG members (January 2022–May 2022), capturing current practices, challenges and preferences. These then informed the second phase, in which a set of initial recommendations were prepared and refined using the Delphi method (February 2023–May 2023). Consensus was defined as agreement on a parameter by >80% of respondents. Findings: Seventy-two MASCC-MSG members completed the first phase of the study (37 females, 34 males, mainly oral care specialists). High variability was noted in the use of mucositis assessment tools, with a high reliance on clinician assessment compared to patient reported outcome measures (PROMs, 47% vs 3%, 37% used a combination). The World Health Organization (WHO) and Common Terminology Criteria for Adverse Events (CTCAE) scales were most commonly used to assess mucositis across multiple settings. Initial recommendations were reviewed by experienced MSG members and following two rounds of Delphi survey consensus was achieved in 91 of 100 recommendations. For example, in patients receiving chemotherapy, the recommended tool for clinician assessment in clinical practice is WHO for oral mucositis (89.5% consensus), and WHO or CTCAE for gastrointestinal mucositis (85.7% consensus). The recommended PROM in clinical trials is OMD/WQ for oral mucositis (93.3% consensus), and PRO-CTCAE for gastrointestinal mucositis (83.3% consensus). Interpretation: These new recommendations provide much needed guidance on mucositis assessment and may be applied in both clinical practice and research to streamline comparison and synthesis of global data sets, thus accelerating translation of new knowledge into clinical practice. Funding: No funding was received.

O presente estudo estabeleceu como objetivo identificar os impactos gerados a partir da implementação de um sistema de informação em uma agroindústria. Para alcançar este objetivo, a pesquisa, de natureza qualitativa, teve como instrumento de coleta de dados entrevistas semiestruturadas, realizadas com dois gestores de uma agroindústria localizada no Litoral Norte da Paraíba. Os dados coletados foram analisados por meio da técnica da análise de conteúdo, agrupando-os em categorias. A pesquisa apresentou, por meio das perspectivas dos gestores entrevistados, todo o processo de implementação, funcionalidades, impactos e desafios relacionados ao sistema utilizado pela empresa. Os resultados permitem concluir que o sistema adquirido apresenta diversos benefícios para a empresa, notadamente do ponto de vista de processos, produção e econômicos. Contudo, alguns desafios apontados pelos entrevistados, sobretudo diante da resistência dos usuários em utilizar o sistema, demonstram a necessidade de estabelecimento de uma política de tecnologia da informação na empresa, incluindo desde o planejamento participativo das necessidades de tecnologia, até os aspectos relacionados à avalição do desempenho do sistema.

This study aims to investigate the impact of national quality programs in mammography and technological advances in digital mammography units on the radiation doses delivered to women in Brazil. Radiation dose assessments in mammography units were conducted through a mail-based dosimetric system. For each unit of facilities that applied to one of the two national quality programs, a postal dosimetric system is dispatched, comprising an optically stimulated luminescent dosimeter (OSL) attached to the surface of a 4.0 cm thick polymethyl methacrylate (PMMA) phantom, simulating a compressed breast with 4.5 cm thickness. Testing instructions to expose the dosimetric phantom for assessing the mean glandular dose (MGD) are provided. Between 2012 and 2023, the programs evaluated the MGD in 1,687 mammography units of computed radiography (CR) and direct digital radiography (DR) technologies from 1,399 facilities located in all Brazilian regions. A total of 1,660 (70.5%) evaluations were carried out on CR technology mammography units and 696 (29.5%) on DR units, totaling 2,356 MGD evaluations. The overall average MGD was 1.60 ± 0.80 mGy, with 1.68 ± 0.83 mGy for CR technology and 1.42 ± 0.68 mGy for DR technology. A comparison of average MGD between the periods 2012 - 2018 and from 2019 onwards shows a dose reduction of 8.6% for CR systems and of 26.0% for DR systems (p = 0.000). As CR systems use analog mammography units, which did not undergo technological advances between the two periods, the reduction in doses observed is due to the actions of national quality certification programs and by using image plates for dual-sided reading or needle-based image plates. The reduction observed in DR systems is due to both national quality programs and technological advances in mammography units, especially the use of radiation beams generated by X-ray tubes with tungsten targets.

