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16 results on '"Tröger, Birte"'

5. Lactobacillus Acidophilus/Bifidobacterium Infantis Probiotics Are Beneficial to Extremely Low Gestational Age Infants Fed Human Milk

Author

Fortmann, Ingmar, primary, Marißen, Janina, additional, Siller, Bastian, additional, Spiegler, Juliane, additional, Humberg, Alexander, additional, Hanke, Kathrin, additional, Faust, Kirstin, additional, Pagel, Julia, additional, Eyvazzadeh, Leila, additional, Brenner, Kim, additional, Roll, Claudia, additional, Pirr, Sabine, additional, Viemann, Dorothee, additional, Stavropoulou, Dimitra, additional, Henneke, Philipp, additional, Tröger, Birte, additional, Körner, Thorsten, additional, Stein, Anja, additional, Derouet, Christoph, additional, Zemlin, Michael, additional, Wieg, Christian, additional, Rupp, Jan, additional, Herting, Egbert, additional, Göpel, Wolfgang, additional, and Härtel, Christoph, additional

Published
2020
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6. Clinical Relevance of Pathogens Detected by Multiplex PCR in Blood of Very-Low-Birth Weight Infants with Suspected Sepsis – Multicentre Study of the German Neonatal Network

Author

Tröger, Birte, primary, Härtel, Christoph, additional, Buer, Jan, additional, Dördelmann, Michael, additional, Felderhoff-Müser, Ursula, additional, Höhn, Thomas, additional, Hepping, Nico, additional, Hillebrand, Georg, additional, Kribs, Angela, additional, Marissen, Janina, additional, Olbertz, Dirk, additional, Rath, Peter-Michael, additional, Schmidtke, Susanne, additional, Siegel, Jens, additional, Herting, Egbert, additional, Göpel, Wolfgang, additional, Steinmann, Joerg, additional, and Stein, Anja, additional

Published
2016
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7. Risk for Late-onset Blood-culture Proven Sepsis in Very-low-birth Weight Infants Born Small for Gestational Age

Author

Tröger, Birte, primary, Göpel, Wolfgang, additional, Faust, Kirstin, additional, Müller, Thilo, additional, Jorch, Gerhard, additional, Felderhoff-Müser, Ursula, additional, Gortner, Ludwig, additional, Heitmann, Friedhelm, additional, Hoehn, Thomas, additional, Kribs, Angela, additional, Laux, Reinhard, additional, Roll, Claudia, additional, Emeis, Michael, additional, Mögel, Michael, additional, Siegel, Jens, additional, Vochem, Matthias, additional, von der Wense, Axel, additional, Wieg, Christian, additional, Herting, Egbert, additional, and Härtel, Christoph, additional

Published
2014
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12. No mutation in the gene for Noonan syndrome,PTPN11, in 18 patients with Costello syndrome

Author

Tröger, Birte, primary, Kutsche, Kerstin, additional, Bolz, Hanno, additional, Lüttgen, Sabine, additional, Gal, Andreas, additional, Almassy, Zsuzsanna, additional, Caliebe, Almuth, additional, Freisinger, Peter, additional, Hobbiebrunken, Elke, additional, Morlot, Michel, additional, Stefanova, Margarita, additional, Streubel, Berthold, additional, Wieczorek, Dagmar, additional, and Meinecke, Peter, additional

Published
2003
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13. Intrauterine Growth Restriction and the Innate Immune System in Preterm Infants of ≤32 Weeks Gestation.

