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3. A real-life study of daratumumab-bortezomib-dexamethasone (D-VD) in lenalidomide exposed/refractory multiple myeloma patients: a report from the Triveneto Myeloma Working Group

Author

Barilà, Gregorio, Quaglia, Francesca Maria, Furlan, Anna, Pescosta, Norbert, Bonalumi, Angela, Marcon, Chiara, Pascarella, Anna, Tinelli, Martina, De March, Elena, Lico, Albana, Sartori, Roberto, Clissa, Cristina, De Sabbata, Giovanni, Nappi, Davide, Porrazzo, Marika, De Marchi, Roberta, Pavan, Laura, Tosetto, Alberto, Gherlinzoni, Filippo, Krampera, Mauro, Bassan, Renato, Patriarca, Francesca, Semenzato, Gianpietro, and Zambello, Renato

Published
2024
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4. Dazzling damselfish: investigating motion dazzle as a defence strategy in humbug damselfish (Dascyllus aruanus)

Author

Louise Tosetto, Nathan S. Hart, and Laura A. Ryan

Subjects
Camouflage, Animal colouration, Antipredator strategy, Behaviour, Vision, Medicine, Biology (General), QH301-705.5
Abstract

Many animals possess high-contrast body patterns. When moving, these patterns may create confusing or conflicting visual cues that affect a predator’s ability to visually target or capture them, a phenomenon called motion dazzle. The dazzle patterns may generate different forms of optical illusion that can mislead observers about the shape, speed, trajectory and range of the animal. Moreover, it is possible that the disruptive visual effects of the high contrast body patterns can be enhanced when moving against a high contrast background. In this study, we used the humbug damselfish (Dascyllus aruanus) to model the apparent motion cues of its high contrast body stripes against high contrast background gratings of different widths and orientations, from the perspective of a predator. We found with higher frequency gratings, when the background is indiscriminable to a viewer, that the humbugs may rely on the confusing motion cues created by internal stripes. With lower frequency gratings, where the background is likely perceivable by a viewer, the humbugs can rely more on confusing motion cues induced by disruption of edges from both the background and body patterning. We also assessed whether humbugs altered their behaviour in response to different backgrounds. Humbugs remained closer and moved less overall in response to backgrounds with a spatial structure similar to their own striped body pattern, possibly to stay camouflaged against the background and thus avoid revealing themselves to potential predators. At backgrounds with higher frequency gratings, humbugs moved more which may represent a greater reliance on the internal contrast of the fish’s striped body pattern to generate motion dazzle. It is possible that the humbug stripes provide multiple protective strategies depending on the context and that the fish may alter their behaviour depending on the background to maximise their protection.

Published
2024
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5. Real-World Efficacy and Safety of Plasma-Derived Von Willebrand Factor-Containing Factor VIII Concentrates in Patients With Von Willebrand Disease in Italy

Author

Augusto B. Federici MD, Rita Carlotta Santoro MD, Cristina Santoro MD, Lisa Pieri MD, Roberto Mario Santi MD, Giovanni Barillari MD, Alessandra Borchiellini MD, Alberto Tosetto MD, Ezio Zanon MD, Raimondo De Cristofaro MD, Esther Mairal MD, and Roser Mir PhD

Subjects
Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Plasma-derived von Willebrand factor-containing factor VIII concentrates (pd-VWF/FVIII-C) are the mainstay of treatment in von Willebrand disease (VWD). Real-world data on efficacy and safety of these pd-VWF/FVIII-C are required. To retrospectively evaluate the efficacy and safety of pd-VWF/FVIII-C (Fanhdi® and Alphanate®, Grifols) in clinical practice in Italy. A multicentric, observational, retrospective study at 10 Italian centers was conducted. Eligible patients diagnosed with inherited VWD (ISTH criteria) were treated with either Fanhdi® or Alphanate® for bleeding episodes, prevention of surgical bleeding and secondary long-term prophylaxis (SLTP) according to clinical practice with medical records collected from January 2007 to December 2019. Efficacy/safety of pd-VWF/FVIII-C was assessed according to FDA-agreed objective criteria following regulatory procedures. Fifty-seven patients (M/F: 21/36) were enrolled in the study with the following VWD types: VWD1 (n = 29, 52%), VWD2A (n = 10, 18%), VWD2B (n = 7, 12%), VWD2M (n = 2, 4%), VWD2N (n = 1, 2%), VWD2 unclassified (n = 1, 2%), and VWD3 (n = 7, 12%). These pd-VWF/FVIII-C were used to manage 58 bleeding episodes (n = 24 patients), 100 surgeries (n = 47 patients), and 7 SLTP (n = 6 patients). Global clinical efficacy with these pd-VWF/FVIII-C was reported to be excellent/good in 85% of bleeding episodes, 98% of surgeries, and 100% of SLTP. As far as safety, no adverse-drug-related episodes, immunogenic or thrombotic events were reported. This study confirmed that Fanhdi® and Alphanate® were effective and safe in the management of bleeding episodes, the prevention of bleeding during surgeries and for SLTP in Italian patients with inherited VWD.

