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1. Psychiatric and physical outcomes of long-term use of lithium in older adults with bipolar disorder and major depressive disorder: A cross-sectional multicenter study

Author

Adès, J, Alezrah, C, Amado, I, Amar, G, Andréi, O, Arbault, D, Archambault, G, Aurifeuille, G, Barrière, S, Béra-Potelle, C, Blumenstock, Y, Bardou, H, Bareil-Guérin, M, Barrau, P, Barrouillet, C, Baup, E, Bazin, N, Beaufils, B, Ben Ayed, J, Benoit, M, Benyacoub, K, Bichet, T, Blanadet, F, Blanc, O, Blanc-Comiti, J, Boussiron, D, Bouysse, AM, Brochard, A, Brochart, O, Bucheron, B, Cabot, M, Camus, V, Chabannes, JM, Charlot, V, Charpeaud, T, Clad-Mor, C, Combes, C, Comisu, M, Cordier, B, Costi, F, Courcelles, JP, Creixell, M, Cuche, H, Cuervo-Lombard, C, Dammak, A, Da Rin, D, Denis, JB, Denizot, H, Deperthuis, A, Diers, E, Dirami, S, Donneau, D, Dreano, P, Dubertret, C, Duprat, E, Duthoit, D, Fernandez, C, Fonfrede, P, Freitas, N, Gasnier, P, Gauillard, J, Getten, F, Gierski, F, Godart, F, Gourevitch, R, Grassin Delyle, A, Gremion, J, Gres, H, Griner, V, Guerin-Langlois, C, Guggiari, C, Guillin, O, Hadaoui, H, Haffen, E, Hanon, C, Haouzir, S, Hazif-Thomas, C, Heron, A, Hubsch, B, Jalenques, I, Januel, D, Kaladjian, A, Karnycheff, JF, Kebir, O, Krebs, MO, Lajugie, C, Leboyer, M, Legrand, P, Lejoyeux, M, Lemaire, V, Leroy, E, Levy-Chavagnat, D, Leydier, A, Liling, C, Llorca, PM, Loeffel, P, Louville, P, Lucas Navarro, S, Mages, N, Mahi, M, Maillet, O, Manetti, A, Martelli, C, Martin, P, Masson, M, Maurs-Ferrer, I, Mauvieux, J, Mazmanian, S, Mechin, E, Mekaoui, L, Meniai, M, Metton, A, Mihoubi, A, Miron, M, Mora, G, Niro Adès, V, Nubukpo, P, Omnes, C, Papin, S, Paris, P, Passerieux, C, Pellerin, J, Perlbarg, J, Perron, S, Petit, A, Petitjean, F, Portefaix, C, Pringuey, D, Radtchenko, A, Rahiou, H, Raucher-Chéné, D, Rauzy, A, Reinheimer, L, Renard, M, René, M, Rengade, CE, Reynaud, P, Robin, D, Rodrigues, C, Rollet, A, Rondepierre, F, Rousselot, B, Rubingher, S, Saba, G, Salvarelli, JP, Samuelian, JC, Scemama-Ammar, C, Schurhoff, F, Schuster, JP, Sechter, D, Segalas, B, Seguret, T, Seigneurie, AS, Semmak, A, Slama, F, Taisne, S, Taleb, M, Terra, JL, Thefenne, D, Tran, E, Tourtauchaux, R, Vacheron, MN, Vandel, P, Vanhoucke, V, Venet, E, Verdoux, H, Viala, A, Vidon, G, Vitre, M, Vurpas, JL, Wagermez, C, Walter, M, Yon, L, Zendjidjian, X., Morlet, Elise, Costemale-Lacoste, Jean-François, Poulet, Emmanuel, McMahon, Kibby, Hoertel, Nicolas, and Limosin, Frédéric

Published
2019
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2. Effects of depression and cognitive impairment on quality of life in older adults with schizophrenia spectrum disorder: Results from a multicenter study

