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3. Survival Outcomes by Race Following Surgical Treatment for Upper Tract Urothelial Carcinoma

Author

Zappia, Jason, Yong, Courtney, Slaven, James, Wu, Zhenije, Wang, Linhui, Djaladat, Hooman, Wood, Erika, Ghoreifi, Alireza, Abdollah, Firas, Davis, Matthew, Stephens, Alex, Simone, Giuseppe, Tuderti, Gabriele, Gonzalgo, Mark L., Mendiola, Dinno F., Derweesh, Ithaar H., Dhanji, Sohail, Hakimi, Kevin, Margulis, Vitaly, Taylor, Jacob, Ferro, Matteo, Tozzi, Marco, Autorino, Riccardo, Pandolfo, Savio D., Mehrazin, Reza, Eilender, Benjamine, Porpiglia, Francecesco, Checcucci, Enrico, and Sundaram, Chandru P.

Published
2024
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5. PD20-05 REAL-WORLD DATA: CALL FOR PARADIGM SHIFT TOWARDS NEOADJUVANT CHEMOTHERAPY IN PATIENTS WITH UPPER TRACT UROTHELIAL CARCINOMA TREATED WITH NEPHROURETERECTOMY—ANALYSIS OF THE ROBUUST REGISTRY

Author

Tuderti, Gabriele, primary, Proietti, Flavia, additional, Wu, Zhenjie, additional, Franco, Antonio, additional, Wang, Linhui, additional, Margulis, Vitaly, additional, Bhanvadia, Raj, additional, Abdollah, Firas, additional, Finati, Marco, additional, Antonelli, Alessandro, additional, Ditonno, Francesco, additional, Singla, Nirmish, additional, Broenimann, Stephan, additional, Derweesh, Ithaar H., additional, Puri, Dhruv, additional, Rais-Bahrami, Soroush, additional, Moon, Sol C., additional, Ferro, Matteo, additional, Tozzi, Marco, additional, Porpiglia, Francesco, additional, Checcucci, Enrico, additional, Correa, Andreas, additional, Helstrom, Emma, additional, Gonzalgo, Mark L., additional, Mendiola, Dinno F., additional, Perdonà, Sisto, additional, Tufano, Antonio, additional, Eilender, Benjamine M., additional, Mehrazin, Reza, additional, Yong, Courtney, additional, Sundaram, Chandru P., additional, Ghoreifi, Alireza, additional, Djaladat, Hooman, additional, Autorino, Riccardo, additional, and Simone, Giuseppe, additional

Published
2024
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6. Oncological and Functional Outcomes of Penile Shaft Sparing Surgery for Localised Penile Cancer: A Systematic Review

Author

Fallara, Giuseppe, primary, Basile, Giuseppe, additional, Poterek, Adrian, additional, Tozzi, Marco, additional, Pang, Karl H., additional, Çakir, Omer Onur, additional, Bandini, Marco, additional, Ferro, Matteo, additional, Musi, Gennaro, additional, Satchi, Maria, additional, Territo, Angelo, additional, Fankhauser, Christian, additional, and Castiglione, Fabio, additional

Published
2024
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7. DEI-02 SURVIVAL OUTCOMES BY RACE ACROSS DIFFERENT CONTINENTS FOLLOWING MINIMALLY INVASIVE SURGICAL TREATMENT FOR UPPER TRACT UROTHELIAL CARCINOMA: AN ANALYSIS OF THE ROBUUST REGISTRY

Author

Zappia, Jason L., primary, Yong, Courtney, additional, Wu, Zhenjie, additional, Wang, Linhui, additional, Djaladat, Hooman, additional, Wood, Erika, additional, Ghoreifi, Alireza, additional, Abdollah, Firas, additional, Davis, Matthew, additional, Stephens, Alex, additional, Simone, Giuseppe, additional, Tuderti, Gabriele, additional, Gonzalgo, Mark, additional, Mendiola, Dinno, additional, Derweesh, Ithaar, additional, Dhanji, Sohail, additional, Hakimi, Kevin, additional, Margulis, Vitaly, additional, Taylor, Jacob, additional, Ferro, Matteo, additional, Tozzi, Marco, additional, Autorino, Riccardo, additional, Pandolfo, Salvio, additional, Mehrazin, Reza, additional, Eilender, Benjamine, additional, Porpiglia, Francesco, additional, Busacca, Giovanni, additional, Checcucci, Enrico, additional, Eun, Daniel, additional, Bell, Spencer, additional, and Sundaram, Chandru, additional

Published
2024
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8. PD20-06 COMPARATIVE ANALYSIS OF NEOADJUVANT VERSUS ADJUVANT THERAPY FOR UPPER TRACT UROTHELIAL CARCINOMA IN THE SETTING OF CLINICAL NODE POSITIVE DISEASE: ANALYSIS OF THE ROBUUST REGISTRY

