188 results on '"Townsend R. R."'
Search Results
2. Review and meta-analysis of renal artery damage following percutaneous renal denervation with radiofrequency renal artery ablation
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Townsend, R, Walton, A, Hettrick, D, Hickey, G, Weil, J, Sharp, A, Blankestijn, P, Bohm, M, Mancia, G, Townsend R. R., Walton A., Hettrick D. A., Hickey G. L., Weil J., Sharp A. S. P., Blankestijn P. J., Bohm M., Mancia G., Townsend, R, Walton, A, Hettrick, D, Hickey, G, Weil, J, Sharp, A, Blankestijn, P, Bohm, M, Mancia, G, Townsend R. R., Walton A., Hettrick D. A., Hickey G. L., Weil J., Sharp A. S. P., Blankestijn P. J., Bohm M., and Mancia G.
- Abstract
Aims: We aimed to estimate the rate of renal artery adverse events following renal denervation with the most commonly applied radiofrequency catheter system based on a comprehensive review of published reports. Methods and results: We reviewed 50 published renal denervation (RDN) trials reporting on procedural safety including 5,769 subjects with 10,249 patient-years of follow-up. Twenty-six patients with renal artery stenosis or dissection (0.45%) were identified of whom 24 (0.41%) required renal artery stenting. The primary meta-analysis of all reports indicated a 0.20% pooled annual incidence rate of stent implantation (95% CI: 0.12 to 0.29% per year). Additional sensitivity analyses yielded consistent pooled estimates (range: 0.17 to 0.42% per year). Median time from RDN procedure to all renal intervention was 5.5 months (range: 0 to 33 months); 79% of all events occurred within one year of the procedure. A separate review of 14 clinical trials reporting on prospective follow-up imaging using either magnetic resonance imaging, computed tomography or angiography following RDN in 511 total subjects identified just 1 new significant stenosis (0.20%) after a median of 11 months post procedure (one to 36 months). Conclusions: Renal artery reintervention following renal denervation with the most commonly applied RF renal denervation system (Symplicity) is rare. Most events were identified within one year.
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- 2021
3. Identification of FUSE-binding protein 1 as a regulatory mRNA-binding protein that represses nucleophosmin translation
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Olanich, M E, Moss, B L, Piwnica-Worms, D, Townsend, R R, and Weber, J D
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- 2011
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4. Mortality and Cardiovascular Disease Among Older Live Kidney Donors
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Reese, P. P., Bloom, R. D., Feldman, H. I., Rosenbaum, P., Wang, W., Saynisch, P., Tarsi, N. M., Mukherjee, N., Garg, A. X., Mussell, A., Shults, J., Even-Shoshan, O., Townsend, R. R., and Silber, J. H.
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- 2014
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5. Change in the pattern of adrenal venous sampling over time in patients with primary aldosteronism
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Murashima, M, Trerotola, S O, Fraker, D L, Han, D, Townsend, R R, and Cohen, D L
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- 2009
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6. Updated American Heart Association/American College of Cardiology; European Society of Hypertension/European Society of Cardiology Guidelines
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Bakris, GL, Sorrentino, MJ, Townsend, R, Mancia, G, Townsend R. R., Mancia G., Bakris, GL, Sorrentino, MJ, Townsend, R, Mancia, G, Townsend R. R., and Mancia G.
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- 2018
7. 0520 Blood Pressure Effects of Positive Airway Pressure Treatment in Obese and Non-obese Adults with Obstructive Sleep Apnea
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Kuna, S T, primary, Townsend, R R, additional, Keenan, B, additional, Maislin, D, additional, Sif Arnardottir, E, additional, Gislason, T, additional, Benediktsdottir, B, additional, Gudmundsdottir, S, additional, Sifferman, A, additional, Staley, B, additional, Pack, F M, additional, Guo, X, additional, Maislin, G, additional, Chirinos, J, additional, and Pack, A I, additional
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- 2018
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8. 1.4: Pulse Wave Velocity and Incident Heart Failure in Chronic Kidney Disease
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Townsend, R. R., Sheridan, A., Strelsin, J., Duckworth, M. J., Chirinos, J. A., Teal, V., Khan, A., Kusek, J., Schreiber, M., Bansal, N., Ojo, A., Lash, J. P., Joffe, M. M., and Investigators, C. R. I. C.
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- 2011
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9. Visit-to-visit offce blood pressure variability and cardiovascular outcomes in SPRINT (systolic blood pressure intervention trial)
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Chang, T, Reboussin, D, Chertow, G, Cheung, A, Cushman, W, Kostis, W, Parati, G, Raj, D, Riessen, E, Shapiro, B, Stergiou, G, Townsend, R, Tsioufs, K, Whelton, P, Whittle, J, Wright, J, Papademetriou, V, Chang T. I., Reboussin D. M., Chertow G. M., Cheung A. K., Cushman W. C., Kostis W. J., Parati G., Raj D., Riessen E., Shapiro B., Stergiou G. S., Townsend R. R., Tsioufs K., Whelton P. K., Whittle J., Wright J. T., Papademetriou V., Chang, T, Reboussin, D, Chertow, G, Cheung, A, Cushman, W, Kostis, W, Parati, G, Raj, D, Riessen, E, Shapiro, B, Stergiou, G, Townsend, R, Tsioufs, K, Whelton, P, Whittle, J, Wright, J, Papademetriou, V, Chang T. I., Reboussin D. M., Chertow G. M., Cheung A. K., Cushman W. C., Kostis W. J., Parati G., Raj D., Riessen E., Shapiro B., Stergiou G. S., Townsend R. R., Tsioufs K., Whelton P. K., Whittle J., Wright J. T., and Papademetriou V.
- Abstract
Studies of visit-to-visit offce blood pressure (BP) variability (OBPV) as a predictor of cardiovascular events and death in high-risk patients treated to lower BP targets are lacking. We conducted a post hoc analysis of SPRINT (Systolic Blood Pressure Intervention Trial), a well-characterized cohort of participants randomized to intensive (<120 mmHg) or standard (<140 mmHg) systolic BP targets. We defned OBPV as the coeffcient of variation of the systolic BP using measurements taken during the 3-,6-, 9-, and 12-month study visits. In our cohort of 7879 participants, older age, female sex, black race, current smoking, chronic kidney disease, and coronary disease were independent determinants of higher OBPV. Use of thiazide-type diuretics or dihydropyridine calcium channel blockers was associated with lower OBPV whereas angiotensin-converting enzyme inhibitors or angiotensin receptor blocker use was associated with higher OBPV. There was no difference in OBPV in participants randomized to standard or intensive treatment groups. We found that OBPV had no signifcant associations with the composite end point of fatal and nonfatal cardiovascular events (n=324 primary end points; adjusted hazard ratio, 1.20; 95% confdence interval, 0.85-1.69, highest versus lowest quintile) nor with heart failure or stroke. The highest quintile of OBPV (versus lowest) was associated with all-cause mortality (adjusted hazard ratio, 1.92; confdence interval, 1.22-3.03) although the association of OBPV overall with all-cause mortality was marginal (P=0.07). Our results suggest that clinicians should continue to focus on offce BP control rather than on OBPV unless defnitive benefts of reducing OBPV are shown in prospective trials.