Author

Adès, J., Alezrah, C., Amado, I., Amar, G., Andréi, O., Arbault, D., Archambault, G., Aurifeuille, G., Barrière, S., Béra-Potelle, C., Blumenstock, Y., Bardou, H., Bareil-Guérin, M., Barrau, P., Barrouillet, C., Baup, E., Bazin, N., Beaufils, B., Ben Ayed, J., Benoit, M., Benyacoub, K., Bichet, T., Blanadet, F., Blanc, O., Blanc-Comiti, J., Boussiron, D., Bouysse, A.M., Brochard, A., Brochart, O., Bucheron, B., Cabot, M., Camus, V., Chabannes, J.M., Charlot, V., Charpeaud, T., Clad-Mor, C., Combes, C., Comisu, M., Cordier, B., Costi, F., Courcelles, J.P., Creixell, M., Cuche, H., Cuervo-Lombard, C., Dammak, A., Da Rin, D., Denis, J.B., Denizot, H., Deperthuis, A., Diers, E., Dirami, S., Donneau, D., Dreano, P., Dubertret, C., Duprat, E., Duthoit, D., Fernandez, C., Fonfrede, P., Freitas, N., Gasnier, P., Gauillard, J., Getten, F., Gierski, F., Godart, F., Gourevitch, R., Grassin Delyle, A., Gremion, J., Gres, H., Griner, V., Guerin-Langlois, C., Guggiari, C., Guillin, O., Hadaoui, H., Haffen, E., Hanon, C., Haouzir, S., Hazif-Thomas, C., Heron, A., Hoertel, N., Hubsch, B., Jalenques, I., Januel, D., Kaladjian, A., Karnycheff, J.F., Kebir, O., Krebs, M.O., Lajugie, C., Leboyer, M., Legrand, P., Lejoyeux, M., Lemaire, V., Leroy, E., Levy-Chavagnat, D., Leydier, A., Liling, C., Limosin, F., Llorca, P.M., Loeffel, P., Louville, P., Lucas Navarro, S., Mages, N., Mahi, M., Maillet, O., Manetti, A., Martelli, C., Martin, P., Masson, M., Maurs-Ferrer, I., Mauvieux, J., Mazmanian, S., Mechin, E., Mekaoui, L., Meniai, M., Metton, A., Mihoubi, A., Miron, M., Mora, G., Niro Adès, V., Nubukpo, P., Omnes, C., Papin, S., Paris, P., Passerieux, C., Pellerin, J., Perlbarg, J., Perron, S., Petit, A., Petitjean, F., Portefaix, C., Pringuey, D., Radtchenko, A., Rahiou, H., Raucher-Chéné, D., Rauzy, A., Reinheimer, L., Renard, M., René, M., Rengade, C.E., Reynaud, P., Robin, D., Rodrigues, C., Rollet, A., Rondepierre, F., Rousselot, B., Rubingher, S., Saba, G., Salvarelli, J.P., Samuelian, J.C., Scemama-Ammar, C., Schurhoff, F., Schuster, J.P., Sechter, D., Segalas, B., Seguret, T., Seigneurie, A.S., Semmak, A., Slama, F., Taisne, S., Taleb, M., Terra, J.L., Thefenne, D., Tran, E., Tourtauchaux, R., Vacheron, M.N., Vandel, P., Vanhoucke, V., Venet, E., Verdoux, H., Viala, A., Vidon, G., Vitre, M., Vurpas, J.L., Wagermez, C., Walter, M., Yon, L., Zendjidjian, X., Pascal de Raykeer, Rachel, Hoertel, Nicolas, Blanco, Carlos, Lavaud, Pierre, Kaladjian, Arthur, Blumenstock, Yvonne, Cuervo-Lombard, Christine-Vanessa, Peyre, Hugo, Lemogne, Cédric, and Limosin, Frédéric

Published
2019
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11. Late-onset and nonlate-onset schizophrenia: A comparison of clinical characteristics in a multicenter study