Author

Meagher, Margaret F., primary, Wu, Zhenjie, additional, Franco, Antonio, additional, Wang, Linhui, additional, Margulis, Vitaly, additional, Bhanvadia, Raj, additional, Abdollah, Firas, additional, Antonelli, Alessandro, additional, Finati, Marco, additional, Ditonno, Francesco, additional, Singla, Nirmish, additional, Broenimann, Stephan, additional, Simone, Guiseppe, additional, Proietti, Flavia, additional, Tuderti, Gabriele, additional, Pruri, Dhruv, additional, Rais-Bahrami, Soroush, additional, Moon, Sol, additional, Ferro, Matteo, additional, Tozzi, Marco, additional, Porpiglia, Francesco, additional, Amparore, Daniele, additional, Correa, Andreas, additional, Helstrom, Emma, additional, Gonzalgo, Mark, additional, Mendiola, Dinno, additional, Perdonà, Sisto, additional, Tufano, Antonio, additional, Eilander, Benjamin, additional, Mehrazin, Reza, additional, Young, Courtney, additional, Sundaram, Chandru, additional, Ghoreifi, Alireza, additional, Djaladat, Hooman, additional, Autorino, Riccardo, additional, and Derweesh, Ithaar, additional

Published
2024
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9. MP38-17 REAL-WORLD MANAGEMENT OF HIGH-RISK UPPER TRACT UROTHELIAL CARCINOMA: LEVEL OF ADHERENCE TO EAU-AUA GUIDELINES—ANALYSIS OF THE ROBUUST REGISTRY

Author

Tuderti, Gabriele, primary, Proietti, Flavia, additional, Wu, Zhenjie, additional, Franco, Antonio, additional, Wang, Linhui, additional, Margulis, Vitaly, additional, Bhanvadia, Raj, additional, Abdollah, Firas, additional, Finati, Marco, additional, Antonelli, Alessandro, additional, Ditonno, Francesco, additional, Singla, Nirmish, additional, Broenimann, Stephan, additional, Derweesh, Ithaar H., additional, Puri, Dhruv, additional, Rais-Bahrami, Soroush, additional, Moon, Sol C., additional, Ferro, Matteo, additional, Tozzi, Marco, additional, Porpiglia, Francesco, additional, Checcucci, Enrico, additional, Correa, Andreas, additional, Helstrom, Emma, additional, Gonzalgo, Mark L., additional, Mendiola, Dinno F., additional, Perdonà, Sisto, additional, Tufano, Antonio, additional, Eilender, Benjamine M., additional, Mehrazin, Reza, additional, Yong, Courtney, additional, Sundaram, Chandru P., additional, Ghoreifi, Alireza, additional, Djaladat, Hooman, additional, Autorino, Riccardo, additional, and Simone, Giuseppe, additional

Published
2024
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10. The impact of bladder cuff excision on outcomes after nephroureterectomy for upper tract urothelial carcinoma: An analysis of the ROBUUST 2.0 registry

Author

Yong, Courtney, Slaven, James E., Wu, Zhenjie, Margulis, Vitaly, Djaladat, Hooman, Antonelli, Alessandro, Simone, Giuseppe, Bhanvadia, Raj, Ghoreifi, Alireza, Moghaddam, Farshad Sheybaee, Ditonno, Francesco, Tuderti, Gabriele, Bronimann, Stephan, Dhanji, Sohail, Eilender, Benjamin, Franco, Antonio, Finati, Marco, Tozzi, Marco, Helstrom, Emma, Mendiola, Dinno F., Amparore, Daniele, Porpiglia, Francesco, Moon, Sol C., Rais-Bahrami, Soroush, Derweesh, Ithaar, Mehrazin, Reza, Autorino, Riccardo, Abdollah, Firas, Ferro, Matteo, Correa, Andres, Singla, Nirmish, Gonzalgo, Mark L., and Sundaram, Chandru P.

Published
2024
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11. DEVELOPMENT AND VALIDATION OF A NOVEL NOMOGRAM TO PREDICT LYMPH NODE INVASION IN UPPER TRACT UROTHELIAL CARCINOMA

Author

Saitta, Cesare, primary, Afari, Jonathan A., additional, Hakimi, Kevin, additional, Nguyen, Mimi V., additional, Meagher, Margaret F, additional, Wang, Luke, additional, Derweesh, Ithaar H., additional, Autorino, Riccardo, additional, Pandolfo, Savio, additional, Chiarelli, Giuseppe, additional, Abdollah, Firas, additional, Davis, Matthew, additional, Stephens, Alex, additional, Bell, Spencer H., additional, Simone, Giuseppe, additional, Lughezzani, Giovanni, additional, Buffi, Nicolò M., additional, Tuderti, Gabriele, additional, Ferro, Matteo, additional, Yong, Courtney, additional, Sundaram, Chandru P., additional, Tozzi, Marco, additional, Taylor, Jacob, additional, Margulis, Vitaly, additional, Checcucci, Enrico, additional, Porpiglia, Francesco, additional, Wood, Erika, additional, Ghoreifi, Alireza, additional, Djaladat, Hooman, additional, Wang, Linhui, additional, Eilender, Benjamine M., additional, Mehrazin, Reza, additional, Gonzalgo, Mark L., additional, Mendiola, Dinno F., additional, Wu, Zhenjie, additional, and Eun, Daniel D., additional

