384 results on '"Totoki, Yasushi"'
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2. Genomic and Pathologic Profiling of Very Well-Differentiated Gastric Adenocarcinoma of Intestinal Type: A Study With Emphasis on Diffuse-Type Transformation
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Rokutan, Hirofumi, Arai, Yasuhito, Kunita, Akiko, Yamasaki, Satoshi, Nakamura, Hiromi, Hama, Natsuko, Nakayama, Atsuhito, Hosoda, Fumie, Totoki, Yasushi, Fujishiro, Mitsuhiro, Seto, Yasuyuki, Shibata, Tatsuhiro, and Ushiku, Tetsuo
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- 2024
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3. Genomic and epigenomic integrative subtypes of renal cell carcinoma in a Japanese cohort
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Fukagawa, Akihiko, Hama, Natsuko, Totoki, Yasushi, Nakamura, Hiromi, Arai, Yasuhito, Saito-Adachi, Mihoko, Maeshima, Akiko, Matsui, Yoshiyuki, Yachida, Shinichi, Ushiku, Tetsuo, and Shibata, Tatsuhiro
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- 2023
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4. Oncogenic structural aberration landscape in gastric cancer genomes
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Saito-Adachi, Mihoko, Hama, Natsuko, Totoki, Yasushi, Nakamura, Hiromi, Arai, Yasuhito, Hosoda, Fumie, Rokutan, Hirofumi, Yachida, Shinichi, Kato, Mamoru, Fukagawa, Akihiko, and Shibata, Tatsuhiro
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- 2023
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5. Multiancestry genomic and transcriptomic analysis of gastric cancer
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Totoki, Yasushi, Saito-Adachi, Mihoko, Shiraishi, Yuichi, Komura, Daisuke, Nakamura, Hiromi, Suzuki, Akihiro, Tatsuno, Kenji, Rokutan, Hirofumi, Hama, Natsuko, Yamamoto, Shogo, Ono, Hanako, Arai, Yasuhito, Hosoda, Fumie, Katoh, Hiroto, Chiba, Kenichi, Iida, Naoko, Nagae, Genta, Ueda, Hiroki, Shihang, Chen, Sekine, Shigeki, Abe, Hiroyuki, Nomura, Sachiyo, Matsuura, Tetsuya, Sakai, Eiji, Ohshima, Takashi, Rino, Yasushi, Yeoh, Khay Guan, So, Jimmy, Sanghvi, Kaushal, Soong, Richie, Fukagawa, Akihiko, Yachida, Shinichi, Kato, Mamoru, Seto, Yasuyuki, Ushiku, Tetsuo, Nakajima, Atsushi, Katai, Hitoshi, Tan, Patrick, Ishikawa, Shumpei, Aburatani, Hiroyuki, and Shibata, Tatsuhiro
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- 2023
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6. Ependymoma with C11orf95-MAML2 fusion: presenting with granular cell and ganglion cell features
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Tamai, Sho, Nakano, Yoshiko, Kinoshita, Masashi, Sabit, Hemragul, Nobusawa, Sumihito, Arai, Yasuhito, Hama, Natsuko, Totoki, Yasushi, Shibata, Tatsuhiro, Ichimura, Koichi, and Nakada, Mitsutoshi
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- 2021
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7. Transcriptome analysis of soybean (Glycine max) root genes differentially expressed in rhizobial, arbuscular mycorrhizal, and dual symbiosis
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Sakamoto, Kazunori, Ogiwara, Natsuko, Kaji, Tomomitsu, Sugimoto, Yurie, Ueno, Mitsuru, Sonoda, Masatoshi, Matsui, Akihiro, Ishida, Junko, Tanaka, Maho, Totoki, Yasushi, Shinozaki, Kazuo, and Seki, Motoaki
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- 2019
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8. Clinical Utility of Circulating Tumor DNA for Molecular Assessment and Precision Medicine in Pancreatic Cancer
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Takai, Erina, Totoki, Yasushi, Nakamura, Hiromi, Kato, Mamoru, Shibata, Tatsuhiro, Yachida, Shinichi, Gahan, Peter B., editor, Fleischhacker, Michael, editor, and Schmidt, Bernd, editor
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- 2016
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9. Post-mortem Plasma Cell-Free DNA Sequencing: Proof-of-Concept Study for the “Liquid Autopsy”
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Takai, Erina, Maeda, Daichi, Li, Zhuo, Kudo-Asabe, Yukitsugu, Totoki, Yasushi, Nakamura, Hiromi, Nakamura, Akiko, Nakamura, Rumi, Kirikawa, Misato, Ito, Yukinobu, Yoshida, Makoto, Inoue, Takamitsu, Habuchi, Tomonori, Ikoma, Shohei, Katoh, Hiroto, Kato, Mamoru, Shibata, Tatsuhiro, Ishikawa, Shumpei, Yachida, Shinichi, and Goto, Akiteru
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- 2020
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10. Data from Comprehensive Genomic Profiling of Neuroendocrine Carcinomas of the Gastrointestinal System
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Yachida, Shinichi, primary, Totoki, Yasushi, primary, Noë, Michaël, primary, Nakatani, Yoichiro, primary, Horie, Masafumi, primary, Kawasaki, Kenta, primary, Nakamura, Hiromi, primary, Saito-Adachi, Mihoko, primary, Suzuki, Masami, primary, Takai, Erina, primary, Hama, Natsuko, primary, Higuchi, Ryota, primary, Hirono, Seiko, primary, Shiba, Satoshi, primary, Kato, Mamoru, primary, Furukawa, Eisaku, primary, Arai, Yasuhito, primary, Rokutan, Hirofumi, primary, Hashimoto, Taiki, primary, Mitsunaga, Shuichi, primary, Kanda, Mitsuro, primary, Tanaka, Hidenori, primary, Takata, So, primary, Shimomura, Ayaka, primary, Oshima, Minoru, primary, Hackeng, Wenzel M., primary, Okumura, Tomoyuki, primary, Okano, Keiichi, primary, Yamamoto, Masakazu, primary, Yamaue, Hiroki, primary, Morizane, Chigusa, primary, Arihiro, Koji, primary, Furukawa, Toru, primary, Sato, Toshiro, primary, Kiyono, Tohru, primary, Brosens, Lodewijk A.A., primary, Wood, Laura D., primary, Hruban, Ralph H., primary, and Shibata, Tatsuhiro, primary
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- 2023
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11. Supplementary Data from Comprehensive Genomic Profiling of Neuroendocrine Carcinomas of the Gastrointestinal System
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Yachida, Shinichi, primary, Totoki, Yasushi, primary, Noë, Michaël, primary, Nakatani, Yoichiro, primary, Horie, Masafumi, primary, Kawasaki, Kenta, primary, Nakamura, Hiromi, primary, Saito-Adachi, Mihoko, primary, Suzuki, Masami, primary, Takai, Erina, primary, Hama, Natsuko, primary, Higuchi, Ryota, primary, Hirono, Seiko, primary, Shiba, Satoshi, primary, Kato, Mamoru, primary, Furukawa, Eisaku, primary, Arai, Yasuhito, primary, Rokutan, Hirofumi, primary, Hashimoto, Taiki, primary, Mitsunaga, Shuichi, primary, Kanda, Mitsuro, primary, Tanaka, Hidenori, primary, Takata, So, primary, Shimomura, Ayaka, primary, Oshima, Minoru, primary, Hackeng, Wenzel M., primary, Okumura, Tomoyuki, primary, Okano, Keiichi, primary, Yamamoto, Masakazu, primary, Yamaue, Hiroki, primary, Morizane, Chigusa, primary, Arihiro, Koji, primary, Furukawa, Toru, primary, Sato, Toshiro, primary, Kiyono, Tohru, primary, Brosens, Lodewijk A.A., primary, Wood, Laura D., primary, Hruban, Ralph H., primary, and Shibata, Tatsuhiro, primary
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- 2023
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12. Lost expression of AT‐rich interaction domain 1A in the gastric mucosa—A constituent of field cancerization in the stomach
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Abe, Hiroyuki, primary, Rokutan, Hirofumi, additional, Totoki, Yasushi, additional, Nakamura, Hiromi, additional, Shibata, Tatsuhiro, additional, Ushiku, Tetsuo, additional, and Fukayama, Masashi, additional
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- 2023
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13. Supplementary Figures 1-6 from Whole-Genome and Epigenomic Landscapes of Etiologically Distinct Subtypes of Cholangiocarcinoma
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Jusakul, Apinya, primary, Cutcutache, Ioana, primary, Yong, Chern Han, primary, Lim, Jing Quan, primary, Huang, Mi Ni, primary, Padmanabhan, Nisha, primary, Nellore, Vishwa, primary, Kongpetch, Sarinya, primary, Ng, Alvin Wei Tian, primary, Ng, Ley Moy, primary, Choo, Su Pin, primary, Myint, Swe Swe, primary, Thanan, Raynoo, primary, Nagarajan, Sanjanaa, primary, Lim, Weng Khong, primary, Ng, Cedric Chuan Young, primary, Boot, Arnoud, primary, Liu, Mo, primary, Ong, Choon Kiat, primary, Rajasegaran, Vikneswari, primary, Lie, Stefanus, primary, Lim, Alvin Soon Tiong, primary, Lim, Tse Hui, primary, Tan, Jing, primary, Loh, Jia Liang, primary, McPherson, John R., primary, Khuntikeo, Narong, primary, Bhudhisawasdi, Vajaraphongsa, primary, Yongvanit, Puangrat, primary, Wongkham, Sopit, primary, Totoki, Yasushi, primary, Nakamura, Hiromi, primary, Arai, Yasuhito, primary, Yamasaki, Satoshi, primary, Chow, Pierce Kah-Hoe, primary, Chung, Alexander Yaw Fui, primary, Ooi, London Lucien Peng Jin, primary, Lim, Kiat Hon, primary, Dima, Simona, primary, Duda, Dan G., primary, Popescu, Irinel, primary, Broet, Philippe, primary, Hsieh, Sen-Yung, primary, Yu, Ming-Chin, primary, Scarpa, Aldo, primary, Lai, Jiaming, primary, Luo, Di-Xian, primary, Carvalho, André Lopes, primary, Vettore, André Luiz, primary, Rhee, Hyungjin, primary, Park, Young Nyun, primary, Alexandrov, Ludmil B., primary, Gordân, Raluca, primary, Rozen, Steven G., primary, Shibata, Tatsuhiro, primary, Pairojkul, Chawalit, primary, Teh, Bin Tean, primary, and Tan, Patrick, primary
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- 2023
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14. Supplementary Table 5 from Whole-Genome and Epigenomic Landscapes of Etiologically Distinct Subtypes of Cholangiocarcinoma
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Jusakul, Apinya, primary, Cutcutache, Ioana, primary, Yong, Chern Han, primary, Lim, Jing Quan, primary, Huang, Mi Ni, primary, Padmanabhan, Nisha, primary, Nellore, Vishwa, primary, Kongpetch, Sarinya, primary, Ng, Alvin Wei Tian, primary, Ng, Ley Moy, primary, Choo, Su Pin, primary, Myint, Swe Swe, primary, Thanan, Raynoo, primary, Nagarajan, Sanjanaa, primary, Lim, Weng Khong, primary, Ng, Cedric Chuan Young, primary, Boot, Arnoud, primary, Liu, Mo, primary, Ong, Choon Kiat, primary, Rajasegaran, Vikneswari, primary, Lie, Stefanus, primary, Lim, Alvin Soon Tiong, primary, Lim, Tse Hui, primary, Tan, Jing, primary, Loh, Jia Liang, primary, McPherson, John R., primary, Khuntikeo, Narong, primary, Bhudhisawasdi, Vajaraphongsa, primary, Yongvanit, Puangrat, primary, Wongkham, Sopit, primary, Totoki, Yasushi, primary, Nakamura, Hiromi, primary, Arai, Yasuhito, primary, Yamasaki, Satoshi, primary, Chow, Pierce Kah-Hoe, primary, Chung, Alexander Yaw Fui, primary, Ooi, London Lucien Peng Jin, primary, Lim, Kiat Hon, primary, Dima, Simona, primary, Duda, Dan G., primary, Popescu, Irinel, primary, Broet, Philippe, primary, Hsieh, Sen-Yung, primary, Yu, Ming-Chin, primary, Scarpa, Aldo, primary, Lai, Jiaming, primary, Luo, Di-Xian, primary, Carvalho, André Lopes, primary, Vettore, André Luiz, primary, Rhee, Hyungjin, primary, Park, Young Nyun, primary, Alexandrov, Ludmil B., primary, Gordân, Raluca, primary, Rozen, Steven G., primary, Shibata, Tatsuhiro, primary, Pairojkul, Chawalit, primary, Teh, Bin Tean, primary, and Tan, Patrick, primary
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- 2023
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15. Supplementary Methods and Supplementary Figure and Table Legends from Whole-Genome and Epigenomic Landscapes of Etiologically Distinct Subtypes of Cholangiocarcinoma
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Jusakul, Apinya, primary, Cutcutache, Ioana, primary, Yong, Chern Han, primary, Lim, Jing Quan, primary, Huang, Mi Ni, primary, Padmanabhan, Nisha, primary, Nellore, Vishwa, primary, Kongpetch, Sarinya, primary, Ng, Alvin Wei Tian, primary, Ng, Ley Moy, primary, Choo, Su Pin, primary, Myint, Swe Swe, primary, Thanan, Raynoo, primary, Nagarajan, Sanjanaa, primary, Lim, Weng Khong, primary, Ng, Cedric Chuan Young, primary, Boot, Arnoud, primary, Liu, Mo, primary, Ong, Choon Kiat, primary, Rajasegaran, Vikneswari, primary, Lie, Stefanus, primary, Lim, Alvin Soon Tiong, primary, Lim, Tse Hui, primary, Tan, Jing, primary, Loh, Jia Liang, primary, McPherson, John R., primary, Khuntikeo, Narong, primary, Bhudhisawasdi, Vajaraphongsa, primary, Yongvanit, Puangrat, primary, Wongkham, Sopit, primary, Totoki, Yasushi, primary, Nakamura, Hiromi, primary, Arai, Yasuhito, primary, Yamasaki, Satoshi, primary, Chow, Pierce Kah-Hoe, primary, Chung, Alexander Yaw Fui, primary, Ooi, London Lucien Peng Jin, primary, Lim, Kiat Hon, primary, Dima, Simona, primary, Duda, Dan G., primary, Popescu, Irinel, primary, Broet, Philippe, primary, Hsieh, Sen-Yung, primary, Yu, Ming-Chin, primary, Scarpa, Aldo, primary, Lai, Jiaming, primary, Luo, Di-Xian, primary, Carvalho, André Lopes, primary, Vettore, André Luiz, primary, Rhee, Hyungjin, primary, Park, Young Nyun, primary, Alexandrov, Ludmil B., primary, Gordân, Raluca, primary, Rozen, Steven G., primary, Shibata, Tatsuhiro, primary, Pairojkul, Chawalit, primary, Teh, Bin Tean, primary, and Tan, Patrick, primary
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- 2023
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16. Supplementary Table 4 from Whole-Genome and Epigenomic Landscapes of Etiologically Distinct Subtypes of Cholangiocarcinoma
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Jusakul, Apinya, primary, Cutcutache, Ioana, primary, Yong, Chern Han, primary, Lim, Jing Quan, primary, Huang, Mi Ni, primary, Padmanabhan, Nisha, primary, Nellore, Vishwa, primary, Kongpetch, Sarinya, primary, Ng, Alvin Wei Tian, primary, Ng, Ley Moy, primary, Choo, Su Pin, primary, Myint, Swe Swe, primary, Thanan, Raynoo, primary, Nagarajan, Sanjanaa, primary, Lim, Weng Khong, primary, Ng, Cedric Chuan Young, primary, Boot, Arnoud, primary, Liu, Mo, primary, Ong, Choon Kiat, primary, Rajasegaran, Vikneswari, primary, Lie, Stefanus, primary, Lim, Alvin Soon Tiong, primary, Lim, Tse Hui, primary, Tan, Jing, primary, Loh, Jia Liang, primary, McPherson, John R., primary, Khuntikeo, Narong, primary, Bhudhisawasdi, Vajaraphongsa, primary, Yongvanit, Puangrat, primary, Wongkham, Sopit, primary, Totoki, Yasushi, primary, Nakamura, Hiromi, primary, Arai, Yasuhito, primary, Yamasaki, Satoshi, primary, Chow, Pierce Kah-Hoe, primary, Chung, Alexander Yaw Fui, primary, Ooi, London Lucien Peng Jin, primary, Lim, Kiat Hon, primary, Dima, Simona, primary, Duda, Dan G., primary, Popescu, Irinel, primary, Broet, Philippe, primary, Hsieh, Sen-Yung, primary, Yu, Ming-Chin, primary, Scarpa, Aldo, primary, Lai, Jiaming, primary, Luo, Di-Xian, primary, Carvalho, André Lopes, primary, Vettore, André Luiz, primary, Rhee, Hyungjin, primary, Park, Young Nyun, primary, Alexandrov, Ludmil B., primary, Gordân, Raluca, primary, Rozen, Steven G., primary, Shibata, Tatsuhiro, primary, Pairojkul, Chawalit, primary, Teh, Bin Tean, primary, and Tan, Patrick, primary