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- 2017
10. Validation of non-invasive central blood pressure devices: Artery society task force (abridged) consensus statement on protocol standardization
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Sharman, J, Avolio, A, Baulmann, J, Benetos, A, Blacher, J, Blizzard, C, Boutouyrie, P, Chen, C, Chowienczyk, P, Cockcroft, J, Cruickshank, J, Ferreira, I, Ghiadoni, L, Hughes, A, Jankowski, P, Laurent, S, Mcdonnell, B, Mceniery, C, Millasseau, S, Papaioannou, T, Parati, G, Park, J, Protogerou, A, Roman, M, Schillaci, G, Segers, P, Stergiou, G, Tomiyama, H, Townsend, R, Van Bortel, L, Wang, J, Wassertheurer, S, Weber, T, Wilkinson, I, Vlachopoulos, C, Sharman J. E., Avolio A. P., Baulmann J., Benetos A., Blacher J., Blizzard C. L., Boutouyrie P., Chen C. -H., Chowienczyk P., Cockcroft J. R., Cruickshank J. K., Ferreira I., Ghiadoni L., Hughes A., Jankowski P., Laurent S., McDonnell B. J., McEniery C., Millasseau S. C., Papaioannou T. G., Parati G., Park J. B., Protogerou A. D., Roman M. J., Schillaci G., Segers P., Stergiou G. S., Tomiyama H., Townsend R. R., Van Bortel L. M., Wang J., Wassertheurer S., Weber T., Wilkinson I. B., Vlachopoulos C., Sharman, J, Avolio, A, Baulmann, J, Benetos, A, Blacher, J, Blizzard, C, Boutouyrie, P, Chen, C, Chowienczyk, P, Cockcroft, J, Cruickshank, J, Ferreira, I, Ghiadoni, L, Hughes, A, Jankowski, P, Laurent, S, Mcdonnell, B, Mceniery, C, Millasseau, S, Papaioannou, T, Parati, G, Park, J, Protogerou, A, Roman, M, Schillaci, G, Segers, P, Stergiou, G, Tomiyama, H, Townsend, R, Van Bortel, L, Wang, J, Wassertheurer, S, Weber, T, Wilkinson, I, Vlachopoulos, C, Sharman J. E., Avolio A. P., Baulmann J., Benetos A., Blacher J., Blizzard C. L., Boutouyrie P., Chen C. -H., Chowienczyk P., Cockcroft J. R., Cruickshank J. K., Ferreira I., Ghiadoni L., Hughes A., Jankowski P., Laurent S., McDonnell B. J., McEniery C., Millasseau S. C., Papaioannou T. G., Parati G., Park J. B., Protogerou A. D., Roman M. J., Schillaci G., Segers P., Stergiou G. S., Tomiyama H., Townsend R. R., Van Bortel L. M., Wang J., Wassertheurer S., Weber T., Wilkinson I. B., and Vlachopoulos C.
- Abstract
Brachial cuff blood pressure (BP) is clinically important, but may be an inaccurate substitute for central BP. Many non-invasive devices have been developed that purport to estimate central BP from peripheral artery sites, yet with no standardized guidelines; the accuracy testing of these new devices has not been undertaken in a uniform fashion with comparable protocols. This is an abridged paper describing the recommendations reached by an international task force convened to identify issues that need to be addressed and reach consensus relating to methods for assessing and reporting the accuracy (validation) of central BP devices. The recommendations are endorsed by the Association for Research into Arterial Structure and Physiology (ARTERY) Society, as well as the European Society of Hypertension (ESH) Working Group on Arterial Structure and Function, and the ESH Working Group on Blood Pressure Monitoring and Cardiovascular Variability. Researchers interested in validating central BP monitors should read the full version of the statement.
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- 2017
11. S9.15 Structural elucidation ofO-Glycosylation on Glycoproteins
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Townsend, R. R., Medzihradszky, K. F., Reinders, L., and Burlingame, A. L.
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- 1993
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12. S9.17 Structural studies on the glycosylation of the gastric H+, K+-ATpase
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Lipniunas, P. H., Tyagarajan, K., Chow, D., Forte, J. G., and Townsend, R. R.
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- 1993
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13. Genetic studies of body mass index yield new insights for obesity biology
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Locke, A, Kahali, B, Berndt, S, Justice, A, Pers, T, Day, F, Powell, C, Vedantam, S, Buchkovich, M, Yang, J, Croteau-Chonka, D, Esko, T, Fall, T, Ferreira, T, Gustafsson, S, Kutalik, Z, Luan, J, Magi, R, Randall, J, Winkler, T, Wood, A, Workalemahu, T, Faul, J, Smith, J, Zhao, J, Zhao, W, Chen, J, Fehrmann, R, Hedman, A, Karjalainen, J, Schmidt, E, Absher, D, Amin, N, Anderson, D, Beekman, M, Bolton, J, Bragg-Gresham, J, Buyske, S, Demirkan, A, Deng, G, Ehret, G, Feenstra, B, Feitosa, M, Fischer, K, Goel, A, Gong, J, Jackson, A, Kanoni, S, Kleber, M, Kristiansson, K, Lim, U, Lotay, V, Mangino, M, Leach, I, Medina-Gomez, C, Medland, S, Nalls, M, Palmer, C, Pasko, D, Pechlivanis, S, Peters, M, Prokopenko, I, Shungin, D, Stancakova, A, Strawbridge, R, Sung, Y, Tanaka, T, Teumer, A, Trompet, S, van der Laan, S, van Setten, J, Van Vliet-Ostaptchouk, J, Wang, Z, Yengo, L, Zhang, W, Isaacs, A, Albrecht, E, Arnlov, J, Arscott, G, Attwood, A, Bandinelli, S, Barrett, A, Bas, I, Bellis, C, Bennett, A, Berne, C, Blagieva, R, Bluher, M, Bohringer, S, Bonnycastle, L, Bottcher, Y, Boyd, H, Bruinenberg, M, Caspersen, I, Chen, Y, Clarke, R, Daw, E, de