Introdução: Mulheres vivendo com HIV/AIDS possuem maior frequência de neoplasias anogenitais decorrentes da infecção pelo papilomavírus humano (HPV). A Organização Mundial da Saúde recomenda que o rastreio de câncer do colo do útero seja utilizado por testes moleculares que amplificam o material genético viral, como o HPV-DNA. Além da coleta por profissionais da saúde, a autocoleta de amostras vaginais consiste em uma ferramenta útil para ampliação do acesso à testagem. Objetivo: Descrever os resultados do estudo piloto que avaliou a aceitabilidade da autocoleta de amostra vaginal e aplicabilidade da oferta de testes HPV-DNA com autocoleta de amostras vaginais para mulheres vivendo com HIV/AIDS no Brasil. Métodos: Estudo transversal descritivo envolvendo mulheres vivendo com HIV/AIDS atendidas em oito serviços ambulatoriais distribuídos em todas as regiões do país no período de maio/2021 a maio/2022 e um laboratório central. Realizou-se a oferta de autocoleta vaginal e uma entrevista com as participantes sobre dados sociodemográficos e impressões da autocoleta. Resultados: No total, 1.919 mulheres vivendo com HIV/AIDS com média de 45 anos participaram do estudo. Houve detecção de algum tipo de HPV em 66% (1.267) dos casos. A maioria (71,9%) afirmou preferir a autocoleta à coleta de amostras por profissionais da saúde. Apenas 53,8% das participantes realizaram citologia na periodicidade adequada, conforme recomendação do protocolo. Conclusão: Os resultados poderão apoiar a implementação dos testes de biologia molecular para detecção de HPV em mulheres vivendo com HIV/AIDS, incluindo a possibilidade de autocoleta vaginal, promovendo a ampliação do acesso ao rastreamento de câncer do colo do útero. Palavras-chave: Soropositividade para HIV. Papillomavírus humano. Programas de rastreamento. Neoplasias do colo do útero. Serviços de saúde.

Introdução: Os cigarros eletrônicos, que foram introduzidos no mercado com a finalidade de auxiliar na cessação do tabagismo, está relacionado ao desenvolvimento da lesão pulmonar associada ao uso de cigarros eletrônicos e vaporizadores (Evali), principalmente na população jovem. Neste contexto, é imprescindível entender os mecanismos de lesão pulmonar produzidos pelo uso de cigarros eletrônicos, a fim de estabelecer os verdadeiros riscos da exposição a longo prazo a esses vapores. Objetivo: Elucidação dos mecanismos fisiopatológicos da Evali. Método: Revisão de literatura integrativa baseada no método PRISMA e busca nas bases de dados LILACS, PubMed, Embase, no período de 2003 a 2023. Foram selecionadas pesquisas experimentais e epidemiológicas de livre acesso na íntegra com abordagem na patogênese da Evali. Resultados: Os diferentes constituintes presentes no cigarro eletrônico estão envolvidos no desenvolvimento da Evali, visto que agem por diversos mecanismos, como: modificação na estrutura e funções do surfactante pulmonar, acúmulo de gotículas de óleo no muco e modificação da estrutura, função e quimiotaxia de células que compõem a imunidade inata, como os neutrófilos e macrófagos. Conclusões: O cigarro eletrônico induz a Evali por diferentes mecanismos em virtude da complexidade da composição de substâncias presentes nos vapores. O esclarecimento acerca dos mecanismos de lesão pulmonar é pertinente para nortear as agências regulatórias na aplicação de medidas mais rigorosas aos cigarros eletrônicos, a fim de reduzir os impactos da exposição e dos casos de morbimortalidade entre os jovens e adultos.

Abstract This study presents geophysical data from two passive seismic measurements conducted at two different sites in Antarctica. We analyzed the signals mainly in the frequency domain through the multitaper method to extract some spectral characteristics of the signals that would have been out of reach through the usual FFT approach. The power spectral density of the signals carries information about the processes that generated them, allowing its correlation with their source origin and type, either natural or anthropogenic. We deal with three different source types: calving, wind, and anthropogenic origins. The former is closely related to glacier dynamics, being modulated by the prevailing atmospheric processes. At both locations the wind noise is prevalent, complicating the analysis of other events like calving. We have used data classification, estimation of the source azimuth, and seismic apparent velocity to demonstrate the viability of using geophysical methods to study glacier elastic parameters and dynamics. Moreover, the calving rate can yield a wider and more independent understanding of glacier hydrodynamics and may help to estimate the future response of the polar areas to a changing environment.