Published
2024
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13. Oncological Outcomes of Thulium–Yttrium–Aluminum–Garnet (Tm:YAG) Laser Ablation for Penile Cancer

Author

Musi, Gennaro, primary, de Cobelli, Ottavio, additional, Molinari, Filippo, additional, Mistretta, Francesco A., additional, Piccinelli, Mattia Luca, additional, Nardini, Sara, additional, Tozzi, Marco, additional, Bianchi, Roberto, additional, Fontana, Matteo, additional, Di Trapani, Ettore, additional, Cioffi, Antonio, additional, Brescia, Antonio, additional, Cordima, Giovanni, additional, Bottero, Danilo, additional, Ferro, Matteo, additional, Matei, Deliu-Victor, additional, Fusco, Nicola, additional, and Luzzago, Stefano, additional

Published
2023
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15. Penile-Sparing Surgery for Tumour Recurrence after Previous Glansectomy/Partial Penectomy: Treatment Feasibility and Oncological Outcomes

Author

Musi, Gennaro, primary, Molinari, Filippo, additional, Mistretta, Francesco A., additional, Piccinelli, Mattia Luca, additional, Guzzo, Sonia, additional, Tozzi, Marco, additional, Lievore, Elena, additional, Blezien, Oskar, additional, Fontana, Matteo, additional, Cioffi, Antonio, additional, Cullurà, Daniela, additional, Verri, Elena, additional, Cossu Rocca, Maria, additional, Nolè, Franco, additional, Ferro, Matteo, additional, de Cobelli, Ottavio, additional, and Luzzago, Stefano, additional

Published
2023
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17. MP75-10 SURVIVAL OUTCOMES BY RACE FOLLOWING MINIMALLY INVASIVE SURGICAL TREATMENT FOR UPPER TRACT UROTHELIAL CARCINOMA: AN ANALYSIS OF THE ROBUUST REGISTRY

Author

Zappia, Jason, primary, Yong, Courtney, additional, Wu, Zhenije, additional, Wang, Linhui, additional, Djaladat, Hooman, additional, Wood, Erika, additional, Ghoreifi, Alireza, additional, Abdollah, Firas, additional, Davis, Matthew, additional, Stephens, Alex, additional, Simone, Giuseppe, additional, Tuderti, Gabriele, additional, Gonzalgo, Mark, additional, Mendiola, Dinno, additional, Derweesh, Ithaar, additional, Dhanji, Sohail, additional, Hakimi, Kevin, additional, Margulis, Vitaly, additional, Taylor, Jacob, additional, Ferro, Matteo, additional, Tozzi, Marco, additional, Autorino, Riccardo, additional, Pandolfo, Savio, additional, Mehrazin, Reza, additional, Eilender, Benjamine, additional, Porpiglia, Francesco, additional, Checcucci, Enrico, additional, Eun, Daniel, additional, Bell, Spencer, additional, and Sundaram, Chandru, additional

Published
2023
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18. MP47-04 HYPERTENSION IS ASSOCIATED WITH WORSENED ONCOLOGICAL SURVIVAL OUTCOMES IN PATIENTS UNDERGOING NEPHROURETERECTOMY FOR UPPER TRACT UROTHELIAL CARCINOMA: ANALYSIS OF THE ROBUUST REGISTRY

Author

Dhanji, Sohail, primary, Liu, Franklin, additional, Hakimi, Kevin, additional, Djaladat, Hooman, additional, Abdollah, Firas, additional, Gonzalgo, Mark L., additional, Wang, Linhui, additional, Ferro, Matteo, additional, Yong, Courtney, additional, Taylor, Jacob, additional, Pandolfo, Savio D., additional, Porpiglia, Francesco, additional, Checcucci, Enrico, additional, Eilender, Benjamin M., additional, Eun, Daniel D., additional, Bell, Spencer H., additional, Wood, Erika, additional, Ghoreifi, Alireza, additional, Davis, Matthew, additional, Stephens, Alex, additional, Tuderti, Gabriele, additional, Mendiola, Dinno F., additional, Tozzi, Marco, additional, Autorino, Riccardo, additional, Sundaram, Chandru P., additional, Mehrazin, Reza, additional, Margulis, Vitaly, additional, Simone, Giuseppe, additional, Wu, Zhenjie, additional, and Derweesh, Ithaar, additional

Published
2023
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19. MP39-09 RADICAL THERAPY FOR LOW-RISK UPPER TRACT UROTHELIAL CARCINOMA (ROBUUST COLLABORATIVE GROUP)

