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3. Fatigue and quality of life during neoadjuvant chemotherapy of early breast cancer: a prospective multicenter cohort study

Author

Pelzer, Florian, primary, Tröger, Wilfried, additional, Reif, Marcus, additional, Schönberg, Susanne, additional, Martin, David D., additional, Müller, Cornelia, additional, Utz-Billing, Isabell, additional, Kühn, Thorsten, additional, Baumgartner, Stephan, additional, Kiechle, Marion, additional, and Paepke, Daniela, additional

Published
2023
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5. Assessing the order of magnitude of outcomes in single-arm cohorts through systematic comparison with corresponding cohorts: An example from the AMOS study

Author

Kienle Gunver S, Tröger Wilfried, Glockmann Anja, Hamre Harald J, and Kiene Helmut

Subjects
Medicine (General), R5-920
Abstract

Abstract Background When a therapy has been evaluated in the first clinical study, the outcome is often compared descriptively to outcomes in corresponding cohorts receiving other treatments. Such comparisons are often limited to selected studies, and often mix different outcomes and follow-up periods. Here we give an example of a systematic comparison to all cohorts with identical outcomes and follow-up periods. Methods The therapy to be compared (anthroposophic medicine, a complementary therapy system) had been evaluated in one single-arm cohort study: the Anthroposophic Medicine Outcomes Study (AMOS). The five largest AMOS diagnosis groups (A-cohorts: asthma, depression, low back pain, migraine, neck pain) were compared to all retrievable corresponding cohorts (C-cohorts) receiving other therapies with identical outcomes (SF-36 scales or summary measures) and identical follow-up periods (3, 6 or 12 months). Between-group differences (pre-post difference in an A-cohort minus pre-post difference in the respective C-cohort) were divided with the standard deviation (SD) of the baseline score of the A-cohort. Results A-cohorts (5 cohorts with 392 patients) were similar to C-cohorts (84 cohorts with 16,167 patients) regarding age, disease duration, baseline affection and follow-up rates. A-cohorts had ≥ 0.50 SD larger improvements than C-cohorts in 13.5% (70/517) of comparisons; improvements of the same order of magnitude (small or minimal differences: -0.49 to 0.49 SD) were found in 80.1% of comparisons; and C-cohorts had ≥ 0.50 SD larger improvements than A-cohorts in 6.4% of comparisons. Analyses stratified by diagnosis had similar results. Sensitivity analyses, restricting the comparisons to C-cohorts with similar study design (observational studies), setting (primary care) or interventions (drugs, physical therapies, mixed), or restricting comparisons to SF-36 scales with small baseline differences between A- and C-cohorts (-0.49 to 0.49 SD) also had similar results. Conclusion In this descriptive analysis, anthroposophic therapy was associated with SF-36 improvements largely of the same order of magnitude as improvements following other treatments. Although these non-concurrent comparisons cannot assess comparative effectiveness, they suggest that improvements in health status following anthroposophic therapy can be clinically meaningful. The analysis also demonstrates the value of a systematic approach when comparing a therapy cohort to corresponding therapy cohorts.

Published
2008
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12. World Congress Integrative Medicine & Health 2017: Part one