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- 2023
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17. Supplementary Table 2 from Whole-Genome and Epigenomic Landscapes of Etiologically Distinct Subtypes of Cholangiocarcinoma
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Jusakul, Apinya, primary, Cutcutache, Ioana, primary, Yong, Chern Han, primary, Lim, Jing Quan, primary, Huang, Mi Ni, primary, Padmanabhan, Nisha, primary, Nellore, Vishwa, primary, Kongpetch, Sarinya, primary, Ng, Alvin Wei Tian, primary, Ng, Ley Moy, primary, Choo, Su Pin, primary, Myint, Swe Swe, primary, Thanan, Raynoo, primary, Nagarajan, Sanjanaa, primary, Lim, Weng Khong, primary, Ng, Cedric Chuan Young, primary, Boot, Arnoud, primary, Liu, Mo, primary, Ong, Choon Kiat, primary, Rajasegaran, Vikneswari, primary, Lie, Stefanus, primary, Lim, Alvin Soon Tiong, primary, Lim, Tse Hui, primary, Tan, Jing, primary, Loh, Jia Liang, primary, McPherson, John R., primary, Khuntikeo, Narong, primary, Bhudhisawasdi, Vajaraphongsa, primary, Yongvanit, Puangrat, primary, Wongkham, Sopit, primary, Totoki, Yasushi, primary, Nakamura, Hiromi, primary, Arai, Yasuhito, primary, Yamasaki, Satoshi, primary, Chow, Pierce Kah-Hoe, primary, Chung, Alexander Yaw Fui, primary, Ooi, London Lucien Peng Jin, primary, Lim, Kiat Hon, primary, Dima, Simona, primary, Duda, Dan G., primary, Popescu, Irinel, primary, Broet, Philippe, primary, Hsieh, Sen-Yung, primary, Yu, Ming-Chin, primary, Scarpa, Aldo, primary, Lai, Jiaming, primary, Luo, Di-Xian, primary, Carvalho, André Lopes, primary, Vettore, André Luiz, primary, Rhee, Hyungjin, primary, Park, Young Nyun, primary, Alexandrov, Ludmil B., primary, Gordân, Raluca, primary, Rozen, Steven G., primary, Shibata, Tatsuhiro, primary, Pairojkul, Chawalit, primary, Teh, Bin Tean, primary, and Tan, Patrick, primary
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- 2023
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18. Supplementary Table 1 from Whole-Genome and Epigenomic Landscapes of Etiologically Distinct Subtypes of Cholangiocarcinoma
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Jusakul, Apinya, primary, Cutcutache, Ioana, primary, Yong, Chern Han, primary, Lim, Jing Quan, primary, Huang, Mi Ni, primary, Padmanabhan, Nisha, primary, Nellore, Vishwa, primary, Kongpetch, Sarinya, primary, Ng, Alvin Wei Tian, primary, Ng, Ley Moy, primary, Choo, Su Pin, primary, Myint, Swe Swe, primary, Thanan, Raynoo, primary, Nagarajan, Sanjanaa, primary, Lim, Weng Khong, primary, Ng, Cedric Chuan Young, primary, Boot, Arnoud, primary, Liu, Mo, primary, Ong, Choon Kiat, primary, Rajasegaran, Vikneswari, primary, Lie, Stefanus, primary, Lim, Alvin Soon Tiong, primary, Lim, Tse Hui, primary, Tan, Jing, primary, Loh, Jia Liang, primary, McPherson, John R., primary, Khuntikeo, Narong, primary, Bhudhisawasdi, Vajaraphongsa, primary, Yongvanit, Puangrat, primary, Wongkham, Sopit, primary, Totoki, Yasushi, primary, Nakamura, Hiromi, primary, Arai, Yasuhito, primary, Yamasaki, Satoshi, primary, Chow, Pierce Kah-Hoe, primary, Chung, Alexander Yaw Fui, primary, Ooi, London Lucien Peng Jin, primary, Lim, Kiat Hon, primary, Dima, Simona, primary, Duda, Dan G., primary, Popescu, Irinel, primary, Broet, Philippe, primary, Hsieh, Sen-Yung, primary, Yu, Ming-Chin, primary, Scarpa, Aldo, primary, Lai, Jiaming, primary, Luo, Di-Xian, primary, Carvalho, André Lopes, primary, Vettore, André Luiz, primary, Rhee, Hyungjin, primary, Park, Young Nyun, primary, Alexandrov, Ludmil B., primary, Gordân, Raluca, primary, Rozen, Steven G., primary, Shibata, Tatsuhiro, primary, Pairojkul, Chawalit, primary, Teh, Bin Tean, primary, and Tan, Patrick, primary
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- 2023
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19. Supplementary Table 3 from Whole-Genome and Epigenomic Landscapes of Etiologically Distinct Subtypes of Cholangiocarcinoma
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Jusakul, Apinya, primary, Cutcutache, Ioana, primary, Yong, Chern Han, primary, Lim, Jing Quan, primary, Huang, Mi Ni, primary, Padmanabhan, Nisha, primary, Nellore, Vishwa, primary, Kongpetch, Sarinya, primary, Ng, Alvin Wei Tian, primary, Ng, Ley Moy, primary, Choo, Su Pin, primary, Myint, Swe Swe, primary, Thanan, Raynoo, primary, Nagarajan, Sanjanaa, primary, Lim, Weng Khong, primary, Ng, Cedric Chuan Young, primary, Boot, Arnoud, primary, Liu, Mo, primary, Ong, Choon Kiat, primary, Rajasegaran, Vikneswari, primary, Lie, Stefanus, primary, Lim, Alvin Soon Tiong, primary, Lim, Tse Hui, primary, Tan, Jing, primary, Loh, Jia Liang, primary, McPherson, John R., primary, Khuntikeo, Narong, primary, Bhudhisawasdi, Vajaraphongsa, primary, Yongvanit, Puangrat, primary, Wongkham, Sopit, primary, Totoki, Yasushi, primary, Nakamura, Hiromi, primary, Arai, Yasuhito, primary, Yamasaki, Satoshi, primary, Chow, Pierce Kah-Hoe, primary, Chung, Alexander Yaw Fui, primary, Ooi, London Lucien Peng Jin, primary, Lim, Kiat Hon, primary, Dima, Simona, primary, Duda, Dan G., primary, Popescu, Irinel, primary, Broet, Philippe, primary, Hsieh, Sen-Yung, primary, Yu, Ming-Chin, primary, Scarpa, Aldo, primary, Lai, Jiaming, primary, Luo, Di-Xian, primary, Carvalho, André Lopes, primary, Vettore, André Luiz, primary, Rhee, Hyungjin, primary, Park, Young Nyun, primary, Alexandrov, Ludmil B., primary, Gordân, Raluca, primary, Rozen, Steven G., primary, Shibata, Tatsuhiro, primary, Pairojkul, Chawalit, primary, Teh, Bin Tean, primary, and Tan, Patrick, primary
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- 2023
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20. Data from Whole-Genome and Epigenomic Landscapes of Etiologically Distinct Subtypes of Cholangiocarcinoma
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Jusakul, Apinya, primary, Cutcutache, Ioana, primary, Yong, Chern Han, primary, Lim, Jing Quan, primary, Huang, Mi Ni, primary, Padmanabhan, Nisha, primary, Nellore, Vishwa, primary, Kongpetch, Sarinya, primary, Ng, Alvin Wei Tian, primary, Ng, Ley Moy, primary, Choo, Su Pin, primary, Myint, Swe Swe, primary, Thanan, Raynoo, primary, Nagarajan, Sanjanaa, primary, Lim, Weng Khong, primary, Ng, Cedric Chuan Young, primary, Boot, Arnoud, primary, Liu, Mo, primary, Ong, Choon Kiat, primary, Rajasegaran, Vikneswari, primary, Lie, Stefanus, primary, Lim, Alvin Soon Tiong, primary, Lim, Tse Hui, primary, Tan, Jing, primary, Loh, Jia Liang, primary, McPherson, John R., primary, Khuntikeo, Narong, primary, Bhudhisawasdi, Vajaraphongsa, primary, Yongvanit, Puangrat, primary, Wongkham, Sopit, primary, Totoki, Yasushi, primary, Nakamura, Hiromi, primary, Arai, Yasuhito, primary, Yamasaki, Satoshi, primary, Chow, Pierce Kah-Hoe, primary, Chung, Alexander Yaw Fui, primary, Ooi, London Lucien Peng Jin, primary, Lim, Kiat Hon, primary, Dima, Simona, primary, Duda, Dan G., primary, Popescu, Irinel, primary, Broet, Philippe, primary, Hsieh, Sen-Yung, primary, Yu, Ming-Chin, primary, Scarpa, Aldo, primary, Lai, Jiaming, primary, Luo, Di-Xian, primary, Carvalho, André Lopes, primary, Vettore, André Luiz, primary, Rhee, Hyungjin, primary, Park, Young Nyun, primary, Alexandrov, Ludmil B., primary, Gordân, Raluca, primary, Rozen, Steven G., primary, Shibata, Tatsuhiro, primary, Pairojkul, Chawalit, primary, Teh, Bin Tean, primary, and Tan, Patrick, primary
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- 2023
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21. Post-mortem Plasma Cell-Free DNA Sequencing: Proof-of-Concept Study for the Liquid Autopsy
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Takai, Erina, Maeda, Daichi, Li, Zhuo, Kudo-Asabe, Yukitsugu, Totoki, Yasushi, Nakamura, Hiromi, Nakamura, Akiko, Nakamura, Rumi, Kirikawa, Misato, Ito, Yukinobu, Yoshida, Makoto, Inoue, Takamitsu, Habuchi, Tomonori, Ikoma, Shohei, Katoh, Hiroto, Kato, Mamoru, Shibata, Tatsuhiro, Ishikawa, Shumpei, Yachida, Shinichi, Goto, Akiteru, Takai, Erina, Maeda, Daichi, Li, Zhuo, Kudo-Asabe, Yukitsugu, Totoki, Yasushi, Nakamura, Hiromi, Nakamura, Akiko, Nakamura, Rumi, Kirikawa, Misato, Ito, Yukinobu, Yoshida, Makoto, Inoue, Takamitsu, Habuchi, Tomonori, Ikoma, Shohei, Katoh, Hiroto, Kato, Mamoru, Shibata, Tatsuhiro, Ishikawa, Shumpei, Yachida, Shinichi, and Goto, Akiteru
- Abstract
Recent genomic studies on cancer tissues obtained during rapid autopsy have provided insights into the clonal evolution and heterogeneity of cancer. However, post-mortem blood has not been subjected to genetic analyses in relation to cancer. We first confirmed that substantial quantities of cell-free DNA were present in the post-mortem plasma of 12 autopsy cases. Then, we focused on a pilot case of prostate cancer with multiple metastases for genetic analyses. Whole-exome sequencing of post-mortem plasma-derived cell-free DNA and eight frozen metastatic cancer tissues collected during rapid autopsy was performed, and compared their mutational statuses. The post-mortem plasma cell-free DNA was successfully sequenced and 344 mutations were identified. Of these, 160 were detected in at least one of the metastases. Further, 99% of the mutations shared by all metastases were present in the plasma. Sanger sequencing of 30 additional formalin-fixed metastases enabled us to map the clones harboring mutations initially detected only in the plasma. In conclusion, post-mortem blood, which is usually disposed of during conventional autopsies, can provide valuable data if sequenced in detail, especially regarding cancer heterogeneity. Furthermore, post-mortem plasma cell-free DNA sequencing (liquid autopsy) can be a novel platform for cancer research and a tool for genomic pathology.
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- 2023
22. Variegated RHOA mutations in adult T-cell leukemia/lymphoma
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Nagata, Yasunobu, Kontani, Kenji, Enami, Terukazu, Kataoka, Keisuke, Ishii, Ryohei, Totoki, Yasushi, Kataoka, Tatsuki R., Hirata, Masahiro, Aoki, Kazuhiro, Nakano, Kazumi, Kitanaka, Akira, Sakata-Yanagimoto, Mamiko, Egami, Sachiko, Shiraishi, Yuichi, Chiba, Kenichi, Tanaka, Hiroko, Shiozawa, Yusuke, Yoshizato, Tetsuichi, Suzuki, Hiromichi, Kon, Ayana, Yoshida, Kenichi, Sato, Yusuke, Sato-Otsubo, Aiko, Sanada, Masashi, Munakata, Wataru, Nakamura, Hiromi, Hama, Natsuko, Miyano, Satoru, Nureki, Osamu, Shibata, Tatsuhiro, Haga, Hironori, Shimoda, Kazuya, Katada, Toshiaki, Chiba, Shigeru, Watanabe, Toshiki, and Ogawa, Seishi
- Published
- 2016
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23. Mutational signatures associated with tobacco smoking in human cancer
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Alexandrov, Ludmil B., Ju, Young Seok, Haase, Kerstin, Van Loo, Peter, Martincorena, Iñigo, Nik-Zainal, Serena, Totoki, Yasushi, Fujimoto, Akihiro, Nakagawa, Hidewaki, Shibata, Tatsuhiro, Campbell, Peter J., Vineis, Paolo, Phillips, David H., and Stratton, Michael R.
- Published
- 2016
24. A deep learning system accurately classifies primary and metastatic cancers using passenger mutation patterns
- Author
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Paresh, Vázquez-García, Ignacio, Waddell, Nick M, Waddell, Nicola, Wadelius, Claes, Wadi, Lina, Wagener, Rabea, Wala, Jeremiah A, Wang, Jian, Wang, Jiayin, Wang, Linghua, Wang, Qi, Wang, Wenyi, Wang, Yumeng, Wang, Zhining, Waring, Paul M, Warnatz, Hans-Jörg, Warrell, Jonathan, Warren, Anne Y, Waszak, Sebastian M, Wedge, David C, Weichenhan, Dieter, Weinberger, Paul, Weinstein, John N, Weischenfeldt, Joachim, Weisenberger, Daniel J, Welch, Ian, Wendl, Michael C, Werner, Johannes, Whalley, Justin P, Wheeler, David A, Whitaker, Hayley C, Wigle, Dennis, Wilkerson, Matthew D, Williams, Ashley, Wilmott, James S, Wilson, Gavin W, Wilson, Julie M, Wilson, Richard K, Winterhoff, Boris, Wintersinger, Jeffrey A, Wiznerowicz, Maciej, Wolf, Stephan, Wong, Bernice H, Wong, Tina, Wong, Winghing, Woo, Youngchoon, Wood, Scott, Wouters, Bradly G, Wright, Adam J, Wright, Mark H, Wu, Dai-Ying, Wu, Guanming, Wu, Jianmin, Wu, Kui, Wu, Yang, Wu, Zhenggang, Xi, Liu, Xia, Tian, Xiang, Qian, Xiao, Xiao, Xing, Rui, Xiong, Heng, Xu, Qinying, Xu, Yanxun, Xue, Hong, Yachida, Shinichi, Yakneen, Sergei, Yamaguchi, Rui, Yamaguchi, Takafumi N, Yamamoto, Masakazu, Yamamoto, Shogo, Yamaue, Hiroki, Yang, Fan, Yang, Huanming, Yang, Jean Y, Yang, Liming, Yang, Lixing, Yang, Shanlin, Yang, Tsun-Po, Yang, Yang, Yao, Xiaotong, Yaspo, Marie-Laure, Yates, Lucy, Yau, Christina, Ye, Chen, Ye, Kai, Yellapantula, Venkata D, Yoon, Christopher J, Yoon, Sung-Soo, Yousif, Fouad, Yu, Jun, Yu, Kaixian, Yu, Willie, Yu, Yingyan, Yuan, Yuan, Yuen, Denis, Yung, Christina K, Zaikova, Olga, Zamora, Jorge, Zapatka, Marc, Zenklusen, Jean C, Zenz, Thorsten, Zeps, Nikolajs, Zhang, Cheng-Zhong, Zhang, Fan, Zhang, Hailei, Zhang, Hongwei, Zhang, Hongxin, Zhang, Jiashan, Zhang, Jing, Zhang, Xiuqing, Zhang, Xuanping, Zhang, Yan, Zhang, Zemin, Zhao, Zhongming, Zheng, Liangtao, Zheng, Xiuqing, Zhou, Wanding, Zhou, Yong, Zhu, Bin, Zhu, Hongtu, Zhu, Jingchun, Zhu, Shida, Zou, Lihua, Zou, Xueqing, deFazio, Anna, van As, Nicholas, van Deurzen, Carolien HM, van de Vijver, Marc J, Veer, L van’t, and von Mering, Christian
- Subjects
Human Biology & Physiology ,Ecology,Evolution & Ethology ,Tumour Biology ,Genetics & Genomics ,Structural Biology & Biophysics ,Computational & Systems Biology - Abstract
In cancer, the primary tumour’s organ of origin and histopathology are the strongest determinants of its clinical behaviour, but in 3% of cases a patient presents with a metastatic tumour and no obvious primary. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, we train a deep learning classifier to predict cancer type based on patterns of somatic passenger mutations detected in whole genome sequencing (WGS) of 2606 tumours representing 24 common cancer types produced by the PCAWG Consortium. Our classifier achieves an accuracy of 91% on held-out tumor samples and 88% and 83% respectively on independent primary and metastatic samples, roughly double the accuracy of trained pathologists when presented with a metastatic tumour without knowledge of the primary. Surprisingly, adding information on driver mutations reduced accuracy. Our results have clinical applicability, underscore how patterns of somatic passenger mutations encode the state of the cell of origin, and can inform future strategies to detect the source of circulating tumour DNA.
