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5. Empagliflozin in the treatment of heart failure with reduced ejection fraction in addition to background therapies and therapeutic combinations (EMPEROR-Reduced): a post-hoc analysis of a randomised, double-blind trial

Author

Packer, M, Anker, S, Butler, J, Filippatos, G, Pocock, S, Zannad, F, Ferreira, JP, Brueckmann, M, George, J, Jamal, W, Welty, FK, Palmer, M, Clayton, T, Parhofer, KG, Pedersen, TR, Greenberg, B, Konstam, MA, Lees, KR, Carson, P, Doehner, W, Miller, A, Haas, M, Pehrson, S, Komajda, M, Anand, I, Teerlink, J, Rabinstein, A, Steiner, T, Kamel, H, Tsivgoulis, G, Lewis, J, Freston, J, Kaplowitz, N, Mann, J, Petrie, J, Perrone, S, Nicholls, S, Janssens, S, Bocchi, E, Giannetti, N, Verma, S, Zhang, J, Spinar, J, Seronde, M-F, Boehm, M, Merkely, B, Chopra, V, Senni, M, Taddi, S, Tsutsui, H, Choi, D-J, Chuquiure, E, La Rocca, HPB, Ponikowski, P, Juanatey, JRG, Squire, I, Januzzi, J, Pina, I, Bernstein, R, Cheung, A, Green, J, Kaul, S, Lam, C, Lip, G, Marx, N, McCullough, P, Mehta, C, Rosenstock, J, Sattar, N, Scirica, B, Shah, S, Wanner, C, Aizenberg, D, Cartasegna, L, Colombo Berra, F, Colombo, H, Fernandez Moutin, M, Glenny, J, Alvarez Lorio, C, Anauch, D, Campos, R, Facta, A, Fernandez, A, Ahuad Guerrero, R, Lobo Márquez, L, Leon de la Fuente, RA, Mansilla, M, Hominal, M, Hasbani, E, Najenson, M, Moises Azize, G, Luquez, H, Guzman, L, Sessa, H, Amuchástegui, M, Salomone, O, Perna, E, Piskorz, D, Sicer, M, Perez de Arenaza, D, Zaidman, C, Nani, S, Poy, C, Resk, J, Villarreal, R, Majul, C, Smith Casabella, T, Sassone, S, Liberman, A, Carnero, G, Caccavo, A, Berli, M, Budassi, N, Bono, J, Alvarisqueta, A, Amerena, J, Kostner, K, Hamilton, A, Begg, A, Beltrame, J, Colquhoun, D, Gordon, G, Sverdlov, A, Vaddadi, G, Wong, J, Coller, J, Prior, D, Friart, A, Leone, A, Vervoort, G, Timmermans, P, Troisfontaines, P, Franssen, C, Sarens, T, Vandekerckhove, H, Van De Borne, P, Chenot, F, De Sutter, J, De Vuyst, E, Debonnaire, P, Dupont, M, Pereira Dutra, O, Canani, LH, Vieira Moreira, MdC, de Souza, W, Backes, LM, Maia, L, De Souza Paolino, B, Manenti, ER, Saporito, W, Villaça Guimarães Filho, F, Franco Hirakawa, T, Saliba, LA, Neuenschwander, FC, de Freitas Zerbini, CA, Gonçalves, G, Gonçalves Mello, Y, Ascenção de Souza, J, Beck da Silva Neto, L, Bocchi, EA, Da Silveira, J, de Moura Xavier Moraes Junior, JB, de Souza Neto, JD, Hernandes, M, Finimundi, HC, Sampaio, CR, Vasconcellos, E, Neves Mancuso, FJ, Noya Rabelo, MM, Rodrigues Bacci, M, Santos, F, Vidotti, M, Simões, MV, Gomes, FL, Vieira Nascimento, C, Precoma, D, Helfenstein Fonseca, FA, Ribas Fortes, JA, Leães, PE, Campos de Albuquerque, D, Kerr Saraiva, JF, Rassi, S, Alves da Costa, FA, Reis, G, Zieroth, S, Dion, D, Savard, D, Bourgeois, R, Constance, C, Anderson, K, Leblanc, M-H, Yung, D, Swiggum, E, Pliamm, L, Pesant, Y, Tyrrell, B, Huynh, T, Spiegelman, J, Lavoie, J-P, Hartleib, M, Bhargava, R, Straatman, L, Virani, S, Costa-Vitali, A, Hill, L, Heffernan, M, Khaykin, Y, Ricci, J, Senaratne, M, Zhai, A, Lubelsky, B, Toma, M, Yao, L, McKelvie, R, Noronha, L, Babapulle, M, Pandey, A, Curnew, G, Lavoie, A, Berlingieri, J, Kouz, S, Lonn, E, Chehayeb, R, Zheng, Y, Sun, Y, Cui, H, Fan, Z, Han, X, Jiang, X, Tang, Q, Zhou, J, Zheng, Z, Zhang, X, Zhang, N, Zhang, Y, Shen, A, Yu, J, Ye, J, Yao, Y, Yan, J, Xu, X, Wang, Z, Ma, J, Li, Y, Li, S, Lu, S, Kong, X, Song, Y, Yang, G, Yao, Z, Pan, Y, Guo, X, Sun, Z, Dong, Y, Zhu, J, Peng, D, Yuan, Z, Lin, J, Yin, Y, Jerabek, O, Burianova, H, Fiala, T, Hubac, J, Ludka, O, Monhart, Z, Vodnansky, P, Zeman, K, Foldyna, D, Krupicka, J, Podpera, I, Busak, L, Radvan, M, Vomacka, Z, Prosecky, R, Cifkova, R, Durdil, V, Vesely, J, Vaclavik, J, Cervinka, P, Linhart, A, Brabec, T, Miklik, R, Bourhaial, H, Olbrich, H-G, Genth-Zotz, S, Kemala, E, Lemke, B, Böhm, M, Schellong, S, Rieker, W, Heitzer, T, Ince, H, Faghih, M, Birkenfeld, A, Begemann, A, Ghanem, A, Ujeyl, A, von Haehling, S, Dorsel, T, Bauersachs, J, Prull, M, Weidemann, F, Darius, H, Nickenig, G, Wilke, A, Sauter, J, Rauch-Kroehnert, U, Frey, N, Schulze, CP, König, W, Maier, L, Menzel, F, Proskynitopoulos, N, Ebert, H-H, Sarnighausen, H-E, Düngen, H-D, Licka, M, Stellbrink, C, Winkelmann, B, Menck, N, López-Sendón, JL, de la Fuente Galán, L, Delgado Jiménez, JF, Manito Lorite, N, Pérez de Juan Romero, M, Galve Basilio, E, Cereto Castro, F, González Juanatey, JR, Gómez, JJ, Sanmartín Fernández, M, Garcia-Moll Marimon, X, Pascual Figal, D, Bover Freire, R, Bonnefoy Cudraz, E, Jobbe Duval, A, Tomasevic, D, Habib, G, Isnard, R, Picard, F, Khanoyan, P, Dubois-Rande, J-L, Galinier, M, Roubille, F, Alexandre, J, Babuty, D, Delarche, N, Berneau, J-B, Girerd, N, Saxena, M, Rosano, G, Yousef, Z, Clifford, C, Arden, C, Bakhai, A, Boos, C, Jenkins, G, Travill, C, Price, D, Koenyves, L, Lakatos, F, Matoltsy, A, Noori, E, Zilahi, Z, Andrassy, P, Kancz, S, Simon, G, Sydo, T, Vorobcsuk, A, Kiss, RG, Toth, K, Szakal, I, Nagy, L, Barany, T, Nagy, A, Szolnoki, E, Chopra, VK, Mandal, S, Rastogi, V, Shah, B, Mullasari, A, Shankar, J, Mehta, V, Oomman, A, Kaul, U, Komarlu, S, Kahali, D, Bhagwat, A, Vijan, V, Ghaisas, NK, Mehta, A, Kashyap, J, Kothari, Y, TaddeI, S, Scherillo, M, Zacà, V, Genovese, S, Salvioni, A, Fucili, A, Fedele, F, Cosmi, F, Volpe, M, Mazzone, C, Esposito, G, Doi, M, Yamamoto, H, Sakagami, S, Oishi, S, Yasaka, Y, Tsuboi, H, Fujino, Y, Matsuoka, S, Watanabe, Y, Himi, T, Ide, T, Ichikawa, M, Kijima, Y, Koga, T, Yuda, S, Fukui, K, Kubota, T, Manita, M, Fujinaga, H, Matsumura, T, Fukumoto, Y, Kato, R, Kawai, Y, Hiasa, G, Kazatani, Y, Mori, M, Ogimoto, A, Inoko, M, Oguri, M, Kinoshita, M, Okuhara, K, Watanabe, N, Ono, Y, Otomo, K, Sato, Y, Matsunaga, T, Takaishi, A, Miyagi, N, Uehara, H, Takaishi, H, Urata, H, Kataoka, T, Matsubara, H, Matsumoto, T, Suzuki, T, Takahashi, N, Imamaki, M, Yoshitama, T, Saito, T, Sekino, H, Furutani, Y, Koda, M, Shinozaki, T, Hirabayashi, K, Tsunoda, R, Yonezawa, K, Hori, H, Yagi, M, Arikawa, M, Hashizume, T, Ishiki, R, Koizumi, T, Nakayama, K, Taguchi, S, Nanasato, M, Yoshida, Y, Tsujiyama, S, Nakamura, T, Oku, K, Shimizu, M, Suwa, M, Momiyama, Y, Sugiyama, H, Kobayashi, K, Inoue, S, Kadokami, T, Maeno, K, Kawamitsu, K, Maruyama, Y, Nakata, A, Shibata, T, Wada, A, Cho, H-J, Na, JO, Yoo, B-S, Choi, J-O, Hong, SK, Shin, J-H, Cho, M-C, Han, SH, Jeong, J-O, Kim, J-J, Kang, SM, Kim, D-S, Kim, MH, Llamas Esperon, G, Illescas Díaz, J, Fajardo Campos, P, Almeida Alvarado, J, Bazzoni Ruiz, A, Echeverri Rico, J, Lopez Alcocer, I, Valle Molina, L, Hernandez Herrera, C, Calvo Vargas, C, Padilla Padilla, FG, Rodriguez Briones, I, Chuquiure Valenzuela, EJJR, Aguilera Real, ME, Carrillo Calvillo, J, Alpizar Salazar, M, Cervantes Escárcega, JL, Velasco Sanchez, R, Al - Windy, N, van Heerebeek, L, Bellersen, L, Brunner-La Rocca, H-P, Post, J, Linssen, GCM, van de Wetering, M, Peters, R, van Stralen, R, Groutars, R, Smits, P, Yilmaz, A, Kok, WEM, Van der Meer, P, Dijkmans, P, Troquay, R, van Alem, AP, Van de Wal, R, Handoko, L, Westendorp, ICD, van Bergen, PFMM, Rensing, BJWM, Hoogslag, P, Kietselaer, B, Kragten, JA, den Hartog, FR, Alings, A, Danilowicz-Szymanowicz, L, Raczak, G, Piesiewicz, W, Zmuda, W, Kus, W, Podolec, P, Musial, W, Drelich, G, Kania, G, Miekus, P, Mazur, S, Janik, A, Spyra, J, Peruga, J, Balsam, P, Krakowiak, B, Szachniewicz, J, Ginel, M, Grzybowski, J, Chrustowski, W, Wojewoda, P, Kalinka, A, Zurakowski, A, Koc, R, Debinski, M, Fil, W, Kujawiak, M, Forys, J, Kasprzak, M, Krol, M, Michalski, P, Mirek-Bryniarska, E, Radwan, K, Skonieczny, G, Stania, K, Skoczylas, G, Madej, A, Jurowiecki, J, Firek, B, Wozakowska-Kaplon, B, Cymerman, K, Neutel, J, Adams, K, Balfour, P, Deswal, A, Djamson, A, Duncan, P, Hong, M, Murray, C, Rinde-Hoffman, D, Woodhouse, S, MacNevin, R, Rama, B, Broome-Webster, C, Kindsvater, S, Abramov, D, Barettella, M, Pinney, S, Herre, J, Cohen, A, Vora, K, Challappa, K, West, S, Baum, S, Cox, J, Jani, S, Karim, A, Akhtar, A, Quintana, O, Paukman, L, Goldberg, R, Bhatti, Z, Budoff, M, Bush, E, Potler, A, Delgado, R, Ellis, B, Dy, J, Fialkow, J, Sangrigoli, R, Ferdinand, K, East, C, Falkowski, S, Donahoe, S, Ebrahimi, R, Kline, G, Harris, B, Khouzam, R, Jaffrani, N, Jarmukli, N, Kazemi, N, Koren, M, Friedman, K, Herzog, W, Silva Enciso, J, Cheung, D, Grover-McKay, M, Hauptman, P, Mikhalkova, D, Hegde, V, Hodsden, J, Khouri, S, McGrew, F, Littlefield, R, Bradley, P, McLaurin, B, Lupovitch, S, Labin, I, Rao, V, Leithe, M, Lesko, M, Lewis, N, Lombardo, D, Mahal, S, Malhotra, V, Dauber, I, Banerjee, A, Needell, J, Miller, G, Paladino, L, Munuswamy, K, Nanna, M, McMillan, E, Mumma, M, Napoli, M, Nelson, W, O'Brien, T, Adlakha, A, Onwuanyi, A, Serota, H, Schmedtje, J, Paraschos, A, Potu, R, Sai-Sudhakar, C, Saltzberg, M, Sauer, A, Shah, P, Skopicki, H, Bui, H, Carr, K, Stevens, G, Tahirkheli, N, Tallaj, J, Yousuf, K, Trichon, B, Welker, J, Tolerico, P, Vest, A, Vivo, R, Wang, X, Abadier, R, Dunlap, S, Weintraub, N, Malik, A, Kotha, P, Zaha, V, Kim, G, Uriel, N, Greene, T, Salacata, A, Arora, R, Gazmuri, R, Kobayashi, J, Iteld, B, Vijayakrishnan, R, Dab, R, Mirza, Z, Marques, V, Nallasivan, M, Bensimhon, D, Peart, B, Saint-Jacques, H, Barringhaus, K, Contreras, J, Gupta, A, Koneru, S, Nguyen, V, Verma, Subodh, Dhingra, Nitish K, Butler, Javed, Anker, Stefan D, Ferreira, Joao Pedro, Filippatos, Gerasimos, Januzzi, James L, Lam, Carolyn S P, Sattar, Naveed, Peil, Barbara, Nordaby, Matias, Brueckmann, Martina, Pocock, Stuart J, Zannad, Faiez, and Packer, Milton

Published
2022
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6. Accumulated soil seed bank of the invasive sand dropseed ( Sporobolus cryptandrus ) poses a challenge for its suppression.

