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5. Smart Mat for Respiratory Activity Detection: Study in a Clinical Setting

Author

Otis, Samuel, Abdulrazak, Bessam, Jebara, Sofia Ben, Tournoux, Francois, Mezghani, Neila, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Woeginger, Gerhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Pagán, José, editor, Mokhtari, Mounir, editor, Aloulou, Hamdi, editor, Abdulrazak, Bessam, editor, and Cabrera, María Fernanda, editor

Published
2019
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7. Barriers to telemedicine for patients with heart failure: Who are the patients being left behind?

Author

Zuchinali, Priccila, Béchard, Stéphanie, Remillard, Emilie, Souza Grigoletti, Shana, Marier-Tétrault, Emmanuel, Jean-Charles, Loyda, Ribeiro, Paula AB, and Tournoux, François

Subjects
HEART failure patients, TELEMEDICINE, SMART devices, HEART failure, SOCIOECONOMIC factors
Abstract

Heart failure is associated with high rates of hospitalization, which are more prevalent in frail patients, impacting the quality of life and clinical outcomes. Telemedicine is considered cost-effective for improving patient self-management and hospitalization. However, socioeconomic deprivation and frailty could hinder access to virtual care. We investigated if frailty and socioeconomic factors were associated with telemedicine access among heart failure patients. For this cross-sectional analysis of Continuum study, 35 patients were allocated to the "able to use" group (had a smart device and were able to use it) or the "not able to use" group. Socioeconomic deprivation was determined according to the deprivation index. Frailty was assessed using the Fried criteria. The mean age was 69.9 ± 9 years, 74% were in New York Heart Association class II. A total of 14 patients (39%) were physically frail. Patients considered not able to use the app were more socioeconomically deprived (p = 0.011) and frail (p = 0.036). There was no correlation between frailty score and socioeconomic deprivation (r = 0.15, p = 0.411). Telemedicine use seems to be independently associated with frailty and socioeconomic deprivation in heart failure patients. More efforts should be made to foster the inclusion of vulnerable patients and improve global telemedicine access. [ABSTRACT FROM AUTHOR]

Published
2024
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11. [18F]Fluoropyridine‐losartan: A new approach toward human Positron Emission Tomography imaging of Angiotensin II Type 1 receptors

Author

Abreu Diaz, Aida Mary, primary, Rodriguez Riera, Zalua, additional, Lee, Yanick, additional, Esteves, Luis Miguel, additional, Normandeau, Charles‐Olivier, additional, Fezas, Baptiste, additional, Hernandez Saiz, Alejandro, additional, Tournoux, François, additional, Juneau, Daniel, additional, and DaSilva, Jean N., additional

Published
2023
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12. Remote patient monitoring and digital therapeutics in heart failure: lessons from the Continuum pilot study

Author

Marier-Tétrault, Emmanuel, primary, Bebawi, Emmanuel, additional, Béchard, Stéphanie, additional, Brouillard, Philippe, additional, Zuchinali, Priccila, additional, Remillard, Emilie, additional, Carrier, Zoé, additional, Jean-Charles, Loyda, additional, Nguyen, John, additional, Lehoux, Pascale, additional, Pomey, Marie-Pascale, additional, Ribeiro, Paula A. B., additional, and Tournoux, François, additional

Published
2022
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14. The prognostic significance of atrial fibrillation in heart failure with preserved ejection function: insights from KaRen, a prospective and multicenter study

Author

Bosseau, Christian, Donal, Erwan, Lund, Lars H., Oger, Emmanuel, Hage, Camilla, Mulak, Geneviève, Daubert, Jean-Claude, Linde, Cecilia, Donal, Erwan, Lund, Lars H., Leclercq, Christophe, de Groote, Pascal, Ennezat, Pierre-Vladimir, Lafitte, Stéphane, Réant, Patricia, Bauer, Fabrice, Derumeaux, Geneviève, Bergerot, Cyrille, de Place, Christian, Juillière, Yves, Selton-Suty, Christine, Logeart, Damien, Gueret, Pascal, Lim, Pascal, Trochu, Jean-Noël, Pirou, Nicolas, Habib, Gilbert, Tournoux, François, Haugen-Löfman, Ida, Edner, Magnus, Emtell, Hans, and On behalf of the KaRen investigators