Published
2024
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10. More early bleeds associated with high baseline direct oral anticoagulant levels in atrial fibrillation: the MAS study

Author

Testa, Sophie, Dellanoce, Claudia, Paoletti, Oriana, Morandini, Rossella, Tala, Maurizio, Ciampa, Antonio, Gaeta, Martina, Chiarugi, Paolo, Casini, Monica, Guerri, Valentina, Santoro, Rita Carlotta, Iannaccaro, Piergiorgio, Iannone, Angela Maria, Campagna, Maddalena, De Candia, Erica, Alberelli, Maria Adele, Basso, Maria, De Cristofaro, Raimondo, Di Gennaro, Leonardo, Ferretti, Antonietta, Sorrentino, Silvia, Pignatelli, Pasquale, Menichelli, Danilo, Pastori, Daniele, Saliola, Mirella, Faioni, Elena Maria, Avarello, Ilaria, Razzari, Cristina, Chistolini, Antonio, Aprile, Simona Michela, Santoro, Cristina, Serrao, Alessandra, Esteban, Maria del Pilar, Ricca, Sergio, Marietta, Marco, Arletti, Laura, Coluccio, Valeria, Debbia, Giulia, Grisolia, Deborah, Serra, Domizio, Orselli, Alberto, Pescarollo, Alessandra, Verna, Sandra, Di Gregorio, Patrizia, Cassetti, Giuseppina, Molteni, Mauro, Monelli, Mauro, Paparo, Carmelo, Resani, Guido, Di Gregorio, Nicoletta, Grassi, Davide, Lodigiani, Corrado, Banfi, Elena, Ferrazzi, Paola, Librè, Luca, Pacetti, Veronica, Sacco, Clara, Bucciarelli, Paolo, Martinelli, Ida, Abbattista, Maria, Artoni, Andrea, Capecchi, Marco, Gianniello, Francesca, Scimeca, Barbara, Turrini, Anna, Moretta, Francesca, Parise, Giorgio, Zeccardo, Ciro, Fregoni, Vittorio, Balboni, Massimo, Leggio, Federico, Poli, Daniela, Ria, Luigi, Spagnolo, Marina, Dirienzo, Giovanni, Dirienzo, Lavinia, Fuzio, Diana, Donadini, Marco Paolo, Squizzato, Alessandro, Ageno, Walter, Colombo, Giovanna, Galliazzo, Silvia, Gallo, Andrea, Tamborini Permunian, Eleonora, Virano, Alexandra, Falanga, Anna, Barcella, Luca, Gamba, Sara, Lerede, Teresa, Maggioni, Anna, Russo, Laura, Schieppati, Francesca, Zunino, Federica, Barillari, Giovanni, Bertone, Antonella, Poz, Alessandra, Venturelli, Ugo, Serricchio, Giuseppina, Brevi, Francesca, Palareti, Gualtiero, Legnani, Cristina, Cini, Michela, Antonucci, Emilia, Tripodi, Armando, and Tosetto, Alberto

Published
2024
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11. The experience of pregnant women and their families who were infected with covid-19 before vaccination: A qualitative approach within a multicenter study in Brazil

