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164 results on '"Toshinai, Koji"'

1. Contributors

Author

Amano, Masafumi, primary, Ando, Hironori, additional, Andoh, Tadashi, additional, Baker, Michael E., additional, Cameron, Melissa S., additional, Daubnerová, Ivana, additional, Donald, John A., additional, Fukumura, Keisuke, additional, Funaba, Masayuki, additional, Haraguchi, Shogo, additional, Hayakawa, Yoichi, additional, Hirako, Satoshi, additional, Hyodo, Susumu, additional, Iguchi, Taisen, additional, Inui, Akio, additional, Kaiya, Hiroyuki, additional, Kakizawa, Sho, additional, Kamiyama, Takumi, additional, Kanamori, Yohei, additional, Kanda, Shinji, additional, Katayama, Hidekazu, additional, Kato, Takashi, additional, Katsu, Yoshinao, additional, Katsuura, Goro, additional, Kawada, Tsuyoshi, additional, Kimura, Atsushi P., additional, Kitamura, Keiichiro, additional, Kobayashi, Yuki, additional, Kodani, Yu, additional, Konno, Norifumi, additional, Kuraku, Shigehiro, additional, Minakata, Hiroyuki, additional, Mita, Masatoshi, additional, Miyagawa, Shinichi, additional, Miyazato, Mikiya, additional, Mizusawa, Kanta, additional, Mori, Kenji, additional, Morishita, Fumihiro, additional, Moriyama, Shunsuke, additional, Nagasaki, Hiroshi, additional, Nagata, Shinji, additional, Nakamachi, Tomoya, additional, Niwa, Ryusuke, additional, Ogino, Yukiko, additional, Ogoshi, Maho, additional, Ohira, Tsuyoshi, additional, Ohki-Hamazaki, Hiroko, additional, Ohtaki, Hirokazu, additional, Ohyama, Yoshihiko, additional, Oka, Yoshitaka, additional, Okamoto, Naoki, additional, Onizawa, Moe, additional, Osugi, Tomohiro, additional, Saito, Yumiko, additional, Sakai, Takafumi, additional, Sakamoto, Hirotaka, additional, Sakamoto, Tatsuya, additional, Sakata, Ichiro, additional, Satake, Honoo, additional, Sato, Seiichi, additional, Sato, Tomomi, additional, Seike, Hitomi, additional, Sekiguchi, Toshio, additional, Shimizu, Munetaka, additional, Shinki, Toshimasa, additional, Shinoda, Tetsuro, additional, Shiomi, Kunihiro, additional, Suzuki, Nobuo, additional, Tachibana, Tetsuya, additional, Takahashi, Akiyoshi, additional, Takahashi, Toshio, additional, Takaoka, Akinori, additional, Takei, Yoshio, additional, Takenoya, Fumiko, additional, Takeuchi, Sakae, additional, Tanaka, Yoshiaki, additional, Toshinai, Koji, additional, Tsukada, Takehiro, additional, Tsutsui, Kazuyoshi, additional, Tsutsui, Naoaki, additional, Ubuka, Takayoshi, additional, Ukena, Kazuyoshi, additional, Wada, Nobuhiro, additional, Watanabe, Jun, additional, Wong, Marty Kwok-Shing, additional, Yamada, Taisho, additional, Yamaguchi, Yoko, additional, Yamanaka, Naoki, additional, Yamauchi, Kiyoshi, additional, Yuge, Shinya, additional, Zhou, Yijun, additional, and Žitňan, Dušan, additional

Published
2021
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10. Neuroendocrine regulatory peptide-2 regulates feeding behavior via the orexin system in the hypothalamus

Author

Toshinai, Koji, Yamaguchi, Hideki, Kageyama, Haruaki, Matsuo, Takashi, Koshinaka, Keiichi, Sasaki, Kazuki, Shioda, Seiji, Minamino, Naoto, and Nakazato, Masamitsu

Subjects
Neuropeptides -- Properties, Food habits -- Physiological aspects, Hypothalamus -- Properties, Biological sciences
Abstract

Neuroendocrine regulatory peptide (NERP)-1 and NERP-2 are derived from distinct regions of VGF, a neurosecretory protein. [Vgf.sup.-/-] mice exhibit dwarfism and hypermetabolic rates, suggesting that VGF or VGF-derived peptides play important roles in energy metabolism. Here, we examined the role of NERPs in the central regulation of feeding and energy homeostasis. We attempted to identify NERPs expressing neurons in rats by immunohistochemistry. We studied the effects of intracerebroventricular (icy) administration of NERP-2 on feeding, body temperature, oxygen consumption, and locomotor activity in rats and mice. Intra-cerebroventricular administration of NERP-2, but not NERP-1 or a form of NERP-2 bearing a COOH-terminal glycine extension, increased food intake in rats. We investigated the downstream signal of NERP-2 on the basis of studies of NERP-2-induced feeding with neutralization of orexins, neuropeptide Y, or agouti-related protein. NERP-2 expression localized to the lateral hypothalamus (LH) and the dorsomedial perifornical hypothalamus in rats, colocalizing with orexins that activate feeding behavior and arousal. NERP-2 administration induced Fos protein, a marker of neuronal activation, in the orexin-immunoreactive neurons. Vgf mRNA levels were upregulated in the rat LH upon food deprivation. Intracerebroventricular administration of NERP-2 also increased body temperature, oxygen consumption, and locomotor activity in rats. Treatment with anti-NERP-2 IgG decreased food intake. NERP-2-induced bioactivities could be abrogated by administration of anti-orexins IgG or orexin receptor antagonists. NERP-2 did not induce food intake or locomotor activity in orexin-deficient mice. Our findings indicate that hypothalamic NERP-2 plays a role in the control of food intake and energy homeostasis via the orexin pathway. Thus, VGF serves as a precursor of multiple bioactive peptides exerting a diverse set of neuroendocrine functions. hypothalamic peptide; VGF protein; feeding regulation; energy homeostasis; neuronal activation doi: 10.1152/ajpendo.00768.2009.

