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Copyright of Pamukkale Medical Journal is the property of Pamukkale Journal of Medicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Intensive Care Nursing is the property of Journal of Intensive Care Nursing and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

This article explores the role of macrophages in graft rejection after organ transplantation. Macrophages are cells in the immune system that recognize antigens and are associated with an increased incidence of graft rejection. The article discusses potential macrophage-targeted therapeutic strategies to improve graft survival and reviews the literature on the role of macrophages in organ transplantation. It also discusses the role of macrophages in acute and chronic rejection, as well as various macrophage-targeted therapies. The authors emphasize the need for further research to understand macrophages' roles in graft survival and the importance of studying different macrophage phenotypes for developing targeted therapy strategies. [Extracted from the article]

Copyright of Pamukkale Medical Journal is the property of Pamukkale Journal of Medicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: Hepatocellular cancer (HCC) is the most common malignancy of the hepatobiliary system. There are significant differences in the global spread of HCC. It is the major cause of death in patients with cirrhosis. Its molecular pathogenesis is highly complex and heterogeneous. Major risk factors for the development of HCC are chronic hepatitis B virus (HBV) infection, chronic hepatitis C virus (HCV) infection and alcoholrelated liver cirrhosis. Hepatocellular cancer is rarely seen in the first 4 decades of life, except in communities where HBV infection is hyperendemic. Methods: The study was conducted by retrospectively scanning the files of 204 patients diagnosed with HCC who applied to Organ Transplantation Center between 21.09.2014 and 13.04.2019. Patients were transplanted liver by being classified according to Milan criteria, San Francisco [University of California San Francisco (UCSF)] criteria, and Barcelona Clinic Liver Cancer (BCLC) criteria. Results: The median age of the patients was 58.03 (range 31 to 72). 170 of the patients were men and 34 of them were female. Liver transplantation (LT) was performed from cadaveric donors to 31 patients and from living donors to 173 patients. There is a significant relationship between the life span of the patients and their gender. Female patients have a longer life expectancy [t (202) = 2.963, p =0.003]. A significant relationship was found between life expectancy and surgical classification [F (3) = 3.008, (p =0.031)]. Conclusions: In patients diagnosed with HCC and undergoing LT; the gender being female and the classification method before transplantation affect life expectancy. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Midwifery & Health Sciences is the property of Ataturk University Coordinatorship of Scientific Journals and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Yeni Üroloji Dergisi is the property of Ali Ihsan Tasci and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Osmangazi Journal of Medicine / Osmangazi Tip Dergisi is the property of Eskisehir Osmangazi University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The antibodies interact with the “Human Leukocyte Antigen (HLA) antigens” at specific epitopes. “Epitopes” are present on a single HLA or shared by multiple antigens. In this study, we aim to determine the frequency of prevalent epitopes common in the Turkish population.

Copyright of Gümüshane Üniversitesi Saglik Bilimleri Dergisi is the property of Gumushane University, Faculty of Health Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Yeni Üroloji Dergisi is the property of Ali Ihsan Tasci and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Amaç: Bu çalışmanın amacı kadaverik karaciğer transplantasyonu yapılmış hepatosellüler karsinomalı hastalarda downstaging ve bridging tedavilerinin transplantasyon sonrası sağ kalım süreleri üzerine etkilerini araştırmaktır.Gereç ve Yöntem: Çalışmamıza hepatosellüler karsinoma tanısı almış ve kadaverik karaciğer transplantasyonu yapılmış 33 hasta dahil edilmiştir. Bu hastalar downstaging, bridging ve kontrol olmak üzere 3 gruba ayrılmıştır. Bridging ve downstaging gruplarına transplantasyon öncesi transarteriyal kemo-embolizasyon, transarteriyal radyo-embolizasyon, radyofrekans ablasyon veya mikrodalga ablasyon tedavileri uygulanırken kontrol grubuna herhangi bir tedavi uygulanmadı. Transplantasyon sonrası sağ kalım süreleri hesaplanırken Kaplan-Meier yaşam analizi kullanıldı.Bulgular: Ortalama takip süresi 37,5±32,1 ay olarak hesaplandı. Genel sağ kalım oranı %48,5 idi. En yüksek sağ kalım oranı bridging grubunda (%54,5), daha sonra kontrol grubunda (%50,0) ve en düşük olarak (%41,7) downstaging grubunda olduğu tespit edildi. Her ne kadar gruplar arasında farklılıklar olsa da istatistiksel olarak anlamlı sonuçlar elde edilemedi.Sonuç: Bu çalışma ile bridging ve downstaging yöntemlerinin transplantasyon yapılacak hepatosellüler karsinomalı hastaları Milan Kriterleri içinde tutmaya yarayan etkili staratejiler olduğu, downstaging yöntemi uygulanan bazı hastalarda sağ kalım sürelerinin ortalamanın üstüne çıktığı sonucu elde edilmiştir.

