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207 results on '"Townsend, Alain R"'

1. Proactive vaccination using multiviral Quartet Nanocages to elicit broad anti-coronavirus responses

Author

Hills, Rory A., Tan, Tiong Kit, Cohen, Alexander A., Keeffe, Jennifer R., Keeble, Anthony H., Gnanapragasam, Priyanthi N. P., Storm, Kaya N., Rorick, Annie V., West, Jr., Anthony P., Hill, Michelle L., Liu, Sai, Gilbert-Jaramillo, Javier, Afzal, Madeeha, Napier, Amy, Admans, Gabrielle, James, William S., Bjorkman, Pamela J., Townsend, Alain R., and Howarth, Mark R.

Published
2024
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2. Publisher Correction: Semaphorin 3A causes immune suppression by inducing cytoskeletal paralysis in tumour-specific CD8+ T cells

Author

Barnkob, Mike B., Michaels, Yale S., André, Violaine, Macklin, Philip S., Gileadi, Uzi, Valvo, Salvatore, Rei, Margarida, Kulicke, Corinna, Chen, Ji-Li, Jain, Vitul, Woodcock, Victoria K., Colin-York, Huw, Hadjinicolaou, Andreas V., Kong, Youxin, Mayya, Viveka, Mazet, Julie M., Mead, Gracie-Jennah, Bull, Joshua A., Rijal, Pramila, Pugh, Christopher W., Townsend, Alain R., Gérard, Audrey, Olsen, Lars R., Fritzsche, Marco, Fulga, Tudor A., Dustin, Michael L., Jones, E. Yvonne, and Cerundolo, Vincenzo

Published
2024
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3. Semaphorin 3A causes immune suppression by inducing cytoskeletal paralysis in tumour-specific CD8+ T cells

Author

Barnkob, Mike B., Michaels, Yale S., André, Violaine, Macklin, Philip S., Gileadi, Uzi, Valvo, Salvatore, Rei, Margarida, Kulicke, Corinna, Chen, Ji-Li, Jain, Vitul, Woodcock, Victoria K., Colin-York, Huw, Hadjinicolaou, Andreas V., Kong, Youxin, Mayya, Viveka, Mazet, Julie M., Mead, Gracie-Jennah, Bull, Joshua A., Rijal, Pramila, Pugh, Christopher W., Townsend, Alain R., Gérard, Audrey, Olsen, Lars R., Fritzsche, Marco, Fulga, Tudor A., Dustin, Michael L., Jones, E. Yvonne, and Cerundolo, Vincenzo

Published
2024
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6. The presence of broadly neutralizing anti-SARS-CoV-2 RBD antibodies elicited by primary series and booster dose of COVID-19 vaccine

Author

Chen, Xiaorui, primary, Mohapatra, Arpita, additional, Nguyen, Hong Thuy Vy, additional, Schimanski, Lisa, additional, Kit Tan, Tiong, additional, Rijal, Pramila, additional, Chen, Cheng-Pin, additional, Cheng, Shu-Hsing, additional, Lee, Wen-Hsin, additional, Chou, Yu-Chi, additional, Townsend, Alain R., additional, Ma, Che, additional, and Huang, Kuan-Ying A., additional

Published
2024
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7. Semmaphorin 3 A causes immune suppression by inducing cytoskeletal paralysis in tumour-specific CD8+ T cells

Author

Barnkob, Mike B., primary, Michaels, Yale S., additional, André, Violaine, additional, Macklin, Philip S., additional, Gileadi, Uzi, additional, Valvo, Salvatore, additional, Rei, Margarida, additional, Kulicke, Corinna, additional, Chen, Ji-Li, additional, Jain, Vitul, additional, Woodcock, Victoria K., additional, Colin-York, Huw, additional, Hadjinicolaou, Andreas V., additional, Kong, Youxin, additional, Mayya, Viveka, additional, Mazet, Julie M., additional, Mead, Gracie-Jennah, additional, Bull, Joshua A., additional, Rijal, Pramila, additional, Pugh, Christopher W., additional, Townsend, Alain R., additional, Gérard, Audrey, additional, Olsen, Lars R., additional, Fritzsche, Marco, additional, Fulga, Tudor A., additional, Dustin, Michael L., additional, Jones, E. Yvonne, additional, and Cerundolo, Vincenzo, additional

Published
2024
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8. Semmaphorin 3 A causes immune suppression by inducing cytoskeletal paralysis in tumour-specific CD8+ T cells

Author

Barnkob, Mike B., Michaels, Yale S., André, Violaine, Macklin, Philip S., Gileadi, Uzi, Valvo, Salvatore, Rei, Margarida, Kulicke, Corinna, Chen, Ji Li, Jain, Vitul, Woodcock, Victoria K., Colin-York, Huw, Hadjinicolaou, Andreas V., Kong, Youxin, Mayya, Viveka, Mazet, Julie M., Mead, Gracie Jennah, Bull, Joshua A., Rijal, Pramila, Pugh, Christopher W., Townsend, Alain R., Gérard, Audrey, Olsen, Lars R., Fritzsche, Marco, Fulga, Tudor A., Dustin, Michael L., Jones, E. Yvonne, Cerundolo, Vincenzo, Barnkob, Mike B., Michaels, Yale S., André, Violaine, Macklin, Philip S., Gileadi, Uzi, Valvo, Salvatore, Rei, Margarida, Kulicke, Corinna, Chen, Ji Li, Jain, Vitul, Woodcock, Victoria K., Colin-York, Huw, Hadjinicolaou, Andreas V., Kong, Youxin, Mayya, Viveka, Mazet, Julie M., Mead, Gracie Jennah, Bull, Joshua A., Rijal, Pramila, Pugh, Christopher W., Townsend, Alain R., Gérard, Audrey, Olsen, Lars R., Fritzsche, Marco, Fulga, Tudor A., Dustin, Michael L., Jones, E. Yvonne, and Cerundolo, Vincenzo

Abstract

Semaphorin-3A (SEMA3A) functions as a chemorepulsive signal during development and can affect T cells by altering their filamentous actin (F-actin) cytoskeleton. The exact extent of these effects on tumour-specific T cells are not completely understood. Here we demonstrate that Neuropilin-1 (NRP1) and Plexin-A1 and Plexin-A4 are upregulated on stimulated CD8+ T cells, allowing tumour-derived SEMA3A to inhibit T cell migration and assembly of the immunological synapse. Deletion of NRP1 in both CD4+ and CD8+ T cells enhance CD8+ T-cell infiltration into tumours and restricted tumour growth in animal models. Conversely, over-expression of SEMA3A inhibit CD8+ T-cell infiltration. We further show that SEMA3A affects CD8+ T cell F-actin, leading to inhibition of immune synapse formation and motility. Examining a clear cell renal cell carcinoma patient cohort, we find that SEMA3A expression is associated with reduced survival, and that T-cells appear trapped in SEMA3A rich regions. Our study establishes SEMA3A as an inhibitor of effector CD8+ T cell tumour infiltration, suggesting that blocking NRP1 could improve T cell function in tumours.