Author

Corsi, Nick, primary, Morrison, Chase, additional, Davis, Matthew, additional, Stephens, Alex, additional, Rogers, Devin, additional, Tuderti, Gabriele, additional, Mendiola, Dinno F., additional, Wang, Linhui, additional, Checcucci, Enrico, additional, Bell, Spencer H., additional, Yong, Courtney, additional, Dhanji, Sohail, additional, Hakimi, Kevin, additional, Taylor, Jacob, additional, Wood, Erika, additional, Ghoreifi, Alireza, additional, Tozzi, Marco, additional, Eilender, Benjamin M., additional, Sundaram, Chandru, additional, Derweesh, Ithaar H., additional, Margulis, Vitaly, additional, Ferro, Matteo, additional, Simone, Giuseppe, additional, Mehrazin, Reza, additional, Gonzalgo, Mark L., additional, Djaladat, Hooman, additional, Porpiglia, Francesco, additional, Eun, Daniel D., additional, Wu, Zhenjie, additional, Autorino, Riccardo, additional, and Abdollah, Firas, additional

Published
2023
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21. Full activation of thermogenesis in brown adipocytes requires Basigin action

Author

Rupar, Kaja, primary, Isidor, Marie S., additional, Argemi‐Muntadas, Lidia, additional, Agueda‐Oyarzabal, Marina, additional, Plucińska, Kaja, additional, Brown, Erin L., additional, Mattanovich, Matthias, additional, Bossi, Simone, additional, Tozzi, Marco, additional, Tandio, David, additional, Petersen, Patricia S. S., additional, Henriksen, Tora I., additional, Trošt, Kajetan, additional, Hansen, Jacob B., additional, Gerhart‐Hines, Zachary, additional, Nielsen, Søren, additional, Moritz, Thomas, additional, and Emanuelli, Brice, additional

Published
2023
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22. Artificial intelligence and radiomics in evaluation of kidney lesions: a comprehensive literature review

Author

Ferro, Matteo, primary, Crocetto, Felice, additional, Barone, Biagio, additional, del Giudice, Francesco, additional, Maggi, Martina, additional, Lucarelli, Giuseppe, additional, Busetto, Gian Maria, additional, Autorino, Riccardo, additional, Marchioni, Michele, additional, Cantiello, Francesco, additional, Crocerossa, Fabio, additional, Luzzago, Stefano, additional, Piccinelli, Mattia, additional, Mistretta, Francesco Alessandro, additional, Tozzi, Marco, additional, Schips, Luigi, additional, Falagario, Ugo Giovanni, additional, Veccia, Alessandro, additional, Vartolomei, Mihai Dorin, additional, Musi, Gennaro, additional, de Cobelli, Ottavio, additional, Montanari, Emanuele, additional, and Tătaru, Octavian Sabin, additional

Published
2023
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25. Dynamic interplay between Afadin S1795 phosphorylation and diet regulates glucose homeostasis in obese mice

Author

Tozzi, Marco, Brown, Erin L, Petersen, Patricia SS, Lundh, Morten, Isidor, Marie S, Plucińska, Kaja, Nielsen, Thomas S, Agueda‐Oyarzabal, Marina, Small, Lewin, Treebak, Jonas T., Emanuelli, Brice, Tozzi, Marco, Brown, Erin L, Petersen, Patricia SS, Lundh, Morten, Isidor, Marie S, Plucińska, Kaja, Nielsen, Thomas S, Agueda‐Oyarzabal, Marina, Small, Lewin, Treebak, Jonas T., and Emanuelli, Brice

Published
2022

26. Comprehensive overview of ureteral stents based on clinical aspects, material and design.

Author

Bernasconi, Valentina, Tozzi, Marco, Pietropaolo, Amelia, De Coninck, Vincent, Somani, Bhaskar K., Tailly, Thomas, Bres-Niewada, Ewa, Mykoniatis, Ioannis, Gregori, Andrea, and Talso, Michele

Subjects
SURGICAL stents, UROLOGY, URINARY organs, URINARY obstructions, BIOCOMPATIBILITY
Abstract

Ureteral stents are useful devices in urological surgery. The main objective of a ureteric stent is to allow passage of urine and reduce early or late complications related to obstruction in the urinary tract. Despite their widespread use, there is a general lack of knowledge and awareness in stent composition and indication of application. We represented a synthesis of our extensive research over materials, coatings and shapes available on the market and then analyzed the main characteristics and peculiarities of ureteral stents. We have also focused our attention over the side effects and complication that must be considered when placing a ureteral stent. Encrustation, microbial colonization, stent-related symptoms and patient's history must always be evaluated when there is the need for a ureteral stent. The perfect stent should have many characteristics including easy insertion and removal, easy manipulation, resistance to encrustation and migration, lack of complications, biocompatibility, radio-opacity, biodurability, affordability (cost-effectiveness), tolerability and optimal flow characteristics. Nevertheless, further research and studies need to be done to provide more information about stent composition and efficacy in vivo. In this narrative review, we covered the basic information and main characteristics of ureteral stents, in order to help clinicians choose the appropriate device needed for a given situation. [ABSTRACT FROM AUTHOR]