Objective: Although inhibition of the complement system at different steps is a promising therapy modality in patients with paroxysmal nocturnal hemoglobinuria (PNH), allogeneic hematopoietic stem cell transplantation (HCT) is still the only curative therapy, especially for patients with intractable hemolysis or bone marrow failure. The aim of this study is to evaluate the outcomes of allogeneic HCT in PNH patients with aplastic anemia (PNH-AA) or without. Materials and Methods: Thirty-five PNH/PNH-AA patients who were treated with allogeneic HCT in 10 transplantation centers in Turkey were retrospectively analyzed. Results: Sixteen (45.7%) and 19 (54.3%) patients were diagnosed with classical PNH and PNH-AA, respectively. The median age of the patients was 32 (18-51) years. The 2-year overall survival (OS) rate and rate of graft-versus-host disease-free, failure-free survival (GFFS) was 81.2% and 78.1%, respectively. The 2-year OS in cases of classical PNH and PNH-AA was 81.3% and 79.9%, respectively (p=0.87), and 2-year GFFS in cases of PNH and PNH-AA was 79% and 76% (p=0.977), without statistical significance. The OS and GFFS rates also did not differ between transplantations with matched sibling donors (MSDs) and matched unrelated donors (MUDs). Conclusion: Allogeneic HCT with MSDs or MUDs is a good option for selected patients with classical PNH and PNH-AA. In particular, patients with debilitating and refractory hemolysis and patients with bone marrow failure might form an excellent group of candidates for allogeneic HCT. [ABSTRACT FROM AUTHOR]

Copyright of Pamukkale Medical Journal is the property of Pamukkale Journal of Medicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Giriş: Renal transplantasyon son dönem böbrek yetmezliği hastalarının yaşam kalitesinde olumlu değişiklikler sağlayan en seçkin tedavidir. İmmünosüpresyona bağlı enfeksiyöz komplikasyonlar nakil sonrası artmış mortalite ve morbiditenin en önemli nedenlerindendir. Bu olguda renal transplantasyondan sonra geç dönemde meydana gelen birden fazla patojenin etken olduğu kolit sunuldu. Olgu: Hipertansiyona bağlı kronik böbrek yetmezliği nedeni ile 2019 yılında babasından renal transplantasyon yapılan 39 yaşında erkek hasta bir aydır devam eden ishal, yüksek ateş ve kilo kaybı ile nefroloji polikliniğine başvurmuş. Clostridioides difficile toxin-b tetkiki pozitifliği ile oral metronidazol tedavisi başlanmış. İshalinde gerileme olmaması nedeni ile nefroloji servisine yatırılan ve tarafımıza konsülte edilen hastanın fizik muayenesinde sağ alt kadranda hassasiyet mevcuttu, diğer muayene bulguları doğaldı. Oral vankomisin tedavisi başlandı. İshalde gerileme olmaması nedeni ile gönderilen dışkı etken panelinde Norovirus PCR pozitif, kan CMV PCR <34,5 IU/ml olarak sonuçlandı. Yüksek ateş ve akut faz reaktan artışı olan hastanın tedavisine meropenem ve tigesiklin eklendi. Abdomen bilgisayarlı tomografisinde çekum duvarında ve distal ileal bölgede 14 cm segmentte diffüz asimetrik duvar kalınlaşması izlendi. Kolonoskopisinde çıkan kolondan çekuma kadar uzanan üzeri eksudalı düzensiz sınırlı ülsere frajil kitlesel lezyon izlendi (Şekil 1). Gastroenterolojinin ön planda malignite düşündüğü hastanın doku örneklerinden sadece patoloji gönderilmiş olup patolojisi çıkan kolonda nekrotizan granülomatöz, diğer alanlarda nekrotizan olmayan granülomların olması nedeni ile ayırıcı tanıda öncelikle tüberküloz, yersinia gibi enfeksiyöz nedenler düşünülmelidir şeklinde raporlandı. EZN negatif boyandı. Tedavisine yersinia kolitine yönelik siprofloksasin eklendi. Tüberküloz açısından doku mikobakteriyoloji örnekleri gönderilmesi önerildi. Gastroenteroloji tarafından perforasyon riski nedeni ile kolonoskopi ileri tarihe ertelenedi. Oral vankomisin, meropenem, tigesiklin, siprofloksasin altında ishali devam eden hastanın tedavisine gastrointestinal tüberküloz ön tanısıyla izoniazid, rifampisin, etambutol ve pirazinamid eklendi. Antitüberküloz tedavi altında kliniği düzelen hastanın diğer antibiyoterapileri 14 günde kesildi. Antitüberküloz tedavisinin 20. gününde yüksek ateş ve ishali tekrarlayan hastanın kontrol kolonoskopisinde hepatik fleksuradan çekuma kadar uzanan düzensiz sınırlı frajil polipoid lezyonlar önceki incelemeyle kıyaslandığında boyutlarında regresyon ve terminal ileumda ülsere eksudalı alanlar izlendi. Kan CMV PCR 7,53x102 IU/ml ve doku CMV PCR 9,58x103 IU/ml olan hastanın tedavisine gansiklovir eklendi. Antitüberküloz ve gansiklovir ile klinik ve laboratuvar yanıt alındı. Sonuç: İmmünsüpresif hastalarda fırsatçı enfeksiyonlar açısından dikkatli olunmalıdır. Gerekli durumlarda invaziv tetkikler mutlaka yapılmalıdır. [ABSTRACT FROM AUTHOR]