Published
2024

9. A COVID-19 vaccine candidate using SpyCatcher multimerization of the SARS-CoV-2 spike protein receptor-binding domain induces potent neutralising antibody responses

Author

Tan, Tiong Kit, Rijal, Pramila, Rahikainen, Rolle, Keeble, Anthony H., Schimanski, Lisa, Hussain, Saira, Harvey, Ruth, Hayes, Jack W. P., Edwards, Jane C., McLean, Rebecca K., Martini, Veronica, Pedrera, Miriam, Thakur, Nazia, Conceicao, Carina, Dietrich, Isabelle, Shelton, Holly, Ludi, Anna, Wilsden, Ginette, Browning, Clare, Zagrajek, Adrian K., Bialy, Dagmara, Bhat, Sushant, Stevenson-Leggett, Phoebe, Hollinghurst, Philippa, Tully, Matthew, Moffat, Katy, Chiu, Chris, Waters, Ryan, Gray, Ashley, Azhar, Mehreen, Mioulet, Valerie, Newman, Joseph, Asfor, Amin S., Burman, Alison, Crossley, Sylvia, Hammond, John A., Tchilian, Elma, Charleston, Bryan, Bailey, Dalan, Tuthill, Tobias J., Graham, Simon P., Duyvesteyn, Helen M. E., Malinauskas, Tomas, Huo, Jiandong, Tree, Julia A., Buttigieg, Karen R., Owens, Raymond J., Carroll, Miles W., Daniels, Rodney S., McCauley, John W., Stuart, David I., Huang, Kuan-Ying A., Howarth, Mark, and Townsend, Alain R.

Published
2021
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10. Structural basis for the neutralization of SARS-CoV-2 by an antibody from a convalescent patient

Author

Zhou, Daming, Duyvesteyn, Helen M. E., Chen, Cheng-Pin, Huang, Chung-Guei, Chen, Ting-Hua, Shih, Shin-Ru, Lin, Yi-Chun, Cheng, Chien-Yu, Cheng, Shu-Hsing, Huang, Yhu-Chering, Lin, Tzou-Yien, Ma, Che, Huo, Jiandong, Carrique, Loic, Malinauskas, Tomas, Ruza, Reinis R., Shah, Pranav N. M., Tan, Tiong Kit, Rijal, Pramila, Donat, Robert F., Godwin, Kerry, Buttigieg, Karen R., Tree, Julia A., Radecke, Julika, Paterson, Neil G., Supasa, Piyada, Mongkolsapaya, Juthathip, Screaton, Gavin R., Carroll, Miles W., Gilbert-Jaramillo, Javier, Knight, Michael L., James, William, Owens, Raymond J., Naismith, James H., Townsend, Alain R., Fry, Elizabeth E., Zhao, Yuguang, Ren, Jingshan, Stuart, David I., and Huang, Kuan-Ying A.

Published
2020
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11. Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2

Author

Huo, Jiandong, Le Bas, Audrey, Ruza, Reinis R., Duyvesteyn, Helen M. E., Mikolajek, Halina, Malinauskas, Tomas, Tan, Tiong Kit, Rijal, Pramila, Dumoux, Maud, Ward, Philip N., Ren, Jingshan, Zhou, Daming, Harrison, Peter J., Weckener, Miriam, Clare, Daniel K., Vogirala, Vinod K., Radecke, Julika, Moynié, Lucile, Zhao, Yuguang, Gilbert-Jaramillo, Javier, Knight, Michael L., Tree, Julia A., Buttigieg, Karen R., Coombes, Naomi, Elmore, Michael J., Carroll, Miles W., Carrique, Loic, Shah, Pranav N. M., James, William, Townsend, Alain R., Stuart, David I., Owens, Raymond J., and Naismith, James H.

Published
2020
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14. Structure–function analysis of neutralizing antibodies to H7N9 influenza from naturally infected humans

Author

Huang, Kuan-Ying A., Rijal, Pramila, Jiang, Haihai, Wang, Beibei, Schimanski, Lisa, Dong, Tao, Liu, Yo-Min, Chang, Pengxiang, Iqbal, Munir, Wang, Mu-Chun, Chen, Zhihai, Song, Rui, Huang, Chung-Chi, Yang, Jeng-How, Qi, Jianxun, Lin, Tzou-Yien, Li, Ang, Powell, Timothy J., Jan, Jia-Tsrong, Ma, Che, Gao, George F., Shi, Yi, and Townsend, Alain R.

Published
2019
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15. Multiviral Quartet Nanocages Elicit Broad Anti-Coronavirus Responses for Proactive Vaccinology

Author

Hills, Rory A., Tan, Tiong Kit, Cohen, Alexander A., Keeffe, Jennifer R., Keeble, Anthony H., Gnanapragasam, Priyanthi N. P., Storm, Kaya N., Hill, Michelle L., Liu, Sai, Gilbert-Jaramillo, Javier, Afzal, Madeeha, Napier, Amy, James, William S., Bjorkman, Pamela J., Townsend, Alain R., Howarth, Mark, Hills, Rory A., Tan, Tiong Kit, Cohen, Alexander A., Keeffe, Jennifer R., Keeble, Anthony H., Gnanapragasam, Priyanthi N. P., Storm, Kaya N., Hill, Michelle L., Liu, Sai, Gilbert-Jaramillo, Javier, Afzal, Madeeha, Napier, Amy, James, William S., Bjorkman, Pamela J., Townsend, Alain R., and Howarth, Mark

Abstract

Defending against future pandemics may require vaccine platforms that protect across a range of related pathogens. The presentation of multiple receptor-binding domains (RBDs) from evolutionarily-related viruses on a nanoparticle scaffold elicits a strong antibody response to conserved regions. Here we produce quartets of tandemly-linked RBDs from SARS-like betacoronaviruses coupled to the mi3 nanocage through a SpyTag/SpyCatcher spontaneous reaction. These Quartet Nanocages induce a high level of neutralizing antibodies against several different coronaviruses, including against viruses not represented on the vaccine. In animals primed with SARS-CoV-2 Spike, boost immunizations with Quartet Nanocages increased the strength and breadth of an otherwise narrow immune response. Quartet Nanocages are a strategy with potential to confer heterotypic protection against emergent zoonotic coronavirus pathogens and facilitate proactive pandemic protection.

Published
2023

16. Author Correction: Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2

Author

Huo, Jiandong, Bas, Audrey Le, Ruza, Reinis R., Duyvesteyn, Helen M. E., Mikolajek, Halina, Malinauskas, Tomas, Tan, Tiong Kit, Rijal, Pramila, Dumoux, Maud, Ward, Philip N., Ren, Jingshan, Zhou, Daming, Harrison, Peter J., Weckener, Miriam, Clare, Daniel K., Vogirala, Vinod K., Radecke, Julika, Moynié, Lucile, Zhao, Yuguang, Gilbert-Jaramillo, Javier, Knight, Michael L., Tree, Julia A., Buttigieg, Karen R., Coombes, Naomi, Elmore, Michael J., Carroll, Miles W., Carrique, Loic, Shah, Pranav N. M., James, William, Townsend, Alain R., Stuart, David I., Owens, Raymond J., and Naismith, James H.

Published
2021
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17. Multiviral Quartet Nanocages Elicit Broad Anti-Coronavirus Responses for Proactive Vaccinology

Author

Hills, Rory A., primary, Tan, Tiong Kit, additional, Cohen, Alexander A., additional, Keeffe, Jennifer R., additional, Keeble, Anthony H., additional, Gnanapragasam, Priyanthi N.P., additional, Storm, Kaya N., additional, Hill, Michelle L., additional, Liu, Sai, additional, Gilbert-Jaramillo, Javier, additional, Afzal, Madeeha, additional, Napier, Amy, additional, James, William S., additional, Bjorkman, Pamela J., additional, Townsend, Alain R., additional, and Howarth, Mark, additional

Published
2023
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19. Author Correction: Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2

Author

Huo, Jiangdong, Le Bas, Audrey, Ruza, Reinis R., Duyvesteyn, Helen M. E., Mikolajek, Halina, Malinauskas, Tomas, Tan, Tiong Kit, Rijal, Pramila, Dumoux, Maud, Ward, Philip N., Ren, Jingshan, Zhou, Daming, Harrison, Peter J., Weckener, Miriam, Clare, Daniel K., Vogirala, Vinod K., Radecke, Julika, Moynié, Lucile, Zhao, Yuguang, Gilbert-Jaramillo, Javier, Knight, Michael L., Tree, Julia A., Buttigieg, Karen R., Coombes, Naomi, Elmore, Michael J., Carroll, Miles W., Carrique, Loic, Shah, Pranav N. M., James, William, Townsend, Alain R., Stuart, David I., Owens, Raymond J., and Naismith, James H.