Author

Török, Peter, primary, AMI, Francis David ESPINOZA, additional, Toth, K., additional, CANDO, Patrícia DÍAZ, additional, SUNTAXI, Luis Roberto GUALLICHICO, additional, Andrea, MCINTOSH-BUDAY, additional, HÁBENCZYUS, Alida Anna, additional, Viktória, TÖRŐ-SZIJGYÁRTÓ, additional, Gergely, KOVACSICS-VÁRI, additional, Tölgyesi, Csaba, additional, Tóthmérész, Béla, additional, and Sonkoly, Judit, additional

Published
2023
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7. Reperfusion therapies and in-hospital outcomes for ST-elevation myocardial infarction in europe. the ACVC-EAPCI EORP STEMI registry of the european society of cardiology

Author

Zeymer, U., Ludman, P., Danchin, N., Kala, P., Laroche, C., Sadeghi, M., Caporale, R., Shaheen, S. M., Legutko, J., Iakobsishvili, Z., Alhabib, K. F., Motovska, Z., Studencan, M., Mimoso, J., Becker, D., Alexopoulos, D., Kereseselidze, Z., Stojkovic, S., Zelveian, P., Goda, A., Mirrakhimov, E., Bajraktari, G., Al-Farhan, H., Serpytis, P., Raungaard, B., Marandi, T., Moore, A. M., Quinn, M., Karjalainen, P. P., Tatu-Chitolu, G., Gale, C. P., Maggioni, A. P., Weidinger, F., Sinnaeve, P., Ferrari, R., Karamfilov, K., Lidon, R. -M., Kereselidze, Z., Iakobishvili, Z., Erglis, A., Kedev, S., Dudek, D., Tatu-Chitoiu, G., Shlyakhto, E., Bunc, M., Mourali, M. S., Konte, M., Larras, F., Lefrancq, E. F., Mekhaldi, S., Shuka, N., Pavli, E., Tafaj, E., Gishto, T., Dibra, A., Duka, A., Gjana, A., Kristo, A., Knuti, G., Demiraj, A., Dado, E., Hasimi, E., Simoni, L., Siqeca, M., Sisakian, H., Hayrapetyan, H., Markosyan, S., Galustyan, L., Arustamyan, N., Kzhdryan, H., Pepoyan, S., Zirkik, A., Von Lewinski, D., Paetzold, S., Kienzl, I., Matyas, K., Neunteufl, T., Nikfardjam, M., Neuhold, U., Mihalcz, A., Glaser, F., Steinwender, C., Reiter, C., Grund, M., Hrncic, D., Hoppe, U., Hammerer, M., Hinterbuchner, L., Hengstenberg, C., Delle Karth, G., Lang, I., Winkler, W., Hasun, M., Kastner, J., Havel, C., Derntl, M., Oberegger, G., Hajos, J., Adlbrecht, C., Publig, T., Leitgeb, M. -C., Wilfing, R., Jirak, P., C. -Y., Ho, Puskas, L., Schrutka, L., Spinar, J., Parenica, J., Hlinomaz, O., Fendrychova, V., Semenka, J., Sikora, J., Sitar, J., Groch, L., Rezek, M., Novak, M., Kramarikova, P., Stasek, J., Dusek, J., Zdrahal, P., Polasek, R., Karasek, J., Seiner, J., Sukova, N., Varvarovsky, I., Lazarak, T., Novotny, V., Matejka, J., Rokyta, R., Volovar, S., Belohlavek, J., Siranec, M., Kamenik, M., Kralik, R., Ravkilde, J., Jensen, S. E., Villadsen, A., Villefrance, K., Schmidt Skov, C., Maeng, M., Moeller, K., Hasan-Ali, H., Ahmed, T. A., Hassan, M., Elguindy, A., Farouk Ismail, M., Ibrahim Abd El-Aal, A., El-Sayed Gaafar, A., Magdy Hassan, H., Ahmed Shafie, M., Nabil El-Khouly, M., Bendary, A., Darwish, M., Ahmed, Y., Amin, O. A., Abdelhakim, A., Abosaif, K., Kandil, H., Galal, M. A. G., El Hefny, E. E., El Sayed, M., Aly, K., Mokarrab, M., Osman, M., Abdelhamid, M., Mantawy, S., Ali, M. R., Kaky, S. D., Khalil, V. A., Saraya, M. E. A., Talaat, A., Nabil, M., Mounir, W. M., Mahmoud, K., Aransa, A., Kazamel, G., Anwar, S., Al-Habbaa, A., Abd El Monem, M., Ismael, A., Amin Abu-Sheaishaa, M., Abd Rabou, M. M., Hammouda, T. M. A., Moaaz, M., Elkhashab, K., Ragab, T., Rashwan, A., Rmdan, A., Abdelrazek, G., Ebeid, H., Soliman Ghareeb, H., Farag, N., Zaki, M., Seleem, M., Torki, A., Youssef, M., Allah Nasser, N. A., Rafaat, A., Selim, H., Makram, M. M., Khayyal, M., Malasi, K., Madkour, A., Kolib, M., Alkady, H., Nagah, H., Yossef, M., Wafa, A., Mahfouz, E., Faheem, G., Magdy Moris, M., Ragab, A., Ghazal, M., Mabrouk, A., El-Masry, M., Naseem, M., Samir, S., Reinmets, J., Allvee, M., Saar, A., Ainla, T., Vaide, A., Kisseljova, M., Pakosta, U., Eha, J., Lotamois, K., Sia, J., Myllymaki, J., Pinola, T., Paana, T., Mikkelsson, J., Ampio, M., Tsivilasvili, J., Zurab, P., Agladze, R., Melia, A., Gogoberidze, D., Khubua, N., Totladze, L., Metreveli, I., Chikovani, A., Eitel, I., Poss, J., Werner, M., Constantz, A., Ahrens, C., Tolksdorf, H., Klinger, S., Sack, S., Heer, T., Lekakis, J., Kanakakis, I., Xenogiannis, I., Ermidou, K., Makris, N., Ntalianis, A., Katsaros, F., Revi, E., Kafkala, K., Mihelakis, E., Diakakis, G., Grammatikopoulos, K., Voutsinos, D., Xanthopoulou, I., Mplani, V., Foussas, S., Papakonstantinou, N., Patsourakos, N., Dimopoulos, A., Derventzis, A., Athanasiou, K., Vassilikos, V. P., Papadopoulos, C., Tzikas, S., Vogiatzis, I., Datsios, A., Galitsianos, I., Koutsampasopoulos, K., Grigoriadis, S., Douras, A., Baka, N., Spathis, S., Kyrlidis, T., Hatzinikolaou, H., Kiss, R. G., Nowotta, F., Toth, K., Szabo, S., Lakatos, C., Jambrik, Z., Ruzsa, J., Ruzsa, Z., Rona, S., Toth, J., Vargane Kosik, A., Toth, K. S. B., Nagy, G. G., Ondrejko, Z., Koromi, Z., Botos, B., Pourmoghadas, M., Salehi, A., Massoumi, G., Soleimani, A., Sarrafzadegan, N., Roohafza, H., Azarm, M., Mirmohammadsadeghi, A., Rajabi, D., Rahmani, Y., Siabani, S., Najafi, F., Hamzeh, B., Karim, H., Siabani, H., Saleh, N., Charehjoo, H., Zamzam, L., Al-Temimi, G., Al-Yassin, A., Mohammad, A., Ridha, A., Al-Saedi, G., Atabi, N., Sabbar, O., Mahmood, S., Dakhil, Z., Yaseen, I. F., Almyahi, M., Alkenzawi, H., Alkinani, T., Alyacopy, A., Kearney, P., Twomey, K., Shlomo, N., Beigel, R., Caldarola, P., Rutigliano, D., Sublimi Saponetti, L., Locuratolo, N., Palumbo, V., Scherillo, M., Formigli, D., Canova, P., Musumeci, G., Roncali, F., Metra, M., Lombardi, C., Visco, E., Rossi, L., Meloni, L., Montisci, R., Pippia, V., Marchetti, M. F., Congia, M., Cacace, C., Luca, G., Boscarelli, G., Indolfi, C., Ambrosio, G., Mongiardo, A., Spaccarotella, C., De Rosa, S., Canino, G., Critelli, C., Chiappetta, D., Battista, F., Gabrielli, D., Marziali, A., Bernabo, P., Navazio, A., Guerri, E., Manca, F., Gobbi, M., Oreto, Giuseppe, Andò, Giuseppe, Carerj, Scipione, Saporito, Francesco, Cimmino, Michele, Rigo, F., Zuin, G., Tuccillo, B., Scotto DI Uccio, F., Irace, L., Lorenzoni, G., Meloni, I., Merella, P., Polizzi, G. M., Pino, R., Marzilli, M., Morrone, D., Caravelli, P., Orsini, E., Mosa, S., Piovaccari, G., Santarelli, A., Cavazza, C., Romeo, F., Fedele, F., Mancone, M., Straito, M., Salvi, N., Scarparo, P., Severino, P., Razzini, C., Massaro, G., Cinque, A., Gaudio, C., Barilla, F., Torromeo, C., Porco, L., Mei, M., Iorio, R., Nassiacos, D., Barco, B., Sinagra, G., Falco, L., Priolo, L., Perkan, A., Strana, M., Percuku, L., Berisha, G., Mziu, B., Beishenkulov, M., Abdurashidova, T., Toktosunova, A., Kaliev, K., Serpytis, R., Butkute, E., Lizaitis, M., Broslavskyte, M., Xuereb, R. G., Mercieca Balbi, M., Paris, E., Buttigieg, L., Musial, W., Dobrzycki, S., Dubicki, A., Kazimierczyk, E., Tycinska, A., Wojakowski, W., Kalanska-Lukasik, B., Ochala, A., Wanha, W., Dworowy, S., Sielski, J., Janion, M., Janion-Sadowska, A., Wojtasik-Bakalarz, J., Bryniarski, L., Peruga, J. Z., Jonczyk, M., Jankowski, L., Klecha, A., Michalowska, J., Brzezinski, M., Kozmik, T., Kowalczyk, T., Adamczuk, J., Maliszewski, M., Kuziemka, P., Plaza, P., Jaros, A., Pawelec, A., Sledz, J., Bartus, S., Zmuda, W., Bogusz, M., Wisnicki, M., Szastak, G., Adamczyk, M., Suska, M., Czunko, P., Opolski, G., Kochman, J., Tomaniak, M., Miernik, S., Paczwa, K., Witkowski, A., Opolski, M. P., Staruch, A. D., Kalarus, Z., Honisz, G., Mencel, G., Swierad, M., Podolecki, T., Marques, J., Azevedo, P., Pereira, M. A., Gaspar, A., Monteiro, S., Goncalves, F., Leite, L., Manuel Lopes Dos Santos, W., Amado, J., Pereira, D., Silva, B., Caires, G., Neto, M., Rodrigues, R., Correia, A., Freitas, D., Lourenco, A., Ferreira, F., Sousa, F., Portugues, J., Calvo, L., Almeida, F., Alves, M., Silva, A., Caria, R., Seixo, F., Militaru, C., Ionica, E., Istratoaie, O., Florescu, M., Lipnitckaia, E., Osipova, O., Konstantinov, S., Bukatov, V., Vinokur, T., Egorova, E., Nefedova, E., Levashov, S., Gorbunova, A., Redkina, M., Karaulovskaya, N., Bijieva, F., Babich, N., Smirnova, O., Filyanin, R., Eseva, S., Kutluev, A., Chlopenova, A., Shtanko, A., Kuppar, E., Shaekhmurzina, E., Ibragimova, M., Mullahmetova, M., Chepisova, M., Kuzminykh, M., Betkaraeva, M., Namitokov, A., Khasanov, N., Baleeva, L., Galeeva, Z., Magamedkerimova, F., Ivantsov, E., Tavlueva, E., Kochergina, A., Sedykh, D., Kosmachova, E., Skibitskiy, V., Porodenko, N., Litovka, K., Ulbasheva, E., Niculina, S., Petrova, M., Harkov, E., Tsybulskaya, N., Lobanova, A., Chernova, A., Kuskaeva, A., Kuskaev, A., Ruda, M., Zateyshchikov, D., Gilarov, M., Konstantinova, E., Koroleva, O., Averkova, A., Zhukova, N., Kalimullin, D., Borovkova, N., Tokareva, A., Buyanova, M., Khaisheva, L., Pirozhenko, A., Novikova, T., Yakovlev, A., Tyurina, T., Lapshin, K., Moroshkina, N., Kiseleva, M., Fedorova, S., Krylova, L., Duplyakov, D., Semenova, Y., Rusina, A., Ryabov, V., Syrkina, A., Demianov, S., Reitblat, O., Artemchuk, A., Efremova, E., Makeeva, E., Menzorov, M., Shutov, A., Klimova, N., Shevchenko, I., Elistratova, O., Kostyuckova, O., Islamov, R., Budyak, V., Ponomareva, E., Ullah Jan, U., Alshehri, A. 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N., Abdin Hussein, G., Butt, M., Markovic Nikolic, N., Obradovic, S., Djenic, N., Brajovic, M., Davidovic, A., Romanovic, R., Novakovic, V., Dekleva, M., Spasic, M., Dzudovic, B., Jovic, Z., Cvijanovic, D., Veljkovic, S., Ivanov, I., Cankovic, M., Jarakovic, M., Kovacevic, M., Trajkovic, M., Mitov, V., Jovic, A., Hudec, M., Gombasky, M., Sumbal, J., Bohm, A., Baranova, E., Kovar, F., Samos, M., Podoba, J., Kurray, P., Obona, T., Remenarikova, A., Kollarik, B., Verebova, D., Kardosova, G., Alusik, D., Macakova, J., Kozlej, M., Bayes-Genis, A., Sionis, A., Garcia Garcia, C., Duran Cambra, A., Labata Salvador, C., Rueda Sobella, F., Sans Rosello, J., Vila Perales, M., Oliveras Vila, T., Ferrer Massot, M., Baneras, J., Lekuona, I., Zugazabeitia, G., Fernandez-Ortiz, A., Viana Tejedor, A., Ferrera, C., Alvarez, V., DIaz-Castro, O., Agra-Bermejo, R. 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M., Khayyal, M., Malasi, K., Madkour, A., Kolib, M., Alkady, H., Nagah, H., Yossef, M., Wafa, A., Mahfouz, E., Faheem, G., Magdy Moris, M., Ragab, A., Ghazal, M., Mabrouk, A., El-Masry, M., Naseem, M., Samir, S., Reinmets, J., Allvee, M., Saar, A., Ainla, T., Vaide, A., Kisseljova, M., Pakosta, U., Eha, J., Lotamois, K., Sia, J., Myllymaki, J., Pinola, T., Paana, T., Mikkelsson, J., Ampio, M., Tsivilasvili, J., Zurab, P., Agladze, R., Melia, A., Gogoberidze, D., Khubua, N., Totladze, L., Metreveli, I., Chikovani, A., Eitel, I., Poss, J., Werner, M., Constantz, A., Ahrens, C., Tolksdorf, H., Klinger, S., Sack, S., Heer, T., Lekakis, J., Kanakakis, I., Xenogiannis, I., Ermidou, K., Makris, N., Ntalianis, A., Katsaros, F., Revi, E., Kafkala, K., Mihelakis, E., Diakakis, G., Grammatikopoulos, K., Voutsinos, D., Xanthopoulou, I., Mplani, V., Foussas, S., Papakonstantinou, N., Patsourakos, N., Dimopoulos, A., Derventzis, A., Athanasiou, K., Vassilikos, V. 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F., Almyahi, M., Alkenzawi, H., Alkinani, T., Alyacopy, A., Kearney, P., Twomey, K., Shlomo, N., Beigel, R., Caldarola, P., Rutigliano, D., Sublimi Saponetti, L., Locuratolo, N., Palumbo, V., Scherillo, M., Formigli, D., Canova, P., Musumeci, G., Roncali, F., Metra, M., Lombardi, C., Visco, E., Rossi, L., Meloni, L., Montisci, R., Pippia, V., Marchetti, M. F., Congia, M., Cacace, C., Luca, G., Boscarelli, G., Indolfi, C., Ambrosio, G., Mongiardo, A., Spaccarotella, C., De Rosa, S., Canino, G., Critelli, C., Chiappetta, D., Battista, F., Gabrielli, D., Marziali, A., Bernabo, P., Navazio, A., Guerri, E., Manca, F., Gobbi, M., Oreto, G., Ando, G., Carerj, S., Saporito, F., Cimmino, M., Rigo, F., Zuin, G., Tuccillo, B., Scotto DI Uccio, F., Irace, L., Lorenzoni, G., Meloni, I., Merella, P., Polizzi, G. M., Pino, R., Marzilli, M., Morrone, D., Caravelli, P., Orsini, E., Mosa, S., Piovaccari, G., Santarelli, A., Cavazza, C., Romeo, F., Fedele, F., Mancone, M., Straito, M., Salvi, N., Scarparo, P., Severino, P., Razzini, C., Massaro, G., Cinque, A., Gaudio, C., Barilla, F., Torromeo, C., Porco, L., Mei, M., Iorio, R., Nassiacos, D., Barco, B., Sinagra, G., Falco, L., Priolo, L., Perkan, A., Strana, M., Percuku, L., Berisha, G., Mziu, B., Beishenkulov, M., Abdurashidova, T., Toktosunova, A., Kaliev, K., Serpytis, R., Butkute, E., Lizaitis, M., Broslavskyte, M., Xuereb, R. G., Mercieca Balbi, M., Paris, E., Buttigieg, L., Musial, W., Dobrzycki, S., Dubicki, A., Kazimierczyk, E., Tycinska, A., Wojakowski, W., Kalanska-Lukasik, B., Ochala, A., Wanha, W., Dworowy, S., Sielski, J., Janion, M., Janion-Sadowska, A., Wojtasik-Bakalarz, J., Bryniarski, L., Peruga, J. Z., Jonczyk, M., Jankowski, L., Klecha, A., Michalowska, J., Brzezinski, M., Kozmik, T., Kowalczyk, T., Adamczuk, J., Maliszewski, M., Kuziemka, P., Plaza, P., Jaros, A., Pawelec, A., Sledz, J., Bartus, S., Zmuda, W., Bogusz, M., Wisnicki, M., Szastak, G., Adamczyk, M., Suska, M., Czunko, P., Opolski, G., Kochman, J., Tomaniak, M., Miernik, S., Paczwa, K., Witkowski, A., Opolski, M. P., Staruch, A. D., Kalarus, Z., Honisz, G., Mencel, G., Swierad, M., Podolecki, T., Marques, J., Azevedo, P., Pereira, M. A., Gaspar, A., Monteiro, S., Goncalves, F., Leite, L., Manuel Lopes Dos Santos, W., Amado, J., Pereira, D., Silva, B., Caires, G., Neto, M., Rodrigues, R., Correia, A., Freitas, D., Lourenco, A., Ferreira, F., Sousa, F., Portugues, J., Calvo, L., Almeida, F., Alves, M., Silva, A., Caria, R., Seixo, F., Militaru, C., Ionica, E., Istratoaie, O., Florescu, M., Lipnitckaia, E., Osipova, O., Konstantinov, S., Bukatov, V., Vinokur, T., Egorova, E., Nefedova, E., Levashov, S., Gorbunova, A., Redkina, M., Karaulovskaya, N., Bijieva, F., Babich, N., Smirnova, O., Filyanin, R., Eseva, S., Kutluev, A., Chlopenova, A., Shtanko, A., Kuppar, E., Shaekhmurzina, E., Ibragimova, M., Mullahmetova, M., Chepisova, M., Kuzminykh, M., Betkaraeva, M., Namitokov, A., Khasanov, N., Baleeva, L., Galeeva, Z., Magamedkerimova, F., Ivantsov, E., Tavlueva, E., Kochergina, A., Sedykh, D., Kosmachova, E., Skibitskiy, V., Porodenko, N., Litovka, K., Ulbasheva, E., Niculina, S., Petrova, M., Harkov, E., Tsybulskaya, N., Lobanova, A., Chernova, A., Kuskaeva, A., Kuskaev, A., Ruda, M., Zateyshchikov, D., Gilarov, M., Konstantinova, E., Koroleva, O., Averkova, A., Zhukova, N., Kalimullin, D., Borovkova, N., Tokareva, A., Buyanova, M., Khaisheva, L., Pirozhenko, A., Novikova, T., Yakovlev, A., Tyurina, T., Lapshin, K., Moroshkina, N., Kiseleva, M., Fedorova, S., Krylova, L., Duplyakov, D., Semenova, Y., Rusina, A., Ryabov, V., Syrkina, A., Demianov, S., Reitblat, O., Artemchuk, A., Efremova, E., Makeeva, E., Menzorov, M., Shutov, A., Klimova, N., Shevchenko, I., Elistratova, O., Kostyuckova, O., Islamov, R., Budyak, V., Ponomareva, E., Ullah Jan, U., Alshehri, A. 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N., Abdin Hussein, G., Butt, M., Markovic Nikolic, N., Obradovic, S., Djenic, N., Brajovic, M., Davidovic, A., Romanovic, R., Novakovic, V., Dekleva, M., Spasic, M., Dzudovic, B., Jovic, Z., Cvijanovic, D., Veljkovic, S., Ivanov, I., Cankovic, M., Jarakovic, M., Kovacevic, M., Trajkovic, M., Mitov, V., Jovic, A., Hudec, M., Gombasky, M., Sumbal, J., Bohm, A., Baranova, E., Kovar, F., Samos, M., Podoba, J., Kurray, P., Obona, T., Remenarikova, A., Kollarik, B., Verebova, D., Kardosova, G., Alusik, D., Macakova, J., Kozlej, M., Bayes-Genis, A., Sionis, A., Garcia Garcia, C., Duran Cambra, A., Labata Salvador, C., Rueda Sobella, F., Sans Rosello, J., Vila Perales, M., Oliveras Vila, T., Ferrer Massot, M., Baneras, J., Lekuona, I., Zugazabeitia, G., Fernandez-Ortiz, A., Viana Tejedor, A., Ferrera, C., Alvarez, V., DIaz-Castro, O., Agra-Bermejo, R. M., Gonzalez-Cambeiro, C., Gonzalez-Babarro, E., Domingo-Del Valle, J., Royuela, N., Burgos, V., Canteli, A., Castrillo, C., Cobo, M., Ruiz, M., Abu-Assi, E., and Garcia Acuna, J.