Objective: Kidney transplantation is the best treatment option for patients with end-stage renal disease. However, renal transplant recipients have been shown to have a higher risk of cancer than the general population. This has been attributed to malignancies associated with immunosuppression in these patients. In our study, we aimed to investigate the incidence of post-transplant malignancy, duration of development and risk factors in kidney transplant recipients. Method: 1029 patients who underwent kidney transplantation in our organ transplant clinic between January 2006 and December 2018 were analyzed retrospectively through their demographic data, immunosuppressive protocols, post-transplant cancer types, and cancer onset files. Results: Cancer developed in a total of 21 recipients (2%). The donor of 89.5% of the cases was alive. There was a history of smoking in 64.3% of the cases, and a family history of cancer in 45.5%. The most common type of cancer was skin cancer (n: 4). Basal cell Ca in 2 cases with skin cancer, Kaposi sarcoma in 1 case, and Merkel Cell Ca in 1 case (Table 2). Two of our patients with lung cancer had a history of smoking. The family history of our 2 cases with gastric cancer was positive. However, no statistically significant difference was found between family history and smoking and cancer incidence (p=0.576) Conclusions: As transplant recipients continue to live longer with improved outcomes, cancer will increase as a cause of morbidity and mortality in this population. More research is needed to understand whether tumors arising in this population are affected by the patient's immunosuppression. [ABSTRACT FROM AUTHOR]

Physical, emotional and economic aspects of transplantation are an important life experience for the patient and the family. Good organizational success in transplantation, surgery preparation and post-operative care is extremely important as well as biopsychosocial care and rehabilitation. This study describes the post-transplant experiences of patients who underwent kidney transplantation. In this study qualitative exploratory research design was used and collecting comprehensive information about the post-transplant psychosocial experiences of kidney transplant patients was aimed at. The sample of the study was consisted of 15 participants over the age of 18 who had organ transplantation at Mediterranean University Hospital Institute of Transplantation. Data were analyzed using content analysis for which nine themes were identified as challenges of life, changes in mood, changes in self-perception, the meaning of organ transplantation for the individual, interpersonal relationships, increased productivity, coping, perception of the organ, feelings towards the donor. In this study, detailed data about biopsychosocial lives, organ perception, donor perception and coping methods were obtained after kidney transplantation. These results can make a significant contribution to nursing care in the transplantation process. [ABSTRACT FROM AUTHOR]