IntroductionThis study aimed to describe the fixation location and the time of the longer fixation of expert and novice futsal coaches before the ball was in play in futsal set pieces.MethodsA total of 10 experts (ages 48 ± 5) and 10 novice coaches (ages 40 ± 7) participated in the study. They observed that 38 video clips were created to mimic the attack and defensive set-piece moments of the game. Data were collected in a standardized video analysis task using the pupil invisible eye tracker and processed through the pupil cloud platform. The Mann–Whitney test was conducted to evaluate differences in gaze duration between game moments (attack and defense set pieces) and groups (expert vs. novice). Gaze duration was also compared for gaze location between groups. For further comparisons, the game moments (attack and defense set pieces) and the gaze location were summarized in two-dimensional graphics using correspondence analysis.Results and discussionThe results revealed higher values of gaze duration for attack and defense set pieces for the group of experts than for novices. When considering gaze duration, expert coaches had higher values than novices for the attacker 3, defender 3, barrier 1st, and barrier 2nd gaze locations. The correspondence analysis showed different strategies of visual search and, consequently, gaze locations for attack and defense set pieces. In particular, there was different correspondence for free kicks between the level of expertise and gaze location, while corner and sideline kicks revealed some correspondence between the groups and the gaze location. In free kicks, coaches should be particularly concerned about the relationship between attacker and defender three and the barrier 1st and 2nd line positions. In corner and sideline kicks, coaches should be particularly aware of the relationship between attackers' and defenders' positions.

Abstract In Bandiagara, Mali, children experience on average two clinical malaria episodes per year. However, even in the same transmission area, the number of uncomplicated symptomatic infections, and their parasitemia, can vary dramatically among children. We simultaneously characterize host and parasite gene expression profiles from 136 Malian children with symptomatic falciparum malaria and examine differences in the relative proportion of immune cells and parasite stages, as well as in gene expression, associated with infection and or patient characteristics. Parasitemia explains much of the variation in host and parasite gene expression, and infections with higher parasitemia display proportionally more neutrophils and fewer T cells, suggesting parasitemia-dependent neutrophil recruitment and/or T cell extravasation to secondary lymphoid organs. The child’s age also strongly correlates with variations in gene expression: Plasmodium falciparum genes associated with age suggest that older children carry more male gametocytes, while variations in host gene expression indicate a stronger innate response in younger children and stronger adaptive response in older children. These analyses highlight the variability in host responses and parasite regulation during P. falciparum symptomatic infections and emphasize the importance of considering the children’s age when studying and treating malaria infections.

ABSTRACTAt a basic level, entrepreneurship refers to an individual or a small group of partners that intend to create a new business. Entrepreneurship is at the forefront of any competitive economy due to the creation of new products and services. In other words, entrepreneurship is associated with economic wealth, growth, and innovation. The usage of resources in the creation of new businesses needs to be rational because investors normally are risk averse, and the usage of resources must take into account the possible damage to the planet. In other words, entrepreneurs and the sustainability of the planet are interconnected. Beyond this, entrepreneurs need to take care of the corporate social responsibility of each new business, considering the interests of all stakeholders. Nevertheless, existing research has not shown in full all the research streams, how they interact with each other and their potential knowledge development. The methodological approach is based on a literature review using Scopus® databases under the PRISMA (Preferred Reporting Items for Systematic review and Meta-Analysis). This paper aims to identify research trends in the field through a Systematic Bibliometric Literature Review of social entrepreneurship and corporate social responsibility research, with a literature review based on SCOPUS, the world’s most important peer-reviewed database in the academic world, and using the PRISMA protocol, which contributes to an increased knowledge on the subject. The review includes 69 articles published in the Scopus® database, presenting up-to-date knowledge on the topic.