Author

Metelus, Sherly, Castro, Lester, Pabon, Stephanie, Silva, Amanda D, Junior, Paulo S R, Sardinha, Thais G, Japenga, Rodolfo R, Urquiza, Erica R F, Machado, Maíra R, Simões, Marcela Maria, Solda, Larissa M, Yazaki-Sun, Sue, Mota, Priscilla, Soares, Arimaza C, Machado, Ellen, Bergmann, Anne, Raupp dos Santos, Gustavo, Peres, Patrícia B, Arbeli, Cristiane L, Quevedo, Rafael M, Yamashita, Carolina F, Corradin, Julia D, Bergamini, Isabella, Ramos, José Geraldo L, Oppermann, Maria Lúcia R, Quadro, Laisa S, Marins, Lina, Paniz, Érika V, Xavier, Thaís Vicentini, Parreira, Bruna E, Tosetto, Aline, Savazoni, Sabrina, Costa, Aline C, Almeida, Marina HL, Moura, Bruna FV, França, Lidiane R, Vieira, Hanna, Aquino, Rafael B, Leite, Débora F, Monteiro, Isabella, Nakamura-Pereira, Marcos, Guerra, Bruna O, Gorga, Gabriela, Pinheiro, Daisy, Cordeiro, Denise, Miná, Priscila L, Dornellas, Carol, Oliveira, Kevin FA, Makyama, Mariana Emi Varicoda, Leal, Caio, Amana, Rayra, Santos, Cristiane O, dos Santos, Marina M, Neto, Carlos, Gomes, Thiago, Pereira, Isabela R, Salustrino, Clélia Andrade, Pontes, Valéria B, Franco, Roberto Allen da Silva, Bilibio, João Paolo, Brito, Gislânia P F, Pinto, Hana Paula C, de Oliveira, Danielle Leal, Guerra, Andrezza A, Moura, Andrea O, Pantoja, Natasha, David, Fernanda, Silva, Alina, Bacha, Angela M, Borovac-Pinheiro, Anderson, Pereira, Belmiro G, Amaral, Eliana M, Ferreira, Elton, Milanez, Helaine MBPM, Caldas, Jamil P S, Baccaro, Luiz F, Nomura, Marcelo, Rehder, Patrícia M, Simone, Renata Z, Passini, Renato, Jr, Torrezan, Cristiano, Modena, João L P, Nunes dos Santos, Magnun N, Marba, Sergio T M, Zumpano dos Santos, Tábata R, Soeiro, Rachel E, Souza, Renato T, Bento, Silvana F, Cecatti, Jose G, Surita, Fernanda G, Freitas-Jesus, Juliana Vasconcellos, Pacagnella, Rodolfo C, Ribeiro-Do-Valle, Carolina C, Luz, Adriana G, Lajos, Giuliane J, Nobrega, Guilherme M, Griggio, Thayna B, Charles, Charles M, Silveira, Carla, Miele, Maria J, Tedesco, Ricardo P, Fernandes, Karayna G, Martins-Costa, Sérgio HA, Peret, Frederico JA, Feitosa, Francisco E, Traina, Evelyn, Cunha Filho, Edson V, Vettorazzi, Janete, Haddad, Samira M, Andreucci, Carla B, Guida, José P, Correa Junior, Mario D, Dias, Marcos AB, Oliveira, Leandro G, Melo Junior, Elias F, Luz, Marília GQ DA, and Costa, Maria Laura

Published
2024
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12. A rescue approach in refractory diffuse large B-cell lymphoma with obinutuzumab-redirected cytokine-induced killer cells: a first-in-human case report

Author

Francesca Elice, Roberta Sommaggio, Elisa Cappuzzello, Marcello Riva, Maria Chiara Tisi, Martina Bernardi, Angela Bozza, Daniela Catanzaro, Katia Chieregato, Anna Merlo, Ilaria Giaretta, Anna Dalla Pieta, Mauro Krampera, Carlo Visco, Livio Trentin, Andrea Visentin, Alberto Tosetto, Giuseppe Astori, and Antonio Rosato

Subjects
Diseases of the blood and blood-forming organs, RC633-647.5
Abstract

Not available.

