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16 results on '"Tranah, G. J."'

1. Novel loci associated with usual sleep duration: the CHARGE Consortium Genome-Wide Association Study

Author

Gottlieb, D J, Hek, K, Chen, T-h, Watson, N F, Eiriksdottir, G, Byrne, E M, Cornelis, M, Warby, S C, Bandinelli, S, Cherkas, L, Evans, D S, Grabe, H J, Lahti, J, Li, M, Lehtimäki, T, Lumley, T, Marciante, K D, Pérusse, L, Psaty, B M, Robbins, J, Tranah, G J, Vink, J M, Wilk, J B, Stafford, J M, Bellis, C, Biffar, R, Bouchard, C, Cade, B, Curhan, G C, Eriksson, J G, Ewert, R, Ferrucci, L, Fülöp, T, Gehrman, P R, Goodloe, R, Harris, T B, Heath, A C, Hernandez, D, Hofman, A, Hottenga, J-J, Hunter, D J, Jensen, M K, Johnson, A D, Kähönen, M, Kao, L, Kraft, P, Larkin, E K, Lauderdale, D S, Luik, A I, Medici, M, Montgomery, G W, Palotie, A, Patel, S R, Pistis, G, Porcu, E, Quaye, L, Raitakari, O, Redline, S, Rimm, E B, Rotter, J I, Smith, A V, Spector, T D, Teumer, A, Uitterlinden, A G, Vohl, M-C, Widen, E, Willemsen, G, Young, T, Zhang, X, Liu, Y, Blangero, J, Boomsma, D I, Gudnason, V, Hu, F, Mangino, M, Martin, N G, O'Connor, G T, Stone, K L, Tanaka, T, Viikari, J, Gharib, S A, Punjabi, N M, Räikkönen, K, Völzke, H, Mignot, E, and Tiemeier, H

Published
2015
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2. Association of heat shock proteins with all-cause mortality

Author

Broer, L., Demerath, E. W., Garcia, M. E., Homuth, G., Kaplan, R. C., Lunetta, K. L., Tanaka, T., Tranah, G. J., Walter, S., Arnold, A. M., Atzmon, G., Harris, T. B., Hoffmann, W., Karasik, D., Kiel, D. P., Kocher, T., Launer, L. J., Lohman, K. K., Rotter, J. I., Tiemeier, H., Uitterlinden, A. G., Wallaschofski, H., Bandinelli, S., Dörr, M., Ferrucci, L., Franceschini, N., Gudnason, V., Hofman, A., Liu, Y., Murabito, J. M., Newman, A. B., Oostra, B. A., Psaty, B. M., Smith, A. V., and van Duijn, C. M.

Published
2013
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4. Genome-wide meta-analyses of smoking behaviors in African Americans

Author

Chen, G K, Bandera, E V, Chanock, S J, Blot, W J, Wessel, J, Deming, S L, Eaton, C B, Hamidovic, A, Buxbaum, S G, Nalls, M A, Bernstein, L, Diver, W R, Kasberger, J L, Ambrosone, C B, Thacker, E L, Becker, L, Broeckel, U, Tranah, G J, Sung, Y J, Bergen, A W, Brown, W M, Caporaso, N, Kim, Y, Evans, M K, Arnett, D, Berndt, S I, Fornage, M, Petruzella, S, Becker, D M, Casey, G, David, S P, and Evans, D S