Craen, A, Delgado, G, Dimitriou, M, Doney, A, Eklund, N, Estrada, K, Eury, E, Folkersen, L, Fraser, R, Garcia, M, Geller, F, Giedraitis, V, Gigante, B, Go, A, Golay, A, Goodall, A, Gordon, S, Gorski, M, Grabe, H, Grallert, H, Grammer, T, Grassler, J, Gronberg, H, Groves, C, Gusto, G, Haessler, J, Hall, P, Haller, T, Hallmans, G, Hartman, C, Hassinen, M, Hayward, C, Heard-Costa, N, Helmer, Q, Hengstenberg, C, Holmen, O, Hottenga, J, James, A, Jeff, J, Johansson, A, Jolley, J, Juliusdottir, T, Kinnunen, L, Koenig, W, Koskenvuo, M, Kratzer, W, Laitinen, J, Lamina, C, Leander, K, Lee, N, Lichtner, P, Lind, L, Lindstrom, J, Lo, K, Lobbens, S, Lorbeer, R, Lu, Y, Mach, F, Magnusson, P, Mahajan, A, Mcardle, W, Mclachlan, S, Menni, C, Merger, S, Mihailov, E, Milani, L, Moayyeri, A, Monda, K, Morken, M, Mulas, A, Muller, G, Muller-Nurasyid, M, Musk, A, Nagaraja, R, Nothen, M, Nolte, I, Pilz, S, Rayner, N, Renstrom, F, Rettig, R, Ried, J, Ripke, S, Robertson, N, Rose, L, Sanna, S, Scharnagl, H, Scholtens, S, Schumacher, F, Scott, W, Seufferlein, T, Shi, J, Smith, A, Smolonska, J, Stanton, A, Steinthorsdottir, V, Stirrups, K, Stringham, H, Sundstrom, J, Swertz, M, Swift, A, Syvanen, A, Tan, S, Tayo, B, Thorand, B, Thorleifsson, G, Tyrer, J, Uh, H, Vandenput, L, Verhulst, F, Vermeulen, S, Verweij, N, Vonk, J, Waite, L, Warren, H, Waterworth, D, Weedon, M, Wilkens, L, Willenborg, C, Wilsgaard, T, Wojczynski, M, Wong, A, Wright, A, Zhang, Q, Brennan, E, Choi, M, Dastani, Z, Drong, A, Eriksson, P, Franco-Cereceda, A, Gadin, J, Gharavi, A, Goddard, M, Handsaker, R, Huang, J, Karpe, F, Kathiresan, S, Keildson, S, Kiryluk, K, Kubo, M, Lee, J, Liang, L, Lifton, R, Ma, B, Mccarroll, S, Mcknight, A, Min, J, Moffatt, M, Montgomery, G, Murabito, J, Nicholson, G, Nyholt, D, Okada, Y, Perry, J, Dorajoo, R, Reinmaa, E, Salem, R, Sandholm, N, Scott, R, Stolk, L, Takahashi, A, Van't Hooft, F, Vinkhuyzen, A, Westra, H, Zheng, W, Zondervan, K, Heath, A, Arveiler, D, Bakker, S, Beilby, J, Bergman, R, Blangero, J, Bovet, P, Campbell, H, Caulfield, M, Cesana, G, Chakravarti, A, Chasman, D, Chines, P, Collins, F, Crawford, D, Cupples, L, Cusi, D, Danesh, J, de Faire, U, Den Ruijter, H, Dominiczak, A, Erbel, R, Erdmann, J, Eriksson, J, Farrall, M, Felix, S, Ferrannini, E, Ferrieres, J, Ford, I, Forouhi, N, Forrester, T, Franco, O, Gansevoort, R, Gejman, P, Gieger, C, Gottesman, O, Gudnason, V, Gyllensten, U, Hall, A, Harris, T, Hattersley, A, Hicks, A, Hindorff, L, Hingorani, A, Hofman, A, Homuth, G, Hovingh, G, Humphries, S, Hunt, S, Hypponen, E, Illig, T, Jacobs, K, Jarvelin, M, Jockel, K, Johansen, B, Jousilahti, P, Jukema, J, Jula, A, Kaprio, J, Kastelein, J, Keinanen-Kiukaanniemi, S, Kiemeney, L, Knekt, P, Kooner, J, Kooperberg, C, Kovacs, P, Kraja, A, Kumari, M, Kuusisto, J, Lakka, T, Langenberg, C, Marchand, L, Lehtimaki, T, Lyssenko, V, Mannisto, S, Marette, A, Matise, T, Mckenzie, C, Mcknight, B, Moll, F, Morris, A, Murray, J, Nelis, M, Ohlsson, C, Oldehinkel, A, Ong, K, Madden, P, Pasterkamp, G, Peden, J, Peters, A, Postma, D, Pramstaller, P, Price, J, Qi, L, Raitakari, O, Rankinen, T, Rao, D, Rice, T, Ridker, P, Rioux, J, Ritchie, M, Rudan, I, Salomaa, V, Samani, N, Saramies, J, Sarzynski, M, Schunkert, H, Schwarz, P, Sever, P, Shuldiner, A, Sinisalo, J, Stolk, R, Strauch, K, Tonjes, A, Tregouet, D, Tremblay, A, Tremoli, E, Virtamo, J, Vohl, M, Volker, U, Waeber, G, Willemsen, G, Witteman, J, Zillikens, M, Adair, L, Amouyel, P, Asselbergs, F, Assimes, T, Bochud, M, Boehm, B, Boerwinkle, E, Bornstein, S, Bottinger, E, Bouchard, C, Cauchi, S, Chambers, J, Chanock, S, Cooper, R, de Bakker, P, Dedoussis, G, Ferrucci, L, Franks, P, Froguel, P, Groop, L, Haiman, C, Hamsten, A, Hui, J, Hunter, D, Hveem, K, Kaplan, R, Kivimaki, M, Kuh, D, Laakso, M, Liu, Y, Martin, N, Marz, W, Melbye, M, Metspalu, A, Moebus, S, Munroe, P, Njolstad, I, Oostra, B, Pedersen, N, Perola, M, Perusse, L, Peters, U, Power, C, Quertermous, T, Rauramaa, R, Rivadeneira, F, Saaristo, T, Saleheen, D, Sattar, N, Schadt, E, Schlessinger, D, Slagboom, P, Snieder, H, Spector, T, Thorsteinsdottir, U, Stumvoll, M, Tuomilehto, J, Uitterlinden, A, Uusitupa, M, van der Harst, P, Walker, M, Wallaschofski, H, Wareham, N, Watkins, H, Weir, D, Wichmann, H, Wilson, J, Zanen, P, Borecki, I, Deloukas, P, Fox, C, Heid, I, O'Connell, J, Strachan, D, Stefansson, K, van Duijn, C, Abecasis, G, Franke, L, Frayling, T, Mccarthy, M, Visscher, P, Scherag, A, Willer, C, Boehnke, M, Mohlke, K, Lindgren, C, Beckmann, J, Barroso, I, North, K, Ingelsson, E, Hirschhorn, J, Loos, R, Speliotes, E, Thompson, J, Goldstein, B, Konig, I, Cazier, J, Grundberg, E, Havulinna, A, Ho, W, Hopewell, J, Eriksson, N, Lundmark, P, Lyytikainen, L, Rafelt, S, Tikkanen, E, Van Zuydam, N, Voight, B, Ziegler, A, Altshuler, D, Balmforth, A, Braund, P, Burgdorf, C, Claudi-Boehm, S, Cox, D, Do, R, El Mokhtari, N, Fontanillas, P, Hager, J, Han, B, Kang, H, Kessler, T, Knowles, J, Kolovou, G, Langford, C, Lokki, M, Lundmark, A, Meisinger, C, Melander, O, Maouche, S, Nikus, K, Rasheed, A, Rosinger, S, Rubin, D, Rumpf, M, Schafer, A, Sivananthan, M, Song, C, Stewart, A, Thorgeirsson, G, van der Schoot, C, Wagner, P, Wells, G, Wild, P, Tsun-Po, Y, Basart, H, Brambilla, P, Cambien, F, Cupples, A, Dehghan, A, Diemert, P, Epstein, S, Evans, A, Ferrario, M, Gauguier, D, Hazen, S, Holm, H, Iribarren, C, Jang, Y, Kahonen, M, Kee, F, Kim, H, Klopp, N, Kuulasmaa, K, Laaksonen, R, Ouwehand, W, Parish, S, Park, J, Rader, D, Shah, S, Stark, K, Wallentin, L, Zimmermann, M, Nieminen, M, Sandhu, M, Pastinen, T, Zalloua, P, Siegbahn, A, Schreiber, S, Ripatti, S, Blankenberg, S, O'Donnell, C, Reilly, M, Collins, R, Roberts, R, Pattaro, C, Kottgen, A, Garnaas, M, Boger, C, Fuchsberger, C, Olden, M, Chen, M, Tin, A, Taliun, D, Li, M, Gao, X, Yang, Q, Hundertmark, C, Foster, M, O'Seaghdha, C, Glazer, N, Liu, C, Struchalin, M, Li, G, Johnson, A, Gierman, H, Hwang, S, Atkinson, E, Lohman, K, Cornelis, M, Chouraki, V, Holliday, E, Sorice, R, Deshmukh, H, Ulivi, S, Chu, A, Murgia, F, Imboden, M, Kollerits, B, Pistis, G, Launer, L, Aspelund, T, Eiriksdottir, G, Mitchell, B, Schmidt, H, Cavalieri, M, Rao, M, Hu, F, de Andrade, M, Turner, S, Ding, J, Andrews, J, Freedman, B, Doring, A, Kolcic, I, Zemunik, T, Boban, M, Minelli, C, Wheeler, H, Igl, W, Zaboli, G, Wild, S, Ellinghaus, D, Nothlings, U, Jacobs, G, Biffar, R, Endlich, K, Ernst, F, Kroemer, H, Nauck, M, Stracke, S, Volzke, H, Aulchenko, Y, Polasek, O, Hastie, N, Vitart, V, Helmer, C, Wang, J, Ruggiero, D, Bergmann, S, Viikari, J, Nikopensius, T, Province, M, Ketkar, S, Colhoun, H, Robino, A, Giulianini, F, Kramer, B, Portas, L, Buckley, B, Adam, M, Thun, G, Paulweber, B, Haun, M, Sala, C, Metzger, M, Mitchell, P, Ciullo, M, Kim, S, Vollenweider, P, Gasparini, P, Pirastu, M, Probst-Hensch, N, Kronenberg, F, Toniolo, D, Coresh, J, Schmidt, R, Siscovick, D, Kardia, S, Curhan, G, Franke, A, Parsa, A, Goessling, W, Kao, W, de