7 results on '"Toshiyuki Tanimizu"'
Search Results
2. Dietary magnesium deficiency impairs hippocampus-dependent memories without changes in the spine density and morphology of hippocampal neurons in mice
- Author
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Mizuki Miyahara, Hirofumi Inoue, Satoru Oishi, Tatsurou Serita, Taikai Nagayoshi, Mariko Uehara, Toshiyuki Tanimizu, Shohei Takahashi, Satoshi Kida, and Ryuhei Tsuji
- Subjects
Male ,0301 basic medicine ,Dendritic Spines ,Conditioning, Classical ,Glutamic Acid ,Hippocampus ,Anxiety ,Hippocampal formation ,Biology ,Receptors, N-Methyl-D-Aspartate ,Synaptic Transmission ,Amygdala ,Mice ,03 medical and health sciences ,0302 clinical medicine ,Memory ,medicine ,Animals ,Learning ,Magnesium ,Neurons ,Neuronal Plasticity ,General Neuroscience ,Glutamate receptor ,Recognition, Psychology ,Fear ,Blockade ,Mice, Inbred C57BL ,030104 developmental biology ,medicine.anatomical_structure ,nervous system ,Dietary Supplements ,Synaptic plasticity ,Taste aversion ,Magnesium Deficiency ,Neuroscience ,030217 neurology & neurosurgery ,Social behavior - Abstract
Magnesium (Mg2+) is an essential mineral for maintaining biological functions. One major action of Mg2+ in the brain is modulating the voltage-dependent blockade of N-methyl-d-aspartate type glutamate receptors, thereby controlling their opening, which is crucial for synaptic plasticity. Therefore, Mg2+ has been shown to play critical roles in learning and memory, and synaptic plasticity. However, the effects of dietary Mg2+ deficiency (MgD) on learning and memory and the morphology of neurons contributing to memory performance have not been examined in depth. Here, we show that MgD impairs hippocampus-dependent memories in mice. Mice fed an MgD diet showed deficits in hippocampus-dependent contextual fear, spatial and social recognition memories, although they showed normal amygdala- and insular cortex-dependent conditioned taste aversion memory, locomotor activity, and emotional behaviors such as anxiety-related and social behaviors. However, MgD mice showed normal spine density and morphology of hippocampal neurons. These findings suggest that MgD impairs hippocampus-dependent memory without affecting the morphology of hippocampal neurons.
- Published
- 2019
3. Hippocampal clock regulates memory retrieval via Dopamine and PKA-induced GluA1 phosphorylation
- Author
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Toshiyuki Tanimizu, Rie Ishikawa, Tomohiro Rokukawa, Shintaro Okada, Shunsuke Hasegawa, Hotaka Fukushima, Miho Ohta, Sheena A. Josselyn, Tatsurou Serita, Hiroshi Hosoda, Satoshi Kida, Paul W. Frankland, Ryouka Kawahara-Miki, and Yue Zhang
- Subjects
Male ,0301 basic medicine ,endocrine system ,Science ,Dopamine ,Circadian clock ,General Physics and Astronomy ,Mice, Transgenic ,Hippocampal formation ,Biology ,Hippocampus ,Article ,Long-term memory ,General Biochemistry, Genetics and Molecular Biology ,Mice ,03 medical and health sciences ,0302 clinical medicine ,Downregulation and upregulation ,Circadian Clocks ,Cyclic AMP ,Zeitgeber ,medicine ,Animals ,Gene Knock-In Techniques ,Receptors, AMPA ,Phosphorylation ,lcsh:Science ,Maze Learning ,Multidisciplinary ,ARNTL Transcription Factors ,General Chemistry ,Cyclic AMP-Dependent Protein Kinases ,030104 developmental biology ,Dopamine receptor ,Mental Recall ,Models, Animal ,Forebrain ,lcsh:Q ,Female ,Neuroscience ,030217 neurology & neurosurgery ,medicine.drug - Abstract
Cognitive performance in people varies according to time-of-day, with memory retrieval declining in the late afternoon-early evening. However, functional roles of local brain circadian clocks in memory performance remains unclear. Here, we show that hippocampal clock controlled by the circadian-dependent transcription factor BMAL1 regulates time-of-day retrieval profile. Inducible transgenic dominant negative BMAL1 (dnBMAL1) expression in mouse forebrain or hippocampus disrupted retrieval of hippocampal memories at Zeitgeber Time 8–12, independently of retention delay, encoding time and Zeitgeber entrainment cue. This altered retrieval profile was associated with downregulation of hippocampal Dopamine-cAMP signaling in dnBMAL1 mice. These changes included decreases in Dopamine Receptors (D1-R and D5-R) and GluA1-S845 phosphorylation by PKA. Consistently, pharmacological activation of cAMP-signals or D1/5Rs rescued impaired retrieval in dnBMAL1 mice. Importantly, GluA1 S845A knock-in mice showed similar retrieval deficits with dnBMAL1 mice. Our findings suggest mechanisms underlying regulation of retrieval by hippocampal clock through D1/5R-cAMP-PKA-mediated GluA1 phosphorylation., The neural mechanisms that lead to a relative deficit in memory retrieval in the afternoon are unclear. Here, the authors show that the circadian - dependent transcription factor BMAL1 regulates retrieval through dopamine and glutamate receptor phosphorylation.
