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1. Controlling Risks in the Compounding Process of Individually Formulated Parenteral Nutrition: Use of the FMECA Method (Failure modes, effects, and Criticality Analysis)

Author

Royer Mathilde, Libessart Maïté, Dubaele Jean-Marc, Tourneux Pierre, and Marçon Fréderic

Subjects
nutrition, healthcare quality, pediatrics, infusion, prescribing, Therapeutics. Pharmacology, RM1-950, Pharmaceutical industry, HD9665-9675
Abstract

Parenteral nutrition (PN) in the neonatal intensive care unit (NICU) involves a succession of risky processes. The objective was to identify and prioritize the risks associated with PN in order to improve the quality of the pathway. A failure modes, effects, and criticality analysis (FMECA) was used to identify potential PN pathway failure modes. A multidisciplinary working group conducted a functional analysis of the processes, then listed the failure modes (FM). The FM criticality was assessed on a scale from 1 to 5 for occurrence (O), severity (S), and detection (D). The risk priority number (RPN), ranging from 1 to 125, was calculated. The FMECA identified 99 FM (prescription (n=28), preparation (n=48), and administration (n=23)). The median RPN was 12, with scores ranging from 3 to 48. 25 % of the scores had an RPN>21.75.

Published
2020
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5. L’enveloppement, l’habillage et les tissus en contact avec l’enfant en néonatologie

Author

Allen, A., Audeoud, F., Bouvard, C., Brandicourt, A., Caeymaex, L., Duboz, M.A., Evrard, A., Fichtner, C., Fischer-Fumeaux, C., Girard, L., Gonnaud, F., Hüppi, P., Knezovic, N., Kuhn, P., Laprugne-Garcia, E., Legouais, S., Mons, F., Muller, J.-B., Picaud, J.-C., Pierrat, V., Pladys, P., Reynaud, A., Renesme, L., Rideau, A., Sizun, J., Souet, G., Thiriez, G., Tourneux, P., Touzet, M., Truffert, P., Tscherning, C., Zaoui, C., Zana-Taieb, E., Zores-Koenig, C., Berne Audéoud, F., and Lenglemetz, S.L.

Published
2023
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13. Accès et rôle des parents en néonatalogie en période d’épidémie COVID-19 — Propositions du GREEN de la SFN

Author

Allen, A., Audeoud, F., Bouvard, C., Brandicourt, A., Caeymaex, L., Duboz, M.A., Evrard, A., Fichtner, C., Fischer-Fumeaux, C., Girard, L., Gonnaud, F., Hüppi, P., Knezovic, N., Kuhn, P., Laprugne-Garcia, E., Legouais, S., Mons, F., Muller, J.-B., Picaud, J.-C., Pierrat, V., Pladys, P., Reynaud, A., Renesme, L., Rideau, A., Sizun, J., Souet, G., Thiriez, G., Tourneux, P., Touzet, M., Truffert, P., Tscherning, C., Zaoui, C., Zana-Taieb, E., and Zores, C.

Published
2020
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16. Surgical mask on top of high-flow nasal cannula improves oxygenation in critically ill COVID-19 patients with hypoxemic respiratory failure

Author

Virginie Montiel, Arnaud Robert, Annie Robert, Anas Nabaoui, Tourneux Marie, Natalia Morales Mestre, Maerckx Guillaume, Pierre-François Laterre, and Xavier Wittebole

Subjects
Hypoxemic failure, High-flow nasal cannula, COVID-19 patient, Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9
Abstract

Abstract Objective Critically ill patients admitted in ICU because of COVID-19 infection display severe hypoxemic respiratory failure. The Surviving Sepsis Campaign recommends oxygenation through high-flow nasal cannula over non-invasive ventilation. The primary outcome of our study was to evaluate the effect of the addition of a surgical mask on a high-flow nasal cannula system on oxygenation parameters in hypoxemic COVID-19 patients admitted in ICU who do not require urgent intubation. The secondary outcomes were relevant changes in PaCO2 associated with clinical modifications and patient’s feelings. Design We prospectively assessed 21 patients admitted in our mixed Intensive Care Unit of the Cliniques Universitaires Saint Luc. Main results While FiO2 was unchanged, we demonstrate a significant increase of PaO2 (from 59 (± 6), to 79 mmHg (± 16), p