Published
2023
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28. Dynamic interplay between Afadin S1795 phosphorylation and diet regulates glucose homeostasis in obese mice

Author

Tozzi, Marco, primary, Brown, Erin L., additional, Petersen, Patricia S. S., additional, Lundh, Morten, additional, Isidor, Marie S., additional, Plucińska, Kaja, additional, Nielsen, Thomas S., additional, Agueda‐Oyarzabal, Marina, additional, Small, Lewin, additional, Treebak, Jonas T., additional, and Emanuelli, Brice, additional

Published
2021
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30. The P2X7 Receptor Stimulates IL-6 Release from Pancreatic Stellate Cells and Tocilizumab Prevents Activation of STAT3 in Pancreatic Cancer Cells

Author

Magni, Lara, Bouazzi, Rayhana, Heredero Olmedilla, Hugo, Petersen, Patricia S. S., Tozzi, Marco, Novak, Ivana, Magni, Lara, Bouazzi, Rayhana, Heredero Olmedilla, Hugo, Petersen, Patricia S. S., Tozzi, Marco, and Novak, Ivana

Abstract

Pancreatic stellate cells (PSCs) are important pancreatic fibrogenic cells that interact with pancreatic cancer cells to promote the progression of pancreatic ductal adenocarcinoma (PDAC). In the tumor microenvironment (TME), several factors such as cytokines and nucleotides contribute to this interplay. Our aim was to investigate whether there is an interaction between IL-6 and nucleotide signaling, in particular, that mediated by the ATP-sensing P2X7 receptor (P2X7R). Using human cell lines of PSCs and cancer cells, as well as primary PSCs from mice, we show that ATP is released from both PSCs and cancer cells in response to mechanical and metabolic cues that may occur in the TME, and thus activate the P2X7R. Functional studies using P2X7R agonists and inhibitors show that the receptor is involved in PSC proliferation, collagen secretion and IL-6 secretion and it promotes cancer cell migration in a human PSC-cancer cell co-culture. Moreover, conditioned media from P2X7R-stimulated PSCs activated the JAK/STAT3 signaling pathway in cancer cells. The monoclonal antibody inhibiting the IL-6 receptor, Tocilizumab, inhibited this signaling. In conclusion, we show an important mechanism between PSC-cancer cell interaction involving ATP and IL-6, activating P2X7 and IL-6 receptors, respectively, both potential therapeutic targets in PDAC.

Published
2021

32. Proton Pump Inhibitors Reduce Pancreatic Adenocarcinoma Progression by Selectively Targeting H+, K+-ATPases in Pancreatic Cancer and Stellate Cells

Author

Tozzi, Marco, Sørensen, Christiane E., Magni, Lara, Christensen, Nynne M., Bouazzi, Rayhana, Buch, Caroline M., Stefanini, Matteo, Duranti, Claudia, Arcangeli, Annarosa, Novak, Ivana, Tozzi, Marco, Sørensen, Christiane E., Magni, Lara, Christensen, Nynne M., Bouazzi, Rayhana, Buch, Caroline M., Stefanini, Matteo, Duranti, Claudia, Arcangeli, Annarosa, and Novak, Ivana

Abstract

Pancreatic duct cells are equipped with acid/base transporters important for exocrine secretion. Pancreatic ductal adenocarcinoma (PDAC) cells may utilize such transporters to acidify extracellular tumor microenvironment, creating a niche favoring cell proliferation, fibrosis and resistance to chemotherapy—all contributing to the notoriously bad prognosis of this disease. Here, we report that gastric and non-gastric H+, K+-ATPases (coded by ATP4A and ATP12A) are overexpressed in human and murine pancreatic cancer and that we can target them specifically with proton pump inhibitors (PPIs) and potassium-competitive acid blockers (P-CABs) in in vitro models of PDAC. Focusing on pantoprazole, we show that it significantly reduced human cancer cell proliferation by inhibiting cellular H+ extrusion, increasing K+ conductance and promoting cyclin D1-dependent cell cycle arrest and preventing STAT3 activation. Pantoprazole also decreased collagen secretion from pancreatic stellate cells. Importantly, in vivo studies show that pantoprazole treatment of tumor-bearing mice reduced tumor size, fibrosis and expression of angiogenic markers. This work provides the first evidence that H+, K+-ATPases contribute to PDAC progression and that these can be targeted by inhibitors of these pumps, thus proving a promising therapeutic strategy.

