Search

WOS: 000367181000001 PubMed: 26985328 Ovaries are the female organs that age more quickly than other tissues such as the uterus, the pituitary gland or pancreas. Different from males, an interesting question is why and how the females lose fertility so rapidly. During the aging process, both the number and quality of the oocytes in the ovaries decrease and reach to a point beyond that no more viable offspring may be produced and the associated cyclic endocrinological activities cease, entering the menopause in females at an average age of 50 years. Females who delayed childbearing with or without their willing until their 30 years or 40 years constitute the largest portion of the total infertility population. Ovarian reserve tests (ORTs) provide an indirect estimate of a female's diminishing ovarian reserve or remaining follicular pool. This article briefly reviews recent progresses in relation to ovarian aging and ORTs.

WOS: 000379157300158 We evaluated the bacterial profiles and antibiotic sensitivities presenting in each trimester of pregnant women diagnosed with lower urinary tract infection. Escherichia coli was the most common isolated uropathogen (77.8%, 75%, and 52%, respectively), followed by Klebsiella pneumoniae (0%, 3.6%, and 16%, respectively), and Enterococcus faecalis (3.7%, 14.3%, and 8%, respectively). Ciprofloxacin was found to have sensitivity for all uropathogens, with 92.8% sensitivity for Escherichia coli and 100% for Klebsiella pneumoniae. Norfloxacin also exhibited high sensitivity for almost all bacterial agents, except Acinetobacter baumannii, with 91.4% sensitivity for Escherichia coli and 100% for Klebsiella pneumoniae. Phosphomycin had the highest sensitivity, 100%, for the two most common uropathogens, Escherichia coli and Klebsiella pneumoniae. Because empirical antimicrobial choices play a critical role in the prevention of unwanted complications, lower urinary tract infection in pregnancy can be treated with empirically selected phosphomycin.

The aim of this study was to evaluate the validity of platelet count (PC) and indices, including mean platelet volume (MPV), platelet distribution width (PDW) and platelet crit (PCT), in identifying the pregnancies at risk for preeclampsia. Demographic data and laboratory tests for PC, MPV, PDW and PCT of 250 pregnant women (100 normotensive pregnants, 121 pregnants with severe preeclampsia and 29 pregnants with mild preeclampsia) were retrospectively analyzed. Platelet counts and indices were compared between the study groups. MPV and PDW were significantly higher in preeclamptic pregnant women when compared to the normal group (p=0.006, p=0.046) and area under ROC curve for MPV was found statistically significant. PC, MPV and PCT were found significantly increased in late-onset preeclampsia (p

WOS: 000308488205020 …

WOS: 000275367700008 Objective: To review of obstetric patients admitted to intensive care unit (ICU) in a tertiary care center and to assess the prevalence, causes and outcome of critically ill obstetric patients in ICU. Methods: In this retrospective study, obstetric ICU admissions in a University hospital over four-year period from January 20005 to April 2009 were analyzed. Results: The incidence of obstetric admissions to the ICU represented 1.6% of deliveries. All of the patients were admitted to the ICU postpartum. Pregnancy induced hypertension (64%) and obstetric hemorrhage (30%) were the two most common reasons for the ICU admission. The most common interventions were magnesium sulphate infusion (53.9%), mechanical ventilation (48%), and blood transfusion (52.9%). Maternal mortality rate was 8.8% with 44% of hemodynamic instability and multiple organ failure and with 44% of acute respiratory distress syndrome as the main causes of death. Conclusion: The most common cause of ICU admission were pregnancy induced hypertension and obstetric hemorrhage. Improved management strategies to these problems and increasing antenatal care may significantly decrease the maternal and fetal mortality rate in obstetric patients admitted to the ICU.

WOS: 000285461500011 Objective. The aim of this study was to investigate efficiency of flexible dose of recombinant FSH as an adjuvant to clomiphene citrate and to investigate factors that effect pregnancy rates in couples undergoing consecutive intrauterine insemination (IUI) cycles. Material and methods. Three hundred and seven couples who underwent 580 IUI cycles with ovarian stimulation by clomiphene citrate and/or gonadotropins were analyzed from November 2004 to September 2009, retrospectively. Results. The overall and the clinical pregnancy rates per cycle were 9.8% and 8.3% respectively. There was no pregnancy in 48 cycles which induced with recombinant FSH only as an adjuvant to clomiphene. The only statistically different parameter was the sperm motility between pregnant and non-pregnant groups, but discriminative analysis revealed that this sperm parameter could not be used in the prediction of pregnancy alone. Conclusion. Although combined use of clomiphene citrate and human menopausal gonadotropins are effective in IUI and ART cycles, to support mono follicular maturation furthermore, adjuvant low dose recombinant FSH does not seem to be helpful in IUI cycles alone.

WOS: 000273716800004 Objective. To evaluate the role of mid-trimester total human chorionic gonadotropin (hCG), alfa-fetoprotein (AFP) and unconjugated estriol (uE3) in the prediction of pre-eclampsia. Method. We carried out a retrospective analysis of hCG, AFP, uE3 levels taken between 16-18 weeks of gestation from 278 women. None of these women had abnormal karyotype fetuses or malformations. The levels of maternal serum hCG, AFP, uE3 were compared between 20 severe pre-eclampsia, 96 mild pre-eclampsia and 112 controls. Results. Levels of hCG in the second trimester triple test result from women who later developed severe pre-eclampsia were significantly elevated than control group (p=0.001, p

WOS: 000273717200006 Objective. The aim of this study was to investigate the influence of menstrual dysfunction in the form of oligomenorrhea and amenorrhea on bone mineral density (BMD) in women with polycystic ovary syndrome (PCOS). Study Design. Eighteen amenorrheic, 32 oligomenorrheic and 50 normally mensturating polycystic women participated in this study. Every woman underwent measurements of lumbar spine, femoral neck, wards, trochanter, shaft and total hip BMD by dual energy X-ray absorptiometry (DEXA). Results. The difference of mean serum total testosterone levels between groups were statically significant (p