Boer, I, Peralta, C, Akylbekova, E, Kramer, H, Arking, D, Franceschini, N, Egan, J, Hernandez, D, Townsend, R, Lumley, T, Psaty, B, Kestenbaum, B, Haritunians, T, Mooser, V, Florez, J, Meigs, J, Lu, X, Leak, T, Aasarod, K, Skorpen, F, Baumert, J, Devuyst, O, Mychaleckyj, J, Kedenko, L, Coassin, S, Hallan, S, Navis, G, Shlipak, M, Bull, S, Paterson, A, Rotter, J, Dreisbach, A, Anderson, C, Guo, Q, Henders, A, Lambert, A, Lee, S, Kraft, P, Kennedy, S, Macgregor, S, Missmer, S, Painter, J, Roseman, F, Treloar, S, Wallace, L, Forsblom, C, Isakova, T, Mckay, G, Williams, W, Sadlier, D, Makinen, V, Swan, E, Boright, A, Ahlqvist, E, Keller, B, Huang, H, Ahola, A, Fagerholm, E, Gordin, D, Harjutsalo, V, He, B, Heikkila, O, Hietala, K, Kyto, J, Lahermo, P, Lehto, M, Osterholm, A, Parkkonen, M, Pitkaniemi, J, Rosengard-Barlund, M, Saraheimo, M, Sarti, C, Soderlund, J, Soro-Paavonen, A, Syreeni, A, Thorn, L, Tikkanen, H, Tolonen, N, Tryggvason, K, Waden, J, Gill, G, Prior, S, Guiducci, C, Mirel, D, Taylor, A, Hosseini, M, Parving, H, Rossing, P, Tarnow, L, Ladenvall, C, Alhenc-Gelas, F, Lefebvre, P, Rigalleau, V, Roussel, R, Maestroni, A, Maestroni, S, Falhammar, H, Gu, T, Mollsten, A, Cimponeriu, D, Mihai, I, Mota, M, Mota, E, Serafinceanu, C, Stavarachi, M, Hanson, R, Nelson, R, Kretzler, M, Panduru, N, Gu, H, Brismar, K, Zerbini, G, Hadjadj, S, Marre, M, Lajer, M, Waggott, D, Savage, D, Bain, S, Martin, F, Godson, C, Groop, P, Maxwell, A, Sengupta, S, Peloso, G, Ganna, A, Mora, S, Chang, H, Den Hertog, H, Donnelly, L, Freitag, D, Gurdasani, D, Heikkila, K, Johnson, T, Kaakinen, M, Kettunen, J, Li, X, Montasser, M, Petersen, A, Saxena, R, Service, S, Sidore, C, Surakka, I, Teslovich, T, Van den Herik, E, Volcik, K, Wu, Y, Asiki, G, Been, L, Burnett, M, Elliott, P, Eyjolfsson, G, Goodarzi, M, Gravito, M, Hartikainen, A, Hung, 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E., Schlessinger D., Slagboom P. E., Snieder H., Spector T. D., Thorsteinsdottir U., Stumvoll M., Tuomilehto J., Uitterlinden A. G., Uusitupa M., van der Harst P., Walker M., Wallaschofski H., Wareham N. J., Watkins H., Weir D. R., Wichmann H. E., Wilson J. F., Zanen P., Borecki I. B., Deloukas P., Fox C. S., Heid I. M., O'connell J. R., Strachan D. P., Stefansson K., van Duijn C. M., Abecasis G. R., Franke L., Frayling T. M., McCarthy M. I., Visscher P. M., Scherag A., Willer C. J., Boehnke M., Mohlke K. L., Lindgren C. M., Beckmann J. S., Barroso I., North K. E., Ingelsson E., Hirschhorn J. N., Loos R. J. F., Speliotes E. K., Thompson J. R., Goldstein B. A., Konig I. R., Cazier J. B., Grundberg E., Havulinna A. S., Ho W. K., Hopewell J. C., Eriksson N., Lundmark P., Lyytikainen L. P., Rafelt S., Tikkanen E., Van Zuydam N., Voight B. F., Ziegler A., Altshuler D., Balmforth A. J., Braund P. S., Burgdorf C., Claudi-Boehm S., Cox D., Do R., Doney A. S., El Mokhtari N., Fontanillas P., Hager J., Han B. G., Hunt S. E., Kang H. M., Kessler T., Knowles J. W., Kolovou G., Langford C., Lokki M. L., Lundmark A., Meisinger C., Melander O., Maouche S., Nikus K., Rasheed A., Rosinger S., Rubin D., Rumpf M. P., Schafer A., Sivananthan M., Song C., Stewart A. F., Thorgeirsson G., van der Schoot C. E., Wagner P. J., Wells G. A., Wild P. S., Tsun-Po Y., Basart H. V., Brambilla P., Cambien F., Cupples A. L., Dehghan A., Diemert P., Epstein S. E., Evans A., Ferrario M., Gauguier D., Hazen S. L., Holm H., Iribarren C., Jang Y., Kahonen M., Kee F., Kim H. S., Klopp N., Kuulasmaa K., Laaksonen R., Ouwehand W. H., Parish S., Park J. E., Rader D. J., Shah S. H., Stark K., Wallentin L., Zimmermann M. E., Nieminen M. S., Sandhu M. S., Pastinen T., Zalloua P. A., Siegbahn A., Schreiber S., Ripatti S., Blankenberg S. S., O'donnell C. J., Reilly M., Collins R., Roberts R., Pattaro C., Kottgen A., Garnaas M., Boger C. A., Fuchsberger C., Olden M., Chen M. H., Tin A., Taliun D., Li M., Gao X., Yang Q., Hundertmark C., Foster M. C., O'seaghdha C. M., Glazer N. L., Liu C. T., Struchalin M., Li G., Johnson A. D., Gierman H. J., Hwang S. J., Atkinson E. J., Lohman K. K., Cornelis M. C., Chouraki V., Holliday E. G., Sorice R., Deshmukh H., Ulivi S., Chu A. Y., Murgia F., Imboden M., Kollerits B., Pistis G., Launer L. J., Aspelund T., Eiriksdottir G., Mitchell B. D., Schmidt H., Cavalieri M., Rao M., Hu F. B., de Andrade M., Turner S. T., Ding J., Andrews J. S., Freedman B. I., Doring A., Kolcic I., Zemunik T., Boban M., Minelli C., Wheeler H. E., Igl W., Zaboli G., Wild S. H., Ellinghaus D., Nothlings U., Jacobs G., Biffar R., Endlich K., Ernst F., Kroemer H. K., Nauck M., Stracke S., Volzke H., Aulchenko Y., Polasek O., Hastie N. D., Vitart V., Helmer C., Wang J. J., Ruggiero D., Bergmann S., Viikari J., Nikopensius T., Province M. A., Ketkar S., Colhoun H. M., Doney A., Robino A., Giulianini F., Kramer B. K., Portas L., Buckley B. M., Adam M., Thun G. A., Paulweber B., Haun M., Sala C., Metzger M., Mitchell P., Ciullo M., Kim S. K., Vollenweider P., Palmer C., Gasparini P., Pirastu M., Probst-Hensch N. M., Kronenberg F., Toniolo D., Coresh J., Schmidt R., Siscovick D. S., Kardia S. L., Curhan G., Franke A., Parsa A., Goessling W., Kao W. H., de Boer I. H., Peralta C. A., Akylbekova E., Kramer H., Arking D. E., Franceschini N., Egan J., Hernandez D. G., Townsend R. R., Lumley T., Psaty B. M., Kestenbaum B., Haritunians T., Mooser V., Florez J. C., Meigs J. B., Lu X., Leak T. S., Aasarod K., Skorpen F., Baumert J., Devuyst O., Mychaleckyj J. C., Kedenko L., Coassin S., Hallan S., Navis G., Shlipak M. G., Bull S. B., Paterson A. D., Rotter J. I., Dreisbach A. W., Anderson C. A., Guo Q., Henders A., Lambert A., Lee S. H., Kraft P., Kennedy S. H., Macgregor S., Missmer S. A., Painter J. N., Roseman F., Treloar S. A., Wallace L., Forsblom C., Isakova T., McKay G. J., Williams W. W., Sadlier D. M., Makinen V. P., Swan E. J., Boright