Subjects
Registrie, medicine.medical_specialty, medicine.medical_treatment, Cardiology, Myocardial Reperfusion, 030204 cardiovascular system & hematology, 03 medical and health sciences, Hospital, 0302 clinical medicine, Reperfusion therapy, Percutaneous Coronary Intervention, Internal medicine, Fibrinolysis, medicine, Humans, 030212 general & internal medicine, Myocardial infarction, Registries, Prospective Studies, Prospective cohort study, Observational studies, observational studies, reperfusion therapy, business.industry, Mortality rate, Primary percutaneous coronary intervention, ST-elevation myocardial infarction, Europe, Hospitals, Treatment Outcome, ST Elevation Myocardial Infarction, Percutaneous coronary intervention, medicine.disease, primary percutaneous coronary intervention, Observational studie, 3. Good health, Prospective Studie, Cohort, Conventional PCI, Cardiology and Cardiovascular Medicine, business, Human
Abstract

Aims The aim of this study was to determine the contemporary use of reperfusion therapy in the European Society of Cardiology (ESC) member and affiliated countries and adherence to ESC clinical practice guidelines in patients with ST-elevation myocardial infarction (STEMI). Methods and results Prospective cohort (EURObservational Research Programme STEMI Registry) of hospitalized STEMI patients with symptom onset Conclusions The use of reperfusion therapy for STEMI in the ESC member and affiliated countries was high. Primary PCI was the most frequently used treatment and associated total in-hospital mortality was below 5%. However, there was geographic variation in the use of primary PCI, which was associated with differences in in-hospital mortality.

Published
2021

14. Masses and Proton Separation Energies Obtained from Q α and Q p Measurements

Author

Davids, C. N., Woods, P. J., Batchelder, J. C., Bingham, C. R., Blumenthal, D. J., Brown, L. T., Busse, B. C., Carpenter, M. P., Conticchio, L. F., Davinson, T., Deboer, J., Freeman, S. J., Hamada, S., Henderson, D. J., Irvine, R. J., Janssens, R. V. F., Maier, H. J., Müller, L., Page, R. D., Penttilä, H. T., Poli, G. L., Seweryniak, D., Soramel, F., Toth, K. S., Walters, W. B., Zimmerman, B. E., Lunney, David, editor, Audi, Georges, editor, and Kluge, H.-Jürgen, editor

Published
2001
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15. Chloroplast genome assemblies and comparative analyses of commercially important Vaccinium berry crops

Author

Fahrenkrog, A. M. (Annette M.), Matsumoto, G. O. (Gabriel O.), Toth, K. (Katalin), Jokipii-Lukkari, S. (Soile), Salo, H. M. (Heikki M.), Häggman, H. (Hely), Benevenuto, J. (Juliana), Munoz, P. R. (Patricio R.), Fahrenkrog, A. M. (Annette M.), Matsumoto, G. O. (Gabriel O.), Toth, K. (Katalin), Jokipii-Lukkari, S. (Soile), Salo, H. M. (Heikki M.), Häggman, H. (Hely), Benevenuto, J. (Juliana), and Munoz, P. R. (Patricio R.)