Published
2024
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13. Tailored therapy with turoctocog alfa pegol according to patient’s lifestyle and hemorrhagic phenotype: from clinical trial to real-life

Author

Ilaria Nichele, Giuseppe Carli, and Alberto Tosetto

Subjects
haemophilia A, tailorized therapy, turoctocog alfa pegol, recombinant factor VIII, extended half-life, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Although the use of prophylaxis regimens with prolonged half-life factors is now widespread in the world of hemophilia A, there is a lack of real-life evidence on the impact of these products on joint health, adherence, and quality of life of patients. Turoctocog alfa pegol is a glycoPEGylated recombinant factor VIII (FVIII) with an extended half-life (EHL), developed for prophylaxis, treatment of bleeds, and perioperative management in patients with hemophilia A. We report here on three cases of three patients affected by severe hemophilia A, with variable bleeding phenotype and lifestyle, to describe our clinical practice on prophylaxis with turoctocog alfa pegol. As confirmed in our cases, FVIII trough levels remained coherent with those experienced in the registration trial after the switch to the commercial EHL drug. Moreover, the cases highlight how the current clinical management of hemophilia can personalize treatment in several specific conditions.

Published
2024

15. Inhibitor development according to concentrate after 50 exposure days in severe hemophilia: data from the European HAemophilia Safety Surveillance (EUHASS)

Author

Ay, Cihan, Male, Christoph, Hermans, Cedric, Verhamme, Peter, Lissitchkov, Toshko, Antoniades, Marios, Penka, Miroslav, Blatny, Jan, Komrska, Vladimir, Poulsen, Lone Hvitfeldt, Kampmann, Peter, Lehtinen, Anna-Elina, Susen, Sophie, Dargaud, Yesim, Biron, Christine, D'Oiron, Roseline, Harroche, Annie, Klamroth, Robert, Oldenburg, Johannes, Buehrlen, Martina, Miesbach, Wolfgang, Langer, Florian, Spannag, Patrick, Oliveri, Martin, Platokouki, Helen, Nomikou, Efrosyni, Katsarou, Olga, Garypidou, Vasileia, Economou, Marina, Nemes, Laszlo, Nolan, Beatrice, O'Connell, Niamh, Paolo, Radossi, Castaman, Giancarlo, Peyvandi, Flora, Rocino, Angiola, Zanon, Ezio, Tagliaferri, Annarita, Agnelli, Giancarlo, De Crisotofaro, Raimondo, Schinco, Piercarla, Tosetto, Alberto, Lejniece, Sandra, Gailiute, Neringa, Gatt, Alexander, Mäkelburg, Anja, Laros-van Gorkom, Britta, Brons, Paul, Leebeek, Frank W.G., Schutgens, Roger, Windyga, Jerzy, Catarino, Cristina, Aires, Anabela, Fraga, Cristina, Morais, Sara, Araújo, Fernando, Serban, Margit, Davydkin, Igor, Batorova, Angelika, Anzej Doma, Sasa, Martinez, Laura Segura, Palomo Bravo, Angeles, Ortega, Immaculada Soto, Bonanad, Santiago, Baghaei, Fariba, Astermark, Jan, Holmström, Margareta, Fontana, Pierre, Schmugge, Markus, Zulfikar, Bulent, Kavakli, Kaan, Khan, Mohammed, Benson, Gary, Lester, Will, Andrew, Page, Catherine, Bagot, Pinto, Fernando, Salta, Styliani, Farrelly, Cathy, Matthias, Mary, Laffan, Mike, Thynn Thynn, Yee, Mcdonald, Vickie, Austin, Steve, Bella, Madan, Hay, Charles, Grainger, John, Talks, Kate, Shapiro, Susie, Maclean, Rhona, Payne, Jeanette, Fischer, Kathelijn, Lassila, Riitta, Gouw, Samantha C., Hollingsworth, Rob, Lambert, Thierry, Kaczmarek, Radek, Carbonero, Diana, and Makris, Mike

Published
2024
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16. Thrombotic events associated with low baseline direct oral anticoagulant levels in atrial fibrillation: the MAS study