Published
2020
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21. Mosaic RBD nanoparticles protect against challenge by diverse sarbecoviruses in animal models

Author

Cohen, Alexander A., primary, van Doremalen, Neeltje, additional, Greaney, Allison J., additional, Andersen, Hanne, additional, Sharma, Ankur, additional, Starr, Tyler N., additional, Keeffe, Jennifer R., additional, Fan, Chengcheng, additional, Schulz, Jonathan E., additional, Gnanapragasam, Priyanthi N. P., additional, Kakutani, Leesa M., additional, West, Anthony P., additional, Saturday, Greg, additional, Lee, Yu E., additional, Gao, Han, additional, Jette, Claudia A., additional, Lewis, Mark G., additional, Tan, Tiong K., additional, Townsend, Alain R., additional, Bloom, Jesse D., additional, Munster, Vincent J., additional, and Bjorkman, Pamela J., additional

Published
2022
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22. Mosaic RBD nanoparticles protect against multiple sarbecovirus challenges in animal models

Author

Cohen, Alexander A., van Doremalen, Neeltje, Greaney, Allison J., Andersen, Hanne, Sharma, Ankur, Starr, Tyler N., Keeffe, Jennifer R., Fan, Chengcheng, Schulz, Jonathan E., Gnanapragasam, Priyanthi N. P., Kakutani, Leesa M., West, Anthony P., Jr., Saturday, Greg, Lee, Yu E., Gao, Han, Jette, Claudia A., Lewis, Mark G., Tan, Tiong K., Townsend, Alain R., Bloom, Jesse D., Munster, Vincent J., Bjorkman, Pamela J., Cohen, Alexander A., van Doremalen, Neeltje, Greaney, Allison J., Andersen, Hanne, Sharma, Ankur, Starr, Tyler N., Keeffe, Jennifer R., Fan, Chengcheng, Schulz, Jonathan E., Gnanapragasam, Priyanthi N. P., Kakutani, Leesa M., West, Anthony P., Jr., Saturday, Greg, Lee, Yu E., Gao, Han, Jette, Claudia A., Lewis, Mark G., Tan, Tiong K., Townsend, Alain R., Bloom, Jesse D., Munster, Vincent J., and Bjorkman, Pamela J.

Abstract

To combat future SARS-CoV-2 variants and spillovers of SARS-like betacoronaviruses (sarbecoviruses) threatening global health, we designed mosaic nanoparticles presenting randomly-arranged sarbecovirus spike receptor-binding domains (RBDs) to elicit antibodies against conserved/relatively-occluded, rather than variable/immunodominant/exposed, epitopes. We compared immune responses elicited by mosaic-8 (SARS-CoV-2 and seven animal sarbecoviruses) and homotypic (only SARS-CoV-2) RBD-nanoparticles in mice and macaques, observing stronger responses elicited by mosaic-8 to mismatched (not on nanoparticles) strains including SARS-CoV and animal sarbecoviruses. Mosaic-8 immunization showed equivalent neutralization of SARS-CoV-2 variants including Omicron and protected from SARS-CoV-2 and SARS-CoV challenges, whereas homotypic SARS-CoV-2 immunization protected only from SARS-CoV-2 challenge. Epitope mapping demonstrated increased targeting of conserved epitopes after mosaic-8 immunization. Together, these results suggest mosaic-8 RBD-nanoparticles could protect against SARS-CoV-2 variants and future sarbecovirus spillovers.

Published
2022

23. Mosaic RBD nanoparticles protect against multiple sarbecovirus challenges in animal models

Author

Cohen, Alexander A., primary, van Doremalen, Neeltje, additional, Greaney, Allison J., additional, Andersen, Hanne, additional, Sharma, Ankur, additional, Starr, Tyler N., additional, Keeffe, Jennifer R., additional, Fan, Chengcheng, additional, Schulz, Jonathan E., additional, Gnanapragasam, Priyanthi N.P., additional, Kakutani, Leesa M., additional, West, Anthony P, additional, Saturday, Greg, additional, Lee, Yu E., additional, Gao, Han, additional, Jette, Claudia A., additional, Lewis, Mark G., additional, Tan, Tiong K., additional, Townsend, Alain R., additional, Bloom, Jesse D., additional, Munster, Vincent J., additional, and Bjorkman, Pamela J., additional

Published
2022
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24. Lung-targeting lentiviral vector for passive immunisation against influenza

Author

Tan, Tiong Kit, Gamlen, Toby P E, Rijal, Pramila, Townsend, Alain R, Gill, Deborah R, and Hyde, Stephen C

Subjects
Pulmonary and Respiratory Medicine, viruses, Transgene, Genetic Vectors, Gene Expression, Hemagglutinin Glycoproteins, Influenza Virus, Brief Communication, medicine.disease_cause, Sendai virus, law.invention, Viral vector, Mice, 03 medical and health sciences, Influenza A Virus, H1N1 Subtype, 0302 clinical medicine, Orthomyxoviridae Infections, respiratory infection, law, Weight Loss, Animals, Medicine, Transgenes, 030212 general & internal medicine, Vector (molecular biology), Lung, chemistry.chemical_classification, biology, business.industry, Immunization, Passive, Respiratory infection, Simian immunodeficiency virus, biology.organism_classification, infection control, Antibodies, Neutralizing, Virology, 3. Good health, 030228 respiratory system, chemistry, Immunoglobulin G, Recombinant DNA, Simian Immunodeficiency Virus, viral infection, business, Glycoprotein
Abstract

When recombinant simian immunodeficiency virus (SIV) is pseudotyped with the F and HN glycoproteins from murine respiratory Sendai virus (rSIV.F/HN), it provides efficient lung cell targeting and lifelong transgene expression in the murine airways. We have shown that a single dose of rSIV.F/HN can direct stable expression of neutralising antibody against influenza in the murine airways and systemic circulation, and protects mice against two different influenza strains in lethal challenge experiments. These data suggest that rSIV.F/HN could be used as a vector for passive immunisation against influenza and other respiratory pathogens.

Published
2020

25. Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses

Author

Dejnirattisai, Wanwisa, Huo, Jiandong, Zhou, Daming, Zahradník, Jiří, Supasa, Piyada, Liu, Chang, Duyvesteyn, Helen M.E., Ginn, Helen M., Mentzer, Alexander J., Tuekprakhon, Aekkachai, Nutalai, Rungtiwa, Wang, Beibei, Dijokaite, Aiste, Khan, Suman, Avinoam, Ori, Bahar, Mohammad, Skelly, Donal, Adele, Sandra, Johnson, Sile Ann, Amini, Ali, Ritter, Thomas, Mason, Chris, Dold, Christina, Pan, Daniel, Assadi, Sara, Bellass, Adam, Omo-Dare, Nikki, Koeckerling, David, Flaxman, Amy, Jenkin, Daniel, Aley, Parvinder K, Voysey, Merryn, Clemens, Sue Ann Costa, Naveca, Felipe Gomes, Nascimento, Valdinete, Nascimento, Fernanda, Fernandes da Costa, Cristiano, Resende, Paola Cristina, Pauvolid-Correa, Alex, Siqueira, Marilda M., Baillie, Vicky, Serafin, Natali, Ditse, Zanele, Da Silva, Kelly, Madhi, Shabir, Nunes, Marta C, Malik, Tariq, Openshaw, Peter JM, Baillie, J Kenneth, Semple, Malcolm G, Townsend, Alain R, Huang, Kuan-Ying A., Tan, Tiong Kit, Carroll, Miles W., Klenerman, Paul, Barnes, Eleanor, Dunachie, Susanna J., Constantinides, Bede, Webster, Hermione, Crook, Derrick, Pollard, Andrew J, Lambe, Teresa, Paterson, Neil G., Williams, Mark A., Hall, David R., Fry, Elizabeth E., Mongkolsapaya, Juthathip, Ren, Jingshan, Schreiber, Gideon, Stuart, David I., and Screaton, Gavin R