Author

Brinkhaus, Benno, primary, Falkenberg, Torkel, additional, Haramati, Aviad, additional, Willich, Stefan N., additional, Briggs, Josephine P., additional, Willcox, Merlin, additional, Linde, Klaus, additional, Theorell, Töres, additional, Wong, Lisa M., additional, Dusek, Jeffrey, additional, Wu, Darong, additional, Eisenberg, David, additional, Berger, Bettina, additional, Kemper, Kathi, additional, Stock-Schröer, Beate, additional, Sützl-Klein, Hedda, additional, Ferreri, Rosaria, additional, Kaplan, Gary, additional, Matthes, Harald, additional, Rotter, Gabriele, additional, Schiff, Elad, additional, Arnon, Zahi, additional, Hahn, Eckhard, additional, Luberto, Christina M., additional, Martin, David, additional, Schwarz, Silke, additional, Tauschel, Diethard, additional, Flower, Andrew, additional, Gramminger, Harsha, additional, Gupta, Hedwig H., additional, Gupta, S. N., additional, Kerckhoff, Annette, additional, Kessler, Christian S., additional, Michalsen, Andreas, additional, Kim, Eun S., additional, Jang, Eun H., additional, Kim, Rana, additional, Jan, Sae B., additional, Mittwede, Martin, additional, Mohme, Wiebke, additional, Ben-Arye, Eran, additional, Bonucci, Massimo, additional, Saad, Bashar, additional, Breitkreuz, Thomas, additional, Rossi, Elio, additional, Kebudi, Rejin, additional, Daher, Michel, additional, Razaq, Samaher, additional, Gafer, Nahla, additional, Nimri, Omar, additional, Hablas, Mohamed, additional, Kienle, Gunver Sophia, additional, Samuels, Noah, additional, Silbermann, Michael, additional, Bandelin, Lena, additional, Lang, Anna-Lena, additional, Wartner, Eva, additional, Holtermann, Christoph, additional, Binstock, Maxwell, additional, Riebau, Robert, additional, Mujkanovic, Edin, additional, Cramer, Holger, additional, Lauche, Romy, additional, Michalsen, Andres, additional, Ward, Lesley, additional, Irnich, Dominik, additional, Stör, Wolfram, additional, Burnstock, Geoffrey, additional, Schaible, Hans-Georg, additional, Ots, Thomas, additional, Langhorst, Jost, additional, Sundberg, Tobias, additional, Amarell, Catherina, additional, Anheyer, Melanie, additional, Eckert, Marion, additional, Ogal, Mercedes, additional, Schönauer, Annette, additional, Reisenberger, Birgit, additional, Brand, Bernhard, additional, Anheyer, Dennis, additional, Dobos, Gustav, additional, Kroez, Matthias, additional, Ammendola, Aldo, additional, Mao, Jun J., additional, Witt, Claudia, additional, Yang, Yufei, additional, Oritz, Miriam, additional, Horneber, Markus, additional, Voiß, Petra, additional, von Rosenstiel, Alexandra, additional, Amarell, Catharina, additional, Schad, Friedemann, additional, Schläppi, Marc, additional, Kröz, Matthias, additional, Büssing, Arndt, additional, Bar-Sela, Gil, additional, Avshalomov, David, additional, Attias, Samuel, additional, Brinkhaus, Benno, additional, Cotton, Sian, additional, Jong, Miek, additional, Jong, Mats, additional, Scheffer, Christian, additional, Edelhäuser, Friedrich, additional, AlBedah, Abdullah, additional, Lee, Myeong Soo, additional, Khalil, Mohamed, additional, Ogawa, Keiko, additional, Motoo, Yoshiharu, additional, Arimitsu, Junsuke, additional, Ogawa, Masao, additional, Shimizu, Genki, additional, Stange, Rainer, additional, Kraft, Karin, additional, Kuchta, Kenny, additional, Watanabe, Kenji, additional, Bonin, D, additional, Gruber, Harald, additional, Koch, Sabine, additional, Pohlmann, Urs, additional, Caldwell, Christine, additional, Krantz, Barbara, additional, Kortum, Ria, additional, Martin, Lily, additional, Wieland, Lisa S., additional, Kligler, Ben, additional, Gould-Fogerite, Susan, additional, Zhang, Yuqing, additional, Riva, John J., additional, Lumpkin, Michael, additional, Ratner, Emily, additional, Ping, Liu, additional, Jian, Pei, additional, Hamme, Gesa-Meyer, additional, Mao, Xiaosong, additional, Chouping, Han, additional, Schröder, Sven, additional, Hummelsberger, Josef, additional, Wullinger, Michael, additional, Brodzky, Marc, additional, Zalpour, Christoff, additional, Langley, Julia, additional, Weber, Wendy, additional, Mudd, Lanay M., additional, Wayne, Peter, additional, Witt, Clauda, additional, Weidenhammer, Wolfgang, additional, Fønnebø, Vinjar, additional, Boon, Heather, additional, Steel, Amie, additional, Bugarcic, Andrea, additional, Rangitakatu, Melisa, additional, Adams, Jon, additional, Sibbritt, David, additional, Wardle, Jon, additional, Leach, Matthew, additional, Schloss, Janet, additional, Dieze, Helene, additional, Ijaz, Nadine, additional, Heinrich, Michael, additional, Lewith, George, additional, Graz, Bertrand, additional, Adam, Daniela, additional, Grabenhenrich, Linus, additional, Ortiz, Miriam, additional, Binting, Sylvia, additional, Reinhold, Thomas, additional, Andermo, Susanne, additional, Nordberg, Johanna Hök, additional, Arman, Maria, additional, Bhasin, Manoj, additional, Fan, Xueyi, additional, Libermann, Towia, additional, Fricchione, Gregory, additional, Denninger, John, additional, Benson, Herbert, additional, Martin, David D., additional, Boers, Inge, additional, Vlieger, Arine, additional, Teut, Michael, additional, Ullmann, Alexander, additional, Lotz, Fabian, additional, Roll, Stephanie, additional, Canella, Claudia, additional, Mikolasek, Michael, additional, Rostock, Matthias, additional, Beyer, Jörg, additional, Guckenberger, Matthias, additional, Jenewein, Josef, additional, Linka, Esther, additional, Six, Claudia, additional, Stoll, Sarah, additional, Stupp, Roger, additional, Witt, Claudia M., additional, Chuang, Elisabeth, additional, McKee, Melissa D., additional, Klose, Petra, additional, Lange, Silke, additional, Chung, Vincent C. H., additional, Wong, Hoi L. C., additional, Wu, Xin Y., additional, Wen, Grace Y. G., additional, Ho, Robin S. T., additional, Ching, Jessica Y. L., additional, Wu, Justin C. Y., additional, Coakley, Amanda, additional, Flanagan, Jane, additional, Annese, Christine, additional, Empoliti, Joanne, additional, Gao, Zishan, additional, Liu, Xugang, additional, Yu, Shuguang, additional, Yan, Xianzhong, additional, Liang, Fanrong, additional, Hohmann, Christoph D., additional, Steckhan, Nico, additional, Ostermann, Thomas, additional, Paetow, Arion, additional, Hoff, Evelyn, additional, Hu, Xiao-Yang, additional, Wu, Ruo-Han, additional, Logue, Martin, additional, Blonde, Clara, additional, Lai, Lily Y., additional, Stuart, Beth, additional, Fei, Yu-Tong, additional, Moore, Michael, additional, Liu, Jian-Ping, additional, Jeitler, Michael, additional, Zillgen, Hannah, additional, Högl, Manuel, additional, Stöckigt, Barbara, additional, Seifert, Georg, additional, Kessler, Christian, additional, Khadivzadeh, Talat, additional, Bashtian, Maryam Hassanzadeh, additional, Aval, Shapour Badiee, additional, Esmaily, Habibollah, additional, Kim, Jihye, additional, Kim, Keun H., additional, Klocke, Carina, additional, Joos, Stefanie, additional, Koshak, Abdulrahman, additional, Wie, Li, additional, Koshak, Emad, additional, Wali, Siraj, additional, Alamoudi, Omer, additional, Demerdash, Abdulrahman, additional, Qutub, Majdy, additional, Pushparaj, Peter, additional, Kruse, Sigrid, additional, Fischer, Isabell, additional, Tremel, Nadine, additional, Rosenecker, Joseph, additional, Leung, Brenda, additional, Takeda, Wendy, additional, Liang, Ning, additional, Feng, Xue, additional, Liu, Jian-ping, additional, Cao, Hui-juan, additional, Shinday, Nina, additional, Philpotts, Lisa, additional, Park, Elyse, additional, Fricchione, Gregory L., additional, Yeh, Gloria, additional, Munk, Niki, additional, Zakeresfahani, Arash, additional, Foote, Trevor R., additional, Ralston, Rick, additional, Boulanger, Karen, additional, Özbe, Dominik, additional, Gräßel, Elmar, additional, Luttenberger, Katharina, additional, Pendergrass, Anna, additional, Pach, Daniel, additional, Bellmann-Strobl, Judit, additional, Chang, Yinhui, additional, Pasura, Laura, additional, Liu, Bin, additional, Jäger, Sven F., additional, Loerch, Ronny, additional, Jin, Li, additional, Icke, Katja, additional, Shi, Xuemin, additional, Paul, Friedemann, additional, Rütz, Michaela, additional, Lynen, Andreas, additional, Schömitz, Meike, additional, Vahle, Maik, additional, Salomon, Nir, additional, Lang, Alon, additional, Lahat, Adi, additional, Kopylov, Uri, additional, Ben-Horin, Shomron, additional, Har-Noi, Ofir, additional, Avidan, Benjamin, additional, Elyakim, Rami, additional, Gamus, Dorit, additional, NG, Siew, additional, Chang, Jessica, additional, Wu, Justin, additional, Kaimiklotis, John, additional, Schumann, Dania, additional, Buttó, Ludovica, additional, Haller, Dirk, additional, Smith, Caroline, additional, de