Published
2020

33. Next Generation Diabetes Scientists Shape Global Research Culture:A reflective proposal from postdoctoral researchers in diabetes research

Author

Gonzalez-Franquesa, Alba, Carrasquilla Lopez, German Dario, Mamidi, Anant, Ghiasi, Seyed Mojtaba, Juel, Helene Bæk, Falk, Sarah, Isidor, Marie Sophie, Gillberg, Linn Maria Ellinor, Huang, Lam Opal, Quist, Jonas Salling, Knudsen, Jonas Roland, Quaranta, Roberto, Tozzi, Marco, Mikkelsen, Randi Bonke, Dall, Morten, Drag, Markus Hodal, Small, Lewin Barkla, Altıntaş, Ali, Osborne, Brenna, Modvig, Ida Marie, Husted, Anna Sofie, Brown, Erin Louise, Bak, Emilie Glad, Bastos Peluso, Antonio Augusto, Finger, Fabian Michael, Grunddal, Kaare Villum, Rupar, Kaja, Henningsen, Jo Beldring, Pedersen, Maria Hauge, Plucinska, Kaja, Gonzalez-Franquesa, Alba, Carrasquilla Lopez, German Dario, Mamidi, Anant, Ghiasi, Seyed Mojtaba, Juel, Helene Bæk, Falk, Sarah, Isidor, Marie Sophie, Gillberg, Linn Maria Ellinor, Huang, Lam Opal, Quist, Jonas Salling, Knudsen, Jonas Roland, Quaranta, Roberto, Tozzi, Marco, Mikkelsen, Randi Bonke, Dall, Morten, Drag, Markus Hodal, Small, Lewin Barkla, Altıntaş, Ali, Osborne, Brenna, Modvig, Ida Marie, Husted, Anna Sofie, Brown, Erin Louise, Bak, Emilie Glad, Bastos Peluso, Antonio Augusto, Finger, Fabian Michael, Grunddal, Kaare Villum, Rupar, Kaja, Henningsen, Jo Beldring, Pedersen, Maria Hauge, and Plucinska, Kaja

Abstract

The annual Winter School of the Danish Diabetes Academy (DDA) in November 2019 challenged postdoctoral researchers with tough questions regarding research culture that scientists around the world are discussing. The complexity and competitiveness of modern research makes it increasingly difficult for junior researchers to navigate in the science community. This editorial reflects the voices of nearly 200 international researchers ranging from early-career scientists to professors and medical doctors discussing five challenges of modern research culture - and proposes innovative solutions to overcome them.

Published
2020

35. Dynamic interplay between AfadinS1795 phosphorylation and diet regulates glucose homeostasis in obese mice.

Author

Tozzi, Marco, Brown, Erin L., Petersen, Patricia S. S., Lundh, Morten, Isidor, Marie S., Plucińska, Kaja, Nielsen, Thomas S., Agueda‐Oyarzabal, Marina, Small, Lewin, Treebak, Jonas T., and Emanuelli, Brice

Subjects
*INSULIN, *PHOSPHORYLATION, *SCAFFOLD proteins, *GLUCOSE, *ADIPOSE tissues, *HOMEOSTASIS
Abstract

Key points: Afadin is a ubiquitously expressed scaffold protein with a recently discovered role in insulin signalling and glucose metabolism.Insulin‐stimulated phosphorylation of Afadin at S1795 occurs in insulin‐responsive tissues such as adipose tissue, muscle, liver, pancreas and heart.Afadin abundance and AfadinS1795 phosphorylation are dynamically regulated in metabolic tissues during diet‐induced obesity progression.Genetic silencing of AfadinS1795 phosphorylation improves glucose homeostasis in the early stages of diet‐induced metabolic dysregulation.AfadinS1795 phosphorylation contributes to the early development of obesity‐related complications in mice. Obesity is associated with systemic insulin resistance and numerous metabolic disorders. Yet, the mechanisms underlying impaired insulin action during obesity remain to be fully elucidated. Afadin is a multifunctional scaffold protein with the ability to modulate insulin action through its phosphorylation at S1795 in adipocytes. In the present study, we report that insulin‐stimulated AfadinS1795 phosphorylation is not restricted to adipose tissues, but is a common signalling event in insulin‐responsive tissues including muscle, liver, pancreas and heart. Furthermore, a dynamic regulation of Afadin abundance occurred during diet‐induced obesity progression, while its phosphorylation was progressively attenuated. To investigate the role of AfadinS1795 phosphorylation in the regulation of whole‐body metabolic homeostasis, we generated a phospho‐defective mouse model (Afadin SA) in which the Afadin phosphorylation site was silenced (S1795A) at the whole‐body level using CRISPR‐Cas9‐mediated gene editing. Metabolic characterization of these mice under basal physiological conditions or during a high‐fat diet (HFD) challenge revealed that preventing AfadinS1795 phosphorylation improved insulin sensitivity and glucose tolerance and increased liver glycogen storage in the early stage of diet‐induced metabolic dysregulation, without affecting body weight. Together, our findings reveal that AfadinS1795 phosphorylation in metabolic tissues is critical during obesity progression and contributes to promote systemic insulin resistance and glucose intolerance in the early phase of diet‐induced obesity. [ABSTRACT FROM AUTHOR]