Subjects
Article
Abstract

SummaryOn the 24th November 2021 the sequence of a new SARS CoV-2 viral isolate spreading rapidly in Southern Africa was announced, containing far more mutations in Spike (S) than previously reported variants. Neutralization titres of Omicron by sera from vaccinees and convalescent subjects infected with early pandemic as well as Alpha, Beta, Gamma, Delta are substantially reduced or fail to neutralize. Titres against Omicron are boosted by third vaccine doses and are high in cases both vaccinated and infected by Delta. Mutations in Omicron knock out or substantially reduce neutralization by most of a large panel of potent monoclonal antibodies and antibodies under commercial development. Omicron S has structural changes from earlier viruses, combining mutations conferring tight binding to ACE2 to unleash evolution driven by immune escape, leading to a large number of mutations in the ACE2 binding site which rebalance receptor affinity to that of early pandemic viruses.

Published
2021

26. SARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses

Author

Dejnirattisai, Wanwisa, primary, Huo, Jiandong, additional, Zhou, Daming, additional, Zahradník, Jiří, additional, Supasa, Piyada, additional, Liu, Chang, additional, Duyvesteyn, Helen M.E., additional, Ginn, Helen M., additional, Mentzer, Alexander J., additional, Tuekprakhon, Aekkachai, additional, Nutalai, Rungtiwa, additional, Wang, Beibei, additional, Dijokaite, Aiste, additional, Khan, Suman, additional, Avinoam, Ori, additional, Bahar, Mohammad, additional, Skelly, Donal, additional, Adele, Sandra, additional, Johnson, Sile Ann, additional, Amini, Ali, additional, Ritter, Thomas G., additional, Mason, Chris, additional, Dold, Christina, additional, Pan, Daniel, additional, Assadi, Sara, additional, Bellass, Adam, additional, Omo-Dare, Nicola, additional, Koeckerling, David, additional, Flaxman, Amy, additional, Jenkin, Daniel, additional, Aley, Parvinder K., additional, Voysey, Merryn, additional, Costa Clemens, Sue Ann, additional, Naveca, Felipe Gomes, additional, Nascimento, Valdinete, additional, Nascimento, Fernanda, additional, Fernandes da Costa, Cristiano, additional, Resende, Paola Cristina, additional, Pauvolid-Correa, Alex, additional, Siqueira, Marilda M., additional, Baillie, Vicky, additional, Serafin, Natali, additional, Kwatra, Gaurav, additional, Da Silva, Kelly, additional, Madhi, Shabir A., additional, Nunes, Marta C., additional, Malik, Tariq, additional, Openshaw, Peter J.M., additional, Baillie, J. Kenneth, additional, Semple, Malcolm G., additional, Townsend, Alain R., additional, Huang, Kuan-Ying A., additional, Tan, Tiong Kit, additional, Carroll, Miles W., additional, Klenerman, Paul, additional, Barnes, Eleanor, additional, Dunachie, Susanna J., additional, Constantinides, Bede, additional, Webster, Hermione, additional, Crook, Derrick, additional, Pollard, Andrew J., additional, Lambe, Teresa, additional, Paterson, Neil G., additional, Williams, Mark A., additional, Hall, David R., additional, Fry, Elizabeth E., additional, Mongkolsapaya, Juthathip, additional, Ren, Jingshan, additional, Schreiber, Gideon, additional, Stuart, David I., additional, Screaton, Gavin R., additional, Conlon, Christopher, additional, Deeks, Alexandra S., additional, Frater, John, additional, Frending, Lisa, additional, Gardiner, Siobhan, additional, Jämsén, Anni, additional, Jeffery, Katie, additional, Malone, Tom, additional, Phillips, Eloise, additional, Rothwell, Lucy, additional, Stafford, Lizzie, additional, Baillie, J Kenneth, additional, Openshaw, Peter JM., additional, Carson, Gail, additional, Alex, Beatrice, additional, Andrikopoulos, Petros, additional, Bach, Benjamin, additional, Barclay, Wendy S., additional, Bogaert, Debby, additional, Chand, Meera, additional, Chechi, Kanta, additional, Cooke, Graham S., additional, da Silva Filipe, Ana, additional, de Silva, Thushan, additional, Docherty, Annemarie B., additional, dos Santos Correia, Gonçalo, additional, Dumas, Marc-Emmanuel, additional, Dunning, Jake, additional, Fletcher, Tom, additional, Green, Christoper A., additional, Greenhalf, William, additional, Griffin, Julian L., additional, Gupta, Rishi K., additional, Harrison, Ewen M., additional, Hiscox, Julian A., additional, Wai Ho, Antonia Ying, additional, Horby, Peter W., additional, Ijaz, Samreen, additional, Khoo, Saye, additional, Law, Andrew, additional, Lewis, Matthew R., additional, Liggi, Sonia, additional, Lim, Wei Shen, additional, Maslen, Lynn, additional, Merson, Laura, additional, Meynert, Alison M., additional, Moore, Shona C., additional, Noursadeghi, Mahdad, additional, Olanipekun, Michael, additional, Osagie, Anthonia, additional, Palmarini, Massimo, additional, Palmieri, Carlo, additional, Paxton, William A., additional, Pollakis, Georgios, additional, Price, Nicholas, additional, Rambaut, Andrew, additional, Robertson, David L., additional, Russell, Clark D., additional, Sancho-Shimizu, Vanessa, additional, Sands, Caroline J., additional, Scott, Janet T., additional, Sigfrid, Louise, additional, Solomon, Tom, additional, Sriskandan, Shiranee, additional, Stuart, David, additional, Summers, Charlotte, additional, Swann, Olivia V., additional, Takats, Zoltan, additional, Takis, Panteleimon, additional, Tedder, Richard S., additional, Thompson, AA Roger, additional, Thomson, Emma C., additional, Thwaites, Ryan S., additional, Turtle, Lance CW., additional, Zambon, Maria, additional, Hardwick, Hayley, additional, Donohue, Chloe, additional, Griffiths, Fiona, additional, Oosthuyzen, Wilna, additional, Donegan, Cara, additional, Spencer, Rebecca G., additional, Norman, Lisa, additional, Pius, Riinu, additional, Drake, Thomas M., additional, Fairfield, Cameron J., additional, Knight, Stephen R., additional, Mclean, Kenneth A., additional, Murphy, Derek, additional, Shaw, Catherine A., additional, Dalton, Jo, additional, Girvan, Michelle, additional, Saviciute, Egle, additional, Roberts, Stephanie, additional, Harrison, Janet, additional, Marsh, Laura, additional, Connor, Marie, additional, Halpin, Sophie, additional, Jackson, Clare, additional, Gamble, Carrol, additional, Plotkin, Daniel, additional, Lee, James, additional, Leeming, Gary, additional, Wham, Murray, additional, Clohisey, Sara, additional, Hendry, Ross, additional, Scott-Brown, James, additional, Shaw, Victoria, additional, McDonald, Sarah E., additional, Keating, Seán, additional, Ahmed, Katie A., additional, Armstrong, Jane A., additional, Ashworth, Milton, additional, Asiimwe, Innocent G., additional, Bakshi, Siddharth, additional, Barlow, Samantha L., additional, Booth, Laura, additional, Brennan, Benjamin, additional, Bullock, Katie, additional, Catterall, Benjamin WA., additional, Clark, Jordan J., additional, Clarke, Emily A., additional, Cole, Sarah, additional, Cooper, Louise, additional, Cox, Helen, additional, Davis, Christopher, additional, Dincarslan, Oslem, additional, Dunn, Chris, additional, Dyer, Philip, additional, Elliott, Angela, additional, Evans, Anthony, additional, Finch, Lorna, additional, Fisher, Lewis WS., additional, Foster, Terry, additional, Garcia-Dorival, Isabel, additional, Gunning, Philip, additional, Hartley, Catherine, additional, Jensen, Rebecca