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We introduce a concept of laser-generated neutrons to transmute transuranic elements separated from spent nuclear fuel (SNF) and dissolved in a molten salt to form a subcritical core whose liquid s...

The important role of magnetic fields in the phenomena in and evolution of the Universe is well appreciated. A salient example of this is to make (often episodic) large magnetic fields in AGN accretion disks and their emanation of well-collimated and longitudinally extended astrophysical jets. Such typical cases or related astrophysical processes, we find, provide a fertile ground for exciting large-amplitude oscillations in the magnetic fields that constitute the spine of the jets. The energy sources of these oscillations can be traced originally to the gravitational energy of the central object. During their long propagation along the jet, because of the gradual changes of the density and magnetic fields, these large magnetic pulsations turn into relativistic amplitude electromagnetic (EM) pulses, which in turn induce intense wakefields that are capable of acceleration of electrons, positrons, and ions to high energies. In this review, we survey a variety of astrophysical objects ranging from as large as the cosmic AGN accretion disks and their jets to as small as microquasars, to find or predict that there exist common astrophysical processes of emission of high-energy particles and gamma (and other EM) emissions. A variety of these objects will be ideally observed and studied in the multimessenger astrophysical observations. One example that already stuck out was the case of the simultaneous observations of gravitational wave emission and gamma-ray pulse from the collision of the two neutron stars and their subsequent structure formation (such as a disk) around them.

We have investigated electro-magnetic (EM) wave pulses in a jet from a neutrino driven accretion flow (NDAF) around a black hole (BH). NDAFs are massive accretion disks whose accretion rates of $\dot{M}\approx 0.01 - 10 \mathrm{M}_\odot/\mathrm{s}$ for stellar-mass BHs. Such an extreme accretion may produce a collimated relativistic outflow like a magnetically driven jet in active galactic nuclei and micro-quasars. When we consider strong toroidal magnetic field stranded in the inner-region of a NDAF disk and magnetic impulses on the jet, we find that they lead to the emanation of high energy emissions for gamma-ray bursts as well as high energy cosmic rays. When Alfv\'enic wave pulses are generated by episodic immense accretions, it propagates along the large-scale structured magnetic field in the jet. Once the Alfv\'enic wave pulses reach at nearly the speed of light in the underdense condition, it turns into EM wave pulses which produce plasma wakes behind them. These wakefields exert a collective accelerating force synchronous to the motion of particles. As a result, the wakefield acceleration premises various observational signatures, such as pulsating bursts of high energy gamma-rays from accelerated electrons, pulses of neutrinos from accelerated protons, and protons with maximum energies beyond $10^{20}~\mathrm{eV}$., Comment: 26 pages, 6 figures, accepted to ApJ

In TAE Technologies’ current experimental device, C-2W, neutral beam injection creates a large fast ion population that sustains a field-reversed configuration (FRC) plasma. Diagnosis of these fast ions is therefore critical for understanding the behavior of the FRC. Neutral Particle Analyzers (NPAs) are used to measure the energy spectrum of fast ions that charge exchange on background or beam neutrals and are lost from the plasma. To ensure correct diagnosis of the fast ion population, a calibration check of the NPAs was performed. A novel, generally applicable method for an in situ relative calibration of diagnostics on an unknown source with a small dataset was developed. The method utilizes a machine learning technique, Generalized Additive Models (GAMs), to reconstruct the diagnostic source distribution, and Stochastic Gradient Descent (SGD) to determine the NPA channel calibration factors. The results on both synthetic and experimental datasets are presented.