Abstract

The identification and exploration of genetic loci that influence smoking behaviors have been conducted primarily in populations of the European ancestry. Here we report results of the first genome-wide association study meta-analysis of smoking behavior in African Americans in the Study of Tobacco in Minority Populations Genetics Consortium (n=32 389). We identified one non-coding single-nucleotide polymorphism (SNP; rs2036527[A]) on chromosome 15q25.1 associated with smoking quantity (cigarettes per day), which exceeded genome-wide significance (β=0.040, s.e.=0.007, P=1.84 × 10−8). This variant is present in the 5′-distal enhancer region of the CHRNA5 gene and defines the primary index signal reported in studies of the European ancestry. No other SNP reached genome-wide significance for smoking initiation (SI, ever vs never smoking), age of SI, or smoking cessation (SC, former vs current smoking). Informative associations that approached genome-wide significance included three modestly correlated variants, at 15q25.1 within PSMA4, CHRNA5 and CHRNA3 for smoking quantity, which are associated with a second signal previously reported in studies in European ancestry populations, and a signal represented by three SNPs in the SPOCK2 gene on chr10q22.1. The association at 15q25.1 confirms this region as an important susceptibility locus for smoking quantity in men and women of African ancestry. Larger studies will be needed to validate the suggestive loci that did not reach genome-wide significance and further elucidate the contribution of genetic variation to disparities in cigarette consumption, SC and smoking-attributable disease between African Americans and European Americans.

Published
2012
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5. Novel loci associated with usual sleep duration: the CHARGE Consortium Genome-Wide Association Study

Author

Gottlieb, D J, primary, Hek, K, additional, Chen, T-h, additional, Watson, N F, additional, Eiriksdottir, G, additional, Byrne, E M, additional, Cornelis, M, additional, Warby, S C, additional, Bandinelli, S, additional, Cherkas, L, additional, Evans, D S, additional, Grabe, H J, additional, Lahti, J, additional, Li, M, additional, Lehtimäki, T, additional, Lumley, T, additional, Marciante, K D, additional, Pérusse, L, additional, Psaty, B M, additional, Robbins, J, additional, Tranah, G J, additional, Vink, J M, additional, Wilk, J B, additional, Stafford, J M, additional, Bellis, C, additional, Biffar, R, additional, Bouchard, C, additional, Cade, B, additional, Curhan, G C, additional, Eriksson, J G, additional, Ewert, R, additional, Ferrucci, L, additional, Fülöp, T, additional, Gehrman, P R, additional, Goodloe, R, additional, Harris, T B, additional, Heath, A C, additional, Hernandez, D, additional, Hofman, A, additional, Hottenga, J-J, additional, Hunter, D J, additional, Jensen, M K, additional, Johnson, A D, additional, Kähönen, M, additional, Kao, L, additional, Kraft, P, additional, Larkin, E K, additional, Lauderdale, D S, additional, Luik, A I, additional, Medici, M, additional, Montgomery, G W, additional, Palotie, A, additional, Patel, S R, additional, Pistis, G, additional, Porcu, E, additional, Quaye, L, additional, Raitakari, O, additional, Redline, S, additional, Rimm, E B, additional, Rotter, J I, additional, Smith, A V, additional, Spector, T D, additional, Teumer, A, additional, Uitterlinden, A G, additional, Vohl, M-C, additional, Widen, E, additional, Willemsen, G, additional, Young, T, additional, Zhang, X, additional, Liu, Y, additional, Blangero, J, additional, Boomsma, D I, additional, Gudnason, V, additional, Hu, F, additional, Mangino, M, additional, Martin, N G, additional, O'Connor, G T, additional, Stone, K L, additional, Tanaka, T, additional, Viikari, J, additional, Gharib, S A, additional, Punjabi, N M, additional, Räikkönen, K, additional, Völzke, H, additional, Mignot, E, additional, and Tiemeier, H, additional

Published
2014
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8. Genome-wide meta-analyses of smoking behaviors in African Americans