L., additional, Jones, Christopher B., additional, Jones, Trevor R., additional, Khandaker, Shadia, additional, King, Katharine, additional, Kiy, Robyn T., additional, Koukorava, Chrysa, additional, Lake, Annette, additional, Lant, Suzannah, additional, Latawiec, Diane, additional, Lavelle-Langham, Lara, additional, Lefteri, Daniella, additional, Lett, Lauren, additional, Livoti, Lucia A., additional, Mancini, Maria, additional, McDonald, Sarah, additional, McEvoy, Laurence, additional, McLauchlan, John, additional, Metelmann, Soeren, additional, Miah, Nahida S., additional, Middleton, Joanna, additional, Mitchell, Joyce, additional, Murphy, Ellen G., additional, Penrice-Randal, Rebekah, additional, Pilgrim, Jack, additional, Prince, Tessa, additional, Reynolds, Will, additional, Ridley, P. Matthew, additional, Sales, Debby, additional, Shaw, Victoria E., additional, Shears, Rebecca K., additional, Small, Benjamin, additional, Subramaniam, Krishanthi S., additional, Szemiel, Agnieska, additional, Taggart, Aislynn, additional, Tanianis-Hughes, Jolanta, additional, Thomas, Jordan, additional, Trochu, Erwan, additional, van Tonder, Libby, additional, Wilcock, Eve, additional, Zhang, J. Eunice, additional, Flaherty, Lisa, additional, Maziere, Nicole, additional, Cass, Emily, additional, Carracedo, Alejandra Doce, additional, Carlucci, Nicola, additional, Holmes, Anthony, additional, Massey, Hannah, additional, Murphy, Lee, additional, McCafferty, Sarah, additional, Clark, Richard, additional, Fawkes, Angie, additional, Morrice, Kirstie, additional, Maclean, Alan, additional, Wrobel, Nicola, additional, Donnelly, Lorna, additional, Coutts, Audrey, additional, Hafezi, Katarzyna, additional, MacGillivray, Louise, additional, Gilchrist, Tammy, additional, Adeniji, Kayode, additional, Agranoff, Daniel, additional, Agwuh, Ken, additional, Ail, Dhiraj, additional, Aldera, Erin L., additional, Alegria, Ana, additional, Allen, Sam, additional, Angus, Brian, additional, Ashish, Abdul, additional, Atkinson, Dougal, additional, Bari, Shahedal, additional, Barlow, Gavin, additional, Barnass, Stella, additional, Barrett, Nicholas, additional, Bassford, Christopher, additional, Basude, Sneha, additional, Baxter, David, additional, Beadsworth, Michael, additional, Bernatoniene, Jolanta, additional, Berridge, John, additional, Berry, Colin, additional, Best, Nicola, additional, Bothma, Pieter, additional, Chadwick, David, additional, Brittain-Long, Robin, additional, Bulteel, Naomi, additional, Burden, Tom, additional, Burtenshaw, Andrew, additional, Caruth, Vikki, additional, Chambler, Duncan, additional, Chee, Nigel, additional, Child, Jenny, additional, Chukkambotla, Srikanth, additional, Clark, Tom, additional, Collini, Paul, additional, Cosgrove, Catherine, additional, Cupitt, Jason, additional, Cutino-Moguel, Maria-Teresa, additional, Dark, Paul, additional, Dawson, Chris, additional, Dervisevic, Samir, additional, Donnison, Phil, additional, Douthwaite, Sam, additional, Drummond, Andrew, additional, DuRand, Ingrid, additional, Dushianthan, Ahilanadan, additional, Dyer, Tristan, additional, Evans, Cariad, additional, Eziefula, Chi, additional, Fegan, Chrisopher, additional, Finn, Adam, additional, Fullerton, Duncan, additional, Garg, Sanjeev, additional, Garg, Atul, additional, Gkrania-Klotsas, Effrossyni, additional, Godden, Jo, additional, Goldsmith, Arthur, additional, Graham, Clive, additional, Hardy, Elaine, additional, Hartshorn, Stuart, additional, Harvey, Daniel, additional, Havalda, Peter, additional, Hawcutt, Daniel B., additional, Hobrok, Maria, additional, Hodgson, Luke, additional, Hormis, Anil, additional, Jacobs, Michael, additional, Jain, Susan, additional, Jennings, Paul, additional, Kaliappan, Agilan, additional, Kasipandian, Vidya, additional, Kegg, Stephen, additional, Kelsey, Michael, additional, Kendall, Jason, additional, Kerrison, Caroline, additional, Kerslake, Ian, additional, Koch, Oliver, additional, Koduri, Gouri, additional, Koshy, George, additional, Laha, Shondipon, additional, Laird, Steven, additional, Larkin, Susan, additional, Leiner, Tamas, additional, Lillie, Patrick, additional, Limb, James, additional, Linnett, Vanessa, additional, Little, Jeff, additional, Lyttle, Mark, additional, MacMahon, Michael, additional, MacNaughton, Emily, additional, Mankregod, Ravish, additional, Masson, Huw, additional, Matovu, Elijah, additional, McCullough, Katherine, additional, McEwen, Ruth, additional, Meda, Manjula, additional, Mills, Gary, additional, Minton, Jane, additional, Mirfenderesky, Mariyam, additional, Mohandas, Kavya, additional, Mok, Quen, additional, Moon, James, additional, Moore, Elinoor, additional, Morgan, Patrick, additional, Morris, Craig, additional, Mortimore, Katherine, additional, Moses, Samuel, additional, Mpenge, Mbiye, additional, Mulla, Rohinton, additional, Murphy, Michael, additional, Nagel, Megan, additional, Nagarajan, Thapas, additional, Nelson, Mark, additional, Norris, Lillian, additional, O’Shea, Matthew K., additional, Otahal, Igor, additional, Ostermann, Marlies, additional, Pais, Mark, additional, Panchatsharam, Selva, additional, Papakonstantinou, Danai, additional, Paraiso, Hassan, additional, Patel, Brij, additional, Pattison, Natalie, additional, Pepperell, Justin, additional, Peters, Mark, additional, Phull, Mandeep, additional, Pintus, Stefania, additional, Pooni, Jagtur Singh, additional, Planche, Tim, additional, Post, Frank, additional, Price, David, additional, Prout, Rachel, additional, Rae, Nikolas, additional, Reschreiter, Henrik, additional, Reynolds, Tim, additional, Richardson, Neil, additional, Roberts, Mark, additional, Roberts, Devender, additional, Rose, Alistair, additional, Rousseau, Guy, additional, Ruge, Bobby, additional, Ryan, Brendan, additional, Saluja, Taranprit, additional, Schmid, Matthias L., additional, Shah, Aarti, additional, Shanmuga, Prad, additional, Sharma, Anil, additional, Shawcross, Anna, additional, Sizer, Jeremy, additional, Shankar-Hari, Manu, additional, Smith, Richard, additional, Snelson, Catherine, additional, Spittle, Nick, additional, Staines, Nikki, additional, Stambach, Tom, additional, Stewart, Richard, additional, Subudhi, Pradeep, additional, Szakmany, Tamas, additional, Tatham, Kate, additional, Thomas, Jo, additional, Thompson, Chris, additional, Thompson, Robert, additional, Tridente, Ascanio, additional, Tupper-Carey, Darell, additional, Twagira, Mary, additional, Vallotton, Nick, additional, Vancheeswaran, Rama, additional, Vincent-Smith, Lisa, additional, Visuvanathan, Shico, additional, Vuylsteke, Alan, additional, Waddy, Sam, additional, Wake, Rachel, additional, Walden, Andrew, additional, Welters, Ingeborg, additional, Whitehouse, Tony, additional, Whittaker, Paul, additional, Whittington, Ashley, additional, Papineni, Padmasayee, additional, Wijesinghe, Meme, additional, Williams, Martin, additional, Wilson, Lawrence, additional, Winchester, Stephen, additional, Wiselka, Martin, additional, Wolverson, Adam, additional, Wootton, Daniel G., additional, Workman, Andrew, additional, Yates, Bryan, additional, and Young, Peter, additional