Published
2020
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19. Effect of multi-lumen perfusion line on catheter-related bacteremia in premature infants: study protocol for a cluster-randomized crossover trial

Author

Aurélie Maiguy-Foinard, Bertrand Décaudin, Pierre Tourneux, Bernard Guillois, Thierry Blanc, Sophie Galène-Gromez, Morgane Masse, Pascal Odou, Fannette Denies, Benoît Dervaux, Alain Duhamel, and Laurent Storme

Subjects
Premature infants, Catheter-related bacteremia, Infusion device, Neonatal intensive care, Central venous catheter, Drug infusion systems, Medicine (General), R5-920
Abstract

Abstract Background Catheter-related bacteremia (CRB) is the most frequent nosocomial infection in neonatal intensive care unit (NICU) patients, especially in very low-birth-weight infants. Administration of injectable drugs in premature newborn infants has many particularities and several types of infusion incidents have been reported. The Edelvaiss® Multiline NEO device is a novel multi-lumen access infusion device adapted to the specificities of infusion in neonatology. This multicenter, randomized, controlled study was therefore designed to determine whether or not Edelvaiss® Multiline NEO reduces the risk of CRB in preterm newborn infants in an NICU. Methods/design This is a multicenter, randomized, controlled trial, using a cluster-randomized crossover design. Four investigator centers (four clusters) will participate in the study and will be randomized into two groups, corresponding to two different sequences (either the Edelvaiss® Multiline NEO or standard infusion system sequence, then vice versa). A total of 280 patients will be recruited. Infants will be enrolled in the study at the time of placing a single-lumen central venous catheter. Three visits recording specific data are planned in the study protocol. The primary outcome measure is the incidence density (ID) of CRB. For each patient, the total number of catheters and CRB incidents as well as the duration of stay in the NICU will be computed and considered for analysis. Discussion The study will provide high-quality evidence to determine whether the Multiline NEO device reduces the risk of CRB in preterm newborns in NICUs or not. Trial registration ClinicalTrials.gov, NCT02633124. Registered on 7 December 2015.

Published
2019
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20. Le portage des nouveau-nés en peau à peau

Author

Allen, A., Audeoud, F., Bouvard, C., Brandicourt, A., Casper, C., Cayemaex, L., Denoual, H., Duboz, M.A., Evrard, A., Fichtner, C., Fischer-Fumeaux, C., Girard, L., Gonnaud, F., Haumont, D., Hüppi, P., Knezovic, N., Kuhn, P., Laprugne-Garcia, E., Legouais, S., Mons, F., Pelofy, V., Picaud, J.-C., Pierrat, V., Renaud, A., Renesme, L., Sizun, J., Souet, G., Thiriez, G., Tourneux, P., Touzet, M., Truffert, P., Zaoui, C., Zana-Taieb, E., Zores, C., and Zaoui-Grattepanche, C.

Published
2018
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21. La famille dans les unités de médecine néonatale

Author

Allen, A., Audeoud, F., Bouvard, C., Brandicourt, A., Casper, C., Cayemaex, L., Denoual, H., Duboz, M.A., Evrard, A., Fichtner, C., Fischer-Fumeaux, C., Girard, L., Gonnaud, F., Haumont, D., Hüppi, P., Knezovic, N., Kuhn, P., Laprugne-Garcia, E., Legouais, S., Mons, F., Pelofy, V., Picaud, J.-C., Pierrat, V., Renaud, A., Renesme, L., Sizun, J., Souet, G., Thiriez, G., Tourneux, P., Touzet, M., Truffert, P., Zaoui, C., Zana-Taieb, E., Zores, C., and Reynaud, A.

Published
2018
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25. Recommendation for hygiene and topical in neonatology from the French Neonatal Society

Author

Renesme, Laurent, Allen, A., Audeoud, F., Bouvard, C., Brandicourt, A., Casper, C., Cayemaex, L., Denoual, H., Duboz, M. A., Evrard, A., Fichtner, C., Fischer-Fumeaux, C. J., Girard, L., Gonnaud, F., Haumont, D., Hüppi, P., Knezovic, N., Laprugne-Garcia, E., Legouais, S., Mons, F., Pelofy, V., Picaud, J. C., Pierrat, V., Pladys, P., Reynaud, A., Souet, G., Thiriez, G., Tourneux, P., Touzet, M., Truffert, P., Zaoui, C., Zana-Taieb, E., Zores, C., Sizun, J., and Kuhn, P.