- Published
- 2023
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25. Combined burden and functional impact tests for cancer driver discovery using DriverPower
- Author
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Human Biology & Physiology ,Ecology,Evolution & Ethology ,Tumour Biology ,Genetics & Genomics ,Structural Biology & Biophysics ,Computational & Systems Biology - Abstract
The discovery of driver mutations is one of the key motivations for cancer genome sequencing. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2658 cancers across 38 tumour types, we describe DriverPower, a software package that uses mutational burden and functional impact evidence to identify driver mutations in coding and non-coding sites within cancer whole genomes. Using a total of 1373 genomic features derived from public sources, DriverPower’s background mutation model explains up to 93% of the regional variance in the mutation rate across multiple tumour types. By incorporating functional impact scores, we are able to further increase the accuracy of driver discovery. Testing across a collection of 2583 cancer genomes from the PCAWG project, DriverPower identifies 217 coding and 95 non-coding driver candidates. Comparing to six published methods used by the PCAWG Drivers and Functional Interpretation Working Group, DriverPower has the highest F1 score for both coding and non-coding driver discovery. This demonstrates that DriverPower is an effective framework for computational driver discovery.
- Published
- 2023
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26. Integrative pathway enrichment analysis of multivariate omics data
- Author
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Vijver, Marc J, and Veer, L van’t
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Human Biology & Physiology ,Ecology,Evolution & Ethology ,Tumour Biology ,Genetics & Genomics ,Structural Biology & Biophysics ,Computational & Systems Biology - Abstract
Multi-omics datasets represent distinct aspects of the central dogma of molecular biology. Such high-dimensional molecular profiles pose challenges to data interpretation and hypothesis generation. ActivePathways is an integrative method that discovers significantly enriched pathways across multiple datasets using statistical data fusion, rationalizes contributing evidence and highlights associated genes. As part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2658 cancers across 38 tumor types, we integrated genes with coding and non-coding mutations and revealed frequently mutated pathways and additional cancer genes with infrequent mutations. We also analyzed prognostic molecular pathways by integrating genomic and transcriptomic features of 1780 breast cancers and highlighted associations with immune response and anti-apoptotic signaling. Integration of ChIP-seq and RNA-seq data for master regulators of the Hippo pathway across normal human tissues identified processes of tissue regeneration and stem cell regulation. ActivePathways is a versatile method that improves systems-level understanding of cellular organization in health and disease through integration of multiple molecular datasets and pathway annotations.
- Published
- 2023
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27. Pathway and network analysis of more than 2500 whole cancer genomes
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Human Biology & Physiology ,Ecology,Evolution & Ethology ,Tumour Biology ,Genetics & Genomics ,Structural Biology & Biophysics ,Computational & Systems Biology - Abstract
The catalog of cancer driver mutations in protein-coding genes has greatly expanded in the past decade. However, non-coding cancer driver mutations are less well-characterized and only a handful of recurrent non-coding mutations, most notably TERT promoter mutations, have been reported. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2658 cancer across 38 tumor types, we perform multi-faceted pathway and network analyses of non-coding mutations across 2583 whole cancer genomes from 27 tumor types compiled by the ICGC/TCGA PCAWG project that was motivated by the success of pathway and network analyses in prioritizing rare mutations in protein-coding genes. While few non-coding genomic elements are recurrently mutated in this cohort, we identify 93 genes harboring non-coding mutations that cluster into several modules of interacting proteins. Among these are promoter mutations associated with reduced mRNA expression in TP53, TLE4, and TCF4. We find that biological processes had variable proportions of coding and non-coding mutations, with chromatin remodeling and proliferation pathways altered primarily by coding mutations, while developmental pathways, including Wnt and Notch, altered by both coding and non-coding mutations. RNA splicing is primarily altered by non-coding mutations in this cohort, and samples containing non-coding mutations in well-known RNA splicing factors exhibit similar gene expression signatures as samples with coding mutations in these genes. These analyses contribute a new repertoire of possible cancer genes and mechanisms that are altered by non-coding mutations and offer insights into additional cancer vulnerabilities that can be investigated for potential therapeutic treatments.
- Published
- 2023
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28. Divergent mutational processes distinguish hypoxic and normoxic tumours
- Author
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Bhandari, Vinayak, Li, Constance H, Bristow, Robert G, Boutros, Paul C, Aaltonen, Lauri A, Abascal, Federico, Abeshouse, Adam, Aburatani, Hiroyuki, Adams, David J, Agrawal, Nishant, Ahn, Keun Soo, Ahn, Sung-Min, Aikata, Hiroshi, Akbani, Rehan, Akdemir, Kadir C, Al-Ahmadie, Hikmat, Al-Sedairy, Sultan T, Al-Shahrour, Fatima, Alawi, Malik, Albert, Monique, Aldape, Kenneth, Alexandrov, Ludmil B, Ally, Adrian, Alsop, Kathryn, Alvarez, Eva G, Amary, Fernanda, Amin, Samirkumar B, Aminou, Brice, Ammerpohl, Ole, Anderson, Matthew J, Ang, Yeng, Antonello, Davide, Anur, Pavana, Aparicio, Samuel, Appelbaum, Elizabeth L, Arai, Yasuhito, Aretz, Axel, Arihiro, Koji, Ariizumi, Shun-ichi, Armenia, Joshua, Arnould, Laurent, Asa, Sylvia, Assenov, Yassen, Atwal, Gurnit, Aukema, Sietse, Auman, J Todd, Aure, Miriam RR, Awadalla, Philip, Aymerich, Marta, Bader, Gary D, Baez-Ortega, Adrian, Bailey, Matthew H, Bailey, Peter J, Balasundaram, Miruna, Balu, Saianand, Bandopadhayay, Pratiti, Banks, Rosamonde E, 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Human Biology & Physiology ,Ecology,Evolution & Ethology ,Tumour Biology ,Genetics & Genomics ,Structural Biology & Biophysics ,Computational & Systems Biology - Abstract
Many primary tumours have low levels of molecular oxygen (hypoxia), and hypoxic tumours respond poorly to therapy. Pan-cancer molecular hallmarks of tumour hypoxia remain poorly understood, with limited comprehension of its associations with specific mutational processes, non-coding driver genes and evolutionary features. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2658 cancers across 38 tumour types, we quantify hypoxia in 1188 tumours spanning 27 cancer types. Elevated hypoxia associates with increased mutational load across cancer types, irrespective of underlying mutational class. The proportion of mutations attributed to several mutational signatures of unknown aetiology directly associates with the level of hypoxia, suggesting underlying mutational processes for these signatures. At the gene level, driver mutations in TP53, MYC and PTEN are enriched in hypoxic tumours, and mutations in PTEN interact with hypoxia to direct tumour evolutionary trajectories. Overall, hypoxia plays a critical role in shaping the genomic and evolutionary landscapes of cancer.
- Published
- 2023
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29. Genomic footprints of activated telomere maintenance mechanisms in cancer
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Prinz, Manuel, Pritchard, Antonia L, Prokopec, Stephenie D, Provenzano, Elena, Puente, Xose S, Puig, Sonia, Pulido-Tamayo, Sergio, Pupo, Gulietta M, Purdie, Colin A, Quinn, Michael C, Rabionet, Raquel, Rader, Janet S, Radlwimmer, Bernhard, Radovic, Petar, Raeder, Benjamin, Raine, Keiran M, Ramakrishna, Manasa, Ramakrishnan, Kamna, Ramalingam, Suresh, Raphael, Benjamin J, Rathmell, W Kimryn, Rausch, Tobias, Reifenberger, Guido, Reimand, Jüri, Reis-Filho, Jorge, Reuter, Victor, Reyes-Salazar, Iker, Reyna, Matthew A, Reynolds, Sheila M, Rheinbay, Esther, Riazalhosseini, Yasser, Richardson, Andrea L, Richter, Julia, Ringel, Matthew, Ringnér, Markus, Rino, Yasushi, Roach, Jeffrey, Roberts, Lewis R, Robertson, A Gordon, Robertson, Alan J, Rodriguez, Javier Bartolomé, Rodríguez-González, F Germán, Roehrl, Michael HA, Rohde, Marius, Rokutan, Hirofumi, Romieu, Gilles, Rooman, Ilse, Roques, Tom, Rosebrock, Daniel, Rosenberg, Mara, Rosenstiel, Philip C, Rosenwald, Andreas, Rowe, Edward W, Royo, Romina, Rozen, Steven G, Rubanova, Yulia, Rubin, Mark A, Rubio-Perez, Carlota, Rudneva, Vasilisa A, Rusev, Borislav C, Ruzzenente, Andrea, Rätsch, Gunnar, Sabarinathan, Radhakrishnan, Sabelnykova, Veronica Y, Sadeghi, Sara, Sahinalp, S Cenk, Saini, Natalie, Saito-Adachi, Mihoko, Saksena, Gordon, Salcedo, Adriana, Salgado, Roberto, Salichos, Leonidas, Sallari, Richard, Saller, Charles, Salvia, Roberto, Sam, Michelle, Samra, Jaswinder S, Sanchez-Vega, Francisco, Sander, Chris, Sanders, Grant, Sarin, Rajiv, Sarrafi, Iman, Sasaki-Oku, Aya, Sauer, Torill, Sauter, Guido, Saw, Robyn PM, Scardoni, Maria, Scarlett, Christopher J, Scarpa, Aldo, Scelo, Ghislaine, Schadendorf, Dirk, Schein, Jacqueline E, Schilhabel, Markus B, Schlomm, Thorsten, Schmidt, Heather K, Schramm, Sarah-Jane, Schreiber, Stefan, Schultz, Nikolaus, Schwarz, Roland F, Scolyer, Richard A, Scott, David, Seethala, Raja, Segre, Ayellet V, Selander, Iris, Semple, Colin A, Senbabaoglu, Yasin, Sengupta, Subhajit, Sereni, Elisabetta, Serra, Stefano, Sgroi, Dennis C, Shah, Nimish C, Shahabi, Sagedeh, Shang, Catherine A, Shang, Ping, Shapira, Ofer, Shelton, Troy, Shen, Ciyue, Shen, Hui, Shepherd, Rebecca, Shi, Ruian, Shi, Yan, Shiah, Yu-Jia, Shibata, Tatsuhiro, Shih, Juliann, Shimizu, Eigo, Shimizu, Kiyo, Shin, Seung Jun, Shiraishi, Yuichi, Shmaya, Tal, Shmulevich, Ilya, Shorser, Solomon I, Short, Charles, Shrestha, Raunak, Shringarpure, Suyash S, Shriver, Craig, Shuai, Shimin, Siebert, Reiner, Sieuwerts, Anieta M, Signoretti, Sabina, Sikora, Katarzyna O, Simbolo, Michele, Simon, Ronald, Simons, Janae V, Simpson, Jared T, Simpson, Peter T, Singer, Samuel, Sinnott-Armstrong, Nasa, Sipahimalani, Payal, Skelly, Tara J, Smid, Marcel, Smith, Jaclyn, Smith-McCune, Karen, Socci, Nicholas D, Sofia, Heidi J, Soloway, Matthew G, Song, Lei, Sood, Anil K, Sothi, Sharmila, Sotiriou, Christos, Soulette, Cameron M, Span, Paul N, Spellman, Paul T, Sperandio, Nicola, Spillane, Andrew J, Spiro, Oliver, Spring, Jonathan, Staaf, Johan, Stadler, Peter F, Staib, Peter, Stark, Stefan G, Stebbings, Lucy, Stefánsson, Ólafur Andri, Stegle, Oliver, Stein, Lincoln D, Stenhouse, Alasdair, Stilgenbauer, Stephan, Stobbe, Miranda D, Stratton, Michael R, Stretch, Jonathan R, Struck, Adam J, Stuart, Joshua M, Stunnenberg, Henk G, Su, Hong, Su, Xiaoping, Sun, Ren X, Sungalee, Stephanie, Susak, Hana, Suzuki, Akihiro, Sweep, Fred, Szczepanowski, Monika, Sültmann, Holger, Yugawa, Takashi, Tam, Angela, Tamborero, David, Tan, Benita Kiat Tee, Tan, Donghui, Tan, Patrick, Tanaka, Hiroko, Taniguchi, Hirokazu, Tanskanen, Tomas J, Tarabichi, Maxime, Tarnuzzer, Roy, Tarpey, Patrick, Taschuk, Morgan L, Tatsuno, Kenji, Tavaré, Simon, Taylor, Darrin F, Taylor-Weiner, Amaro, Teague, Jon W, Teh, Bin Tean, Tembe, Varsha, Temes, Javier, Thai, Kevin, Thayer, Sarah P, Thiessen, Nina, Thomas, Gilles, Thomas, Sarah, Thompson, Alan, Thompson, Alastair M, Thompson, John FF, Thompson, R Houston, Thorne, Heather, Thorne, Leigh B, Thorogood, Adrian, Tiao, Grace, Tijanic, Nebojsa, Timms, Lee E, Tirabosco, Roberto, Tojo, Marta, Tommasi, Stefania, Toon, Christopher W, Toprak, Umut H, Tortora, Giampaolo, Tost, Jörg, Totoki, Yasushi, Townend, David, Traficante, Nadia, Treilleux, Isabelle, Trotta, Jean-Rémi, Trümper, Lorenz HP, Tsao, Ming, Tsunoda, Tatsuhiko, Tucker, Olga, Turkington, Richard, Turner, Daniel J, Tutt, Andrew, Ueno, Masaki, Ueno, Naoto T, Umbricht, Christopher, Umer, Husen M, Underwood, Timothy J, Urban, Lara, Urushidate, Tomoko, Ushiku, Tetsuo, Uusküla-Reimand, Liis, Valencia, Alfonso, Van Den Berg, David J, Van Laere, Steven, Van Loo, Peter, Van Meir, Erwin G, Van den Eynden, Gert G, Van der Kwast, Theodorus, Vasudev, Naveen, Vazquez, Miguel, Vedururu, Ravikiran, Veluvolu, Umadevi, Vembu, Shankar, Verbeke, Lieven PC, Vermeulen, Peter, Verrill, Clare, Viari, Alain, Vicente, David, Vicentini, Caterina, VijayRaghavan, K, Viksna, Juris, Vilain, Ricardo E, Vincent-Salomon, Anne, Visakorpi, Tapio, Voet, Douglas, Vyas, Paresh, Vázquez-García, Ignacio, Waddell, Nick M, Wadelius, Claes, Wadi, Lina, Wagener, Rabea, Wang, Jian, Wang, Jiayin, Wang, Linghua, Wang, Qi, Wang, Wenyi, Wang, Yumeng, Wang, Zhining, Waring, Paul M, Warnatz, Hans-Jörg, Warrell, Jonathan, Warren, Anne Y, Waszak, Sebastian M, Wedge, David C, Weichenhan, Dieter, Weinberger, Paul, Weinstein, John N, Weisenberger, Daniel J, Welch, Ian, Wendl, Michael C, Werner, Johannes, Whalley, Justin P, Wheeler, David A, Whitaker, Hayley C, Wigle, Dennis, Wilkerson, Matthew D, Williams, Ashley, Wilmott, James S, Wilson, Gavin W, Wilson, Julie M, Wilson, Richard K, Winterhoff, Boris, Wintersinger, Jeffrey A, Wiznerowicz, Maciej, Wolf, Stephan, Wong, Bernice H, Wong, Tina, Wong, Winghing, Woo, Youngchoon, Wood, Scott, Wouters, Bradly G, Wright, Adam J, Wright, Derek W, Wright, Mark H, Wu, Chin-Lee, Wu, Dai-Ying, Wu, Guanming, Wu, Jianmin, Wu, Kui, Wu, Yang, Wu, Zhenggang, Xi, Liu, Xia, Tian, Xiang, Qian, Xiao, Xiao, Xing, Rui, Xiong, Heng, Xu, Qinying, Xu, Yanxun, Xue, Hong, Yachida, Shinichi, Yakneen, Sergei, Yamaguchi, Rui, Yamaguchi, Takafumi N, Yamamoto, Masakazu, Yamamoto, Shogo, Yamaue, Hiroki, Yang, Fan, Yang, Huanming, Yang, Jean Y, Yang, Liming, Yang, Shanlin, Yang, Tsun-Po, Yang, Yang, Yaspo, Marie-Laure, Yates, Lucy, Yau, Christina, Ye, Chen, Ye, Kai, Yellapantula, Venkata D, Yoon, Christopher J, Yousif, Fouad, Yu, Jun, Yu, Kaixian, Yu, Willie, Yu, Yingyan, Yuan, Ke, Yuan, Yuan, Yuen, Denis, Yung, Christina K, Zaikova, Olga, Zapatka, Marc, Zenklusen, Jean C, Zenz, Thorsten, Zeps, Nikolajs, Zhang, Fan, Zhang, Hailei, Zhang, Hongwei, Zhang, Hongxin, Zhang, Jiashan, Zhang, Jing, Zhang, Junjun, Zhang, Xiuqing, Zhang, Xuanping, Zhang, Yan, Zhang, Zemin, Zhao, Zhongming, Zheng, Liangtao, Zheng, Xiuqing, Zhou, Wanding, Zhou, Yong, Zhu, Bin, Zhu, Hongtu, Zhu, Jingchun, Zhu, Shida, Zou, Lihua, Zou, Xueqing, deFazio, Anna, van As, Nicholas, van Deurzen, Carolien HM, van de Vijver, Marc J, Veer, L van’t, and von Mering, Christian
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Human Biology & Physiology ,Ecology,Evolution & Ethology ,Tumour Biology ,Genetics & Genomics ,Structural Biology & Biophysics ,Computational & Systems Biology - Abstract
Cancers require telomere maintenance mechanisms for unlimited replicative potential. They achieve this through TERT activation or alternative telomere lengthening associated with ATRX or DAXX loss. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, we dissect whole-genome sequencing data of over 2500 matched tumor-control samples from 36 different tumor types aggregated within the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium to characterize the genomic footprints of these mechanisms. While the telomere content of tumors with ATRX or DAXX mutations (ATRX/DAXXtrunc) is increased, tumors with TERT modifications show a moderate decrease of telomere content. One quarter of all tumor samples contain somatic integrations of telomeric sequences into non-telomeric DNA. This fraction is increased to 80% prevalence in ATRX/DAXXtrunc tumors, which carry an aberrant telomere variant repeat (TVR) distribution as another genomic marker. The latter feature includes enrichment or depletion of the previously undescribed singleton TVRs TTCGGG and TTTGGG, respectively. Our systematic analysis provides new insight into the recurrent genomic alterations associated with telomere maintenance mechanisms in cancer.
