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Your search keyword '"Transplatinum(II) complexes"' showing total 2 results
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2 results on '"Transplatinum(II) complexes"'

1. New trans dichloro (triphenylphosphine)platinum(II) complexes containing N-(butyl),N-(arylmethyl)amino ligands: Synthesis, cytotoxicity and mechanism of action.

Author

Dalla Via, Lisa, García-Argáez, Aída Nelly, Agostinelli, Enzo, Belli Dell’Amico, Daniela, Labella, Luca, and Samaritani, Simona

Subjects
*TRIPHENYLPHOSPHINE, *PLATINUM, *BENZYLIC group, *LIGANDS (Biochemistry), *CANCER cells
Abstract

Some new platinum(II) complexes have been prepared, of general formula trans -[PtCl 2 (PPh 3 ){NH(Bu)CH 2 Ar}], where the dimension of the Ar residue in the secondary amines has been varied from small phenyl to large pyrenyl group. The obtained complexes, tested in vitro towards a panel of human tumor cell lines showed an interesting antiproliferative effect on both cisplatin-sensitive and -resistant cells. For the most cytotoxic derivative 2a the investigation on the mechanism of action highlighted the ability to induce apoptosis on resistant cells and interestingly, to inhibit the catalytic activity of topoisomerase II. [ABSTRACT FROM AUTHOR]

Published
2016
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2. New trans dichloro (triphenylphosphine)platinum(II) complexes containing N-(butyl),N-(arylmethyl)amino ligands: Synthesis, cytotoxicity and mechanism of action

Author

Luca Labella, Daniela Belli Dell'Amico, Simona Samaritani, Lisa Dalla Via, Aída Nelly García-Argáez, and Enzo Agostinelli

Subjects
Magnetic Resonance Spectroscopy, Organoplatinum Compounds, Stereochemistry, Cell Survival, Clinical Biochemistry, Pharmaceutical Science, chemistry.chemical_element, Apoptosis, Antiproliferative activity, 010402 general chemistry, Ligands, 01 natural sciences, Biochemistry, Catalysis, Residue (chemistry), chemistry.chemical_compound, Structure-Activity Relationship, Cell Line, Tumor, Drug Discovery, medicine, Humans, DNA topoisomerases, Triphenylphosphine, Amines, Cytotoxicity, Molecular Biology, Cell Proliferation, Transplatinum(II) complexes, Molecular Medicine, Organic Chemistry, Drug Discovery3003 Pharmaceutical Science, 3003, biology, 010405 organic chemistry, Topoisomerase, Cell Cycle, Flow Cytometry, In vitro, 0104 chemical sciences, chemistry, Mechanism of action, biology.protein, medicine.symptom, Platinum, HeLa Cells
Abstract

Some new platinum(II) complexes have been prepared, of general formula trans-[PtCl2(PPh3){NH(Bu)CH2Ar}], where the dimension of the Ar residue in the secondary amines has been varied from small phenyl to large pyrenyl group. The obtained complexes, tested in vitro towards a panel of human tumor cell lines showed an interesting antiproliferative effect on both cisplatin-sensitive and -resistant cells. For the most cytotoxic derivative 2a the investigation on the mechanism of action highlighted the ability to induce apoptosis on resistant cells and interestingly, to inhibit the catalytic activity of topoisomerase II.

Published
2016

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