- Published
- 2019
4. Brain networks activated to form object recognition memory
- Author
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Kyohei Kono, Toshiyuki Tanimizu, and Satoshi Kida
- Subjects
0301 basic medicine ,Male ,Hippocampus ,Gene Expression ,Spatial memory ,03 medical and health sciences ,0302 clinical medicine ,Perirhinal cortex ,Neural Pathways ,medicine ,Animals ,Computer Simulation ,Prefrontal cortex ,Methods used to study memory ,Memory Consolidation ,Neurons ,Long-term memory ,musculoskeletal, neural, and ocular physiology ,General Neuroscience ,Brain ,Recognition, Psychology ,Immunohistochemistry ,Neuroanatomy of memory ,Mice, Inbred C57BL ,030104 developmental biology ,medicine.anatomical_structure ,nervous system ,Memory consolidation ,Psychology ,Neuroscience ,Proto-Oncogene Proteins c-fos ,030217 neurology & neurosurgery - Abstract
Object recognition memory allows discrimination of familiar and novel objects. Previous studies have shown the importance of several brain regions for object recognition memories; however, the mechanisms underlying the consolidation of object recognition (OR) memory at the anatomic level remain unknown. Here, we analyzed the brain network for the generation of OR memory in mice by measuring the expression of the immediate-early gene c-fos. We found that c-fos expression was induced in the hippocampus (CA1 and CA3 regions), insular cortex (IC), perirhinal cortex (PRh), and medial prefrontal cortex (mPFC) when OR memory was generated, suggesting that gene expression in these brain regions contributes to the formation of OR memory. Consistently, inhibition of protein synthesis in the mPFC blocked the formation of long-term OR memory. Importantly, network analyses suggested that the hippocampus, IC, PRh and mPFC show increased connectivity with other brain regions when OR memory is formed. Thus, we suggest that a brain network composed of the hippocampus, IC, PRh, and mPFC is required for the generation of OR memory by connecting with other brain regions.
- Published
- 2017
5. Functional Connectivity of Multiple Brain Regions Required for the Consolidation of Social Recognition Memory
- Author
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Kazune Kadoma, Paul W. Frankland, Satoshi Kida, Emiko Okano, Justin W. Kenney, and Toshiyuki Tanimizu
- Subjects
0301 basic medicine ,Male ,Brain activity and meditation ,Hippocampus ,Prefrontal Cortex ,Mice, Transgenic ,Amygdala ,Spatial memory ,03 medical and health sciences ,Mice ,0302 clinical medicine ,Memory ,medicine ,Animals ,Prefrontal cortex ,Social Behavior ,Anterior cingulate cortex ,Research Articles ,General Neuroscience ,Recognition, Psychology ,CREB-Binding Protein ,Mice, Inbred C57BL ,030104 developmental biology ,medicine.anatomical_structure ,nervous system ,Memory consolidation ,Nerve Net ,Consumer neuroscience ,Psychology ,Neuroscience ,030217 neurology & neurosurgery - Abstract
Social recognition memory is an essential and basic component of social behavior that is used to discriminate familiar and novel animals/humans. Previous studies have shown the importance of several brain regions for social recognition memories; however, the mechanisms underlying the consolidation of social recognition memory at the molecular and anatomic levels remain unknown. Here, we show a brain network necessary for the generation of social recognition memory in mice. A mouse genetic study showed that cAMP-responsive element-binding protein (CREB)-mediated transcription is required for the formation of social recognition memory. Importantly, significant inductions of the CREB target immediate-early genes c-fos and Arc were observed in the hippocampus (CA1 and CA3 regions), medial prefrontal cortex (mPFC), anterior cingulate cortex (ACC), and amygdala (basolateral region) when social recognition memory was generated. Pharmacological experiments using a microinfusion of the protein synthesis inhibitor anisomycin showed that protein synthesis in these brain regions is required for the consolidation of social recognition memory. These findings suggested that social recognition memory is consolidated through the activation of CREB-mediated gene expression in the hippocampus/mPFC/ACC/amygdala. Network analyses suggested that these four brain regions show functional connectivity with other brain regions and, more importantly, that the hippocampus functions as a hub to integrate brain networks and generate social recognition memory, whereas the ACC and amygdala are important for coordinating brain activity when social interaction is initiated by connecting with other brain regions. We have found that a brain network composed of the hippocampus/mPFC/ACC/amygdala is required for the consolidation of social recognition memory.SIGNIFICANCE STATEMENTHere, we identify brain networks composed of multiple brain regions for the consolidation of social recognition memory. We found that social recognition memory is consolidated through CREB-meditated gene expression in the hippocampus, medial prefrontal cortex, anterior cingulate cortex (ACC), and amygdala. Importantly, network analyses based on c-fos expression suggest that functional connectivity of these four brain regions with other brain regions is increased with time spent in social investigation toward the generation of brain networks to consolidate social recognition memory. Furthermore, our findings suggest that hippocampus functions as a hub to integrate brain networks and generate social recognition memory, whereas ACC and amygdala are important for coordinating brain activity when social interaction is initiated by connecting with other brain regions.
- Published
- 2016
6. Brain regions required for consolidation of social recognition memory
- Author
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Satoshi Kida, Yue Zhang, Hotaka Fukushima, Toshiyuki Tanimizu, and Kazune Kadoma
- Subjects
Consolidation (soil) ,General Neuroscience ,General Medicine ,Psychology ,Social recognition ,Cognitive psychology - Published
- 2011
7. Brain regions activated during consolidation of social recognition memory
- Author
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Satoshi Kida, Yue Zhang, Toshiyuki Tanimizu, Kazune Kadoma, and Hotaka Fukushima
- Subjects
Cognitive science ,Consolidation (soil) ,General Neuroscience ,General Medicine ,Psychology ,Social recognition - Published
- 2010
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