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- 2023
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30. Cardiac intimal sarcoma with PDGFRβ mutation and co-amplification of PDGFRα and MDM2: an autopsy case analyzed by whole-exome sequencing
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Ito, Yukinobu, Maeda, Daichi, Yoshida, Makoto, Yoshida, Akihiko, Kudo-Asabe, Yukitsugu, Nanjyo, Hiroshi, Izumi, Chikako, Yamamoto, Fumio, Inoue, Masahiro, Shibata, Hiroyuki, Katoh, Hiroto, Ishikawa, Shumpei, Nakamura, Hiromi, Totoki, Yasushi, Shibata, Tatsuhiro, Yachida, Shinichi, and Goto, Akiteru
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- 2017
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31. Genome-wide methylation profiles in primary intracranial germ cell tumors indicate a primordial germ cell origin for germinomas
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Fukushima, Shintaro, Yamashita, Satoshi, Kobayashi, Hisato, Takami, Hirokazu, Fukuoka, Kohei, Nakamura, Taishi, Yamasaki, Kai, Matsushita, Yuko, Nakamura, Hiromi, Totoki, Yasushi, Kato, Mamoru, Suzuki, Tomonari, Mishima, Kazuhiko, Yanagisawa, Takaaki, Mukasa, Akitake, Saito, Nobuhito, Kanamori, Masayuki, Kumabe, Toshihiro, Tominaga, Teiji, Nagane, Motoo, Iuchi, Toshihiko, Yoshimoto, Koji, Mizoguchi, Masahiro, Tamura, Kaoru, Sakai, Keiichi, Sugiyama, Kazuhiko, Nakada, Mitsutoshi, Yokogami, Kiyotaka, Takeshima, Hideo, Kanemura, Yonehiro, Matsuda, Masahide, Matsumura, Akira, Kurozumi, Kazuhiko, Ueki, Keisuke, Nonaka, Masahiro, Asai, Akio, Kawahara, Nobutaka, Hirose, Yuichi, Takayama, Tatusya, Nakazato, Yoichi, Narita, Yoshitaka, Shibata, Tatsuhiro, Matsutani, Masao, Ushijima, Toshikazu, Nishikawa, Ryo, Ichimura, Koichi, and On behalf of The Intracranial Germ Cell Tumor Genome Analysis Consortium (The iGCTConsortium)
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- 2017
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32. A computational tool to detect DNA alterations tailored to formalin-fixed paraffin-embedded samples in cancer clinical sequencing
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Kato, Mamoru, Nakamura, Hiromi, Nagai, Momoko, Kubo, Takashi, Elzawahry, Asmaa, Totoki, Yasushi, Tanabe, Yuko, Furukawa, Eisaku, Miyamoto, Joe, Sakamoto, Hiromi, Matsumoto, Shingo, Sunami, Kuniko, Arai, Yasuhito, Suzuki, Yutaka, Yoshida, Teruhiko, Tsuchihara, Katsuya, Tamura, Kenji, Yamamoto, Noboru, Ichikawa, Hitoshi, Kohno, Takashi, and Shibata, Tatsuhiro
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- 2018
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33. Aberrant PD-L1 expression through 3'-UTR disruption in multiple cancers
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Kataoka, Keisuke, Shiraishi, Yuichi, Takeda, Yohei, Sakata, Seiji, Matsumoto, Misako, Nagano, Seiji, Maeda, Takuya, Nagata, Yasunobu, Kitanaka, Akira, Mizuno, Seiya, Tanaka, Hiroko, Chiba, Kenichi, Ito, Satoshi, Watatani, Yosaku, Kakiuchi, Nobuyuki, Suzuki, Hiromichi, Yoshizato, Tetsuichi, Yoshida, Kenichi, Sanada, Masashi, Itonaga, Hidehiro, Imaizumi, Yoshitaka, Totoki, Yasushi, Munakata, Wataru, Nakamura, Hiromi, Hama, Natsuko, Shide, Kotaro, Kubuki, Yoko, Hidaka, Tomonori, Kameda, Takuro, Masuda, Kyoko, Minato, Nagahiro, Kashiwase, Koichi, Izutsu, Koji, Takaori-Kondo, Akifumi, Miyazaki, Yasushi, Takahashi, Satoru, Shibata, Tatsuhiro, Kawamoto, Hiroshi, Akatsuka, Yoshiki, Shimoda, Kazuya, Takeuchi, Kengo, Seya, Tsukasa, Miyano, Satoru, and Ogawa, Seishi
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Gene expression -- Health aspects ,Ligands (Biochemistry) -- Properties ,Genetic variation -- Health aspects ,Cancer -- Care and treatment ,Molecular targeted therapy ,Environmental issues ,Science and technology ,Zoology and wildlife conservation - Abstract
Successful treatment of many patients with advanced cancer using antibodies against programmed cell death 1 (PD-1; also known as PDCD1) and its ligand (PD-L1; also known as CD274) has highlighted the critical importance of PD-1/PD-L1-mediated immune escape in cancer development (1-6). However, the genetic basis for the immune escape has not been fully elucidated, with the exception of elevated PD-L1 expression by gene amplification and utilization of an ectopic promoter by translocation, as reported in Hodgkin and other B-cell lymphomas, as well as stomach adenocarcinoma (6-10). Here we show a unique genetic mechanism of immune escape caused by structural variations (SVs) commonly disrupting the 3' region of the PD-L1 gene. Widely affecting multiple common human cancer types, including adult T-cell leukaemia/lymphoma (27%), diffuse large B-cell lymphoma (8%), and stomach adenocarcinoma (2%), these SVs invariably lead to a marked elevation of aberrant PD-L1 transcripts that are stabilized by truncation of the 3'-untranslated region (UTR). Disruption of the Pd-l1 3'-UTR in mice enables immune evasion of EG7-OVA tumour cells with elevated Pd-l1 expression in vivo, which is effectively inhibited by Pd-1/Pd-l1 blockade, supporting the role of relevant SVs in clonal selection through immune evasion. Our findings not only unmask a novel regulatory mechanism of PD-L1 expression, but also suggest that PD-L1 3'-UTR disruption could serve as a genetic marker to identify cancers that actively evade anti-tumour immunity through PD-L1 overexpression., Structural variations, including translocations, inversions, tandem duplications, and deletions, are widely observed across cancer genomes (11,12). Of particular interest are those involving non-coding sequences recently reported for activation of several [...]
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- 2016
34. Recurrent neomorphic mutations of MTOR in central nervous system and testicular germ cell tumors may be targeted for therapy
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Ichimura, Koichi, Fukushima, Shintaro, Totoki, Yasushi, Matsushita, Yuko, Otsuka, Ayaka, Tomiyama, Arata, Niwa, Tohru, Takami, Hirokazu, Nakamura, Taishi, Suzuki, Tomonari, Fukuoka, Kohei, Yanagisawa, Takaaki, Mishima, Kazuhiko, Nakazato, Yoichi, Hosoda, Fumie, Narita, Yoshitaka, Shibui, Soichiro, Yoshida, Akihiko, Mukasa, Akitake, Saito, Nobuhito, Kumabe, Toshihiro, Kanamori, Masayuki, Tominaga, Teiji, Kobayashi, Keiichi, Shimizu, Saki, Nagane, Motoo, Iuchi, Toshihiko, Mizoguchi, Masahiro, Yoshimoto, Koji, Tamura, Kaoru, Maehara, Taketoshi, Sugiyama, Kazuhiko, Nakada, Mitsutoshi, Sakai, Keiichi, Kanemura, Yonehiro, Nonaka, Masahiro, Asai, Akio, Yokogami, Kiyotaka, Takeshima, Hideo, Kawahara, Nobutaka, Takayama, Tatsuya, Yao, Masahiro, Kato, Mamoru, Nakamura, Hiromi, Hama, Natsuko, Sakai, Ryuichi, Ushijima, Toshikazu, Matsutani, Masao, Shibata, Tatsuhiro, Nishikawa, Ryo, and The Intracranial Germ Cell Tumor Genome Analysis Consortium
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- 2016
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35. Comprehensive Genomic Profiling of Neuroendocrine Carcinomas of the Gastrointestinal System
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Pathologie Groep Brosens, Cancer, Pathologie Pathologen staf, Yachida, Shinichi, Totoki, Yasushi, Noe, Michael, Nakatani, Yoichiro, Horie, Masafumi, Kawasaki, Kenta, Nakamura, Hiromi, Saito-Adachi, Mihoko, Suzuki, Masami, Takai, Erina, Hama, Natsuko, Higuchi, Ryota, Hirono, Seiko, Shiba, Satoshi, Kato, Mamoru, Furukawa, Eisaku, Arai, Yasuhito, Rokutan, Hirofumi, Hashimoto, Taiki, Mitsunaga, Shuichi, Kanda, Mitsuro, Tanaka, Hidenori, Takata, So, Shimomura, Ayaka, Oshima, Minoru, Hackeng, Wenzel M, Okumura, Tomoyuki, Okano, Keiichi, Yamamoto, Masakazu, Yamaue, Hiroki, Morizane, Chigusa, Arihiro, Koji, Furukawa, Toru, Sato, Toshiro, Kiyono, Tohru, Brosens, Lodewijk A A, Wood, Laura D, Hruban, Ralph H, Shibata, Tatsuhiro, Pathologie Groep Brosens, Cancer, Pathologie Pathologen staf, Yachida, Shinichi, Totoki, Yasushi, Noe, Michael, Nakatani, Yoichiro, Horie, Masafumi, Kawasaki, Kenta, Nakamura, Hiromi, Saito-Adachi, Mihoko, Suzuki, Masami, Takai, Erina, Hama, Natsuko, Higuchi, Ryota, Hirono, Seiko, Shiba, Satoshi, Kato, Mamoru, Furukawa, Eisaku, Arai, Yasuhito, Rokutan, Hirofumi, Hashimoto, Taiki, Mitsunaga, Shuichi, Kanda, Mitsuro, Tanaka, Hidenori, Takata, So, Shimomura, Ayaka, Oshima, Minoru, Hackeng, Wenzel M, Okumura, Tomoyuki, Okano, Keiichi, Yamamoto, Masakazu, Yamaue, Hiroki, Morizane, Chigusa, Arihiro, Koji, Furukawa, Toru, Sato, Toshiro, Kiyono, Tohru, Brosens, Lodewijk A A, Wood, Laura D, Hruban, Ralph H, and Shibata, Tatsuhiro
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- 2022
36. Genomic spectra of biliary tract cancer
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Nakamura, Hiromi, Arai, Yasuhito, Totoki, Yasushi, Shirota, Tomoki, Elzawahry, Asmaa, Kato, Mamoru, Hama, Natsuko, Hosoda, Fumie, Urushidate, Tomoko, Ohashi, Shoko, Hiraoka, Nobuyoshi, Ojima, Hidenori, Shimada, Kazuaki, Okusaka, Takuji, Kosuge, Tomoo, Miyagawa, Shinichi, and Shibata, Tatsuhiro
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- 2015
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37. Genomic landscape of chemical-induced lung tumors under Nrf2 different expression levels
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Satoh, Hironori, primary, Arai, Yasuhito, additional, Furukawa, Eisaku, additional, Moriguchi, Takashi, additional, Hama, Natsuko, additional, Urushidate, Tomoko, additional, Totoki, Yasushi, additional, Kato, Mamoru, additional, Ohe, Yuichiro, additional, Yamamoto, Masayuki, additional, and Shibata, Tatsuhiro, additional
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- 2022
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38. Comprehensive Genomic Profiling of Neuroendocrine Carcinomas of the Gastrointestinal System
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Yachida, Shinichi, primary, Totoki, Yasushi, additional, Noë, Michaël, additional, Nakatani, Yoichiro, additional, Horie, Masafumi, additional, Kawasaki, Kenta, additional, Nakamura, Hiromi, additional, Saito-Adachi, Mihoko, additional, Suzuki, Masami, additional, Takai, Erina, additional, Hama, Natsuko, additional, Higuchi, Ryota, additional, Hirono, Seiko, additional, Shiba, Satoshi, additional, Kato, Mamoru, additional, Furukawa, Eisaku, additional, Arai, Yasuhito, additional, Rokutan, Hirofumi, additional, Hashimoto, Taiki, additional, Mitsunaga, Shuichi, additional, Kanda, Mitsuro, additional, Tanaka, Hidenori, additional, Takata, So, additional, Shimomura, Ayaka, additional, Oshima, Minoru, additional, Hackeng, Wenzel M., additional, Okumura, Tomoyuki, additional, Okano, Keiichi, additional, Yamamoto, Masakazu, additional, Yamaue, Hiroki, additional, Morizane, Chigusa, additional, Arihiro, Koji, additional, Furukawa, Toru, additional, Sato, Toshiro, additional, Kiyono, Tohru, additional, Brosens, Lodewijk A.A., additional, Wood, Laura D., additional, Hruban, Ralph H., additional, and Shibata, Tatsuhiro, additional
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- 2022
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39. Role for piRNAs and Noncoding RNA in de Novo DNA Methylation of the Imprinted Mouse Rasgrf1 Locus
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Watanabe, Toshiaki, Tomizawa, Shin-ichi, Mitsuya, Kohzoh, Totoki, Yasushi, Yamamoto, Yasuhiro, Kuramochi-Miyagawa, Satomi, Iida, Naoka, Hoki, Yuko, Murphy, Patrick J., Toyoda, Atsushi, Gotoh, Kengo, Hiura, Hitoshi, Arima, Takahiro, Fujiyama, Asao, Sado, Takashi, Shibata, Tatsuhiro, Nakano, Toru, Lin, Haifan, Ichiyanagi, Kenji, Soloway, Paul D., and Sasaki, Hiroyuki
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- 2011
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40. Transcriptome and methylome analysis of CNS germ cell tumor finds its cell-of-origin in embryogenesis and reveals shared similarities with testicular counterparts
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Takami, Hirokazu, primary, Elzawahry, Asmaa, additional, Mamatjan, Yasin, additional, Fukushima, Shintaro, additional, Fukuoka, Kohei, additional, Suzuki, Tomonari, additional, Yanagisawa, Takaaki, additional, Matsushita, Yuko, additional, Nakamura, Taishi, additional, Satomi, Kaishi, additional, Tanaka, Shota, additional, Mukasa, Akitake, additional, Saito, Nobuhito, additional, Kanamori, Masayuki, additional, Kumabe, Toshihiro, additional, Tominaga, Teiji, additional, Kobayashi, Keiichi, additional, Nagane, Motoo, additional, Iuchi, Toshihiko, additional, Tamura, Kaoru, additional, Maehara, Taketoshi, additional, Sugiyama, Kazuhiko, additional, Yoshimoto, Koji, additional, Sakai, Keiichi, additional, Nonaka, Masahiro, additional, Asai, Akio, additional, Yokogami, Kiyotaka, additional, Takeshima, Hideo, additional, Narita, Yoshitaka, additional, Shibui, Soichiro, additional, Nakazato, Yoichi, additional, Hama, Natsuko, additional, Totoki, Yasushi, additional, Kato, Mamoru, additional, Shibata, Tatsuhiro, additional, Nishikawa, Ryo, additional, Matsutani, Masao, additional, and Ichimura, Koichi, additional
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- 2022
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41. Clonal dynamics of circulating tumor DNA during immune checkpoint blockade therapy for melanoma
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Takai, Erina, primary, Omata, Wataru, additional, Totoki, Yasushi, additional, Nakamura, Hiromi, additional, Shiba, Satoshi, additional, Takahashi, Akira, additional, Namikawa, Kenjiro, additional, Mori, Taisuke, additional, Yamazaki, Naoya, additional, Shibata, Tatsuhiro, additional, and Yachida, Shinichi, additional
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- 2021
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42. Expression and clinical significance of genes frequently mutated in small cell lung cancers defined by whole exome/RNA sequencing
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Iwakawa, Reika, Kohno, Takashi, Totoki, Yasushi, Shibata, Tatsuhiro, Tsuchihara, Katsuya, Mimaki, Sachiyo, Tsuta, Koji, Narita, Yoshitaka, Nishikawa, Ryo, Noguchi, Masayuki, Harris, Curtis C., Robles, Ana I., Yamaguchi, Rui, Imoto, Seiya, Miyano, Satoru, Totsuka, Hirohiko, Yoshida, Teruhiko, and Yokota, Jun
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- 2015
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43. Active role of small non-coding RNAs derived from SINE/B1 retrotransposon during early mouse development
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Ohnishi, Yusuke, Totoki, Yasushi, Toyoda, Atsushi, Watanabe, Toshiaki, Yamamoto, Yasuhiro, Tokunaga, Katsushi, Sakaki, Yoshiyuki, Sasaki, Hiroyuki, and Hohjoh, Hirohiko
- Published
- 2012
- Full Text
- View/download PDF
44. Fibroblast growth factor receptor 2 tyrosine kinase fusions define a unique molecular subtype of cholangiocarcinoma
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Arai, Yasuhito, Totoki, Yasushi, Hosoda, Fumie, Shirota, Tomoki, Hama, Natsuko, Nakamura, Hiromi, Ojima, Hidenori, Furuta, Koh, Shimada, Kazuaki, Okusaka, Takuji, Kosuge, Tomoo, and Shibata, Tatsuhiro
- Published
- 2014
- Full Text
- View/download PDF
45. Endogenous siRNAs from naturally formed dsRNAs regulate transcripts in mouse oocytes
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Watanabe, Toshiaki, Totoki, Yasushi, Toyoda, Atsushi, Kaneda, Masahiro, Kuramochi-Miyagawa, Satomi, Obata, Yayoi, Chiba, Hatsune, Kohara, Yuji, Kono, Tomohiro, Nakano, Toru, Surani, M. Azim, Sakaki, Yoshiyuki, and Sasaki, Hiroyuki
- Subjects
Oocytes -- Genetic aspects -- Research ,RNA -- Properties -- Research -- Genetic aspects ,Mice -- Genetic aspects -- Research ,Environmental issues ,Science and technology ,Zoology and wildlife conservation ,Genetic aspects ,Research ,Properties - Abstract
RNA interference (RNAi) is a mechanism by which double-stranded RNAs (dsRNAs) suppress specific transcripts in a sequence-dependent manner. dsRNAs are processed by Dicer to 21-24-nucleotide small interfering RNAs (siRNAs) and [...]
