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165 results on '"Transcription factors -- Analysis"'

1. White adipocytes in subcutaneous fat depots require KLF15 for maintenance in preclinical models

Author

Li, Liang and Feldman, Brian J.

Subjects
Adipose tissues -- Measurement -- Health aspects, Transcription factors -- Analysis, Diabetics -- Care and treatment, Health care industry, Care and treatment, Analysis, Measurement, Health aspects
Abstract

Healthy adipose tissue is essential for normal physiology. There are 2 broad types of adipose tissue depots: brown adipose tissue (BAT), which contains adipocytes poised to burn energy through thermogenesis, and white adipose tissue (WAT), which contains adipocytes that store lipids. However, within those types of adipose, adipocytes possess depot and cell- specific properties that have important implications. For example, the subcutaneous and visceral WAT confers divergent risk for metabolic disease. Further, within a depot, different adipocytes can have distinct properties; subcutaneous WAT can contain adipocytes with either white or brown-like (beige) adipocyte properties. However, the pathways that regulate and maintain this cell and depot-specificity are incompletely understood. Here, we found that the transcription factor KLF15 is required for maintaining white adipocyte properties selectively within the subcutaneous WAT. We revealed that deletion of Klf15 is sufficient to induce beige adipocyte properties and that KLF15's direct regulation of Adrbl is a critical molecular mechanism for this process. We uncovered that this activity is cell autonomous but has systemic implications in mouse models and is conserved in primary human adipose cells. Our results elucidate a pathway for depot-specific maintenance of white adipocyte properties that could enable the development of therapies for obesity and associated diseases., Introduction Adipocytes are the most prominent cell type in mature adipose tissue and, in addition to being involved in energy homeostasis, these cells receive and produce a variety of potent [...]

Published
2024
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3. Findings from Children's Hospital Philadelphia Yields New Data on Science (Skeletal Growth Is Enhanced By a Shared Role for Sox8 and Sox9 In Promoting Reserve Chondrocyte Commitment To Columnar Proliferation)

Subjects
Skin diseases -- Diagnosis -- Care and treatment -- Genetic aspects, Gene expression -- Analysis, Transcription factors -- Analysis, Genome-wide association studies -- Analysis, Health
Abstract

2024 MAY 25 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Researchers detail new data in Science. According to news reporting from Philadelphia, [...]

Published
2024

5. New Transcription Factors Findings from Institute of Molecular and Cellular Biology Published (Transcription factor DREF regulates expression of the microRNA gene * * bantam in Drosophila melanogaster* *)

Subjects
MicroRNA -- Analysis, Drosophila -- Identification and classification -- Control -- Genetic aspects, Transcription factors -- Analysis, DNA binding proteins -- Analysis, Health
Abstract

2024 MAY 4 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Current study results on transcription factors have been published. According to news [...]

Published
2024

6. Reports Summarize Hirschsprung Disease Study Results from Faculty of Medicine (Aberrant SOX10 and RET expressions in patients with Hirschsprung disease)

Subjects
Hirschsprung's disease -- Diagnosis -- Risk factors -- Development and progression, Transfection -- Analysis, Transcription factors -- Analysis, Health
Abstract

2024 APR 6 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Research findings on Hirschsprung disease are discussed in a new report. According [...]

Published
2024

7. Data on Life Science Described by Researchers at South China Agricultural University (Bola Promotes the Generation of Multicellular Behavior In S. Typhimurium By Regulating the C-di-gmp Pathway Genes Yeaj and Yhjh)

Subjects
Drug resistance in microorganisms -- Prevention, Salmonella enteritidis -- Diagnosis -- Care and treatment, Transcription factors -- Analysis, Health
Abstract

2024 FEB 10 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Data detailed on Life Science have been presented. According to news reporting [...]