Lacey, Sheryl, additional, Chapman, Michael, additional, Ratcliffe, Julie, additional, Johnson, Neil, additional, Lyttleton, Jane, additional, Boothroyd, Clare, additional, Fahey, Paul, additional, Tjaden, Bram, additional, van Vliet, Marja, additional, van Wietmarschen, Herman, additional, Tröger, Wilfried, additional, Vuolanto, Pia, additional, Aarva, Paulina, additional, Sorsa, Minna, additional, Helin, Kaija, additional, Wenzel, Claudia, additional, Zoderer, Iris, additional, Pammer, Patricia, additional, Simon, Patrick, additional, Tucek, Gerhard, additional, Wode, Kathrin, additional, Henriksson, Roger, additional, Sharp, Lena, additional, Stoltenberg, Anna, additional, Xiao-ying, Yang, additional, Wang, Li-qiong, additional, Li, Jin-gen, additional, Wang, Ying, additional, Balneaves, Lynda, additional, Capler, Rielle, additional, Bocci, Chiara, additional, Guffi, Marta, additional, Paolini, Marina, additional, Meaglia, Ilaria, additional, Porcu, Patrizia, additional, Ivaldi, Giovanni B., additional, Dragan, Simona, additional, Bucuras, Petru, additional, Pah, Ana M., additional, Badalica-Petrescu, Marius, additional, Buleu, Florina, additional, Hogea-Stoichescu, Gheorghe, additional, Christodorescu, Ruxandra, additional, Kao, Lan, additional, Cho, Yumin, additional, Klafke, Nadja, additional, Mahler, Cornelia, additional, von Hagens, Cornelia, additional, Uhlmann, Lorenz, additional, Bentner, Martina, additional, Schneeweiss, Andreas, additional, Mueller, Andreas, additional, Szecsenyi, Joachim, additional, Neri, Isabella, additional, Schnabel, Katharina, additional, Cree, Margit, additional, Suhr, Ralf, additional, Baccetti, Sonia, additional, Firenzuoli, Fabio, additional, Monechi, Maria V., additional, Di Stefano, Mariella, additional, Amunni, Gianni, additional, Wong, Wendy, additional, Chen, Bingzhong, additional, Amri, Hakima, additional, Kotlyanskaya, Lucy, additional, Anderson, Belinda, additional, Evans, Roni, additional, Marantz, Paul, additional, Bradley, Ryan, additional, Booth-LaForce, Cathryn, additional, Zwickey, Heather, additional, Kligler, Benjamin, additional, Brooks, Audrey, additional, Kreitzer, Mary J., additional, Lebensohn, Patricia, additional, Goldblatt, Elisabeth, additional, Esmel-Esmel, Neus, additional, Jiménez-Herrera, Maria, additional, Jocham, Alexandra, additional, Berberat, Pascal O., additional, Schneider, Antonius, additional, Masetti, Morgana, additional, Murakozy, Henriette, additional, Van Vliet, Marja, additional, Agdal, Rita, additional, Atarzadeh, Fatemeh, additional, Jaladat, Amir M., additional, Hoseini, Leila, additional, Amini, Fatemeh, additional, Bai, Chen, additional, Liu, Tiegang, additional, Zheng, Zian, additional, Wan, Yuxiang, additional, Xu, Jingnan, additional, Wang, Xuan, additional, Yu, He, additional, Gu, Xiaohong, additional, Daneshfard, Babak, additional, Nimrouzi, Majid, additional, Tafazoli, Vahid, additional, Alorizi, Seyed M. Emami, additional, Saghebi, Seyed A., additional, Fattahi, Mohammad R., additional, Salehi, Alireza, additional, Rezaeizadeh, Hossein, additional, Zarshenas, Mohammad M., additional, Fox, Kealoha, additional, Hughes, John, additional, Kostanjsek, Nenad, additional, Espinosa, Stéphane, additional, Fisher, Peter, additional, Latif, Abdul, additional, Lefeber, Donald, additional, Paske, William, additional, Öztürk, Ali Ö., additional, Öztürk, Gizemnur, additional, Tissing, Wim, additional, Naafs, Marianne, additional, Busch, Martine, additional, Sanaye, Mohammad R., additional, Dräger, Kilian, additional, Leininger, Brent, additional, Shafto, Kate, additional, Breen, Jenny, additional, Simões-Wüst, Ana P., additional, Moltó-Puigmartí, Carolina, additional, van Dongen, Martien, additional, Dagnelie, Pieter, additional, Thijs, Carel, additional, White, Shelley, additional, Wiesener, Solveig, additional, Salamonsen, Anita, additional, Stub, Trine, additional, Abanades, Sergio, additional, Blanco, Mar, additional, Masllorens, Laia, additional, Sala, Roser, additional, Al-Ahnoumy, Shafekah, additional, Han, Dongwoon, additional, He, Luzhu, additional, Kim, Ha Yun, additional, In Choi, Da, additional, Alræk, Terje, additional, Kristoffersen, Agnete, additional, von Sceidt, Christel, additional, Bruset, Stig, additional, Musial, Frauke, additional, Saha, Felix J., additional, Haller, Heidemarie, additional, Azizi, Hoda, additional, Khadem, Nayereh, additional, Hassanzadeh, Malihe, additional, Estiri, Nazanin, additional, Azizi, Hamideh, additional, Tavassoli, Fatemeh, additional, Lotfalizadeh, Marzieh, additional, Zabihi, Reza, additional, Shabestari, Mahmoud Mohammadzadeh, additional, Paeizi, Reza, additional, Azari, Masoumeh Alvandi, additional, Bahrami-Taghanaki, Hamidreza, additional, Baars, Erik, additional, De Bruin, Anja, additional, Ponstein, Anne, additional, Segantini, Sergio, additional, Monechi, Maria Valeria, additional, Voller, Fabio, additional, Barth, Jürgen, additional, Kern, Alexandra, additional, Lüthi, Sebastian, additional, Zieger, Anja, additional, Otto, Fabius, additional, Beccia, Ariel, additional, Dunlap, Corina, additional, Courneene, Brendan, additional, Bedregal, Paula, additional, Passi, Alvaro, additional, Rodríguez, Alfredo, additional, Chang, Mayling, additional, Gutiérrez, Soledad, additional, Beissner, Florian, additional, Preibisch, Christine, additional, Schweizer-Arau, Annemarie, additional, Popovici, Roxana, additional, Meissner, Karin, additional, Beljanski, Sylvie, additional, Belland, Laura, additional, Rivera-Reyes, Laura, additional, Hwang, Ula, additional, Sethe, Dominik, additional, Hilgard, Dörte, additional, Heusser, Peter, additional, Bishop, Felicity, additional, Al-Abbadey, Miznah, additional, Bradbury, Katherine, additional, Carnes, Dawn, additional, Dimitrov, Borislav, additional, Fawkes, Carol, additional, Foster, Jo, additional, MacPherson, Hugh, additional, Roberts, Lisa, additional, Yardley, Lucy, additional, Holmes, Michelle, additional, Little, Paul, additional, Cooper, Cyrus, additional, Bogani, Patrizia, additional, Maggini, Valentina, additional, Gallo, Eugenia, additional, Miceli, Elisangela, additional, Biffi, Sauro, additional, Mengoni, Alessio, additional, Fani, Renato, additional, Brands-Guendling, Nadine, additional, Guendling, Peter W., additional, Bronfort, Gert, additional, Haas, Mitch, additional, Schulz, Craig, additional, Bu, Xiangwei, additional, Wang, J., additional, Fang, T., additional, Shen, Z., additional, He, Y., additional, Zhang, X., additional, Zhang, Zhengju, additional, Wang, Dali, additional, Meng, Fengxian, additional, Baumann, Klaus, additional, Frick, Eckhard, additional, Jacobs, Christoph, additional, Grünther, Ralph-Achim, additional, Lötzke, Désirée, additional, Jung, Sonny, additional, Recchia, Daniela R., additional, Robens, Sibylle, additional, Stankewitz, Josephin, additional, Jeitler, Mika, additional, Cheon, Chunhoo, additional, Jang, Bo H., additional, Ko, Seong G., additional, Huang, Ching W., additional, Sasaki, Yui, additional, Ko, Youme, additional, Cheshire, Anna, additional, Ridge, Damien, additional, Peters, David, additional, Panagioti, Maria, additional, Simon, Chantal, additional, Cho, Hyun J., additional, Choi, Soo J., additional, Jung, Young S., additional, Im, Hyea B, additional, Cooley, Kieran, additional, Tummon-Simmons, Laura, additional, Wasson, Rachel, additional, Kraemer, Kristen, additional, Sears, Richard, additional, Hueber, Carly, additional, Derk, Gwendolyn, additional, Lill, JR, additional, An, Ruopeng, additional, Steinberg, Lois, additional, Rodriguez, Lourdes Diaz, additional, la Fuente, Francisca García-de, additional, De la Vega, Miguel, additional, Vargas-Román, Keyla, additional, Fernández-Ruiz, Jonatan, additional, Cantarero-Villanueva, Irene, additional, García-De la Fuente, Francisca, additional, Jiménez-Guerrero, Fanny, additional, Galiano-Castillo, Noelia, additional, Diaz-Saez, Gualberto, additional, Torres-Jimenez, José I., additional, Garcia-Gomez, Olga, additional, Hortal-Muñoz, Luis, additional, Diaz-Diez, Camino, additional, Dicen, Demijon, additional, Diezel, Helene, additional, Frawley, Jane, additional, Broom, Alex, additional, Dong, Fei, additional, Ma, Xueyan, additional, Yan, Liyi, additional, Wu, Liqun, additional, Ma, Jiaju, additional, Zhen, Jianhua, additional, Dubois, Julie, additional, Rodondi, Pierre-Yves, additional, Schwartze, Sophia, additional, Trapp, Barbara, additional, and Cysarz, Dirk, additional