Author

Passerieux, C., Pellerin, J., Perlbarg, J., Perron, S., Petit, A., Petitjean, F., Portefaix, C., Pringuey, D., Radtchenko, A., Rahiou, H., Raucher-Chene, D., Rauzy, A., Reinheimer, L., Renard, M., Rene, M., Rengade, C. E., Reynaud, P., Robin, D., Rodrigues, C., Rollet, A., Rondepierre, F., Rousselot, B., Rubingher, S., Saba, G., Salvarelli, J. P., Samuelian, J. C., Scemama-Ammar, C., Schurhoff, F., Schuster, J. P., Sechter, D., Segalas, B., Seguret, T., Seigneurie, A. S., Semmak, A., Slama, F., Taisne, S., Taleb, M., Terra, J. L., Thefenne, D., Tran, E., Tourtauchaux, R., Vacheron, M. N., Vanhoucke, V., Venet, E., Verdoux, H., Viala, A., Vidon, G., Vitre, M., Vurpas, J. L., Wagermez, C., Walter, M., Zendjidjian, X., Abou Kassm, Sandra, Limosin, Frederic, Naja, Wadih, Vandel, Pierre, Sanchez-Rico, Marina, Alvarado, Jesus M., Gunten, Armin, Hoertel, Nicolas, Ades, J., Alezrah, C., Amado, I, Amar, G., Andrei, O., Arbault, D., Archambault, G., Aurifeuille, G., Barriere, S., Bera-Potelle, C., Blumenstock, Y., Bardou, H., Bareil-Guerin, M., Barrau, P., Barrouillet, C., Baup, E., Bazin, N., Beaufils, B., Ben Ayed, J., Benoit, M., Benyacoub, K., Bichet, T., Blanadet, F., Blanc, O., Blanc-Comiti, J., Boussiron, D., Bouysse, A. M., Brochard, A., Brochart, O., Bucheron, B., Cabot, M., Camus, V, Chabannes, J. M., Charlot, V, Charpeaud, T., Clad-Mor, C., Combes, C., Comisu, M., Cordier, B., Costi, F., Courcelles, J. P., Creixell, M., Cuche, H., Cuervo-Lombard, C., Dammak, A., da Rin, D., Denis, J. B., Denizot, H., Deperthuis, A., Diers, E., Dirami, S., Donneau, D., Dreano, P., Dubertret, C., Duprat, E., Duthoit, D., Fernandez, C., Fonfrede, P., Freitas, N., Gasnier, P., Gauillard, J., Getten, F., Gierski, Fabien, Godart, F., Gourevitch, R., Delyle, Grassin A., Gremion, J., Gres, H., Griner, V, Guerin-Langlois, C., Guggiari, C., Guillin, O., Hadaoui, H., Haffen, E., Haouzir, S., Hanon, C., Hazif-Thomas, C., Heron, A., Hubsch, B., Jalenques, I, Januel, D., Kaladjian, A., Karnycheff, J. F., Kebir, O., Krebs, M. O., Lajugie, C., Leboyer, M., Legrand, P., Lejoyeux, M., Lemaire, V, Leroy, E., Levy-Chavagnat, D., Leydier, A., Liling, C., Llorca, P. M., Loeffel, P., Louville, P., Navarro, Lucas S., Mages, N., Mahi, M., Maillet, O., Manetti, A., Martelli, C., Martin, P., Masson, M., Maurs-Ferrer, I, Mauvieux, J., Mazmanian, S., Mechin, E., Mekaoui, L., Meniai, M., Metton, A., Mihoubi, A., Miron, M., Mora, G., Ades, Niro, Nubukpo, P., Omnes, C., Papin, S., Paris, P., Fondation FondaMental [Créteil], Weizenbaum Institut [Berlin], Monash University [Clayton], Centre de Recherche en Sciences et Technologies de l'Information et de la Communication - EA 3804 (CRESTIC), Université de Reims Champagne-Ardenne (URCA), Clinique de Psychiatrie et de Psychologie Médicale, Hôpital Pasteur, Nice, France, Centre Hospitalier Universitaire de Nice (CHU Nice), Cognition, Santé, Société (C2S), Université de Reims Champagne-Ardenne (URCA)-SFR CAP Santé (Champagne-Ardenne Picardie Santé), Université de Reims Champagne-Ardenne (URCA)-Université de Reims Champagne-Ardenne (URCA)-Maison des Sciences Humaines de Champagne-Ardenne (MSH-URCA), Department of Engineering Cybernetics [Trondheim] (ITK NTNU), Norwegian University of Science and Technology [Trondheim] (NTNU), Norwegian University of Science and Technology (NTNU)-Norwegian University of Science and Technology (NTNU), Agence nationale de la sécurité des systèmes d'information (ANSSI), Jeune Equipe Hémopathogènes Vectorisés, VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS), Silicon-on-Insulator Technologies (SOITEC), Parc Technologique des Fontaines, Recherches en Psychopathologie, nouveaux symptômes et lien social (EA 4050), Université de Poitiers-Université de Brest (UBO)-Université Catholique de l'Ouest (UCO)-Université de Rennes 2 (UR2), Research Center for Biosciences and Health Technologies [Lisboa] (CBIOS), Universidade Lusófona's, PHysicochimie des Electrolytes et Nanosystèmes InterfaciauX (PHENIX), Institut de Chimie du CNRS (INC)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Modélisation de la matière condensée et des interfaces (MMCI), Institut Lumière Matière [Villeurbanne] (ILM), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Kantar – Health Division, Partenaires INRAE, Institut National de la Santé et de la Recherche Médicale (INSERM), Neuro-Psycho Pharmacologie des Systèmes Dopimanégiques sous-corticaux (NPsy-Sydo), CHU Clermont-Ferrand-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Institut de biologie et chimie des protéines [Lyon] (IBCP), Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Soins Primaires, Santé Publique, Registre des cancers de Bretagne Occidentale (EA7479 SPURBO), Université de Brest (UBO)-Centre Hospitalier Régional Universitaire de Brest (CHRU Brest)-Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO)-Université de Brest (UBO), Service de Psychiatrie, Hôpital de la Conception, Piici, UMR 7298, Aix-Marseille Université-CNRS, Marseille, France, Hôpital Corentin Celton [Issy-les-Moulineaux], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Département de psychiatrie [CHRU de Besançon], Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Institut de psychiatrie et neurosciences de Paris (IPNP - U1266 Inserm), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), PELLENC S.A., Franche-Comté Électronique Mécanique, Thermique et Optique - Sciences et Technologies (UMR 6174) (FEMTO-ST), Université de Technologie de Belfort-Montbeliard (UTBM)-Ecole Nationale Supérieure de Mécanique et des Microtechniques (ENSMM)-Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Laboratoire d'Informatique Fondamentale de Lille (LIFL), Université de Lille, Sciences et Technologies-Institut National de Recherche en Informatique et en Automatique (Inria)-Université de Lille, Sciences Humaines et Sociales-Centre National de la Recherche Scientifique (CNRS), French Society for Biological Psychiatry and Neuropsychopharmacology, CHU Clermont-Ferrand, Imagerie et cerveau (iBrain - Inserm U1253 - UNIV Tours ), Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre interuniversitaire de recherche et d'ingenierie des matériaux (CIRIMAT), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT), Hôpital Foch [Suresnes], Università degli studi di Genova = University of Genoa (UniGe), Unité de recherche Mathématiques et Informatique Appliquées (MIA), Institut National de la Recherche Agronomique (INRA), Fédération Française de Triathlon (FFTRI), AP-HP, Groupe Hospitalo-Universitaire AP-HP Nord, DMU ESPRIT, service de Psychiatrie et Addictologie, Hôpital Louis Mourier, Colombes, Inserm U1266, 178, rue des Renouillers, 92700 Colombes, France, UFR de Médecine Paris Nord, Université de Paris, 16, rue Henri Huchard, 75018 Paris, France., Institut de génétique humaine (IGH), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Commissariat à l'énergie atomique et aux énergies alternatives - Laboratoire d'Electronique et de Technologie de l'Information (CEA-LETI), Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Groupe de Recherche sur l'alcool et les pharmacodépendances - UMR INSERM_S 1247 (GRAP), Université de Picardie Jules Verne (UPJV)-Institut National de la Santé et de la Recherche Médicale (INSERM), Génomique et Médecine Personnalisée du Cancer et des Maladies Neuropsychiatriques (GPMCND), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service hospitalo-universitaire, centre hospitalier du Rouvray, 4, rue Paul-Eluard, 76300 Sotteville-lès-Rouen, France., CHRU Brest - Psychiatrie Adulte (CHU - Brest- Psychiatrie), Centre de Physique Théorique [Palaiseau] (CPHT), École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Unité de recherche clinique 93G03, établissement public de santé de Ville Evrard, 93330 Neuilly-sur-Marne, France., Laboratoire de Physique des Lasers (LPL), Université Paris 13 (UP13)-Centre National de la Recherche Scientifique (CNRS), Groupement de recherche en Psychiatrie (GDR Psychiatrie (3557)), Centre National de la Recherche Scientifique (CNRS), Université Paris Cité (UPCité), Synchrotron SOLEIL (SSOLEIL), Animal, Santé, Territoires, Risques et Ecosystèmes (UMR ASTRE), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), CEA-Direction des Energies (ex-Direction de l'Energie Nucléaire) (CEA-DES (ex-DEN)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Université Paris Descartes - Faculté de Médecine (UPD5 Médecine), Université Paris Descartes - Paris 5 (UPD5), CB - Centre Borelli - UMR 9010 (CB), Service de Santé des Armées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Ecole Normale Supérieure Paris-Saclay (ENS Paris Saclay)-Université Paris Cité (UPCité), Hôpital Paul Brousse, Digitéo, Génétique Animale et Biologie Intégrative (GABI), AgroParisTech-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), RiverLy - Fonctionnement des hydrosystèmes (RiverLy), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Sonatrach Exploration, and Centre Hospitalier Victor Jousselin de Dreux