Abstract

Vaccinium is a large genus of shrubs that includes a handful of economically important berry crops. Given the numerous hybridizations and polyploidization events, the taxonomy of this genus has remained the subject of long debate. In addition, berries and berry-based products are liable to adulteration, either fraudulent or unintentional due to misidentification of species. The availability of more genomic information could help achieve higher phylogenetic resolution for the genus, provide molecular markers for berry crops identification, and a framework for efficient genetic engineering of chloroplasts. Therefore, in this study we assembled five Vaccinium chloroplast sequences representing the economically relevant berry types: northern highbush blueberry (V. corymbosum), southern highbush blueberry (V. corymbosum hybrids), rabbiteye blueberry (V. virgatum), lowbush blueberry (V. angustifolium), and bilberry (V. myrtillus). Comparative analyses showed that the Vaccinium chloroplast genomes exhibited an overall highly conserved synteny and sequence identity among them. Polymorphic regions included the expansion/contraction of inverted repeats, gene copy number variation, simple sequence repeats, indels, and single nucleotide polymorphisms. Based on their in silico discrimination power, we suggested variants that could be developed into molecular markers for berry crops identification. Phylogenetic analysis revealed multiple origins of highbush blueberry plastomes, likely due to the hybridization events that occurred during northern and southern highbush blueberry domestication.

Published
2022

17. Discovery of a functionally selective ghrelin receptor (GHSR 1a ) ligand for modulating brain dopamine

Author

Gross, J. D., primary, Kim, D. W., additional, Zhou, Y., additional, Jansen, D., additional, Slosky, L. M., additional, Clark, N. B., additional, Ray, C. R., additional, Hu, X., additional, Southall, N., additional, Wang, A., additional, Xu, X., additional, Barnaeva, E., additional, Wetsel, W. C., additional, Ferrer, M., additional, Marugan, J. J., additional, Caron, M. G., additional, Barak, L. S., additional, and Toth, K., additional

Published
2022
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19. Empagliflozin in the treatment of heart failure with reduced ejection fraction in addition to background therapies and therapeutic combinations (EMPEROR-Reduced): a post-hoc analysis of a randomised, double-blind trial

Author

Verma, Subodh, primary, Dhingra, Nitish K, additional, Butler, Javed, additional, Anker, Stefan D, additional, Ferreira, Joao Pedro, additional, Filippatos, Gerasimos, additional, Januzzi, James L, additional, Lam, Carolyn S P, additional, Sattar, Naveed, additional, Peil, Barbara, additional, Nordaby, Matias, additional, Brueckmann, Martina, additional, Pocock, Stuart J, additional, Zannad, Faiez, additional, Packer, Milton, additional, Packer, M, additional, Anker, S, additional, Butler, J, additional, Filippatos, G, additional, Pocock, S, additional, Zannad, F, additional, Ferreira, JP, additional, Brueckmann, M, additional, George, J, additional, Jamal, W, additional, Welty, FK, additional, Palmer, M, additional, Clayton, T, additional, Parhofer, KG, additional, Pedersen, TR, additional, Greenberg, B, additional, Konstam, MA, additional, Lees, KR, additional, Carson, P, additional, Doehner, W, additional, Miller, A, additional, Haas, M, additional, Pehrson, S, additional, Komajda, M, additional, Anand, I, additional, Teerlink, J, additional, Rabinstein, A, additional, Steiner, T, additional, Kamel, H, additional, Tsivgoulis, G, additional, Lewis, J, additional, Freston, J, additional, Kaplowitz, N, additional, Mann, J, additional, Petrie, J, additional, Perrone, S, additional, Nicholls, S, additional, Janssens, S, additional, Bocchi, E, additional, Giannetti, N, additional, Verma, S, additional, Zhang, J, additional, Spinar, J, additional, Seronde, M-F, additional, Boehm, M, additional, Merkely, B, additional, Chopra, V, additional, Senni, M, additional, Taddi, S, additional, Tsutsui, H, additional, Choi, D-J, additional, Chuquiure, E, additional, La Rocca, HPB, additional, Ponikowski, P, additional, Juanatey, JRG, additional, Squire, I, additional, Januzzi, J, additional, Pina, I, additional, Bernstein, R, additional, Cheung, A, additional, Green, J, additional, Kaul, S, additional, Lam, C, additional, Lip, G, additional, Marx, N, additional, McCullough, P, additional, Mehta, C, additional, Rosenstock, J, additional, Sattar, N, additional, Scirica, B, additional, Shah, S, additional, Wanner, C, additional, Aizenberg, D, additional, Cartasegna, L, additional, Colombo Berra, F, additional, Colombo, H, additional, Fernandez Moutin, M, additional, Glenny, J, additional, Alvarez Lorio, C, additional, Anauch, D, additional, Campos, R, additional, Facta, A, additional, Fernandez, A, additional, Ahuad Guerrero, R, additional, Lobo Márquez, L, additional, Leon de la Fuente, RA, additional, Mansilla, M, additional, Hominal, M, additional, Hasbani, E, additional, Najenson, M, additional, Moises Azize, G, additional, Luquez, H, additional, Guzman, L, additional, Sessa, H, additional, Amuchástegui, M, additional, Salomone, O, additional, Perna, E, additional, Piskorz, D, additional, Sicer, M, additional, Perez de Arenaza, D, additional, Zaidman, C, additional, Nani, S, additional, Poy, C, additional, Resk, J, additional, Villarreal, R, additional, Majul, C, additional, Smith Casabella, T, additional, Sassone, S, additional, Liberman, A, additional, Carnero, G, additional, Caccavo, A, additional, Berli, M, additional, Budassi, N, additional, Bono, J, additional, Alvarisqueta, A, additional, Amerena, J, additional, Kostner, K, additional, Hamilton, A, additional, Begg, A, additional, Beltrame, J, additional, Colquhoun, D, additional, Gordon, G, additional, Sverdlov, A, additional, Vaddadi, G, additional, Wong, J, additional, Coller, J, additional, Prior, D, additional, Friart, A, additional, Leone, A, additional, Vervoort, G, additional, Timmermans, P, additional, Troisfontaines, P, additional, Franssen, C, additional, Sarens, T, additional, Vandekerckhove, H, additional, Van De Borne, P, additional, Chenot, F, additional, De Sutter, J, additional, De Vuyst, E, additional, Debonnaire, P, additional, Dupont, M, additional, Pereira Dutra, O, additional, Canani, LH, additional, Vieira Moreira, MdC, additional, de Souza, W, additional, Backes, LM, additional, Maia, L, additional, De Souza Paolino, B, additional, Manenti, ER, additional, Saporito, W, additional, Villaça Guimarães Filho, F, additional, Franco Hirakawa, T, additional, Saliba, LA, additional, Neuenschwander, FC, additional, de Freitas Zerbini, CA, additional, Gonçalves, G, additional, Gonçalves Mello, Y, additional, Ascenção de Souza, J, additional, Beck da Silva Neto, L, additional, Bocchi, EA, additional, Da Silveira, J, additional, de Moura Xavier Moraes Junior, JB, additional, de Souza Neto, JD, additional, Hernandes, M, additional, Finimundi, HC, additional, Sampaio, CR, additional, Vasconcellos, E, additional, Neves Mancuso, FJ, additional, Noya Rabelo, MM, additional, Rodrigues Bacci, M, additional, Santos, F, additional, Vidotti, M, additional, Simões, MV, additional, Gomes, FL, additional, Vieira Nascimento, C, additional, Precoma, D, additional, Helfenstein Fonseca, FA, additional, Ribas Fortes, JA, additional, Leães, PE, additional, Campos de Albuquerque, D, additional, Kerr Saraiva, JF, additional, Rassi, S, additional, Alves da Costa, FA, additional, Reis, G, additional, Zieroth, S, additional, Dion, D, additional, Savard, D, additional, Bourgeois, R, additional, Constance, C, additional, Anderson, K, additional, Leblanc, M-H, additional, Yung, D, additional, Swiggum, E, additional, Pliamm, L, additional, Pesant, Y, additional, Tyrrell, B, additional, Huynh, T, additional, Spiegelman, J, additional, Lavoie, J-P, additional, Hartleib, M, additional, Bhargava, R, additional, Straatman, L, additional, Virani, S, additional, Costa-Vitali, A, additional, Hill, L, additional, Heffernan, M, additional, Khaykin, Y, additional, Ricci, J, additional, Senaratne, M, additional, Zhai, A, additional, Lubelsky, B, additional, Toma, M, additional, Yao, L, additional, McKelvie, R, additional, Noronha, L, additional, Babapulle, M, additional, Pandey, A, additional, Curnew, G, additional, Lavoie, A, additional, Berlingieri, J, additional, Kouz, S, additional, Lonn, E, additional, Chehayeb, R, additional, Zheng, Y, additional, Sun, Y, additional, Cui, H, additional, Fan, Z, additional, Han, X, additional, Jiang, X, additional, Tang, Q, additional, Zhou, J, additional, Zheng, Z, additional, Zhang, X, additional, Zhang, N, additional, Zhang, Y, additional, Shen, A, additional, Yu, J, additional, Ye, J, additional, Yao, Y, additional, Yan, J, additional, Xu, X, additional, Wang, Z, additional, Ma, J, additional, Li, Y, additional, Li, S, additional, Lu, S, additional, Kong, X, additional, Song, Y, additional, Yang, G, additional, Yao, Z, additional, Pan, Y, additional, Guo, X, additional, Sun, Z, additional, Dong, Y, additional, Zhu, J, additional, Peng, D, additional, Yuan, Z, additional, Lin, J, additional, Yin, Y, additional, Jerabek, O, additional, Burianova, H, additional, Fiala, T, additional, Hubac, J, additional, Ludka, O, additional, Monhart, Z, additional, Vodnansky, P, additional, Zeman, K, additional, Foldyna, D, additional, Krupicka, J, additional, Podpera, I, additional, Busak, L, additional, Radvan, M, additional, Vomacka, Z, additional, Prosecky, R, additional, Cifkova, R, additional, Durdil, V, additional, Vesely, J, additional, Vaclavik, J, additional, Cervinka, P, additional, Linhart, A, additional, Brabec, T, additional, Miklik, R, additional, Bourhaial, H, additional, Olbrich, H-G, additional, Genth-Zotz, S, additional, Kemala, E, additional, Lemke, B, additional, Böhm, M, additional, Schellong, S, additional, Rieker, W, additional, Heitzer, T, additional, Ince, H, additional, Faghih, M, additional, Birkenfeld, A, additional, Begemann, A, additional, Ghanem, A, additional, Ujeyl, A, additional, von Haehling, S, additional, Dorsel, T, additional, Bauersachs, J, additional, Prull, M, additional, Weidemann, F, additional, Darius, H, additional, Nickenig, G, additional, Wilke, A, additional, Sauter, J, additional, Rauch-Kroehnert, U, additional, Frey, N, additional, Schulze, CP, additional, König, W, additional, Maier, L, additional, Menzel, F, additional, Proskynitopoulos, N, additional, Ebert, H-H, additional, Sarnighausen, H-E, additional, Düngen, H-D, additional, Licka, M, additional, Stellbrink, C, additional, Winkelmann, B, additional, Menck, N, additional, López-Sendón, JL, additional, de la Fuente Galán, L, additional, Delgado Jiménez, JF, additional, Manito Lorite, N, additional, Pérez de Juan Romero, M, additional, Galve Basilio, E, additional, Cereto Castro, F, additional, González Juanatey, JR, additional, Gómez, JJ, additional, Sanmartín Fernández, M, additional, Garcia-Moll Marimon, X, additional, Pascual Figal, D, additional, Bover Freire, R, additional, Bonnefoy Cudraz, E, additional, Jobbe Duval, A, additional, Tomasevic, D, additional, Habib, G, additional, Isnard, R, additional, Picard, F, additional, Khanoyan, P, additional, Dubois-Rande, J-L, additional, Galinier, M, additional, Roubille, F, additional, Alexandre, J, additional, Babuty, D, additional, Delarche, N, additional, Berneau, J-B, additional, Girerd, N, additional, Saxena, M, additional, Rosano, G, additional, Yousef, Z, additional, Clifford, C, additional, Arden, C, additional, Bakhai, A, additional, Boos, C, additional, Jenkins, G, additional, Travill, C, additional, Price, D, additional, Koenyves, L, additional, Lakatos, F, additional, Matoltsy, A, additional, Noori, E, additional, Zilahi, Z, additional, Andrassy, P, additional, Kancz, S, additional, Simon, G, additional, Sydo, T, additional, Vorobcsuk, A, additional, Kiss, RG, additional, Toth, K, additional, Szakal, I, additional, Nagy, L, additional, Barany, T, additional, Nagy, A, additional, Szolnoki, E, additional, Chopra, VK, additional, Mandal, S, additional, Rastogi, V, additional, Shah, B, additional, Mullasari, A, additional, Shankar, J, additional, Mehta, V, additional, Oomman, A, additional, Kaul, U, additional, Komarlu, S, additional, Kahali, D, additional, Bhagwat, A, additional, Vijan, V, additional, Ghaisas, NK, additional, Mehta, A, additional, Kashyap, J, additional, Kothari, Y, additional, TaddeI, S, additional, Scherillo, M, additional, Zacà, V, additional, Genovese, S, additional, Salvioni, A, additional, Fucili, A, additional, Fedele, F, additional, Cosmi, F, additional, Volpe, M, additional, Mazzone, C, additional, Esposito, G, additional, Doi, M, additional, Yamamoto, H, additional, Sakagami, S, additional, Oishi, S, additional, Yasaka, Y, additional, Tsuboi, H, additional, Fujino, Y, additional, Matsuoka, S, additional, Watanabe, Y, additional, Himi, T, additional, Ide, T, additional, Ichikawa, M, additional, Kijima, Y, additional, Koga, T, additional, Yuda, S, additional, Fukui, K, additional, Kubota, T, additional, Manita, M, additional, Fujinaga, H, additional, Matsumura, T, additional, Fukumoto, Y, additional, Kato, R, additional, Kawai, Y, additional, Hiasa, G, additional, Kazatani, Y, additional, Mori, M, additional, Ogimoto, A, additional, Inoko, M, additional, Oguri, M, additional, Kinoshita, M, additional, Okuhara, K, additional, Watanabe, N, additional, Ono, Y, additional, Otomo, K, additional, Sato, Y, additional, Matsunaga, T, additional, Takaishi, A, additional, Miyagi, N, additional, Uehara, H, additional, Takaishi, H, additional, Urata, H, additional, Kataoka, T, additional, Matsubara, H, additional, Matsumoto, T, additional, Suzuki, T, additional, Takahashi, N, additional, Imamaki, M, additional, Yoshitama, T, additional, Saito, T, additional, Sekino, H, additional, Furutani, Y, additional, Koda, M, additional, Shinozaki, T, additional, Hirabayashi, K, additional, Tsunoda, R, additional, Yonezawa, K, additional, Hori, H, additional, Yagi, M, additional, Arikawa, M, additional, Hashizume, T, additional, Ishiki, R, additional, Koizumi, T, additional, Nakayama, K, additional, Taguchi, S, additional, Nanasato, M, additional, Yoshida, Y, additional, Tsujiyama, S, additional, Nakamura, T, additional, Oku, K, additional, Shimizu, M, additional, Suwa, M, additional, Momiyama, Y, additional, Sugiyama, H, additional, Kobayashi, K, additional, Inoue, S, additional, Kadokami, T, additional, Maeno, K, additional, Kawamitsu, K, additional, Maruyama, Y, additional, Nakata, A, additional, Shibata, T, additional, Wada, A, additional, Cho, H-J, additional, Na, JO, additional, Yoo, B-S, additional, Choi, J-O, additional, Hong, SK, additional, Shin, J-H, additional, Cho, M-C, additional, Han, SH, additional, Jeong, J-O, additional, Kim, J-J, additional, Kang, SM, additional, Kim, D-S, additional, Kim, MH, additional, Llamas Esperon, G, additional, Illescas Díaz, J, additional, Fajardo Campos, P, additional, Almeida Alvarado, J, additional, Bazzoni Ruiz, A, additional, Echeverri Rico, J, additional, Lopez Alcocer, I, additional, Valle Molina, L, additional, Hernandez Herrera, C, additional, Calvo Vargas, C, additional, Padilla Padilla, FG, additional, Rodriguez Briones, I, additional, Chuquiure Valenzuela, EJJR, additional, Aguilera Real, ME, additional, Carrillo Calvillo, J, additional, Alpizar Salazar, M, additional, Cervantes Escárcega, JL, additional, Velasco Sanchez, R, additional, Al - Windy, N, additional, van Heerebeek, L, additional, Bellersen, L, additional, Brunner-La Rocca, H-P, additional, Post, J, additional, Linssen, GCM, additional, van de Wetering, M, additional, Peters, R, additional, van Stralen, R, additional, Groutars, R, additional, Smits, P, additional, Yilmaz, A, additional, Kok, WEM, additional, Van der Meer, P, additional, Dijkmans, P, additional, Troquay, R, additional, van Alem, AP, additional, Van de Wal, R, additional, Handoko, L, additional, Westendorp, ICD, additional, van Bergen, PFMM, additional, Rensing, BJWM, additional, Hoogslag, P, additional, Kietselaer, B, additional, Kragten, JA, additional, den Hartog, FR, additional, Alings, A, additional, Danilowicz-Szymanowicz, L, additional, Raczak, G, additional, Piesiewicz, W, additional, Zmuda, W, additional, Kus, W, additional, Podolec, P, additional, Musial, W, additional, Drelich, G, additional, Kania, G, additional, Miekus, P, additional, Mazur, S, additional, Janik, A, additional, Spyra, J, additional, Peruga, J, additional, Balsam, P, additional, Krakowiak, B, additional, Szachniewicz, J, additional, Ginel, M, additional, Grzybowski, J, additional, Chrustowski, W, additional, Wojewoda, P, additional, Kalinka, A, additional, Zurakowski, A, additional, Koc, R, additional, Debinski, M, additional, Fil, W, additional, Kujawiak, M, additional, Forys, J, additional, Kasprzak, M, additional, Krol, M, additional, Michalski, P, additional, Mirek-Bryniarska, E, additional, Radwan, K, additional, Skonieczny, G, additional, Stania, K, additional, Skoczylas, G, additional, Madej, A, additional, Jurowiecki, J, additional, Firek, B, additional, Wozakowska-Kaplon, B, additional, Cymerman, K, additional, Neutel, J, additional, Adams, K, additional, Balfour, P, additional, Deswal, A, additional, Djamson, A, additional, Duncan, P, additional, Hong, M, additional, Murray, C, additional, Rinde-Hoffman, D, additional, Woodhouse, S, additional, MacNevin, R, additional, Rama, B, additional, Broome-Webster, C, additional, Kindsvater, S, additional, Abramov, D, additional, Barettella, M, additional, Pinney, S, additional, Herre, J, additional, Cohen, A, additional, Vora, K, additional, Challappa, K, additional, West, S, additional, Baum, S, additional, Cox, J, additional, Jani, S, additional, Karim, A, additional, Akhtar, A, additional, Quintana, O, additional, Paukman, L, additional, Goldberg, R, additional, Bhatti, Z, additional, Budoff, M, additional, Bush, E, additional, Potler, A, additional, Delgado, R, additional, Ellis, B, additional, Dy, J, additional, Fialkow, J, additional, Sangrigoli, R, additional, Ferdinand, K, additional, East, C, additional, Falkowski, S, additional, Donahoe, S, additional, Ebrahimi, R, additional, Kline, G, additional, Harris, B, additional, Khouzam, R, additional, Jaffrani, N, additional, Jarmukli, N, additional, Kazemi, N, additional, Koren, M, additional, Friedman, K, additional, Herzog, W, additional, Silva Enciso, J, additional, Cheung, D, additional, Grover-McKay, M, additional, Hauptman, P, additional, Mikhalkova, D, additional, Hegde, V, additional, Hodsden, J, additional, Khouri, S, additional, McGrew, F, additional, Littlefield, R, additional, Bradley, P, additional, McLaurin, B, additional, Lupovitch, S, additional, Labin, I, additional, Rao, V, additional, Leithe, M, additional, Lesko, M, additional, Lewis, N, additional, Lombardo, D, additional, Mahal, S, additional, Malhotra, V, additional, Dauber, I, additional, Banerjee, A, additional, Needell, J, additional, Miller, G, additional, Paladino, L, additional, Munuswamy, K, additional, Nanna, M, additional, McMillan, E, additional, Mumma, M, additional, Napoli, M, additional, Nelson, W, additional, O'Brien, T, additional, Adlakha, A, additional, Onwuanyi, A, additional, Serota, H, additional, Schmedtje, J, additional, Paraschos, A, additional, Potu, R, additional, Sai-Sudhakar, C, additional, Saltzberg, M, additional, Sauer, A, additional, Shah, P, additional, Skopicki, H, additional, Bui, H, additional, Carr, K, additional, Stevens, G, additional, Tahirkheli, N, additional, Tallaj, J, additional, Yousuf, K, additional, Trichon, B, additional, Welker, J, additional, Tolerico, P, additional, Vest, A, additional, Vivo, R, additional, Wang, X, additional, Abadier, R, additional, Dunlap, S, additional, Weintraub, N, additional, Malik, A, additional, Kotha, P, additional, Zaha, V, additional, Kim, G, additional, Uriel, N, additional, Greene, T, additional, Salacata, A, additional, Arora, R, additional, Gazmuri, R, additional, Kobayashi, J, additional, Iteld, B, additional, Vijayakrishnan, R, additional, Dab, R, additional, Mirza, Z, additional, Marques, V, additional, Nallasivan, M, additional, Bensimhon, D, additional, Peart, B, additional, Saint-Jacques, H, additional, Barringhaus, K, additional, Contreras, J, additional, Gupta, A, additional, Koneru, S, additional, and Nguyen, V, additional

