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2. Abstracts of posters

Author

Suffisseau L., Taugourdeau M. C., Goldstein F. W., Mainardi J. L., Larrouturou Ph., Romero, M., Cervino, A. R., Albertone, G., Di Pasquale, R., Venturini, F., Congedo, R., Benettolo, F., Pistolesi, C., Olivato, R., Casasin T., Agusti C., Gurrera M. T., Fabregas X., Rizo A., Badia J. M., Santa-Olalla M., Marini, P., Rampazzo, R., Scroccaro, G., Dell'Aera, M., Luzzi, R., Ciccarone, G., Martinet, N., Beney, J., Marty, S., Reymond, J. -Ph., Cairns, Chris, Morgutti M., Posco M., Moltempi M., Lonqhini P., Rossignoli A., Rihet, P., Carles, G., Braguer, D., Azulay, J. P., Pouget, J., Pelletier, J., Crevat, A., Past.o, L., Barroso, E., Pujol, R., Ferrer, I., Ibars, M., Llop, J. M., Frankfort, Ellen, van Dongen, Robert T. M., Hekster, Yechiel A., Kart, T., Rasmussen, M., Horn, A., Wested, L., Gagyi, O., Markó, E., Regazzi M. B., Martinelli L., Goggi C., Bellotti E., Molinaro M., Rinaldi M., Gavazzi A., Buggia I., Daneri A., Guarnone E., Bascapē V., Viganô M., Lazzaro, A., Palozzo, A., Banfi R., Borselli G., Fabbiani P., Marinai C., Delorme, J., Tubiana, N., Buck, M., Chinot, O., De Wever, C., Robays, H., Montoro J. B., Flores G., Juárez J. C., Juste C., Jardí R., Altisent C., Tusell J. M., Arpinelli, F., De Carli, G., Olivieri, A., Recchia, G., Rossignoli A., Longhini P., La Guidara C., Russo B., Moltempi M., Tamés, M. J., Cajaraville, G., Ponz, L., Echaniz, E., Garcia, B., van Mil, J. W. Foppe, Leufkens, Hubert G., v. Haelst, Ingrid M. M., Parel, Piet C. M., Scholten, Wim K., Sessink, F. G. M., Raschatt, R., Traversa, G., Donini, G., Arpino, C., Da Cas, R., Pasquin, P., Bernadotte af Wisborg G., Claesson C., Lundberg O., Thorslund M., Ferraro L., Marrazzo E., Ostino G., Tognoni G., Heerdink, Eibert R., Koppedraaijer, Corrie, Bakker, Albert, Bidoli E., Battistin M., Troncon M. G., Franceschi S., Serraino D., Marino, M., Matera, M. G., Berrino, L., Contaldi, C., Piucci, B., Rossi, F., Rolle C., Marrazzo E. 0., Murgia, V., Bussi, R., Schievano, P., Pedrini, A., Baraghini, M., Benini, A., Cataldo, M. M., Galletti, P., Magnani, M., Manzoli, M., Novi, M. V., Pezzi, O., Font M., Salmaso A. B., Mezzalira L., Braybrook, Saran, Walker, Roger, van Mil, J. W. F., Tromp, F. T. J., de Jong-v.d. Berg, L. T. W., Bakker, A., Paes, A. H. P., Soe-Agnie, C., Llopis, P., Tortajada, J. J., Font, I., Climente, M., Real, J. V., Almenar, D., Molins, C., Jiménez, N. V., Bellés Medall MD, Casterá Melchor DE, Marco Sena MA, Cantarinz Marti I., Abad Gimeno FJ, Török, J., Thurzó, L., Juárez J. C., Oliveras M., Hidalgo E., Cabañas M. J., Barroso C., Moraga F. A., Sánchez de Toledo J., Kollöffel, W. J., Driessen, F. G. W. H. M., Goldhoorn, P. B., Moral, M. A., Roglan, A., Mangues, M. A., Bonal, J., Clopés, A., Badell, I., Fraga, G., Deinum, J. T., van Lingen, R. A., Quak, J. M. E., Kuizenga, A. J., van Dam, J. G., Villani P., Maserati R., Viale P., Alberici F., Iacona I., Wasieczko, A., Szymura-Oleksiak, J., Wyska, E., Magulova, L., Sirotiakova, J., Letkovicova, M., Branger, E., Besse, D., Blin, O., Bille, F., Serratrice, G., Desnuelle, C., Grassin, J., Reben, I., Meunier, Ph., Antier, D., Berthet, M., Søndergaard B., Herborg H., Frøkjær B., Hepler C., Steckner, H., Bergold, A., Drings, P., Märkel, A., Manegold, C., Venning, Mary, Pazzagli, Luciana, Semmola, Maria Vittoria, Mannoni, Alessandro, Tersen I., Huchet J., Sevilla, E., Ferrari, J. M., Herreros de Tejada, A., Congedo, R., Font, M., Fraccaro, A., Osti, M., Pappagallo, G., Spolaor, A., Terrazzani, G., Vezzani, M., Edouard B., Laine G., Geeraerts D., Robays H., Carrera-Hueso, F. J., Font, B., Marquina, C., Idoate, A., Giráldez, J., Fernández, E., Lacasa, C., Guzzo, D., Martini, N., Boya, P. Giner, González, M. M. Negredo, Agulló, J. Muñoz, Mansilla, L. Lorente, Nahata, Milap C., Troncon, M. G., Cattaruzzi, C., Bilbao G., Galende I., Atañé C., Bermudez de Castro A., Delgado O., Escribano B., Frías J., Gabriel R., Gómez J. A., Gracia D., Gutiérrez E., Hellín T., Izquierdo J. L., Moreno A., Requena T., Sainz-Terreros M., Tejedor J. C., Torralba A., Vigil D., Scuffi, C., Trallori, G., Messori, A., Bardazzi, G., Bonanomi, A., Silvano, R., D'Albasio, G., Bardelli, F., Verona, Firenzee, Bardelli, F., Corrado, A., Ferriols R., Aleixander M. J., Garcia J., Faus M., Ibañez E., Alós M., Rinaldi, M., Pharmacy & Therapeutic Committee (Ps&TC), Collaborative Group, SIFO-Veneto Working Group on Clinical Trials, Working Group on the Elaboration of an Approval Conditions Document to certify the Clinical Trials Ethics Committees in the Autonomous Community of Madrid, and Area SIFO di Metanalisi