Subjects
Psychosis, Pediatrics, medicine.medical_specialty, business.industry, [SDV]Life Sciences [q-bio], Late onset, Schizoaffective disorder, Comorbidity, Odds ratio, medicine.disease, Psychiatry and Mental health, Cross-Sectional Studies, Psychotic Disorders, Quality of life, Schizophrenia, Quality of Life, medicine, Humans, Geriatrics and Gerontology, business, Aged, Diagnosis of schizophrenia
Abstract

International audience; Objectives Data are scarce regarding the potential clinical differences between non-late onset schizophrenia (NLOS, i.e., disorder occurring before 40 years of age), late-onset schizophrenia (LOS, occurring between ages 40 and 60 years) and very-late-onset schizophrenia-like psychosis (VLOSLP, occurring after 60 years of age). Furthermore, previous research compared LOS patients with non-age matched NLOS patients. In this study, we sought to examine potential clinical differences between patients of similar age with LOS and NLOS. Methods/Design This is a cross-sectional multicentre study that recruited in- and outpatients older adults (aged >= 55 years) with an ICD-10 diagnosis of schizophrenia or schizoaffective disorder with NLOS and LOS. Sociodemographic and clinical characteristics, comorbidity, psychotropic medications, quality of life, functioning, and mental health care utilization were drawn for comparison. Results Two hundred seventy-two participants (79.8%) had NLOS, 61 (17.9%) LOS, and 8 (2.3%) VLOSLP. LOS was significantly and independently associated with greater severity of emotional withdrawal and lower severity of depression (all p < 0.05). However, the magnitude of these associations was modest, with significant adjusted odds ratios ranging from 0.71 to 1.24, and there were no significant between-group differences in other characteristics. Conclusion In an age-matched multicenter sample of elderly patients with schizophrenia, older adults with LOS were largely similar to older adults with NLOS in terms of clinical characteristics. The few differences observed may be at least partially related to symptom fluctuation with time. Implications of these findings for pharmacological and nonpharmacological management is yet to be determined.

Published
2021
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18. Psychiatric symptoms and quality of life in older adults with schizophrenia spectrum disorder: results from a multicenter study

Author

Pascal de Raykeer, Rachel, Hoertel, Nicolas, Blanco, Carlos, Lavaud, Pierre, Kaladjian, Arthur, Blumenstock, Yvonne, Cuervo-Lombard, Christine-Vanessa, Peyre, Hugo, Lemogne, Cédric, Limosin, Frédéric, Portefaix, C., Adès, J., Alezrah, C., Amado, I., Amar, G., Andréi, O., Arbault, D., Archambault, G., Aurifeuille, G., Barrière, S., Béra-Potelle, C., Bardou, H., Bareil-Guérin, M., Barrau, P., Barrouillet, C., Baup, E., Bazin, N., Beaufils, B., Ben Ayed, J., Benoit, M., Benyacoub, K., Bichet, T., Blanadet, F., Blanc, O., Blanc-Comiti, J., Boussiron, D., Bouysse, A.M., Brochard, A., Brochart, O., Bucheron, B., Cabot, M., Camus, V., Chabannes, J.M., Charlot, V., Charpeaud, T., Clad-Mor, C., Combes, C., Comisu, M., Cordier, B., Costi, F., Courcelles, J.P., Creixell, M., Cuche, H., Dammak, A., Da Rin, D., Denis, J.B., Denizot, H., Deperthuis, A., Diers, E., Dirami, S., Donneau, D., DREANO, P., Dubertret, C., Duprat, E., Duthoit, D., Fernandez, C., Fonfrede, P., Freitas, N., Gasnier, P., Gauillard, J., Getten, F., Gierski, F., Godart, F., Gourevitch, R., Grassin Delyle, A., Gremion, J., Gres, H., Griner, V., Guerin-Langlois, C., Guggiari, C., Guillin, O., Hadaoui, H., Haffen, E., Hanon, Cécile, Haouzir, S., Hazif-Thomas, C., Heron, A., Hubsch, B., Jalenques, I., Januel, D., Karnycheff, J.F., Kebir, O., Krebs, M.O., Lajugie, C., Leboyer, M., Legrand, P., Lejoyeux, M., Lemaire, V., Leroy, E., Levy-Chavagnat, D., Leydier, A., Liling, C., Llorca, P.M., Loeffel, P., Louville, P., Lucas Navarro, S., Mages, N., Mahi, M., Maillet, O., Manetti, A., Martelli, C., Martin, P., Masson, M., Maurs-Ferrer, I., Mauvieux, J., Mazmanian, S., Mechin, E., Mekaoui, L., Meniai, M., Metton, A., Mihoubi, A., Miron, M., MORA, G., Niro Adès, V., Nubukpo, P., Omnes, C., Papin, S., Paris, P., Passerieux, C., Pellerin, J., Perlbarg, J., Perron, S., Petit, A., Petitjean, F., Pringuey, D., Radtchenko, A., Rahiou, H., Raucher-Chéné, D., Rauzy, A., Reinheimer, L., Renard, M., René, M., Rengade, C.E., Reynaud, P., Robin, D., Rodrigues, C., Rollet, A., Rondepierre, F., Rousselot, B., Rubingher, S., Saba, G., Salvarelli, J.P., Samuelian, J.C., Scemama-Ammar, C., Schurhoff, F., Schuster, J.P., Sechter, D., Segalas, B., Seguret, T., Seigneurie, A.S., Semmak, A., Slama, F., Taisne, S., Taleb, M., Terra, J.L., Thefenne, D., Tran, E., Tourtauchaux, R., Vacheron, M.N., Vandel, P., Vanhoucke, V., Venet, E., Verdoux, H., Viala, A., Vidon, G., Vitre, M., Vurpas, J.L., Wagermez, C., Walter, M., Yon, L., Zendjidjian, X., Rotenberg, Léa, Centre de Recherche en Sciences et Technologies de l'Information et de la Communication - EA 3804 (CRESTIC), Université de Reims Champagne-Ardenne (URCA), Department of Radiology, Maison Blanche Hospital, Université Reims-Champagne-Ardenne, 45, rue Cognacq-Jay, 51092 Reims, France, and Centre Hospitalier Universitaire de Reims (CHU Reims)