Published
2017
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15. Association Between Right Ventricular Dysfunction and Adverse Outcomes in Peripartum Cardiomyopathy: Insights From the BRO-HF Quebec Cohort Study

Author

Pacheco, Christine, primary, Tremblay-Gravel, Maxime, additional, Marquis-Gravel, Guillaume, additional, Couture, Etienne, additional, Avram, Robert, additional, Desplantie, Olivier, additional, Bibas, Lior, additional, Simard, François, additional, Malhamé, Isabelle, additional, Poulin, Anthony, additional, Tran, Dan, additional, Senechal, Mario, additional, Afilalo, Jonathan, additional, Farand, Paul, additional, Bérubé, Lyne, additional, Jolicoeur, E. Marc, additional, Ducharme, Anique, additional, and Tournoux, François, additional

Published
2022
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18. Developing practice guidelines to integrate physical activity promotion as part of routine cancer care: A knowledge-to-action protocol

Author

Doré, Isabelle, primary, Plante, Audrey, additional, Bedrossian, Nathalie, additional, Montminy, Sarah, additional, St-Onge, Kadia, additional, St-Cyr, Jany, additional, Pomey, Marie-Pascale, additional, Charpentier, Danielle, additional, Pettigrew, Lise, additional, Brisson, Isabelle, additional, Saad, Fred, additional, Tournoux, François, additional, Raynault, Marie-France, additional, Mes-Masson, Anne-Marie, additional, and Gauvin, Lise, additional

Published
2022
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20. [18F]Fluoropyridine‐losartan: A new approach toward human Positron Emission Tomography imaging of Angiotensin II Type 1 receptors.

Author

Abreu Diaz, Aida Mary, Rodriguez Riera, Zalua, Lee, Yanick, Esteves, Luis Miguel, Normandeau, Charles‐Olivier, Fezas, Baptiste, Hernandez Saiz, Alejandro, Tournoux, François, Juneau, Daniel, and DaSilva, Jean N.

Subjects
POSITRON emission tomography, ANGIOTENSIN II, COPPER, QUALITY control, RADIOLYSIS, LOSARTAN, CLICK chemistry
Abstract

Angiotensin II type 1 receptors (AT1R) blocker losartan is used in patients with renal and cardiovascular diseases. [18F]fluoropyridine‐losartan has shown favorable binding profile for quantitative renal PET imaging of AT1R with selective binding in rats and pigs, low interference of radiometabolites and appropriate dosimetry for clinical translation. A new approach was developed to produce [18F]fluoropyridine‐losartan in very high molar activity. Automated radiosynthesis was performed in a three‐step, two‐pot, and two‐HPLC‐purification procedure within 2 h. Pure [18F]FPyKYNE was obtained by radiofluorination of NO2PyKYNE and silica‐gel‐HPLC purification (40 ± 9%), preventing the formation of nitropyridine‐losartan in the second step. Conjugation with trityl‐losartan azide via click chemistry, followed by acid hydrolysis, C18‐HPLC purification and reformulation provided [18F]fluoropyridine‐losartan in 11 ± 2% (decay‐corrected from [18F]fluoride, EOB). Using tris[(1‐(3‐hydroxypropyl)‐1H‐1,2,3‐triazol‐4‐yl)methyl]‐amine (THPTA) as a Cu(I)‐stabilizing agent for coupling [18F]FPyKYNE to the unprotected losartan azide afforded [18F]fluoropyridine‐losartan in similar yields (11 ± 3%, decay‐corrected from [18F]fluoride, EOB). Reverse‐phase HPLC was optimized by reducing the pH of the mobile phase to achieve complete purification and high molar activities (467 ± 60 GBq/μmol). The use of radioprotectants prevented tracer radiolysis for 10 h (RCP > 99%). The product passed the quality control testing. This reproducible automated radiosynthesis process will allow in vivo PET imaging of AT1R expression in several diseases. [ABSTRACT FROM AUTHOR]