Published
2010

13. Neuromedin U acts in the central nervous system to inhibit gastric acid secretion via CRH system

Author

Mondal, Muhtashan S., Date, Yukari, Murakami, Noboru, Toshinai, Koji, Shimbara, Takuya, Kangawa, Kenji, and Nakazato, Masamitsu

Subjects
Human physiology -- Research, Hypothalamus -- Physiological aspects, Peptides -- Physiological aspects, Gastric acid -- Physiological aspects, Corticotropin releasing hormone -- Physiological aspects, Biological sciences
Abstract

Neuromedin U (NMU) is a hypothalamic peptide involved in energy homeostasis and stress responses. NMU, when administered intracerebroventricularly, decreases food intake and body weight while increasing body temperature and heat production. In addition, NMU, acting via the corticotropin-releasing hormone (CRH) system, induces gross locomotor activity and stress responses. We studied the effect of intracerebroventricularly administered NMU (0.5-4 nmol) in the regulation of gastric functions in conscious rats. Intracerebroventricular administration of NMU significantly decreased gastric acid output to 30-60% and gastric emptying to 35-70% in a dose-dependent manner. Vagotomy did not abolish the inhibitory effect of NMU on pentagastrin-induced gastric acid secretion. Pretreatment with indomethacin (10 mg/kg), an inhibitor of prostaglandin synthesis, also did not affect NMU-induced acid inhibition. Pretreatment with anti-CRH IgG (1 [micro]g/rat), however, completely blocked NMU-induced acid inhibition (P < 0.01). Administration of yohimbine (4 mg/kg), an [[alpha].sub.2]-adrenergic receptor antagonist, also abolished NMU-induced acid inhibition (P < 0.01). These findings suggest that NMU is critical in the central regulation of gastric acid secretion via CRH. hypothalamic peptide; gastric emptying; corticotropin-releasing hormone; central administration

Published
2003

24. Ghrelin-Induced Food Intake Is Mediated via the Orexin Pathway

Author

Toshinai, Koji, Date, Yukari, Murakami, Noboru, Shimada, Mitsushi, Mondal, Muhtashan S., Shimbara, Takuya, Guan, Jian-Lian, Wang, Qing-Ping, Funahashi, Hisayuki, Sakurai, Takeshi, Shioda, Seiji, Matsukura, Shigeru, Kangawa, Kenji, and Nakazato, Masamitsu

Published
2003

28. Central Insulin Action Activates Kupffer Cells by Suppressing Hepatic Vagal Activation via the Nicotinic Alpha 7 Acetylcholine Receptor

Author

Kimura, Kumi, primary, Tanida, Mamoru, additional, Nagata, Naoto, additional, Inaba, Yuka, additional, Watanabe, Hitoshi, additional, Nagashimada, Mayumi, additional, Ota, Tsuguhito, additional, Asahara, Shun-ichiro, additional, Kido, Yoshiaki, additional, Matsumoto, Michihiro, additional, Toshinai, Koji, additional, Nakazato, Masamitsu, additional, Shibamoto, Toshishige, additional, Kaneko, Shuichi, additional, Kasuga, Masato, additional, and Inoue, Hiroshi, additional

Published
2016
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37. Neuroendocrine regulatory peptide-2 stimulates glucose-induced insulin secretion in vivo and in vitro

Author

Moin, Abu Saleh Md., primary, Yamaguchi, Hideki, additional, Rhee, Marie, additional, Kim, Ji-Wom, additional, Toshinai, Koji, additional, Waise, T.M. Zaved, additional, Naznin, Farhana, additional, Matsuo, Takashi, additional, Sasaki, Kazuki, additional, Minamino, Naoto, additional, Yoon, Kun-Ho, additional, and Nakazato, Masamitsu, additional

Published
2012
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49. Peptidomic Identification and Biological Validation of Neuroendocrine Regulatory Peptide-1 and -2

Author

Yamaguchi, Hideki, primary, Sasaki, Kazuki, additional, Satomi, Yoshinori, additional, Shimbara, Takuya, additional, Kageyama, Haruaki, additional, Mondal, Muhtashan S., additional, Toshinai, Koji, additional, Date, Yukari, additional, González, Luis J., additional, Shioda, Seiji, additional, Takao, Toshifumi, additional, Nakazato, Masamitsu, additional, and Minamino, Naoto, additional

Published
2007
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