The electron dynamics of laser wakefield acceleration (LWFA) is examined in the high-density regime using particle-in-cell simulations. These simulations model the electron source as a target of carbon nanotubes. Carbon nanotubes readily allow access to near-critical densities and may have other advantageous properties for potential medical applications of electron acceleration. In the near-critical density regime, electrons are accelerated by the ponderomotive force followed by the electron sheath formation, resulting in a flow of bulk electrons. This behavior represents a qualitatively distinct regime from that of low-density LWFA. A quantitative entropy index for differentiating these regimes is proposed. The dependence of accelerated electron energy on laser amplitude is also examined. For the majority of this study, the laser propagates along the axis of the target of carbon nanotubes in a 1D geometry. After the fundamental high-density physics is established, an alternative, 2D scheme of laser acceleration of electrons using carbon nanotubes is considered.

With the advent of the Thin Film Compression, high energy single-cycled laser pulses have become an eminent path to the future of new high-field science. An existing CPA high power laser pulse such as a commercially available PW laser may be readily converted into a single-cycled laser pulse in the 10PW regime without losing much energy through the compression. We examine some of the scientific applications of this, such as laser ion accelerator called single-cycle laser acceleration (SCLA) and bow wake electron acceleration. Further, such a single-cycled laser pulse may be readily converted through relativistic compression into a single-cycled, X-ray laser pulse. We see that this is the quickest and very innovative way to ascend to the EW (exawatt) and zs (zeptosecond) science and technology. We suggest that such X-ray laser pulses have a broad and new horizon of applications. We have begun exploring the X-ray crystal (or nanostructured) wakefield accelerator and its broad and new applications into gamma rays. Here, we make a brief sketch of our survey of this vista of the new developments.

This research explores the performance of graphene as a coating for plasma-facing components (PFCs) in a nuclear fusion environment. Our recent studies have shown that graphene can act as a...

Our basic observations from daily experiences as well as sophisticated experiments suggest causality in various branches of physics (and beyond). Causality is mathematically reflected in the analyticity of the system's response function, which relates the dispersion of the system to the dissipation. We also observe that the dissipation is related to fluctuations in that system. By surveying introductory elements (and thus mostly undergraduate textbooks) of this relation, the student finds the interrelationship among different sub-disciplines of physics otherwise buried. A pedagogical experiment in class reveals a student's enjoyment in learning through this experience.Our basic observations from daily experiences as well as sophisticated experiments suggest causality in various branches of physics (and beyond). Causality is mathematically reflected in the analyticity of the system's response function, which relates the dispersion of the system to the dissipation. We also observe that the dissipation is related to fluctuations in that system. By surveying introductory elements (and thus mostly undergraduate textbooks) of this relation, the student finds the interrelationship among different sub-disciplines of physics otherwise buried. A pedagogical experiment in class reveals a student's enjoyment in learning through this experience.

Efficiently heating a magnetically confined plasma to thermonuclear temperatures remains a central issue in fusion energy research. One well-established technique is to inject beams of neutral particles into the plasma, a process known as neutral beam injection. In the classical picture, fast ions generated from neutral beam injection predominantly heat electrons as they are slowed by friction. This electron heat is then collisionally coupled to the plasma ions, which comprise the fusion fuel. Fast ions can also drive plasma waves, which divert energy from the fuel and can degrade confinement. Here we present new observations from a field reversed configuration plasma in which a beam-driven wave in the open field line region couples directly to fuel ions, drawing a high-energy tail on subcollisional timescales that dramatically enhances the fusion rate. This mode therefore allows the beam energy to bypass the electron channel and does so without having a deleterious effect on global plasma confinement. Our results demonstrate a means of directly and non-destructively coupling energy from fast ions to plasma ions, which may pave the way for improved neutral beam injection heating efficiency or the prevention of ash accumulation with alpha channelling. A major challenge for achieving useful thermonuclear fusion regimes is heating plasma to reactive temperature conditions. It is demonstrated experimentally how energetic ions, generated via neutral beam injection, can be exploited for this process.

