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3 results on '"Tracy Willson"'

1. BAF complex-mediated chromatin relaxation is required for establishment of X chromosome inactivation

Author

Andrew Keniry, Natasha Jansz, Linden J. Gearing, Iromi Wanigasuriya, Joseph Chen, Christian M. Nefzger, Peter F. Hickey, Quentin Gouil, Joy Liu, Kelsey A. Breslin, Megan Iminitoff, Tamara Beck, Andres Tapia del Fierro, Lachlan Whitehead, Andrew Jarratt, Sarah A. Kinkel, Phillippa C. Taberlay, Tracy Willson, Miha Pakusch, Matthew E. Ritchie, Douglas J. Hilton, Jose M. Polo, and Marnie E. Blewitt

Subjects
Science
Abstract

Female embryonic stem cells (ESCs) are the ideal model to study X chromosome inactivation (XCI) establishment; however, these cells are challenging to keep in culture. Here the authors create fluorescent ‘Xmas’ reporter mice as a renewable source of ESCs and show nucleosome remodelers Smarcc1 and Smarca4 create a nucleosome-free promoter region prior to the establishment of silencing.

Published
2022
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2. An Erg-driven transcriptional program controls B cell lymphopoiesis

Author

Ashley P. Ng, Hannah D. Coughlan, Soroor Hediyeh-zadeh, Kira Behrens, Timothy M. Johanson, Michael Sze Yuan Low, Charles C. Bell, Omer Gilan, Yih-Chih Chan, Andrew J. Kueh, Thomas Boudier, Rebecca Feltham, Anna Gabrielyan, Ladina DiRago, Craig D. Hyland, Helen Ierino, Sandra Mifsud, Elizabeth Viney, Tracy Willson, Mark A. Dawson, Rhys S. Allan, Marco J. Herold, Kelly Rogers, David M. Tarlinton, Gordon K. Smyth, Melissa J. Davis, Stephen L. Nutt, and Warren S. Alexander

Subjects
Science
Abstract

B cell development is tightly regulated in a stepwise manner to ensure proper generation of repertoire diversity via somatic gene rearrangements. Here, the authors show that a transcription factor, Erg, functions at the earliest stage to critically control two downstream factors, Ebf1 and Pax5, for modulating this gene rearrangement process.

Published
2020
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3. 3104 – CLONAL MULTI-OMICS METHODS SIS-SEQ AND SIS-SKEW REVEAL BCOR AS A NEGATIVE REGULATOR OF EMERGENCY DENDRITIC CELL DEVELOPMENT

Author

Shalin Naik, Luyi Tian, Sara Tomei, Jaring Schreuder, Tom Weber, Daniela Amman-Zalcenstein, Dawn Lin, Jessica Tran, Cindy Audiger, Melanie Bahlo, Mathew Chu, Peter Diakumis, Quentin Gouil, Adrienne Hilton, Andrew Jarratt, Tracy Willson, Lev Kats, Madison kelly, Ee Shan Pang, Meredith O'Keeffe, Timothy Patton, Tobias Sargeant, Shian Su, Philip Hodgkin, Ashley Ng, and Matthew Ritchie

Subjects
Cancer Research, Genetics, Cell Biology, Hematology, Molecular Biology
Published
2021
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