Published
2024

8. Findings on Obesity, Fitness and Wellness Reported by Investigators at Department of Computer Sciences and Engineering [A New Efficient Quorum Planted (l, D) Motif Search On Chip-seq Dataset Using Segmentation To Filtration and Freezin

Subjects
Nucleotide sequencing -- Evaluation, DNA sequencing -- Evaluation, Transcription factors -- Analysis, Health
Abstract

2024 JAN 20 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Current study results on Obesity, Fitness and Wellness have been published. According [...]

Published
2024

9. Paeonol reduces IL-[beta] production by inhibiting the activation of nucleotide oligomerization domain-like receptor protein-3 inflammasome and nuclear factor-[kappa]B in macrophages

Author

Chen, Gang, Guo, Tingwang, and Yang, Lin

Subjects
Phenols -- Identification and classification -- Properties, Transcription factors -- Analysis, Interleukin-1 -- Analysis, Biological sciences
Abstract

Interleukin-1[beta], a key cytokine in gouty inflammation, is precisely regulated by the NLRP3 inflammasome and NF-[kappa]B. Our previous study demonstrated that paeonol suppressed IL-1[beta] production in rats with monosodium urate (MSU)-induced arthritis. Whether NLRP3 inflammasome or NF-[kappa]B is responsible for the anti-inflammatory effect of paeonol remains unclear. In this study, J774A.1 cells induced by lipopolysaccharide (LPS) plus MSU, was used to investigate the effect of paeonol on NLRP3 inflammasome activation, and J774A1 cells induced by LPS alone were used to investigate the effect of paeonol on NF-[kappa]B activation. In J774A1 cells induced by LPS plus MSU, paeonol decreased the levels of IL-1[beta] and caspase-1 and reduced the MSU-induced interaction of pro-caspase-1 and apoptosis-associated speck-like protein containing caspase recruitment domain (ASC), but did not affect the levels of pro-IL-1[beta] and pro-caspase-1. In J774A1 cells induced by LPS alone, paeonol reduced the levels of IL-1[beta], NLRP3, p-IKK, p-I[kappa]B[alpha], and p-p65, but did not affect ASC levels. Paeonol also promoted the content of I[kappa]B[alpha] and retained more p65 in the cytoplasm. Further-more, paeonol reduced the DNA-binding activity of p65 and lowered the levels of p-JNK, p-ERK, and p-p38. These results suggest that paeonol inhibits IL-1[beta] production by inhibiting the activation of NLRP3 inflammasome, NF-[kappa]B, and MAPK signaling pathways. Key words: paeonol, IL-1[beta], NLRP3 inflammasome, NF-[kappa]B, gout. L'interleukine-1[beta], une cytokine cle dans l'inflammation goutteuse, est precisement regulee par l'inflammasome NLRP3 et le NF-[kappa]B. Une etude precedente realisee par les auteurs a demontre que le paeonol supprime la production d'IL-1[beta] chez les rats atteints d'arthrite induite par l'urate monosodique (MSU). La question de savoir si l'inflammasome NLRP3 ou le NF-[kappa]B est responsable de l'effet anti-inflammatoire du paeonol n'est toujours pas resolue. Dans cette etude, les cellules J774A.1 traitees au LPS en presence de MSU ont ete utilisees pour etudier l'effet du paeonol sur l'activation de l'inflammasome NLRP3, et les cellules J774A.1 traitees au LPS seul ont ete utilisees pour etudier l'effet du paeonol sur l'activation du NF-[kappa]B. Dans les cellules J774A.1 activees par le LPS en presence de MSU, le paeonol diminuait les niveaux d'IL-1[beta] et de caspase-1, reduisait l'interaction de la pro-caspase-1 et de l'ASC induite par le MSU, mais n'affectait pas les niveaux de pro-IL-1[beta] et de pro-caspase-1. Dans les cellules J774A.1 activees par le LPS seul, le paeonol reduisait les niveaux d'IL-1[beta], NLRP3, p-IKK, p-I[kappa]B[alpha] et p-p65, mais n'affectait pas le niveau d'ASC. Le paeonol augmentait egalement le contenu en I[kappa]B[alpha] et retenait davantage de p65 dans le cytoplasme. De plus, le paeonol reduisait l'activite de liaison a l'ADN de p65 et diminuait les niveaux de p-JNK, p-ERK et p-p38. Ces resultats suggerent que le paeonol inhibe la production d'IL-1 [beta] par l'inhibition de l'activation de l'inflammasome NLRP3, de la voie de signalisation du NF-[kappa]B et de MAPK. [Traduit par la Redaction] Mots-cles: paeonol, IL-1[beta], NLRP3 inflammasome, NF-[kappa]B, goutte., Introduction The prevalence and incidence of gout have risen rapidly in the last century (Singh and Gaffo 2020). Even though gout can be managed, it is incapacitating and grievously painful [...]