Published
2023
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24. Monkeypox associated myocarditis: A case report

Author

Brouillard, Philippe, primary, Valin-Thorburn, Anthony, additional, Provost, Yves, additional, Chakravarti, Arpita, additional, Honos, George, additional, Tournoux, François, additional, and Tremblay, Cécile, additional

Published
2022
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31. The effect of bromocriptine on left ventricular functional recovery in peripartum cardiomyopathy: insights from the BRO‐HF retrospective cohort study

Author

Tremblay‐Gravel, Maxime, Marquis‐Gravel, Guillaume, Avram, Robert, Desplantie, Olivier, Ducharme, Anique, Bibas, Lior, Pacheco, Christine, Couture, Etienne, Simard, François, Poulin, Anthony, Malhamé, Isabelle, Tran, Dan, Rey, Evelyne, Tournoux, François, Harvey, Luc, Sénéchal, Mario, Bélisle, Pierre, Descarries, Laurence, Farand, Paul, Pranno, Nicolas, Diaz, Ariel, Afilalo, Jonathan, Ly, Hung Q., Fortier, Annik, and Jolicoeur, Etienne Marc

Subjects
Adult, Peripartum cardiomyopathy, Heart Ventricles, Pregnancy Complications, Cardiovascular, Heart failure, Stroke Volume, Recovery of Function, Ventricular Function, Left, Treatment Outcome, Pregnancy, Echocardiography, Original Research Articles, Dopamine Agonists, Peripartum Period, Humans, Female, Original Research Article, Cardiomyopathies, Bromocriptine, Follow-Up Studies, Retrospective Studies
Abstract

Aims Bromocriptine is thought to facilitate left ventricular (LV) recovery in peripartum cardiomyopathy (PPCM) through inhibition of prolactin secretion. However, this potential therapeutic effect remains controversial and was incompletely studied in diverse populations. Methods and results Consecutive women with new‐onset PPCM (n = 76) between 1994 and 2015 in Quebec, Canada, were classified according to treatment (n = 8, 11%) vs. no treatment (n = 68, 89%) with bromocriptine. We assessed LV functional recovery at mid‐term (6 months) and long‐term (last follow‐up) and compared outcomes among groups. Women treated with bromocriptine experienced better mid‐term left ventricular ejection fraction (LVEF) recovery from 23 ± 10% at baseline to 55 ± 12% at 6 months, compared with a change from 30 ± 12% at baseline to 45 ± 13% at 6 months in women treated with standard medical therapy (P interaction

Published
2018

32. Aortic stenosis and cardiac amyloidosis : JACC review topic of the week

Author

Magne, Julien, Krapf, Laura, Mohty, Dania, Côté, Nancy, Pibarot, Philippe, Nguyen, Annabelle, Clavel, Marie-Annick, Galat, Arnault, Ternacle, Julien, Gallet, Romain, Teiger, Emmanuel, Tournoux, François, Damy, Thibaud, Magne, Julien, Krapf, Laura, Mohty, Dania, Côté, Nancy, Pibarot, Philippe, Nguyen, Annabelle, Clavel, Marie-Annick, Galat, Arnault, Ternacle, Julien, Gallet, Romain, Teiger, Emmanuel, Tournoux, François, and Damy, Thibaud

Abstract

The prevalence of calcific aortic stenosis (AS) and of cardiac amyloidosis (CA) increases with age, and their association is not uncommon in the elderly. The identification of CA is particularly challenging in patients with AS because these 2 conditions share several features. It is estimated that #15% of the AS population and #30% of the subset with low-flow, low-gradient pattern may have CA. In patients with AS, CA is associated with increased risk of heart failure, mortality, and treatment futility with aortic valve replacement. In case of suspicion of CA, it is thus crucial to confirm the diagnosis to guide therapeutic management of AS and eventually implement recently developed pharmacological treatment dedicated to transthyretin amyloidosis. Given the high surgical risk of patients with AS and concomitant CA, transcatheter aortic valve replacement may be preferred to surgery in these patients.