To simulate an early 20th century viral pneumonia radiotherapy treatment using modern fluoroscopy and evaluated it according to current dose guidelines. Monte Carlo was used to assess the dose distribution on an anthropomorphic phantom. Critical organs were: skin, breasts, esophagus, ribs, vertebrae, heart, thymus, and spinal cord. A 100 kVp beam with 3 mm Al HVL, 25 × 25 cm2 posterior-anterior (PA) field and 50 cm source-to-surface distance were simulated. Simulations had a resolution of 0.4 × 0.4 × 0.06 cm3 and a 6% uncertainty. Hundred percent dose was normalized to the skin surface and results were displayed in axial, coronal, and sagittal planes. Dose volume histograms were generated in MATLAB for further analysis. Prescription doses of 0.3, 0.5, and 1.0 Gy were applied to the 15% isodose for organ-dose comparison to current tolerances and potential risk of detriment. Ninety-five and ninety-seven percent of the right and left lung volumes, respectively, were well-covered by the 15% isodose line. For the 0.3, 0.5, and 1.0 Gy prescriptions, the maximum skin doses were 2.9, 4.8, and 9.6 Gy compared to a 2.0 Gy transient erythema dose threshold; left/right lung maximum doses were 1.44/1.46, 2.4/2.4, and 4.8/4.9 Gy compared to a 6.5 Gy pneumonitis and 30 Gy fibrosis thresholds; maximum heart doses were 0.5, 0.9, and 1.8 Gy compared to the 0.5 Gy ICRP-recommendation; maximum spinal cord doses were 1.4, 2.3, and 4.6 Gy compared to 7.0 Gy single fraction dose threshold. Maximum doses to other critical organs were below modern dose thresholds. A 100 kVp PA field could deliver a 0.3 Gy or 0.5 Gy dose without risk of complications. However, a 1.0 Gy dose treatment could be problematic. Critical organ doses could be further reduced if more than one treatment field is used.

Intense few-cycle laser pulses have a breadth of applications in high energy density science, including particle acceleration and x-ray generation. Multi-amplifier laser system pulses have durations of tens of femtoseconds or longer. To achieve high intensities at the single-cycle limit, a robust and efficient post-compression scheme is required. We demonstrate a staged compression technique using self-phase modulation in thin dielectric media, in which few-cycle pulses can be produced. The few-cycle pulse is then used to generate extreme ultravoilet light via high harmonic generation at strong field intensities and to generate MeV electron beams via laser solid interactions at relativistic intensities.

X-ray irradiation of high Z elements causes photoelectric effects that include the release of Auger electrons that can induce localized DNA breaks. We have previously established a tumor spheroid-based assay that used gadolinium containing mesoporous silica nanoparticles and synchrotron-generated monochromatic X-rays. In this work, we focused on iodine and synthesized iodine-containing porous organosilica (IPO) nanoparticles. IPO were loaded onto tumor spheroids and the spheroids were irradiated with 33.2 keV monochromatic X-ray. After incubation in CO₂ incubator, destruction of tumor spheroids was observed which was accompanied by apoptosis induction, as determined by the TUNEL assay. By employing the γH2AX assay, we detected double strand DNA cleavages immediately after the irradiation. These results suggest that IPO first generate double strand DNA breaks upon X-ray irradiation followed by apoptosis induction of cancer cells. Use of three different monochromatic X-rays having energy levels of 33.0, 33.2 and 33.4 keV as well as X-rays with 0.1 keV energy intervals showed that the optimum effect of all three events (spheroid destruction, apoptosis induction and generation of double strand DNA breaks) occurred with a 33.2 keV monochromatic X-ray. These results uncover the preferential effect of K-edge energy X-ray for tumor spheroid destruction mediated by iodine containing nanoparticles., アインシュタインの光電効果をがん細胞の中で再現 放射線治療への新展開. 京都大学プレスリリース. 2021-07-14., Quantum physics helps destroy cancer cells. 京都大学プレスリリース. 2021-07-14.