Published
2019
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27. Parcours clinique et paraclinique de l’enfant suspect de maltraitance et influence sur le signalement

Author

Jardé, Olivier, Manoeuvrier, Florian, Manaouil, Cécile, Gouron, Richard, Berquin, Patrick, Tourneux, Pierre, and Klein, Céline

Abstract

La maltraitance physique concerne 4 % à 20 % des enfants par an. Il existe un défaut diagnostic des situations de maltraitance. L’objectif principal était de déterminer l’influence de facteurs cliniques et paracliniques dans la prise en charge de l’enfant maltraité. Il s’agit d’une étude rétrospective sur le CHU d’Amiens des patients de moins de 3ans suspects de maltraitance, hospitalisés entre le 01/12/2013 et le 01/04/2019. Les données cliniques et paracliniques ont été recueillies dans le dossier médical. Nous avons inclus 126 enfants avec un âge moyen 7,7 mois (0,4–33 mois). Une symptomatologie neurologique (OR IC95 % : 5,5 [1,3–23,4]) ou orthopédique (OR IC95 % : 6,0 [1,0–35,4]) étaient significativement liées à la réalisation d’un signalement. Un résultat compatible avec des lésions de maltraitance à l’IRMc (OR IC95 % : 7,3 [3,2–16,7]), à la scintigraphie osseuse (OR IC95 % : 11,0 [1,3–90,2]) et au fond d’œil (OR IC95 % : 9,1 [2,5–33,3]) était significativement lié à la réalisation d’un signalement. La prise en charge par des services peu qualifiés dans la prise en charge des situations de maltraitance est un facteur de risque de non réalisation des examens complémentaires adéquats nécessaires au diagnostic. La maltraitance infantile est un diagnostic difficile et sa prise en charge fait appel à des connaissances et des compétences médicales spécialisées. Le recours aux différents examens complémentaires est essentiel au diagnostic et fait appels à un travail en équipe spécialisée. Cependant, il ne faut pas oublier que certains signes cliniques non spécifiques peuvent dans certains cas être liés à une maltraitance.

Published
2024
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30. L’enveloppement, l’habillage et les tissus en contact avec l’enfant en néonatologie

Author

Berne Audéoud, F., primary, Lenglemetz, S.L., additional, Touzet, M., additional, Thiriez, G., additional, Allen, A., additional, Audeoud, F., additional, Bouvard, C., additional, Brandicourt, A., additional, Caeymaex, L., additional, Duboz, M.A., additional, Evrard, A., additional, Fichtner, C., additional, Fischer-Fumeaux, C., additional, Girard, L., additional, Gonnaud, F., additional, Hüppi, P., additional, Knezovic, N., additional, Kuhn, P., additional, Laprugne-Garcia, E., additional, Legouais, S., additional, Mons, F., additional, Muller, J.-B., additional, Picaud, J.-C., additional, Pierrat, V., additional, Pladys, P., additional, Reynaud, A., additional, Renesme, L., additional, Rideau, A., additional, Sizun, J., additional, Souet, G., additional, Tourneux, P., additional, Truffert, P., additional, Tscherning, C., additional, Zaoui, C., additional, Zana-Taieb, E., additional, and Zores-Koenig, C., additional

Published
2023
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36. Linguistic and cultural pitfalls of patient-carer communication in the official health care structures of North Cameroon

Author

Henry Tourneux and Hadidja Hadidja Konaï

Subjects
Cameroon, health, multilingualism, cross-cultural communication, Ethnology. Social and cultural anthropology, GN301-674, Philology. Linguistics, P1-1091, African languages and literature, PL8000-8844
Abstract

North Cameroon displays nearly sixty local languages for an estimated 3,500,000 people. Such a multilingualism is offset by the use of a major trade language, Fulfulde or Fula (spoken by Fulɓe or Fulani), which allows basic exchanges to take place in many settings. Owing to increased rates of school attendance, French has been taking on a greater but still limited role in interethnic communication. The question of language comes immediately to the fore in any medical consultation, yet there are also prior cultural factors in play which have a strong impact on the procedure.

