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Author(s): Michael J. Zvolensky [sup.1] [sup.2] [sup.3] , Andrew H. Rogers [sup.1] , Justin M. Shepherd [sup.1] , Anka A. Vujanovic [sup.1] , Jafar Bakhshaie [sup.1] Author Affiliations: (1) grid.266436.3, [...], It is unclear if anxiety sensitivity may serve as mechanism underlying the relation between posttraumatic stress symptom severity and opioid misuse and dependence among trauma-exposed persons with chronic pain. Therefore, the current study evaluated the explanatory role of anxiety sensitivity in the relations between posttraumatic stress symptom severity and opioid misuse and dependence. Participants included 294 trauma-exposed adults with chronic pain (71.4% female, M.sub.age = 37.79 years, SD = 10.85, M.sub.pain rating = 7.32/10) that reported current moderate to severe chronic pain and prescription opioid use. Participants were recruited via an online national survey in the United States of America. There were statistically significant indirect effects of posttraumatic stress symptom severity via anxiety sensitivity in relation to opioid misuse and dependence. The indirect effects of the reverse models for opioid misuse and dependence also were significant and suggest the potential for bi-directional relations; however, the magnitude of the effect was smaller in the tests of specificity than in the original models. The present findings provide initial empirical evidence that greater posttraumatic stress symptom severity is related to anxiety sensitivity, which in turn, is associated with increased opioid misuse and dependence among trauma-exposed individuals with chronic pain.

A drug can improve the effectiveness of a behavioural treatment for fearful memories, at least in mice. Long-term memories of traumatic events, which can result in anxiety disorders, are difficult [...]