Published
1994
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7. Incidence of inflammatory bowel disease in Italy: a nationwide population-based study

Author

Tragnone, A, Corrao, G, Miglio, F, Caprilli, R, Lanfranchi, G, Venerato, S, Elmi, G, D'Albasio, G, Paladini, I, Salvadori, G, Trallori, G, Valpiani, D, Rosoni, R, Ferrau, O, Mastronardi, M, Rigo, G, Gagliardi, G, Riegler, G, Di Leo, V, D'Inca, R, Sturniolo, G, Tragnone A., Corrao G., Miglio F., Caprilli R., Lanfranchi G. A., Venerato S., Elmi G., D'Albasio G., Paladini I., Salvadori G., Trallori G., Valpiani D., Rosoni R., Ferrau O., Mastronardi M., Rigo G. P., Gagliardi G., Riegler G., Di Leo V., D'Inca R., Sturniolo G., Tragnone, A, Corrao, G, Miglio, F, Caprilli, R, Lanfranchi, G, Venerato, S, Elmi, G, D'Albasio, G, Paladini, I, Salvadori, G, Trallori, G, Valpiani, D, Rosoni, R, Ferrau, O, Mastronardi, M, Rigo, G, Gagliardi, G, Riegler, G, Di Leo, V, D'Inca, R, Sturniolo, G, Tragnone A., Corrao G., Miglio F., Caprilli R., Lanfranchi G. A., Venerato S., Elmi G., D'Albasio G., Paladini I., Salvadori G., Trallori G., Valpiani D., Rosoni R., Ferrau O., Mastronardi M., Rigo G. P., Gagliardi G., Riegler G., Di Leo V., D'Inca R., and Sturniolo G.

Abstract

BACKGROUND: The epidemiology of inflammatory bowel disease (IBD) in Southern Europe is still unclear. Sporadic reports suggest a lower incidence of IBD in Italy than in other Western Countries and the USA. METHODS: A nationwide population-based study was carried out to estimate IBD incidence rates in eight Italian cities. All new cases of IBD diagnosed over 4 years in the target populations were collected from multiple information sources. RESULTS: From 1989 to 1992, 509 ulcerative colitis (UC), 222 Crohn's disease (CD) and 10 undefined IBD cases were collected, giving age-adjusted incidence rates (per 100,000 per year) of 5.2 for UC and 2.3 for CD. Using the capture-recapture method, an estimated completeness of 0.81 was obtained for case archives, without appreciable and significant differences between areas. The rates computed after correcting underestimation were 6.8 for UC and 2.8 for CD. The sex ratio M/F was 1.7 for UC and 1.0 for CD. The highest age-specific incidence rates were between 30 and 39 years for UC and between 20 and 29 years for CD. CONCLUSIONS: The incidence rate of CD in italy is homogeneous between the cities investigated and lower than those reported for other Mediterranean countries. In contrast, the UC incidence rate is within the range of those reported in European studies. A wide variability in the UC rates between the cities was also observed. These results could be related to different environmental factors or the genetic background of the populations, or both

Published
1996

8. Predicting mortality in non-variceal upper gastrointestinal bleeders: validation of the Italian PNED Score and Prospective Comparison with the Rockall Score

Author

Marmo, R, Koch, M, Cipolletta, L, Capurso, L, Grossi, E, Cestari, Renzo, Bianco, Ma, Pandolfo, N, Dezi, A, Casetti, T, Lorenzini, I, Germani, U, Imperiali, G, Stroppa, I, Barberani, F, Boschetto, S, Gigliozzi, A, Gatto, G, Peri, V, Buzzi, A, Della Casa, D, Di Cicco, M, Proietti, M, Aragona, G, Giangregorio, F, Allegretta, L, Tronci, S, Michetti, P, Romagnoli, P, Piubello, W, Ferri, B, Fornari, F, Del Piano, M, Pagliarulo, M, Di Mitri, R, Trallori, G, Bagnoli, S, Frosini, G, Macchiarelli, R, Sorrentini, I, Pietrini, L, De Stefano, S, Ceglia, T, Chiozzini, G, Salvagnini, M, Di Muzio, D, Rotondano, G, and Italian registry on upper gastrointestinal bleeding

Subjects
Male, medicine.medical_specialty, Validation study, Upper Gastrointestinal Tract, Internal medicine, Epidemiology, 80 and over, medicine, Upper gastrointestinal, Humans, Aged, Aged, 80 and over, Settore MED/12 - Gastroenterologia, Prognosis, Gastrointestinal Hemorrhage, Middle Aged, Female, Hepatology, business.industry, Gastroenterology, Surgery, Multicenter study, Varices, business, Rockall score, Venous disease
Abstract