- Published
- 2008
46. Pan-cancer analysis of whole genomes
- Author
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Campbell, Peter J., Getz, Gad, Korbel, Jan O., Stuart, Joshua M., Jennings, Jennifer L., Stein, Lincoln D., Perry, Marc D., Nahal-Bose, Hardeep K., Ouellette, B. F. Francis, Li, Constance H., Rheinbay, Esther, Nielsen, G. Petur, Sgroi, Dennis C., Wu, Chin-Lee, Faquin, William C., Deshpande, Vikram, Boutros, Paul C., Lazar, Alexander J., Hoadley, Katherine A., Louis, David N., Dursi, L. Jonathan, Yung, Christina K., Bailey, Matthew H., Saksena, Gordon, Raine, Keiran M., Buchhalter, Ivo, Kleinheinz, Kortine, Schlesner, Matthias, Zhang, Junjun, Wang, Wenyi, Wheeler, David A., Ding, Li, Simpson, Jared T., O'Connor, Brian D., Yakneen, Sergei, Ellrott, Kyle, Miyoshi, Naoki, Butler, Adam P., Royo, Romina, Shorser, Solomon, I, Vazquez, Miguel, Rausch, Tobias, Tiao, Grace, Waszak, Sebastian M., Rodriguez-Martin, Bernardo, Shringarpure, Suyash, Wu, Dai-Ying, Demidov, German M., Delaneau, Olivier, Hayashi, Shuto, Imoto, Seiya, Habermann, Nina, Segre, Ayellet, V, Garrison, Erik, Cafferkey, Andy, Alvarez, Eva G., Maria Heredia-Genestar, Jose, Muyas, Francesc, Drechsel, Oliver, Bruzos, Alicia L., Temes, Javier, Zamora, Jorge, Baez-Ortega, Adrian, Kim, Hyung-Lae, Mashl, R. 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C., De La Vega, Francisco M., Estivill, Xavier, Yuen, Denis, Mihaiescu, George L., Omberg, Larsson, Ferretti, Vincent, Sabarinathan, Radhakrishnan, Pich, Oriol, Gonzalez-Perez, Abel, Weiner, Amaro Taylor, Fittall, Matthew W., Demeulemeester, Jonas, Tarabichi, Maxime, Roberts, Nicola D., Van Loo, Peter, Cortes-Ciriano, Isidro, Urban, Lara, Park, Peter, Pitkaenen, Esa, Li, Yilong, Saini, Natalie, Klimczak, Leszek J., Weischenfeldt, Joachim, Sidiropoulos, Nikos, Alexandrov, Ludmil B., Rabionet, Raquel, Escaramis, Georgia, Bosio, Mattia, Holik, Aliaksei Z., Susak, Hana, Prasad, Aparna, Erkek, Serap, Calabrese, Claudia, Raeder, Benjamin, Harrington, Eoghan, Mayes, Simon, Turner, Daniel, Juul, Sissel, Roberts, Steven A., Song, Lei, Koster, Roelof, Mirabello, Lisa, Hua, Xing, Tanskanen, Tomas J., Tojo, Marta, Chen, Jieming, Aaltonen, Lauri A., Ratsch, Gunnar, Schwarz, Roland F., Butte, Atul J., Brazma, Alvis, Chanock, Stephen J., Chatterjee, Nilanjan, Stegle, Oliver, Harismendy, Olivier, Bova, G. Steven, Gordenin, Dmitry A., Haan, David, Sieverling, Lina, Feuerbach, Lars, Chalmers, Don, Joly, Yann, Knoppers, Bartha, Molnar-Gabor, Fruzsina, Phillips, Mark, Thorogood, Adrian, Townend, David, Goldman, Mary, Fonseca, Nuno A., Xiang, Qian, Craft, Brian, Pineiro-Yanez, Elena, Munoz, Alfonso, Petryszak, Robert, Fullgrabe, Anja, Al-Shahrour, Fatima, Keays, Maria, Haussler, David, Weinstein, John, Huber, Wolfgang, Valencia, Alfonso, Papatheodorou, Irene, Zhu, Jingchun, Fan, Yu, Torrents, David, Bieg, Matthias, Chen, Ken, Chong, Zechen, Cibulskis, Kristian, Eils, Roland, Fulton, Robert S., Gelpi, Josep L., Gonzalez, Santiago, Gut, Ivo G., Hach, Faraz, Heinold, Michael, Hu, Taobo, Huang, Vincent, Hutter, Barbara, Jaeger, Natalie, Jung, Jongsun, Kumar, Yogesh, Lalansingh, Christopher, Leshchiner, Ignaty, Livitz, Dimitri, Ma, Eric Z., Maruvka, Yosef E., Milovanovic, Ana, Nielsen, Morten Muhlig, Paramasivam, Nagarajan, Pedersen, Jakob Skou, Puiggros, Montserrat, Sahinalp, S. Cenk, Sarrafi, Iman, Stewart, Chip, Stobbe, Miranda D., Wala, Jeremiah A., Wang, Jiayin, Wendl, Michael, Werner, Johannes, Wu, Zhenggang, Xue, Hong, Yamaguchi, Takafumi N., Yellapantula, Venkata, Davis-Dusenbery, Brandi N., Grossman, Robert L., Kim, Youngwook, Heinold, Michael C., Hinton, Jonathan, Jones, David R., Menzies, Andrew, Stebbings, Lucy, Hess, Julian M., Rosenberg, Mara, Dunford, Andrew J., Gupta, Manaswi, Imielinski, Marcin, Meyerson, Matthew, Beroukhim, Rameen, Reimand, Juri, Dhingra, Priyanka, Favero, Francesco, Dentro, Stefan, Wintersinger, Jeff, Rudneva, Vasilisa, Park, Ji Wan, Hong, Eun Pyo, Heo, Seong Gu, Kahles, Andre, Soulette, Cameron M., Shiraishi, Yuichi, Liu, Fenglin, He, Yao, Demircioglu, Deniz, Davidson, Natalie R., Greger, Liliana, Li, Siliang, Liu, Dongbing, Stark, Stefan G., Zhang, Fan, Amin, Samirkumar B., Bailey, Peter, Chateigner, Aurelien, Frenkel-Morgenstern, Milana, Hou, Yong, Huska, Matthew R., Kilpinen, Helena, Lamaze, Fabien C., Li, Chang, Li, Xiaobo, Li, Xinyue, Liu, Xingmin, Marin, Maximillian G., Markowski, Julia, Nandi, Tannistha, Ojesina, Akinyemi, I, Pan-Hammarstrom, Qiang, Park, Peter J., Pedamallu, Chandra Sekhar, Su, Hong, Tan, Patrick, Teh, Bin Tean, Wang, Jian, Xiong, Heng, Ye, Chen, Yung, Christina, Zhang, Xiuqing, Zheng, Liangtao, Zhu, Shida, Awadalla, Philip, Creighton, Chad J., Wu, Kui, Yang, Huanming, Goke, Jonathan, Zhang, Zemin, Brooks, Angela N., Martincorena, Inigo, Rubio-Perez, Carlota, Juul, Malene, Schumacher, Steven, Shapira, Ofer, Tamborero, David, Mularoni, Loris, Hornshoj, Henrik, Deu-Pons, Jordi, Muinos, Ferran, Bertl, Johanna, Guo, Qianyun, Bazant, Wojciech, Barrera, Elisabet, Al-Sedairy, Sultan T., Aretz, Axel, Bell, Cindy, Betancourt, Miguel, Buchholz, Christiane, Calvo, Fabien, Chomienne, Christine, Dunn, Michael, Edmonds, Stuart, Green, Eric, Gupta, Shailja, Hutter, Carolyn M., Jegalian, Karine, Jones, Nic, Lu, Youyong, Nakagama, Hitoshi, Nettekoven, Gerd, Planko, Laura, Scott, David, Shibata, Tatsuhiro, Shimizu, Kiyo, Stratton, Michael R., Yugawa, Takashi, Tortora, Giampaolo, VijayRaghavan, K., Zenklusen, Jean C., Knoppers, Bartha M., Aminou, Brice, Bartolome, Javier, Boroevich, Keith A., Boyce, Rich, Buchanan, Alex, Byrne, Niall J., Chen, Zhaohong, Cho, Sunghoon, Choi, Wan, Clapham, Peter, Dow, Michelle T., Dursi, Lewis Jonathan, Eils, Juergen, Farcas, Claudiu, Fayzullaev, Nodirjon, Flicek, Paul, Heath, Allison P., Hofmann, Oliver, Hong, Jongwhi H., Hudson, Thomas J., Huebschmann, Daniel, Ivkovic, Sinisa, Jeon, Seung-Hyup, Jiao, Wei, Kabbe, Rolf, Kerssemakers, Jules N. 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G., Gao, Shengjie, Huang, Yi, Lalansingh, Christopher M., Teague, Jon W., Wendl, Michael C., Abascal, Federico, Bader, Gary D., Bandopadhayay, Pratiti, Barenboim, Jonathan, Brunak, Soren, Fita, Joana Carlevaro, Chakravarty, Dimple, Chan, Calvin Wing Yiu, Choi, Jung Kyoon, Diamanti, Klev, Fink, J. Lynn, Frigola, Joan, Gambacorti-Passerini, Carlo, Garsed, Dale W., Haradhvala, Nicholas J., Harmanci, Arif O., Helmy, Mohamed, Herrmann, Carl, Hobolth, Asger, Hodzic, Ermin, Hong, Chen, Isaev, Keren, Izarzugaza, Jose M. 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P., Pearson, John, V, Rippe, Karsten, Scully, Ralph, Villasante, Izar, Waddell, Nicola, Yang, Lixing, Yao, Xiaotong, Yoon, Sung-Soo, Zhang, Cheng-Zhong, Bergstrom, Erik N., Boot, Arnoud, Covington, Kyle, Fujimoto, Akihiro, Huang, Mi Ni, Islam, S. M. 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C., Christ, Angelika N., Cordner, Stephen M., Cowin, Prue A., Drapkin, Ronny, Fereday, Sian, George, Joshy, Hamilton, Anne, Holmes, Oliver, Hung, Jillian A., Kassahn, Karin S., Kazakoff, Stephen H., Kennedy, Catherine J., Leonard, Conrad R., Mileshkin, Linda, Miller, David K., Arnau, Gisela Mir, Mitchell, Chris, Newell, Felicity, Nones, Katia, Patch, Ann-Marie, Quinn, Michael C., Taylor, Darrin F., Thorne, Heather, Traficante, Nadia, Vedururu, Ravikiran, Waddell, Nick M., Waring, Paul M., Wood, Scott, Xu, Qinying, DeFazio, Anna, Anderson, Matthew J., Antonello, Davide, Barbour, Andrew P., Bassi, Claudio, Bersani, Samantha, Cataldo, Ivana, Chantrill, Lorraine A., Chiew, Yoke-Eng, Chou, Angela, Cingarlini, Sara, Cloonan, Nicole, Corbo, Vincenzo, Davi, Maria Vittoria, Duthie, Fraser R., Gill, Anthony J., Graham, Janet S., Harliwong, Ivon, Jamieson, Nigel B., Johns, Amber L., Kench, James G., Landoni, Luca, Lawlor, Rita T., Mafficini, Andrea, Merrett, Neil D., Miotto, Marco, Musgrove, Elizabeth A., Nagrial, Adnan M., Oien, Karin A., Pajic, Marina, Pinese, Mark, Robertson, Alan J., Rooman, Ilse, Rusev, Borislav C., Samra, Jaswinder S., Scardoni, Maria, Scarlett, Christopher J., Scarpa, Aldo, Sereni, Elisabetta, Sikora, Katarzyna O., Simbolo, Michele, Taschuk, Morgan L., Toon, Christopher W., Vicentini, Caterina, Wu, Jianmin, Zeps, Nikolajs, Behren, Andreas, Burke, Hazel, Cebon, Jonathan, Dagg, Rebecca A., De Paoli-Iseppi, Ricardo, Dutton-Regester, Ken, Field, Matthew A., Fitzgerald, Anna, Hersey, Peter, Jakrot, Valerie, Johansson, Peter A., Kakavand, Hojabr, Kefford, Richard F., Lau, Loretta M. 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A., Sam, Michelle, Selander, Iris, Serra, Stefano, Shahabi, Sagedeh, Thayer, Sarah P., Timms, Lee E., Wilson, Gavin W., Wilson, Julie M., Wouters, Bradly G., McPherson, John D., Beck, Timothy A., Bhandari, Vinayak, Collins, Colin C., Fleshner, Neil E., Fox, Natalie S., Fraser, Michael, Heisler, Lawrence E., Lalonde, Emilie, Livingstone, Julie, Meng, Alice, Sabelnykova, Veronica Y., Shiah, Yu-Jia, Van Der Kwast, Theodorus, Bristow, Robert G., Ding, Shuai, Fan, Daiming, Li, Lin, Nie, Yongzhan, Xiao, Xiao, Xing, Rui, Yang, Shanlin, Yu, Yingyan, Zhou, Yong, Banks, Rosamonde E., Bourque, Guillaume, Brennan, Paul, Letourneau, Louis, Riazalhosseini, Yasser, Scelo, Ghislaine, Vasudev, Naveen, Viksna, Juris, Lathrop, Mark, Tost, Jorg, Ahn, Sung-Min, Aparicio, Samuel, Arnould, Laurent, Aure, M. 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M., van de Vijver, Marc J., van't Veer, Laura, Ammerpohl, Ole, Aukema, Sietse, Bergmann, Anke K., Bernhart, Stephan H., Borkhardt, Arndt, Borst, Christoph, Burkhardt, Birgit, Claviez, Alexander, Goebler, Maria Elisabeth, Haake, Andrea, Haas, Siegfried, Hansmann, Martin, Hoell, Jessica, I, Hummel, Michael, Karsch, Dennis, Klapper, Wolfram, Kneba, Michael, Kreuz, Markus, Kube, Dieter, Kueppers, Ralf, Lenze, Dido, Loeffler, Markus, Lopez, Cristina, Mantovani-Loeffler, Luisa, Moeller, Peter, Ott, German, Radlwimmer, Bernhard, Richter, Julia, Rohde, Marius, Rosenstiel, Philip C., Rosenwald, Andreas, Schilhabel, Markus B., Schreiber, Stefan, Stadler, Peter F., Staib, Peter, Stilgenbauer, Stephan, Sungalee, Stephanie, Szczepanowski, Monika, Toprak, Umut H., Truemper, Lorenz H. 