Published
2017
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13. World Congress Integrative Medicine & Health 2017: Part one

Author

Brinkhaus, Benno, Falkenberg, Torkel, Haramati, Aviad, Willich, Stefan N, Briggs, Josephine P, Willcox, Merlin, Linde, Klaus, Theorell, Töres, Wong, Lisa M, Dusek, Jeffrey, Wu, Darong, Eisenberg, David, Berger, Bettina, Kemper, Kathi, Schröer, Beate, Klein, Hedda, Ferreri, Rosaria, Kaplan, Gary, Matthes, Harald, Rotter, Gabriele, Schiff, Elad, Arnon, Zahi, Hahn, Eckhard, Luberto, Christina M, Martin, David, Schwarz, Silke, Tauschel, Diethard, Flower, Andrew, Gramminger, Harsha, Gupta, Hedwig H, Gupta, S. N, Kerckhoff, Annette, Kessler, Christian S, Michalsen, Andreas, Kim, Eun S, Jang, Eun H, Kim, Rana, Jan, Sae B, Mittwede, Martin, Mohme, Wiebke, Arye, Eran, Bonucci, Massimo, Saad, Bashar, Breitkreuz, Thomas, Rossi, Elio, Kebudi, Rejin, Daher, Michel, Razaq, Samaher, Gafer, Nahla, Nimri, Omar, Hablas, Mohamed, Kienle, Gunver S, Samuels, Noah, Silbermann, Michael, Bandelin, Lena, Lang, Anna-Lena, Wartner, Eva, Holtermann, Christoph, Binstock, Maxwell, Riebau, Robert, Mujkanovic, Edin, Cramer, Holger, Lauche, Romy, Michalsen, Andres, Ward, Lesley, Irnich, Dominik, Stör, Wolfram, Burnstock, Geoffrey, Schaible, Hans-Georg, Ots, Thomas, Langhorst, Jost, Sundberg, Tobias, Amarell, Catherina, Anheyer, Melanie, Eckert, Marion, Ogal, Mercedes, Schönauer, Annette, Reisenberger, Birgit, Brand, Bernhard, Anheyer, Dennis, Dobos, Gustav, Kroez, Matthias, Ammendola, Aldo, Mao, Jun J, Witt, Claudia, Yang, Yufei, Oritz, Miriam, Horneber, Markus, Voiß, Petra, Rosenstiel, Alexandra, Amarell, Catharina, Schad, Friedemann, Schläppi, Marc, Kröz, Matthias, Büssing, Arndt, Sela, Gil, Avshalomov, David, Attias, Samuel, Cotton, Sian, Jong, Miek, Jong, Mats, Scheffer, Christian, Edelhäuser, Friedrich, AlBedah, Abdullah, Lee, Myeong S, Khalil, Mohamed, Ogawa, Keiko, Motoo, Yoshiharu, Arimitsu, Junsuke, Ogawa, Masao, Shimizu, Genki, Stange, Rainer, Kraft, Karin, Kuchta, Kenny, Watanabe, Kenji, Bonin, D, Gruber, Harald, Koch, Sabine, Pohlmann, Urs, Caldwell, Christine, Krantz, Barbara, Kortum, Ria, Martin, Lily, Wieland, Lisa S, Kligler, Ben, Fogerite, Susan, Zhang, Yuqing, Riva, John J, Lumpkin, Michael, Ratner, Emily, Ping, Liu, Jian, Pei, Hamme, Gesa-Meyer, Mao, Xiaosong, Chouping, Han, Schröder, Sven, Hummelsberger, Josef, Wullinger, Michael, Brodzky, Marc, Zalpour, Christoff, Langley, Julia, Weber, Wendy, Mudd, Lanay M, Wayne, Peter, Witt, Clauda, Weidenhammer, Wolfgang, Fønnebø, Vinjar, Boon, Heather, Steel, Amie, Bugarcic, Andrea, Rangitakatu, Melisa, Adams, Jon, Sibbritt, David, Wardle, Jon, Leach, Matthew, Schloss, Janet, Dieze, Helene, Ijaz, Nadine, Heinrich, Michael, Lewith, George, Graz, Bertrand, Adam, Daniela, Grabenhenrich, Linus, Ortiz, Miriam, Binting, Sylvia, Reinhold, Thomas, Andermo, Susanne, Nordberg, Johanna H, Arman, Maria, Bhasin, Manoj, Fan, Xueyi, Libermann, Towia, Fricchione, Gregory, Denninger, John, Benson, Herbert, Martin, David D, Boers, Inge, Vlieger, Arine, Teut, Michael, Ullmann, Alexander, Lotz, Fabian, Roll, Stephanie, Canella, Claudia, Mikolasek, Michael, Rostock, Matthias, Beyer, Jörg, Guckenberger, Matthias, Jenewein, Josef, Linka, Esther, Six, Claudia, Stoll, Sarah, Stupp, Roger, Witt, Claudia M, Chuang, Elisabeth, McKee, Melissa D, Klose, Petra, Lange, Silke, Chung, Vincent C H, Wong, Hoi L C, Wu, Xin Y, Wen, Grace Y G, Ho, Robin S T, Ching, Jessica Y L, Wu, Justin C Y, Coakley, Amanda, Flanagan, Jane, Annese, Christine, Empoliti, Joanne, Gao, Zishan, Liu, Xugang, Yu, Shuguang, Yan, Xianzhong, Liang, Fanrong, Hohmann, Christoph D, Steckhan, Nico, Ostermann, Thomas, Paetow, Arion, Hoff, Evelyn, Hu, Xiao-Yang, Wu, Ruo-Han, Logue, Martin, Blonde, Clara, Lai, Lily Y, Stuart, Beth, Fei, Yu-Tong, Moore, Michael, Liu, Jian-Ping, Jeitler, Michael, Zillgen, Hannah, Högl, Manuel, Stöckigt, Barbara, Seifert, Georg, Kessler, Christian, Khadivzadeh, Talat, Bashtian, Maryam H, Aval, Shapour B, Esmaily, Habibollah, Kim, Jihye, Kim, Keun H, Klocke, Carina, Joos, Stefanie, Koshak, Abdulrahman, Wie, Li, Koshak, Emad, Wali, Siraj, Alamoudi, Omer, Demerdash, Abdulrahman, Qutub, Majdy, Pushparaj, Peter, Kruse, Sigrid, Fischer, Isabell, Tremel, Nadine, Rosenecker, Joseph, Leung, Brenda, Takeda, Wendy, Liang, Ning, Feng, Xue, Liu, Jian-ping, Cao, Hui-juan, Shinday, Nina, Philpotts, Lisa, Park, Elyse, Fricchione, Gregory L, Yeh, Gloria, Munk, Niki, Zakeresfahani, Arash, Foote, Trevor R, Ralston, Rick, Boulanger, Karen, Özbe, Dominik, Gräßel, Elmar, Luttenberger, Katharina, Pendergrass, Anna, Pach, Daniel, Strobl, Judit, Chang, Yinhui, Pasura, Laura, Liu, Bin, Jäger, Sven F, Loerch, Ronny, Jin, Li, Icke, Katja, Shi, Xuemin, Paul, Friedemann, Rütz, Michaela, Lynen, Andreas, Schömitz, Meike, Vahle, Maik, Salomon, Nir, Lang, Alon, Lahat, Adi, Kopylov, Uri, Horin, Shomron, Noi, Ofir, Avidan, Benjamin, Elyakim, Rami, Gamus, Dorit, NG, Siew, Chang, Jessica, Wu, Justin, Kaimiklotis, John, Schumann, Dania, Buttó, Ludovica, Haller, Dirk, Smith, Caroline, Lacey, Sheryl, Chapman, Michael, Ratcliffe, Julie, Johnson, Neil, Lyttleton, Jane, Boothroyd, Clare, Fahey, Paul, Tjaden, Bram, Vliet, Marja, Wietmarschen, Herman, Tröger, Wilfried, Vuolanto, Pia, Aarva, Paulina, Sorsa, Minna, Helin, Kaija, Wenzel, Claudia, Zoderer, Iris, Pammer, Patricia, Simon, Patrick, Tucek, Gerhard, Wode, Kathrin, Henriksson, Roger, Sharp, Lena, Stoltenberg, Anna, ying, Yang, Wang, Li-qiong, Li, Jin-gen, Wang, Ying, Balneaves, Lynda, Capler, Rielle, Bocci, Chiara, Guffi, Marta, Paolini, Marina, Meaglia, Ilaria, Porcu, Patrizia, Ivaldi, Giovanni B, 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Jon, Leach, Matthew, Schloss, Janet, Dieze, Helene, Ijaz, Nadine, Heinrich, Michael, Lewith, George, Graz, Bertrand, Adam, Daniela, Grabenhenrich, Linus, Ortiz, Miriam, Binting, Sylvia, Reinhold, Thomas, Andermo, Susanne, Nordberg, Johanna H, Arman, Maria, Bhasin, Manoj, Fan, Xueyi, Libermann, Towia, Fricchione, Gregory, Denninger, John, Benson, Herbert, Martin, David D, Boers, Inge, Vlieger, Arine, Teut, Michael, Ullmann, Alexander, Lotz, Fabian, Roll, Stephanie, Canella, Claudia, Mikolasek, Michael, Rostock, Matthias, Beyer, Jörg, Guckenberger, Matthias, Jenewein, Josef, Linka, Esther, Six, Claudia, Stoll, Sarah, Stupp, Roger, Witt, Claudia M, Chuang, Elisabeth, McKee, Melissa D, Klose, Petra, Lange, Silke, Chung, Vincent C H, Wong, Hoi L C, Wu, Xin Y, Wen, Grace Y G, Ho, Robin S T, Ching, Jessica Y L, Wu, Justin C Y, Coakley, Amanda, Flanagan, Jane, Annese, Christine, Empoliti, Joanne, Gao, Zishan, Liu, Xugang, Yu, Shuguang, Yan, Xianzhong, Liang, Fanrong, Hohmann, Christoph D, Steckhan, Nico, Ostermann, Thomas, Paetow, Arion, Hoff, Evelyn, Hu, Xiao-Yang, Wu, Ruo-Han, Logue, Martin, Blonde, Clara, Lai, Lily Y, Stuart, Beth, Fei, Yu-Tong, Moore, Michael, Liu, Jian-Ping, Jeitler, Michael, Zillgen, Hannah, Högl, Manuel, Stöckigt, Barbara, Seifert, Georg, Kessler, Christian, Khadivzadeh, Talat, Bashtian, Maryam H, Aval, Shapour B, Esmaily, Habibollah, Kim, Jihye, Kim, Keun H, Klocke, Carina, Joos, Stefanie, Koshak, Abdulrahman, Wie, Li, Koshak, Emad, Wali, Siraj, Alamoudi, Omer, Demerdash, Abdulrahman, Qutub, Majdy, Pushparaj, Peter, Kruse, Sigrid, Fischer, Isabell, Tremel, Nadine, Rosenecker, Joseph, Leung, Brenda, Takeda, Wendy, Liang, Ning, Feng, Xue, Liu, Jian-ping, Cao, Hui-juan, Shinday, Nina, Philpotts, Lisa, Park, Elyse, Fricchione, Gregory L, Yeh, Gloria, Munk, Niki, Zakeresfahani, Arash, Foote, Trevor R, Ralston, Rick, Boulanger, Karen, Özbe, Dominik, Gräßel, Elmar, Luttenberger, Katharina, Pendergrass, Anna, Pach, Daniel, Strobl, Judit, Chang, Yinhui, Pasura, Laura, Liu, Bin, Jäger, Sven F, Loerch, Ronny, Jin, Li, Icke, Katja, Shi, Xuemin, Paul, Friedemann, Rütz, Michaela, Lynen, Andreas, Schömitz, Meike, Vahle, Maik, Salomon, Nir, Lang, Alon, Lahat, Adi, Kopylov, Uri, Horin, Shomron, Noi, Ofir, Avidan, Benjamin, Elyakim, Rami, Gamus, Dorit, NG, Siew, Chang, Jessica, Wu, Justin, Kaimiklotis, John, Schumann, Dania, Buttó, Ludovica, Haller, Dirk, Smith, Caroline, Lacey, Sheryl, Chapman, Michael, Ratcliffe, Julie, Johnson, Neil, Lyttleton, Jane, Boothroyd, Clare, Fahey, Paul, Tjaden, Bram, Vliet, Marja, Wietmarschen, Herman, Tröger, Wilfried, Vuolanto, Pia, Aarva, Paulina, Sorsa, Minna, Helin, Kaija, Wenzel, Claudia, Zoderer, Iris, Pammer, Patricia, Simon, Patrick, Tucek, Gerhard, Wode, Kathrin, Henriksson, Roger, Sharp, Lena, Stoltenberg, Anna, ying, Yang, Wang, Li-qiong, Li, Jin-gen, Wang, Ying, Balneaves, Lynda, Capler, Rielle, Bocci, Chiara, Guffi, Marta, Paolini, Marina, Meaglia, Ilaria, Porcu, Patrizia, Ivaldi, Giovanni B, Dragan, Simona, Bucuras, Petru, Pah, Ana M, Petrescu, Marius, Buleu, Florina, Stoichescu, Gheorghe, Christodorescu, Ruxandra, Kao, Lan, Cho, Yumin, Klafke, Nadja, Mahler, Cornelia, von Hagens, Cornelia, Uhlmann, Lorenz, Bentner, Martina, Schneeweiß, Andreas, Mueller, Andreas, Szecsenyi, Joachim, Neri, Isabella, Schnabel, Katharina, Cree, Margit, Suhr, Ralf, Baccetti, Sonia, Firenzuoli, Fabio, Monechi, Maria V, Stefano, Mariella, Amunni, Gianni, Wong, Wendy, Chen, Bingzhong, Amri, Hakima, Kotlyanskaya, Lucy, Anderson, Belinda, Evans, Roni, Marantz, Paul, Bradley, Ryan, LaForce, Cathryn, Zwickey, Heather, Kligler, Benjamin, Brooks, Audrey, Kreitzer, Mary J, Lebensohn, Patricia, Goldblatt, Elisabeth, Esmel, Neus, Herrera, Maria, Jocham, Alexandra, Berberat, Pascal O, Schneider, Antonius, Masetti, Morgana, Murakozy, Henriette, Agdal, Rita, Atarzadeh, Fatemeh, Jaladat, Amir M, Hoseini, Leila, Amini, Fatemeh, Bai, Chen, Liu, Tiegang, Zheng, Zian, Wan, Yuxiang, Xu, Jingnan, Wang, Xuan, Yu, He, Gu, Xiaohong, Daneshfard, Babak, Nimrouzi, Majid, Tafazoli, Vahid, Alorizi, Seyed M E, Saghebi, Seyed A, Fattahi, Mohammad R, Salehi, Alireza, Rezaeizadeh, Hossein, Zarshenas, Mohammad M, Fox, Kealoha, Hughes, John, Kostanjsek, Nenad, Espinosa, Stéphane, Fisher, Peter, Latif, Abdul, Lefeber, Donald, Paske, William, Öztürk, Ali Ö, Öztürk, Gizemnur, Tissing, Wim, Naafs, Marianne, Busch, Martine, Sanaye, Mohammad R, Dräger, Kilian, Leininger, Brent, Shafto, Kate, Breen, Jenny, Wüst, Ana P, Puigmartí, Carolina, Dongen, Martien, Dagnelie, Pieter, Thijs, Carel, White, Shelley, Wiesener, Solveig, Salamonsen, Anita, Stub, Trine, Abanades, Sergio, Blanco, Mar, Masllorens, Laia, Sala, Roser, Ahnoumy, Shafekah, Han, Dongwoon, He, Luzhu, Kim, Ha Y, Choi, Da, Alræk, Terje, Kristoffersen, Agnete, Sceidt, Christel, Bruset, Stig, Musial, Frauke, Saha, Felix J, Haller, Heidemarie, Azizi, Hoda, Khadem, Nayereh, Hassanzadeh, Malihe, Estiri, Nazanin, Azizi, Hamideh, Tavassoli, Fatemeh, Lotfalizadeh, Marzieh, Zabihi, Reza, Shabestari, Mahmoud M, Paeizi, Reza, Azari, Masoumeh A, Taghanaki, Hamidreza, Baars, Erik, Bruin, Anja, Ponstein, Anne, Segantini, Sergio, Voller, Fabio, Barth, Jürgen, Kern, Alexandra, Lüthi, Sebastian, Zieger, Anja, Otto, Fabius, Beccia, Ariel, Dunlap, Corina, Courneene, Brendan, Bedregal, Paula, Passi, Alvaro, Rodríguez, Alfredo, Chang, Mayling, Gutiérrez, Soledad, Beissner, Florian, Preibisch, Christine, Arau, Annemarie, Popovici, Roxana, Meissner, Karin, Beljanski, Sylvie, Belland, Laura, Reyes, Laura, Hwang, Ula, Sethe, Dominik, Hilgard, Dörte, Heusser, Peter, Bishop, Felicity, Abbadey, Miznah, Bradbury, Katherine, Carnes, Dawn, Dimitrov, Borislav, Fawkes, Carol, Foster, Jo, MacPherson, Hugh, Roberts, Lisa, Yardley, Lucy, Holmes, Michelle, Little, Paul, Cooper, Cyrus, Bogani, Patrizia, Maggini, Valentina, Gallo, Eugenia, Miceli, Elisangela, Biffi, Sauro, Mengoni, Alessio, Fani, Renato, Guendling, Nadine, Guendling, Peter W, Bronfort, Gert, Haas, Mitch, Schulz, Craig, Bu, Xiangwei, Wang, J., Fang, T., Shen, Z., He, Y., Zhang, X., Zhang, Zhengju, Wang, Dali, Meng, Fengxian, Baumann, Klaus, Frick, Eckhard, Jacobs, Christoph, Grünther, Ralph-Achim, Lötzke, Désirée, Jung, Sonny, Recchia, Daniela R, Robens, Sibylle, Stankewitz, Josephin, Jeitler, Mika, Cheon, Chunhoo, Jang, Bo H, Ko, Seong G, Huang, Ching W, Sasaki, Yui, Ko, Youme, Cheshire, Anna, Ridge, Damien, Peters, David, Panagioti, Maria, Simon, Chantal, Cho, Hyun J, Choi, Soo J, Jung, Young S, Im, Hyea B, Cooley, Kieran, Simmons, Laura, Wasson, Rachel, Kraemer, Kristen, Sears, Richard, Hueber, Carly, Derk, Gwendolyn, Lill, JR, An, Ruopeng, Steinberg, Lois, Rodriguez, Lourdes D, Fuente, Francisca G, Vega, Miguel, Román, Keyla, Ruiz, Jonatan, Villanueva, Irene, Fuente, Francisca, Guerrero, Fanny, Castillo, Noelia, Saez, Gualberto, Jimenez, José I, Gomez, Olga, Muñoz, Luis, Diez, Camino, Dicen, Demijon, Diezel, Helene, Frawley, Jane, Broom, Alex, Dong, Fei, Ma, Xueyan, Yan, Liyi, Wu, Liqun, Ma, Jiaju, Zhen, Jianhua, Dubois, Julie, Rodondi, Pierre-Yves, Schwartze, Sophia, Trapp, Barbara, and Cysarz, Dirk