Published
2022
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23. Tenofovir DF/emtricitabine and efavirenz combination therapy for HIV infection in patients treated for tuberculosis: the ANRS 129 BKVIR trial

Author

Lortholary, Olivier, Roussillon, Caroline, Boucherie, Céline, Padoin, Christophe, Chaix, Marie-Laure, Breton, Guillaume, Rami, Agathe, Veziris, Nicolas, Patey, Olivier, Caumes, Eric, May, Thierry, Molina, Jean-Michel, Robert, Jérome, Tod, Michel, Fagard, Catherine, Chêne, Geneviève, Aumaître, H., Borsato, F., Malet, M., Médus, M., Moreau, L., Neuville, S., Saada, M., Abgrall, S., Ahoudji, D., Balmard, L., Bentata, M., Bouchaud, O., Boudribila, A., Cailhol, J., Dhote, R., Djebbar, R., Gros, H., Honoré, P., Huynh, T., Krivitzky, A., Mansouri, R., Pizzocolo, C., Rouges, F., Viot, E., Amar, B., Bantsimba, J., Dellion, S., Patey, O., Richier, L., Dupon, M., Dutronc, H., Neau, D., Ragnaud, J. M., Raymond, I., Boucly, S., Gailhoustet, L., Lortholary, O., Maignan, A., Touam, F., Viard, J. P., Bergmann, J. F., Boulanger, E., Delcey, V., Diemer, M., Durel, A., Jouade, F., Parrinello, M., Rami, A., Sellier, P., Brazille, P., Leclerc, C., Welker, Y., Bernard, L., Berthé, H., Perronne, C., Salomon, J., de Truchis, P., Bolliot, C., Couzigou, C., Derradji, O., Escaut, L., Teicher, E., Vittecoq, D., Chakvetadze, C., Fontaine, C., LʼYavanc, T., Maresca, A., Pialoux, G., Slama, L., Tuna, L., Bornarel, D., Boué, F., Chassaing, A., Chaiba-Berroukeche, L., Chambrin, V., Delavalle, A. M., Galanaud, P., Levy, A., Pignon, C., Bonnet, D., Ecobichon, J. L., Fournier, I., Fraquiero, G., Gerbe, J., Gervais, A., Guiyedi, V., Iordache, L., Joly, V., Klutse, P., Laurichesse, J. J., Leport, C., Onanga, M., Pahlaval, G., Phung, B. C., Ralaimazava, P., Yeni, P., Almasi, F., Basler, M., Benammar, N., Brunes, A., Guérin, C., Guillevin, L., Meddour, R., Salmon, D., Spiridon, G., Tahi, T., Bloch, M., Ferreira, C., Mahe, I., Manceron, V., Minozzi, C., Mortier, E., Simonpoli, A. M., Vinceneux, P., Zeng Ai, F., Chesnel, C., Dominguez, S., Jouve, P., Lascaux-Cametz, A. S., Lelièvre, J. D., Levy, Y., Melica, G., Sobel, A., Bentaleb, N., Blondin-Diop, A., Bonmarchand, M., Bossi, P., Brancon, C., Breton, G., Bricaire, F., Caby, F., Canestri, A., Clavel, C., Edeb, N., Herson, S., Iguertsira, M., Katlama, C., Kouadio, H., Lagarde, P., Lopez, J. L., Marguet, F., Martinez, V., Remidi, H., Simon, A., Souchon, J. F., Valantin, M. A., Bollens, D., Girard, P. M., Lagneau, J. L., Lefebvre, B., Mouchotte, R., Ouazene, Z., Sebire, M., Theveny-Christiany, A., Valin, N., Bourgarit, A., de Castro, N., Delgado, J., Ferret, S., Lascoux-Combe, C., Molina, J. M., Parlier, S., Pavie, J., Pintado, C., Ponscarme, D., Rachline, A., Sereni, D., Taulera, O., de Verdiere, C., Vincent, F., Bernard, N., Bonarek, M., Bonnet, F., Delaune, J., Lacoste, D., Louis, I., Malvy, D., Mercier, P., Morlat, P., Pertusa, M. C., Schottey, M., Chanteloube, N., Eden, A., Le Moing, V., Makilson, A., de Boever, C. Merle, Reynes, J., Turrière, C., Tramoni, C., Vidal, M., Anavena, C., Billaud, E., Biron, C., Bonnet, B., Bouchez, J., Boutoille, D., Brosseau, D., Brunct, C., Colas, M., Feuillebois, N., Hüe, H., Launay, E., le Houssine, P. Morineau, Raffi, F., Reliquet, V., Cua, E., Dellamonica, P., Durant, J., Rahelinirina, V., Arvieux, C., Chapplain, J. M., Fily, F., Labbay, E., Michelet, C., Morin, F., Peaucelle, C., Revest, M., Ratajczak, M., Souala, F., Tattevin, P., Thomas, R., Alvarez, M., Balsarin, F., Bonnet, E., Busato, F., Cuzin, L., Marche, D., Marchou, B., Massip, P., Obadia, M., Porte, L., Aissi, E., Ajana, F., Alcaraz, I., Baclet, V., Dubus, S., Gérard, Y., Guerroumi, H., Huleux, T., Lahouste, A., Marien, M. C., Melliez, H., Mouton, Y., Pennel, M. P., Valette, M., Viget, N., Yazdanpanah, Y., Bevilacqua, S., Boyer, L., Lecompte, T., Letranchant, L., May, T., Rabaud, C., Thomas, L., Vancon, R., Wassoumbou, S., Abboud, P., Borsa-Lebas, F., Caron, F., Debab, Y., Etienne, M., Faucon, M., Gueit, I., Brouqui, P., Mokhtari, S., Moreau, J., Schlojsers, M., Vandergheynst, E., Chousterman, M., Delacroix-Szmania, I., El Harrar, B., Garrait, V., Joannes, S., Luquet-Besson, I., Mouchet, M., Richier, L., Stevens, A. Blase, Dupont, C., Maresca, A. Freire, Greffe, S., Hanslik, T., Landi, B., Leporrier, J., Rouveix, E., Toth, K., El Mansouf, L., Khuong-Josses, M. A., Méchali, D., Le Besnerais, J. Phalip, Taverne, B., Barclay, F., Fain, O., Flexor, G., Stirnemann, J., Tassi, S., Levast, M., Rogeaux, O., Raffenot, D., Tous, J., Lortholary, O., Bouchaud, O., Chaix, M. L., Chêne, G., Couffin-Cadiergues, S., Dupon, M., Fagard, C., Joly, V., Launay, O., Molina, J. M., Robert, J., Roussillon, C., Rouzioux, C., Tod, M., Yazdanpanah, Y., Lortholary, O., Breton, G., Caumes, E., May, T., Roussillon, C., Veziris, N., Badets, M., Boucherie, C., Fagard, C., Chêne, G., Roussillon, C., Terras, N., Guérin, C., Altare, F., Bourgarit, A., Carcelain, G., Trylesinski, A., Aubron-Olivier, C., Nguyen, T., and Bennai, Y.