Aim: Patients with chronic kidney disease (CKD) are at an increased risk for depression. In the present study, we aimed to compare the frequency and severity of depression and its' association with demographical and laboratory parameters between stage 4 and 5 CKD patients with and without kidney transplantation. Methods: The study included stage 4 and stage 5 CKD patients not on dialysis. The patients were separated into two groups. Group 1 was composed of patients with renal transplantation and group 2 was composed of patients without renal transplantation. The prevalence of depression was evaluated using the Beck Depression Inventory. Results: Forty-nine patients were in group 1 and 52 patients in group 2. The mean depression score in group 1 was statistically significantly higher than in group 2 (16±15 vs 13.5±10; p=0.031). We found that depression score was correlated with parathormone levels (p=0.023) and serum ferritin levels (p=0.019). In multivariate linear regression analysis, depression scores were independently associated with parathormone [Exp (B): 0.997 (confidence interval (CI): 0.995-1.0); p=0.023] and ferritin [Exp (B): 0.996 (CI: 0.994-0.998); p=0.01]. Conclusion: Higher prevalence of depression in patients with CKD who received renal transplantation is a significant finding. Routine psychiatric evaluation should become a part of follow-up and treatment in both groups. [ABSTRACT FROM AUTHOR]

Copyright of Yeni Üroloji Dergisi is the property of Ali Ihsan Tasci and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: The success rates of renal transplantation in pediatric age groups increased rapidly with the improvement of surgical technique, development of immunosuppressive drugs and the establishment of follow-up protocols specific to the pediatric age group and achieved the success rates of adult transplantation. In this study, we retrospectively analyzed the results of pediatric renal transplants performed in our center in 9 years. Method: Between January 2010 and December 2018, 41 pediatric renal transplants were performed in our center. In our study, demographic data of donors and recipients, immunosuppressive treatment protocols applied to the recipients, post-transplant complications and renal functions of these donors were evaluated. Results: Mean age of the recipients was 13.44 ± 3.72 and 48.8% of the recipients were female. The mean follow-up period was 46.90 ± 30.04 months. During the follow-up period, no complications due to surgery developed. One patient (2.4%) had urologic complications requiring endoscopic intervention. One patient (2.4%) had sepsis-related mortality, one patient (2.4%) had recurrence of primary disease, and three patients (7.2%) had graft loss due to medical noncompliance. The mean age was 43.15 ± 9.28 years and 53.7% of the donors were female . During the followup, wound-related complications were observed in two patients (4.8%). There was no change in renal function detected. Conclusions: The results of our study show that pediatric renal transplantation was performed safely and successfully in our center when compared with the literature data published from the studies conducted in centers with high number of patients and systematic reviews. [ABSTRACT FROM AUTHOR]

Introduction: The possibility of brain death (BD) among patients with a Glasgow Coma scale <7 must be considered by physicians who work in intensive care units. Deceased organ transplantation can be lifesaving so every BD patient should be seen as a potential donor. The aim of this study was to describe the causes of BD, rate of organ donation and to investigate the effect of diagnosis time on donation rates in our hospital over a 9-year period. Methods: After obtaining Institutional Ethics Committee approval, we conducted a retrospective review of patients who had sustained BD in our hospital between January 1, 2004 and January 1, 2013. Patients' age, methods used to diagnose BD, duration of survival after diagnosis, whether patients' family members gave consent to organ donation, and organ donation rates were reviewed. Results: Sixty patients were declared BD, of whom 21 (35%) were female and 39 (65%) were male. Their mean age was 28 years. Only 6 (10%) patients' families gave consent for donation. The most common cause of BD was traumatic brain injury (n=37, 62%). Internal carotid artery doppler ultrasonography was performed in 36 (60%) patients; cerebral angiography was performed in 14 (23%) patients; and electroencephalography was performed in two patients. The mean time from hospital admission to diagnosis of BD was 5.16±3.06 days overall; 5.5±0.4 days among non-donors; and 2.0±0.4 days among donors. The mean time from diagnosis of BD to death in non-donors was 2.4±0.3 days. In donors, the mean time from diagnosis of BD to harvesting of the patient's organs was 1.08±0.2 days. Conclusion: In our hospital, the rate of organ donation after BD is low. It is found that the time to confirm the diagnosis of BD was significantly shorter in donors than non-donors. It is believed that early diagnosis of BD is associated with an increased rate of family approval for organ donation. [ABSTRACT FROM AUTHOR]

