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7 results on '"Tracey Dean"'

1. Good Practice Guidelines for the Assessment and Treatment of Adults with Gender Dysphoria

Author

Richard Green, Melissa Hines, Susan Carr, Del Loewenthal, Penny Lenihan, Michelle Ellis, James Barrett, Mike Besser, Andrew Messenger, Darren Skinner, Gabriel Ivbijaro, Vicky Williams, Emma Martin, Mark Hamilton, Daniel Wilson, Eli Coleman, Tracey Dean, Terry Reed, Dominic Walsh, Ben Thom, David Ralph, Angela Clayton, Jim Lucey, Jane Thornton, Dai Davies, Walter Pierre Bouman, Russell Reid, David Ward, Su Sethi, Philip McGarry, Paul Sutcliffe, John Stevens, Brian Ferguson, Maxine Rathbone, Alex Lawrence, Deenesh Khoosal, Domenico Di Ceglie, Tim R. Terry, Kevan Wylie, Michelle Bridgman, and Susan Brechin

Subjects
Value (ethics), Gender dysphoria, business.industry, Best practice, medicine.disease, Mental health, Gender reassignment surgery, Transsexual, Psychiatry and Mental health, Clinical Psychology, Nursing, Well-being, Transgender, Medicine, business
Abstract

The Good Practice Guidelines for the Assessment and Treatment of Adults with Gender Dysphoria is a publication of the Intercollegiate Committee of the Royal College of Psychiatrists. The overall goal of the Good Practice Guidelines is to provide clinical guidance for health professionals to assist transsexual, transgender, and gender nonconforming people with safe and effective pathways to achieving lasting personal comfort with their gendered selves, in order to maximize their overall health, psychological well-being, and self-fulfillment. This assistance may include primary care, gynaecologic and urologic care, reproductive options, voice and communication therapy, mental health services (e.g., assessment, counselling, psychotherapy), and hormonal and surgical treatments. The Good Practice Guidelines are based on the best available science and expert professional consensus. The Good Practice Guidelines articulate standards of care while acknowledging the role of making informed choices and the value of ...

Published
2014
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2. Rare variants and HLA haplotypes associated in patients with neuromyelitis optica spectrum disorders

Author

Inna Tabansky, Akemi J. Tanaka, Jiayao Wang, Guanglan Zhang, Irena Dujmovic, Simone Mader, Venkatesh Jeganathan, Tracey DeAngelis, Michael Funaro, Asaff Harel, Mark Messina, Maya Shabbir, Vishaan Nursey, William DeGouvia, Micheline Laurent, Karen Blitz, Peter Jindra, Mark Gudesblatt, Regeneron Genetics Center, Alejandra King, Jelena Drulovic, Edmond Yunis, Vladimir Brusic, Yufeng Shen, Derin B. Keskin, Souhel Najjar, and Joel N. H. Stern

Subjects
neuromyelitis optica spectrum disorders, human leukocyte antigen, exome sequencing, autoimmunity, antibody mediated, Immunologic diseases. Allergy, RC581-607
Abstract

Neuromyelitis optica spectrum disorders (NMOSD) are rare, debilitating autoimmune diseases of the central nervous system. Many NMOSD patients have antibodies to Aquaporin-4 (AQP4). Prior studies show associations of NMOSD with individual Human Leukocyte Antigen (HLA) alleles and with mutations in the complement pathway and potassium channels. HLA allele associations with NMOSD are inconsistent between populations, suggesting complex relationships between the identified alleles and risk of disease. We used a retrospective case-control approach to identify contributing genetic variants in patients who met the diagnostic criteria for NMOSD and their unaffected family members. Potentially deleterious variants identified in NMOSD patients were compared to members of their families who do not have the disease and to existing databases of human genetic variation. HLA sequences from patients from Belgrade, Serbia, were compared to the frequency of HLA haplotypes in the general population in Belgrade. We analyzed exome sequencing on 40 NMOSD patients and identified rare inherited variants in the complement pathway and potassium channel genes. Haplotype analysis further detected two haplotypes, HLA-A*01, B*08, DRB1*03 and HLA-A*01, B*08, C*07, DRB1*03, DQB1*02, which were more prevalent in NMOSD patients than in unaffected individuals. In silico modeling indicates that HLA molecules within these haplotypes are predicted to bind AQP4 at several sites, potentially contributing to the development of autoimmunity. Our results point to possible autoimmune and neurodegenerative mechanisms that cause NMOSD, and can be used to investigate potential NMOSD drug targets.

Published
2022
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6. Pilot clinical quality registry for dementia in Australia

Author

Karolina Krysinska, John James McNeil, Henry Brodaty, Susannah Ahern, Elsdon Storey, Arul Earnest, Robyn Woods, Nelson, Mark R., Joanne Tracey Dean, Danny Yearn Hian Liew, Joanne Ryan, Ayton, Darshini R., Madeleine Gardam, Elizabeth Pritchard, Sandra Robinson, and Stephanie Alison Ward

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