Search

Rapid antigen tests, such as the Abbott BinaxNOW COVID-19 Ag Card (BinaxNOW), offer results more rapidly (approximately 15-30 minutes) and at a lower cost than do highly sensitive nucleic acid amplification tests (NAATs) (1). Rapid antigen tests have received Food and Drug Administration (FDA) Emergency Use Authorization (EUA) for use in symptomatic persons (2), but data are lacking on test performance in asymptomatic persons to inform expanded screening testing to rapidly identify and isolate infected persons (3). To evaluate the performance of the BinaxNOW rapid antigen test, it was used along with real-time reverse transcription-polymerase chain reaction (RT-PCR) testing to analyze 3,419 paired specimens collected from persons aged ≥10 years at two community testing sites in Pima County, Arizona, during November 3-17, 2020. Viral culture was performed on 274 of 303 residual real-time RT-PCR specimens with positive results by either test (29 were not available for culture). Compared with real-time RT-PCR testing, the BinaxNOW antigen test had a sensitivity of 64.2% for specimens from symptomatic persons and 35.8% for specimens from asymptomatic persons, with near 100% specificity in specimens from both groups. Virus was cultured from 96 of 274 (35.0%) specimens, including 85 (57.8%) of 147 with concordant antigen and real-time RT-PCR positive results, 11 (8.9%) of 124 with false-negative antigen test results, and none of three with false-positive antigen test results. Among specimens positive for viral culture, sensitivity was 92.6% for symptomatic and 78.6% for asymptomatic individuals. When the pretest probability for receiving positive test results for SARS-CoV-2 is elevated (e.g., in symptomatic persons or in persons with a known COVID-19 exposure), a negative antigen test result should be confirmed by NAAT (1). Despite a lower sensitivity to detect infection, rapid antigen tests can be an important tool for screening because of their quick turnaround time, lower costs and resource needs, high specificity, and high positive predictive value (PPV) in settings of high pretest probability. The faster turnaround time of the antigen test can help limit transmission by more rapidly identifying infectious persons for isolation, particularly when used as a component of serial testing strategies.

Silence, an intangible something, through silencing creates, reveals, and transforms. It provides a space to examine psychological well-being as it removes the anchor tethering us to the temporal existence of our logical mind. From silence comes sound, and from sound silence. Neither mutually exclusive, sound and silence co-create one another, inextricably bound together through intentional force. The artistic expression of silence, as both ephemeral and ambiguous, allows for a personal transformative experience of opening to an authentic self. Music holds the power to envelop us within its sensorial embrace, enabling emotions to swell to the surface thereby creating a pause where self-revealment becomes possible. Existentialist ideology suggests the innate terror of nihilism clouds the human psyche, giving credence to our fear of non-existence. However, failure to leave the external noise and enter the silence between the notes resorts in a disillusionment of being, where the false self will ultimately crumble under the pressure to maintain its façade. Between the notes fosters introspection, allows an opening to well-being. It is here, in that silent space, that the authentic self can be discovered.

Inaccurate interpretation of negotiated nonverbal communication during an intimate encounter has serious moral and legal repercussions. Reciprocity between bodies allows one to assess the intention of the other. However, when the intended message is miscommunicated through the sender’s embodied action or misperceived by the receiver, a sexual assault can ensue. Understanding, conveying, and responding to behavioral gestures indicative of agreement or refusal to consent, is an emotional quagmire that has received global attention through sociopolitical movements such as #MeToo. Despite the desired cogitation of a pre-reflexive intentioned message, reciprocal navigation of a shared intimate space shifts within the corporeal/intercorporeal relationship, such that a habituated behavioral response, autonomic bodily responding, and socialized dating norms all have the potential to sabotage the essence of the original message. Seeking legal retribution is compromised in its application of objectified parameters to an ambiguous, subjective human interaction. While programs promoting slogans such as “Just Say No” are well intentioned, the complexity of human behavior, unconscious processes, and subjective perception, all suggest that communicating a refusal to consent extends far beyond the verbal utterance of saying “No.”

The COVID-19 pandemic required oncology nursing researchers to immediately and drastically adjust their research activities. During the 33rd Annual CANO/ ACIO Conference Roundtable Workshop October 2021 - Moving Research Forward During COVID-19, oncology nurses gathered to share and discuss strategies they will continue, conclude, and commence when leading research during and beyond the pandemic. Workshop participants identified the use of low technology, such as telephone and virtual calls without video, as a valuable data collection strategy they will continue for individual interviews. In contrast, attendees expressed their desire to stop conducting virtual focus groups when public health measures are lifted. Oncology nurses indicated an interest in beginning to use a hybrid in-person/virtual data collection approach and incorporate some technological features, such as QR codes, for recruiting participants. Workshop attendees also reflected on the impact of COVID-19 on oncology nursing practice and education, highlighting future research priorities and considerations.