Published
2017
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31. Quality of Life of Patients With Advanced Pancreatic Cancer During Treatment With Mistletoe: A Randomized Controlled Trial.

Author

Tröger, Wilfried, Galun, Danijel, Reif, Marcus, Schumann, Agnes, Stanković, Nikola, Milićević, Miroslav, Neubauer, Andreas, Bühler, Wien Hartmut, Pollmeier, Martin, Hübner, Jutta, Wörmann, Bernhard, Lelgemann, Monika, Wild, Claudia, Antes, Gerd, Edler, Lutz, Ernst, Edzard, Gärtner, Jan, Schmacke, Norbert, and Meyer, Frank P.

Abstract

A letter to the editor is presented in response to the article "Quality of life of patients with advanced pancreatic cancer during treatment with mistletoe: a randomized controlled trial" by D. Galun in the 2014 issue and also a reply from the author on the same.

Published
2015
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32. Mistletoe Extract Reduces the Surgical Suppression of Natural Killer Cell Activity in Cancer Patients. A Randomized Phase III Trial.

Author

Schink, Michael, Tröger, Wilfried, Dabidian, Ali, Goyert, Andreas, Scheuerecker, Heinz, Meyer, Johannes, Fischer, Imma U., and Glaser, Florian

Abstract

The article provides information on a study which investigated the influence of a perioperative infusion of a standardized mistletoe extract on immune functions. The study tested the effects of a single perioperative infusion of a mistletoe extract on postoperative immune suppression of natural killer (NK) cells and monocytes in patients undergoing surgery for colorectal cancer. The study enrolled patients with colorectal cancer undergoing open tumour resection. The patients where randomly assigned to either mistletoe infusion or no additional therapy.

Published
2007
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33. Preparation of human and murine monoclonal antibodies: antigens combined with or conjugated to lipopeptides constitute potent immunogens for in vitro and in vivo immunizations

Author

Hoffmann, Petra, primary, Jimenez-Diaz, Manuel, additional, Loleit, Manuel, additional, Tröger, Wilfried, additional, Wiesmüller, Karl-Heinz, additional, Metzger, Jörg, additional, Jung, Günter, additional, Kaiser, Ines, additional, Stöcklin, Siglinde, additional, Lenzner, Susanne, additional, Peters, J. Hinrich, additional, Grimm, Rudolf, additional, Schäfer, Eberhard, additional, and Bessler, Wolfgang G., additional

Published
1990
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34. Antigenic epitopes of NEF proteins from different HIV-1 strains as recognized by Sera from patients with manifest and latent HIV infection

Author

Gombert, Frank Otto, primary, Blecha, Wolfram, additional, Tähtinen, Maria, additional, Ranki, Annamari, additional, Pfeifer, Sigrun, additional, Tröger, Wilfried, additional, Braun, Rüdiger, additional, Müller-Lantzsch, Nikolaus, additional, Jung, Günther, additional, Rijbsamen-Waigmann, Helga, additional, and Krohn, Kai, additional

Published
1990
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37. World Congress Integrative Medicine & Health 2017: Part one : Berlin, Germany. 3-5 May 2017