We sought (i) to validate a new prediction rule of mortality (Progetto Nazionale Emorragia Digestiva (PNED) score) on an independent population with non-variceal upper gastrointestinal bleeding (UGIB) and (ii) to compare the accuracy of the Italian PNED score vs. the Rockall score in predicting the risk of death.We conducted prospective validation of analysis of consecutive patients with UGIB at 21 hospitals from 2007 to 2008. Outcome measure was 30-day mortality. All the variables used to calculate the Rockall score as well as those identified in the Italian predictive model were considered. Calibration of the model was tested using the chi2 goodness-of-fit and performance characteristics with receiver operating characteristic (ROC) analysis. The area under the ROC curve (AUC) was used to quantify the diagnostic accuracy of the two predictive models.Over a 16-month period, data on 1,360 patients were entered in a national database and analyzed. Peptic ulcer bleeding was recorded in 60.7% of cases. One or more comorbidities were present in 66% of patients. Endoscopic treatment was delivered in all high-risk patients followed by high-dose intravenous proton pump inhibitor in 95% of them. Sixty-six patients died (mortality 4.85%; 3.54-5.75). The PNED score showed a high discriminant capability and was significantly superior to the Rockall score in predicting the risk of death (AUC 0.81 (0.72-0.90) vs. 0.66 (0.60-0.72), P0.000). Positive likelihood ratio for mortality in patients with a PNED risk score8 was 16.05.The Italian 10-point score for the prediction of death was successfully validated in this independent population of patients with non-variceal gastrointestinal bleeding. The PNED score is accurate and superior to the Rockall score. Further external validation at the international level is needed.

Published
2010

10. Randomised clinical trial: low-volume bowel preparation for colonoscopy - a comparison between two different PEG-based formulations

Author

Repici, A, Cestari, R, Annese, V, Biscaglia, G, Vitetta, E, Minelli, Lorenza, Trallori, G, Orselli, S, Andriulli, A, Hassan, Cesare, Repici, A, Cestari, R, Annese, V, Biscaglia, G, Vitetta, E, Minelli, Lorenza, Trallori, G, Orselli, S, Andriulli, A, and Hassan, Cesare

Abstract

Low-volume bowel preparations with polyethylene glycol (PEG) have been shown to provide an equivalent cleansing with improved tolerability as compared with standard PEG bowel preparation for colonoscopy. A new iso-osmotic sulphate-free formulation of PEG-Citrate-Simethicone (PEG-CS) in combination with bisacodyl has been recently developed.

Published
2012

11. Disease history in 382 Italian patients with Crohn's disease

Author

Vannozzi G, Fontana R, Milla M, Ag, Bonanomi, Trallori G, Gabbrielli M, Pacini F, Gioacchino Leandro, and Morettini A

Subjects
Adult, Aged, 80 and over, Male, Reoperation, Adolescent, Incidence, Middle Aged, Cohort Studies, Survival Rate, Age Distribution, Crohn Disease, Italy, Recurrence, Risk Factors, Cause of Death, Humans, Female, Sex Distribution, Child, Aged, Follow-Up Studies, Retrospective Studies
Abstract

This large-scale study was aimed at evaluating the long-term history of Crohn's disease in a cohort of consecutive patients referred to the Careggi Hospital in Florence from January 1973 to June 1996.A total of 382 patients (187 females, 195 males; mean age of 47 years) were included in our study. The median follow-up was more than 11 years and only 46 patients (12%) had a follow-up of less than 1 year. The main endpoints evaluated in these patients included mortality for any cause, disease-specific mortality, recurrences, and need for surgery. Furthermore, in a subgroup of 130 patients observed during the last 6 months of our study, a more detailed assessment of the disease was carried out in which the distribution of inflammatory, fibrostenosing and fistulizing forms was determined.Our results showed that the disease-specific mortality rate was extremely low (around 3% at 10 years and 5% at 20 years), but the rate of recurrence was approximately 50% at 3 years and more than 60% at 6 years. Surgery was needed in more than 50% of the patients over the 10 years following diagnosis, and the risk of a second operation was of a further 30% within 4 years of the first operation.These epidemiological data emerging from our study are interesting since a large patient population was evaluated and the duration of the follow-up is extremely long.

Published
1998

12. Susceptibility to refractory ulcerative colitis is associated with polymorphism in the hMLH1 mismatch repair gene

Author

Bagnoli, S, Putignano, A, Melean, G, Baglioni, S, Sestini, R, Milla, M, D'Albasio, G, Genuardi, Maurizio, Pacini, F, Trallori, G, Papi, L, Genuardi, M (ORCID:0000-0002-7410-8351), Bagnoli, S, Putignano, A, Melean, G, Baglioni, S, Sestini, R, Milla, M, D'Albasio, G, Genuardi, Maurizio, Pacini, F, Trallori, G, Papi, L, and Genuardi, M (ORCID:0000-0002-7410-8351)

Abstract

The hMLH1 gene lies in the linkage susceptibility region to inflammatory bowel disease (IBD) on 3p21. A single nucleotide polymorphism, 655A>G, in exon 8 of the gene causes an 1219V change in the MLH1 protein. To test whether hMLH1 may confer susceptibility to ulcerative colitis (UC), we investigated an association between the 655A>G polymorphism and the disease. DNA-based technologies were used to analyze the 655A>G polymorphism in 201 UC patients and 126 healthy ethnically matched controls. The comparison of the allelic frequencies of the 655A>G polymorphism in UC patients and healthy controls did not show significant differences. However, genotype frequencies at the hMLH1 655 position were found to be significantly different when patients with and without refractory UC were compared. This was mainly attributable to a higher level of homozygosity for the G allele in refractory UC patients. Almost 5 times as many (4.9 times) refractory UC patients carried the GG genotype compared with nonrefractory patients (P < 0.0001). The present study provides evidence that the hMLH1 gene is involved in genetic susceptibility to refractory UC. If confirmed by other studies, the GG genotype at position 655 of the hMLH1 gene may represent a useful predictive factor for the clinical management of UC patients.