International audience; In order to implement radiotherapy based on a laser accelerator, it is necessary to precisely control the spatial distribution and energy spectrum of the proton beams to meet the requirements of the radiation dose distribution in the three-dimensional biological target. A compact laser plasma accelerator has been built at Peking University, which can reliably generate and transport MeV-energy protons with a specified energy onto the irradiation platform. In this paper, we discuss several technologies for the accurate control of a laser-accelerated proton beam with large divergence angle and broad energy spread, including the determination of the beam source position with micron accuracy, a tuning algorithm for the transport line which we refer to as “matching-image-point two-dimensional energy analysis” to realize accurate energy selection, and the control of beam distribution uniformity. In the prototype experiment with low energy protons and 0.5-Hz irradiation rate, a tailored energy deposition is demonstrated, which shows the potential feasibility of future irradiation based on laser-accelerated proton beams.

We consider that electromagnetic pulses produced in the jets of this innermost part of the accretion disk accelerate charged particles (protons, ions, electrons) to very high energies via wakefield acceleration, including energies above 10[Formula: see text] eV for the case of protons and nucleus and 10[Formula: see text] eV for electrons by electromagnetic wave-particle interaction. Thereby, the wakefield acceleration mechanism supplements the pervasive Fermi’s stochastic acceleration mechanism (and overcomes its difficulties in the highest energy cosmic ray generation). The episodic eruptive accretion in the disk by the magneto-rotational instability gives rise to the strong Alfvenic pulses, which acts as the driver of the collective accelerating pondermotive force. This pondermotive force drives the wakes. The accelerated hadrons (protons and nuclei) are released to the intergalactic space to be ultra-high energy cosmic rays. The high-energy electrons, on the other hand, emit photons to produce various non-thermal emissions (radio, IR, visible, UV, and gamma-rays) of active galactic nuclei in an episodic manner, giving observational telltale signatures.

The collective interaction between intense ion beams and plasmas is studied by simulations and experiments, where an intense proton beam produced by a short pulse laser is injected into a pre-ionized gas. It is found that, depending on its current density, collective effects can significantly alter the propagated ion beam and the stopping power. The quantitative agreement that is found between theories and experiments constitutes the first validation of the collective interaction theory. The effects in the interaction between intense ion beams and background gas plasmas are of importance for the design of laser fusion reactors as well as for beam physics. Keywords: Two stream instabilities, Ultra intense short pulse laser, Proton beam, Wake field, Electron plasma wave, Laser plasma interaction, PACS codes: 52.38.Kd, 29.27.Fh, 52.40.Kh, 52.70.Nc

The advanced beam-driven FRC is a Field Reversed Configuration (FRC) with the addition of neutral beam (NB) injection, electrode biasing, and magnetic expander divertors. The resulting configuration has novel features that make it necessary to revisit many key results in FRC theory. Three of these features include (i) a large energetic ion population, (ii) in-principle capability to adjust the electric field and rotation profiles, and (iii) a combination of magnetic and electrostatic confinement of electrons in the SOL. In some fueling scenarios the electron density profile may exhibit a significant peak outside of the separatrix. To explore these features a hybrid fluid/kinetic equilibrium model has been used to reconstruct typical experimental profiles of the C-2W experiment. Results indicate that the energetic ions provide at least 50% of the total plasma pressure. These equilibrium profiles have been used as initial conditions for global, cross-separatrix, turbulent transport simulations using the 3D electrostatic particle-in-cell code ANC. Electrostatic fluctuations were found to nonlinearly saturate at an amplitude which is an order magnitude lower than that observed previously. The tokamak turbulence code GTC code has also been extended to handle FRC physics in the new GTC-X version, which has been used to perform simulations of turbulent transport in the SOL relevant to electrode biasing. It is found that equilibrium × flow shear significantly decreases ion temperature gradient saturation amplitude and ion heat transport. Also in the SOL, a 1D2V continuum code has been developed and applied to parallel electron heat transport. Results show the formation of pre-sheath potential and reduction of parallel electron heat loss close to the ideal ambipolar limit, a result which has been validated by experimental diagnostics. These transport modifications caused by the three novel configuration features help to explain the remarkable plasma performance of the C-2W experiment.