Author

Brinkhaus, Benno, Falkenberg, Torkel, Haramati, Aviad, Willich, Stefan N., Briggs, Josephine P., Willcox, Merlin, Linde, Klaus, Theorell, Töres, Wong, Lisa M., Dusek, Jeffrey, Wu, Darong, Eisenberg, David, Berger, Bettina, Kemper, Kathi, Stock-Schröer, Beate, Sützl-Klein, Hedda, Ferreri, Rosaria, Kaplan, Gary, Matthes, Harald, Rotter, Gabriele, Schiff, Elad, Arnon, Zahi, Hahn, Eckhard, Luberto, Christina M., Martin, David, Schwarz, Silke, Tauschel, Diethard, Flower, Andrew, Gramminger, Harsha, Gupta, Hedwig H., Gupta, S. N., Kerckhoff, Annette, Kessler, Christian S., Michalsen, Andreas, Kim, Eun S., Jang, Eun H., Kim, Rana, Jan, Sae B., Mittwede, Martin, Mohme, Wiebke, Ben-Arye, Eran, Bonucci, Massimo, Saad, Bashar, Breitkreuz, Thomas, Rossi, Elio, Kebudi, Rejin, Daher, Michel, Razaq, Samaher, Gafer, Nahla, Nimri, Omar, Hablas, Mohamed, Kienle, Gunver Sophia, Samuels, Noah, Silbermann, Michael, B, Elin, Lena, Lang, Anna-Lena, Wartner, Eva, Holtermann, Christoph, Binstock, Maxwell, Riebau, Robert, Mujkanovic, Edin, Cramer, Holger, Lauche, Romy, Michalsen, Andres, Ward, Lesley, Irnich, Dominik, Stör, Wolfram, Burnstock, Geoffrey, Schaible, Hans-Georg, Ots, Thomas, Langhorst, Jost, Sundberg, Tobias, Amarell, Catherina, Anheyer, Melanie, Eckert, Marion, Ogal, Mercedes, Schönauer, Annette, Reisenberger, Birgit, Bernhard, Dennis Anheyer, Dobos, Gustav, Kroez, Matthias, Ammendola, Aldo, Mao, Jun J., Witt, Claudia, Yang, Yufei, Oritz, Miriam, Horneber, Markus, Voiß, Petra, Rosenstiel, Alex, Amarell, Catharina, Schad, Friedemann, Schläppi, Marc, Kröz, Matthias, Büssing, Arndt, Bar-Sela, Gil, Avshalomov, David, Attias, Samuel, Cotton, Sian, Jong, Miek, Jong, Mats, Scheffer, Christian, Edelhäuser, Friedrich, Albedah, Abdullah, Lee, Myeong Soo, Khalil, Mohamed, Ogawa, Keiko, Motoo, Yoshiharu, Arimitsu, Junsuke, Ogawa, Masao, Shimizu, Genki, Stange, Rainer, Kraft, Karin, Kuchta, Kenny, Watanabe, Kenji, Bonin, D., Gruber, Harald, Koch, Sabine, Pohlmann, Urs, Caldwell, Christine, Krantz, Barbara, Kortum, Ria, Martin, Lily, Wiel, Lisa S., Kligler, Ben, Gould-Fogerite, Susan, Zhang, Yuqing, Riva, John J., Lumpkin, Michael, Ratner, Emily, Ping, Liu, Jian, Pei, Hamme, Gesa-Meyer, Mao, Xiaosong, Chouping, Han, Schröder, Sven, Hummelsberger, Josef, Wullinger, Michael, Brodzky, Marc, Zalpour, Christoff, Langley, Julia, Weber, Wendy, Mudd, Lanay M., Wayne, Peter, Witt, Clauda, Weidenhammer, Wolfgang, Fønnebø, Vinjar, Boon, Heather, Steel, Amie, Bugarcic, Andrea, Rangitakatu, Melisa, Adams, Jon, Sibbritt, David, Wardle, Jon, Leach, Matthew, Schloss, Janet, Dieze, Helene, Ijaz, Nadine, Heinrich, Michael, Lewith, George, Graz, Bertr, Adam, Daniela, Grabenhenrich, Linus, Ortiz, Miriam, Binting, Sylvia, Reinhold, Thomas, Andermo, Susanne, Nordberg, Johanna Hök, Arman, Maria, Bhasin, Manoj, Fan, Xueyi, Libermann, Towia, Fricchione, Gregory, Denninger, John, Benson, Herbert, Martin, David D., Boers, Inge, Vlieger, Arine, Teut, Michael, Ullmann, Alex, Lotz, Fabian, Roll, Stephanie, Canella, Claudia, Mikolasek, Michael, Rostock, Matthias, Beyer, Jörg, Guckenberger, Matthias, Jenewein, Josef, Linka, Esther, Six, Claudia, Stoll, Sarah, Stupp, Roger, Witt, Claudia M., Chuang, Elisabeth, Mckee, Melissa D., Klose, Petra, Lange, Silke, Chung, Vincent C. H., Wong, Hoi L. C., Wu, Xin Y., Wen, Grace Y. G., Ho, Robin S. T., Ching, Jessica Y. L., Wu, Justin C. Y., Coakley, Am, a, Flanagan, Jane, Annese, Christine, Empoliti, Joanne, Gao, Zishan, Liu, Xugang, Yu, Shuguang, Yan, Xianzhong, Liang, Fanrong, Hohmann, Christoph D., Steckhan, Nico, Ostermann, Thomas, Paetow, Arion, Hoff, Evelyn, Hu, Xiao-Yang, Wu, Ruo-Han, Logue, Martin, Blonde, Clara, Lai, Lily Y., Stuart, Beth, Fei, Yu-Tong, Moore, Michael, Liu, Jian-Ping, Jeitler, Michael, Zillgen, Hannah, Högl, Manuel, Stöckigt, Barbara, Seifert, Georg, Kessler, Christian, Khadivzadeh, Talat, Bashtian, Maryam Hassanzadeh, Aval, Shapour Badiee, Esmaily, Habibollah, Kim, Jihye, Kim, Keun H., Klocke, Carina, Joos, Stefanie, Koshak, Abdulrahman, Wie, Li, Koshak, Emad, Wali, Siraj, Alamoudi, Omer, Demerdash, Abdulrahman, Qutub, Majdy, Pushparaj, Peter, Kruse, Sigrid, Fischer, Isabell, Tremel, Nadine, Rosenecker, Joseph, Leung, Brenda, Takeda, Wendy, Liang, Ning, Feng, Xue, Cao, Hui-Juan, Shinday, Nina, Philpotts, Lisa, Park, Elyse, Fricchione, Gregory L., Yeh, Gloria, Munk, Niki, Zakeresfahani, Arash, Foote, Trevor R., Ralston, Rick, Boulanger, Karen, Özbe, Dominik, Gräßel, Elmar, Luttenberger, Katharina, Pendergrass, Anna, Pach, Daniel, Bellmann-Strobl, Judit, Chang, Yinhui, Pasura, Laura, Liu, Bin, Jäger, Sven F., Loerch, Ronny, Jin, Li, Icke, Katja, Shi, Xuemin, Paul, Friedemann, Rütz, Michaela, Lynen, Andreas, Schömitz, Meike, Vahle, Maik, Salomon, Nir, Lang, Alon, Lahat, Adi, Kopylov, Uri, Ben-Horin, Shomron, Har-Noi, Ofir, Avidan, Benjamin, Elyakim, Rami, Gamus, Dorit, Ng, Siew, Chang, Jessica, Wu, Justin, Kaimiklotis, John, Schumann, Dania, Buttó, Ludovica, Haller, Dirk, Smith, Caroline, Lacey, Sheryl, Chapman, Michael, Ratcliffe, Julie, Johnson, Neil, Lyttleton, Jane, Boothroyd, Clare, Fahey, Paul, Tjaden, Bram, Vliet, Marja, Wietmarschen, Herman, Tröger, Wilfried, Vuolanto, Pia, Aarva, Paulina, Sorsa, Minna, Helin, Kaija, Wenzel, Claudia, Zoderer, Iris, Pammer, Patricia, Simon, Patrick, Tucek, Gerhard, Wode, Kathrin, Henriksson, Roger, Sharp, Lena, Stoltenberg, Anna, Xiao-Ying, Yang, Wang, Li-Qiong, Li, Jin-Gen, Wang, Ying, Balneaves, Lynda, Capler, Rielle, Bocci, Chiara, Guffi, Marta, Paolini, Marina, Meaglia, Ilaria, Porcu, Patrizia, Ivaldi, Giovanni B., Dragan, Simona, Bucuras, Petru, Pah, Ana M., Badalica-Petrescu, Marius, Buleu, Florina, Hogea-Stoichescu, Gheorghe, Christodorescu, Rux, Kao, Lan, Cho, Yumin, Klafke, Nadja, Mahler, Cornelia, Hagens, Cornelia, Uhlmann, Lorenz, Bentner, Martina, Schneeweiss, Andreas, Mueller, Andreas, Szecsenyi, Joachim, Neri, Isabella, Schnabel, Katharina, Cree, Margit, Suhr, Ralf, Baccetti, Sonia, Firenzuoli, Fabio, Monechi, Maria V., Di Stefano, Mariella, Amunni, Gianni, Wong, Wendy, Chen, Bingzhong, Amri, Hakima, Kotlyanskaya, Lucy, Anderson, Belinda, Evans, Roni, Marantz, Paul, Bradley, Ryan, Booth-Laforce, Cathryn, Zwickey, Heather, Kligler, Benjamin, Brooks, Audrey, Kreitzer, Mary J., Lebensohn, Patricia, Goldblatt, Elisabeth, Esmel-Esmel, Neus, Jiménez-Herrera, Maria, Jocham, Alex, Berberat, Pascal O., Schneider, Antonius, Masetti, Morgana, Murakozy, Henriette, Agdal, Rita, Atarzadeh, Fatemeh, Jaladat, Amir M., Hoseini, Leila, Amini, Fatemeh, Bai, Chen, Liu, Tiegang, Zheng, Zian, Wan, Yuxiang, Xu, Jingnan, Wang, Xuan, Yu, He, Gu, Xiaohong, Daneshfard, Babak, Nimrouzi, Majid, Tafazoli, Vahid, Alorizi, Seyed M. Emami, Saghebi, Seyed A., Fattahi, Mohammad R., Salehi, Alireza, Rezaeizadeh, Hossein, Zarshenas, Mohammad M., Fox, Kealoha, Hughes, John, Kostanjsek, Nenad, Espinosa, Stéphane, Fisher, Peter, Latif, Abdul, Lefeber, Donald, Paske, William, Öztürk, Ali Ö, Öztürk, Gizemnur, Tissing, Wim, Naafs, Marianne, Busch, Martine, Sanaye, Mohammad R., Dräger, Kilian, Leininger, Brent, Shafto, Kate, Breen, Jenny, Simões-Wüst, Ana P., Moltó-Puigmartí, Carolina, Dongen, Martien, Dagnelie, Pieter, Thijs, Carel, White, Shelley, Wiesener, Solveig, Salamonsen, Anita, Stub, Trine, Abanades, Sergio, Blanco, Mar, Masllorens, Laia, Sala, Roser, Al-Ahnoumy, Shafekah, Han, Dongwoon, He, Luzhu, Kim, Ha Yun, In Choi, Da, Alræk, Terje, Kristoffersen, Agnete, Sceidt, Christel, Bruset, Stig, Musial, Frauke, Anheyer, Dennis, Saha, Felix J., Haller, Heidemarie, Azizi, Hoda, Khadem, Nayereh, Hassanzadeh, Malihe, Estiri, Nazanin, Azizi, Hamideh, Tavassoli, Fatemeh, Lotfalizadeh, Marzieh, Zabihi, Reza, Shabestari, Mahmoud Mohammadzadeh, Paeizi, Reza, Azari, Masoumeh Alv, i, Bahrami-Taghanaki, Hamidreza, Baars, Erik, Bruin, Anja, Ponstein, Anne, Segantini, Sergio, Monechi, Maria Valeria, Voller, Fabio, Barth, Jürgen, Kern, Alex, Lüthi, Sebastian, Zieger, Anja, Otto, Fabius, Beccia, Ariel, Dunlap, Corina, Courneene, Brendan, Bedregal, Paula, Passi, Alvaro, Rodríguez, Alfredo, Chang, Mayling, Gutiérrez, Soledad, Beissner, Florian, Preibisch, Christine, Schweizer-Arau, Annemarie, Popovici, Roxana, Meissner, Karin, Beljanski, Sylvie, Bell, Laura, Rivera-Reyes, Laura, Hwang, Ula, Sethe, Dominik, Hilgard, Dörte, Heusser, Peter, Bishop, Felicity, Al-Abbadey, Miznah, Bradbury, Katherine, Carnes, Dawn, Dimitrov, Borislav, Fawkes, Carol, Foster, Jo, Macpherson, Hugh, Roberts, Lisa, Yardley, Lucy, Holmes, Michelle, Little, Paul, Cooper, Cyrus, Bogani, Patrizia, Maggini, Valentina, Gallo, Eugenia, Miceli, Elisangela, Biffi, Sauro, Mengoni, Alessio, Fani, Renato, S-Guendling, Nadine, Guendling, Peter W., Bronfort, Gert, Haas, Mitch, Schulz, Craig, Bu, Xiangwei, Wang, J., Fang, T., Shen, Z., He, Y., Zhang, X., Zhang, Zhengju, Wang, Dali, Meng, Fengxian, Baumann, Klaus, Frick, Eckhard, Jacobs, Christoph, Grünther, Ralph-Achim, Lötzke, Désirée, Jung, Sonny, Recchia, Daniela R., Robens, Sibylle, Stankewitz, Josephin, Jeitler, Mika, Cheon, Chunhoo, Jang, Bo H., Ko, Seong G., Huang, Ching W., Sasaki, Yui, Ko, Youme, Cheshire, Anna, Ridge, Damien, Peters, David, Panagioti, Maria, Simon, Chantal, Cho, Hyun J., Choi, Soo J., Jung, Young S., Im, Hyea B., Cooley, Kieran, Tummon-Simmons, Laura, Wasson, Rachel, Kraemer, Kristen, Sears, Richard, Hueber, Carly, Derk, Gwendolyn, Lill, Jr, An, Ruopeng, Steinberg, Lois, Rodriguez, Lourdes Diaz, La Fuente, Francisca García-De, La Vega, Miguel, Vargas-Román, Keyla, Fernández-Ruiz, Jonatan, Cantarero-Villanueva, Irene, García-De La Fuente, Francisca, Jiménez-Guerrero, Fanny, Galiano-Castillo, Noelia, Diaz-Saez, Gualberto, Torres-Jimenez, José I., Garcia-Gomez, Olga, Hortal-Muñoz, Luis, Diaz-Diez, Camino, Dicen, Demijon, Diezel, Helene, Frawley, Jane, Broom, Alex, Dong, Fei, Ma, Xueyan, Yan, Liyi, Wu, Liqun, Ma, Jiaju, Zhen, Jianhua, Dubois, Julie, Rodondi, Pierre-Yves, Schwartze, Sophia, Trapp, Barbara, and Cysarz, Dirk