Published
2004

13. The role of quality of care in health-related quality of life in patients with IBD

Author

van der Eijk, Ingrid, Vlachonikolis, Iaonnis G., Munkholm, Pia, Nijman, Judy, Bernklev, Tomm, Politi, Patrizia, Odes, Selwyn, Tsianos, Epameinondas V., Stockbrügger, Reinhold W., Russel, Maurice G., Binder, V., Langholz, E., Vatn, M., Moum, B., Bernklev, T., Engdahl, I., O'Morain, C., Buckley, M., Stockbrügger, R., Russel, M., van der Eijk, I., Monteiro, E., Freitas, J., Tavarela Veloso, F., Fornaciari, G., Beltrami, M., Bodini, P., Politi, P., Bianchi, P., d'Albasio, G., Trallori, G., Cottone, M., Lupinacci, G., Mouzas, Y., Vlachonikolis, I., Tsianos, E., Katsanos, K., Odes, S., van der Eijk, Ingrid, Vlachonikolis, Iaonnis G., Munkholm, Pia, Nijman, Judy, Bernklev, Tomm, Politi, Patrizia, Odes, Selwyn, Tsianos, Epameinondas V., Stockbrügger, Reinhold W., Russel, Maurice G., Binder, V., Langholz, E., Vatn, M., Moum, B., Bernklev, T., Engdahl, I., O'Morain, C., Buckley, M., Stockbrügger, R., Russel, M., van der Eijk, I., Monteiro, E., Freitas, J., Tavarela Veloso, F., Fornaciari, G., Beltrami, M., Bodini, P., Politi, P., Bianchi, P., d'Albasio, G., Trallori, G., Cottone, M., Lupinacci, G., Mouzas, Y., Vlachonikolis, I., Tsianos, E., Katsanos, K., and Odes, S.

Abstract

In the literature there are indications of associations between health-related quality of life (HRQoL) in inflammatory bowel disease and disease activity, psychological status, coping, stressful life events, and social support. The aim of this study was to examine whether a relation exists between quality of health care and HRQoL, taking possible confounding variables into account. For this purpose, one single questionnaire was compiled from existing validated questionnaires. A population-based inception cohort of 1056 patients with inflammatory bowel disease in eight countries, diagnosed 6 to 8 years prior to the study, was approached to participate. In total, 824 patients responded (78%), and 517 could be included in statistical analyses. It was shown that in inflammatory bowel disease HRQoL was indeed influenced by quality of care (particularly with regard to the parameters of "providing information," " costs," and "courtesy"), as well as by disease activity, psychological status, type of hospital, social support, stressful life events, and way of administration of the questionnaire. Patients with active disease had lower psychological status and HRQoL scores at the time of the survey than patients without active disease. However, quality of care scores did not differ between these groups. The care aspect "costs" was scored worse by CD compared with UC patients, probably caused by a potentially more expensive treatment. In conclusion, it is shown in a large exploratory study, for the first time, that in inflammatory bowel disease, quality of care has a significant role in determining health-related quality of life.

Published
2004

14. Heterogeneous expression of cyclooxygenase-2 and inducible nitric oxide synthase within colorectal tumors: Correlation with tumor angiogenesis

Author

Cianchi, F., primary, Cuzzocrea, S., additional, Vinci, M.C., additional, Messerini, L., additional, Comin, C.E., additional, Navarra, G., additional, Perigli, G., additional, Centorrino, T., additional, Marzocco, S., additional, Lenzi, E., additional, Battisti, N., additional, Trallori, G., additional, and Masini, E., additional

Published
2010
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16. PREDICTIVE FACTORS OF MORTALITY IN UPPER NONVARICEAL GI BLEEDING: VALIDATION OF A NEW PROGNOSTIC MODEL FROM A MULTICENTER ITALIAN STUDY

Author

Marmo, R., primary, Rotondano, G., additional, Koch, M., additional, Cipolletta, L., additional, Capurso, L., additional, Trallori, G., additional, Cestari, R., additional, Frosini, G., additional, Imperiali, G., additional, Casetti, T., additional, Boschetto, S., additional, DiMitri, S., additional, Stroppa, I., additional, DelPiano, M., additional, Salvagnini, M., additional, Gatto, G., additional, Sorrentini, I., additional, DeStefano, S., additional, Di Cicco, M., additional, Michetti, P., additional, Lorenzini, I., additional, Fornari, F., additional, Piubello, W., additional, Dezi, A., additional, Milla, M., additional, Bianco, M.A., additional, Della Casa, N., additional, Longobardi, G., additional, Triossi, O., additional, Gigliozzi, A., additional, Carmagnola, S., additional, DiMuzio, D., additional, Marino, M., additional, Russo, F., additional, Lamanda, R., additional, Proietti, M., additional, Allegretti, A., additional, Germani, U., additional, Giangregorio, F., additional, Zagni, I., additional, and Grossi, E., additional

Published
2009
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17. PREDICTION OF MORTALITY FROM UPPER GASTRO-INTESTINAL BLEEDING: COMPARISON OF ROCKALL SCORE VS THE ITALIAN PNED SCORE

Author

Marmo, R., primary, Rotondano, G., additional, Koch, M., additional, Cipolletta, L., additional, Capurso, L., additional, Trallori, G., additional, Cestari, R., additional, Frosini, G., additional, Imperiali, G., additional, Casetti, T., additional, Boschetto, S., additional, Di Mitri, R., additional, Stroppa, I., additional, Del Piano, M., additional, Salvagnini, M., additional, Gatto, G., additional, Sorrentini, I., additional, De Stefano, S., additional, Di Cicco, M., additional, Michetti, P., additional, Lorenzini, I., additional, Fornari, F., additional, Piubello, W., additional, Dezi, A., additional, Bagnoli, S., additional, Bianco, M.A., additional, Della Casa, N., additional, Macchiarelli, R., additional, Buzzi, A., additional, Gigliozzi, A., additional, Pagliarulo, M., additional, Di Muzio, D., additional, Peri, V., additional, Pietrini, L., additional, Ceglia, T., additional, Proietti, M., additional, Romagnoli, P., additional, Germani, U., additional, Aragona, G., additional, Ferri, B., additional, and Grossi, E., additional

Published
2009
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19. Risk of inflammatory bowel disease attributable to smoking, oral contraception and breastfeeding in Italy: A nationwide case-control study

Author

Corrao, G, Tragnone, A, Caprilli, R, Trallori, G, Papi, C, Andreoli, A, Di Paolo, M, Riegler, G, Rigo, G, Ferraù, O, Mansi, C, Ingrosso, M, Valpiani, D, CORRAO, GIOVANNI, Rigo, GP, Valpiani, D., Corrao, G, Tragnone, A, Caprilli, R, Trallori, G, Papi, C, Andreoli, A, Di Paolo, M, Riegler, G, Rigo, G, Ferraù, O, Mansi, C, Ingrosso, M, Valpiani, D, CORRAO, GIOVANNI, Rigo, GP, and Valpiani, D.