Point-of-care antigen tests are an important tool for SARS-CoV-2 detection. Antigen tests are less sensitive than real-time reverse-transcriptase PCR (rRT-PCR). Data on the performance of the BinaxNOW antigen test compared to rRT-PCR and viral culture by symptom and known exposure status, timing during disease or exposure period and demographic variables are limited. During November 3rd-17th, 2020, we collected paired upper respiratory swab specimens to test for SARS-CoV-2 by rRT-PCR and Abbott BinaxNOW (BinaxNOW) antigen test at two community testing sites in Pima County, Arizona. We administered a questionnaire to capture symptoms, known exposure status and previous SARS-CoV-2 test results. Specimens positive by either test were analyzed by viral culture. Previously we showed overall BinaxNOW sensitivity was 52.5%. Here we showed BinaxNOW sensitivity increased to 65.7% among currently symptomatic individuals reporting a known exposure. BinaxNOW sensitivity was lower among participants with a known exposure and previously symptomatic (32.4%) or never symptomatic (47.1%) within 14 days of testing. Sensitivity was 71.1% in participants within a week of symptom onset. In participants with a known exposure, sensitivity was highest 8-10 days post-exposure (75%). The positive predictive value for recovery of virus in cell culture was 56.7% for BinaxNOW-positive and 35.4% for rRT-PCR-positive specimens. Result reporting time was 2.5 hours for BinaxNOW and 26 hours for rRT-PCR. Point-of-care antigen tests have a shorter turn-around time compared to laboratory-based nucleic acid amplification tests, which allows for more rapid identification of infected individuals. Antigen test sensitivity limitations are important to consider when developing a testing program.

Although people with autism are protected under the Americans with Disabilities Act of 1990, there is little theoretical or practical effort to determine whether traditional pre-employment assessments unfairly impact autistic job seekers. Due to the lack of emphasis on social communication, game-based assessments (GBAs) may offer a way of assessing candidate ability without disadvantaging autistic candidates. A total of 263 autistic job seekers took one of two game-based assessment packages designed to measure cognitive ability. After comparing their results to 323 college-graduate job seekers in the general population, we found that performance on the GBAs was generally similar in both populations, although some small differences were detected. Implications for hiring decisions are discussed.

PurposeThe challenges of achieving housing stability are examinable from a variety of locations and perspectives, resulting in a range of solutions and recommendations for practice. Attending to the experiences and understandings of both service users and service providers within a broad environmental scan, one can obtain a more complete picture of how housing stability can be supported and sustained. The purpose of this research is to better understand the practical landscape, human relationships, interdisciplinary understandings and everyday activities of housing stability.Design/methodology/approachThe paper draws on thematic analysis from expert informant interviews conducted during an environmental scan of housing options and facilities for those who have been labelled “hard to house” in a large, ethnically‐diverse urban city in western Canada. Interviews of selected service users yielded information on their perspectives of the barriers and facilitators of housing stability. Parallel interviews of service providers and/or policy makers were also conducted, and responses compared and contrasted with those of service users.FindingsThree interconnected patterns on the path to housing stability were experienced by the expert informants, and are explored herein. The overlapping and developmental themes “more than a house,” “finding support,” and “connecting multiple supports” are discussed. Conditions and realities of coordinated support need, particularly for those deemed “hard to house” because of addictions or mental health problems were revealed by the expert informants in this study.Research limitations/implicationsThematic analysis of the parallel interviews brought the landscape of housing stability into clearer focus and contributed to practice recommendations. This qualitative research approach was not intended to provide generalizable findings, but rather sheds light on particular experiences and understandings in ways that may contribute to further research. The themes identified may resonate in differing circumstances having arisen from the more generalized practical realities and social conditions which warrant an ongoing analysis.Practical implicationsThe analysis revealed an ongoing gap of support for the management and coordination of the often complex requirements of support for housing stability for service users. Various service agencies, providing houses, providing financial aid, providing health and social support need to “connect multiple levels of support” something identified as an all too often missing link in achieving housing stability. Recommendations include recognizing the necessity of multiple sectors working together with multiple sites and layers of support, in particular for those who experience addictions or mental health problems. More tailored support, follow up and recognition of the potential for instability is a particular practical implication of the study. Invigorating a coordinative, case management role, with a view to bridging and bringing together seemingly disparate sectors and service providers are relevant practical implications of this study.Originality/valueThe research is novel in approach, drawing on a parallel expert informant interview process, and findings are of relevance to practical activities in housing, social and health services and policy as well as for scholarly dialogue and discussion.

A new procedure called single-word shadowing was applied to the study of lexical access in context. Subjects listened to word pairs or sentences recorded in one voice and were asked to repeat the target word signaled by a voice shift. This technique yielded rapid and robust priming effects in normal adult subjects in word pairs and in a sentence context. Regression analyses showed that the semantic priming effects were large and significant, even when several additional factors believed to affect lexical access were controlled. Evidence was found for robust semantic priming in the healthy elderly and in children from 7 to 11 years of age, and there was also evidence for a change in the size and nature of context effects across the lifespan. Because single-word shadowing works across a broad age range and does not require reading, secondary tasks, or metalinguistic judgments, it is a promising tool for the study of lexical access in a range of different populations.

The effect of carbamazepine on inositol phospholipid metabolism was investigated in rat cerebral cortex. The stimulation of inositol phosphate formation by 5-HT (10 microM), carbachol (100 microM) and noradrenaline (30 microM) was not significantly altered by carbamazepine in vitro. 14 days treatment of rats in vivo with carbamazepine was similarly without effect on these parameters. In contrast 14 days treatment with LiCl reduced the agonist responses by 25-50%. The results are discussed in relation to the therapeutic actions of these drugs.