Published
2022
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10. Study Results from Augusta University in the Area of Cardiology Published (Identification of the metabolic state of surviving cardiomyocytes in the human infarcted heart by spatial single-cell transcriptomics)

Subjects
Heart diseases -- Care and treatment -- Genetic aspects, Heart cells -- Health aspects, RNA -- Analysis, Transcription factors -- Analysis, Health
Abstract

2023 SEP 2 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- New study results on cardiology have been published. According to news originating [...]

Published
2023

11. Pennsylvania State University (Penn State) Researcher Updates Understanding of Amino Acids (Contribution of Circulating Host and Microbial Tryptophan Metabolites Toward Ah Receptor Activation)

Subjects
Microbiota (Symbiotic organisms) -- Composition, Immune response -- Analysis, Transcription factors -- Analysis, Tryptophan metabolism -- Health aspects, Health
Abstract

2023 JUL 29 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Fresh data on amino acids are presented in a new report. According [...]

Published
2023

12. Researchers' Work from Shandong University Focuses on Transcription Factors (Apoc1 Exacerbates Renal Fibrosis Through the Activation of the Nf-kappa B Signaling Pathway In Igan)

Subjects
Fibrosis -- Risk factors -- Prevention, IgA glomerulonephritis -- Complications and side effects -- Care and treatment, Transcription factors -- Analysis, DNA binding proteins -- Analysis, Health
Abstract

2023 JUL 22 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Researchers detail new data in Proteins - Transcription Factors. According to news [...]

Published
2023

13. University of Madras Researchers Report on Findings in Type 2 Diabetes (Molecular characterization and re-interpretation of HNF1A variants identified in Indian MODY subjects towards precision medicine)

Subjects
Genomic structural variations -- Analysis, Type 2 diabetes -- Diagnosis -- Care and treatment, Transcription factors -- Analysis, Health
Abstract

2023 JUL 8 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Fresh data on type 2 diabetes are presented in a new report. [...]

Published
2023

14. University of Mysore Researcher Provides New Insights into Chronic Myelogenous Leukemia (Methyl-Thiol-Bridged Oxadiazole and Triazole Heterocycles as Inhibitors of NF-kB in Chronic Myelogenous Leukemia Cells)

Subjects
Cell proliferation -- Health aspects, Chronic myeloid leukemia -- Diagnosis -- Care and treatment, Heterocyclic aromatic compounds -- Dosage and administration, Transcription factors -- Analysis, Health
Abstract

2023 JUL 1 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Data detailed on chronic myelogenous leukemia have been presented. According to news [...]

Published
2023

15. Postgraduate Institute of Medical Education and Research Researchers Broaden Understanding of Genetics (Investigating the novel-binding site of RPA2 on Menin and predicting the effect of point mutation of Menin through protein-protein ...)

Subjects
Tumor suppressor genes -- Analysis, Protein-protein interactions -- Analysis, Transcription factors -- Analysis, Health
Abstract

2023 JUL 1 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- New research on genetics is the subject of a new report. According [...]

Published
2023

16. Study Data from Ulm University Provide New Insights into Transcription Factors (Nf-kappa B Is a Critical Mediator of Post-mitotic Senescence In Oligodendrocytes and Subsequent White Matter Loss)

Subjects
Aging -- Health aspects, Nervous system -- Degeneration, Transcription factors -- Analysis, DNA binding proteins -- Analysis, Health
Abstract

2023 JUN 17 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Data detailed on Proteins - Transcription Factors have been presented. According to [...]