Self-organized field-reversed configuration (FRC)-like formation was observed after the super-sonic/Alfvénic collisional merging of two FRCs in the FAT-CM device at Nihon University. In this experiment, two FRCs were generated initially in two separate field-reversed theta-pinch type formation regions. Those two formation regions are coaxially connected to opposite ends of a cylindrical confinement chamber. The formed FRCs are oppositely-translated and collide in the middle of the confinement chamber at super-sonic/Alfvénic velocity. During the collision, the merged plasmoid experiences destructive disturbance and loses its fast toroidal flow and characteristic FRC property of having a field-reversed magnetic configuration to become a magnetized plasma without ordered structure. After this dynamic collision, a magnetic configuration of FRC with fast toroidal rotation is self-organized within a few tens of microseconds. This observation indicates robustness of the extremely high-beta, simple magnetic configuration.

高Z元素にX線を照射すると、局所的なDNA切断を誘発する可能性のあるオージェ電子の放出を含む光電効果を引き起こす。我々はこれまで、ガドリニウムを含有したメソポーラスシリカナノ粒子と放射光単色X線によるがんスフェロイドの殺傷効果について研究を進めてきた。本報ではヨウ素に焦点を当て、ヨウ素を含有した多孔質有機シリカ（IPO）ナノ粒子を合成した。IPOをがんスフェロイドに取り込ませ、スフェロイドに33.2keVの単色X線を照射した。インキュベーション後、TUNEL assay法で評価をしたところ、アポトーシス誘導を伴うがんスフェロイドの破壊が観察された。さらに、γH2AX assay法によって、照射直後にDNAの二重鎖切断が起きていることを確認した。これらの結果は、IPO がX線照射時にまずDNAの二重鎖切断を引き起こし、続いて、がん細胞をアポトーシスに誘導することを示唆している。33.0～33.4keVの単色X線で、エネルギーを0.1keVずつ変化させながら実験を行ったところ、がんの形状破壊、アポトーシス誘導、DNA二重鎖切断の3つのイベントは、すべて33.2keVの単色X線のときに発生していた。これらの結果は、ヨウ素含有ナノ粒子によって媒介されたがんスフェロイド破壊における、K吸収端エネルギーX線の優先的効果を示している。

Electroreductive hydrogenation of activated olefins was investigated using the concept of site isolation. It was shown by electrochemical measurements as well as preparative electrolyses that the use of silica gel-supported sulfonic acid (Si-SO3H) promotes the protonation step in electroreductive hydrogenation of activated olefins without electroreductive destruction at the cathode. On the basis of the concept of site isolation, electroreductive hydrogenation of several activated olefins was successfully carried out to provide the corresponding hydrogenation products in high yields. Keywords: Site isolation, Electroreductive hydrogenation, Activated olefin, Solid-supported acid, Cation exchange

Synchrotron generated monochromatic X-rays can be precisely tuned to the K-shell energy of high Z materials resulting in the release of the Auger electrons. In this work, we have employed this mechanism to destruct tumor spheroids. We first loaded gadolinium onto the surface of mesoporous silica nanoparticles (MSNs) producing gadolinium-loaded MSN (Gd-MSN). When Gd-MSN was added to the tumor spheroids, we observed efficient uptake and uniform distribution of Gd-MSN. Gd-MSN also can be taken up into cancer cells and localize to a site just outside of the cell nucleus. Exposure of the Gd-MSN containing tumor spheroids to monochromatic X-ray beams resulted in almost complete destruction. Importantly, this effect was observed at an energy level of 50.25 keV, but not with 50.0 keV. These results suggest that it is possible to use precisely tuned monochromatic X-rays to destruct tumor mass loaded with high Z materials, while sparing other cells. Our experiments point to the importance of nanoparticles to facilitate loading of gadolinium to tumor spheroids and to localize at a site close to the nucleus. Because the nanoparticles can target to tumor, our study opens up the possibility of developing a new type of radiation therapy for cancer., 単色Ｘ線とナノ粒子により、がん患部でX線エネルギー効果を増幅する方法の開発に成功 --オージェ電子発見から100年、放射線がん治療の新境地を開く--. 京都大学プレスリリース. 2019-10-02.