Abstract

BACKGROUND: Using data from a case-control study carried out in Italy 1989-1992, we estimated the odds ratios (OR) and the population attributable risks (AR) for inflammatory bowel diseases (IBD) in relation to smoking, oral contraception and breastfeeding in infancy. METHODS: The study focused on 819 cases of IBD (594 ulcerative colitis: UC; 225 Crohn's disease: CD) originating from populations resident in 10 Italian areas, and age-sex matched paired controls. RESULTS: Compared with non-smokers, former smokers were at increased risk of UC (OR = 3.0; 95% confidence interval [CI]: 2.1-4.3), whereas current smokers were at increased risk of CD (OR = 1.7; 95% CI: 1.1-2.6). Females who reported use of oral contraceptives for at least one month before onset of symptoms had a higher risk of CD (OR = 3.4; 95% CI: 1.0-11.9), whereas no significant risk was observed for UC. Lack of breastfeeding was associated with an increased risk of UC (OR = 1.5; 95% CI: 1.1-2.1) and CD (OR = 1.9; 95% CI: 1.1-3.3). Being a 'former smoker' was the factor with the highest attributable risk of UC both in males (AR = 28%; 95% CI: 20-35 %) and in females (AR = 12%; 95% CI: 5-18%). Smoking was the factor with the highest attributable risk for CD in males (AR = 31%; 95% CI: 11-50%). Lack of breastfeeding accounted for the highest proportion of CD in females (AR = 11%; 95% CI: 1-22%). Oral contraceptive use accounted for 7% of cases of UC and for 11% of cases of CD. CONCLUSIONS: Taken together, the considered factors were responsible for a proportion of IBD ranging from 26% (CD females) to 36% (CD males). It is concluded that other environmental and genetic factors may be involved in the aetiology of IBD

Published
1998

23. DNA aneuploidy in long-standing ulcerative colitis

Author

D'Albasio, G., primary, Bagnoli, S., additional, Bonanomi, A.G., additional, Mallardi, B., additional, Milla, M., additional, Tarantino, O., additional, Trallori, G., additional, Vannozzi, G., additional, Amorosi, A., additional, Caldini, A., additional, and Pacini, F., additional

Published
2000
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28. A Population-Based Study of Inflammatory Bowel Disease in Florence over 15 Years (1978-92)

Author

Trallori, G., primary, Palli, D., additional, Saieva, C., additional, Bardazzi, G., additional, Bonanomi, A. G., additional, D'albasio, G., additional, Galli, M., additional, Vannozzi, G., additional, Milla, M., additional, Tarantino, O., additional, Renai, F., additional, Messori, A., additional, Amorosi, A., additional, Pacini, F., additional, and Morettini, A., additional

Published
1996
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32. Fecal levels of short-chain fatty acids and bile acids as determinants of colonic mucosal cell proliferation in humans.

Author

Dolara P, Caderni G, Salvadori M, Morozzi G, Fabiani R, Cresci A, Orpianesi C, Trallori G, Russo A, and Palli D

Abstract

We studied the correlation between fecal levels of short-chain fatty acids (SCFA), bile acids (BA), and colonic mucosal proliferation in humans on a free diet. Subjects [n = 43: 27 men and 16 women; 61 +/- 7 and 59 +/- 6 (SE) yr old, respectively] were outpatients who previously underwent resection of at least two sporadic colon polyps. Mucosal proliferation was determined by [3H]thymidine incorporation in vitro in three colorectal biopsies obtained without cathartics and was expressed as labeling index (LI). BA were analyzed in feces by mass spectrometry and SCFA by gas chromatography. We found that increasing levels of BA in feces did not correlate with higher LI. On the contrary, higher levels of SCFA were significantly associated with lower LI in the colonic mucosa (P for trend = 0.02). In conclusion, in humans on a free diet, intestinal proliferation seems to be regulated by the levels of SCFA in feces and not by BA. Because a lower intestinal proliferation is associated with a decreased colon cancer risk, treatments or diets that increase colonic levels of SCFA might be beneficial for colonic mucosa. [ABSTRACT FROM AUTHOR]

Published
2002
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34. Combined Therapy with 5-Aminosalicylic Acid Tablets and Enemas for Maintaining Remission in Ulcerative Colitis: A Randomized Double-Blind Study.

Author

D'Albasio, G., Pacini, F., Camarri, E., Messori, A., Trallori, G., Bonanomi, A. G., Bardazzi, G., Milla, M., Ferrero, S., Biagini, M., Quaranta, S., and Amorosi, A.

