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114 results on '"Tran, Thao T.D."'

15. Blueberry supplementation in neuronal health and protective technologies for efficient delivery of blueberry anthocyanins

Author

Tran, Phuong H.L., Tran, Thao T.D., Tran, Phuong H.L., and Tran, Thao T.D.

Abstract

Blueberries are consumed as healthy fruits that provide a variety of benefits to the nervous system. Scientists have found that blueberries can be used as a daily edible source for supplementation to prevent and minimize complexities of age-related diseases as well as to improve learning and memory in children. Anthocyanins are the most mentioned compounds among the components in blueberries, as they play a major role in providing the health benefits of this fruit. However, while they are highly active in impeding biological impairment in neuronal functions, they have poor bioavailability. This review focuses on neurological investigations of blueberries from in vitro cell studies to in vivo studies, including animal and human studies, with respect to their positive outcomes of neuroprotection and intervention in neurodegenerative conditions. Readers will also find information on the bioavailability of anthocyanins and the considerable factors affecting them so that they can make informed decisions regarding the daily consumption of blueberries. In this context, the ways in which blueberries or blueberry supplementation forms are consumed and which of these forms is best for maximizing the health benefits of blueberries should be considered important decision-making factors in the consumption of blueberries; all of these aspects are covered in this review. Finally, we discuss recent technologies that have been employed to improve the bioavailability of blueberry anthocyanins in the development of effective delivery vehicles supporting brain health.

Published
2021

35. Lead compounds in the context of extracellular vesicle research

Author

Tran, Thao T.D., Tran, Ha Lien Phuong, Tran, Thao T.D., and Tran, Ha Lien Phuong

Abstract

Studies of small extracellular vesicles (sEVs), known as exosomes, have been flourishing in the last decade with several achievements, from advancing biochemical knowledge to use in biomedical applications. Physiological changes of sEVs due to the variety of cargos they carry undoubtedly leave an impression that affects the understanding of the mechanism underlying disease and the development of sEV-based shuttles used for treatments and non-invasive diagnostic tools. Indeed, the remarkable properties of sEVs are based on their nature, which helps shield them from recognition by the immune system, protects their payload from biochemical degradation, and contributes to their ability to translocate and convey information between cells and their inherent ability to target disease sites such as tumors that is valid for sEVs derived from cancer cells. However, their transport, biogenesis, and secretion mechanisms are still not thoroughly clear, and many ongoing investigations seek to determine how these processes occur. On the other hand, lead compounds have been playing critical roles in the drug discovery process and have been recently employed in studies of the biogenesis and secretion of sEVs as external agents, affecting sEV release and serving as drug payloads in sEV drug delivery systems. This article gives readers an overview of the roles of lead compounds in these two research areas of sEVs, the rising star in studies of nanoscale medicine.

Published
2020

50. Release Kinetics of Hydroxypropyl Methylcellulose Governing DrugRelease and Hydrodynamic Changes of Matrix Tablet

Author

Park, Chulhun, Lee, Jong Hoon, Jin, Gang, Ngo, Hai Van, Park, Jun-Bom, Tran, Thao T.D., Tran, Phuong H.L., and Lee, Beom-Jin

Abstract

Background: Hydrophilic Hydroxypropyl Methylcellulose (HPMC) matrix tablets arethe standard role model of the oral controlled-release formulation. Nevertheless, the HPMC kineticsfor the mechanistic understanding of drug release and hydrodynamic behaviors are rarely investigated.This study aims to investigate the release behaviors of both HPMC and paracetamol(model drug) from the hydrophilic matrix tablet. Methods: Two different viscosity grades of HPMC were used (Low viscosity: 6 cps, High viscosity:4,000 cps). Three different ratios of drug/HPMC (H:38.08%, M:22.85%, and L:15.23% (w/w)of HPMC amounts in total weight) matrix tablets were prepared by wet granulation technique. Therelease profiles of the drug and HPMC in a matrix tablet were quantitatively analyzed by HPLCand 1H-Nuclear Magnetic Resonance (NMR) spectroscopy. The hydrodynamic changes of HPMCwere determined by the gravimetric behaviors such as swelling and erosion rates, gel layer thickness,front movement data,and distributive Near-Infrared (NIR) chemical imaging of HPMC in amatrix tablet during the dissolution process. Results: High viscosity HPMC tablets showed slower release of HPMC than the release rate ofdrug, suggesting that drug release preceded polymer release.Different hydration phenomenon wasqualitatively identified and corresponded to the release profiles. The release behaviors of HPMCand drug in the tablet could be distinguished with the significant difference with fitted dissolutionkinetics model (Low viscosity HPMC 6cps; Korsmeyer-Peppas model, High viscosity HPMC4000cps; Hopfenberg model, Paracetamol; Weibull model) according to the weight of ingredientsand types of HPMC. Conclusion: The determination of HPMC polymer release correlating with drug release, hydrodynamicbehavior, and NIR chemical imaging of HPMC can provide new insights into the drug release-modulating mechanism in the hydrophilic matrix system.

Published
2022
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