Published
2016

37. Can Mathematical Models of Body Heat Exchanges Accurately Predict Thermal Stress in Premature Neonates?

Author

Stéphane Delanaud, Fatima Chahin Yassin, Estelle Durand, Pierre Tourneux, and Jean-Pierre Libert

Subjects
model, neonate, body heat exchange, nursing care, incubator, thermal management, Technology, Engineering (General). Civil engineering (General), TA1-2040, Biology (General), QH301-705.5, Physics, QC1-999, Chemistry, QD1-999
Abstract

Mathematical models of body heat exchanges can be used to define the thermal limits needed to protect premature neonates nursed in incubators against thermal stress–stress that can have potentially devastating impairments on neurological development and body growth. Predictive models can help caregivers to keep a neonate’s body temperature within the normal range and to solve problems that arise during intensive care, such as the risk of hyperthermia during phototherapy, the risk of hypothermia during transport from one clinical centre to another, and the use of a plastic bag to reduce skin water loss and body dehydration. Here, we review the strengths and limitations of models used to predict the risk of thermal stress, with a focus on uncertainties in the algorithms governing heat transfers between the neonate’s skin and the complicated thermal environment encountered in incubators. We describe attempts to reduce the large number of empirical assumptions and uncertainties in this field, and suggest ways of more accurately modelling optimal thermal conditions for neonates nursed in closed incubators.

Published
2019
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42. La personne compétente en radioprotection / le conseiller en radioprotection : historique, constats et enjeux

Author

Ammerich, M., Barbey, P., Beltrami, L.-A., Bergeron, C., Bourdeloie, R., Cordelle, A., Guérin, C., Le Denmat, D., Legrand, L., Luccioni, C., Ménéchal, P., Mora, S., Prieto, D., Romane, P., Sans, P., Tancray, Y., Tourneux, C., Trin, J., Vidal, J.-P., Ammerich, M., Barbey, P., Beltrami, L.-A., Bergeron, C., Bourdeloie, R., Cordelle, A., Guérin, C., Le Denmat, D., Legrand, L., Luccioni, C., Ménéchal, P., Mora, S., Prieto, D., Romane, P., Sans, P., Tancray, Y., Tourneux, C., Trin, J., and Vidal, J.-P.

Abstract

En l’espace d’une cinquantaine d’année, la réglementation a fait de la personne compétente en radioprotection (PCR) l’acteur principal de la radioprotection dans les différents établissements mettant en œuvre des rayonnements ionisants pour assurer la protection des travailleurs – mais aussi depuis peu celle du public – notamment lors de l’utilisation de sources non scellées. La réglementation définit le rôle et les missions de la PCR, précise son articulation avec les autres acteurs et fixe les modalités de sa formation. Les fonctions de la PCR ont par ailleurs sensiblement évolué avec la création des conseillers en radioprotection (CRP). L’objectif de cet article est d’analyser et de comprendre l’évolution historique de la fonction de PCR, exercée actuellement par plus de 10 000 personnes en France, pour mieux en dégager les enjeux de demain.

Published
2022
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43. Congenital diaphragmatic hernia: does gestational age at diagnosis matter when evaluating morbidity and mortality?

Author

Bouchghoul, Hanane, Senat, Marie-Victoire, Storme, Laurent, de Lagausie, Pascal, Begue, Laetitia, Khen-Dunlop, Naziha, Bouyer, Jean, Benachi, Alexandra, Benoist, G., Biquard, F., Chauleur, C., Desrumaux, A., Favre, R., Gallot, D., Horovitz, J., Lebouar, G., Levard, G., Mace, G., Massardier, J., Morel, O., Perrotin, F., Riethmuller, D., Rosenblat, J., Saliou, A. H., Sauvat, F., Tourneux, P., Trastour, C., Vayssière, C., Verspik, E., and Winer, N.

Published
2015
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45. Palladate Salts from Chiral Pyridinium Ionic Liquids: Synthesis and Crystal Structures

Author

Nancy Lauth-de Viguerie, Jean-Daniel Marty, Heinz Gornitzka, and Emmanuel Tourneux

Subjects
Chiral Ionic Liquids, Pyridinium, Transition metal complexes, Palladium, Organic chemistry, QD241-441
Abstract

This paper reports the preparation, characterization and the crystal X-ray structures of metal-containing ionic liquid complexes based on chiral pyridinium cations and tetrachloropalladate (II) [PdCl4]2-.

Published
2007
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