Published
2020

36. Electrocardiographic changes after completion of a triathlon

Author

Hosatte‐Ducassy, Caroline, primary, Correa, José A., additional, Lalonde, François, additional, Mohindra, Rohit, additional, Marton, Gregory, additional, Chetrit, Michael, additional, Marcotte, Audrey, additional, Tournoux, François, additional, and Bridges, Eileen, additional

Published
2020
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42. Aortic Stenosis and Cardiac Amyloidosis

Author

Ternacle, Julien, Krapf, Laura, Mohty, Dania, Magne, Julien, Nguyen, Annabelle, Galat, Arnault, Gallet, Romain, Teiger, Emmanuel, Côté, Nancy, Clavel, Marie-Annick, Tournoux, François, Pibarot, Philippe, Damy, Thibaud, and Clinical sciences

Abstract

The prevalence of calcific aortic stenosis (AS) and of cardiac amyloidosis (CA) increases with age, and their association is not uncommon in the elderly. The identification of CA is particularly challenging in patients with AS because these 2 conditions share several features. It is estimated that ≤15% of the AS population and ≤30% of the subset with low-flow, low-gradient pattern may have CA. In patients with AS, CA is associated with increased risk of heart failure, mortality, and treatment futility with aortic valve replacement. In case of suspicion of CA, it is thus crucial to confirm the diagnosis to guide therapeutic management of AS and eventually implement recently developed pharmacological treatment dedicated to transthyretin amyloidosis. Given the high surgical risk of patients with AS and concomitant CA, transcatheter aortic valve replacement may be preferred to surgery in these patients.

Published
2019

45. Smart Mat for Respiratory Activity Detection: Study in a Clinical Setting

Author

Pagán, J., Mokhtari, M., Aloulou, H., Abdulrazak, B., Cabrera, M., Otis, Samuel, Bessam, Abdulrazak, Ben Jebara, Sofia, Tournoux, François, Mezghani, Neila, Pagán, J., Mokhtari, M., Aloulou, H., Abdulrazak, B., Cabrera, M., Otis, Samuel, Bessam, Abdulrazak, Ben Jebara, Sofia, Tournoux, François, and Mezghani, Neila

Abstract

We discuss in this paper a study of a smart and unobtrusive mattress in a clinical setting on a population with cardiorespiratory problems. Up to recently, the vast majority of studies with unobtrusive sensors are done with healthy populations. The unobtrusive monitoring of the Respiratory Rate (RR) is essential for proposing better diagnoses. Thus, new industrial and research activity on smart mattresses is targeting respiratory rate in an Internet-of-Things (IoT) context. In our work, we are interested in the performances of a microbend fiber optic sensor (FOS) mattress on 81 subjects admitted in the Cardiac Intensive Care Unit (CICU) by estimating the RR from their ballistocardiograms (BCG). Our study proposes a new RR estimator, based on harmonic plus noise models (HNM) and compares it with known estimators such as MODWT and CLIE. The goal is to examine, using a more representative and bigger dataset, the performances of these methods and of the smart mattress in general. Results of applying these three estimators on the BCG show that MODWT is more accurate with an average mean absolute error (MAE) of 1.97 ± 2.12 BPM. However, the HNM estimator has space for improvements with estimation errors of 2.91 ± 4.07 BPM. The smart mattress works well within a standard RR range of 10–20 breaths-per-minute (BPM) but gets less accurate with a bigger range of estimation. These results highlight the need to test these sensors in much more realistic contexts.

Published
2019

46. Accuracy of speckle tracking in the context of stress echocardiography in short axis view: An in vitro validation study

Author

Hodzic, Amir, Chayer, Boris, Wang, Diya, Porée, Jonathan, Cloutier, Guy, Milliez, Paul, Normand, Hervé, Garcia, Damien, Saloux, Eric, Tournoux, François, Erdoes, Gabor, Centre Hospitalier de l'Université de Montréal (CHUM), Université de Montréal (UdeM), Laboratory of Biorheology and Medical Ultrasonics (LBUM), Université de Montréal (UdeM)-Hospital Research Center, Centre de Recherche Cardiovasculaire de Lariboisiere, Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Cognition, Mobilités, Temporalité (COMETE), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Imagerie Ultrasonore, Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de cardiologie et de pathologie vasculaire [CHU Caen], Normandie Université (NU)-Normandie Université (NU)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN), Biomarqueurs CArdioNeuroVASCulaires (BioCANVAS), and Université Paris 13 (UP13)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
[PHYS.PHYS.PHYS-FLU-DYN]Physics [physics]/Physics [physics]/Fluid Dynamics [physics.flu-dyn], [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, [INFO.INFO-TS]Computer Science [cs]/Signal and Image Processing, [INFO.INFO-IM]Computer Science [cs]/Medical Imaging, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2018