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A., Myklebost, Ola, Pillay, Nischalan, Tarpey, Patrick, Tirabosco, Roberto, Zaikova, Olga, Flanagan, Adrienne M., Boultwood, Jacqueline, Bowen, David T., Cazzola, Mario, Green, Anthony R., Hellstrom-Lindberg, Eva, Malcovati, Luca, Nangalia, Jyoti, Papaemmanuil, Elli, Vyas, Paresh, Ang, Yeng, Barr, Hugh, Beardsmore, Duncan, Eldridge, Matthew, Gossage, James, Grehan, Nicola, Hanna, George B., Hayes, Stephen J., Hupp, Ted R., Khoo, David, Lagergren, Jesper, Lovat, Laurence B., MacRae, Shona, O'Donovan, Maria, O'Neill, J. Robert, Parsons, Simon L., Preston, Shaun R., Puig, Sonia, Roques, Tom, Sanders, Grant, Sothi, Sharmila, Tavare, Simon, Tucker, Olga, Turkington, Richard, Underwood, Timothy J., Welch, Ian, Fitzgerald, Rebecca C., Berney, Daniel M., De Bono, Johann S., Cahill, Declan, Camacho, Niedzica, Dennis, Nening M., Dudderidge, Tim, Edwards, Sandra E., Fisher, Cyril, Foster, Christopher S., Ghori, Mohammed, Gill, Pelvender, Gnanapragasam, Vincent J., Gundem, Gunes, Hamdy, Freddie C., Hawkins, Steve, Hazell, Steven, Howat, William, Isaacs, William B., Karaszi, Katalin, Kay, Jonathan D., Khoo, Vincent, Kote-Jarai, Zsofia, Kremeyer, Barbara, Kumar, Pardeep, Lambert, Adam, Leongamornlert, Daniel A., Livni, Naomi, Lu, Yong-Jie, Luxton, Hayley J., Marsden, Luke, Massie, Charlie E., Matthews, Lucy, Mayer, Erik, McDermott, Ultan, Merson, Sue, Neal, David E., Ng, Anthony, Nicol, David, Ogden, Christopher, Rowe, Edward W., Shah, Nimish C., Thomas, Sarah, Thompson, Alan, Verrill, Clare, Visakorpi, Tapio, Warren, Anne Y., Whitaker, Hayley C., Zhang, Hongwei, van As, Nicholas, Eeles, Rosalind A., Abeshouse, Adam, Agrawal, Nishant, Akbani, Rehan, Al Ahmadie, Hikmat, Albert, Monique, Aldape, Kenneth, Ally, Adrian, Appelbaum, Elizabeth L., Armenia, Joshua, Asa, Sylvia, Auman, J. Todd, Balasundaram, Miruna, Balu, Saianand, Barnholtz-Sloan, Jill, Bathe, Oliver F., Baylin, Stephen B., Benz, Christopher, Berchuck, Andrew, Berrios, Mario, Bigner, Darell, Birrer, Michael, Bodenheimer, Tom, Boice, Lori, Bootwalla, Moiz S., Bosenberg, Marcus, Bowlby, Reanne, Boyd, Jeffrey, Broaddus, Russell R., Brock, Malcolm, Brooks, Denise, Bullman, Susan, Caesar-Johnson, Samantha J., Carey, Thomas E., Carlsen, Rebecca, Cerfolio, Robert, Chandan, Vishal S., Chen, Hsiao-Wei, Cherniack, Andrew D., Chien, Jeremy, Cho, Juok, Chuah, Eric, Cibulskis, Carrie, Cope, Leslie, Cordes, Matthew G., Curley, Erin, Czerniak, Bogdan, Danilova, Ludmila, Davis, Ian J., Defreitas, Timothy, Demchok, John A., Dhalla, Noreen, Dhir, Rajiv, Doddapaneni, HarshaVardhan, El-Naggar, Adel, Felau, Ina, Ferguson, Martin L., Finocchiaro, Gaetano, Fong, Kwun M., Frazer, Scott, Friedman, William, Fronick, Catrina C., Fulton, Lucinda A., Gabriel, Stacey B., Gao, Jianjiong, Gehlenborg, Nils, Gershenwald, Jeffrey E., Ghossein, Ronald, Giama, Nasra H., Gibbs, Richard A., Gomez, Carmen, Govindan, Ramaswamy, Hayes, D. Neil, Hegde, Apurva M., Heiman, David, I, Heins, Zachary, Hepperla, Austin J., Holbrook, Andrea, Holt, Robert A., Hoyle, Alan P., Hruban, Ralph H., Hu, Jianhong, Huang, Mei, Huntsman, David, Huse, Jason, Donahue, Christine A. Iacobuzio, Ittmann, Michael, Jayaseelan, Joy C., Jefferys, Stuart R., Jones, Corbin D., Jones, Steven J. M., Juhl, Hartmut, Kang, Koo Jeong, Karlan, Beth, Kasaian, Katayoon, Kebebew, Electron, Kim, Hark Kyun, Korchina, Viktoriya, Kundra, Ritika, Lai, Phillip H., Lander, Eric, Le, Xuan, Lee, Darlene, Levine, Douglas A., Lewis, Lora, Ley, Tim, Li, Haiyan Irene, Lin, Pei, Linehan, W. M., Liu, Fei Fei, Lu, Yiling, Lype, Lisa, Ma, Yussanne, Maglinte, Dennis T., Mardis, Elaine R., Marks, Jeffrey, Marra, Marco A., Matthew, Thomas J., Mayo, Michael, McCune, Karen, Meier, Samuel R., Meng, Shaowu, Mieczkowski, Piotr A., Mikkelsen, Tom, Miller, Christopher A., Mills, Gordon B., Moore, Richard A., Morrison, Carl, Mose, Lisle E., Moser, Catherine D., Mungall, Andrew J., Mungall, Karen, Mutch, David, Muzny, Donna M., Myers, Jerome, Newton, Yulia, Noble, Michael S., O'Donnell, Peter, O'Neill, Brian Patrick, Ochoa, Angelica, Park, Joong-Won, Parker, Joel S., Pass, Harvey, Pastore, Alessandro, Pennell, Nathan A., Perou, Charles M., Petrelli, Nicholas, Potapova, Olga, Rader, Janet S., Ramalingam, Suresh, Rathmell, W. Kimryn, Reuter, Victor, Reynolds, Sheila M., Ringel, Matthew, Roach, Jeffrey, Roberts, Lewis R., Robertson, A. Gordon, Sadeghi, Sara, Saller, Charles, Sanchez-Vega, Francisco, Schadendorf, Dirk, Schein, Jacqueline E., Schmidt, Heather K., Schultz, Nikolaus, Seethala, Raja, Senbabaoglu, Yasin, Shelton, Troy, Shi, Yan, Shih, Juliann, Shmulevich, Ilya, Shriver, Craig, Signoretti, Sabina, Simons, Janae, V, Singer, Samuel, Sipahimalani, Payal, Skelly, Tara J., McCune, Karen Smith, Socci, Nicholas D., Soloway, Matthew G., Sood, Anil K., Tam, Angela, Tan, Donghui, Tarnuzzer, Roy, Thiessen, Nina, Thompson, R. Houston, Thorne, Leigh B., Tsao, Ming, Umbricht, Christopher, Van Den Berg, David J., Van Meir, Erwin G., Veluvolu, Umadevi, Voet, Douglas, Wang, Linghua, Weinberger, Paul, Weisenberger, Daniel J., Wigle, Dennis, Wilkerson, Matthew D., Wilson, Richard K., Winterhoff, Boris, Wiznerowicz, Maciej, Wong, Tina, Wong, Winghing, Xi, Liu, Yau, Christina, Zhang, Hailei, Zhang, Hongxin, Zhang, Jiashan, Campbell, Peter J., Getz, Gad, Korbel, Jan O., Stuart, Joshua M., Jennings, Jennifer L., Stein, Lincoln D., Perry, Marc D., Nahal-Bose, Hardeep K., Ouellette, B. F. Francis, Li, Constance H., Rheinbay, Esther, Nielsen, G. Petur, Sgroi, Dennis C., Wu, Chin-Lee, Faquin, William C., Deshpande, Vikram, Boutros, Paul C., Lazar, Alexander J., Hoadley, Katherine A., Louis, David N., Dursi, L. Jonathan, Yung, Christina K., Bailey, Matthew H., Saksena, Gordon, Raine, Keiran M., Buchhalter, Ivo, Kleinheinz, Kortine, Schlesner, Matthias, Zhang, Junjun, Wang, Wenyi, Wheeler, David A., Ding, Li, Simpson, Jared T., O'Connor, Brian D., Yakneen, Sergei, Ellrott, Kyle, Miyoshi, Naoki, Butler, Adam P., Royo, Romina, Shorser, Solomon, I, Vazquez, Miguel, Rausch, Tobias, Tiao, Grace, Waszak, Sebastian M., Rodriguez-Martin, Bernardo, Shringarpure, Suyash, Wu, Dai-Ying, Demidov, German M., Delaneau, Olivier, Hayashi, Shuto, Imoto, Seiya, Habermann, Nina, Segre, Ayellet, V, Garrison, Erik, Cafferkey, Andy, Alvarez, Eva G., Maria Heredia-Genestar, Jose, Muyas, Francesc, Drechsel, Oliver, Bruzos, Alicia L., Temes, Javier, Zamora, Jorge, Baez-Ortega, Adrian, Kim, Hyung-Lae, Mashl, R. Jay, Ye, Kai, DiBiase, Anthony, Huang, Kuan-lin, Letunic, Ivica, McLellan, Michael D., Newhouse, Steven J., Shmaya, Tal, Kumar, Sushant, Wedge, David C., Wright, Mark H., Yellapantula, Venkata D., Gerstein, Mark, Khurana, Ekta, Marques-Bonet, Tomas, Navarro, Arcadi, Bustamante, Carlos D., Siebert, Reiner, Nakagawa, Hidewaki, Easton, Douglas F., Ossowski, Stephan, Tubio, Jose M. C., De La Vega, Francisco M., Estivill, Xavier, Yuen, Denis, Mihaiescu, George L., Omberg, Larsson, Ferretti, Vincent, Sabarinathan, Radhakrishnan, Pich, Oriol, Gonzalez-Perez, Abel, Weiner, Amaro Taylor, Fittall, Matthew W., Demeulemeester, Jonas, Tarabichi, Maxime, Roberts, Nicola D., Van Loo, Peter, Cortes-Ciriano, Isidro, Urban, Lara, Park, Peter, Pitkaenen, Esa, Li, Yilong, Saini, Natalie, Klimczak, Leszek J., Weischenfeldt, Joachim, Sidiropoulos, Nikos, Alexandrov, Ludmil B., Rabionet, Raquel, Escaramis, Georgia, Bosio, Mattia, Holik, Aliaksei Z., Susak, Hana, Prasad, Aparna, Erkek, Serap, Calabrese, Claudia, Raeder, Benjamin, Harrington, Eoghan, Mayes, Simon, Turner, Daniel, Juul, Sissel, Roberts, Steven A., Song, Lei, Koster, Roelof, Mirabello, Lisa, Hua, Xing, Tanskanen, Tomas J., Tojo, Marta, Chen, Jieming, Aaltonen, Lauri A., Ratsch, Gunnar, Schwarz, Roland F., Butte, Atul J., Brazma, Alvis, Chanock, Stephen J., Chatterjee, Nilanjan, Stegle, Oliver, Harismendy, Olivier, Bova, G. Steven, Gordenin, Dmitry A., Haan, David, Sieverling, Lina, Feuerbach, Lars, Chalmers, Don, Joly, Yann, Knoppers, Bartha, Molnar-Gabor, Fruzsina, Phillips, Mark, Thorogood, Adrian, Townend, David, Goldman, Mary, Fonseca, Nuno A., Xiang, Qian, Craft, Brian, Pineiro-Yanez, Elena, Munoz, Alfonso, Petryszak, Robert, Fullgrabe, Anja, Al-Shahrour, Fatima, Keays, Maria, Haussler, David, Weinstein, John, Huber, Wolfgang, Valencia, Alfonso, Papatheodorou, Irene, Zhu, Jingchun, Fan, Yu, Torrents, David, Bieg, Matthias, Chen, Ken, Chong, Zechen, Cibulskis, Kristian, Eils, Roland, Fulton, Robert S., Gelpi, Josep L., Gonzalez, Santiago, Gut, Ivo G., Hach, Faraz, Heinold, Michael, Hu, Taobo, Huang, Vincent, Hutter, Barbara, Jaeger, Natalie, Jung, Jongsun, Kumar, Yogesh, Lalansingh, Christopher, Leshchiner, Ignaty, Livitz, Dimitri, Ma, Eric Z., Maruvka, Yosef E., Milovanovic, Ana, Nielsen, Morten Muhlig, Paramasivam, Nagarajan, Pedersen, Jakob Skou, Puiggros, Montserrat, Sahinalp, S. Cenk, Sarrafi, Iman, Stewart, Chip, Stobbe, Miranda D., Wala, Jeremiah A., Wang, Jiayin, Wendl, Michael, Werner, Johannes, Wu, Zhenggang, Xue, Hong, Yamaguchi, Takafumi N., Yellapantula, Venkata, Davis-Dusenbery, Brandi N., Grossman, Robert L., Kim, Youngwook, Heinold, Michael C., Hinton, Jonathan, Jones, David R., Menzies, Andrew, Stebbings, Lucy, Hess, Julian M., Rosenberg, Mara, Dunford, Andrew J., Gupta, Manaswi, Imielinski, Marcin, Meyerson, Matthew, Beroukhim, Rameen, Reimand, Juri, Dhingra, Priyanka, Favero, Francesco, Dentro, Stefan, Wintersinger, Jeff, Rudneva, Vasilisa, Park, Ji Wan, Hong, Eun Pyo, Heo, Seong Gu, Kahles, Andre, Soulette, Cameron M., Shiraishi, Yuichi, Liu, Fenglin, He, Yao, Demircioglu, Deniz, Davidson, Natalie R., Greger, Liliana, Li, Siliang, Liu, Dongbing, Stark, Stefan G., Zhang, Fan, Amin, Samirkumar B., Bailey, Peter, Chateigner, Aurelien, Frenkel-Morgenstern, Milana, Hou, Yong, Huska, Matthew R., Kilpinen, Helena, Lamaze, Fabien C., Li, Chang, Li, Xiaobo, Li, Xinyue, Liu, Xingmin, Marin, Maximillian G., Markowski, Julia, Nandi, Tannistha, Ojesina, Akinyemi, I, Pan-Hammarstrom, Qiang, Park, Peter J., Pedamallu, Chandra Sekhar, Su, Hong, Tan, Patrick, Teh, Bin Tean, Wang, Jian, Xiong, Heng, Ye, Chen, Yung, Christina, Zhang, Xiuqing, Zheng, Liangtao, Zhu, Shida, Awadalla, Philip, Creighton, Chad J., Wu, Kui, Yang, Huanming, Goke, Jonathan, Zhang, Zemin, Brooks, Angela N., Martincorena, Inigo, Rubio-Perez, Carlota, Juul, Malene, Schumacher, Steven, Shapira, Ofer, Tamborero, David, Mularoni, Loris, Hornshoj, Henrik, Deu-Pons, Jordi, Muinos, Ferran, Bertl, Johanna, Guo, Qianyun, Bazant, Wojciech, Barrera, Elisabet, Al-Sedairy, Sultan T., Aretz, Axel, Bell, Cindy, Betancourt, Miguel, Buchholz, Christiane, Calvo, Fabien, Chomienne, Christine, Dunn, Michael, Edmonds, Stuart, Green, Eric, Gupta, Shailja, Hutter, Carolyn M., Jegalian, Karine, Jones, Nic, Lu, Youyong, Nakagama, Hitoshi, Nettekoven, Gerd, Planko, Laura, Scott, David, Shibata, Tatsuhiro, Shimizu, Kiyo, Stratton, Michael R., Yugawa, Takashi, Tortora, Giampaolo, VijayRaghavan, K., Zenklusen, Jean C., Knoppers, Bartha M., Aminou, Brice, Bartolome, Javier, Boroevich, Keith A., Boyce, Rich, Buchanan, Alex, Byrne, Niall J., Chen, Zhaohong, Cho, Sunghoon, Choi, Wan, Clapham, Peter, Dow, Michelle T., Dursi, Lewis Jonathan, Eils, Juergen, Farcas, Claudiu, Fayzullaev, Nodirjon, Flicek, Paul, Heath, Allison P., Hofmann, Oliver, Hong, Jongwhi H., Hudson, Thomas J., Huebschmann, Daniel, Ivkovic, Sinisa, Jeon, Seung-Hyup, Jiao, Wei, Kabbe, Rolf, Kerssemakers, Jules N. A., Kim, Hyunghwan, Kim, Jihoon, Koscher, Michael, Koures, Antonios, Kovacevic, Milena, Lawerenz, Chris, Liu, Jia, Mijalkovic, Sanja, Mijalkovic-Lazic, Ana Mijalkovic, Miyano, Satoru, Nastic, Mia, Nicholson, Jonathan, Ocana, David, Ohi, Kazuhiro, Ohno-Machado, Lucila, Pihl, Todd D., Prinz, Manuel, Radovic, Petar, Short, Charles, Sofia, Heidi J., Spring, Jonathan, Struck, Adam J., Tijanic, Nebojsa, Vicente, David, Wang, Zhining, Williams, Ashley, Woo, Youngchoon, Wright, Adam