A. P., Ahlqvist E., Keller B. J., Huang H., Ahola A., Fagerholm E., Gordin D., Harjutsalo V., He B., Heikkila O., Hietala K., Kyto J., Lahermo P., Lehto M., Osterholm A. M., Parkkonen M., Pitkaniemi J., Rosengard-Barlund M., Saraheimo M., Sarti C., Soderlund J., Soro-Paavonen A., Syreeni A., Thorn L. M., Tikkanen H., Tolonen N., Tryggvason K., Waden J., Gill G. V., Prior S., Guiducci C., Mirel D. B., Taylor A., Hosseini M., Parving H. H., Rossing P., Tarnow L., Ladenvall C., Alhenc-Gelas F., Lefebvre P., Rigalleau V., Roussel R., Maestroni A., Maestroni S., Falhammar H., Gu T., Mollsten A., Cimponeriu D., Mihai I., Mota M., Mota E., Serafinceanu C., Stavarachi M., Hanson R. L., Nelson R. G., Kretzler M., Panduru N. M., Gu H. F., Brismar K., Zerbini G., Hadjadj S., Marre M., Lajer M., Waggott D., Savage D. A., Bain S. C., Martin F., Godson C., Groop P. H., Maxwell A. P., Sengupta S., Peloso G. M., Ganna A., Mora S., Chang H. Y., Den Hertog H. M., Donnelly L. A., Freitag D. F., Gurdasani D., Heikkila K., Johnson T., Kaakinen M., Kettunen J., Li X., Montasser M. E., Petersen A. K., Saxena R., Service S. K., Sidore C., Surakka I., Teslovich T. M., Van den Herik E. G., Volcik K. A., Wu Y., Asiki G., Been L. F., Burnett M. S., Elliott P., Eyjolfsson G. I., Goodarzi M. O., Gravito M. L., Hartikainen A. L., Hung Y. J., Jones M. R., Kaleebu P., Khaw K. T., Kim E., Komulainen P., Lin S. Y., Narisu N., Nieminen T. V., Nsubuga R. N., Olafsson I., Palotie A., Papamarkou T., Pomilla C., Pouta A., Ruokonen A., Seeley J., Silander K., Tiret L., van Pelt L., Wainwright N., Wijmenga C., Young E. H., Bennett F., Boomsma D. I., Burnier M., Chen Y. D., Feranil A. B., Freimer N. B., Hsiung C. A., Kesaniemi A., Koudstaal P. J., Krauss R. M., Kyvik K. O., Meneton P., Moilanen L., Sanghera D. K., Sheu W. H., Whitfield J. B., Wolffenbuttel B. H., Ordovas J. M., Rich S. S., Johnson A., Johnson L., Larson M., Levy D., Newton-Cheh C., O'reilly P., Palmas W., Rice K., Smith A., Snider H., Tobin M., Verwoert G., Rice K. M., Verwoert G. C., Pihur V., Heath S., Sober S., Arora P., Zhang F., Lucas G., Milaneschi Y., Parker A. N., Fava C., Fox E. R., Go M. J., Sjogren M., Vinay D., Alexander M., Tabara Y., Shaw-Hawkins S., Whincup P. H., Shi G., Seielstad M., Sim X., Nguyen K. D., Matullo G., Gaunt T. R., Onland-Moret N. C., Cooper M. N., Platou C. G., Org E., Hardy R., Dahgam S., Palmen J., Kuznetsova T., Uiterwaal C. S., Adeyemo A., Ludwig B., Tomaszewski M., Tzoulaki I., Palmer N. D., Chang Y. P., Steinle N. I., Grobbee D. E., Morrison A. C., Najjar S., Hadley D., Brown M. J., Connell J. M., Day I. N., Lawlor D. A., Lawrence R. W., Ongen H., Li Y., Young J. H., Bis J. C., Bolton J. A., Chaturvedi N., Islam M., Jafar T. H., Kulkarni S. R., Howard P., Guarrera S., Ricceri F., Emilsson V., Plump A., Weder A. B., Sun Y. V., Scott L. J., Peltonen L., Vartiainen E., Brand S. M., Staessen J. A., Wang T. J., Burton P. R., Artigas M. S., Dong Y., Wang X., Zhu H., Rudock M. E., Heckbert S. R., Smith N. L., Wiggins K. L., Doumatey A., Shriner D., Veldre G., Viigimaa M., Kinra S., Prabhakaran D., Tripathy V., Langefeld C. D., Rosengren A., Thelle D. S., Corsi A. M., Singleton A., Hilton G., Salako T., Iwai N., Kita Y., Ogihara T., Ohkubo T., Okamura T., Ueshima H., Umemura S., Eyheramendy S., Meitinger T., Cho Y. S., Kim H. L., Scott J., Sehmi J. S., Hedblad B., Nilsson P., Smith G. D., Raffel L. J., Yao J., Schwartz S. M., Ikram M., W L., Mosley T. H., Seshadri S., Shrine N. R., Wain L. V., Zitting P., Cooper J. A., van Gilst W. H., Janipalli C. S., Mani K., Yajnik C. S., Mattace-Raso F. U., Lakatta E. G., Orru M., Scuteri A., Ala-Korpela M., Kangas A. J., Soininen P., Tukiainen T., Wurtz P., Ong R. T., Dorr M., Galan P., Hercberg S., Lathrop M., Zelenika D., Zhai G., Meschia J. F., Sharma P., Terzic J., Kumar M., Denniff M., Zukowska-Szczechowska E., Wagenknecht L. E., Fowkes F., Charchar F. J., Guo X., Rotimi C., Bots M. L., Brand E., Talmud P. J., Nyberg F., Laan M., Palmer L. J., van der Schouw Y. T., Casas J. P., Vineis P., Ganesh S. K., Wong T. Y., Tai E. S., Morris R. W., Marmot M. G., Miki T., Chandak G. R., Zhu X., Elosua R., Soranzo N., Sijbrands E. J., Uda M., Vasan R. S., Alizadeh B. Z., de Boer R. A., Boezen H. M., Hillege H. L., van der Klauw M. M., Ormel J., Rosmalen J. G., Slaets J. P., Lagou V., Welch R. P., Wheeler E., Rehnberg E., Rasmussen-Torvik L. J., Lecoeur C., Johnson P. C., Sennblad B., Salo P., Timpson N. J., Evans D. M., St Pourcain B., Bielak L. F., Horikoshi M., Navarro P., Raychaudhuri S., Chen H., Rybin D., Willems S. M., Song K., An P., Marullo L., Jansen H., Pankow J. S., Edkins S., Varga T. V., Oksa H., Antonella M., Kong A., Herder C., Antti J., Small K., Miljkovic I., Atalay M., Kiess W., Smit J. H., Campbell S., Fowkes G. R., Rathmann W., Maerz W., Watanabe R. M., de Geus E. J., Penninx B. W., Toenjes A., Peyser P. A., Korner A., Dupuis J., Cucca F., Balkau B., Bouatia-Naji N., Purcell S., Musunuru K., Ardissino D., Mannucci P. M., Anand S., Engert J. C., Morgan T., Spertus J. A., Stoll M., Girelli D., McKeown P. P., Patterson C. C., Merlini P. A., Berzuini C., Bernardinelli L., Peyvandi F., Tubaro M., Celli P., Fetiveau R., Marziliano N., Casari G., Galli M., Ribichini F., Rossi M., Bernardi F., Zonzin P., Piazza A., Yee J., Friedlander Y., Marrugat J., Subirana I., Sala J., Ramos R., Williams G., Nathan D. M., Macrae C. A., Berglund G., Asselta R., Duga S., Spreafico M., Daly M. J., Nemesh J., Korn J. M., Surti A., Gianniny L., Parkin M., Burtt N., Gabriel S. B., Wright B. J., Ball S. G., Schunkert I., Linsel-Nitschke P., Lieb W., Fischer M., Grosshennig A., Preuss M., Scholz M., Chen Z., Wilensky R., Matthai W., Qasim A., Hakonarson H. H., Devaney J., Pichard A. D., Kent K. M., Satler L., Lindsay J. M., Waksman R., Knouff C. W., Scheffold T., Berger K., Huge A., Martinelli N., Olivieri O., Corrocher R., Xie C., Ahmadi K. R., Ainali C., Bataille V., Bell J. T., Buil A., Dermitzakis E. T., Dimas A. S., Durbin