Subjects
Male, medicine.medical_specialty, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, Population, Psychological intervention, Schizoaffective disorder, Psychiatric Department, Hospital, Neuropsychological Tests, 03 medical and health sciences, 0302 clinical medicine, Quality of life, [INFO.INFO-TS]Computer Science [cs]/Signal and Image Processing, Brief Psychiatric Rating Scale, medicine, [INFO.INFO-IM]Computer Science [cs]/Medical Imaging, Humans, Pharmacology (medical), Cognitive Dysfunction, education, Psychiatry, Biological Psychiatry, ComputingMilieux_MISCELLANEOUS, Aged, Aged, 80 and over, education.field_of_study, business.industry, General Medicine, Middle Aged, medicine.disease, 030227 psychiatry, Psychiatry and Mental health, Schizophrenia, Cohort, Disease Progression, Quality of Life, Female, France, business, 030217 neurology & neurosurgery, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, Psychopathology, Follow-Up Studies
Abstract

The severity of psychopathology has a strong negative impact on quality of life (QoL) among older adults with schizophrenia spectrum disorder. However, because these subjects generally experience multiple psychiatric symptoms, it remains unclear whether decreased QoL in this population is due to specific symptoms (e.g., hallucinations), specific dimensions of psychopathology (e.g., negative symptoms), a general psychopathology dimension representing the shared effect across all psychiatric symptoms, or a combination of these explanations. Data were derived from the Cohort of individuals with Schizophrenia Aged 55 years or more (CSA) study, a large (N = 353) multicenter sample of older adults with schizophrenia spectrum disorder recruited from French public-sector psychiatric departments. We used structural equation modeling to examine the shared and specific effects of psychiatric symptoms on QoL, while adjusting for sociodemographic characteristics, general medical conditions, global cognitive functioning and psychotropic medications. Psychiatric symptoms and QoL were assessed face-to-face by psychiatrists using the Brief Psychiatric Rating Scale (BPRS) and the Quality of Life Scale (QLS). Among older adults with schizophrenia spectrum disorder, effects of psychiatric symptoms on QoL were exerted mostly through a general psychopathology dimension (β = − 0.43, p

Published
2018
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19. Psychiatric and physical outcomes of long-term use of lithium in older adults with bipolar disorder and major depressive disorder: A cross-sectional multicenter study