J., Yang, Liming, Hamilton, Mark P., Johnson, Todd A., Kahraman, Abdullah, Kellis, Manolis, Polak, Paz, Sallari, Richard, Sinnott-Armstrong, Nasa, von Mering, Christian, Beltran, Sergi, Gerhard, Daniela S., Gut, Marta, Trotta, Jean-Remi, Whalley, Justin P., Niu, Beifang, Espiritu, Shadrielle M. G., Gao, Shengjie, Huang, Yi, Lalansingh, Christopher M., Teague, Jon W., Wendl, Michael C., Abascal, Federico, Bader, Gary D., Bandopadhayay, Pratiti, Barenboim, Jonathan, Brunak, Soren, Fita, Joana Carlevaro, Chakravarty, Dimple, Chan, Calvin Wing Yiu, Choi, Jung Kyoon, Diamanti, Klev, Fink, J. Lynn, Frigola, Joan, Gambacorti-Passerini, Carlo, Garsed, Dale W., Haradhvala, Nicholas J., Harmanci, Arif O., Helmy, Mohamed, Herrmann, Carl, Hobolth, Asger, Hodzic, Ermin, Hong, Chen, Isaev, Keren, Izarzugaza, Jose M. G., Johnson, Rory, Juul, Randi Istrup, Kim, Jaegil, Kim, Jong K., Komorowski, Jan, Lanzos, Andres, Larsson, Erik, Lee, Donghoon, Li, Shantao, Li, Xiaotong, Lin, Ziao, Liu, Eric Minwei, Lochovsky, Lucas, Lou, Shaoke, Madsen, Tobias, Marchal, Kathleen, Fundichely, Alexander Martinez, McGillivray, Patrick D., Meyerson, William, Paczkowska, Marta, Park, Keunchil, Park, Kiejung, Pons, Tirso, Pulido-Tamayo, Sergio, Reyes Salazar, Iker, Reyna, Matthew A., Rubin, Mark A., Salichos, Leonidas, Sander, Chris, Schumacher, Steven E., Shackleton, Mark, Shen, Ciyue, Shrestha, Raunak, Shuai, Shimin, Tsunoda, Tatsuhiko, Umer, Husen M., Uuskula-Reimand, Liis, Verbeke, Lieven P. C., Wadelius, Claes, Wadi, Lina, Warrell, Jonathan, Wu, Guanming, Yu, Jun, Zhang, Jing, Zhang, Xuanping, Zhang, Yan, Zhao, Zhongming, Zou, Lihua, Lawrence, Michael S., Raphael, Benjamin J., Bailey, Peter J., Craft, David, Goldman, Mary J., Aburatani, Hiroyuki, Binder, Hans, Dinh, Huy Q., Heath, Simon C., Hoffmann, Steve, Imbusch, Charles David, Kretzmer, Helene, Laird, Peter W., Martin-Subero, Jose, I, Nagae, Genta, Shen, Hui, Wang, Qi, Weichenhan, Dieter, Zhou, Wanding, Berman, Benjamin P., Brors, Benedikt, Plass, Christoph, Akdemir, Kadir C., Bowtell, David D. L., Burns, Kathleen H., Busanovich, John, Chan, Kin, Dueso-Barroso, Ana, Edwards, Paul A., Etemadmoghadam, Dariush, Haber, James E., Jones, David T. W., Ju, Young Seok, Kazanov, Marat D., Koh, Youngil, Kumar, Kiran, Lee, Eunjung Alice, Lee, Jake June-Koo, Lynch, Andy G., Macintyre, Geoff, Markowetz, Florian, Navarro, Fabio C. P., Pearson, John, V, Rippe, Karsten, Scully, Ralph, Villasante, Izar, Waddell, Nicola, Yang, Lixing, Yao, Xiaotong, Yoon, Sung-Soo, Zhang, Cheng-Zhong, Bergstrom, Erik N., Boot, Arnoud, Covington, Kyle, Fujimoto, Akihiro, Huang, Mi Ni, Islam, S. M. Ashiqul, McPherson, John R., Morganella, Sandro, Mustonen, Ville, Ng, Alvin Wei Tian, Prokopec, Stephenie D., Vazquez-Garcia, Ignacio, Wu, Yang, Yousif, Fouad, Yu, Willie, Rozen, Steven G., Rudneva, Vasilisa A., Shringarpure, Suyash S., Turner, Daniel J., Xia, Tian, Atwal, Gurnit, Chang, David K., Cooke, Susanna L., Faltas, Bishoy M., Haider, Syed, Kaiser, Vera B., Karlic, Rosa, Kato, Mamoru, Kubler, Kirsten, Margolin, Adam, Martin, Sancha, Nik-Zainal, Serena, P'ng, Christine, Semple, Colin A., Smith, Jaclyn, Sun, Ren X., Thai, Kevin, Wright, Derek W., Yuan, Ke, Biankin, Andrew, V, Garraway, Levi, Grimmond, Sean M., Adams, David J., Anur, Pavana, Cao, Shaolong, Christie, Elizabeth L., Cmero, Marek, Cun, Yupeng, Dawson, Kevin J., Dentro, Stefan C., Deshwar, Amit G., Donmez, Nilgun, Drews, Ruben M., Gerstung, Moritz, Ha, Gavin, Haase, Kerstin, Jerman, Lara, Ji, Yuan, Jolly, Clemency, Lee, Juhee, Lee-Six, Henry, Malikic, Salem, Mitchell, Thomas J., Morris, Quaid D., Oesper, Layla, Peifer, Martin, Peto, Myron, Rosebrock, Daniel, Rubanova, Yulia, Salcedo, Adriana, Sengupta, Subhajit, Shi, Ruian, Shin, Seung Jun, Spiro, Oliver, Vembu, Shankar, Wintersinger, Jeffrey A., Yang, Tsun-Po, Yu, Kaixian, Zhu, Hongtu, Spellman, Paul T., Weinstein, John N., Chen, Yiwen, Fujita, Masashi, Han, Leng, Hasegawa, Takanori, Komura, Mitsuhiro, Li, Jun, Mizuno, Shinichi, Shimizu, Eigo, Wang, Yumeng, Xu, Yanxun, Yamaguchi, Rui, Yang, Fan, Yang, Yang, Yoon, Christopher J., Yuan, Yuan, Liang, Han, Alawi, Malik, Borozan, Ivan, Brewer, Daniel S., Cooper, Colin S., Desai, Nikita, Grundhoff, Adam, Iskar, Murat, Su, Xiaoping, Zapatka, Marc, Lichter, Peter, Alsop, Kathryn, Bruxner, Timothy J. C., Christ, Angelika N., Cordner, Stephen M., Cowin, Prue A., Drapkin, Ronny, Fereday, Sian, George, Joshy, Hamilton, Anne, Holmes, Oliver, Hung, Jillian A., Kassahn, Karin S., Kazakoff, Stephen H., Kennedy, Catherine J., Leonard, Conrad R., Mileshkin, Linda, Miller, David K., Arnau, Gisela Mir, Mitchell, Chris, Newell, Felicity, Nones, Katia, Patch, Ann-Marie, Quinn, Michael C., Taylor, Darrin F., Thorne, Heather, Traficante, Nadia, Vedururu, Ravikiran, Waddell, Nick M., Waring, Paul M., Wood, Scott, Xu, Qinying, DeFazio, Anna, Anderson, Matthew J., Antonello, Davide, Barbour, Andrew P., Bassi, Claudio, Bersani, Samantha, Cataldo, Ivana, Chantrill, Lorraine A., Chiew, Yoke-Eng, Chou, Angela, Cingarlini, Sara, Cloonan, Nicole, Corbo, Vincenzo, Davi, Maria Vittoria, Duthie, Fraser R., Gill, Anthony J., Graham, Janet S., Harliwong, Ivon, Jamieson, Nigel B., Johns, Amber L., Kench, James G., Landoni, Luca, Lawlor, Rita T., Mafficini, Andrea, Merrett, Neil D., Miotto, Marco, Musgrove, Elizabeth A., Nagrial, Adnan M., Oien, Karin A., Pajic, Marina, Pinese, Mark, Robertson, Alan J., Rooman, Ilse, Rusev, Borislav C., Samra, Jaswinder S., Scardoni, Maria, Scarlett, Christopher J., Scarpa, Aldo, Sereni, Elisabetta, Sikora, Katarzyna O., Simbolo, Michele, Taschuk, Morgan L., Toon, Christopher W., Vicentini, Caterina, Wu, Jianmin, Zeps, Nikolajs, Behren, Andreas, Burke, Hazel, Cebon, Jonathan, Dagg, Rebecca A., De Paoli-Iseppi, Ricardo, Dutton-Regester, Ken, Field, Matthew A., Fitzgerald, Anna, Hersey, Peter, Jakrot, Valerie, Johansson, Peter A., Kakavand, Hojabr, Kefford, Richard F., Lau, Loretta M. S., Long, Georgina, V, Pickett, Hilda A., Pritchard, Antonia L., Pupo, Gulietta M., Saw, Robyn P. M., Schramm, Sarah-Jane, Shang, Catherine A., Shang, Ping, Spillane, Andrew J., Stretch, Jonathan R., Tembe, Varsha, Thompson, John F., Vilain, Ricardo E., Wilmott, James S., Yang, Jean Y., Hayward, Nicholas K., Mann, Graham J., Scolyer, Richard A., Bartlett, John, Bavi, Prashant, Chadwick, Dianne E., Chan-Seng-Yue, Michelle, Cleary, Sean, Connor, Ashton A., Czajka, Karolina, Denroche, Robert E., Dhani, Neesha C., Eagles, Jenna, Gallinger, Steven, Grant, Robert C., Hedley, David, Hollingsworth, Michael A., Jang, Gun Ho, Johns, Jeremy, Kalimuthu, Sangeetha, Liang, Sheng-Ben, Lungu, Ilinca, Luo, Xuemei, Mbabaali, Faridah, McPherson, Treasa A., Miller, Jessica K., Moore, Malcolm J., Notta, Faiyaz, Pasternack, Danielle, Petersen, Gloria M., Roehrl, Michael H. A., Sam, Michelle, Selander, Iris, Serra, Stefano, Shahabi, Sagedeh, Thayer, Sarah P., Timms, Lee E., Wilson, Gavin W., Wilson, Julie M., Wouters, Bradly G., McPherson, John D., Beck, Timothy A., Bhandari, Vinayak, Collins, Colin C., Fleshner, Neil E., Fox, Natalie S., Fraser, Michael, Heisler, Lawrence E., Lalonde, Emilie, Livingstone, Julie, Meng, Alice, Sabelnykova, Veronica Y., Shiah, Yu-Jia, Van Der Kwast, Theodorus, Bristow, Robert G., Ding, Shuai, Fan, Daiming, Li, Lin, Nie, Yongzhan, Xiao, Xiao, Xing, Rui, Yang, Shanlin, Yu, Yingyan, Zhou, Yong, Banks, Rosamonde E., Bourque, Guillaume, Brennan, Paul, Letourneau, Louis, Riazalhosseini, Yasser, Scelo, Ghislaine, Vasudev, Naveen, Viksna, Juris, Lathrop, Mark, Tost, Jorg, Ahn, Sung-Min, Aparicio, Samuel, Arnould, Laurent, Aure, M. R., Bhosle, Shriram G., Birney, Ewan, Borg, Ake, Boyault, Sandrine, Brinkman, Arie B., Brock, Jane E., Broeks, Annegien, Borresen-Dale, Anne-Lise, Caldas, Carlos, Chin, Suet-Feung, Davies, Helen, Desmedt, Christine, Dirix, Luc, Dronov, Serge, Ehinger, Anna, Eyfjord, Jorunn E., Fatima, Aquila, Foekens, John A., Futreal, P. Andrew, Garred, Oystein, Giri, Dilip D., Glodzik, Dominik, Grabau, Dorthe, Hilmarsdottir, Holmfridur, Hooijer, Gerrit K., Jacquemier, Jocelyne, Jang, Se Jin, Jonasson, Jon G., Jonkers, Jos, Kim, Hyung-Yong, King, Tari A., Knappskog, Stian, Kong, Gu, Krishnamurthy, Savitri, Lakhani, Sunil R., Langerod, Anita, Larsimont, Denis, Lee, Hee Jin, Lee, Jeong-Yeon, Lee, Ming Ta Michael, Lingjaerde, Ole Christian, MacGrogan, Gaetan, Martens, John W. M., O'Meara, Sarah, Pauporte, Iris, Pinder, Sarah, Pivot, Xavier, Provenzano, Elena, Purdie, Colin A., Ramakrishna, Manasa, Ramakrishnan, Kamna, Reis-Filho, Jorge, Richardson, Andrea L., Ringner, Markus, Rodriguez, Javier Bartolome, Rodriguez-Gonzalez, F. German, Romieu, Gilles, Salgado, Roberto, Sauer, Torill, Shepherd, Rebecca, Sieuwerts, Anieta M., Simpson, Peter T., Smid, Marcel, Sotiriou, Christos, Span, Paul N., Stefansson, Olafur Andri, Stenhouse, Alasdair, Stunnenberg, Henk G., Sweep, Fred, Tan, Benita Kiat Tee, Thomas, Gilles, Thompson, Alastair M., Tommasi, Stefania, Treilleux, Isabelle, Tutt, Andrew, Ueno, Naoto T., Van Laere, Steven, Van den Eynden, Gert G., Vermeulen, Peter, Viari, Alain, Vincent-Salomon, Anne, Wong, Bernice H., Yates, Lucy, Zou, Xueqing, van Deurzen, Carolien H. M., van de Vijver, Marc J., van't Veer, Laura, Ammerpohl, Ole, Aukema, Sietse, Bergmann, Anke K., Bernhart, Stephan H., Borkhardt, Arndt, Borst, Christoph, Burkhardt, Birgit, Claviez, Alexander, Goebler, Maria Elisabeth, Haake, Andrea, Haas, Siegfried, Hansmann, Martin, Hoell, Jessica, I, Hummel, Michael, Karsch, Dennis, Klapper, Wolfram, Kneba, Michael, Kreuz, Markus, Kube, Dieter, Kueppers, Ralf, Lenze, Dido, Loeffler, Markus, Lopez, Cristina, Mantovani-Loeffler, Luisa, Moeller, Peter, Ott, German, Radlwimmer, Bernhard, Richter, Julia, Rohde, Marius, Rosenstiel, Philip C., Rosenwald, Andreas, Schilhabel, Markus B., Schreiber, Stefan, Stadler, Peter F., Staib, Peter, Stilgenbauer, Stephan, Sungalee, Stephanie, Szczepanowski, Monika, Toprak, Umut H., Truemper, Lorenz H. P., Wagener, Rabea, Zenz, Thorsten, Hovestadt, Volker, von Kalle, Christof, Kool, Marcel, Korshunov, Andrey, Landgraf, Pablo, Lehrach, Hans, Northcott, Paul A., Pfister, Stefan M., Reifenberger, Guido, Warnatz, Hans-Joerg, Wolf, Stephan, Yaspo, Marie-Laure, Assenov, Yassen, Gerhauser, Clarissa, Minner, Sarah, Schlomm, Thorsten, Simon, Ronald, Sauter, Guido, Sueltmann, Holger, Biswas, Nidhan K., Maitra, Arindam, Majumder, Partha P., Sarin, Rajiv, Barbi, Stefano, Bonizzato, Giada, Cantu, Cinzia, Dei Tos, Angelo P., Fassan, Matteo, Grimaldi, Sonia, Luchini, Claudio, Malleo, Giuseppe, Marchegiani, Giovanni, Milella, Michele, Paiella, Salvatore, Pea, Antonio, Pederzoli, Paolo, Ruzzenente, Andrea, Salvia, Roberto, Sperandio, Nicola, Arai, Yasuhito, Hama, Natsuko, Hiraoka, Nobuyoshi, Hosoda, Fumie, Nakamura, Hiromi, Ojima, Hidenori, Okusaka, Takuji, Totoki, Yasushi, Urushidate, Tomoko, Fukayama, Masashi, Ishikawa, Shumpei, Katai, Hitoshi, Katoh, Hiroto, Komura, Daisuke, Rokutan, Hirofumi, Saito-Adachi, Mihoko, Suzuki, Akihiro, Taniguchi, Hirokazu, Tatsuno, Kenji, Ushiku, Tetsuo, Yachida, Shinichi, Yamamoto, Shogo, Aikata, Hiroshi, Arihiro, Koji, Ariizumi, Shun-ichi, Chayama, Kazuaki, Furuta, Mayuko, Gotoh, Kunihito, Hayami, Shinya, Hirano, Satoshi, Kawakami, Yoshiiku, Maejima, Kazuhiro, Nakamura, Toru, Nakano, Kaoru, Ohdan, Hideki, Sasaki-Oku, Aya, Tanaka, Hiroko, Ueno, Masaki, Yamamoto, Masakazu, Yamaue, Hiroki, Choo, Su