Published
2023

17. Researchers from Seattle Children's Research Institute Detail Findings in Machine Learning (Machine Learning Prediction of Non-coding Variant Impact In Human Retinal Cis-regulatory Elements)

Subjects
Genetic variation -- Analysis, Machine learning -- Methods, Retinal diseases -- Risk factors -- Prevention, Transcription factors -- Analysis, Health
Abstract

2023 JUN 17 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Researchers detail new data in Machine Learning. According to news reporting from [...]

Published
2023

18. Researchers from Aix-Marseille University Describe Research in Cardiovascular Research (* * Nkx2-5* * Loss of Function in the His-Purkinje System Hampers Its Maturation and Leads to Mechanical Dysfunction)

Subjects
Gene expression -- Analysis, Heart function tests -- Analysis, Cardiovascular diseases -- Risk factors -- Prevention -- Genetic aspects, Transcription factors -- Analysis, Health
Abstract

2023 JUN 17 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Investigators discuss new findings in cardiovascular research. According to news reporting out [...]

Published
2023

19. Ohio State University Researcher Broadens Understanding of Acute Kidney Injury (ZFP24 drives SOX9 upregulation and protects tubular epithelial cells during acute kidney injury)

Subjects
Zinc finger proteins -- Analysis, Embryonic development -- Health aspects, Homeostasis -- Health aspects, Acute renal failure -- Risk factors -- Prevention, Transcription factors -- Analysis, Health
Abstract

2023 JUN 17 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Investigators discuss new findings in acute kidney injury. According to news reporting [...]

Published
2023

20. Studies from Hamad Medical Corporation Yield New Information about Cancer (Long Non-coding Rnas Regulated Nf-kappa B Signaling In Cancer Metastasis: Micromanaging By Not so Small Non-coding Rnas)

Subjects
Metastasis -- Risk factors -- Prevention, Inflammation -- Care and treatment, Transcription factors -- Analysis, Health
Abstract

2023 JUN 3 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Research findings on Cancer are discussed in a new report. According to [...]

Published
2023

21. Studies from Catholic University of America Yield New Data on Life Science (A Twist-box Domain of the C. Elegans Twist Homolog, Hlh-8, Plays a Complex Role In Transcriptional Regulation)

Subjects
Caenorhabditis elegans -- Identification and classification -- Control, Protein-protein interactions -- Analysis, Transcription factors -- Analysis, Phenotype -- Analysis, Health
Abstract

2023 JUN 3 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- A new study on Life Science is now available. According to news [...]

Published
2023

22. Reports from Huazhong University of Science and Technology Describe Recent Advances in Neuroblastomas (Therapeutic targeting of CNBP phase separation inhibits ribosome biogenesis and neuroblastoma progression via modulating SWI/SNF complex ...)

Subjects
Binding proteins -- Analysis, Mass spectrometry -- Analysis, Neuroblastoma -- Diagnosis -- Care and treatment, Transcription factors -- Analysis, Health
Abstract

2023 MAY 20 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- New study results on neuroblastomas have been published. According to news originating [...]

Published
2023

23. Research from Brigham and Women's Hospital Yields New Data on Chordomas (High-Throughput/High Content Imaging Screen Identifies Novel Small Molecule Inhibitors and Immunoproteasomes as Therapeutic Targets for Chordoma)

Subjects
Tumors, Embryonal -- Diagnosis -- Care and treatment -- Genetic aspects, High-throughput screening (Biochemical assaying) -- Methods, Transcription factors -- Analysis, Health
Abstract

2023 MAY 13 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Research findings on chordomas are discussed in a new report. According to [...]

Published
2023

24. New Findings from Fujian Normal University Describe Advances in Antineoplastics (Contribution of HIF-1a/BNIP3-mediated autophagy to lipid accumulation during irinotecan-induced liver injury)

Subjects
Antineoplastic agents -- Dosage and administration, Hypoxia -- Risk factors -- Prevention, Transcription factors -- Analysis, Antimitotic agents -- Dosage and administration, Physiology, Pathological -- Analysis, Health
Abstract

2023 MAY 13 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Current study results on antineoplastics have been published. According to news originating [...]