The objective of this study was to determine the etiology of febrile illnesses among patients from October 1, 1993 through September 30, 1999, in the urban community of Iquitos in the Amazon River Basin of Peru. Epidemiological and clinical data as well as blood samples were obtained from consenting patients at hospitals, health clinics and private residences. Samples were tested for arboviruses in cell cultures and for IgM and IgG antibodies by ELISA. Blood smears were examined for malaria, and sera were tested for antibodies to Leptospira spp. by ELISA and microscopic agglutination. Among 6,607 febrile patients studied, dengue viruses caused 14.6% of the cases, and Venezuelan equine encephalitis virus caused 2.5%, Oropouche virus 1.0%, Mayaro virus 0.4%, and other arboviruses caused 0.2% of the cases. Also, 22.9% of 4,844 patients tested were positive for malaria, and of 400 samples tested, 9% had evidence of acute leptospirosis. Although the study was not designed to assess the importance of these pathogens as a cause of human morbidity in the total population, these results indicate that arboviruses, leptospirosis, and malaria were the cause of approximately 50% of the febrile cases. Although the arboviruses that were diagnosed can produce asymptomatic infections, our findings increased the overall understanding of the relative health burden of these infections, as well as baseline knowledge needed for designing and implementing further studies to better assess the health impact and threat of these pathogens in the Amazon Basin of Peru.

Abstract: We evaluated the hypothesis of an association between excess mortality and political partisanship in Brazil using municipal death certificates registered in the Brazilian Ministry of Health database and first-round electoral results of Presidential elections in 2018 and 2022. Considering the former Brazilian President’s stance of discrediting and neglecting the severity of the pandemic, we expect a possible relationship between excessive mortality rates during the COVID-19 health crisis and the number of municipal votes for Bolsonaro. Our results showed that, in both elections, the first-round percentage of municipal votes for Bolsonaro was positively associated with the peaks of excess deaths across Brazilian municipalities in 2020 and 2021. Despite the excess mortality during the pandemic, the political loyalty to Bolsonaro remained the same during the electoral period of 2022. A possible explanation for this is linked to the Brazilian political scenario, which presents an environment of tribal politics and affective polarization.

IntroductionThe aim of this study was to analyze the effects of space and number of players manipulation on the external and internal load demands of youth futsal athletes.MethodsForty-two male U17 players (age = 15.62 ± 0.58 years) from three futsal teams participated in the study. In this cross-sectional study that lasted 8-week, the player's sample practiced six futsal tasks (T1–T6) and a futsal game played under the official rules (T7). From T1–T6, two task constraints were manipulated: (i) the number of players and, (ii) the space of play. The WIMU PRO™ Ultra-Wideband (UWB) tracking system was used to measure the external and internal load during the futsal tasks. External load was quantified using kinematic and mechanical variables extracted from positional data and, the internal load was quantified using Heart rate (HR) and rating of perceived exertion (RPE). Repeated measures ANOVA was used for comparison purposes.ResultsIn general, the results showed high external (total distance, distance 18.1–21, above 21 Km/h, and high intensity acceleration and deceleration, p

Objective This study was realized to evaluate the effects of supplementation with blends of water and fat-soluble vitamins on animal performance and carcass traits of young Nellore bulls. Methods Forty-three Nellore bulls, with an initial weight of 261±27.3 kg and a mean age of 8±1.0 months, were used. Five animals were slaughtered at the beginning of the experiment (reference group), to determine the initial empty body weight of the bulls that remained in the experiment. The remaining 38 bulls were fed ad libitum and distributed in a completely randomized design in a 2×2 factorial scheme, with or without supplementation of water-soluble (B-blend+ or B-blend−) and fat-soluble (ADE+ or ADE−) vitamin blends. Diets were isonitrogenous (120 g of crude protein/kg dry matter [DM] of total mixed ration) and consisted of a roughage:concentrate rate of 30:70 based on total DM of diet. The experiment lasted 170 days, with 30 days of adaptation and 140 days for data collection. At the beginning and end of the experimental period, the bulls were weighed to determine the average daily gain. To estimate the apparent digestibility of nutrients and microbial efficiency, spot collections of feces and urine were performed for five consecutive days. Results DM, ashes, organic matter, crude protein, ethereal extract, neutral detergent fiber corrected for residual ash and residual nitrogenous, and N intake and apparent digestibility were not influenced by vitamin supplementation, but total digestible nutrients intake and non-fibrous carbohydrates digestibility were influenced by B complex vitamin supplementation. Nitrogen balance, microbial efficiency, and performance data were not influenced (p>0.05) by vitamin supplementation. Conclusion Vitamin supplementation (a blend of water-soluble and fat-soluble vitamins or their combinations) does not influence the animal performance and carcass traits of young Nellore bulls.