Author

Testa, Sophie, Dellanoce, Claudia, Paoletti, Oriana, Morandini, Rossella, Tala, Maurizio, Ciampa, Antonio, Gaeta, Martina, Chiarugi, Paolo, Casini, Monica, Guerri, Valentina, Santoro, Rita Carlotta, Iannaccaro, Piergiorgio, Iannone, Angela Maria, Campagna, Maddalena, De Candia, Erica, Alberelli, Maria Adele, Basso, Maria, De Cristofaro, Raimondo, Di Gennaro, Leonardo, Ferretti, Antonietta, Sorrentino, Silvia, Pignatelli, Pasquale, Menichelli, Danilo, Pastori, Daniele, Saliola, Mirella, Faioni, Elena Maria, Avarello, Ilaria, Razzari, Cristina, Chistolini, Antonio, Aprile, Simona Michela, Santoro, Cristina, Serrao, Alessandra, Esteban, Maria del Pilar, Ricca, Sergio, Marietta, Marco, Arletti, Laura, Coluccio, Valeria, Debbia, Giulia, Grisolia, Deborah, Serra, Domizio, Orselli, Alberto, Pescarollo, Alessandra, Verna, Sandra, Di Gregorio, Patrizia, Cassetti, Giuseppina, Molteni, Mauro, Monelli, Mauro, Paparo, Carmelo, Resani, Guido, Di Gregorio, Nicoletta, Grassi, Davide, Lodigiani, Corrado, Banfi, Elena, Ferrazzi, Paola, Librè, Luca, Pacetti, Veronica, Sacco, Clara, Bucciarelli, Paolo, Martinelli, Ida, Abbattista, Maria, Artoni, Andrea, Capecchi, Marco, Gianniello, Francesca, Scimeca, Barbara, Turrini, Anna, Moretta, Francesca, Parise, Giorgio, Zeccardo, Ciro, Fregoni, Vittorio, Balboni, Massimo, Leggio, Federico, Poli, Daniela, Ria, Luigi, Spagnolo, Marina, Dirienzo, Giovanni, Dirienzo, Lavinia, Fuzio, Diana, Donadini, Marco Paolo, Squizzato, Alessandro, Ageno, Walter, Colombo, Giovanna, Galliazzo, Silvia, Gallo, Andrea, Permunian, Eleonora Tamborini, Virano, Alexandra, Falanga, Anna, Barcella, Luca, Gamba, Sara, Lerede, Teresa, Maggioni, Anna, Russo, Laura, Schieppati, Francesca, Zunino, Federica, Barillari, Giovanni, Bertone, Antonella, Poz, Alessandra, Venturelli, Ugo, Serricchio, Giuseppina, Brevi, Francesca, Palareti, Gualtiero, Legnani, Cristina, Cini, Michela, Antonucci, Emilia, Tripodi, Armando, and Tosetto, Alberto

Published
2024
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17. Stains

Author

da Silva, Roberta Castilhos, Bevilaqua, Mariele, Santin, Juliana Tosetto, and Rangel Bonamigo, Renan, editor

Published
2023
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21. Association of sex with major bleeding risks in sub-Saharian anticoagulated patients with mechanical heart valves: A cohort study from the Khartoum Emergency Salam Centre.

Author

Erba, Nicoletta, Tosetto, Alberto, Abdallah, Suha Abdelwahab, Langer, Martin, Giovanella, Elena, Lentini, Salvatore, Masini, Franco, Mocini, Alessandro, Portella, Gennarina, Salvati, Alessandro Cristian, Squizzato, Alessandro, Testa, Sophie, Lip, Gregory Y.H., and Poli, Daniela

Published
2024
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22. Pelagic cnidarian assemblages show range-edge effect at the boundary of ocean surface, as illustrated in the case of the Amazon River Plume.

Author

Everton Giachini Tosetto, Sigrid Neumann-Leitão, Moacyr Araujo, Arnaud Bertrand, and Miodeli Nogueira Júnior