Copyright of Cukurova Medical Journal / Çukurova Üniversitesi Tip Fakültesi Dergisi is the property of Cukurova University, Faculty of Medicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: The study was conducted to determine healthy life style behaviors and life satisfaction of patients with renal transplant. Material-Method: The population of the descriptive study consisted of patients who presented to the outpatient clinic of Ege University Organ Transplantation and Research Center between 23 March and 10 July 2015 after kidney transplantation. The study sample included 80 patients with kidney transplantation, over 18 years of age and who agreed to participate in the study. Sociodemographic questionnaire consisting of 13 questions developed in accordance with the literature, Healthy Lifestyle Behavior Scale and Life Satisfaction Scale were used to collect the data. The SPSS package program was used to evaluate the data. After obtaining approval from the Scientific Ethics Committee of Ege University Faculty of Nursing for the research, written permission was obtained from the institution to be investigated. Results: The mean age of the patients participating in the study was 36.44±10.24 years. It was determined that 52.5% of the patients were male, 42.5% were high school graduates, 72.5% were married, 27.4% were workers, 50.0% lived in the province and 43.8% had kidney disease for 6-10 years. The mean score of the Healthy Lifestyle Behavior Scale of the participating patients was 126.32±12.20 and the mean score of the Life Satisfaction Scale was 11.60±2.24. Conclusions: According to the results obtained from the study, the healthy lifestyle behaviors and life satisfaction of the patients were found to be moderate. [ABSTRACT FROM AUTHOR]

Objective: The aim of this study was to investigate the attitudes of patient relatives about organ donation for patients with brain death diagnosis and to identify the cause of negative attitudes related to donation. Methods: A retrospective examination was made of the archived records of patients with brain death (BD) diagnosis from September 2007 to August 2018 in Anesthesia Reanimation Intensive Care Unit. Demographic factors of the cases with BD such as age, gender, and admission diagnosis were recorded. The patient families were then contacted by telephone and organ donation acceptance or rejection was assessed in terms of reasons. Results: A total of 86 cases with brain death diagnosis were identified. When cases were assessed in terms of admission diagnoses, post-CPR hypoxic brain was the most common diagnosis (30.2%). The organ donation rate was identified as 12.8% (n=11). The mean age of patients was 31.09±20.98 years in those who donated organs, and 35.62±21.45 years in those whose families rejected donation (p=0.614). When the factors causing brain death of patients with organ donation were assessed, 54.4% died due to traumatic reasons. The two most important factors identified in the study for families rejecting organ donation were religious beliefs (41.3%) and beliefs about not disrupting the integrity of the body after death (37.3%). The most important factor for acceptance was the wish to help other people (91%). Conclusion: In our study, religious beliefs were found as the main reason for rejection of organ donation. To be able to increase cadaver-sourced donation rates, there is a need for society to be informed by religious leaders, family interviews should be held with an experienced and trained organ donation co-ordinator and families should definitely be fully informed about the sensitivity shown to bodily integrity during the organ donation procedure and surgical procedures. [ABSTRACT FROM AUTHOR]

Copyright of ANKEM Antibiyotik & Kemoterapi Dergisi is the property of ANKEM Antibiyotik & Kemoterapi Dergisi and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Purpose: The aim of this study was to compare the efficacy and early-late results of subtotal parathyroidectomy and total parathyroidectomy/auto transplantation without cryopreservation conducted on cases with secondary hyperparathyroidism (HPT). Materials and Methods: 68 patients with secondary HPT who had parathyroidectomy were analysed retrospectively. In group1 (n=47) subtotal parathyroidectomy, in group2 (n=21) total parathyroidectomy/auto transplantation without cryopreservation were performed in our clinic. Patients' demographic characteristics and clinical features were evaluated. Results: In group1 8 patients (14.9%), in group2 17 patients (76.2%) had concurrent thymectomies. The rates of persistant HPT in group1 and group2 were 14.9% (n=7), 4.8% (n=1) respectively. In group2 no recurrent HPT was seen, in group2 10.6% (n=5) of the patients had recurrent HPT. The reasons of persistent and recurrent HPT were ectopic or supernumerary glands in 69.2% (n=9) of the patients. Conclusion:. In patients with end stage renal failure and secondary HPT, bilateral cervical thymectomy concurrent with total parathyroidectomy/auto transplantation without cryopreservation can be applied as a safe and efficient surgical procedure. [ABSTRACT FROM AUTHOR]