(1) Background: Cleft lip and palate is the most common congenital malformation of the head and neck. After surgical closure, velopharyngeal dysfunction can arise, which has implications for phonation, sucking, swallowing, middle ear function, and interpersonal well-being. This case series aimed to present an adaptation of the conventional pharyngeal obturator design in order to allow its use with fixed orthodontic appliances. (2) Methods: A new custom-made pharyngeal obturator device was built in order to enable a correct function of the velopharyngeal valve. The fabrication of the plate was made by altering the conventional Hawley retainer, replacing the Adams hooks with 0.9 mm spherical hooks and removing the buccal arch. (3) Results: The new pharyngeal obturator design was used in six cleft patients with fixed orthodontic appliances. The appliance was well tolerated and there was a slight improvement in auditory-perceptive evaluations. (4) Conclusions: The new pharyngeal bulb design proved to have good retention during fixed orthodontic treatment. Moreover, despite the short-term follow-up, it also showed a reduction in the severity of the hypernasality sentences.

The competitive dynamics of strategic groups perform a major role in shaping the competitive background of industries. Strategic groups are sets of companies within an industry that follow related strategies or have comparable characteristics, such as product offerings, target markets, or geographic scale. Understanding these dynamics is central for firms to spot opportunities and cope with challenges effectively. This paper reviews the literature on the competitive dynamics of strategic groups. It analyses the theoretical underpinnings of competitive dynamics of strategic groups and discusses the central dimensions of the concept, underscoring the importance of competitive dynamics for strategic groups. Our aim is to sum up these perspectives while providing a clear and integrated overview through a systematic literature review. Such systematic literature review was performed using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) method. PRISMA is a framework with evidence-based data designed to help authors carry out a systematic literature review. This systematic literature review sought to consolidate knowledge on this topic. A discussion on the theme is carried out, an ensuing conclusion came up and, finally, avenues for further research are recommended.

IntroductionThe aims of this study were to compare several countermovement jump (CMJ) kinetic variables between professional (PRO) and semi-professional (SEMI-PRO) futsal players and examine the differences amongst playing positions.MethodsCMJ performance from 56 male futsal players (25.2 ± 4.8 years; weight: 74.4 ± 6.4 kg) was analysed. Players were separated into PRO (n = 29; 27.0 ± 4.4 years; 75.4 ± 6.0 kg) and SEMI-PRO (n = 27; 22.7 ± 4.3 years; 73.1 ± 6.8 kg), and according to playing position: defenders (n = 16; 25.4 ± 3.7 years; 75.2 ± 6.0 kg), wingers (n = 26; 23.5 ± 4.5 years; 72.0 ± 6.9 kg), and pivots (n = 14; 28.0 ± 5.6 years; 77.8 ± 4.3 kg). Linear mixed models and effect sizes were used for the analyses based on the mean of two jumps for each variable.ResultsPRO players presented a deeper center of mass (COM) displacement (p = 0.002, ES = 0.83), greater eccentric (Ecc) absolute (p = 0.019, ES = 0.61) and relative peak power (p = 0.046, ES = 0.52), and achieved greater Ecc peak velocities (p = 0.004, ES = 0.76) when compared to SEMI-PRO. Non-significant and trivial-to-small differences were observed in all the other CMJ variables according to the competitive level and playing position.DiscussionEcc capabilities (i.e., deeper COM displacement, greater Ecc absolute and relative peak power, and peak velocity) during vertical jump seem to differentiate PRO and SEMI-PRO players. However, CMJ variables do not discriminate amongst playing positions in futsal players.