Subjects
ULCERATIVE colitis, COLITIS, COLON diseases, THERAPEUTICS, CLINICAL trials
Abstract

Objectives: To assess the efficacy of a combination of oral and topical 5-aminosalicylic acid (5-ASA) for the maintenance treatment of ulcerative colitis, we under-took a double-blind randomized clinical trial. Methods: Patients aged 18 to 65 yr (with disease extent greater than proctitis only) were eligible for inclusion in the study if they met the following criteria: (a) history of two or more relapses in the last year; (b) achievement of remission in the last 3 months (with maintenance of remission for at least 1 month). Patients enrolled in the study were randomly assigned to one of the two following 1-yr treatments: (1) combined therapy with 5-ASA tablets 1.6 g/day and 5-ASA enemas 4 g/100 ml twice weekly; (2) oral therapy with 5-ASA tablets 1.6 g/day and placebo enemas/twice weekly. The main end point of the study was the maintenance of remission at 12 months. Results: Upon completion of the study, relapse ocurred in 13 of 33 patients in the combined treatment group versus 23 of 36 patients in the oral treatment group (39 vs 69%; p = 0.036). No significant side effects related to treatment were observed in either group. A simplified pharmacoeconomic analysis shows that this form of combined treatment can have a favorable cost-effectiveness ratio. Conclusions: Our results indicate that 5-ASA given daily by oral route and intermittently by topical route can be more effective than oral therapy alone. This form of combination treatment can be appropriate for patients at high risk of relapse. [ABSTRACT FROM AUTHOR]

Published
1997

35. Risk of inflammatory bowel disease attributable to smoking, oral contraception and breastfeeding in Italy: a nationwide case-control study. Cooperative Investigators of the Italian Group for the Study of the Colon and the Rectum (GISC).

Author

Corrao, G, Tragnone, A, Caprilli, R, Trallori, G, Papi, C, Andreoli, A, Di Paolo, M, Riegler, G, Rigo, GP, Ferraù, O, Mansi, C, Ingrosso, M, Valpiani, D, Investigators of the Italian Group for the Study of the Colon, Cooperative, Rectum (GISC), the, and Rigo, G P

Abstract

Background: Using data from a case-control study carried out in Italy 1989-1992, we estimated the odds ratios (OR) and the population attributable risks (AR) for inflammatory bowel diseases (IBD) in relation to smoking, oral contraception and breastfeeding in infancy.Methods: The study focused on 819 cases of IBD (594 ulcerative colitis: UC; 225 Crohn's disease: CD) originating from populations resident in 10 Italian areas, and age-sex matched paired controls.Results: Compared with non-smokers, former smokers were at increased risk of UC (OR = 3.0; 95% confidence interval [CI]: 2.1-4.3), whereas current smokers were at increased risk of CD (OR = 1.7; 95% CI: 1.1-2.6). Females who reported use of oral contraceptives for at least one month before onset of symptoms had a higher risk of CD (OR = 3.4; 95% CI: 1.0-11.9), whereas no significant risk was observed for UC. Lack of breastfeeding was associated with an increased risk of UC (OR = 1.5; 95% CI: 1.1-2.1) and CD (OR = 1.9; 95% CI: 1.1-3.3). Being a 'former smoker' was the factor with the highest attributable risk of UC both in males (AR = 28%; 95% CI: 20-35 %) and in females (AR = 12%; 95% CI: 5-18%). Smoking was the factor with the highest attributable risk for CD in males (AR = 31%; 95% CI: 11-50%). Lack of breastfeeding accounted for the highest proportion of CD in females (AR = 11%; 95% CI: 1-22%). Oral contraceptive use accounted for 7% of cases of UC and for 11% of cases of CD.Conclusions: Taken together, the considered factors were responsible for a proportion of IBD ranging from 26% (CD females) to 36% (CD males). It is concluded that other environmental and genetic factors may be involved in the aetiology of IBD. [ABSTRACT FROM AUTHOR]

Published
1998
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42. 5Aminosalicylic Acid Enemas to Maintain Remission in LeftSided Ulcerative Colitis

Author

Trallori, G., Messori, A., Scuffi, C., Bardazzi, G., Silvano, R., d'Albasio, G., and Pacini, F.

Abstract

The efficacy of 5-aminosalicylic acid (5-ASA) enemas for maintaining remission in left-sided ulcerative colitis is controversial because clinical trials conducted thus far have given conflicting results (1–7). To further investigate this issue, we undertook a meta-analysis of the published studies.

Published
1995

44. Robotic rectal surgery: State of the art.

Author

Staderini F, Foppa C, Minuzzo A, Badii B, Qirici E, Trallori G, Mallardi B, Lami G, Macrì G, Bonanomi A, Bagnoli S, Perigli G, and Cianchi F

Abstract

Laparoscopic rectal surgery has demonstrated its superiority over the open approach, however it still has some technical limitations that lead to the development of robotic platforms. Nevertheless the literature on this topic is rapidly expanding there is still no consensus about benefits of robotic rectal cancer surgery over the laparoscopic one. For this reason a review of all the literature examining robotic surgery for rectal cancer was performed. Two reviewers independently conducted a search of electronic databases (PubMed and EMBASE) using the key words "rectum", "rectal", "cancer", "laparoscopy", "robot". After the initial screen of 266 articles, 43 papers were selected for review. A total of 3013 patients were included in the review. The most commonly performed intervention was low anterior resection (1450 patients, 48.1%), followed by anterior resections (997 patients, 33%), ultra-low anterior resections (393 patients, 13%) and abdominoperineal resections (173 patients, 5.7%). Robotic rectal surgery seems to offer potential advantages especially in low anterior resections with lower conversions rates and better preservation of the autonomic function. Quality of mesorectum and status of and circumferential resection margins are similar to those obtained with conventional laparoscopy even if robotic rectal surgery is undoubtedly associated with longer operative times. This review demonstrated that robotic rectal surgery is both safe and feasible but there is no evidence of its superiority over laparoscopy in terms of postoperative, clinical outcomes and incidence of complications. In conclusion robotic rectal surgery seems to overcome some of technical limitations of conventional laparoscopic surgery especially for tumors requiring low and ultra-low anterior resections but this technical improvement seems not to provide, until now, any significant clinical advantages to the patients., Competing Interests: Conflict-of-interest statement: Authors declare no conflict of interest for this article. Authors declare no instance of Plagiarism or Academic Misconduct.