Published
2016
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27. LB783 Skin-tethered bifunctional antibodies for treatment of autoimmune and inflammatory skin diseases

Author

Mande, P., primary, Borthakur, S., additional, Rios, D., additional, Halvey, P., additional, Boisvert, A., additional, Rowe, M., additional, Cianci, M., additional, Agrawal, A., additional, Borah, M., additional, Viney, J., additional, Kis-Toth, K., additional, Higginson-Scott, N., additional, Otipoby, K.L., additional, and Mascanfroni, I., additional

Published
2021
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29. A somatic piRNA pathway regulates epithelial-to-mesenchymal transition of chick neural crest cells

Author

Galton R, Marianne E. Bronner, and Fejes-Toth K

Subjects
endocrine system, education.field_of_study, urogenital system, Somatic cell, Population, Neural tube, Neural crest, Piwi-interacting RNA, Biology, Embryonic stem cell, Cell biology, medicine.anatomical_structure, SOX2, medicine, Epithelial–mesenchymal transition, education
Abstract

In the metazoan germline, Piwi proteins play an essential regulatory role in maintenance of stemness and self-renewal by piRNA-mediated repression of transposable elements. To date, the activity of Piwi proteins and the piRNA pathway in vertebrates was believed to be confined to the gonads. Our results reveal expression of Piwil1 in a vertebrate somatic cell type, the neural crest–a migratory embryonic stem cell population. We show that Piwil1 is expressed at low levels throughout chick neural crest development, peaking just before neural crest cells undergo an epithelial-to-mesenchymal transition to leave the neural tube and migrate into the periphery. Importantly, loss of Piwil1 impedes neural crest emigration. Small RNA sequencing reveals somatic piRNAs with sequence signatures of an active ping pong loop. Coupled with Piwil1 knockout RNA-seq, our data suggest that Piwil1 regulates expression of the transposon derived gene ERNI in the chick dorsal neural tube, which in turn suppresses Sox2 expression to precisely control the timing of neural crest specification and emigration. Our work provides mechanistic insight into a novel function of the piRNA pathway as a regulator of somatic development in vertebrates.

Published
2021

44. AB0034 PD-1 AGONISM INHIBITS ACTIVATION OF PLASMACYTOID DENDRITIC CELLS

Author

Banerjee, I., primary, Edwards, L., additional, Halvey, P., additional, Alioto, S., additional, Cluckley, D., additional, Mitchell, C., additional, Cox, C., additional, Lurier, E., additional, Cianci, M., additional, Bengeri, S., additional, Borthakur, S., additional, Kis-Toth, K., additional, Higginson-Scott, N., additional, Viney, J., additional, and Otipoby, K. L., additional

Published
2021
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45. AB0282 SAFETY, TOLERABILITY AND SELECTIVE EXPANSION OF REGULATORY T CELLS BY A SINGLE DOSE OF THE NOVEL IL-2 MUTEIN PT101 IN A PHASE 1 STUDY IN HEALTHY VOLUNTEERS

Author

Sundy, J. S., primary, Otipoby, K. L., additional, Higginson-Scott, N., additional, Visweswaraiah, J., additional, Sampson, E., additional, Kis-Toth, K., additional, Monsef, A., additional, Petaipimol, P., additional, Essayan, D., additional, Cosenza, M. E., additional, Kakkar, R., additional, and Viney, J., additional

Published
2021
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47. AB0019 TREATMENT OF AUTOIMMUNE AND INFLAMMATORY SKIN DISEASES USING SKIN-TARGETING BIFUNCTIONAL ANTIBODIES: A LOCALIZED IMMUNOMODULATION APPROACH

Author

Borthakur, S., primary, Mande, P., additional, Rios, D., additional, Halvey, P., additional, Boisvert, A., additional, Rowe, M., additional, Agrawal, A., additional, Borah, M., additional, Cianci, M., additional, Viney, J. L., additional, Kis-Toth, K., additional, Otipoby, K. L., additional, Mascanfroni, I., additional, and Higginson-Scott, N., additional

Published
2021
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49. Rivaroxaban for thromboprophylaxis after hospitalization for medical illness