Published
2023

25. New Findings from Fujian Medical University Update Understanding of Liver Cancer (Sumoylated Il-33 In the Nucleus Stabilizes the Transcription Factor Irf1 In Hepatocellular Carcinoma Cells To Promote Immune Escape)

Subjects
Post-translational modification -- Analysis, Interleukins -- Analysis, Hepatoma -- Diagnosis -- Care and treatment, Transcription factors -- Analysis, Health
Abstract

2023 MAY 13 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Investigators discuss new findings in Oncology - Liver Cancer. According to news [...]

Published
2023

26. Sungkyunkwan University School of Medicine Researcher Adds New Data to Research in Cancer (Abstract LB282: RUNX2 is a master transcription factor that determines the identity of cancer-associated fibroblast subtypes with abnormal activation in ...)

Subjects
RNA sequencing -- Analysis, Cancer -- Diagnosis, Fibroblasts -- Health aspects, Transcription factors -- Analysis, Health
Abstract

2023 MAY 6 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Current study results on cancer have been published. According to news reporting [...]

Published
2023

27. Study Data from Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management Update Understanding of Cancer (The Role of Natural Flavonoids as Telomerase Inhibitors in Suppressing Cancer Growth)

Subjects
Cell proliferation -- Health aspects, Cancer -- Diagnosis, Tumor suppressor genes -- Analysis, Telomerase -- Analysis, Transcription factors -- Analysis, Health
Abstract

2023 MAY 6 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- A new study on cancer is now available. According to news originating [...]

Published
2023

28. Reports on Transcription Factors Findings from Northeast Agricultural University Provide New Insights [Overexpression of a Fragaria Vesca 1r-myb Transcription Factor Gene (Fvmyb114) Increases Salt and Cold Tolerance In Arabidopsis Thaliana]

Subjects
Strawberries -- Growth -- Diseases and pests -- Genetic aspects, Arabidopsis thaliana -- Identification and classification -- Control, Transcription factors -- Analysis, DNA binding proteins -- Analysis, Company growth, Health
Abstract

2023 MAY 6 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Current study results on Proteins - Transcription Factors have been published. According [...]

Published
2023

29. Frequent mutations that converge on the NFKBIZ pathway in ulcerative colitis

Author

Kakiuchi, Nobuyuki, Yoshida, Kenichi, Uchino, Motoi, Kihara, Takako, Akaki, Kotaro, Inoue, Yoshikage, and Kawada, Kenji

Subjects
Gene mutations -- Forecasts and trends, Ulcerative colitis -- Genetic aspects, Transcription factors -- Analysis, Market trend/market analysis, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Chronic inflammation is accompanied by recurring cycles of tissue destruction and repair and is associated with an increased risk of cancer.sup.1-3. However, how such cycles affect the clonal composition of tissues, particularly in terms of cancer development, remains unknown. Here we show that in patients with ulcerative colitis, the inflamed intestine undergoes widespread remodelling by pervasive clones, many of which are positively selected by acquiring mutations that commonly involve the NFKBIZ, TRAF3IP2, ZC3H12A, PIGR and HNRNPF genes and are implicated in the downregulation of IL-17 and other pro-inflammatory signals. Mutational profiles vary substantially between colitis-associated cancer and non-dysplastic tissues in ulcerative colitis, which indicates that there are distinct mechanisms of positive selection in both tissues. In particular, mutations in NFKBIZ are highly prevalent in the epithelium of patients with ulcerative colitis but rarely found in both sporadic and colitis-associated cancer, indicating that NFKBIZ-mutant cells are selected against during colorectal carcinogenesis. In further support of this negative selection, we found that tumour formation was significantly attenuated in Nfkbiz-mutant mice and cell competition was compromised by disruption of NFKBIZ in human colorectal cancer cells. Our results highlight common and discrete mechanisms of clonal selection in inflammatory tissues, which reveal unexpected cancer vulnerabilities that could potentially be exploited for therapeutics in colorectal cancer. In patients with ulcerative colitis, chronic inflammation can lead to remodelling of the colorectal epithelium through positive selection of clones with mutations in genes related to IL-17 signalling, which, however, might be negatively selected during colitis-associated carcinogenesis., Author(s): Nobuyuki Kakiuchi [sup.1] [sup.2] [sup.3] , Kenichi Yoshida [sup.1] , Motoi Uchino [sup.4] , Takako Kihara [sup.5] , Kotaro Akaki [sup.6] , Yoshikage Inoue [sup.1] [sup.2] [sup.7] , Kenji [...]