Published
2022
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36. Proton Pump Inhibitors Reduce Pancreatic Adenocarcinoma Progression by Selectively Targeting H+, K+-ATPases in Pancreatic Cancer and Stellate Cells

Author

Tozzi, Marco, primary, Sørensen, Christiane E., additional, Magni, Lara, additional, Christensen, Nynne M., additional, Bouazzi, Rayhana, additional, Buch, Caroline M., additional, Stefanini, Matteo, additional, Duranti, Claudia, additional, Arcangeli, Annarosa, additional, and Novak, Ivana, additional

Published
2020
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38. Afadin is a scaffold protein repressing insulin action via HDAC6 in adipose tissue

Author

Lundh, Morten, Petersen, Patricia Ss, Isidor, Marie S, Kazoka-Sørensen, Dolly Nm, Plucińska, Kaja, Shamsi, Farnaz, Ørskov, Cathrine, Tozzi, Marco, Brown, Erin L, Andersen, Emil, Ma, Tao, Müller, Ulrich A., Barrès, Romain, Kristiansen, Viggo B, Gerhart-Hines, Zachary, Tseng, Yu-Hua, Emanuelli, Brice, Lundh, Morten, Petersen, Patricia Ss, Isidor, Marie S, Kazoka-Sørensen, Dolly Nm, Plucińska, Kaja, Shamsi, Farnaz, Ørskov, Cathrine, Tozzi, Marco, Brown, Erin L, Andersen, Emil, Ma, Tao, Müller, Ulrich A., Barrès, Romain, Kristiansen, Viggo B, Gerhart-Hines, Zachary, Tseng, Yu-Hua, and Emanuelli, Brice

Abstract

Insulin orchestrates metabolic homeostasis through a complex signaling network for which the precise mechanisms controlling its fine-tuning are not completely understood. Here, we report that Afadin, a scaffold protein, is phosphorylated on S1795 (S1718 in humans) in response to insulin in adipocytes, and this phosphorylation is impaired with obesity and insulin resistance. In turn, loss of Afadin enhances the response to insulin in adipose tissues via upregulation of the insulin receptor protein levels. This happens in a cell-autonomous and phosphorylation-dependent manner. Insulin-stimulated Afadin-S1795 phosphorylation modulates Afadin binding with interaction partners in adipocytes, among which HDAC6 preferentially interacts with phosphorylated Afadin and acts as a key intermediate to suppress insulin receptor protein levels. Adipose tissue-specific Afadin depletion protects against insulin resistance and improves glucose homeostasis in diet-induced obese mice, independently of adiposity. Altogether, we uncover a novel insulin-induced cellular feedback mechanism governed by the interaction of Afadin with HDAC6 to negatively control insulin action in adipocytes, which may offer new strategies to alleviate insulin resistance.

Published
2019

39. Afadin is a scaffold protein repressing insulin action via HDAC 6 in adipose tissue

Author

Lundh, Morten, primary, Petersen, Patricia SS, additional, Isidor, Marie S, additional, Kazoka‐Sørensen, Dolly NM, additional, Plucińska, Kaja, additional, Shamsi, Farnaz, additional, Ørskov, Cathrine, additional, Tozzi, Marco, additional, Brown, Erin L, additional, Andersen, Emil, additional, Ma, Tao, additional, Müller, Ulrich, additional, Barrès, Romain, additional, Kristiansen, Viggo B, additional, Gerhart‐Hines, Zachary, additional, Tseng, Yu‐Hua, additional, and Emanuelli, Brice, additional

Published
2019
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44. Proton pump inhibitors inhibit pancreatic secretion:role of gastric and non-gastric H+/K+-ATPases

Author

Wang, Jing, Barbuskaite, Dagne, Tozzi, Marco, Giannuzzo, Andrea, Sørensen, Christiane Elisabeth, Novak, Ivana, Wang, Jing, Barbuskaite, Dagne, Tozzi, Marco, Giannuzzo, Andrea, Sørensen, Christiane Elisabeth, and Novak, Ivana

Abstract

The mechanism by which pancreas secretes high HCO3- has not been fully resolved. This alkaline secretion, formed in pancreatic ducts, can be achieved by transporting HCO3- from serosa to mucosa or by moving H+ in the opposite direction. The aim of the present study was to determine whether H+/K+-ATPases are expressed and functional in human pancreatic ducts and whether proton pump inhibitors (PPIs) have effect on those. Here we show that the gastric HKα1 and HKβ subunits (ATP4A; ATP4B) and non-gastric HKα2 subunits (ATP12A) of H+/K+-ATPases are expressed in human pancreatic cells. Pumps have similar localizations in duct cell monolayers (Capan-1) and human pancreas, and notably the gastric pumps are localized on the luminal membranes. In Capan-1 cells, PPIs inhibited recovery of intracellular pH from acidosis. Furthermore, in rats treated with PPIs, pancreatic secretion was inhibited but concentrations of major ions in secretion follow similar excretory curves in control and PPI treated animals. In addition to HCO3-, pancreas also secretes K+. In conclusion, this study calls for a revision of the basic model for HCO3- secretion. We propose that proton transport is driving secretion, and that in addition it may provide a protective pH buffer zone and K+ recirculation. Furthermore, it seems relevant to re-evaluate whether PPIs should be used in treatment therapies where pancreatic functions are already compromised.