Author

Spyropoulos, A, Ageno, W, Albers, G, Elliott, C, Halperin, J, Hiatt, W, Maynard, G, Steg, P, Weitz, J, Suh, E, Spiro, T, Barnathan, E, Raskob, G, Douketis, J, Turpie, A, Schulman, S, Kearon, C, Linkins, L, Schellong, S, Bauer, K, Geerts, W, Roberts, R, Casais, P, Gallus, A, Karrasch, J, Eichinger-Hasenauer, S, Krivenchuk, V, Hadzovic-Dzuvo, A, Trbojevic, S, Lopes, R, Mincheva, V, Carrier, M, Dennis, R, Tudoric, N, Spinar, J, Nielsen, H, Marandi, T, Shaburishvili, T, Beyer-Westendorf, J, Vardas, P, Boda, Z, Brenner, B, Piovella, F, Krievins, D, Petrauskiene, B, Dejanova-Ilijevska, V, Virgen Carrillo, L, Middeldorp, S, Castillo Leon, R, Torbicki, A, Saraiva de Sousa, M, Dorobantu, M, Militaru, C, Yavelov, I, Vuckovic, B, Reuter, H, Basson, M, Monreal, M, Kucukoglu, S, Parkhomenko, A, Alikhan, R, Rosenberg, D, Yusen, R, Khorana, A, Tapson, V, Pollack, C, Hazelrigg, M, Jure, H, Alvarisqueta, A, Cartasegna, L, Hominal, M, Cursack, G, Alzogaray, M, Maillo, M, Parody, M, Caccavo, A, Dran, R, Muntaner, J, Casas, M, Schmidberg, J, Sarjanovich, R, Gabito, A, Garrido, M, Amuchastegui, M, Fernandez, A, Loureyro, J, Giumelli, C, Heazlewood, V, Colquhoun, D, White, H, Sabet, A, Bowler, S, Carroll, P, Khalafallah, A, Baker, R, Hedger, S, Simpson, F, Jackson, D, Chong, B, Siostrzonek, P, Gary, T, Hoppe, U, Dosta, N, Prystrom, A, Gorokhovsky, S, Yanushko, V, Skrahin, A, Kulik, A, Maslianski, B, Yakubtsevich, R, Timkin, I, Moguchaya, O, Tanaskovic, N, Miljkovic, S, Stojkovic, S, Kovacevic-Preradovic, T, Jovic, D, Basagic, E, Radjen, M, Mutapcic, M, Rizvanovic-Vojic, E, Galic, K, Terzic, I, Pojskic, B, Stevanovic, D, Cehajic, M, Rech, R, Annichino-Bizzacchi, J, Stelmach, R, Blanco, D, Castro, I, Backes, L, Saraiva, J, Ramacciotti, E, de Barros e Silva, P, Reis, G, Moreira Vieira, E, Leaes, P, Zimmermann, S, Van Bellen, B, Precoma, D, Luiz Silvestrini, T, Hernandes, M, Kyoleyan, M, Kalinova, T, Tiholov, R, Petrov, I, Mihov, A, Chompalova, B, Velikov, C, Pencheva, G, Atanasov, P, Raev, D, Kinova, E, Peltegov, V, Marchev, S, Siulemezova, S, Ayryanova, I, Grigorov, M, Naydenova, I, Koteva, N, Dimov, B, Runev, N, Getov, D, Metev, H, Donchev, K, Taseva, M, Hadzhieva, A, Benov, H, Stoyanov, M, Tisheva-Gospodinova, S, Mihaylova, N, Abadzhiev, S, Atzev, B, Georgiev, R, Mollov, M, Stoikov, A, Mazhdrakov, G, Karastanev, K, Dube, F, Roth, S, Mansour, S, Wu, C, Dolan, S, Pesant, Y, Pietrangelo, M, Dresser, G, Kahn, S, Kruisselbrink, R, Cadena Bonfanti, A, Botero, R, Quintero Ossa, A, Poveda, C, Cedano, J, Gomez Isaza, L, Villaquiran Torres, C, Gomez Mesa, J, Vargas Alonso, R, Espinosa, D, Rodriguez, J, Sanchez, G, Accini Mendoza, J, Gomez Florez, C, Cuervo Millan, F, Pesek, K, Horvat, D, Fuckar, K, Ruzic, A, Ostricki, B, Knezevic, A, Breitenfeld, T, Laganovic, M, Samodol, A, Sikic, J, Starcevic, B, Babic, Z, Samarzija, M, Milas, K, Votocek, S, Kvapil, M, Kolman, P, Bindas, P, Simon, V, Adamek, T, Svobodova, J, Gergely, L, Lastuvka, J, Macel, I, Navratil, K, Gregor, P, Lacnak, B, Janousek, J, Kellnerova, I, Hulinsky, V, Matusek, Z, Prucek, L, Dunaj, M, Pirchala, M, Vencour, D, Pavolko, M, Gorican, K, Fiksa, J, Tuxen, C, Meyer, C, Suppli Ulrik, C, Uuetoa, T, Otarishvili, N, Khintibidze, I, Emukhvari, N, Kipiani, Z, Gochitashvili, D, Mamatsashvili, M, Megreladze, I, Paposhvili, K, Agladze, R, Eradze, Z, Chelidze, K, Lominadze, S, Chukhrukidze, A, Chumburidze, V, Metreveli, S, Danelia, V, Orjonikidze, S, Kobulia, B, Nikolaishvili, G, Gvenetadze, R, Melia, A, Tsinamdzgvrishvili, B, Sekhniashvili, M, Sikharulidze, I, Meuser, M, Licka, M, Rauch-Kroehnert, U, Graf, K, Brachmann, J, Akin, I, Toumbis, M, Vassilikos, V, Konstantinides, S, Steiropoulos, P, Gogos, C, Andrikopoulos, G, Parthenakis, F, Karydi, P, Tsivgoulis, G, Mertzanos, G, Olympios, C, Karapanayiotides, T, Paraskevopoulou, E, Kifnidis, K, Hahalis, G, Skoutelis, A, Vadikolias, K, Nyirati, G, Nagy, L, Matoltsy, A, Komoly, S, Lippai, J, Kiss, K, Toth, K, Pozsegovits, K, Kiraly, C, Bereczki, D, Zolyomi, S, Szakal, I, Pall, D, Futo, L, Forster, T, Lovasz, O, Papp, A, Kiraly, Z, Pozsonyi, Z, Hajko, E, Kristof, P, Lakatos, F, Ples, Z, Kirschner, R, Lupkovics, G, Timar, G, Pinter, I, Kristof, T, Kis, E, Kovacs, A, Jakab, G, Palinkas, A, Muller, G, Turi, T, Horvath, C, Kondakor, I, Csanyi, A, Frankfurter, Z, Gurzo, M, Gafter-Gvili, A, Kuchuk, M, Azzam, Z, Elis, A, Halabi, M, Hussein, O, Blum, A, Tsoran-Rosenthal, I, Lishner, M, Hochberg-Klein, S, Caraco, Y, Atar, S, Elias, N, Gavish, D, Butnaru, A, Cosmi, F, Garbelotto, R, Giorgi Pierfranceschi, M, Simioni, L, Gronda, E, Pesci, A, D'Angelo, A, Fedele, F, Ghirarduzzi, A, Piovaccari, G, Lembo, G, Ria, L, Monaco, G, Brunelli, C, Tosetto, A, Capucci, A, Zanatta, N, Pistolesi, M, Mazzi, V, Testa, S, Scherillo, M, Di Biase, M, Antonicelli, R, Lodigiani, C, Nassiacos, D, Viksne, I, Lapkovska, Z, Rancane, G, Sime, I, Pontaga, N, Eglite, R, Puzule, S, Smolova, R, Butkiene, Z, Bagdonas, A, Raugaliene, R, Norkiene, S, Norviliene, R, Basijokiene, V, Stonkus, S, Griskeviciene, V, Miskiniene, A, Norvaisiene, R, Skripkauskiene, I, Jovkovska-Kaeva, B, Kochovska-Kamchevska, N, Antovski, A, Nechevska, L, Celeska, V, Ilievska-Poposka, B, Kostojchinoska, M, Donchovska, S, Kedev, S, Kuzmanovski, I, Bushletikj, O, Stojchev, S, Bakrachevski, N, Kuzmanovska, B, Angusheva, T, Llamas Esperon, G, Valdez Lopez, H, Medina Pech, C, Cortes Hernandez, M, Gans, S, Smulders, S, Swart, H, Boersma, W, Goosens, M, Hovens, M, Semplonius, G, Sohne, M, Lema Osores, J, Salas Perez, M, Rodriguez, A, Rios Oliva, C, Cotrina, R, Berrospi Argandona, P, Toce Yanez, L, Chavez Ayala, C, Mirek-Bryniarska, E, Goch, A, Skucha, W, Skorski, M, Miekus, P, Szyszka, A, Piotrowski, G, Gniot, J, Czerski, T, Debich, P, Zaluska, R, Bebenek, W, Wozakowska-Kaplon, B, Sciborski, R, Ilkowski, J, Wojnowski, P, Uscinska, E, Gaciong, Z, Bonek, R, Sobkowicz, B, Berkowski, P, Bejgier, K, Polonski, L, Kosior, D, Lata, S, Kolodziej, P, Gessek, J, Kachel, T, Talalaj, M, Musial, J, Lewczuk, J, Krysiak, W, Kucharski, L, Wysokinski, A, Minc, P, Martinez, J, Gregorio, T, Almeida, F, Monteiro, P, Stanciulescu, G, Mercea, C, Iosipescu, L, Ciobotaru, V, Crisu, D, Burca, M, Tudoran, M, Savu, A, Negrean, V, Cojocaru, C, Minescu, B, Popa, V, Blajan, D, Nastase-Melicovici, D, Fruntelata, A, Barbulescu, S, Lukinyh, L, Akhunova, S, Vishneva, E, Semenova, I, Nikolaev, K, Shaydyuk, O, Nilk, R, Shalnev, V, Apartsin, K, Goloshchekin, B, Shpagina, L, Khlevchuk, T, Arkhipov, M, Malygin, A, Shvarts, Y, Khaisheva, L, Popov, D, Kobalava, Z, Lipchenko, A, Shapovalova, Y, Zrazhevsky, K, Greshnova, I, Maslova, N, Karabenenko, A, Shogenov, Z, Budankova, E, Barbarash, O, Uspenskiy, Y, Kosmacheva, E, Berns, S, Kostenko, V, Zateyshchikov, D, Vishnevsky, A, Boldueva, S, Podzolkov, V, Sergeeva, E, Grinshtein, Y, Khrustalev, O, Bugrova, O, Repin, A, Andreev, D, Petrovic, P, Boskovic Matic, T, Apostolovic, S, Lazic, Z, Stankovic, D, Stankovic, A, Mitov, V, Sofronic, D, Kopitovic, I, Zdravkovic, V, Joksimovic, Z, Lazovic, N, Petrovic-Stanojevic, N, Ilic, A, Vujadinovic, O, Pencic-Popovic, B, Andjelkovic, N, Sekularac, N, Hinic, S, Radjen, G, Zivkovic, A, Putnikovic, B, Ivanov, I, Babic, R, Van Zyl, L, Hobson, B, Engelbrecht, J, Mitha, I, Siebert, H, Jacobson, B, Breedt, J, Prozesky, H, Ntsekhe, M, Bayat, J, Ellis, G, Tarr, G, Adler, D, Van Dyk, C, Ismail, S, Spargo, C, Abdool-Gaffar, M, Saaiman, J, Venter, K, Lorente Aroca, M, Fernandez Portales, F, Pedrajas Navas, J, Rodriguez Botaro, A, Santa Cruz Siminiani, A, Lopez Reyes, R, Bisbe i Company, J, Piedecausa Selfa, M, Velasco Garrido, J, Sobrino-Martinez, J, Munoz Delgado, G, Sala Llinas, E, Blanco Coronado, J, Almenar Bonet, L, Vida Gutierrez, M, Sanchez Lora, F, Sanchez Martinez, R, Calderon, E, Villalta Blanch, J, De la Hera Galarza, J, Bustamante Ruiz, A, Garcia-Fuster, M, Ripoll Vera, T, Alvarez-Sala Walter, L, Todoli Parra, J, Diaz Fernandez, J, Bosa Ojeda, F, Pellicer-Ciscar, C, Jara Palomares, L, Quiles Granado, J, Trigo 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C., Ageno W., Albers G. W., Elliott C. G., Halperin J. L., Hiatt W. R., Maynard G. A., Steg P. G., Weitz J. I., Suh E., Spiro T. E., Barnathan E. S., Raskob G. E., Douketis J., Turpie A. G., Schulman S., Kearon C., Linkins L. A., Schellong S., Bauer K., Geerts W., Roberts R., Casais P., Gallus A., Karrasch J., Eichinger-Hasenauer S., Krivenchuk V., Hadzovic-Dzuvo A., Trbojevic S., Lopes R., Mincheva V., Carrier M., Dennis R., Tudoric N., Spinar J., Nielsen H., Marandi T., Shaburishvili T., Beyer-Westendorf J., Vardas P., Boda Z., Brenner B., Piovella F., Krievins D., Petrauskiene B., Dejanova-Ilijevska V., Virgen Carrillo L. R., Middeldorp S., Castillo Leon R. P., Torbicki A., Saraiva de Sousa M., Dorobantu M., Militaru C., Yavelov I., Vuckovic B., Reuter H., Basson M., Monreal M., Kucukoglu S., Parkhomenko A., Alikhan R., Rosenberg D., Yusen R., Khorana A., Tapson V., Pollack C., Hazelrigg M., Jure H., Alvarisqueta A., Cartasegna L., Hominal M., Cursack G., Alzogaray M., Maillo M., Parody M., Caccavo A., Dran R. D., Muntaner J. A., Casas M., Schmidberg J., Sarjanovich R., Gabito A., Garrido M., Amuchastegui M., Fernandez A., Loureyro J., Giumelli C., Heazlewood V., Colquhoun D., White H., Sabet A., Bowler S., Carroll P., Khalafallah A., Baker R., Hedger S., Simpson F. G., Jackson D., Chong B., Siostrzonek P., Gary T., Hoppe U., Dosta N., Prystrom A., Gorokhovsky S., Yanushko V., Skrahin A., Kulik A., Maslianski B., Yakubtsevich R., Timkin I., Moguchaya O., Tanaskovic N., Miljkovic S., Stojkovic S., Kovacevic-Preradovic T., Jovic D., Basagic E., Radjen M., Mutapcic M., Rizvanovic-Vojic E., Galic K., Terzic I., Pojskic B., Stevanovic D., Cehajic M., Rech R., Annichino-Bizzacchi J., Stelmach R., Blanco D., Castro I., Backes L. M., Saraiva J. F., Ramacciotti E., de Barros e Silva P. G. M., Reis G., Moreira Vieira E., Leaes P., Zimmermann S., Van Bellen B., Precoma D., Luiz Silvestrini T., Hernandes M. E., Kyoleyan M., Kalinova T., Tiholov R., Petrov I., Mihov A., Chompalova B., Velikov C., Pencheva G., Atanasov P., Raev D., Kinova E., Peltegov V., Marchev S., Siulemezova S., Ayryanova I. D., Grigorov M., Naydenova I., Koteva N., Dimov B., Runev N., Getov D., Metev H., Donchev K., Taseva M., Hadzhieva A., Benov H., Stoyanov M., Tisheva-Gospodinova S., Mihaylova N., Abadzhiev S., Atzev B., Georgiev R., Mollov M., Stoikov A., Mazhdrakov G., Karastanev K., Dube F., Roth S., Mansour S., Wu C., Dolan S., Pesant Y., Pietrangelo M., Dresser G., Kahn S., Kruisselbrink R., Cadena Bonfanti A., Botero R., Quintero Ossa A., Poveda C. M., Cedano J., Gomez Isaza L., Villaquiran Torres C., Gomez Mesa J., Vargas Alonso R., Espinosa D., Rodriguez J. M., Sanchez G., Accini Mendoza J. L., Gomez Florez C. C., Cuervo Millan F., Pesek K., Horvat D., Fuckar K., Ruzic A., Ostricki B., Knezevic A., Breitenfeld T., Laganovic M., Samodol A., Sikic J., Starcevic B., Babic Z., Samarzija M., Milas K., Votocek S., Kvapil M., Kolman P., Bindas P., Simon V., Adamek T., Svobodova J., Gergely L., Lastuvka J., Macel I., Navratil K., Gregor P., Lacnak B., Janousek J., Kellnerova I., Hulinsky V., Matusek Z., Prucek L., Dunaj M., Pirchala M., Vencour D., Pavolko M., Gorican K., Fiksa J., Tuxen C., Meyer C., Suppli Ulrik C., Uuetoa T., Otarishvili N., Khintibidze I., Emukhvari N., Kipiani Z., Gochitashvili D., Mamatsashvili M., Megreladze I., Paposhvili K., Agladze R., Eradze Z., Chelidze K., Lominadze S., Chukhrukidze A., Chumburidze V., Metreveli S., Danelia V., Orjonikidze S., Kobulia B., Nikolaishvili G., Gvenetadze R., Melia A., Tsinamdzgvrishvili B., Sekhniashvili M., Sikharulidze I., Meuser M., Licka M., Rauch-Kroehnert U., Graf K., Brachmann J., Akin I., Toumbis M., Vassilikos V., Konstantinides S., Steiropoulos P., Gogos C., Andrikopoulos G., Parthenakis F., Karydi P., Tsivgoulis G., Mertzanos G., Olympios C., Karapanayiotides T., Paraskevopoulou E., Kifnidis K., Hahalis G., Skoutelis A., Vadikolias K., Nyirati G., Nagy L., Matoltsy A., Komoly S., Lippai J., Kiss K., Toth K., Pozsegovits K., Kiraly C., Bereczki D., Zolyomi S., Szakal I., Pall D., Futo L., Forster T., Lovasz O., Papp A., Kiraly Z., Pozsonyi Z., Hajko E., Kristof P., Lakatos F., Ples Z., Kirschner R., Lupkovics G., Timar G., Pinter I., Kristof T., Kis E., Kovacs A., Jakab G., Palinkas A., Muller G., Turi T., Horvath C., Kondakor I., Csanyi A., Frankfurter Z., Gurzo M., Gafter-Gvili A., Kuchuk M., Azzam Z., Elis A., Halabi M., Hussein O., Blum A., Tsoran-Rosenthal I., Lishner M., Hochberg-Klein S., Caraco Y., Atar S., Elias N., Gavish D., Butnaru A., Cosmi F., Garbelotto R., Giorgi Pierfranceschi M., Simioni L., Gronda E., Pesci A., D'Angelo A., Fedele F., Ghirarduzzi A., Piovaccari G., Lembo G., Ria L., Monaco G. L., Brunelli C., Tosetto A., Capucci A., Zanatta N., Pistolesi M., Mazzi V., Testa S., Scherillo M., Di Biase M., Antonicelli R., Lodigiani C., Nassiacos D., Viksne I., Lapkovska Z., Rancane G., Sime I., Pontaga N., Eglite R., Puzule S., Smolova R., Butkiene Z., Bagdonas A., Raugaliene R., Norkiene S., Norviliene R., Basijokiene V., Stonkus S., Griskeviciene V., Miskiniene A., Norvaisiene R., Skripkauskiene I., Jovkovska-Kaeva B., Kochovska-Kamchevska N., Antovski A., Nechevska L., Celeska V., Ilievska-Poposka B., Kostojchinoska M., Donchovska S., Kedev S., Kuzmanovski I., Bushletikj O., Stojchev S., Bakrachevski N., Kuzmanovska B., Angusheva T., Llamas Esperon G., Valdez Lopez H., Medina Pech C., Cortes Hernandez M., Virgen Carrillo L., Gans S., Smulders S., Swart H., Boersma W., Goosens M., Hovens M., Semplonius G., Sohne M., Lema Osores J., Salas Perez M. D., Rodriguez A., Rios Oliva C., Cotrina R., Berrospi Argandona P., Toce Yanez L., Chavez Ayala C., Mirek-Bryniarska E., Goch A., Skucha W., Skorski M., Miekus P., Szyszka A., Piotrowski G., Gniot J., Czerski T., Debich P., Zaluska R., Bebenek W., Wozakowska-Kaplon B., Sciborski R., Ilkowski J., Wojnowski P., Uscinska E., Gaciong Z., Bonek R., Sobkowicz B., Berkowski P., Bejgier K., Polonski L., Kosior D., Lata S., Kolodziej P., Gessek J., Kachel T., Talalaj M., Musial J., Lewczuk J., Krysiak W., Kucharski L., Wysokinski A., Minc P., Martinez J., Gregorio T., Almeida F., Monteiro P., Stanciulescu G., Mercea C. D., Iosipescu L. C., Ciobotaru V., Crisu D., Burca M., Tudoran M., Savu A., Negrean V., Cojocaru C., Minescu B., Popa V., Blajan D., Nastase-Melicovici D., Fruntelata A., Barbulescu S., Lukinyh L., Akhunova S., Vishneva E., Semenova I., Nikolaev K. Y., Shaydyuk O., Nilk R., Shalnev V., Apartsin K., Goloshchekin B. 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C., Cuervo Millan F., Pesek K., Horvat D., Fuckar K., Ruzic A., Ostricki B., Knezevic A., Breitenfeld T., Laganovic M., Samodol A., Sikic J., Starcevic B., Babic Z., Samarzija M., Milas K., Votocek S., Kvapil M., Kolman P., Bindas P., Simon V., Adamek T., Svobodova J., Gergely L., Lastuvka J., Macel I., Navratil K., Gregor P., Lacnak B., Janousek J., Kellnerova I., Hulinsky V., Matusek Z., Prucek L., Dunaj M., Pirchala M., Vencour D., Pavolko M., Gorican K., Fiksa J., Tuxen C., Meyer C., Suppli Ulrik C., Uuetoa T., Otarishvili N., Khintibidze I., Emukhvari N., Kipiani Z., Gochitashvili D., Mamatsashvili M., Megreladze I., Paposhvili K., Agladze R., Eradze Z., Chelidze K., Lominadze S., Chukhrukidze A., Chumburidze V., Metreveli S., Danelia V., Orjonikidze S., Kobulia B., Nikolaishvili G., Gvenetadze R., Melia A., Tsinamdzgvrishvili B., Sekhniashvili M., Sikharulidze I., Meuser M., Licka M., Rauch-Kroehnert U., Graf K., Brachmann J., Akin I., Toumbis M., Vassilikos V., Konstantinides S., Steiropoulos P., Gogos C., Andrikopoulos G., Parthenakis F., Karydi P., Tsivgoulis G., Mertzanos G., Olympios C., Karapanayiotides T., Paraskevopoulou E., Kifnidis K., Hahalis G., Skoutelis A., Vadikolias K., Nyirati G., Nagy L., Matoltsy A., Komoly S., Lippai J., Kiss K., Toth K., Pozsegovits K., Kiraly C., Bereczki D., Zolyomi S., Szakal I., Pall D., Futo L., Forster T., Lovasz O., Papp A., Kiraly Z., Pozsonyi Z., Hajko E., Kristof P., Lakatos F., Ples Z., Kirschner R., Lupkovics G., Timar G., Pinter I., Kristof T., Kis E., Kovacs A., Jakab G., Palinkas A., Muller G., Turi T., Horvath C., Kondakor I., Csanyi A., Frankfurter Z., Gurzo M., Gafter-Gvili A., Kuchuk M., Azzam Z., Elis A., Halabi M., Hussein O., Blum A., Tsoran-Rosenthal I., Lishner M., Hochberg-Klein S., Caraco Y., Atar S., Elias N., Gavish D., Butnaru A., Cosmi F., Garbelotto R., Giorgi Pierfranceschi M., Simioni L., Gronda E., Pesci A., D'Angelo A., Fedele F., Ghirarduzzi A., Piovaccari G., Lembo G., Ria L., Monaco G. L., Brunelli C., Tosetto A., Capucci A., Zanatta N., Pistolesi M., Mazzi V., Testa S., Scherillo M., Di Biase M., Antonicelli R., Lodigiani C., Nassiacos D., Viksne I., Lapkovska Z., Rancane G., Sime I., Pontaga N., Eglite R., Puzule S., Smolova R., Butkiene Z., Bagdonas A., Raugaliene R., Norkiene S., Norviliene R., Basijokiene V., Stonkus S., Griskeviciene V., Miskiniene A., Norvaisiene R., Skripkauskiene I., Jovkovska-Kaeva B., Kochovska-Kamchevska N., Antovski A., Nechevska L., Celeska V., Ilievska-Poposka B., Kostojchinoska M., Donchovska S., Kedev S., Kuzmanovski I., Bushletikj O., Stojchev S., Bakrachevski N., Kuzmanovska B., Angusheva T., Llamas Esperon G., Valdez Lopez H., Medina Pech C., Cortes Hernandez M., Virgen Carrillo L., Gans S., Smulders S., Swart H., Boersma W., Goosens M., Hovens M., Semplonius G., Sohne M., Lema Osores J., Salas Perez M. D., Rodriguez A., Rios Oliva C., Cotrina R., Berrospi Argandona P., Toce Yanez L., Chavez Ayala C., Mirek-Bryniarska E., Goch A., Skucha W., Skorski M., Miekus P., Szyszka A., Piotrowski G., Gniot J., Czerski T., Debich P., Zaluska R., Bebenek W., Wozakowska-Kaplon B., Sciborski R., Ilkowski J., Wojnowski P., Uscinska E., Gaciong Z., Bonek R., Sobkowicz B., Berkowski P., Bejgier K., Polonski L., Kosior D., Lata S., Kolodziej P., Gessek J., Kachel T., Talalaj M., Musial J., Lewczuk J., Krysiak W., Kucharski L., Wysokinski A., Minc P., Martinez J., Gregorio T., Almeida F., Monteiro P., Stanciulescu G., Mercea C. D., Iosipescu L. C., Ciobotaru V., Crisu D., Burca M., Tudoran M., Savu A., Negrean V., Cojocaru C., Minescu B., Popa V., Blajan D., Nastase-Melicovici D., Fruntelata A., Barbulescu S., Lukinyh L., Akhunova S., Vishneva E., Semenova I., Nikolaev K. Y., Shaydyuk O., Nilk R., Shalnev V., Apartsin K., Goloshchekin B. 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P., Gazmuri R., Kastelic R., Martinez R., Laman D., Macchiavelli A., Kmetzo J., Thurm C., Kayembe T., Chandrashekhar Y., Bassetti D., Jaoude P., Williams H., Dewhurst R., Naqvi S., Burr J., Rodriguez-Cintron W., Jeanfreau R., Kosinski E., Ndukwu I. M., Sotolongo C., Daboul N., Wilmer C., Simon P., Tak T., Rees C., Gupta N., Lerner R., Graffagnino C., Reed R. M., Alford C. M., Mody F., Wellmon B., Hamroff G., Rajan R., and Kaatz S.