Published
2016
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45. Robotic vs laparoscopic distal gastrectomy with D2 lymphadenectomy for gastric cancer: a retrospective comparative mono-institutional study.

Author

Cianchi F, Indennitate G, Trallori G, Ortolani M, Paoli B, Macrì G, Lami G, Mallardi B, Badii B, Staderini F, Qirici E, Taddei A, Ringressi MN, Messerini L, Novelli L, Bagnoli S, Bonanomi A, Foppa C, Skalamera I, Fiorenza G, and Perigli G

Subjects
Adult, Aged, Aged, 80 and over, Chi-Square Distribution, Female, Humans, Male, Middle Aged, Operative Time, Retrospective Studies, Treatment Outcome, Gastrectomy methods, Laparoscopy, Lymph Node Excision, Robotic Surgical Procedures, Stomach Neoplasms surgery
Abstract

Background: Robotic surgery has been developed with the aim of improving surgical quality and overcoming the limitations of conventional laparoscopy in the performance of complex mini-invasive procedures. The present study was designed to compare robotic and laparoscopic distal gastrectomy in the treatment of gastric cancer., Methods: Between June 2008 and September 2015, 41 laparoscopic and 30 robotic distal gastrectomies were performed by a single surgeon at the same institution. Clinicopathological characteristics of the patients, surgical performance, postoperative morbidity/mortality and pathologic data were prospectively collected and compared between the laparoscopic and robotic groups by the Chi-square test and the Mann-Whitney test, as indicated., Results: There were no significant differences in patient characteristics between the two groups. Mean tumor size was larger in the laparoscopic than in the robotic patients (5.3 ± 0.5 cm and 3.0 ± 0.4 cm, respectively; P = 0.02). However, tumor stage distribution was similar between the two groups. The mean number of dissected lymph nodes was higher in the robotic than in the laparoscopic patients (39.1 ± 3.7 and 30.5 ± 2.0, respectively; P = 0.02). The mean operative time was 262.6 ± 8.6 min in the laparoscopic group and 312.6 ± 15.7 min in the robotic group (P < 0.001). The incidences of surgery-related and surgery-unrelated complications were similar in the laparoscopic and in the robotic patients. There were no significant differences in short-term clinical outcomes between the two groups., Conclusions: Within the limitation of a small-sized, non-randomized analysis, our study confirms that robotic distal gastrectomy is a feasible and safe surgical procedure. When compared with conventional laparoscopy, robotic surgery shows evident benefits in the performance of lymphadenectomy with a higher number of retrieved and examined lymph nodes.

Published
2016
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46. Survival after laparoscopic and open surgery for colon cancer: a comparative, single-institution study.

Author

Cianchi F, Trallori G, Mallardi B, Macrì G, Biagini MR, Lami G, Indennitate G, Bagnoli S, Bonanomi A, Messerini L, Badii B, Staderini F, Skalamera I, Fiorenza G, and Perigli G

Subjects
Adenocarcinoma mortality, Adult, Aged, Aged, 80 and over, Colonic Neoplasms mortality, Female, Follow-Up Studies, Humans, Male, Middle Aged, Retrospective Studies, Survival Analysis, Treatment Outcome, Adenocarcinoma surgery, Colectomy methods, Colonic Neoplasms surgery, Laparoscopy
Abstract

Background: Some recent studies have suggested that laparoscopic surgery for colorectal cancer may provide a potential survival advantage when compared with open surgery. This study aimed to compare cancer-related survivals of patients who underwent laparoscopic or open resection of colon cancer in the same, high volume tertiary center., Methods: Patients who had undergone elective open or laparoscopic surgery for colon cancer between January 2002 and December 2010 were analyzed. A clinical database was prospectively compiled. Survival analysis was calculated by using the Kaplan-Meier method., Results: A total of 460 resections were performed. There were no significant differences between the laparoscopic (n = 227) and the open group (n = 233) apart from tumor stage: stage I tumors were more frequent in the laparoscopic group whereas stage II tumors were more frequent in the open group. The mean number of harvested lymph nodes was significantly higher in the laparoscopic than in the open group (20.0 ± 0.7 vs 14.2 ± 0.5, P < 0.01). The 5-year cancer-related survival for patients undergoing laparoscopic resection was significantly higher than that following open resections (83.1% vs 68.5%, P = 0.01). By performing a stage-to-stage comparison, we found that the improvement in survival in the laparoscopic group occurred mainly in patients with stage II tumors., Conclusions: Our study shows a survival advantage for patients who had undergone laparoscopic surgery for stage II colon cancer. This may be correlated with a higher number of harvested lymph nodes and thus a better stage stratification of these patients.

Published
2015
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47. Laparoscopic total gastrectomy using the transorally inserted anvil (OrVil™): a preliminary, single institution experience.

Author

Cianchi F, Macrì G, Indennitate G, Mallardi B, Trallori G, Biagini MR, Badii B, Staderini F, and Perigli G

Abstract

Laparoscopic total gastrectomy (LTG) is not a commonly performed procedure due to the difficulty associated with surgical reconstruction. We present our preliminary results after intracorporeal circular stapling esophagojejunostomy using the newly developed transorally inserted anvil (OrVil™, Covidien, MA, USA). Between 2008 and June 2013, 51 patients underwent laparoscopic gastrectomy with D2 lymph node dissection for gastric cancer. A total of 12 patients underwent LTG: of these, 5 received an intracorporeal linear side-to-side esophagojejunal anastomosis and the remaining 7 underwent intracorporeal circular stapling esophagojejunostomy using the OrVil™ system. Short-term outcomes were compared between the two groups. There were no intraoperative complications or conversions to open surgery in any patients. The mean operative time was significantly shorter in the OrVil™ than in the side-to-side group (261.4 ± 12.0 vs 333.0 ± 15.0 minutes, respectively, p = 0.005). Postoperative fluorography revealed no anastomosis leakage or stenosis in either groups. All patients resumed an oral liquid diet on postoperative day 5 and the mean postoperative hospital stay was 9 days. Intracorporeal circular stapling esophagojejunostomy using the OrVil™ system is technically feasible and safe in LTG. This technique may be considered a simple and time-saving alternative to the side-to-side linear esophagojejunostomy.