Published
2022
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27. Structures and therapeutic potential of anti-RBD human monoclonal antibodies against SARS-CoV-2

Author

Huang, Kuan-Ying A., primary, Zhou, Daming, additional, Tan, Tiong Kit, additional, Chen, Charles, additional, Duyvesteyn, Helen M. E., additional, Zhao, Yuguang, additional, Ginn, Helen M., additional, Qin, Ling, additional, Rijal, Pramila, additional, Schimanski, Lisa, additional, Donat, Robert, additional, Harding, Adam, additional, Gilbert-Jaramillo, Javier, additional, James, William, additional, Tree, Julia A., additional, Buttigieg, Karen, additional, Carroll, Miles, additional, Charlton, Sue, additional, Lien, Chia-En, additional, Lin, Meei-Yun, additional, Chen, Cheng-Pin, additional, Cheng, Shu-Hsing, additional, Chen, Xiaorui, additional, Lin, Tzou-Yien, additional, Fry, Elizabeth E., additional, Ren, Jingshan, additional, Ma, Che, additional, Townsend, Alain R., additional, and Stuart, David I., additional

Published
2022
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29. Correction: Breadth and function of antibody response to acute SARS-CoV-2 infection in humans

Author

Huang, Kuan-Ying A., primary, Tan, Tiong Kit, additional, Chen, Ting-Hua, additional, Huang, Chung-Guei, additional, Harvey, Ruth, additional, Hussain, Saira, additional, Chen, Cheng-Pin, additional, Harding, Adam, additional, Gilbert-Jaramillo, Javier, additional, Liu, Xu, additional, Knight, Michael, additional, Schimanski, Lisa, additional, Shih, Shin-Ru, additional, Lin, Yi-Chun, additional, Cheng, Chien-Yu, additional, Cheng, Shu-Hsing, additional, Huang, Yhu-Chering, additional, Lin, Tzou-Yien, additional, Jan, Jia-Tsrong, additional, Ma, Che, additional, James, William, additional, Daniels, Rodney S., additional, McCauley, John W., additional, Rijal, Pramila, additional, and Townsend, Alain R., additional

Published
2021
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30. Two doses of SARS-CoV-2 vaccination induce robust immune responses to emerging SARS-CoV-2 variants of concern

Author

Skelly, Donal T, Harding, Adam C, Gilbert-Jaramillo, Javier, Knight, Michael L, Longet, Stephanie, Brown, Anthony, Adele, Sandra, Adland, Emily, Brown, Helen, Chinnakannan, Senthil, Donnison, Timothy, Ali, Mohammad, Rongkard, Patpong, Pace, Matthew, Zacharopoulou, Peny, Robinson, Nicola, Csala, Anna, De Lara, Cathy, Hutchings, Claire L, Mehta, Hema, Lee, Lian Ni, Edmans, Matthew, Hackstein, Carl-Philipp, Phalora, Prabhjeet, Li, Wenqin, Phillips, Eloise, Malone, Tom, Ogbe, Ane, Jay, Cecilia, Tipoe, Timothy, Tipton, Tom, Stafford, Lizzie, Mentzer, Alexander J, Johnson, Sile A, Amini, Ali, Marjot, Thomas, Dimitriadis, Stavros, Simmons, Beatrice, Deeks, Alexandra, Kerneis, Sven, Abuelgasim, Hibatullah, Wilson, Robert, Thomas, Sarah R, Watson, Adam, Alhussni, Ahmed, Cutteridge, Joseph, Weeks, Esme, Denly, Lucy, Lillie, Katy, Holmes, Jennifer, Matthews, Philppa C, O'Donnell, Denise, Tan, Tiong Kit, Schimanski, Lisa, Huang, Kuan-Ying A, Rijal, Pramila, Turtle, Lance, de Silva, Thushan, Richter, Alex, Duncan, Christopher JA, Payne, Rebecca P, Moore, Shona C, Knight, Julian C, Cassar, Mark Philip, Raman, Betty, Neubauer, Stefan, Fries, Anastasia, Talbot, Nick P, Petousi, Nayia, Ho, Ling-Pei, Peng, Yanchun, Dong, Tao, Camara, Susana, Marinou, Spyridoula, Linder, Aline, Adlou, Syed, Kasanyinga, Mwila, Bridges-Webb, Alice, Hill, Jennifer, Silva-Reyes, Laura, Blackwell, Luke, Frater, John, Goulder, Philip, Conlon, Christopher P, Jeffery, Katie, Dold, Christina, Pollard, Andrew J, Sigal, Alex, de Oliveira, Tulio, Townsend, Alain R, Klenerman, Paul, Dunachie, Susanna J, Barnes, Eleanor, Carroll, Miles W, James, William S, Team, Medawar Lab, OPTIC, PITCH, and PHOSP

Subjects
COVID-19 Vaccines, T cell, viruses, Science, T-Lymphocytes, General Physics and Astronomy, Biology, Antibodies, Viral, General Biochemistry, Genetics and Molecular Biology, Neutralization, Epitope, Article, Epitopes, Immune system, Immunity, medicine, Animals, Humans, skin and connective tissue diseases, Vaccines, Multidisciplinary, SARS-CoV-2, fungi, Antibodies, Monoclonal, COVID-19, General Chemistry, Antimicrobial responses, biochemical phenomena, metabolism, and nutrition, Virology, Antibodies, Neutralizing, Vaccination, body regions, medicine.anatomical_structure, Immunization, biology.protein, Angiotensin-Converting Enzyme 2, Antibody, Pathogens, Carrier Proteins
Abstract

The extent to which immune responses to natural infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and immunization with vaccines protect against variants of concern (VOC) is of increasing importance. Accordingly, here we analyse antibodies and T cells of a recently vaccinated, UK cohort, alongside those recovering from natural infection in early 2020. We show that neutralization of the VOC compared to a reference isolate of the original circulating lineage, B, is reduced: more profoundly against B.1.351 than for B.1.1.7, and in responses to infection or a single dose of vaccine than to a second dose of vaccine. Importantly, high magnitude T cell responses are generated after two vaccine doses, with the majority of the T cell response directed against epitopes that are conserved between the prototype isolate B and the VOC. Vaccination is required to generate high potency immune responses to protect against these and other emergent variants., Understanding the effect of vaccination on emerging SARS-CoV-2 variants of concern is of increasing importance. Here, James et al. report that two doses of vaccination with the Pfizer-BioNTech vaccine induce more robust immune responses to the B.1.1.7 and B.1.351 SARS-CoV-2 lineages than does natural infection.