Author

David, S P, primary, Hamidovic, A, additional, Chen, G K, additional, Bergen, A W, additional, Wessel, J, additional, Kasberger, J L, additional, Brown, W M, additional, Petruzella, S, additional, Thacker, E L, additional, Kim, Y, additional, Nalls, M A, additional, Tranah, G J, additional, Sung, Y J, additional, Ambrosone, C B, additional, Arnett, D, additional, Bandera, E V, additional, Becker, D M, additional, Becker, L, additional, Berndt, S I, additional, Bernstein, L, additional, Blot, W J, additional, Broeckel, U, additional, Buxbaum, S G, additional, Caporaso, N, additional, Casey, G, additional, Chanock, S J, additional, Deming, S L, additional, Diver, W R, additional, Eaton, C B, additional, Evans, D S, additional, Evans, M K, additional, Fornage, M, additional, Franceschini, N, additional, Harris, T B, additional, Henderson, B E, additional, Hernandez, D G, additional, Hitsman, B, additional, Hu, J J, additional, Hunt, S C, additional, Ingles, S A, additional, John, E M, additional, Kittles, R, additional, Kolb, S, additional, Kolonel, L N, additional, Le Marchand, L, additional, Liu, Y, additional, Lohman, K K, additional, McKnight, B, additional, Millikan, R C, additional, Murphy, A, additional, Neslund-Dudas, C, additional, Nyante, S, additional, Press, M, additional, Psaty, B M, additional, Rao, D C, additional, Redline, S, additional, Rodriguez-Gil, J L, additional, Rybicki, B A, additional, Signorello, L B, additional, Singleton, A B, additional, Smoller, J, additional, Snively, B, additional, Spring, B, additional, Stanford, J L, additional, Strom, S S, additional, Swan, G E, additional, Taylor, K D, additional, Thun, M J, additional, Wilson, A F, additional, Witte, J S, additional, Yamamura, Y, additional, Yanek, L R, additional, Yu, K, additional, Zheng, W, additional, Ziegler, R G, additional, Zonderman, A B, additional, Jorgenson, E, additional, Haiman, C A, additional, and Furberg, H, additional

Published
2012
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9. Association of heat shock proteins with all-cause mortality

Author

Broer, L., primary, Demerath, E. W., additional, Garcia, M. E., additional, Homuth, G., additional, Kaplan, R. C., additional, Lunetta, K. L., additional, Tanaka, T., additional, Tranah, G. J., additional, Walter, S., additional, Arnold, A. M., additional, Atzmon, G., additional, Harris, T. B., additional, Hoffmann, W., additional, Karasik, D., additional, Kiel, D. P., additional, Kocher, T., additional, Launer, L. J., additional, Lohman, K. K., additional, Rotter, J. I., additional, Tiemeier, H., additional, Uitterlinden, A. G., additional, Wallaschofski, H., additional, Bandinelli, S., additional, Dörr, M., additional, Ferrucci, L., additional, Franceschini, N., additional, Gudnason, V., additional, Hofman, A., additional, Liu, Y., additional, Murabito, J. M., additional, Newman, A. B., additional, Oostra, B. A., additional, Psaty, B. M., additional, Smith, A. V., additional, and van Duijn, C. M., additional

Published
2012
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14. Genome-Wide Meta-Analyses of Smoking Behaviors in African Americans

Author

Hamidovic, A, Bergen, A W, Wessel, J, Kasberger, J L, Petruzella, S, Thacker, E L, Nalls, M A, Tranah, G J, Ambrosone, C B, Arnett, D, Bandera, E V, Becker, L, Berndt, S I, Blot, W J, Broeckel, U, Buxbaum, S G, Caporaso, N, Chanock, S J, Deming, S L, Diver, W R, Eaton, C B, Fornage, M, Franceschini, N, Hernandez, D G, Hitsman, B, Ingles, S A, Kittles, R, Kolb, S, Kolonel, L N, Le Marchand, L, Lohman, K K, McKnight, B, Millikan, R C, Neslund-Dudas, C, Nyante, S, Press, M, Psaty, B M, Rodriguez-Gil, J L, Rybicki, B A, Singleton, A B, Snively, B, Stanford, J L, Strom, S S, Swan, G E, Thun, M J, Yamamura, Y, Yanek, L R, Ziegler, R G, Zonderman, A B, Jorgenson, E, Haiman, C A, Furberg, H, David, S.P., Chen, G.K., Brown, W.M., Kim, Y., Sung, Y., Becker, D.M., Bernstein, L., Casey, G., Evans, D.S., Evans, M.K., Harris, T.B., Henderson, B.E., Hu, J.J., Hunt, S.C., John, E.M., Liu, Y., Murphy, A., Rao, D.C., Redline, Susan, Signorello, Lisa B., Smoller, Jordan W., Spring, B., Taylor, K.D., Wilson, A.F., Witte, J.S., Yu, K., and Zheng, W.