Subjects
Medicine, Science
Abstract

The neuston layer represents a complex community inhabiting the interface where oceanographic and atmospheric processes interact. Here, our aim was to compare patterns in the distribution and abundance of cnidarian assemblages observed in the neuston to parallel patterns previously observed in epipelagic waters along the spread of the Amazon River Plume over the Western Equatorial Atlantic, to test if the neuston reflects the patterns of the overall community whose core of distribution is located in epipelagic waters or are shaped by specific surface processes. The results show that both initial hypothesis were false. Instead, the cnidarian assemblages showed range-edge effect at the major ecotone placed at the interface between ocean and atmosphere. I.e., when proximate to the superior limits of their three-dimensional geographic ranges, represented here by the neuston, the population of most observed species occur in lower abundance. Specifically at the portion of the continental shelf with influence of the Amazon River Plume, the range-edge effect seems to be more prominent. Such results suggests the core of the cnidarian populations inhabiting this habit may lie in the deeper hypoxic waters beneath the plume. In conclusion, due the marked vertical structure observed here, proper evaluations of spatial patterns in the structure of pelagic cnidarian communities should preferentially be grounded on stratified sampling.

Published
2024
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23. A fish can change its stripes: investigating the role of body colour and pattern in the bluelined goatfish

Author

Louise Tosetto, Nathan S. Hart, and Jane E. Williamson

Subjects
Chromatic signal, Achromatic signal, Communication, Mullidae, Physiological colour change, Medicine, Biology (General), QH301-705.5
Abstract

Bluelined goatfish (Upeneichthys lineatus) rapidly change their body colour from a white horizontally banded pattern to a seemingly more conspicuous vertically banded red pattern, often when foraging. Given the apparent conspicuousness of the pattern to a range of observers, it seems unlikely that this colour change is used for camouflage and instead may be used for communication/signalling. Goatfish often drive multispecies associations, and it is possible that goatfish use this colour change as a foraging success signal to facilitate cooperation, increase food acquisition, and reduce predation risk through a ‘safety in numbers’ strategy. Using a novel approach, we deployed 3D model goatfish in different colour morphs—white without bands, white with black vertical bands, and white with red vertical bands—to determine whether the red colouration is an important component of the signal or if it is only the vertical banding pattern, regardless of colour, that fish respond to as an indicator of foraging success. Use of remote underwater video allowed us to obtain information without the influence of human observers on the communities and behaviours of other fish in response to these different colours exhibited by goatfish. We found that conspecifics were more abundant around the black- and red-banded model fish when compared with the white models. Conspecifics were also more likely to forage around the models than to pass or show attraction, but this was unaffected by model colour. No difference in the abundance and behaviour of associated heterospecifics around the different models was observed, perhaps due to the static nature of the models. Some species did, however, spend more time around the red- and black-banded fish, which suggests the change in colour may indicate benefits in addition to food resources. Overall, the results suggest that the body colour/pattern of U. lineatus is likely a signalling tool but further work is required to explore the benefits to both conspecifics and heterospecifics and to further determine the behavioural functions of rapid colour change in U. lineatus.

Published
2024
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27. Statins under-treatment and mortality in patients with atrial fibrillation. Insights from the nationwide START registry

Author

Testa, Sophie, Cosmi, Benilde, Guazzaloca, Giuliana, Migliaccio, Ludovica, Poli, Daniela, Marcucci, Rossella, Maggini, Niccolò, Pengo, Vittorio, Falanga, Anna, Lerede, Teresa, Ruocco, Lucia, Martini, Giuliana, Pedrini, Simona, Bertola, Federica, Masciocco, Lucilla, Saracino, Pasquale, Benvenuto, Angelo, Vasselli, Claudio, Violi, Francesco, Pignatelli, Pasquale, Pastori, Daniele, Grandone, Elvira, Colaizzo, Donatella, Marzolo, Marco, Pinelli, Mauro, Mastroiacovo, Daniela, Ageno, Walter, Colombo, Giovanna, Bucherini, Eugenio, Serra, Domizio, Toma, Andrea, Barbera, Pietro, Paparo, Carmelo, Insana, Antonio, Rupoli, Serena, Malcangi, Giuseppe, Zighetti, Maddalena Loredana, Mangione, Catello, Lione, Domenico, Casasco, Paola, Nante, Giovanni, Tosetto, Alberto, Oriana, Vincenzo, Liberato, Nicola Lucio, Menichelli, Danilo, Antonucci, Emilia, and Palareti, Gualtiero

Published
2023
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28. Butyrate limits human natural killer cell effector function