Published
2020
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31. Studies from University of Colorado Anschutz Medical Campus Provide New Data on Cancer Research (Cell Differentiation Modifies the P53 Transcriptional Program Through a Combination of Gene Silencing and Constitutive Transactivation)

Subjects
Gene silencing -- Methods -- Usage, Cell differentiation -- Influence, Transcription factors -- Analysis, Health
Abstract

2023 MAR 11 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Investigators publish new report on Cancer Research. According to news reporting out [...]

Published
2023

32. Findings from University College of Engineering in the Area of Transcription Factors Described [Identification of Galangin As the Bioactive Compound From Alpinia Calcarata (Haw.) Roscoe Rhizomes To Inhibit Irak-1/mapk/nf-kappa B P65 and Jak-1 ...]

Subjects
Diabetes therapy -- Methods, Molecular mechanics -- Analysis, Transcription factors -- Analysis, Galangal -- Usage -- Health aspects, DNA binding proteins -- Analysis, Health
Abstract

2023 MAR 4 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Researchers detail new data in Proteins - Transcription Factors. According to news [...]

Published
2023

33. Researchers at Tianjin Medical University Report New Data on Lung Cancer (Dnase1l3 Regulation By Transcription Factor Foxp2 Affects the Proliferation, Migration, Invasion and Tube Formation of Lung Adenocarcinoma)

Subjects
Gene expression -- Analysis, Metastasis -- Risk factors -- Prevention, Lung cancer -- Development and progression -- Care and treatment -- Genetic aspects, Transcription factors -- Analysis, Health
Abstract

2023 FEB 25 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Researchers detail new data in Oncology - Lung Cancer. According to news [...]

Published
2023

34. Reports Outline Drug Development Findings from Cold Spring Harbor Laboratory [A Synthetic Klhl20 Ligand To Validate Cul3(Klhl20) As a Potent E3 Ligase for Targeted Protein Degradation]

Subjects
Ubiquitin-proteasome system -- Analysis, Proteolysis -- Methods, Drug discovery -- Methods, Transcription factors -- Analysis, Health
Abstract

2023 FEB 25 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Research findings on Drugs and Therapies - Drug Development are discussed in [...]

Published
2023

35. Findings from Dalhousie University in Transcription Factors Reported (Loss of Transcription Factor Eb Dysregulates the G1/s Transition and Dna Replication In Mammary Epithelial Cells)

Subjects
DNA replication -- Health aspects, Cell cycle -- Analysis, Cancer -- Relapse, Transcription factors -- Analysis, Health
Abstract

2023 FEB 18 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Current study results on Proteins - Transcription Factors have been published. According [...]

Published
2023

36. Findings from Yantai Yuhuangding Hospital Biochip Laboratory in the Area of Obesity Reported (Identification of Key Genes From the Visceral Adipose Tissues of Overweight/obese Adults With Hypertension Through Transcriptome Sequencing)

Subjects
Obesity -- Complications and side effects, Gene expression -- Analysis, Transcription factors -- Analysis, Hypertension -- Risk factors -- Prevention -- Genetic aspects, Health
Abstract

2023 FEB 18 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Fresh data on Nutritional and Metabolic Diseases and Conditions - Obesity are [...]