R., Glass D., Hassanali N., Ingle C., Knowles D., Krestyaninova M., Lowe C. E., Meduri E., Di Meglio P., Montgomery S. B., Nestle F. O., Nica A. C., Nisbet J., O'rahilly S., Parts L., Potter S., Sekowska M., Shin S. Y., Surdulescu G., Travers M. E., Tsaprouni L., Tsoka S., Wilk A., Yang T. P., Higashio J., Williams R., Nato A., Ambite J. L., Deelman E., Manolio T., Heiss G., Taylor K., Avery C., Graff M., Lin D., Quibrera M., Cochran B., Kao L., Umans J., Cole S., Maccluer J., Person S., Gross M., Fornage M., Durda P., Jenny N., Patsy B., Arnold A., Buzkova P., Haines J., Murdock D., Glenn K., Brown-Gentry K., Thornton-Wells T., Dumitrescu L., Bush W. S., Mitchell S. L., Goodloe R., Wilson S., Boston J., Malinowski J., Restrepo N., Oetjens M., Fowke J., Spencer K., Pendergrass S., Le Marchand L., Park L., Tiirikainen M., Kolonel L., Cheng I., Wang H., Shohet R., Stram D., Henderson B., Monroe K., Anderson G., Carlson C., Prentice R., Lacroix A., Wu C., Carty C., Rosse S., Young A., Kocarnik J., Lin Y., Jackson R., Duggan D., Kuller L., He C., Sulem P., Barbalic M., Broer L., Byrne E. M., Gudbjartsson D. F., McArdle P. F., Porcu E., van Wingerden S. W., Zhuang W. V., Lauc L. B., Broekmans F. J., Burri A., Chen C., Corre T., Coviello A. D., D'adamo P., Davies G., Deary I. J., Ebrahim S., Fauser B. C., Ferreli L., Folsom A. R., Hankinson S. E., Hass M., Janssens A. C., Karasik D., Keyzer J., Kiel D. P., Lahti J., Lai S., Laisk T., Laven J. S., Liu J., Lopez L. M., Louwers Y. V., Marongiu M., Klaric I. M., Masciullo C., Melzer D., Newman A. B., Pare G., Peeters P. H., Pop V. J., Raikkonen K., Salumets A., Stacey S. N., Starr J. M., Stathopoulou M. G., Styrkarsdottir U., Tenesa A., Tryggvadottir L., Tsui K., van Dam R. M., van Gils C. H., van Nierop P., Vink J. M., Voorhuis M., Widen E., Wijnands-Van Gent C. J., Yerges-Armstrong L. M., Zgaga L., Zygmunt M., Buring J. E., Crisponi L., Demerath E. W., Streeten E. A., Murray A., Visser J. A., Lunetta K. L., Elks C. E., Cousminer D. L., Koller D. L., Lin P., Smith E. N., Warrington N. M., Alavere H., Berenson G. S., Blackburn H., Busonero F., Chen W., Couper D., Easton D. F., Eriksson J., Foroud T., Kilpelainen T. O., Li S., Murray S. S., Ness A. R., Northstone K., Peacock M., Pennell C. E., Pharoah P., Rafnar T., Rice J. P., Ring S. M., Schork N. J., Segre A. V., Sovio U., Srinivasan S. R., Tammesoo M. L., van Meurs J. B., Young L., Bierut L. J., and Econs M. J.
- Abstract
Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P < 5 × 10-8), 56 of which are novel. Five loci demonstrate clear evidence of several independent association signals, and many loci have significant effects on other metabolic phenotypes. The 97 loci account for ∼2.7% of BMI variation, and genome-wide estimates suggest that common variation accounts for >20 % of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis.
- Published
- 2015
14. Predictors of blood pressure response in the SYMPLICITY HTN-3 trial
- Author
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Kandzari, D. E., primary, Bhatt, D. L., additional, Brar, S., additional, Devireddy, C. M., additional, Esler, M., additional, Fahy, M., additional, Flack, J. M., additional, Katzen, B. T., additional, Lea, J., additional, Lee, D. P., additional, Leon, M. B., additional, Ma, A., additional, Massaro, J., additional, Mauri, L., additional, Oparil, S., additional, O'Neill, W. W., additional, Patel, M. R., additional, Rocha-Singh, K., additional, Sobotka, P. A., additional, Svetkey, L., additional, Townsend, R. R., additional, and Bakris, G. L., additional
- Published
- 2014
- Full Text
- View/download PDF
15. Identification of FUSE-binding protein 1 as a regulatory mRNA-binding protein that represses nucleophosmin translation
- Author
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Olanich, M E, primary, Moss, B L, additional, Piwnica-Worms, D, additional, Townsend, R R, additional, and Weber, J D, additional
- Published
- 2010
- Full Text
- View/download PDF
16. Renal impairment, hypertension and plasma urotensin II
- Author
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Mosenkis, A., primary, Kallem, R. R., additional, Danoff, T. M., additional, Aiyar, N., additional, Bazeley, J., additional, and Townsend, R. R., additional
- Published
- 2010
- Full Text
- View/download PDF
17. PS1-06: Increased Incident Renal Disease with ACE-1 + Thiazide Therapy for Hypertension: The Geisinger Clinic Population
- Author
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Langer, R. D, primary, Graham, J., additional, Hennessy, S., additional, Townsend, R. R, additional, Weber, V., additional, and Bloom, F., additional
- Published
- 2010
- Full Text
- View/download PDF
18. C-D2-01: Outcomes Associated With Thiazide Combinations for Second-line Treatment of Hypertension in Older Patients
- Author
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Langer, R. D, primary, Graham, J., additional, Hennessy, S., additional, Townsend, R. R, additional, Bloom, F., additional, and Weber, V., additional
- Published
- 2010
- Full Text
- View/download PDF
19. Aortic Pulse Pressure Is Associated With Carotid IMT in Chronic Kidney Disease: Report From Chronic Renal Insufficiency Cohort
- Author
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DeLoach, S. S., primary, Appel, L. J., additional, Chen, J., additional, Joffe, M. M., additional, Gadegbeku, C. A., additional, Mohler, E. R., additional, Parsa, A., additional, Perumal, K., additional, Rafey, M. A., additional, Steigerwalt, S. P., additional, Teal, V., additional, Townsend, R. R., additional, and Rosas, S. E., additional
- Published
- 2009
- Full Text
- View/download PDF
20. Airway proteins involved in bacterial clearance susceptible to cathepsin G proteolysis
- Author
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Farberman, M. M., primary, Akers, K. T., additional, Malone, J. P., additional, Erdman-Gilmore, P., additional, Townsend, R. R., additional, and Ferkol, T., additional
