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1,143 results on '"Traeger J"'

1. PATHOLOGY OF RENAL ALLOGRAFTS IN PATIENTS RECEIVING LONG-TERM ANTILYMPHOCYTE GLOBULIN THERAPY

Author

Fries, D, Blano-Brunat, N, and Traeger, J

Abstract

The pathology of functioning renal allografts was studied in 24 patients followed for more than 3 months after surgery and continuously treated with antilymphocyte globulin (ALG). The type of renal lesions were similar in nature to those found in patients not given ALG, but the incidence of vascular and glomerular alterations is less. There is a relationship between histological changes in the kidneys and the degree of histocompatibility, suggesting that ALG treatment does not reduce the pathological feature when important histocompatibility differences exist between host and donor. The clinical status, improved by ALG, does not correlate with the pathological status, but good renal function is insensitive as an index of renal damage.

Published
2024

9. Role of sensory nerves in the cutaneous vasoconstrictor response to local cooling in humans

Author

Hodges, Gary J., Traeger, J. Andrew, III, Tang, Tri, Kosiba, Wojciech A., Zhao, Kun, and Johnson, John M.

Subjects
Vasoconstriction -- Research, Microcirculation -- Research, Adrenergic mechanisms -- Research, Bretylium tosylate -- Research, Cardiovascular research, Biological sciences
Abstract

Local cooling (LC) causes a cutaneous vasoconstriction (VC). In this study, we tested whether there is a mechanism that links LC to VC nerve function via sensory nerves. Six subjects participated. Local skin and body temperatures were controlled with Peltier probe holders and water-perfused suits, respectively. Skin blood flow at four forearm sites was monitored by laser-Doppler flowmetry with the following treatments: untreated control, pretreatment with local anesthesia (LA) blocking sensory nerve function, pretreatment with bretylium tosylate (BT) blocking VC nerve function, and pretreatment with both LA and BT. Local skin temperature was slowly reduced from 34 to 29[degrees]C at all four sites. Both sites treated with LA produced an increase in cutaneous vascular conductance (CVC) early in the LC process (64 [+ or -] 55%, LA only; 42 [+ or -] 14% LA plus BT; P < 0.05), which was absent at the control and BT-only sites (5 [+ or -] 8 and 6 [+ or -] 8%, respectively; P > 0.05). As cooling continued, there were significant reductions in CVC at all sites (P < 0.05). At control and LA-only sites, CVC decreased by 39 [+ or -] 4 and 46 [+ or -] 8% of the original baseline values, which were significantly (P < 0.05) more than the reductions in CVC at the sites treated with BT and BT plus LA (-26 [+ or -] 8 and -22 [+ or -] 6%). Because LA affected only the short-term response to LC, either alone or in the presence of BT, we conclude that sensory nerves are involved early in the VC response to LC, but not for either adrenergic or nonadrenergic VC with longer term LC. cutaneous circulation; adrenergic; bretylium; local anesthesia doi:10.1152/ajpregu.00323.2007

Published
2007

11. Out-center Dialysis and Renal Transplantation

Author

Delawari, E., Laville, M., Arkouche, W., Abdullah, E., Sibai, R., Traeger, J., Touraine, J. L., editor, Traeger, J., editor, Bétuel, H., editor, Dubernard, J. M., editor, Revillard, J. P., editor, and Dupuy, C., editor

Published
1995
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25. Changes Induced by Orthostatism in Plasma Renin Activity and Natriuresis

Author

N. Pozet, P. Zech, A. Hadj Aissa, Traeger J, Madeleine Vincent, and M. Labeeuw

Subjects
medicine.medical_specialty, Creatinine, business.industry, Renal function, Plasma renin activity, Natriuresis, chemistry.chemical_compound, Blood pressure, Endocrinology, chemistry, Internal medicine, Renin–angiotensin system, Heart rate, medicine, business
Published
2015

41. Trace Proteinuria

Author

Manuel, Y., primary, Revillard, J. P., additional, Fran�ois, R., additional, Traeger, J., additional, Gaillard, L., additional, Salle, B., additional, Freycon, M. T., additional, and Borenstain, I., additional

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42. ENDOCRINOMETABOLIC EFFECTS OF WHOLE VERSUS SEGMENTAL PANCREAS ALLOTRANSPLANTATION IN DIABETIC-PATIENTS - A 2-YEAR FOLLOW-UP

Author

SECCHI , ANTONIO, DUBERNARD JM, LAROCCA E, LEFRANCOIS N, MELANDRI M, MARTIN X, TOURAINE JL, TRAEGER J, POZZA G., Secchi, Antonio, Dubernard, Jm, Larocca, E, Lefrancois, N, Melandri, M, Martin, X, Touraine, Jl, Traeger, J, and Pozza, G.

Abstract

We have investigated the metabolic effects of segmental (neoprene-injected) pancreas transplantation versus whole (enteric-diverted) pancreas transplantation. Seventeen uremic insulin-dependent diabetes mellitus (IDDM) patients received a simultaneous pancreaticorenal transplant: in a prospective, randomized study, 9 patients received a segmental neoprene-injected graft (group A) while 8 patients received a total pancreatico-duodenal graft, with enteric diversion (group B). The immunosuppressive therapy was based on ALG, CsA, azathioprine, and steroids. Three months after surgery, patients were submitted to the following metabolic investigation: i.v. and oral glucose tolerance tests, Hba 1, i.v. arginine test, and a 24-hr metabolic profile. The OGTT, HbA1, and metabolic profile were repeated 12 and 24 months after transplantation. At 3 months after transplantation, the OGTT showed delayed insulin secretion and higher blood glucose levels in group A. Serum insulin levels after IVGTT or arginine were higher in group B than in group A. OGTT at 12 and 24 months were unchanged in group B, while in group A a higher incidence of impaired glucose tolerance (IGT) and diabetes mellitus response were observed. HbA1 and blood glucose levels during the 24-hr profile showed good metabolic control in both groups at 3, 12, and 24 months. We can conclude that both the segmental and total pancreas transplantation restore a good metabolic control in IDDM patients, though a higher incidence of IGT and DM responses were observed after OGTT in the patients receiving a segmental graft. These abnormalities do not seem to interfere with metabolic control in everyday life. These results seem to be the consequence of the different B cell masses transplanted with these two techniques.

Published
1991

45. Late Graft Loss

Author

Jean-Louis Touraine, C. Dupuy, Betuel H, Revillard Jp, J. M. Dubernard, and Traeger J

Subjects
medicine.medical_specialty, business.industry, medicine, Graft loss, business, Surgery
Published
1997

46. Cancer in Transplantation: Prevention and Treatment

Author

H. Bétuel, Traeger J, J. L. Touraine, C. Dupuy, J. M. Dubernard, and Revillard Jp

Subjects
Oncology, Transplantation, medicine.medical_specialty, business.industry, Internal medicine, medicine, Cancer, business, medicine.disease
Published
1996

48. Organ Shortage: The Solutions

Author

Traeger J, H. Bétuel, J. L. Touraine, C. Dupuy, J. M. Dubernard, and Revillard Jp

Subjects
business.industry, Natural resource economics, Medicine, Economic shortage, business
Published
1995

49. Rejection and Tolerance

Author

Revillard Jp, J. L. Touraine, Traeger J, Betuel H, Jean-Michel Dubernard, and C. Dupuy

Subjects
business.industry, Medicine, business
Published
1994

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