Author

Morlet, Elise, primary, Costemale-Lacoste, Jean-François, additional, Poulet, Emmanuel, additional, McMahon, Kibby, additional, Hoertel, Nicolas, additional, Limosin, Frédéric, additional, Adès, J, additional, Alezrah, C, additional, Amado, I, additional, Amar, G, additional, Andréi, O, additional, Arbault, D, additional, Archambault, G, additional, Aurifeuille, G, additional, Barrière, S, additional, Béra-Potelle, C, additional, Blumenstock, Y, additional, Bardou, H, additional, Bareil-Guérin, M, additional, Barrau, P, additional, Barrouillet, C, additional, Baup, E, additional, Bazin, N, additional, Beaufils, B, additional, Ben Ayed, J, additional, Benoit, M, additional, Benyacoub, K, additional, Bichet, T, additional, Blanadet, F, additional, Blanc, O, additional, Blanc-Comiti, J, additional, Boussiron, D, additional, Bouysse, AM, additional, Brochard, A, additional, Brochart, O, additional, Bucheron, B, additional, Cabot, M, additional, Camus, V, additional, Chabannes, JM, additional, Charlot, V, additional, Charpeaud, T, additional, Clad-Mor, C, additional, Combes, C, additional, Comisu, M, additional, Cordier, B, additional, Costi, F, additional, Courcelles, JP, additional, Creixell, M, additional, Cuche, H, additional, Cuervo-Lombard, C, additional, Dammak, A, additional, Da Rin, D, additional, Denis, JB, additional, Denizot, H, additional, Deperthuis, A, additional, Diers, E, additional, Dirami, S, additional, Donneau, D, additional, Dreano, P, additional, Dubertret, C, additional, Duprat, E, additional, Duthoit, D, additional, Fernandez, C, additional, Fonfrede, P, additional, Freitas, N, additional, Gasnier, P, additional, Gauillard, J, additional, Getten, F, additional, Gierski, F, additional, Godart, F, additional, Gourevitch, R, additional, Grassin Delyle, A, additional, Gremion, J, additional, Gres, H, additional, Griner, V, additional, Guerin-Langlois, C, additional, Guggiari, C, additional, Guillin, O, additional, Hadaoui, H, additional, Haffen, E, additional, Hanon, C, additional, Haouzir, S, additional, Hazif-Thomas, C, additional, Heron, A, additional, Hubsch, B, additional, Jalenques, I, additional, Januel, D, additional, Kaladjian, A, additional, Karnycheff, JF, additional, Kebir, O, additional, Krebs, MO, additional, Lajugie, C, additional, Leboyer, M, additional, Legrand, P, additional, Lejoyeux, M, additional, Lemaire, V, additional, Leroy, E, additional, Levy-Chavagnat, D, additional, Leydier, A, additional, Liling, C, additional, Llorca, PM, additional, Loeffel, P, additional, Louville, P, additional, Lucas Navarro, S, additional, Mages, N, additional, Mahi, M, additional, Maillet, O, additional, Manetti, A, additional, Martelli, C, additional, Martin, P, additional, Masson, M, additional, Maurs-Ferrer, I, additional, Mauvieux, J, additional, Mazmanian, S, additional, Mechin, E, additional, Mekaoui, L, additional, Meniai, M, additional, Metton, A, additional, Mihoubi, A, additional, Miron, M, additional, Mora, G, additional, Niro Adès, V, additional, Nubukpo, P, additional, Omnes, C, additional, Papin, S, additional, Paris, P, additional, Passerieux, C, additional, Pellerin, J, additional, Perlbarg, J, additional, Perron, S, additional, Petit, A, additional, Petitjean, F, additional, Portefaix, C, additional, Pringuey, D, additional, Radtchenko, A, additional, Rahiou, H, additional, Raucher-Chéné, D, additional, Rauzy, A, additional, Reinheimer, L, additional, Renard, M, additional, René, M, additional, Rengade, CE, additional, Reynaud, P, additional, Robin, D, additional, Rodrigues, C, additional, Rollet, A, additional, Rondepierre, F, additional, Rousselot, B, additional, Rubingher, S, additional, Saba, G, additional, Salvarelli, JP, additional, Samuelian, JC, additional, Scemama-Ammar, C, additional, Schurhoff, F, additional, Schuster, JP, additional, Sechter, D, additional, Segalas, B, additional, Seguret, T, additional, Seigneurie, AS, additional, Semmak, A, additional, Slama, F, additional, Taisne, S, additional, Taleb, M, additional, Terra, JL, additional, Thefenne, D, additional, Tran, E, additional, Tourtauchaux, R, additional, Vacheron, MN, additional, Vandel, P, additional, Vanhoucke, V, additional, Venet, E, additional, Verdoux, H, additional, Viala, A, additional, Vidon, G, additional, Vitre, M, additional, Vurpas, JL, additional, Wagermez, C, additional, Walter, M, additional, Yon, L, additional, and Zendjidjian, X., additional

Published
2019
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20. Effects of depression and cognitive impairment on quality of life in older adults with schizophrenia spectrum disorder: Results from a multicenter study

Author

Pascal de Raykeer, Rachel, primary, Hoertel, Nicolas, additional, Blanco, Carlos, additional, Lavaud, Pierre, additional, Kaladjian, Arthur, additional, Blumenstock, Yvonne, additional, Cuervo-Lombard, Christine-Vanessa, additional, Peyre, Hugo, additional, Lemogne, Cédric, additional, Limosin, Frédéric, additional, Adès, J., additional, Alezrah, C., additional, Amado, I., additional, Amar, G., additional, Andréi, O., additional, Arbault, D., additional, Archambault, G., additional, Aurifeuille, G., additional, Barrière, S., additional, Béra-Potelle, C., additional, Blumenstock, Y., additional, Bardou, H., additional, Bareil-Guérin, M., additional, Barrau, P., additional, Barrouillet, C., additional, Baup, E., additional, Bazin, N., additional, Beaufils, B., additional, Ben Ayed, J., additional, Benoit, M., additional, Benyacoub, K., additional, Bichet, T., additional, Blanadet, F., additional, Blanc, O., additional, Blanc-Comiti, J., additional, Boussiron, D., additional, Bouysse, A.M., additional, Brochard, A., additional, Brochart, O., additional, Bucheron, B., additional, Cabot, M., additional, Camus, V., additional, Chabannes, J.M., additional, Charlot, V., additional, Charpeaud, T., additional, Clad-Mor, C., additional, Combes, C., additional, Comisu, M., additional, Cordier, B., additional, Costi, F., additional, Courcelles, J.P., additional, Creixell, M., additional, Cuche, H., additional, Cuervo-Lombard, C., additional, Dammak, A., additional, Da Rin, D., additional, Denis, J.B., additional, Denizot, H., additional, Deperthuis, A., additional, Diers, E., additional, Dirami, S., additional, Donneau, D., additional, Dreano, P., additional, Dubertret, C., additional, Duprat, E., additional, Duthoit, D., additional, Fernandez, C., additional, Fonfrede, P., additional, Freitas, N., additional, Gasnier, P., additional, Gauillard, J., additional, Getten, F., additional, Gierski, F., additional, Godart, F., additional, Gourevitch, R., additional, Grassin Delyle, A., additional, Gremion, J., additional, Gres, H., additional, Griner, V., additional, Guerin-Langlois, C., additional, Guggiari, C., additional, Guillin, O., additional, Hadaoui, H., additional, Haffen, E., additional, Hanon, C., additional, Haouzir, S., additional, Hazif-Thomas, C., additional, Heron, A., additional, Hoertel, N., additional, Hubsch, B., additional, Jalenques, I., additional, Januel, D., additional, Kaladjian, A., additional, Karnycheff, J.F., additional, Kebir, O., additional, Krebs, M.O., additional, Lajugie, C., additional, Leboyer, M., additional, Legrand, P., additional, Lejoyeux, M., additional, Lemaire, V., additional, Leroy, E., additional, Levy-Chavagnat, D., additional, Leydier, A., additional, Liling, C., additional, Limosin, F., additional, Llorca, P.M., additional, Loeffel, P., additional, Louville, P., additional, Lucas Navarro, S., additional, Mages, N., additional, Mahi, M., additional, Maillet, O., additional, Manetti, A., additional, Martelli, C., additional, Martin, P., additional, Masson, M., additional, Maurs-Ferrer, I., additional, Mauvieux, J., additional, Mazmanian, S., additional, Mechin, E., additional, Mekaoui, L., additional, Meniai, M., additional, Metton, A., additional, Mihoubi, A., additional, Miron, M., additional, Mora, G., additional, Niro Adès, V., additional, Nubukpo, P., additional, Omnes, C., additional, Papin, S., additional, Paris, P., additional, Passerieux, C., additional, Pellerin, J., additional, Perlbarg, J., additional, Perron, S., additional, Petit, A., additional, Petitjean, F., additional, Portefaix, C., additional, Pringuey, D., additional, Radtchenko, A., additional, Rahiou, H., additional, Raucher-Chéné, D., additional, Rauzy, A., additional, Reinheimer, L., additional, Renard, M., additional, René, M., additional, Rengade, C.E., additional, Reynaud, P., additional, Robin, D., additional, Rodrigues, C., additional, Rollet, A., additional, Rondepierre, F., additional, Rousselot, B., additional, Rubingher, S., additional, Saba, G., additional, Salvarelli, J.P., additional, Samuelian, J.C., additional, Scemama-Ammar, C., additional, Schurhoff, F., additional, Schuster, J.P., additional, Sechter, D., additional, Segalas, B., additional, Seguret, T., additional, Seigneurie, A.S., additional, Semmak, A., additional, Slama, F., additional, Taisne, S., additional, Taleb, M., additional, Terra, J.L., additional, Thefenne, D., additional, Tran, E., additional, Tourtauchaux, R., additional, Vacheron, M.N., additional, Vandel, P., additional, Vanhoucke, V., additional, Venet, E., additional, Verdoux, H., additional, Viala, A., additional, Vidon, G., additional, Vitre, M., additional, Vurpas, J.L., additional, Wagermez, C., additional, Walter, M., additional, Yon, L., additional, and Zendjidjian, X., additional