- Published
- 2009
- Full Text
- View/download PDF
21. What is the proper workup of a patient with hypertension?
- Author
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KATAKAM, R., primary, BRUKAMP, K., additional, and TOWNSEND, R. R., additional
- Published
- 2008
- Full Text
- View/download PDF
22. Change in the pattern of adrenal venous sampling over time in patients with primary aldosteronism
- Author
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Murashima, M, primary, Trerotola, S O, additional, Fraker, D L, additional, Han, D, additional, Townsend, R R, additional, and Cohen, D L, additional
- Published
- 2008
- Full Text
- View/download PDF
23. Human Urotensin II in the plasma of anephric subjects
- Author
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Mosenkis, A., primary, Danoff, T. M., additional, Aiyar, N., additional, Bazeley, J., additional, and Townsend, R. R., additional
- Published
- 2007
- Full Text
- View/download PDF
24. Lack of Symptoms in Patients with Histologic Evidence of Pheochromocytoma: A Diagnostic Challenge
- Author
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COHEN, D. L, primary, FRAKER, D., additional, and TOWNSEND, R. R, additional
- Published
- 2006
- Full Text
- View/download PDF
25. PROTEOMIC ANALYSIS OF PLASMA OVER TIME IN A MURINE MODEL OF INTRAABDOMINAL SEPSIS.
- Author
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McDunn, J. E., primary, Townsend, R. R., additional, and Cobb, J. P., additional
- Published
- 2004
- Full Text
- View/download PDF
26. Pheochromocytoma: The Expanding Genetic Differential Diagnosis
- Author
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Bryant, J., primary, Farmer, J., additional, Kessler, L. J., additional, Townsend, R. R., additional, and Nathanson, K. L., additional
- Published
- 2003
- Full Text
- View/download PDF
27. Breath-hold ultrafast three-dimensional gadolinium-enhanced MR angiography of the renovascular system.
- Author
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Siegelman, E S, primary, Gilfeather, M, additional, Holland, G A, additional, Carpenter, J P, additional, Golden, M A, additional, Townsend, R R, additional, and Schnall, M D, additional
- Published
- 1997
- Full Text
- View/download PDF
28. Ambulatory blood pressure monitoring
- Author
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Townsend, R R, primary and Ford, V, additional
- Published
- 1996
- Full Text
- View/download PDF
29. HCO3(-)-dependent conformational change in gastric parietal cell AE2, a glycoprotein naturally lacking sialic acid
- Author
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Zolotarev, A. S., primary, Townsend, R. R., additional, Stuart-Tilley, A., additional, and Alper, S. L., additional
- Published
- 1996
- Full Text
- View/download PDF
30. Potential role of molecular mimicry between Helicobacter pylori lipopolysaccharide and host Lewis blood group antigens in autoimmunity
- Author
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Appelmelk, B J, primary, Simoons-Smit, I, additional, Negrini, R, additional, Moran, A P, additional, Aspinall, G O, additional, Forte, J G, additional, De Vries, T, additional, Quan, H, additional, Verboom, T, additional, Maaskant, J J, additional, Ghiara, P, additional, Kuipers, E J, additional, Bloemena, E, additional, Tadema, T M, additional, Townsend, R R, additional, Tyagarajan, K, additional, Crothers, J M, additional, Monteiro, M A, additional, Savio, A, additional, and De Graaff, J, additional
- Published
- 1996
- Full Text
- View/download PDF
31. Ejaculatory duct obstruction: diagnosis and treatment with transrectal sonography.
- Author
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Meacham, R B, primary, Townsend, R R, additional, and Drose, J A, additional
- Published
- 1995
- Full Text
- View/download PDF
32. Seminal vesicle cysts associated with autosomal dominant polycystic kidney disease detected by sonography.
- Author
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Weingardt, J P, primary, Townsend, R R, additional, Russ, P D, additional, Rogers, P T, additional, and Fitzgerald, S W, additional
- Published
- 1995
- Full Text
- View/download PDF
33. Color Doppler evaluation of urethral diverticulum.
- Author
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Townsend, R R, primary, Meacham, R B, additional, and Drose, J A, additional
- Published
- 1994
- Full Text
- View/download PDF
34. Changes in lipolytic sensitivity following repeated epinephrine infusion in humans
- Author
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Townsend, R. R., primary, Klein, S., additional, and Wolfe, R. R., additional
- Published
- 1994
- Full Text
- View/download PDF
35. Pressor doses of angiotensin II increase insulin-mediated glucose uptake in normotensive men
- Author
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Townsend, R. R., primary and DiPette, D. J., additional
- Published
- 1993
- Full Text
- View/download PDF
36. Insulin enhances pressor responses to norepinephrine in rat mesenteric vasculature.
- Author
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Townsend, R. R., primary, Yamamoto, R., additional, Nickols, M., additional, DiPette, D. J., additional, and Nickols, G. A., additional
- Published
- 1992
- Full Text
- View/download PDF
37. CT of AIDS-related lymphoma.
- Author
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Townsend, R R, primary
- Published
- 1991
- Full Text
- View/download PDF
38. Combination of converting enzyme inhibitor with diuretic for the treatment of hypertension
- Author
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Townsend, R. R., primary
- Published
- 1990
- Full Text
- View/download PDF
39. Combined Doppler and morphologic sonographic evaluation of renal transplant rejection.
- Author
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Townsend, R R, primary, Tomlanovich, S J, additional, Goldstein, R B, additional, and Filly, R A, additional
- Published
- 1990
- Full Text
- View/download PDF
40. Sonographic diagnosis of perforation in patients with acute appendicitis.
- Author
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Borushok, K F, primary, Jeffrey, R B, additional, Laing, F C, additional, and Townsend, R R, additional
- Published
- 1990
- Full Text
- View/download PDF
41. Stimulation of fibrinogen biosynthesis by fibrinogen fragments D and E.
- Author
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Bell, William R., Kessler, Craig M., and Townsend, R. R.
- Published
- 1983
- Full Text
- View/download PDF
42. Separation of positional isomers of oligosaccharides and glycopeptides by high-performance anion-exchange chromatography with pulsed amperometric detection.
- Author
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Hardy, M R and Townsend, R R
- Abstract
High-performance anion-exchange (HPAE) chromatography under alkaline conditions (pH congruent to 13) has been found to efficiently separate neutral oligosaccharides (triose to undecaose) according to molecular size, sugar composition, and linkage of monosaccharide units. The method was able to resolve 1----3, 1----4, and 1----6 positional isomers of neutral oligosaccharides, which are defined as having the same number, type, sequence, and anomeric configurations of monosaccharides but differing in the linkage position of a single sugar. From correlating structural features of different oligosaccharides and retention times, we deduced that at least two factors are operative to determine the superior resolution of oligosaccharides by this type of chromatography: (i) the relative acidities of the hydroxyl groups and (ii) the accessibility of oxyanions of the oligosaccharides to the functional groups of the stationary phase. Splitting of peaks attributable to mutarotation was not observed. Reducing oligosaccharides were much more retained than their reduced counterparts. Linkage of Fuc(alpha 1-3) to GlcNAc of oligosaccharides markedly decreased retention times. Positional isomers of two branched monosaccharides, which differed by 1----6 and 1----4 linkages, were widely separated. The separation of 1----3 and 1----4 positional isomers of both tetrasaccharides and glycopeptides containing undecasaccharides demonstrated the significant improvement in resolution of HPAE compared to previous chromatographic methods by either reverse-phase or amine-bonded stationary phases. Picomole quantities of underivatized oligosaccharides have been detected by triple-pulse amperometric detection, which produced similar responses for a wide range of structures. Quantification of two triantennary glycopeptides from bovine fetuin by using either detector response or 1H NMR was comparable. The N-glycanase-catalyzed release of two 1----4 and 1----3 positional isomers of an undecasaccharide from a tryptic glycopeptide of bovine fetuin could be observed and quantified by direct injection of the enzyme mixture into the chromatograph.