Pin, Cutcutache, Ioana, Khuntikeo, Narong, Ong, Choon Kiat, Pairojkul, Chawalit, Popescu, Irinel, Ahn, Keun Soo, Aymerich, Marta, Lopez-Guillermo, Armando, Lopez-Otin, Carlos, Puente, Xose S., Campo, Elias, Amary, Fernanda, Baumhoer, Daniel, Behjati, Sam, Bjerkehagen, Bodil, Futreal, P. A., Myklebost, Ola, Pillay, Nischalan, Tarpey, Patrick, Tirabosco, Roberto, Zaikova, Olga, Flanagan, Adrienne M., Boultwood, Jacqueline, Bowen, David T., Cazzola, Mario, Green, Anthony R., Hellstrom-Lindberg, Eva, Malcovati, Luca, Nangalia, Jyoti, Papaemmanuil, Elli, Vyas, Paresh, Ang, Yeng, Barr, Hugh, Beardsmore, Duncan, Eldridge, Matthew, Gossage, James, Grehan, Nicola, Hanna, George B., Hayes, Stephen J., Hupp, Ted R., Khoo, David, Lagergren, Jesper, Lovat, Laurence B., MacRae, Shona, O'Donovan, Maria, O'Neill, J. Robert, Parsons, Simon L., Preston, Shaun R., Puig, Sonia, Roques, Tom, Sanders, Grant, Sothi, Sharmila, Tavare, Simon, Tucker, Olga, Turkington, Richard, Underwood, Timothy J., Welch, Ian, Fitzgerald, Rebecca C., Berney, Daniel M., De Bono, Johann S., Cahill, Declan, Camacho, Niedzica, Dennis, Nening M., Dudderidge, Tim, Edwards, Sandra E., Fisher, Cyril, Foster, Christopher S., Ghori, Mohammed, Gill, Pelvender, Gnanapragasam, Vincent J., Gundem, Gunes, Hamdy, Freddie C., Hawkins, Steve, Hazell, Steven, Howat, William, Isaacs, William B., Karaszi, Katalin, Kay, Jonathan D., Khoo, Vincent, Kote-Jarai, Zsofia, Kremeyer, Barbara, Kumar, Pardeep, Lambert, Adam, Leongamornlert, Daniel A., Livni, Naomi, Lu, Yong-Jie, Luxton, Hayley J., Marsden, Luke, Massie, Charlie E., Matthews, Lucy, Mayer, Erik, McDermott, Ultan, Merson, Sue, Neal, David E., Ng, Anthony, Nicol, David, Ogden, Christopher, Rowe, Edward W., Shah, Nimish C., Thomas, Sarah, Thompson, Alan, Verrill, Clare, Visakorpi, Tapio, Warren, Anne Y., Whitaker, Hayley C., Zhang, Hongwei, van As, Nicholas, Eeles, Rosalind A., Abeshouse, Adam, Agrawal, Nishant, Akbani, Rehan, Al Ahmadie, Hikmat, Albert, Monique, Aldape, Kenneth, Ally, Adrian, Appelbaum, Elizabeth L., Armenia, Joshua, Asa, Sylvia, Auman, J. 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M., Liu, Fei Fei, Lu, Yiling, Lype, Lisa, Ma, Yussanne, Maglinte, Dennis T., Mardis, Elaine R., Marks, Jeffrey, Marra, Marco A., Matthew, Thomas J., Mayo, Michael, McCune, Karen, Meier, Samuel R., Meng, Shaowu, Mieczkowski, Piotr A., Mikkelsen, Tom, Miller, Christopher A., Mills, Gordon B., Moore, Richard A., Morrison, Carl, Mose, Lisle E., Moser, Catherine D., Mungall, Andrew J., Mungall, Karen, Mutch, David, Muzny, Donna M., Myers, Jerome, Newton, Yulia, Noble, Michael S., O'Donnell, Peter, O'Neill, Brian Patrick, Ochoa, Angelica, Park, Joong-Won, Parker, Joel S., Pass, Harvey, Pastore, Alessandro, Pennell, Nathan A., Perou, Charles M., Petrelli, Nicholas, Potapova, Olga, Rader, Janet S., Ramalingam, Suresh, Rathmell, W. Kimryn, Reuter, Victor, Reynolds, Sheila M., Ringel, Matthew, Roach, Jeffrey, Roberts, Lewis R., Robertson, A. Gordon, Sadeghi, Sara, Saller, Charles, Sanchez-Vega, Francisco, Schadendorf, Dirk, Schein, Jacqueline E., Schmidt, Heather K., Schultz, Nikolaus, Seethala, Raja, Senbabaoglu, Yasin, Shelton, Troy, Shi, Yan, Shih, Juliann, Shmulevich, Ilya, Shriver, Craig, Signoretti, Sabina, Simons, Janae, V, Singer, Samuel, Sipahimalani, Payal, Skelly, Tara J., McCune, Karen Smith, Socci, Nicholas D., Soloway, Matthew G., Sood, Anil K., Tam, Angela, Tan, Donghui, Tarnuzzer, Roy, Thiessen, Nina, Thompson, R. Houston, Thorne, Leigh B., Tsao, Ming, Umbricht, Christopher, Van Den Berg, David J., Van Meir, Erwin G., Veluvolu, Umadevi, Voet, Douglas, Wang, Linghua, Weinberger, Paul, Weisenberger, Daniel J., Wigle, Dennis, Wilkerson, Matthew D., Wilson, Richard K., Winterhoff, Boris, Wiznerowicz, Maciej, Wong, Tina, Wong, Winghing, Xi, Liu, Yau, Christina, Zhang, Hailei, Zhang, Hongxin, and Zhang, Jiashan
- Abstract
Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this variation at the whole-genome scale(1-3). Here we report the integrative analysis of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types from the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA). We describe the generation of the PCAWG resource, facilitated by international data sharing using compute clouds. On average, cancer genomes contained 4-5 driver mutations when combining coding and non-coding genomic elements; however, in around 5% of cases no drivers were identified, suggesting that cancer driver discovery is not yet complete. Chromothripsis, in which many clustered structural variants arise in a single catastrophic event, is frequently an early event in tumour evolution; in acral melanoma, for example, these events precede most somatic point mutations and affect several cancer-associated genes simultaneously. Cancers with abnormal telomere maintenance often originate from tissues with low replicative activity and show several mechanisms of preventing telomere attrition to critical levels. Common and rare germline variants affect patterns of somatic mutation, including point mutations, structural variants and somatic retrotransposition. A collection of papers from the PCAWG Consortium describes non-coding mutations that drive cancer beyond those in the TERT promoter(4); identifies new signatures of mutational processes that cause base substitutions, small insertions and deletions and structural variation(5,6); analyses timings and patterns of tumour evolution(7); describes the diverse transcriptional consequences of somatic mutation on splicing, expression levels, fusion genes and promoter activity(8,9); and evaluates a range of more-specialized features of cancer genomes(8,10-18).
- Published
- 2020
47. Human chromosome 11 DNA sequence and analysis including novel gene identification
- Author
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Taylor, Todd D., Noguchi, Hideki, Totoki, Yasushi, Toyoda, Atsushi, Kuroki, Yoko, Dewar, Ken, Lloyd, Christine, Itoh, Takehiko, Takeda, Tadayuki, Kim, Dae-Won, She, Xinwei, Barlow, Karen F., Bloom, Toby, Bruford, Elspeth, Chang, Jean L., Cuomo, Christina A., Eichler, Evan, FitzGerald, Michael G., Jaffe, David B., LaButti, Kurt, Nicol, Robert, Park, Hong-Seog, Seaman, Christopher, Sougnez, Carrie, Yang, Xiaoping, Zimmer, Andrew R., Zody, Michael C., Birren, Bruce W., Nusbaum, Chad, Fujiyama, Asao, Hattori, Masahira, Rogers, Jane, Lander, Eric S., and Sakaki, Yoshiyuki
- Subjects
Environmental issues ,Science and technology ,Zoology and wildlife conservation - Abstract
Author(s): Todd D. Taylor (corresponding author) [1]; Hideki Noguchi [1, 10]; Yasushi Totoki [1]; Atsushi Toyoda [1]; Yoko Kuroki [1]; Ken Dewar [2, 10]; Christine Lloyd [3]; Takehiko Itoh [4]; [...]
- Published
- 2006
- Full Text
- View/download PDF
48. Impaired tumor immune response in metastatic tumors is a selective pressure for neutral evolution in CRC cases
- Author
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Sakimura, Shotaro, primary, Nagayama, Satoshi, additional, Fukunaga, Mitsuko, additional, Hu, Qingjiang, additional, Kitagawa, Akihiro, additional, Kobayashi, Yuta, additional, Hasegawa, Takanori, additional, Noda, Miwa, additional, Kouyama, Yuta, additional, Shimizu, Dai, additional, Saito, Tomoko, additional, Niida, Atsushi, additional, Tsuruda, Yusuke, additional, Otsu, Hajime, additional, Matsumoto, Yoshihiro, additional, Uchida, Hiroki, additional, Masuda, Takaaki, additional, Sugimachi, Keishi, additional, Sasaki, Shin, additional, Yamada, Kazutaka, additional, Takahashi, Kazuki, additional, Innan, Hideki, additional, Suzuki, Yutaka, additional, Nakamura, Hiromi, additional, Totoki, Yasushi, additional, Mizuno, Shinichi, additional, Ohshima, Masanobu, additional, Shibata, Tatsuhiro, additional, and Mimori, Koshi, additional
- Published
- 2021
- Full Text
- View/download PDF
49. DNA sequence and analysis of human chromosome 18
- Author
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Nusbaum, Chad, Zody, Michael C., Borowsky, Mark L., Kamal, Michael, Kodira, Chinnappa D., Taylor, Todd D., Whittaker, Charles A., Chang, Jean L., Cuomo, Christina A., Dewar, Ken, FitzGerald, Michael G., Yang, Xiaoping, Abouelleil, Amr, Allen, Nicole R., Anderson, Scott, Bloom, Toby, Bugalter, Boris, Butler, Jonathan, Cook, April, DeCaprio, David, Engels, Reinhard, Garber, Manuel, Gnirke, Andreas, Hafez, Nabil, Hall, Jennifer L., Norman, Catherine Hosage, Itoh, Takehiko, Jaffe, David B., Kuroki, Yoko, Lehoczky, Jessica, Lui, Annie, Macdonald, Pendexter, Mauceli, Evan, Mikkelsen, Tarjei S., Naylor, Jerome W., Nicol, Robert, Nguyen, Cindy, Noguchi, Hideki, O'Leary, Sinead B., Piqani, Bruno, L Smith, Cherylyn, Talamas, Jessica A., Topham, Kerri, Totoki, Yasushi, Toyoda, Atsushi, Wain, Hester M., Young, Sarah K., Zeng, Qiandong, Zimmer, Andrew R., Fujiyama, Asao, Hattori, Masahira, Birren, Bruce W., Sakaki, Yoshiyuki, and Lander, Eric S.
- Subjects
Environmental issues ,Science and technology ,Zoology and wildlife conservation - Abstract
Author(s): Chad Nusbaum (corresponding author) [1]; Michael C. Zody [1]; Mark L. Borowsky [1]; Michael Kamal [1]; Chinnappa D. Kodira [1]; Todd D. Taylor [2]; Charles A. Whittaker [1, 8]; [...]
- Published
- 2005
- Full Text
- View/download PDF
50. GCT-52. TRANSCRIPTOME OF CENTRAL NERVOUS SYSTEM GERM CELL TUMOR REVEALS ITS PATHOGENESIS AND CONTRASTS WITH TESTICULAR COUNTERPARTS IN INTEGRATED OMICS ANALYSIS
- Author
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Takami, Hirokazu, primary, Elzawahry, Asmaa, additional, Kato, Mamoru, additional, Fukuoka, Kohei, additional, Mamatjan, Yasin, additional, Suzuki, Tomonari, additional, Yanagisawa, Takaaki, additional, Matsushita, Yuko, additional, Nakamura, Taishi, additional, Yamasaki, Kai, additional, Mukasa, Akitake, additional, Saito, Nobuhito, additional, Kanamori, Masayuki, additional, Kumabe, Toshihiro, additional, Tominaga, Teiji, additional, Kobayashi, Keiichi, additional, Nagane, Motoo, additional, Iuchi, Toshihiko, additional, Tamura, Kaoru, additional, Maehara, Taketoshi, additional, Sugiyama, Kazuhiko, additional, Nakada, Mitsutoshi, additional, Kanemura, Yonehiro, additional, Nonaka, Masahiro, additional, Asai, Akio, additional, Yokogami, Kiyotaka, additional, Takeshima, Hideo, additional, Narita, Yoshitaka, additional, Shibui, Soichiro, additional, Nakazato, Yoichi, additional, Totoki, Yasushi, additional, Shibata, Tatsuhiro, additional, Nishikawa, Ryo, additional, Matsutani, Masao, additional, and Ichimura, Koichi, additional
- Published
- 2020
- Full Text
- View/download PDF
Catalog
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