Subjects
0106 biological sciences, 0301 basic medicine, medicine.medical_specialty, business.industry, Alternative medicine, General Medicine, 01 natural sciences, 03 medical and health sciences, 030104 developmental biology, Complementary and alternative medicine, Family medicine, medicine, Integrative medicine, business, 010606 plant biology & botany

38. In reply.

Author

Tröger W

Subjects
Humans, Mistletoe chemistry, Pain epidemiology, Pancreatic Neoplasms drug therapy, Pancreatic Neoplasms psychology, Phytotherapy methods, Plant Extracts therapeutic use, Quality of Life psychology
Published
2015
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39. Five-year follow-up of patients with early stage breast cancer after a randomized study comparing additional treatment with viscum album (L.) extract to chemotherapy alone.

Author

Tröger W, Zdrale Z, Stanković N, and Matijašević M

Abstract

Additional therapy with extracts of Viscum album [L.] (VaL) increases the quality of life of patients suffering from early stage breast cancer during chemotherapy. In the current study patients received chemotherapy, consisting of six cycles of cyclophosphamide, anthracycline, and 5-Fluoro-Uracil (CAF). Two groups also received one of two VaL extracts differing in their preparation as subcutaneous injection three times per week. A control group received CAF with no additional therapy. Six of 28 patients in one of the VaL groups and eight of 29 patients in the control group developed relapse or metastasis within 5 years. Subgroup analysis for hormone- and radiotherapy also showed no difference between groups. Additional VaL therapy during chemotherapy of early stage breast cancer patients appears not to influence the frequency of relapse or metastasis within 5 years.

Published
2012
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40. Pulpa dentis D30 for acute reversible pulpitis: A prospective cohort study in routine dental practice.

Author

Hamre HJ, Mittag I, Glockmann A, Kiene H, and Tröger W

Subjects
Acute Disease, Adult, Animals, Cattle, Cohort Studies, Dental Pulp, Female, Humans, Male, Middle Aged, Pain etiology, Pain Measurement, Prospective Studies, Pulpitis complications, Single-Blind Method, Treatment Outcome, Young Adult, Dental Care methods, Homeopathy methods, Pain Management, Pulpitis therapy
Abstract

Background: Pulpa dentis D30 (PD: dental pulp of the calf, prepared in a homeopathic D30 potency) has been used in acute reversible pulpitis for pain relief and to avoid or postpone invasive dental treatment., Primary Study Objective: To study short-term clinical outcomes of PD therapy for acute reversible pulpitis in routine dental practice., Methods/design: Prospective, observational, open-label, single-arm cohort study., Setting: Eleven dental primary care practices in Germany., Participants and Intervention: Thirty-two patients starting monotherapy with PD for acute reversible pulpitis without visible or radiological abnormalities. PD was applied as 1-mL submucous injections into the mucobuccal fold, repeated daily as needed., Primary Outcome Measures: Avoidance of invasive dental treatment (pulp capping, root canal therapy, tooth extraction) and remission of pain, measured on a 0-10 point scale (partial remission: reduction by > or =3 points; complete remission: reduction from > or =4 points to 0-1 points) during the 10-day follow-up period., Results: Median pain duration was 14.0 days. The patients received a median of two PD applications (range 1-7). A total of 81% (n=26/32) of patients did not require invasive dental treatment, and 19% (n= 6) had root canal therapy. Remission status was evaluable in 24 patients. Of these, 63% (n = 15/24) achieved pain remission, 58% (n = 14) remitted without invasive dental treatment (complete remission: n=12, partial remission: n=2), and 29% (n= 7) had a close temporal relationship between PD and remission (ratio "time to remission after first PD application vs pain duration prior to first PD application" <1:10)., Conclusion: In this study of PD for acute reversible pulpitis, 58% of evaluable patients achieved pain remission without invasive dental treatment. The open-label pre-post design does not allow for conclusions about comparative effectiveness. However, more than one-fourth of evaluable patients remitted with a close temporal relationship between the first PD application and pain remission, suggesting a causal relationship between therapy and remission.