The aim of this study was to develop and validate regression models to predict the chemical composition and ruminal degradation parameters of corn silage by near-infrared spectroscopy (NIR). Ninety-four samples were used to develop and validate the models to predict corn silage composition. A subset of 23 samples was used to develop and validate models to predict ruminal degradation parameters of corn silage. Wet chemistry methods were used to determine the composition values and ruminal degradation parameters of the corn silage samples. The dried and ground samples had their NIR spectra scanned using a poliSPECNIR 900-1700 model NIR sprectrophotometer (ITPhotonics S.r.l, Breganze, IT.). The models were developed using regression by partial least squares (PLS), and the ordered predictor selection (OPS) method was used. In general, the regression models obtained to predict the corn silage composition (P>0.05), except the model for organic matter (OM), adequately estimated the studied properties. It was not possible to develop prediction models for the potentially degradable fraction in the rumen of OM and crude protein and the degradation rate of OM. The regression models that could be obtained to predict the ruminal degradation parameters showed correlation coefficient of calibration between 0.530 and 0.985. The regression models developed to predict CS composition accurately estimated the CS composition, except the model for OM. The NIR has potential to be used by nutritionists as a rapid prediction tool for ruminal degradation parameters in the field.

O foco principal deste trabalho é explorar a origem do conceito de polinômios de Gauss ou coeficiente q-binomial, relacionando suas propriedades com o coeficiente binomial. Essa estrutura pode ser usada em uma infinidade de interpretações combinatórias estudadas no Ensino Médio e início do Ensino Fundamental II. Os coeficientes binomiais aparecem naturalmente como multiplicadores na expansão de , onde e são números reais. Esses coeficientes possuem uma estreita relação com as combinações simples e são amplamente utilizados em combinatória. Eles possuem uma riqueza de identidades que podem ser demonstradas tanto por métodos algébricos quanto combinatórios. A ideia principal deste trabalho é apresentar uma diversidade de propriedades inerentes ao conceito de polinômios de Gauss e, ao mesmo tempo, calcular o limite quando tende a . Observa-se que o resultado gera identidades provenientes do coeficiente binomial. Essa função polinomial é inicialmente definida por meio de uma função racional, mas ao longo do trabalho, observa-se que ela pode ser representada como uma função polinomial na variável , com . Ao expandir essa função polinomial, obtemos coeficientes que carregam informações de problemas de natureza combinatória. Essa característica interessante permite ao docente estabelecer uma conexão entre conceitos algébricos e combinatórios. Uma outra propriedade interessante inerente ao coeficiente binomial é a relação estendida de Stifel para o polinômio de Gauss que permite a construção de um triângulo aritmético, explorando a natureza geométrica para resolver problemas combinatórios e algébricos. No entanto, o objetivo é descrever a origem do conceito e apresentar uma maneira diferente de introduzir uma classe de polinômios, explorando as operações algébricas entre eles e unindo, de maneira elegante, a Álgebra com a Análise Combinatória.

Abstract Objective: To describe the time trends and socio-economic inequalities in infant and young child feeding practices in accordance with the Brazilian deprivation index (BDI). Design: This time-series study analysed the prevalence of multiple breast-feeding and complementary feeding indicators based on data from the Brazilian Food and Nutrition Surveillance System, 2008–2019. Prais–Winsten regression models were used to analyse time trends. Annual percent change (APC) and 95 % CI were calculated. Setting: Primary health care services, Brazil. Participants: Totally, 911 735 Brazilian children under 2 years old. Results: Breast-feeding and complementary feeding practices differed between the extreme BDI quintiles. Overall, the results were more favourable in the municipalities with less deprivation (Q1). Improvements in some complementary feeding indicators were observed over time and evidenced such disparities: minimum dietary diversity (Q1: Δ 47·8–52·2 %, APC + 1·44, P = 0·006), minimum acceptable diet (Q1: Δ 34·5–40·5 %, APC + 5·17, P = 0·004) and consumption of meat and/or eggs (Q1: Δ 59·7–80·3 %, APC + 6·26, P < 0·001; and Q5: Δ 65·7–70·7 %, APC + 2·20, P = 0·041). Stable trends in exclusive breast-feeding and decreasing trends in the consumption of sweetened drinks and ultra-processed foods were also observed regardless the level of the deprivation. Conclusions: Improvements in some complementary food indicators were observed over time. However, the improvements were not equally distributed among the BDI quintiles, with children from the municipalities with less deprivation benefiting the most.