47. Electrocardiographic Changes After Completion of a Triathlon

Author

Hosatte-Ducassy, Caroline, primary, Correa, José A., additional, Lalonde, François, additional, Mohindra, Rohit, additional, Marton, Gregory, additional, Chetrit, Michael, additional, Marcotte, Audrey, additional, Tournoux, François, additional, and Bridges, Eileen, additional

Published
2019
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49. Remote Ischemic Preconditioning Does Not Improve the Six Minutes Walk Test Performance in Chronic Heart Failure Patients: a Randomised Pilot Trial.

Author

MARTIN, SARAH-MAUDE, LALONDE, FRANÇOIS, LEGAULT, ÉLISE, RIBEIRO, PAULA, COMTOIS, ALAIN STEVE, and TOURNOUX, FRANÇOIS

Subjects
ISCHEMIC preconditioning, HEART failure patients, RANDOMIZED controlled trials, WALKING, OXYGEN saturation
Abstract

Cycles of ischemia and reperfusion induced with a pressure cuff on a skeletal muscle, also know as remote ischemic preconditioning (RIPC), appears to improve performance in different time-trial events in healthy individuals. Our primary goal was to assess the effect of RIPC in heart failure (HF) patients' functional capacity using the six-minute walk test (6MWT). A randomized crossover design comparing RIPC (4 x five-minutes of upper arm ischemia) to the SHAM procedure was done in 15 patients prior to a 6MWT. The primary outcome measure was the total distance walked in a standardized 6MWT (20m corridor). Metabolic and hemodynamic responses were measured using gas exchange analysis with a portable metabolic analyzer and peripheral skeletal muscle oxygen saturation (smO2) with near-infrared spectroscopy. The total distance travelled during 6MWT was not significantly different between the RIPC (347 ± 63 m) and the SHAM procedure (352 ± 65 m; p = 0.514). Relative oxygen uptake did not change when comparing interventions: 10.26 ± 2.01 ml/kg/min vs 10.69 ± 2.51 ml/kg/min (RIPC vs SHAM, respectively, p = 0.278). As well, no significant differences were observed for heart rate, respiratory exchange ratio, smO2, and ventilation. Even though HF patients tolerated well the RIPC intervention, it did not provide any significant improvement in functional capacity and other physiological parameters in our sample of patients. [ABSTRACT FROM AUTHOR]

Published
2021
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50. Intracardiac Vortex Dynamics by High-Frame-Rate Doppler Vortography— In Vivo Comparison With Vector Flow Mapping and 4-D Flow MRI

Author

Faurie, Julia, Baudet, Mathilde, Assi, Kondo Claude, Auger, Dominique, Gilbert, Guillaume, Tournoux, François, Garcia, Damien, Université de Montréal (UdeM), Laboratoire Biogéochimie des Contaminants Métalliques (LBCM), Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Centre atlantique, Nantes, Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] (CRCTB), Université Bordeaux Segalen - Bordeaux 2-CHU Bordeaux [Bordeaux]-Institut National de la Santé et de la Recherche Médicale (INSERM), Biomarqueurs CArdioNeuroVASCulaires (BioCANVAS), Université Paris 13 (UP13)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier de l'Université de Montréal (CHUM), Imagerie Ultrasonore, Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[PHYS.PHYS.PHYS-FLU-DYN]Physics [physics]/Physics [physics]/Fluid Dynamics [physics.flu-dyn], [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, [INFO.INFO-TS]Computer Science [cs]/Signal and Image Processing, [INFO.INFO-IM]Computer Science [cs]/Medical Imaging, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2017

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