Published
2023

37. Recent Findings in Nasopharyngeal Carcinoma Described by Researchers from University of Hong Kong (Epigenomic Landscape Study Reveals Molecular Subtypes and Ebv-associated Regulatory Epigenome Reprogramming In Nasopharyngeal Carcinoma)

Subjects
Nucleoproteins -- Analysis, RNA sequencing -- Analysis, Nasopharyngeal cancer -- Diagnosis -- Care and treatment, Transcription factors -- Analysis, Health
Abstract

2023 FEB 4 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Investigators discuss new findings in Oncology - Nasopharyngeal Carcinoma. According to news [...]

Published
2023

38. Researchers from Wuhan University Report Recent Findings in Sepsis (Nrf2 Deficiency Exacerbated Clp-induced Pulmonary Injury and Inflammation Through Autophagy- and Nf-kappa B/ppar Gamma-mediated Macrophage Polarization)

Subjects
Lung diseases -- Risk factors -- Diagnosis -- Care and treatment, Inflammation -- Care and treatment, Sepsis -- Complications and side effects, Macrophages -- Analysis, Transcription factors -- Analysis, Health
Abstract

2023 JAN 14 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Fresh data on Blood Diseases and Conditions - Sepsis are presented in [...]

Published
2023

39. Researchers at Shantou University Release New Data on Transcription Factors (Tanshinone Iia Inhibits Tissue Factor Expression Induced By Thrombin In Human Umbilical Vein Endothelial Cells Via Par-1 and P38 Mapk Signaling Pathway)

Subjects
Phosphorylation -- Health aspects, Thrombin -- Dosage and administration, Transcription factors -- Analysis, DNA binding proteins -- Analysis, Health
Abstract

2023 JAN 14 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Fresh data on Proteins - Transcription Factors are presented in a new [...]

Published
2023

40. Research Reports from Medical University of Vienna Provide New Insights into Chlamydia trachomatis (TLR4/CD14/MD2 Revealed as the Limited Toll-like Receptor Complex for * * Chlamydia trachomatis* * -Induced NF-kB Signaling)

Subjects
Immune response -- Analysis, Chlamydia infections -- Risk factors -- Prevention, Toll-like receptors -- Analysis, Transcription factors -- Analysis, Health
Abstract

2023 JAN 14 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Investigators publish new report on Chlamydia trachomatis. According to news originating from [...]

Published
2023

41. Bringing on the next wave of spatially resolved transcriptomics

Author

He, Jiang

Subjects
Molecular diagnostic techniques -- Evaluation, Data entry -- Methods -- Evaluation, Transcription factors -- Analysis, Business, Health care industry
Abstract

Diseases often originate in highly specific regions or cell types within the body. Why? Because healthy cells are not uniform: there are hundreds of different cell types that display different [...]

Published
2022

42. Researchers at Kyushu University Report New Data on Non-Small Cell Lung Cancer [Association of Thyroid Transcription Factor-1 (Ttf-1) Expression With Efficacy of Pd-1/pd-l1 Inhibitors Plus Pemetrexed and Platinum Chemotherapy In Advanced ...]

Subjects
Biochemistry -- Analysis, Pemetrexed -- Dosage and administration, Lung cancer, Non-small cell -- Diagnosis -- Care and treatment, Chemotherapy -- Patient outcomes, Cancer -- Chemotherapy, Transcription factors -- Analysis, Health
Abstract

2022 DEC 24 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Researchers detail new data in Oncology - Non-Small Cell Lung Cancer. According [...]

Published
2022

43. Reports Summarize Lung Cancer Findings from Shanxi Medical University (Significance of Thyroid Transcription Factor 1 and Napsin a for Prompting the Status of Egfr Mutations In Lung Adenocarcinoma Patients)

Subjects
Gene mutations -- Health aspects, Lymphatic metastasis -- Risk factors -- Prevention, Lung cancer -- Development and progression -- Care and treatment -- Genetic aspects, Transcription factors -- Analysis, Health
Abstract

2022 DEC 24 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Current study results on Oncology - Lung Cancer have been published. According [...]