Published
2011

41. Quality of life and neutropenia in patients with early stage breast cancer: a randomized pilot study comparing additional treatment with mistletoe extract to chemotherapy alone.

Author

Tröger W, Jezdić S, Zdrale Z, Tišma N, Hamre HJ, and Matijašević M

Abstract

Background: Chemotherapy for breast cancer often deteriorates quality of life, augments fatigue, and induces neutropenia. Mistletoe preparations are frequently used by cancer patients in Central Europe. Physicians have reported better quality of life in breast cancer patients additionally treated with mistletoe preparations during chemotherapy. Mistletoe preparations also have immunostimulant properties and might therefore have protective effects against chemotherapy-induced neutropenia., Patients and Methods: We conducted a prospective randomized open label pilot study with 95 patients randomized into three groups. Two groups received Iscador® M special (IMS) or a different mistletoe preparation, respectively, additionally to chemotherapy with six cycles of cyclophosphamide, adriamycin, and 5-fluoro-uracil (CAF). A control group received CAF with no additional therapy. Here we report the comparison IMS (n = 30) vs. control (n = 31). Quality of life including fatigue was assessed with the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC-QLQ-C30). Neutropenia was defined as neutrophil counts <1,000/μl and assessed at baseline and one day before each CAF cycle., Results: In the descriptive analysis all 15 scores of the EORTC-QLQ-C30 showed better quality of life in the IMS group compared to the control group. In 12 scores the differences were significant (p < 0.02) and nine scores showed a clinically relevant and significant difference of at least 5 points. Neutropenia occurred in 3/30 IMS patients and in 8/31 control patients (p = 0.182)., Conclusions: This pilot study showed an improvement of quality of life by treating breast cancer patients with IMS additionally to CAF. CAF-induced neutropenia showed a trend to lower frequency in the IMS group.

Published
2009
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42. Local reactions to treatments with Viscum album L. extracts and their association with T-lymphocyte subsets and quality of life.

Author

Büssing A, Tröger W, Stumpf C, and Schietzel M

Subjects
Female, HLA-DR Antigens immunology, Humans, Interleukin-2 Receptor alpha Subunit metabolism, Lymphocyte Activation drug effects, Male, Quality of Life, T-Lymphocytes drug effects, T-Lymphocytes immunology, Antineoplastic Agents, Phytogenic therapeutic use, Neoplasms drug therapy, Neoplasms immunology, Phytotherapy methods, Plant Extracts therapeutic use, Plant Proteins therapeutic use, T-Lymphocyte Subsets drug effects, Viscum album chemistry
Abstract

Background: In a previous study a decline of T-lymphocyte function was observed within a 6-month period of Viscum album extract (VA-E) application which did not occur in those patients with dose adaptation in response to strong local reactions (LR) or in those with moderate LR. To further investigate the immunological prerequisites of these differences in the VA-E susceptibilities, an analysis was carried out of the pre-existing differences in the tumor patients' lymphocyte subsets, and of whether the LR pattern (none, moderate, strong) might be associated with distinct aspects of the patients' quality of life., Patients and Methods: Seventy-one cancer patients were subcutaneously treated with VA-E (Iscador) at increasing concentrations and their lymphocyte subsets measured by flowcytometry during a 6 month observation period; quality of life was assessed with the HLQ questionnaire., Results: The occurrence of stronger LR was associated with a primarily higher level of T-cells and their CD4+ T-helper/inducer subset, and CD25+ respectively HLA-DR+ (activated) T-cells. Moreover, counts or proportions of T-cells, CD4+ T-helper/inducer cells and CD8+ CD28+ cytotoxic cells were lower, while the relative proportions of CD8+ CD28- suppressor cells, B- and NK-cells were the highest in the group with moderate LR. In particular, this latter group had a significantly higher quality of life., Conclusion: Our results indicate that the induction of moderate LR in response to VA-E application was associated with better T cell function and quality of life. Extracts from Viscum album (VA-E) are widely used as a

Published
2008

43. Mistletoe extract reduces the surgical suppression of natural killer cell activity in cancer patients. a randomized phase III trial.

Author

Schink M, Tröger W, Dabidian A, Goyert A, Scheuerecker H, Meyer J, Fischer IU, and Glaser F

Subjects
Aged, Colorectal Neoplasms immunology, Female, Humans, Infusions, Parenteral, Killer Cells, Natural drug effects, Male, Perioperative Care methods, Postoperative Complications immunology, Postoperative Complications prevention & control, Prospective Studies, Treatment Outcome, Colorectal Neoplasms drug therapy, Colorectal Neoplasms surgery, Killer Cells, Natural immunology, Mistletoe chemistry, Phytotherapy, Plant Extracts therapeutic use
Abstract

Background: Major surgery suppresses natural killer (NK) cell cytotoxic activity which is potentially harmful for cancer patients by favouring haematogenic tumour cell dissemination. The influence of a perioperative infusion of a standardized mistletoe extract (Iscador) on immune functions was tested in a prospective, sequential, randomized clinical trial., Patients and Methods: Colorectal cancer patients undergoing open tumour resection were randomly assigned to either mistletoe infusion or no additional therapy. We hypothesized that mistletoe infusion improves NK cell activity and increases expression of MHC class II antigen HLA-DR on monocytes 24 h and 7 days after surgery, respectively. For statistical analysis we used a sequential study design. The decision boundaries for the two triangular tests were calculated for altogether 62 patients., Results: The sequential study design allowed stopping the recruitment prematurely. NK cell activity differed significantly between the therapy groups 24 h after surgery (p = 0.027). The absolute number of HLA-DR molecules on monocytes did not differ 7 days after surgery. NK cell activity of patients treated with mistletoe extract did not change significantly during the course of the study (-7.9% 24 h after surgery), whereas HLA-DR expression changed significantly (-38.5% at day 7 after surgery). For control patients both parameters decreased significantly after surgery (NK cell activity: -44.4% at 24 h; HLA-DR expression: -32.9% at day 7 after surgery)., Conclusion: Perioperative infusion of mistletoe extracts can prevent a suppression of NK cell activity in cancer patients. The impact of this therapy on relapse and survival should be tested in further studies.

Published
2007
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44. [Correlation of NK cell activity against autologous tumour cells and K562 cells with the clinical outcome during therapy with mistletoe extracts].

Author

Schink M, Tröger W, Goyert A, Scheuerecker H, Selbmann HK, and Glaser F

Subjects
Aged, Breast Neoplasms drug therapy, Cohort Studies, Colonic Neoplasms drug therapy, Cytotoxicity, Immunologic, Disease Progression, Female, Humans, K562 Cells, Killer Cells, Natural drug effects, Killer Cells, Natural metabolism, Male, Middle Aged, Plant Extracts therapeutic use, Prospective Studies, Treatment Outcome, Breast Neoplasms immunology, Colonic Neoplasms immunology, Killer Cells, Natural immunology, Mistletoe chemistry, Phytotherapy, Plant Extracts pharmacology
Abstract

Background: Suppression of NK cell activity is considered to be an unfavourable prognostic factor for tumour progression. There is proof that mistletoe extracts may increase NK cell activity. However, the inverse relation between an increase of NK cell activity and clinical progress of cancer has not been investigated., Aim and Design: The relation of NK cell activity and progress of cancer in patients under therapy with mistletoe extracts was examined in a prospective, monocentric, cohort study. At the same time the in vitro killing of K562 cells and autologous tumour cells was compared., Patients and Methods: 40 patients with operable cancer of the breast or colon were included. The patients did not receive any immunologically relevant therapies except for mistletoe extracts. The absolute NK cell count in peripheral blood as well as the in vitro NK cell activity were monitored for up to 2 years and compared with clinical outcome as well as quality of life., Results: The absolute NK cell count in peripheral blood increased within the observation period. Patients without progression had a significantly higher mean activity of NK cells against K562 cells than patients with progression. In the latter group, only stage IV patients showed reduced NK cell activity. The killing activity against autologous tumour cells was <5% in about 77.5% of the patients and could not be evaluated further. The NK cell activity against K562 cells was not related to the number of NK cells., Conclusions: We found a relation between NK cell activity and the progression of malignant disease. In further studies the causality of this relation has to be clarified. The establishment of NK cell activity against autologous tumour cells as a suitable parameter during follow-up was not successful.

Published
2006
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