Abstract

The identification and exploration of genetic loci that influence smoking behaviors have been conducted primarily in populations of the European ancestry. Here we report results of the first genome-wide association study meta-analysis of smoking behavior in African Americans in the Study of Tobacco in Minority Populations Genetics Consortium (n=32 389). We identified one non-coding single-nucleotide polymorphism (SNP; rs2036527[A]) on chromosome 15q25.1 associated with smoking quantity (cigarettes per day), which exceeded genome-wide significance (\(\beta\)=0.040, s.e.=0.007, P=1.84 × 10\(^{−8}\)). This variant is present in the 5′-distal enhancer region of the CHRNA5 gene and defines the primary index signal reported in studies of the European ancestry. No other SNP reached genome-wide significance for smoking initiation (SI, ever vs never smoking), age of SI, or smoking cessation (SC, former vs current smoking). Informative associations that approached genome-wide significance included three modestly correlated variants, at 15q25.1 within PSMA4, CHRNA5 and CHRNA3 for smoking quantity, which are associated with a second signal previously reported in studies in European ancestry populations, and a signal represented by three SNPs in the SPOCK2 gene on chr10q22.1. The association at 15q25.1 confirms this region as an important susceptibility locus for smoking quantity in men and women of African ancestry. Larger studies will be needed to validate the suggestive loci that did not reach genome-wide significance and further elucidate the contribution of genetic variation to disparities in cigarette consumption, SC and smoking-attributable disease between African Americans and European Americans.

Published
2012
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15. Association of heat shock proteins with all-cause mortality

Author

Bandinelli, S., Garcia, M. E., Broer, L., Harris, T. B., Franceschini, N., Lunetta, K. L., Atzmon, G., Gudnason, V., Murabito, J. M., Ferrucci, L., Dörr, M., Newman, A. B., Lohman, K. K., Walter, S., Oostra, B. A., Psaty, B. M., Wallaschofski, H., Arnold, A. M., Demerath, E. W., Launer, L. J., Hoffmann, W., Tanaka, T., Karasik, D., Van Duijn, C. M., Rotter, J. I., Tiemeier, H., Kiel, D. P., Homuth, G., Kocher, T., Liu, Y., Hofman, A., Uitterlinden, A. G., Kaplan, R. C., Smith, A. V., and Tranah, G. J.

Subjects
3. Good health
Abstract

Experimental mild heat shock is widely known as an intervention that results in extended longevity in various models along the evolutionary lineage. Heat shock proteins (HSPs) are highly upregulated immediately after a heat shock. The elevation in HSP levels was shown to inhibit stress-mediated cell death, and recent experiments indicate a highly versatile role for these proteins as inhibitors of programmed cell death. In this study, we examined common genetic variations in 31 genes encoding all members of the HSP70, small HSP, and heat shock factor (HSF) families for their association with all-cause mortality. Our discovery cohort was the Rotterdam study (RS1) containing 5,974 participants aged 55years and older (3,174 deaths). We assessed 4,430 single nucleotide polymorphisms (SNPs) using the HumanHap550K Genotyping BeadChip from Illumina. After adjusting for multiple testing by permutation analysis, three SNPs showed evidence for association with all-cause mortality in RS1. These findings were followed in eight independent population-based cohorts, leading to a total of 25,007 participants (8,444 deaths). In the replication phase, only HSF2 (rs1416733) remained significantly associated with all-cause mortality. Rs1416733 is a known cis-eQTL for HSF2. Our findings suggest a role of HSF2 in all-cause mortality.Electronic supplementary materialThe online version of this article (doi:10.1007/s11357-012-9417-7) contains supplementary material, which is available to authorized users.