Author

Vanessa Zaiatz-Bittencourt, Fiona Jones, Miriam Tosetto, Caitriona Scaife, Gerard Cagney, Evan Jones, Glen A. Doherty, and Elizabeth J. Ryan

Subjects
Medicine, Science
Abstract

Abstract The gut microbiota regulates chronic inflammation and has been implicated in the pathogenesis of a broad spectrum of disease including autoimmunity and cancer. Microbial short-chain fatty acids (SCFAs) e.g., butyrate have demonstrated immunomodulatory effects and are thought to be key mediators of the host-microbiome interaction. Here, we investigated the effect of butyrate on effector functions of blood derived human NK cells stimulated for 18 h with a combination of IL-12/IL-15, a potent mix of cytokines that drive NK cell activation. We show that butyrate has a strong anti-inflammatory effect on NK cells. NK cells cultured in the presence of butyrate expressed lower levels of activating receptors (TRAIL, NKp30, NKp44) and produced lower levels of cytokines (IFNγ, TNF-α, IL-22, granzyme B, granzyme A, perforin) in response to IL-12/IL-15. Butyrate restricted NK cell function by downregulation of mTORC1 activity, c-Myc mRNA expression and metabolism. Using a shotgun proteomic approach, we confirmed the effect of butyrate on NK cell cytokine signaling and metabolism and identified BRD2, MAT2A and EHD1 as downstream mediators of these effects. This insight into the immunomodulatory activity of butyrate on human NK cell function might help to develop new ways to limit NK cell function during chronic inflammation.

Published
2023
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29. Pentafecta outcomes of robotic laparoscopically assisted radical prostatectomy during the initial experience in a university hospital

Author

Eduardo Tosetto Cachoeira, Artur de Oliveira Paludo, Pedro Glusman Knijnik, Pietro Waltrick Brum, Lucas Medeiros Burttet, Milton Berger, and Brasil Silva Neto

Subjects
Pentafecta, Prostatectomy, Robotic, Continence, Initial experience, Diseases of the genitourinary system. Urology, RC870-923
Abstract

Abstract Background Robotic laparoscopically assisted radical prostatectomy (RARP) is an option for the treatment of localized prostate cancer. The objective of the present study was to evaluate the pentafecta outcomes (biochemical recurrence, continence, potency, surgical complications and surgical margins) in patients undergoing RARP during the initial experience in a university hospital. Methods This is a retrospective study of patients who had RARP for localized prostate adenocarcinoma at a university hospital from August 2013 to October 2019 to evaluate pentafecta outcomes (biochemical recurrence, continence, potency, surgical complications and surgical margins). Data were collected and stored via Microsoft Office Excel program and analyzed using SPSS Software, version 20.0. Results One hundred and sixty-three RARP were performed, the mean age is 64.16 ± 6.54 years, PSA 6.20 (IQR = 4.91–8.95) ng/dl, BMI 27.14 (IQR = 24.22–29.26) kg/m2, D’Amico risk classification was 35 (22.3%) low risk, 81 (51.6%) intermediate risk and 41 (26.1%) high risk. One hundred and fifty-four patients entered the analysis of pentafecta with a rate of 38.3% reaching this outcome. Complications: Twenty-three (14.1%) patients had minor complications (Clavien I and II) and eight patients had major complications (Clavien IIIa, IIIb and IVa). Surgical margins were negative in 69.9% of patients. The biochemical recurrence-free rate was 89.5%. The overall continence rate was 93.5%, and the potency rate was 63.5%. Multivariate analysis showed that T2 patients are 2.7 times more likely to achieve pentafecta outcome than patients ≥ T3 (p

Published
2023
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30. Venous thromboembolism secondary to hospitalization for COVID-19: patient management and long-term outcomes