Published
2021

34. Correction: Protective porcine influenza virus-specific monoclonal antibodies recognize similar haemagglutinin epitopes as humans

Author

Holzer, Barbara, primary, Rijal, Pramila, additional, McNee, Adam, additional, Paudyal, Basudev, additional, Martini, Veronica, additional, Clark, Becky, additional, Manjegowda, Tanuja, additional, Salguero, Francisco J., additional, Bessell, Emily, additional, Schwartz, John C., additional, Moffat, Katy, additional, Pedrera, Miriam, additional, Graham, Simon P., additional, Noble, Alistair, additional, Placido, Marie Bonnet-Di, additional, La Ragione, Roberto M., additional, Mwangi, William, additional, Beverley, Peter, additional, McCauley, John W., additional, Daniels, Rodney S., additional, Hammond, John A., additional, Townsend, Alain R., additional, and Tchilian, Elma, additional

Published
2021
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35. Hepcidin-mediated hypoferremia disrupts immune\ud responses to vaccination and infection

Author

Frost, Joe N., Kit Tan, Tiong, Abbas, Munawar, Wideman, Sarah K., Bonadonna, Michael, Stoffel, Nicole U., Weay, Katherine, Kronsteiner, Barbara, Sits, Gabby, Campagna, Dean R., Duarte, Tiago L., Lopes, Jose M., Shah, Akshay, Armitage, Andrew E., Arezes, Joao, Jin Lim, Pei, Preston, Alexandra E., Ahem, David, Teh, Megan, Naylor, Caitlin, Salio, Mariolina, Gileadi, Uzi, Andrews, Simon C., Dunachie, Susanna J., Zimmermann, Michael B., van der Klis, Fiona R. M., Cerundolo, Vincenzo, Bannard, Oliver, Draper, Simon J., Townsend, Alain R. M., Galy, Bruno, Flamming, Mark D., Lewis, Marie C., and Drakesmith, Hal

Abstract

Background: How specific nutrients influence adaptive immunity is of\ud broad interest. Iron deficiency is the most common micronutrient deficiency worldwide and imparts a significant burden of global disease;\ud however, its effects on immunity remain unclear.\ud Methods: We used a hepcidin mimetic and several genetic models to\ud examine the effect of low iron availability on T cells in vitro and on immune responses to vaccines and viral infection in mice. We examined\ud humoral immunity in human patients with raised hepcidin and low\ud serum iron caused by mutant TMPRSS6. We tested the effect of iron\ud supplementation on vaccination-induced humoral immunity in piglets,\ud a natural model of iron deficiency.\ud Findings: We show that low serum iron (hypoferremia), caused by\ud increased hepcidin, severely impairs effector and memory responses\ud to immunizations. The intensified metabolism of activated lymphocytes\ud requires the support of enhanced iron acquisition, which is facilitated by\ud IRP1/2 and TFRC. Accordingly, providing extra iron improved the\ud response to vaccination in hypoferremic mice and piglets, while\ud conversely, hypoferremic humans with chronically increased hepcidin\ud have reduced concentrations of antibodies specific for certain pathogens. Imposing hypoferremia blunted the T cell, B cell, and neutralizing\ud antibody responses to influenza virus infection in mice, allowing the virus to persist and exacerbating lung inflammation and morbidity.\ud Conclusions: Hypoferremia, a well-conserved physiological innate\ud response to infection, can counteract the development of adaptive immunity. This nutrient trade-off is relevant for understanding and\ud improving immune responses to infections and vaccines in the globally\ud common contexts of iron deficiency and inflammatory disorders.

Published
2021

36. The antigenic anatomy of SARS-CoV-2 receptor binding domain

Author

Dejnirattisai, Wanwisa, primary, Zhou, Daming, additional, Ginn, Helen M., additional, Duyvesteyn, Helen M.E., additional, Supasa, Piyada, additional, Case, James Brett, additional, Zhao, Yuguang, additional, Walter, Thomas S., additional, Mentzer, Alexander J., additional, Liu, Chang, additional, Wang, Beibei, additional, Paesen, Guido C., additional, Slon-Campos, Jose, additional, López-Camacho, César, additional, Kafai, Natasha M., additional, Bailey, Adam L., additional, Chen, Rita E., additional, Ying, Baoling, additional, Thompson, Craig, additional, Bolton, Jai, additional, Fyfe, Alex, additional, Gupta, Sunetra, additional, Tan, Tiong Kit, additional, Gilbert-Jaramillo, Javier, additional, James, William, additional, Knight, Michael, additional, Carroll, Miles W., additional, Skelly, Donal, additional, Dold, Christina, additional, Peng, Yanchun, additional, Levin, Robert, additional, Dong, Tao, additional, Pollard, Andrew J., additional, Knight, Julian C., additional, Klenerman, Paul, additional, Temperton, Nigel, additional, Hall, David R., additional, Williams, Mark A., additional, Paterson, Neil G., additional, Bertram, Felicity K.R., additional, Siebert, C. Alistair, additional, Clare, Daniel K., additional, Howe, Andrew, additional, Radecke, Julika, additional, Song, Yun, additional, Townsend, Alain R., additional, Huang, Kuan-Ying A., additional, Fry, Elizabeth E., additional, Mongkolsapaya, Juthathip, additional, Diamond, Michael S., additional, Ren, Jingshan, additional, Stuart, David I., additional, and Screaton, Gavin R., additional

Published
2021
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37. Protective porcine influenza virus-specific monoclonal antibodies recognize similar haemagglutinin epitopes as humans

Author

Holzer, Barbara, primary, Rijal, Pramila, additional, McNee, Adam, additional, Paudyal, Basudev, additional, Martini, Veronica, additional, Clark, Becky, additional, Manjegowda, Tanuja, additional, Salguero, Francisco J., additional, Bessell, Emily, additional, Schwartz, John C., additional, Moffat, Katy, additional, Pedrera, Miriam, additional, Graham, Simon P., additional, Noble, Alistair, additional, Bonnet-Di Placido, Marie, additional, La Ragione, Roberto M., additional, Mwangi, William, additional, Beverley, Peter, additional, McCauley, John W., additional, Daniels, Rodney S., additional, Hammond, John A., additional, Townsend, Alain R., additional, and Tchilian, Elma, additional

Published
2021
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38. Breadth and function of antibody response to acute SARS-CoV-2 infection in humans

Author

Huang, Kuan-Ying A., primary, Tan, Tiong Kit, additional, Chen, Ting-Hua, additional, Huang, Chung-Guei, additional, Harvey, Ruth, additional, Hussain, Saira, additional, Chen, Cheng-Pin, additional, Harding, Adam, additional, Gilbert-Jaramillo, Javier, additional, Liu, Xu, additional, Knight, Michael, additional, Schimanski, Lisa, additional, Shih, Shin-Ru, additional, Lin, Yi-Chun, additional, Cheng, Chien-Yu, additional, Cheng, Shu-Hsing, additional, Huang, Yhu-Chering, additional, Lin, Tzou-Yien, additional, Jan, Jia-Tsrong, additional, Ma, Che, additional, James, William, additional, Daniels, Rodney S., additional, McCauley, John W., additional, Rijal, Pramila, additional, and Townsend, Alain R., additional

Published
2021
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39. Natural and vaccine-induced antibody and cellular responses against emerging SARS-CoV-2 variants of concern