Published
2022

44. New Non-Small Cell Lung Cancer Study Results Reported from First Affiliated Hospital of Soochow University (Exosome-transmitted circVMP1 facilitates the progression and cisplatin resistance of non-small cell lung cancer by targeting ...)

Subjects
Cell cycle -- Health aspects, Electron microscopy -- Methods, Lung cancer, Non-small cell -- Development and progression -- Care and treatment, Transcription factors -- Analysis, Health
Abstract

2022 DEC 17 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Investigators publish new report on non-small cell lung cancer. According to news [...]

Published
2022

45. Studies from Capital Medical University Yield New Information about Thyroid Cancer (Hif-1 Alpha and Caspase-3 Expression In Aggressive Papillary Thyroid Carcinoma)

Subjects
Cell proliferation -- Health aspects, Neovascularization -- Health aspects, Thyroid cancer -- Diagnosis -- Care and treatment, Apoptosis -- Health aspects, Transcription factors -- Analysis, Health
Abstract

2022 DEC 10 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Research findings on Oncology - Thyroid Cancer are discussed in a new [...]

Published
2022

46. Findings on Choledochal Cysts Reported by Investigators at Shanghai Jiao Tong University (Reduced Peroxisome Proliferator-activated Receptor-alpha and Bile Acid Nuclear Receptor Nr1h4/fxr May Affect the Hepatic Immune Microenvironment of ...)

Subjects
Gastrointestinal system -- Abnormalities, Peroxisomes -- Analysis, Lipid metabolism -- Health aspects, Transcription factors -- Analysis, Health
Abstract

2022 DEC 10 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Research findings on Digestive System Diseases and Conditions - Choledochal Cysts are [...]

Published
2022

47. Researchers' Work from King's College London Focuses on Facioscapulohumeral Muscular Dystrophy (Antagonism Between Dux4 and Dux4c Highlights a Pathomechanism Operating Through Beta-catenin In Facioscapulohumeral Muscular Dystrophy)

Subjects
Cell death -- Health aspects, Muscular dystrophy -- Development and progression -- Care and treatment -- Genetic aspects, Transcription factors -- Analysis, Muscles -- Medical examination, Health
Abstract

2022 NOV 26 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Fresh data on Musculoskeletal Diseases and Conditions - Facioscapulohumeral Muscular Dystrophy are [...]

Published
2022

48. Data from Tallinn University of Technology Broaden Understanding of Gene Therapy (Expression of alternative transcription factor 4 mRNAs and protein isoforms in the developing and adult rodent and human tissues)

Subjects
Proteomics -- Analysis, Gene therapy -- Patient outcomes, Messenger RNA -- Analysis, Transcription factors -- Analysis, Health
Abstract

2022 NOV 19 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Investigators publish new report on gene therapy. According to news reporting from [...]

Published
2022

49. New Findings from Peking University People's Hospital Describe Advances in Colon Cancer (Ppy@fe3o4 Nanoparticles Inhibit the Proliferation and Metastasis of Crc Via Suppressing the Nf-kappa B Signaling Pathway and Promoting Ferroptosis)

Subjects
Cell death -- Health aspects, Nanoparticles -- Usage -- Health aspects, Colorectal cancer -- Diagnosis -- Care and treatment, Tumor staging -- Methods, Iron oxides -- Properties, Transcription factors -- Analysis, Health
Abstract

2022 OCT 29 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Research findings on Oncology - Colon Cancer are discussed in a new [...]

Published
2022

50. Studies from State University of New York - Stony Brook University Yield New Data on Genetics (Knockout and Inhibition of Ape1: Roles of Ape1 in Base Excision DNA Repair and Modulation of Gene Expression)

Subjects
DNA repair -- Health aspects, Gene expression -- Analysis, Transcription factors -- Analysis, DNA polymerases -- Analysis, Health
Abstract

2022 OCT 15 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- New study results on genetics have been published. According to news reporting [...]

Published
2022

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