16. Genome-wide association meta-analysis identifies five novel loci for age-related hearing impairment

Author

Adolfo Correa, Dragana Vuckovic, Chuang Ming Li, Sheila R. Pratt, Vilmundur Gudnason, Robert C. Kaplan, Massimiliano Cocca, Giorgia Girotto, Frances M K Williams, Nona Sotoodehnia, Christopher Spankovich, T. Ryan Price, Charles E. Bishop, Johanna Jakobsdottir, W. T. Longstreth, Howard J. Hoffman, Karen Valle, Mark W. Christiansen, Erik Fransen, Helena R R Wells, John M. Schweinfurth, André G. Uitterlinden, Mohammad Arfan Ikram, Guy Van Camp, Daniel S. Evans, Paolo Gasparini, Linda Broer, Gregory J. Tranah, Marco Brumat, Andries Paul Nagtegaal, Mike A. Nalls, Mary Rachel Stimson, Sudha Seshadri, Gudny Eiriksdottir, Karen J. Cruickshanks, Yan Gao, Nancy L. Heard-Costa, Nuno R. Zilhão, James G. Wilson, Nathan Pankratz, André Goedegebure, Claire J. Steves, Otorhinolaryngology and Head and Neck Surgery, Internal Medicine, Epidemiology, Nagtegaal, A. P., Broer, L., Zilhao, N. R., Jakobsdottir, J., Bishop, C. E., Brumat, M., Christiansen, M. W., Cocca, M., Gao, Y., Heard-Costa, N. L., Evans, D. S., Pankratz, N., Pratt, S. R., Price, T. R., Spankovich, C., Stimson, M. R., Valle, K., Vuckovic, D., Wells, H., Eiriksdottir, G., Fransen, E., Ikram, M. A., Li, C. -M., Longstreth, W. T., Steves, C., Van Camp, G., Correa, A., Cruickshanks, K. J., Gasparini, P., Girotto, G., Kaplan, R. C., Nalls, M., Schweinfurth, J. M., Seshadri, S., Sotoodehnia, N., Tranah, G. J., Uitterlinden, A. G., Wilson, J. G., Gudnason, V., Hoffman, H. J., Williams, F. M. K., and Goedegebure, A.

Subjects
0301 basic medicine, Male, Aging, Auditory Pathways, Genome-wide association study, Audiology, Genome-wide association studies, Mice, 0302 clinical medicine, Genetics research, GWAS, age-related hearing lo, Multidisciplinary, Middle Aged, Phenotype, age-related hearing loss, Meta-analysis, Medicine, Female, medicine.symptom, medicine.medical_specialty, Hearing loss, Science, Single-nucleotide polymorphism, Biology, Article, ARHL, 03 medical and health sciences, medicine, otorhinolaryngologic diseases, SNP, Animals, Humans, Genetic Predisposition to Disease, Hearing Loss, Gene, Reproducibility of Results, Molecular Sequence Annotation, Genetic architecture, 030104 developmental biology, Gene Expression Regulation, Genetic Loci, Human medicine, 030217 neurology & neurosurgery, Genome-Wide Association Study
Abstract

Previous research has shown that genes play a substantial role in determining a person’s susceptibility to age-related hearing impairment. The existing studies on this subject have different results, which may be caused by difficulties in determining the phenotype or the limited number of participants involved. Here, we have gathered the largest sample to date (discovery n = 9,675; replication n = 10,963; validation n = 356,141), and examined phenotypes that represented low/mid and high frequency hearing loss on the pure tone audiogram. We identified 7 loci that were either replicated and/or validated, of which 5 loci are novel in hearing. Especially the ILDR1 gene is a high profile candidate, as it contains our top SNP, is a known hearing loss gene, has been linked to age-related hearing impairment before, and in addition is preferentially expressed within hair cells of the inner ear. By verifying all previously published SNPs, we can present a paper that combines all new and existing findings to date, giving a complete overview of the genetic architecture of age-related hearing impairment. This is of importance as age-related hearing impairment is highly prevalent in our ageing society and represents a large socio-economic burden.

Published
2019

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