Objective: The rate of steatosis is the parameter that should be assessed in steatohepatitis and donor liver biopsies before transplantation. The percentage of steatosis, evaluated as quantitative / semiquantitative, differs between observers and intra-observers. Various image analysis methods have been developed in order to reduce this difference. In our study, pathologists examined virtually created digitized images mimicking liver fat. The results' accuracy rates and differences in assessment, that would impact clinical management, were investigated. Methods: Nine pictures with white circles on a pink background, simulating steatosis, were prepared with the 'Kameram' program. The steatosis area was calculated by computer. These pictures were shared with the Istanbul Hepatopancreatobiliary pathology study group. Participants were asked to specify the percentage of steatosis for each image. The results were compared to computer values. Results: Nineteen pathologists participated in the evaluation. Fifteen of the pathologists indicated higher steatosis percentage than the computirised calculated values, either in all pictures or most of the pictures. Only 1 participant reported the same values with the computer. Difference between computer values and pathologists' values ranged from as high as 40% to as low as 20%. When the images were thought to represent the donor liver, only 3 pathologists succeeded in proper clinical management in all cases, while 11 of the pathologists had misdiagnosed clinical management in 1 case, 4 pathologists in 2 cases, 1 pathologist in 3 cases. When it was thought that the pictures represented the steatohepatitis evaluation, all pathologists correctly scored only 2 pictures and at least 2 pathologists gave high scores in 5 of the pictures. Inter-pathologist agreement was moderate to good with assessing steatohepatitis and donor liver (kappa values, respectively: 0.51 and 0.63). Conclusion: In our study, it is observed that pathologists generally evaluate the steatosis rate higher than real calculated values. This can affect the clinic, in both steatohepatitis scoring classification and graft management differently. Computer-aided automated programs, which are increasingly used in routine pathology to overcome the differences in pathologist evaluations and clinical manifestations, also can have a role in the detection of liver steatosis ratio. [ABSTRACT FROM AUTHOR]

Copyright of Turkish Journal of Obstetrics & Gynecology is the property of Galenos Yayinevi Tic. LTD. STI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Hematopoietic stem cell transplantation is a promising curative therapy for many combined primary immunodeficiencies and phagocytic disorders. We retrospectively reviewed pediatric cases of patients diagnosed with primary immunodeficiencies and scheduled for hematopoietic stem cell transplantation. We identified 22 patients (median age, 6 months; age range, 1 month to 10 years) with various diagnoses who received hematopoietic stem cell transplantation. The patient diagnoses included severe combined immunodeficiency (n=11), Chediak-Higashi syndrome (n=2), leukocyte adhesion deficiency (n=2), MHC class 2 deficiency (n=2), chronic granulomatous syndrome (n=2), hemophagocytic lymphohistiocytosis (n=1), Wiskott-Aldrich syndrome (n=1), and Omenn syndrome (n=1). Of the 22 patients, 7 received human leukocyte antigen-matched related hematopoietic stem cell transplantation, 12 received haploidentical hematopoietic stem cell transplantation, and 2 received matched unrelated hematopoietic stem cell transplantation. The results showed that 5 patients had graft failure. Fourteen patients survived, yielding an overall survival rate of 67%. Screening newborn infants for primary immunodeficiency diseases may result in timely administration of hematopoietic stem cell transplantation. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Istanbul University Faculty of Dentistry / Istanbul Üniversitesi Dis Hekimligi Fakültesi Dergisi is the property of Istanbul University, Faculty of Dentistry and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The aim of this study was to investigate the protective effect of Viburnum opulus L. fruit extract against ischemia/reperfusion (I/R)-induced oxidative stress during the lung transplantation. For this purpose, 30 female rats were firstly randomized to form of donor and recipients. After then, the rats were divided into three groups named as control, I/R, and V. opulus + I/R. Experimental rats were subjected to lung transplantation with ischemia followed by 2 h of reperfusion. Transplantation-related lung injury was evaluated by multiple parameters. A significant decrease was observed in the enzyme activities of superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT), and the levels of glutathione and total antioxidant status (TAS), whereas the levels of malondialdehyde (MDA), total oxidant status (TOS), and protein carbonyl were significantly increased in lung tissue samples of I/R group in comparison to the control group. However, treatment with V. opulus fruit extract resulted in significant reduction of MDA and protein carbonyl levels and increment of the antioxidant system. In conclusion, V. opulus fruit extract showed protective effects against I/R-induced oxidative stress during lung transplantation probably by the radical scavenging and antioxidant activity. Therefore, this fruit extract can be efficient in the prevention of I/R-related lung toxicity. [ABSTRACT FROM AUTHOR]

Copyright of Turkiye Klinikleri Journal of Internal Medicine / Türkiye Klinikleri İç Hastalıkları Dergisi is the property of Turkiye Klinikleri and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)