Author

Skelly, Donal T., primary, Harding, Adam C., additional, Gilbert-Jaramillo, Javier, additional, Knight, Michael L., additional, Longet, Stephanie, additional, Brown, Anthony, additional, Adele, Sandra, additional, Adland, Emily, additional, Brown, Helen, additional, Team, Medawar Laboratory, additional, Tipton, Tom, additional, Stafford, Lizzie, additional, Johnson, Síle A., additional, Amini, Ali, additional, Group, OPTIC Clinical, additional, Tan, Tiong Kit, additional, Schimanski, Lisa, additional, Huang, Kuan-Ying A., additional, Rijal, Pramila, additional, Group, PITCH Study, additional, Oxford, University of, additional, Frater, John, additional, Goulder, Philip, additional, Conlon, Chris, additional, Jeffery, Katie, additional, Dold, Christina, additional, Pollard, Andrew J., additional, Townsend, Alain R., additional, Klenerman, Paul, additional, Dunachie, Susanna J., additional, Barnes, Eleanor, additional, Carroll, Miles W., additional, and James, William, additional

Published
2021
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40. Recognition of Z-RNA by ADAR1 limits interferon responses

Author

Tang, Qiannan, primary, Rigby, Rachel E., additional, Young, George R., additional, Korning-Hvidt, Astrid, additional, Tan, Tiong Kit, additional, Bridgeman, Anne, additional, Townsend, Alain R., additional, Kassiotis, George, additional, and Rehwinkel, Jan, additional

Published
2020
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42. Structure-Based Modification of an Anti-neuraminidase Human Antibody Restores Protection Efficacy against the Drifted Influenza Virus

Author

Jiang, Haihai, primary, Peng, Weiyu, additional, Qi, Jianxun, additional, Chai, Yan, additional, Song, Hao, additional, Bi, Yuhai, additional, Rijal, Pramila, additional, Wang, Haiyuan, additional, Oladejo, Babayemi O., additional, Liu, Jinhua, additional, Shi, Yi, additional, Gao, George F., additional, Townsend, Alain R., additional, and Wu, Yan, additional

Published
2020
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43. A COVID-19 vaccine candidate using SpyCatcher multimerization of the SARS-CoV-2 spike protein receptor-binding domain induces potent neutralising antibody responses

Author

Tan, Tiong Kit, primary, Rijal, Pramila, additional, Rahikainen, Rolle, additional, Keeble, Anthony H., additional, Schimanski, Lisa, additional, Hussain, Saira, additional, Harvey, Ruth, additional, Hayes, Jack W.P., additional, Edwards, Jane. C., additional, McLean, Rebecca K., additional, Martini, Veronica, additional, Pedrera, Miriam, additional, Thakur, Nazia, additional, Conceicao, Carina, additional, Dietrich, Isabelle, additional, Shelton, Holly, additional, Ludi, Anna, additional, Wilsden, Ginette, additional, Browning, Clare, additional, Zagrajek, Adrian K., additional, Bialy, Dagmara, additional, Bhat, Sushant, additional, Stevenson-Leggett, Phoebe, additional, Hollinghurst, Philippa, additional, Tully, Matthew, additional, Moffat, Katy, additional, Chiu, Chris, additional, Waters, Ryan, additional, Gray, Ashley, additional, Azhar, Mehreen, additional, Mioulet, Valerie, additional, Newman, Joseph, additional, Asfor, Amin S., additional, Burman, Alison, additional, Crossley, Sylvia, additional, Hammond, John A., additional, Tchilian, Elma, additional, Charleston, Bryan, additional, Bailey, Dalan, additional, Tuthill, Tobias J., additional, Graham, Simon P., additional, Malinauskas, Tomas, additional, Huo, Jiandong, additional, Tree, Julia A., additional, Buttigieg, Karen R., additional, Owens, Raymond J., additional, Caroll, Miles W., additional, Daniels, Rodney S., additional, McCauley, John W., additional, Huang, Kuan-Ying A., additional, Howarth, Mark, additional, and Townsend, Alain R., additional

Published
2020
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44. Breadth and function of antibody response to acute SARS-CoV-2 infection in humans

Author

Huang, Kuan-Ying A., primary, Tan, Tiong Kit, additional, Chen, Ting-Hua, additional, Huang, Chung-Guei, additional, Harvey, Ruth, additional, Hussain, Saira, additional, Chen, Cheng-Pin, additional, Harding, Adam, additional, Gilbert-Jaramillo, Javier, additional, Liu, Xu, additional, Knight, Michael, additional, Schimanski, Lisa, additional, Shih, Shin-Ru, additional, Lin, Yi-Chun, additional, Cheng, Chien-Yu, additional, Cheng, Shu-Hsing, additional, Huang, Yhu-Chering, additional, Lin, Tzou-Yien, additional, Jan, Jia-Tsrong, additional, Ma, Che, additional, James, William, additional, Daniels, Rodney S., additional, McCauley, John W., additional, Rijal, Pramila, additional, and Townsend, Alain R., additional

Published
2020
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45. Protective porcine influenza virus-specific monoclonal antibodies recognize similar haemagglutinin epitopes as humans

Author

Holzer, Barbara, primary, Rijal, Pramila, additional, McNee, Adam, additional, Paudyal, Basu, additional, Clark, Becky, additional, Manjegowda, Tanuja, additional, Salguero, Francisco J., additional, Bessell, Emily, additional, Schwartz, John C., additional, Moffat, Katy, additional, Pedrera, Miriam, additional, Graham, Simon P., additional, Placido, Marie Bonnet-Di, additional, La Ragione, Roberto M., additional, Mwangi, William, additional, Beverley, Peter, additional, McCauley, John W., additional, Daniels, Rodney S., additional, Hammond, John, additional, Townsend, Alain R., additional, and Tchilian, Elma, additional

Published
2020
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48. Semaphorin 3A induces cytoskeletal paralysis in tumor-specific CD8+ T cells

Author

Barnkob, Mike B, primary, Michaels, Yale S, additional, André, Violaine, additional, Macklin, Philip S, additional, Gileadi, Uzi, additional, Valvo, Salvatore, additional, Rei, Margarida, additional, Kulicke, Corinna, additional, Chen, Ji-Li, additional, Jain, Vitul, additional, Woodcock, Victoria, additional, Colin-York, Huw, additional, Hadjinicolaou, Andreas V, additional, Kong, Youxin, additional, Mayya, Viveka, additional, Bull, Joshua A, additional, Rijal, Pramila, additional, Pugh, Christopher W, additional, Townsend, Alain R, additional, Olsen, Lars R, additional, Fritzsche, Marco, additional, Fulga, Tudor A, additional, Dustin, Michael L, additional, Jones, E Yvonne, additional, and Cerundolo, Vincenzo, additional

Published
2019
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50. Therapeutic Monoclonal Antibodies for Ebola Virus Infection Derived from Vaccinated Humans

Author

Rijal, Pramila, primary, Elias, Sean C., additional, Machado, Samara Rosendo, additional, Xiao, Julie, additional, Schimanski, Lisa, additional, O’Dowd, Victoria, additional, Baker, Terry, additional, Barry, Emily, additional, Mendelsohn, Simon C., additional, Cherry, Catherine J., additional, Jin, Jing, additional, Labbé, Geneviève M., additional, Donnellan, Francesca R., additional, Rampling, Tommy, additional, Dowall, Stuart, additional, Rayner, Emma, additional, Findlay-Wilson, Stephen, additional, Carroll, Miles, additional, Guo, Jia, additional, Xu, Xiao-Ning, additional, Huang, Kuan-Ying A., additional, Takada, Ayato, additional, Burgess, Gillian, additional, McMillan, David, additional, Popplewell, Andy, additional, Lightwood, Daniel J., additional, Draper, Simon J., additional, and Townsend, Alain R., additional

Published
2019
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