1. Mice With Genetically Determined High Susceptibility to Ultraviolet (UV)-Induced Immunosuppression Show Enhanced UV Carcinogenesis
- Author
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Edward C. De Fabo, Tracy M. Johnson, Thomas R. Fears, Frances P. Noonan, H. Konrad Muller, and D.F. Kusewitt
- Subjects
Male ,ultraviolet radiation ,Pathology ,medicine.medical_specialty ,Neoplasms, Radiation-Induced ,Ultraviolet Rays ,Ratón ,medicine.medical_treatment ,Vimentin ,Dermatology ,Biology ,medicine.disease_cause ,Biochemistry ,Mice ,03 medical and health sciences ,0302 clinical medicine ,Species Specificity ,Keratin ,Immune Tolerance ,medicine ,Animals ,Genetic Predisposition to Disease ,Molecular Biology ,030304 developmental biology ,chemistry.chemical_classification ,Mice, Inbred BALB C ,0303 health sciences ,immunosuppression ,skin cancer ,Dose-Response Relationship, Radiation ,Immunosuppression ,Cell Biology ,medicine.disease ,Immunohistochemistry ,Survival Analysis ,Molecular biology ,3. Good health ,Mice, Inbred C57BL ,Dose–response relationship ,risk factor ,chemistry ,030220 oncology & carcinogenesis ,biology.protein ,Female ,Skin cancer ,Carcinogenesis - Abstract
To assess the premise that genetically determined differences in susceptibility to UV-induced immunosuppression are reflected in UV carcinogenesis, we investigated UV skin cancer induction in two strains of reciprocal F1 hybrid mice CB6F1 males with high susceptibility to UV immunosuppression and a BALB/c X-chromosome and B6CF1 males with low susceptibility to UV immunosuppression and a C57BL/6 X-chromosome. Four experimental groups comprising both strains treated three times weekly with two UV regimens (daily doses incremented from 2.25 to 6 or 4.5 to 12 kJ per m2) were monitored for skin tumor development. Survival without a skin tumor differed over the four groups (p< 0.0001) and differed according to UV regimen within each strain (p
- Published
- 2003
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