Published
2019
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21. Prescription et surveillance d’antipsychotiques chez les patients âgés souffrant de schizophrénie : pratiques des psychiatres et leurs déterminants

Author

Jalenques, I., Auclair, C., Rondepierre, F., Gerbaud, L., Tourtauchaux, R., Ortega, V., Legrand, G., Neuro-Psycho Pharmacologie des Systèmes Dopimanégiques sous-corticaux (NPsy-Sydo), CHU Clermont-Ferrand-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Service d'Epidémiologie, CHU Clermont-Ferrand, Image Science for Interventional Techniques (ISIT), and Université d'Auvergne - Clermont-Ferrand I (UdA)-Clermont Université-Centre National de la Recherche Scientifique (CNRS)

Subjects
Gynecology, medicine.medical_specialty, [SDV.NEU.PC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior, business.industry, [SCCO.NEUR]Cognitive science/Neuroscience, [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, [SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences, Professional practice, 3. Good health, 030227 psychiatry, 03 medical and health sciences, Psychiatry and Mental health, 0302 clinical medicine, Arts and Humanities (miscellaneous), medicine, business, 030217 neurology & neurosurgery, ComputingMilieux_MISCELLANEOUS
Abstract

Resume Objectif Evaluer les pratiques de prescription et de surveillance d’antipsychotiques (AP) en psychiatrie generale chez les patients schizophrenes âges et les facteurs susceptibles d’influer sur elles. Methode Ont ete contactes par courrier 190 psychiatres pour participer a une etude observationnelle de leurs pratiques de prescription d’AP chez des patients schizophrenes de 65 ans et plus. Resultats Le taux de reponse est de 44,2 % ; 75 % des psychiatres ayant repondu traitent des schizophrenes âges. Ils utilisent a 87,7 % un AP de seconde generation en premiere ligne ; 64,9 % prescrivent en monotherapie ; 54,4 % utilisent des AP a action prolongee. La tolerance constitue le critere de choix principal de l’AP pour 3,5 % et secondaire pour 29,8 % des psychiatres. Les surveillances du perimetre abdominal, de la prolactinemie, cardiologique avec electrocardiogramme et ophtalmologique ne sont qu’en partie conformes aux recommandations professionnelles. Lors de la surveillance au long cours, les psychiatres ayant une utilisation courante des recommandations de prise en charge mesurent significativement plus souvent le pouls et la tension arterielle (74,3 % vs 41,2 %, p = 0,03) ainsi que le perimetre abdominal (22,9 % vs 0 %, p = 0,04) compares aux psychiatres qui n’utilisent pas couramment des recommandations de prise en charge. Conclusions Cette etude demontrant un respect inegal en psychiatrie generale des recommandations de prise en charge concernant la prescription et la surveillance des AP chez les patients schizophrenes âges, precise les pratiques a ameliorer : choix de l’AP d’abord en fonction de la tolerance, surveillances du perimetre abdominal, de la prolactinemie, cardiologique avec electrocardiogramme et ophtalmologique.