International audience; An ultrafast intense laser pulse drives coherent wakefields of relativistic amplitude with a high phase velocity robustly supported by the plasma. The structures of wakes and sheaths in plasma are contrasted. While the large amplitude of wakefields involves collective resonant oscillations of the eigenmode of the entire population of plasma electrons, the wake phase velocity ~c and ultrafast nature of the laser pulse introduce the wake stability and rigidity. When the phase velocity decreases, wakefields turn into sheaths, which are more suitable for ion acceleration. This short review reports on 4 decades of discoveries on laser plasma accelerators.

A compact laser plasma accelerator (CLAPA) that can stably produce and transport proton ions with different energies less than 10 MeV, $l1%$ energy spread, several to tens of pC charge, is demonstrated. The high current proton beam with continuous energy spectrum and a large divergence angle is generated by using a high contrast laser and micron thickness targets, which later is collected, analyzed and refocused by an image-relaying beam line using a combination of quadrupole and bending electromagnets. It eliminates the inherent defects of the laser-driven beams, realizes precise manipulation of the proton beams with reliability, availability, maintainability and inspectability (RAMI), and takes the first step towards applications of this new generation of accelerator. With the development of high-rep rate Petawatt (PW) laser technology, we can now envision a new generation of accelerator for many applications in the near future soon.

International audience; Recent developments in fiber lasers and nanomaterials have allowed the possibility of using laser wakefield acceleration (LWFA) as the source of low-energy electron radiation for endoscopic and intraoperative brachytherapy, a technique in which sources of radiation for cancer treatment are brought directly to the affected tissues, avoiding collateral damage to intervening tissues. To this end, the electron dynamics of LWFA is examined in the high-density regime. In the near-critical density regime, electrons are accelerated by the ponderomotive force followed by an electron sheath formation, resulting in a flow of bulk electrons. These low-energy electrons penetrate tissue to depths typically less than 1 mm. First a typical resonant laser pulse is used, followed by lower-intensity, longer-pulse schemes, which are more amenable to a fiber-laser application.

International audience; Thin film compression to the single-cycle regime combined with relativistic compression offers a method to transform conventional ultrafast laser pulses into attosecond X-ray laser pulses. These attosecond X-ray laser pulses are required to drive wakefields in solid density materials which can provide acceleration gradients of up to TeV/cm. Here we demonstrate a nearly 99% energy efficient compression of a 6.63 mJ, 39 fs laser pulse with a Gaussian mode to 20 fs in a single stage. Further, it is shown that as a result of Kerr-lensing, the focal spot of the system is slightly shifted on-axis and can be recovered by translating the imaging system to the new focal plane. This implies that with the help of wave-front shaping optics the focusability of laser pulses compressed in this way can be partially preserved.

TeV center-of-mass energy electron-positron linear colliders comprising seamlessly staged capillary laser-plasma accelerators are presented. A moderate intensity laser pulse coupled with the single electromagnetic hybrid mode in a gas-filled capillary can generate plasma waves in the linear regime, where laser wakefields can accelerate equally focused electron and positron beams. In multiple stage capillary accelerators, a particle beam with respect to the laser wakefield can undergo consecutive acceleration up to TeV energies, associated with continuous transverse focusing in a beam size down to a nanometer level, being capable of a promising electron-positron linear collider with very high luminosities of the order of 10[Formula: see text] cm[Formula: see text]s[Formula: see text]. The transverse and longitudinal beam dynamics of beam particles in plasma wakefields with the effects of radiation reaction and multiple Coulomb scattering are investigated numerically to estimate the luminosities in beam-beam collisions with the effects of beamstrahlung radiation and bunch disruption.