Fuzzy marketing considers the degree to which a customer belongs to specific segments and subsequently allows them to be targeted with messages that engage them emotionally. To better understand the application and importance of fuzzy logic in marketing strategy, we developed a systematic literature review with bibliometric analysis to examine a sample of 96 studies from the SCOPUS database to identify research activity on this topic until December 2022. It was possible to create a connection between these concepts, marketing and fuzzy logic, to increase the efforts of marketing professionals. For instance, the results show that adopting approaches such as fuzzy marketing or the fuzzy marketing mix model enhances the company’s capability to build stronger customer relationships, enhance profitability, and improve marketing performance.

Despite the recognized potential of nanoparticles, only a few formulations have progressed to clinical trials, and an even smaller number have been approved by the regulatory authorities and marketed. Virus-like particles (VLPs) have emerged as promising alternatives to conventional nanoparticles due to their safety, biocompatibility, immunogenicity, structural stability, scalability, and versatility. Furthermore, VLPs can be surface-functionalized with small molecules to improve circulation half-life and target specificity. Through the functionalization and coating of VLPs, it is possible to optimize the response properties to a given stimulus, such as heat, pH, an alternating magnetic field, or even enzymes. Surface functionalization can also modulate other properties, such as biocompatibility, stability, and specificity, deeming VLPs as potential vaccine candidates or delivery systems. This review aims to address the different types of surface functionalization of VLPs, highlighting the more recent cutting-edge technologies that have been explored for the design of tailored VLPs, their importance, and their consequent applicability in the medical field.

The management and improvement of yam productivity are associated with a good supply of essential nutrients for the growth and development of the crop that has economic viability. This research aimed to evaluate the economic feasibility of foliar fertilization with Zintrac® in two yam agricultural seasons (2022/2023 and 2023/2024). Therefore, two experiments were conducted at the Rafael Fernandes Experimental Farm, Mossoró, RN, Brazil. The experimental design was in a Latin square design with five treatments of doses of Zintrac® (0, 1, 2, 3, and 4 L ha−1) and five replications. Among the production costs of yams, labor and seed acquisition were the most significant. The highest profitability index was achieved with the dose of 1L Zintrac® ha−1 in the first season and second season, which corresponded to 78.97 and 57.86%. For the first season, increments were observed in all treatments that received zinc doses with increases of 48.70, 31.22, 14.30, and 15.93% for 1, 2, 3, and 4 L of Zintrac® ha−1 compared to the dose of 0 L ha−1. On the other hand, in the second season, there was an increase only in the dose of 1 L ha−1 of Zintrac®, which corresponded to 51.3% in the net yield (ha−1) of the dose of 0 L ha−1. Therefore, foliar zinc oxide fertilization was economically viable for the yam crop, obtaining higher economic indices at the dose of 1 L ha−1. The highest cost for growing yams is using a dose of 4 L ha−1 of Zintrac®, totaling USD 6977.59 (first season) and USD 6868.33 (second season)

Abstract SARS-CoV-2 vaccines are useful tools to combat the Coronavirus Disease 2019 (COVID-19) pandemic, but vaccine reluctance threatens these vaccines’ effectiveness. To address COVID-19 vaccine reluctance and ensure equitable distribution, understanding the extent of and factors associated with vaccine acceptance and uptake is critical. We report the results of a large nationwide study in the US conducted December 2020-May 2021 of 36,711 users from COVID-19-focused smartphone-based app How We Feel on their willingness to receive a COVID-19 vaccine. We identified sociodemographic and behavioral factors that were associated with COVID-19 vaccine acceptance and uptake, and we found several vulnerable groups at increased risk of COVID-19 burden, morbidity, and mortality were more likely to be reluctant to accept a vaccine and had lower rates of vaccination. Our findings highlight specific populations in which targeted efforts to develop education and outreach programs are needed to overcome poor vaccine acceptance and improve equitable access, diversity, and inclusion in the national response to COVID-19.