Published
2014
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48. Totally laparoscopic versus open gastrectomy for gastric cancer: a matched cohort study.

Author

Cianchi F, Qirici E, Trallori G, Macrì G, Indennitate G, Ortolani M, Paoli B, Biagini MR, Galli A, Messerini L, Mallardi B, Badii B, Staderini F, and Perigli G

Subjects
Adult, Aged, Aged, 80 and over, Cohort Studies, Female, Humans, Male, Middle Aged, Gastrectomy methods, Gastroscopy, Stomach Neoplasms surgery
Abstract

Background: The role of laparoscopic surgery for the treatment of gastric cancer is still controversial, particularly in terms of oncologic efficacy. The aim of this study was to compare short-term outcomes of laparoscopic and open resection for gastric cancer at a single Western institution., Subjects and Methods: This study was designed as a matched cohort study from a prospective gastric cancer database. Forty-one patients undergoing laparoscopic gastrectomy for gastric cancer between June 2008 and January 2012 were matched with 41 patients undergoing open gastrectomy in the same time period. Patient pairing was done according to age, gender, type of gastrectomy (subtotal or total), and tumor stage via a randomized statistical method. The short-term outcomes and oncologic adequacy of the laparoscopic and open procedures were compared. A D2 lymph node dissection was performed in the majority of patients in both groups., Results: The two study groups were similar with respect to patient and tumor characteristics. Laparoscopic procedures were associated with a decreased blood loss (118.7 versus 312.4 mL, P<.005), incidence of surgery-unrelated complications (3 versus 9 patients, P<.05), and duration of hospital stay (8.1 versus 11.5 days, P<.05) but increased operative time for both subtotal (223.5 versus 158.2 minutes, P<.001) and total (298.1 versus 185.5 minutes, P<.001) gastrectomies. The mean number of retrieved lymph nodes after D2 dissection was similar: 30.0 for laparoscopic and 29.7 for open patients., Conclusions: Within the limitations of a nonrandomized analysis, this study shows that the laparoscopic approach is a safe and oncologically adequate option for the treatment of gastric cancer, which compares favorably with open gastrectomy in short-term outcomes.

Published
2013
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49. Single-incision laparoscopic colectomy: technical aspects and short-term results.

Author

Cianchi F, Qirici E, Trallori G, Mallardi B, Badii B, and Perigli G

Subjects
Adult, Aged, Female, Humans, Male, Middle Aged, Postoperative Complications, Treatment Outcome, Colectomy methods, Colonic Diseases surgery, Laparoscopy methods
Abstract

Single-incision laparoscopic surgery (SILS) is currently regarded as the next major advance in the progress of minimally invasive techniques in colorectal surgery. We describe our initial experience using SILS for the management of colorectal disease and present preliminary short-term results. Between February 2010 and April 2011, 7 patients (4 females and 3 males, mean age 55 years, range 32–74) underwent SILS for either benign or malignant colorectal disease. Preoperative diagnosis was diverticular disease of the sigmoid colon in two patients, malignant polyps of the sigmoid colon in two other patients and large villous tumor of the right colon in three patients. Surgical procedures, 4 anterior resections of the rectum and 3 right hemicolectomies, were performed through a 3 cm single umbilical incision using a SILS multi port device with conventional or articulated laparoscopic instruments. There were no intraoperative complications or conversions in the standard laparoscopic procedure. The mean operative time for anterior resections was 160.0 ± 10.6 min, whereas it was 160.6 ± 20 for right hemicolectomies. Blood loss was minimal. No postoperative complications were reported in any of the patients. The overall mean hospital stay was 4.8 ± 0.2 days (range 4–5). For the subset of patients with malignant or pre-malignant disease, the mean number of retrieved lymph nodes was 15.6 ± 4.4 (range 6–31). Cosmetic results were considered excellent by all the patients after 15 days. In conclusion, our preliminary experience shows that SILS for colorectal disease is feasible and safe with potential reproducible oncologic results.

Published
2012
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50. Adequacy of lymphadenectomy in laparoscopic colorectal cancer surgery: a single-centre, retrospective study.

Author

Cianchi F, Cortesini C, Trallori G, Messerini L, Novelli L, Comin CE, Qirici E, Bonanomi A, Macrì G, Badii B, Kokomani A, and Perigli G

Subjects
Adult, Aged, Aged, 80 and over, Female, Humans, Lymphatic Metastasis, Male, Middle Aged, Retrospective Studies, Colectomy methods, Colonic Neoplasms surgery, Lymph Node Excision methods, Rectal Neoplasms surgery
Abstract

Purpose: This study aimed at evaluating the lymph node (LN) harvest after both open and laparoscopic colorectal cancer surgery., Methods: In the period between 1996 and 2009, 404 patients with colorectal cancer underwent open resection, whereas 147 patients underwent laparoscopic surgery., Results: The overall number of harvested LNs was significantly higher in the laparoscopic group than in the open one (16.5 vs. 14.3, P<0.001). A higher number of LNs was found in moderately differentiated tumors of the laparoscopic group when compared with the open surgery group (16.7 vs. 14.2, P<0.01). The numbers of harvested LNs in the proximal tumors and in stage II and III tumors were higher in the laparoscopic group than in the open group (18.9 vs. 15.4, P<0.001; 17.9 vs. 14.2, P=0.002; 17.3 vs. 15.3, P=0.02, respectively)., Conclusions: Laparoscopic surgery for colorectal cancer can achieve LN retrieval similar to that achieved by the open approach.

Published
2012
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