1. Rapidly evolving genome and epigenome editing technologies.
- Author
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Tran NT and Han R
- Subjects
- Humans, Epigenome, Animals, Transcription Activator-Like Effector Nucleases genetics, Transcription Activator-Like Effector Nucleases metabolism, DNA Breaks, Double-Stranded, Genetic Therapy methods, Gene Editing methods, CRISPR-Cas Systems
- Abstract
Genome editing technologies are rapidly evolving, from the early zinc-finger nucleases, transcription activator-like effector nucleases (TALENs), and CRISPR-Cas9 (Figure 1, initial genome editing technologies), which generate double-strand breaks (DSBs), to base editing, which makes precise nucleobase conversion without inducing DSBs, and prime editing, which can carry out all types of edits without DSBs or donor DNA templates. The emergence of these revolutionary technologies offers us unprecedented opportunities for biomedical research and therapy development., (Copyright © 2024 The American Society of Gene and Cell Therapy. Published by Elsevier Inc. All rights reserved.)
- Published
- 2024
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