Abstract

BACKGROUND Patients who are hospitalized for medical illness remain at risk for venous thromboembolism after discharge, but the role of extended thromboprophylaxis in the treatment of such patients is a subject of controversy. METHODS In this randomized, double-blind trial, medically ill patients who were at increased risk for venous thromboembolism on the basis of a modified International Medical Prevention Registry on Venous Thromboembolism (IMPROVE) score of 4 or higher (scores range from 0 to 10, with higher scores indicating a higher risk of venous thromboembolism) or a score of 2 or 3 plus a plasma d-dimer level of more than twice the upper limit of the normal range (defined according to local laboratory criteria) were assigned at hospital discharge to either once-daily rivaroxaban at a dose of 10 mg (with the dose adjusted for renal insufficiency) or placebo for 45 days. The primary efficacy outcome was a composite of symptomatic venous thromboembolism or death due to venous thromboembolism. The principal safety outcome was major bleeding. RESULTS Of the 12,024 patients who underwent randomization, 12,019 were included in the intention-to-treat analysis. The primary efficacy outcome occurred in 50 of 6007 patients (0.83%) who were given rivaroxaban and in 66 of 6012 patients (1.10%) who were given placebo (hazard ratio, 0.76; 95% confidence interval [CI], 0.52 to 1.09; P = 0.14). The prespecified secondary outcome of symptomatic nonfatal venous thromboembolism occurred in 0.18% of patients in the rivaroxaban group and 0.42% of patients in the placebo group (hazard ratio, 0.44; 95% CI, 0.22 to 0.89). Major bleeding occurred in 17 of 5982 patients (0.28%) in the rivaroxaban group and in 9 of 5980 patients (0.15%) in the placebo group (hazard ratio, 1.88; 95% CI, 0.84 to 4.23). CONCLUSIONS Rivaroxaban, given to medical patients for 45 days after hospital discharge, was not associated with a significantly lower risk of symptomatic venous thromboembolism and death

Published
2018

50. Poster abstracts

Author

Marshall, N. S., Almqvist, C., Grunstein, R. R., Marks, G. B., Nixon, G. M., Wawruszak, M., Verginis, N., Horne, R. S. C., Davey, M. J., Blunden, S. L., Chervin, R. D., Ng, M. L., O’Driscoll, D. M., Yang, J. S. C., Noa, A. M., Lushington, K., Camfferman, D., Gold, M., Kennedy, D., Galland, B. C., Taylor, B. J., Tripp, E. G., Phillips, A. M., Lrichardson, H., Verbeek, M., Parslow, P., Scott, S., Walker, A. M., Harding, R., Richards, H., Lack, L., Gradisar, M., Harris, J., Vu, T., Mitchell, P. I., Toth, K. A., Mcculloch, B. J., Campbell, A., Signal, T. L., O’Keeffe, K., Kanbayashi, T., Kondo, H., Satoh, S., Takemura, T., Kaneko, Y., Kanayama, H., Abe, M., Nishino, S., Ishikawa, H., Shimizu, T., Stadler, D., Catcheside, P., George, K., Thompson, C., Ryan, M., Mcevoy, R. D., Wilkinson, V., Nicholas, C., Worsnop, C., Jordan, A., Malhotra, A., Steiner, K., White, D., Trinder, J., Hellgren, J., Lee, Y., O’Brien, D., Yee, B., Rimmer, J., Grunstein, R., Hilditch, C. J., Catcheside, P. G., Rischmueller, M., Kirkness, J. P., Schneider, H., Patil, S. P., Mcginley, B. M., Smith, P. L., Schwartz, A. R., Maddison, K. J., Walsh, J. H., Philippe, D. L., Platt, P. R., Hillman, D. R., Eastwood, P. R., Yeo, A., Thomson, K., Melehan, K. L., Bartlett, D. J., Wong, K. K., Car, G., Feenstra, J. F. E., Eckert, B., Rixon, K., Hukins, C., Crummy, F., Kossmann, T., Cameron, P., Naughton, M. T., Larby, J. R., Curtin, D., Semple, K., Douglas, J., Lee, Y. H., Edwards, N., Sullivan, C. E., Lehman, S., Antic, N. A., Mcevoy, D., Mukherjee, S., Fedson, A., Palmer, L. J., Love, G., Singh, B., James, A., Cullen, S. C., Mcardle, N., Hillman, D., Clarke, P. F., Van Eps, C., Hawley, C., Lee, R. W., Chan, A. S., Cistulli, P. A., Abdul Latif, H., Stick, S., Maul, J., Wilson, A., Suresh, S., James, J., Byrne, S., Doull, I., Evans, H., Parsley, C. L., Williams, G., Dakin, C., Harris, M., Cooper, D. M., Heussler, H., Chan, E. Y.-T., Hyde, M. L., Yuill, M., Harris, M. A., Schibler, A., Wilson, S., Cooper, D., Maclean, J. E., Fitzsimons, D., Waters, K., Fitzgerald, D., Coussens, S., Berryman, M., Parsons, D., Saint, D., Pamula, Y., Martin, A. J., Abbot, D., Piper, A. J., Wang, D., Yee, B. J., Willson, G. N., Flunt, D., Bassin, D., Bateman, P., Ratnavadivel, R., Lester, S., Huang, Q. R., He, H. X., Chow, C. M., Jones, A. C., Visvalingam, V. V., Lui, P., Buchanan, P., Duce, B. L., Bliss, R. A., Bruck, D., Afaghi, A., O’Connor, H., Smith, S. S., Kilby, S., Jorgensen, G., Douglas, J. A., Johns, M. W., Tucker, A. J., Chapman, R. J., Michael, N. J., Beale, C. A., Stephens, M. N., Ferguson, S. A., Lamond, N., Jay, S. M., Dorrian, J., Jones, C. B., Roach, G. D., Dawson, D., Jackson, M. L., Howard, M. E., Kennedy, G., Swann, P., Pierce, R. J., Loughran, S. P., Wood, A. W., Croft, R. J., Barton, J. M., Thompson, B., Stough, C., Kandelaars, K., Warman, G. R., Bolton, C. A., Fernando, III, A. T., Cheeseman, J. F., Inglis, C., Huang, H.-C. C., Wlee, R., Richards, D., Turton, A., Copland, J., Ho, M., Rochford, P. D., Brazzale, D. J., Zubrinich, C., Roebuck, T. J., Toman, P., Ho, S., Szollosi, I., Naughton, M., Ruehland, W., Churchward, T., Ruehland, W. R., Churchward, T. J., Barnes, M., Lakey, T., Denotti, A. L., Dungan, G. C., Wong, K. K. H., Gilholme, J. W., Cunnington, D., Cherry, G., Teichtahl, H., Mietus, J. E., Goldberger, A. L., Thomas, R. J., Linklater, S., Martin, J., Galilogadr, S., Mihai, R., Gulliver, T., Wales, P., Salvini, A., Whitehead, B., Laybutt, N., Latham-Smith, F., Shine, N. P., Coates, H. L., Lannigan, F. J., Ng, A. T., Darendeliler, M. A., Zeng, B., Ng, A., Darendeliler, A., Cistulli, P., Qian, J., Hanssen, K., Schnider, H., Lewis, R. H., De Fazio, D., Pierce, R., Pretto, J., Mcdonald, C., Howard, M., Baulk, S. D., Biggs, S. N., Van Den Heuvel, C. J., Reid, K., Vakulin, A., Anderson, R., Banks, S., Davies, A. N., Williams, A. D., Almond, J., Beard, D., Peisker, C., Ball, M., Taylor, A., Wright, H., Clark, R., Hensley, M., Rowland, S., Windler, S., Kennedy, G. A., Gullo, M., Clarke, C., Gain, K., Murphy, M., Rebus, C., Saunders, K., Imazu, M., Morgan, H., Kwan, M., Nicholls, G., Tolson, J., Worsnop, C. J., Navin, C., Baker, G., and Van Der Touw, T.

Published
2006
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