Published
2015

46. Partial discharge in power distribution electrical systems: pulse propagation models and detection optimization

Author

Tozzi, Marco <1979>

Subjects
ING-IND/33 Sistemi elettrici per l'energia
Abstract

Investigation on impulsive signals, originated from Partial Discharge (PD) phenomena, represents an effective tool for preventing electric failures in High Voltage (HV) and Medium Voltage (MV) systems. The determination of both sensors and instruments bandwidths is the key to achieve meaningful measurements, that is to say, obtaining the maximum Signal-To-Noise Ratio (SNR). The optimum bandwidth depends on the characteristics of the system under test, which can be often represented as a transmission line characterized by signal attenuation and dispersion phenomena. It is therefore necessary to develop both models and techniques which can characterize accurately the PD propagation mechanisms in each system and work out the frequency characteristics of the PD pulses at detection point, in order to design proper sensors able to carry out PD measurement on-line with maximum SNR. Analytical models will be devised in order to predict PD propagation in MV apparatuses. Furthermore, simulation tools will be used where complex geometries make analytical models to be unfeasible. In particular, PD propagation in MV cables, transformers and switchgears will be investigated, taking into account both irradiated and conducted signals associated to PD events, in order to design proper sensors.

Published
2010

47. Monitoring off-line and on-line PD under impulsive voltage on induction motors - part I: standard procedure

Author

TOZZI, MARCO, CAVALLINI, ANDREA, MONTANARI, GIAN CARLO, M. Tozzi, A. Cavallini, and G. C. Montanari

Subjects
SCARICHE PARZIALI, CONTROLLO DI QUALITÀ, MOTORI ASINCRONI
Abstract

This article is the first of a series of three that examines the correlation between off-line and on-line measurements on Type I random-wound motors. The off-line tests reported in this first article were carried out according to IEC 60034-18-4 to demonstrate that they are PD free under impulsive voltage conditions.

Published
2010

48. Partial discharge assessment in online MV networks: how to interpret results?

Author

CAVALLINI, ANDREA, MONTANARI, GIAN CARLO, TOZZI, MARCO, A. Cavallini, G. C. Montanari, and M. Tozzi

Abstract

This paper focuses on partial discharge detection and analysis for medium voltage distribution system apparatuses. Since the cost structure of the problem dictates that measurement should be performed online, emphasis is given to tools able to (a) remove noise and separate multiple phenomena due to discharges in different apparatuses within the same grid, thus enabling partial discharge source identification, (b) locate a specific source in an environment where cross talk between different apparatuses and/or phases is very common. Eventually, working case will be presented to support the proposed tools.

Published
2010

49. Inception of partial discharges under repetitive square voltages: the effect of voltage waveform and repetition rate on PDIV and RPDIV

Author

CAVALLINI, ANDREA, MONTANARI, GIAN CARLO, TOZZI, MARCO, E. Lindell, A. Cavallini, E. Lindell, G. C. Montanari, and M. Tozzi

Subjects
CONVERTER, PARTIAL DISCHARGES, INVERTER
Abstract

The dependence of partial discharge inception voltage (PDIV) and repetitive partial discharge inception voltage (RPDIV) on some voltage impulse parameters (impulse width, rise time and repetition frequency) is investigated in this paper focusing on crossed pair specimens made of polyimide-amide enameled wires. The results are explained in terms of partial discharge physics and provide basis to improve evaluation during both type and quality tests of random wound motors.

Published
2010

50. Partial discharge measurements and calibration: limits and perspectives for power cables

Author

CAVALLINI, ANDREA, MONTANARI, GIAN CARLO, TOZZI, MARCO, A. Cavallini, G. C. Montanari, and M. Tozzi

Subjects
CALIBRATION, PARTIAL DISCHARGE, APPARENT CHARGE
Abstract

This paper discusses the limits of partial discharge apparent charge estimation focusing on power cables. In particular, the influence of attenuation and propagation phenomena on partial discharge measurement is highlighted, showing that estimates can diverge significantly from the true apparent charge. Reference is also made on UWB and UHF detectors that do not comply with the IEC 60270, but are becoming very popular due to the high signal-to-noise ratios. It will be shown that, depending on noise and interference, some of them can be calibrated, some of them not.

Published
2010

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