- Published
- 1988
- Full Text
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43. Binding and endocytosis of glycoproteins and neoglycoproteins by isolated rabbit hepatocytes
- Author
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Connolly, D T, Townsend, R R, Kawaguchi, K, Hobish, M K, Bell, W R, and Lee, Y C
- Abstract
Rabbit hepatocytes were isolated by a collagenase perfusion technique, and used to study the binding and endocytosis of the glycoprotein, asialo-orosomucoid, and the neoglycoprotein, Gal39-bovine serum albumin. Both of these proteins contain exposed galactosyl residues, and were avidly bound by the lectin on the hepatic parenchymal cell surface. Steady state and kinetic experiments performed at 2 degrees C and at 37 degrees C revealed the presence of two apparent classes of binding sites totalling 4.7 X 10(5) sites/cell at 2 degrees C, and 6.3 X 10(5) sites/cell at 37 degrees C. At 37 degrees C, both classes of sites participated in internalization of bound ligand. The cells were capable of internalizing about 60 000 molecules/min per cell. The process appeared to be first-order, with a rate constant k = 0.098 min-1 and t1/2 = 7.1 +/- 0.6 min. Binding could be inhibited by galactose-containing compounds, EGTA, and by anti-(hepatic lectin) immunoglobulin G. The inhibition by antibody appeared to be reversible upon removal of antibody-containing medium.
- Published
- 1983
- Full Text
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44. The Major Subunit of the Rat Asialoglycoprotein Receptor Can Function Alone as a Receptor
- Author
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Braiterman, L T, Chance, S C, Porter, W R, Lee, Y C, Townsend, R R, and Hubbard, A L
- Abstract
Mammalian hepatic asialoglycoprotein receptors (ASGP-R) are composed of two unique, but closely related polypeptides, which in the rat are designated rat hepatic lectins 1 and 2/3 (RHL 1, RHL 2/3). Despite numerous studies, the composition of a functional ASGP-R has remained unclear. We examined this question in rat hepatoma tissue culture (HTC) cells (which lack endogenous ASGP-R) that were co-transfected with cDNAs for both RHL 1 and RHL 2/3. The original population was cloned, but derivatives were unstable. We therefore used fluorescence-activated cell sorting to separate a subpopulation of cells (positive) that specifically endocytosed fluoresceinated asialoorosomucoid (ASOR) from one that did not (negative). We then used indirect immunofluorescence with polypeptide-specific ASGP-R antibodies, immunoanalysis, and binding and uptake studies with two Gal ligands (ASOR andNAc-galactosylated poly-L-lysine (Gal-Lys] to further define the ASGP-R status in these two populations. As reported by others, we found that expression of both RHL 1 and RHL 2/3 in the positive cells resulted in binding, uptake and degradation of ASOR, the most commonly used ASGP-R ligand. The negative cells expressed only RHL 1 and neither bound nor processed ASOR. However, the presence of RHL 1 was sufficient for specific high affinity binding and processing of the synthetic ligand, Gal-Lys, by negative cells. These results show that RHL 1 can function as an ASGP-R, given a highly galactosylated ligand, and that RHL 2/3 must play an important role in the organization of native ASGP-R in the membrane.
- Published
- 1989
- Full Text
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45. Carbohydrate structure of human fibrinogen. Use of 300-MHz 1H-NMR to characterize glycosidase-treated glycopeptides.
- Author
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Townsend, R R, Hilliker, E, Li, Y T, Laine, R A, Bell, W R, and Lee, Y C
- Abstract
The carbohydrate composition of fibrinogen and constituent S-carboxymethylated chains was determined. All the carbohydrate on the parent molecule could be accounted for on the B beta and gamma chains. The A alpha chain was found to be devoid of carbohydrate. Glycopeptides were prepared from fibrinogen, B beta, and gamma chains by pronase digestion and subsequent chromatography on Sephadex G-50. The 300-MHz 1H-NMR spectra of glycopeptides from all three sources were consistent with biantennary type oligosaccharide chains. The glycopeptides resulting from exoglycosidase digestions were examined with 300-MHz 1H-NMR spectroscopy, and the changes in the signals caused by selective removal of sugar residues were studied. This technique enabled us to assign each anomeric proton to the corresponding monosaccharide unit independent of previous work. Our results indicate that fibrinogen glycopeptides are of the biantennary type, and are in complete agreement with the previously reported peak assignments (Vliegenthart, J. F. G., van Halbeek, H., and Dorland, L. (1981) Pure Appl. Chemn. 53, 45-77). Affinity chromatography of the glycopeptides on concanavalin A-Sepharose also showed that the glycopeptides from fibrinogen are greater than 95% biantennary oligosaccharide chains. Based on carbohydrate composition, 1H-NMR spectroscopy, sequential exoglycosidase digestion, and gas chromatography-mass spectrometry of derived partially methylated alditol acetates, we propose that fibrinogen contains four oligosaccharide chains of the structure shown below. (formula, see text)
- Published
- 1982
- Full Text
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46. Binding of synthetic oligosaccharides to the hepatic Gal/GalNAc lectin. Dependence on fine structural features.
- Author
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Lee, Y C, Townsend, R R, Hardy, M R, Lönngren, J, Arnarp, J, Haraldsson, M, and Lönn, H
- Abstract
A series of synthetic oligosaccharides, resembling natural N-acetyllactosamine type glycans, were tested for their ability to inhibit the binding of labeled ligand to the mammalian hepatic lectin on rabbit hepatocytes at 2 degrees C. A dramatic hierarchy of inhibitory potency (tetraantennary greater than triantennary much greater than biantennary much greater than monoantennary) could be demonstrated. The range of concentration required for 50% inhibition of labeled ligand binding extended from approximately 1 mM, for the monoantennary oligosaccharides, to approximately 1 nM for triantennary oligosaccharides, even though the absolute Gal concentration increased only 3-fold. It was found that the number of Gal residues/cluster and their branching mode are major determinants of binding affinity of ligands to the hepatic lectin on the surface of hepatocytes.
- Published
- 1983
- Full Text
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47. Rapid release of galactose-terminated ligands after endocytosis by hepatic parenchymal cells: evidence for a role of carbohydrate structure in the release of internalized ligand from receptor.
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Townsend, R R, Wall, D A, Hubbard, A L, and Lee, Y C
- Abstract
We have compared the behavior of 125I-labeled asialoorosomucoid (ASOR) and 125I-labeled asialotriantennary glycopeptide (TRI) from alpha-1-protease inhibitor in the perfused rat liver. These two ligands are recognized and internalized by the Gal/GalNAc receptor system of hepatocytes. We found that both ligands could be efficiently degraded when continuously perfused through a liver at 37 degrees C. However, as much as 51% of the internalized 125I-labeled TRI was rapidly (t1/2 = 3 min) released intact into the perfusion medium under conditions that permitted ligand-receptor association. In contrast, ASOR was totally degraded under these conditions. When dissociation was promoted (i.e., in the presence of GalNAc or EGTA), as much as 57% of the internalized ASOR was rapidly released (also intact). In each case, the shorter the initial internalization phase, the greater the proportion of ligand that was subsequently released. Neither the degree of receptor occupancy nor the temperature (16-37 degrees C) during the initial internalization phase influenced the rate or extent of the release process. Electron microscopic localization of internal ASOR-horseradish peroxidase conjugate demonstrated that peripheral endosomes were the major compartment labeled during exocytosis. We conclude that substantial fractions of both ligands rapidly return to the cell surface after internalization, ASOR bound to receptor and most of TRI free from receptor. The remaining ligand molecules enter the lysosomal pathway.
- Published
- 1984
- Full Text
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48. Purification and structure-function analysis of native, PNGase F-treated, and endo-β-galactosidase-treated CHIP28 water channels
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Hoek, A. N., Wiener, M. C., Jean-Marc Verbavatz, Brown, D., Lipniunas, P. H., Townsend, R. R., and Verkman, A. S.
49. Residual Cx45 and its relationship to Cx43 in murine ventricular myocardium
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Bao, M., Kanter, E. M., Huang, R. Y. C., Stephan Maxeiner, Frank, M., Zhang, Y., Schuessler, R. B., Smith, T. W., Townsend, R. R., Rohrs, H. W., Berthoud, V. M., Willecke, K., Laing, J. G., and Yamada, K. A.
50. Safety of intravenous Gadolinium (Gd-BOPTA) infusion in patients with renal insufficiency
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Townsend, R. R., Cohen, D. L., Richard Katholi, Swan, S. K., Davies, B. E., Bensel, K., Lambrecht, L., and Parker, J.
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