Author

Tröger, Birte, Müller, Thilo, Faust, Kirstin, Bendiks, Meike, Bohlmann, Michael K., Thonnissen, Susanne, Herting, Egbert, Göpel, Wolfgang, and Härtel, Christoph

Subjects
*PREMATURE infant diseases, *FETAL growth retardation, *IMMUNE system, *IMMUNE response, *GESTATIONAL age, *CYTOKINES
Abstract

Objective: Intrauterine growth restriction (IUGR) is a well-known cause of adverse neonatal outcomes. As it may have an impact on innate immune responses, we aimed to investigate several parameters of the innate immune response in preterm infants of ≤32 weeks gestation who were small for gestational age (SGA). Methods: We compared clinical data of SGA (n = 20) and appropriate for gestational age (AGA; n = 124) newborns with a gestational age of ≤32 weeks. We investigated full blood counts at birth and on days 3 and 7 of life and cytokine immune responses in a human whole cord blood assay. Results: SGA preterm infants had a higher risk of the combined outcome mortality or bronchopulmonary dysplasia. Numbers of white blood cells and neutrophils were diminished in SGA infants at birth and on day 3. At birth, platelet counts were also diminished while the number of nucleated red blood cells tended to be elevated in SGA infants. After stimulation of whole blood cell cultures with lipopolysaccharides, the concentrations of interleukin-6 and interleukin-10 were significantly lower in SGA preterm infants compared to AGA infants. Conclusions: SGA infants differ remarkably from AGA infants in full blood counts and in their ability to mount an immune response. Whether the quantitative deficiency in innate immunity plays a role for adverse outcomes needs to be investigated in larger future trials. Copyright © 2012 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]

Published
2013
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14. The effect of hyperglycemia on neonatal immune responses in-vitro.

Author

Temming, Petra, Tröger, Birte, Thonnissen, Susanne, Holterhus, Paul-martin, Schultz, Christian, and Härtel, Christoph

Subjects
*HYPERGLYCEMIA, *NEWBORN infants, *IMMUNE response, *GLUCOSE, *CYTOKINES
Abstract

Introduction. Acute hyperglycemia is considered as a pro-inflammatory state and is related to an adverse outcome in critically ill adults. Neonates are susceptible to infections and systemic inflammatory response syndrome induced by pro-inflammatory cytokines. This study focuses on the interaction between neonatal glucose homeostasis and the pro-inflammatory cytokine production in term and preterm infants in-vitro. Methods. We analyzed the pro-inflammatory cytokine production in whole cord blood of term infants ( n == 10), preterm infants > 32 weeks ( n==16) and preterm infants ≤32 weeks of gestational age ( n == 13) and in adult controls ( n==14) using an in-vitro sepsis-model. Whole blood was pre-incubated with different concentrations of glucose (0-1000 mg/dl) and insulin (0-62.5 IE/l) and stimulated with lipopolysaccharide. The intracytoplasmatic TNF-α, IL-6, and IL-8 response was measured by flow cytometry. Results. In-vitro hyperglycemia induced a dose-dependent increase of IL-8 in all age groups while TNF-α was demonstrated to be stimulated by glucose in cord blood samples of preterm infants ≤32 weeks of gestational age and term infants. In contrast, insulin showed no significant effects on pro-inflammatory cytokine production in-vitro. Conclusion. Acute hyperglycemia may induce pro-inflammatory cytokine responses in neonatal whole blood in-vitro. These data provide a basis for further in-vitro signal transduction studies and in-vivo investigations about the significance of neonatal glucose homeostasis and its impact on long-term outcome of this susceptible patient cohort. [ABSTRACT FROM AUTHOR]

Published
2012
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16. No mutation in the gene for Noonan syndrome, PTPN11, in 18 patients with Costello syndrome.

Author

Tröger B, Kutsche K, Bolz H, Lüttgen S, Gal A, Almassy Z, Caliebe A, Freisinger P, Hobbiebrunken E, Morlot M, Stefanova M, Streubel B, Wieczorek D, and Meinecke P

Subjects
DNA Mutational Analysis, Humans, Intellectual Disability genetics, Intracellular Signaling Peptides and Proteins, Polymorphism, Single-Stranded Conformational, Protein Tyrosine Phosphatase, Non-Receptor Type 11, Sequence Analysis, DNA, Skin Abnormalities genetics, Syndrome, Abnormalities, Multiple genetics, Noonan Syndrome genetics, Phenotype, Protein Tyrosine Phosphatases genetics
Published
2003
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