Published
2016
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23. Plasma levels of 8-epiPGF2alpha, an in vivo marker of oxidative stress, are not affected by aging or Alzheimer's disease

Author

Feillet Coudray, C., Tourtauchaux, R., Niculescu, M., Edmond Rock, Tauveron, I., Marie-Cécile Alexandre-Gouabau, Yves Rayssiguier, Jalenques, I., André Mazur, Unité de recherche Maladies Métaboliques et Micronutriments (U3M), and Institut National de la Recherche Agronomique (INRA)

Subjects
[SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
1999

27. 8 Étude de faisabilité en vue de la validation de la version française de l’échelle LEIPAD : échelle de qualité de vie des sujets âgés de 65 ans et plus vivant à domicile

Author

Roblin, J., primary, Auclair, C., additional, Vaille-Perret, E., additional, Tourtauchaux, R., additional, Watts, J., additional, Malet, L., additional, Ledieu, P., additional, Ristori, J.-M., additional, Tauveron, I., additional, Gerbaud, L., additional, De Leo, D., additional, and Jalenques, I., additional

Published
2008
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31. Le suicide du sujet âgé

Author

Lebret, S., primary, Vaille-Perret, E., additional, Vinot, J., additional, Brousse, G., additional, Galland, F., additional, Tourtauchaux, R., additional, and Jalenques, I., additional

Published
2003
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35. [Health-related quality of life evaluation of elderly aged 65 years and over living at home].

Author

Jalenques I, Auclair C, Rondepierre F, Gerbaud L, and Tourtauchaux R

Subjects
Aged, Aged, 80 and over, Female, Humans, Language, Male, Residence Characteristics, Surveys and Questionnaires, Quality of Life
Abstract

Background: To assess health-related quality of life in French adults aged 65 years and over, living at home, with a specific self-administered questionnaire, the LEIPAD, cross-culturally adapted in French., Methods: Elderly completed socio-demographic and medical questionnaires, a questionnaire about negative life events during the last 12 months and the LEIPAD., Results: Data of 195 subjects (mean age: 72.6 years, men: 56.5%) were analyzed. The response rates to the LEIPAD scales were superior to 90%. Elderly reported on the whole a good health-related quality of life. Age had a negative effect on quality on life, which deteriorates over years. Age was correlated to the scales "Physical function", "Self-care", "Cognitive functioning" and "Sexual functioning". Elderly hospitalized in the last year had worse quality of life with a significant difference for "Physical function" scale. The number of health problems was positively correlated to "Physical function" scale. Elderly declaring at least one health problem had worse quality of life for this scale. Problems in couple, materials and financial problems had also negative effects on health-related quality of life., Conclusion: Our study highlights a good health-related quality of life for the majority of these adults aged 65 years and over, as well as the negative effect of age, health, couple, materials and financial problems on their quality of life., (Copyright © 2015 Elsevier Masson SAS. All rights reserved.)

Published
2015
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36. [Old patients suffering from long-standing schizophrenia: clinical aspects].

Author

Jalenques I, Rachez C, Tourtauchaux R, Cellier Y, and Legrand G

Subjects
Aged, Aging psychology, Antipsychotic Agents adverse effects, Cognition Disorders etiology, Cognition Disorders psychology, Humans, Persons with Intellectual Disabilities, Social Behavior, Antipsychotic Agents therapeutic use, Schizophrenia drug therapy, Schizophrenic Psychology
Abstract

Although some patients suffering from schizophrenia experience an age-related amelioration, a great number of people who are entering old age suffer from long-standing schizophrenia. These patients show specific psychiatric and somatic problems that must be taken into account. Firstly, some display high levels of all schizophrenic symptoms, while others experience changes in the symptom profile with aging, i.e. a reduction in positive symptoms and an increase in negative ones. Secondly, the occurrence of significant depressive symptoms among elderly patients with schizophrenia is well recognized. Thirdly, in recent years, studies have begun to shed more light on the trajectories of cognitive impairment of these patients in old age. Lastly, aged persons with schizophrenia often have side effects due to long-term antipsychotic medications and medical co-morbidity, more untreated somatic disorders (diabetes, cardiovascular diseases) and higher mortality rates. These may be the result of both lifestyle factors and lack of adequate medical care. Levels of adaptive functioning and quality of life are closely associated with clinical and social factors. Thus, we must consider all these different aspects in order to effectively manage the therapeutic and service needs of these patients.

Published
2011
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37. Plasma levels of 8-epiPGF2alpha, an in vivo marker of oxidative stress, are not affected by aging or Alzheimer's disease.

Author

Feillet-Coudray C, Tourtauchaux R, Niculescu M, Rock E, Tauveron I, Alexandre-Gouabau MC, Rayssiguier Y, Jalenques I, and Mazur A

Subjects
Adult, Aged, Aged, 80 and over, Biomarkers blood, Dinoprost blood, Female, Free Radicals, Humans, Linear Models, Lipid Peroxidation physiology, Male, Middle Aged, Nutritional Status, Aging blood, Alzheimer Disease blood, Dinoprost analogs & derivatives, Oxidative Stress physiology
Abstract

Free radicals are likely involved in the aging process and there is a growing body of evidence that free radical damage to cellular function is associated with a number of age-related diseases such as atherosclerosis, cancer, and neurologic disorders. The present study was designed to evaluate in a healthy population the evolution with age of 8-epiPGF2alpha plasma levels, a recently proposed marker of in vivo lipid peroxidation. Moreover we investigated this marker of oxidative stress in patients with Alzheimer's disease (AD), an age-related neurodegenerative disorder in the development of which free radicals have been involved. Our results show that in the healthy population studied, despite decreased antioxidant defenses with increasing age as monitored by antioxidant capacity measurement, plasma 8-epiPGF2alpha levels were not correlated with age. Moreover, we have demonstrated that AD patients presented no modification of plasma 8-epiPGF2alpha level and no major alteration of the antioxidant status. In conclusion, the measurement of plasma 8-epiPGF2alpha did not allow us to detect alterations in oxidative stress with aging or in AD.

Published
1999
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