Author

Ageno, Walter, Girardi, Laura, Sterpone, Paola, Cosmi, Benilde, Bucherini, Eugenio, Chistolini, Antonio, Serrao, Alessandra, Di Nisio, Marcello, Potere, Nicola, Porreca, Ettore, Fregoni, Vittorio, Grandone, Elvira, Colaizzo, Donatella, Insana, Antonio, Lerede, Teresa, Falanga, Anna, Martinelli, Ida, Bucciarelli, Paolo, Abbattista, Maria, Martini, Giuliana, Masciocco, Lucilla, Mastroiacovo, Daniela, Pancani, Roberta, Carrozzi, Laura, Paparo, Carmelo, Pedrini, Simona, Pieralli, Filippo, Milia, Alessandro, Pignatelli, Pasquale, Menichelli, Danilo, Pizzini, Attilia Maria, Silingardi, Mauro, Podda, GianMarco, Birocchi, Simone, Poli, Daniela, Crudele, Felice, Lotti, Elena, Marcucci, Rossella, Preti, Paola Stefania, Sarti, Luca, Trovati, Alice, Caronna, Antonella, Famiglietti, Elena, Lami, Francesca, Nicolini, Alberto, Scaglioni, Federica, Testa, Sophie, Paoletti, Oriana, Tosetto, Alberto, Toma, Andrea, Villalta, Sabina, Visonà, Adriana, Zalunardo, Beniamino, Panzavolta, Chiara, Antonucci, Emilia, Podda, Gian Marco, and Palareti, Gualtiero

Published
2023
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31. von Willebrand factor neutralizing and non-neutralizing alloantibodies in 213 subjects with type 3 von Willebrand disease enrolled in 3WINTERS-IPS

Author

Pagliari, Maria Teresa, Budde, Ulrich, Baronciani, Luciano, Eshghi, Peyman, Ahmadinejad, Minoo, Badiee, Zahra, Baghaipour, Mohammad-Reza, Benítez Hidalgo, Olga, Biguzzi, Eugenia, Bodó, Imre, Castaman, Giancarlo, Goudemand, Jenny, Karimi, Mehran, Keikhaei, Bijan, Lassila, Riitta, Leebeek, Frank W.G., Lopez Fernandez, Maria Fernanda, Marino, Renato, Oldenburg, Johannes, Peake, Ian, Santoro, Cristina, Schneppenheim, Reinhard, Tiede, Andreas, Toogeh, Gholamreza, Tosetto, Alberto, Trossaert, Marc, Yadegari, Hamideh, Zetterberg, Eva M.K., Mannucci, Pier Mannuccio, Federici, Augusto B., Eikenboom, Jeroen, and Peyvandi, Flora

Published
2023
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34. 36-month clinical outcomes of patients with venous thromboembolism: GARFIELD-VTE

Author

Loualidi, Ab, Colak, Abdurrahim, Bezuidenhout, Abraham, Abdool-Carrim, Abu, Azeddine, Addala, Beyers, Adriaan, Dees, Adriaan, Mohamed, Ahmed, Aksoy, Ahmet, Abiko, Akihiko, Watanabe, Akinori, Krichell, Alan, Fernandez, Alberto Alfredo, Tosetto, Alberto, Khotuntsov, Alexey, Oropallo, Alisha, Slocombe, Alison, Kelly, Allan, Clark, Amanda, Gad, Amr, Arouni, Amy, Schmidt, Andor, Berni, Andrea, Kleiban, Andres Javier, Machowski, Andrew, Kazakov, Andrey, Galvez, Angel, Lockman, Ann, Falanga, Anna, Chauhan, Anoop, Riera-Mestre, Antoni, Mazzone, Antonino, D'Angelo, Armando, Herdy, Artur, Kato, Atsushi, Salem, Ayman Abd Elhamid Ebrahim Mahmoud, Husin, Azlan, Erdelyi, Barbara, Jacobson, Barry, Amann-Vesti, Beatrice, Battaloglu, Bektas, Wilson, Benedicte, Cosmi, Benilde, Francois, Bergmann Jean, Toufek, Berremeli, Hunt, Beverley, Natha, Bhavesh, Mustafa, Bisher, Kho, Bonnie Chi Shan, Carine, Boulon, Zidel, Brian, Dominique, Brisot, Christophe, Brousse, Trimarco, Bruno, Luo, Canhua, Cuneo, Carlos Alberto, Diaz, Carlos Jerjes Sanchez, Schwencke, Carsten, Cader, Cas, Yavuz, Celal, Zaidman, Cesar Javier, Lunn, Charles, Wu, Chau-Chung, Toh, Cheng Hock, Chiang, Chern-En, Elisa, Chevrier, Hsia, Chien-Hsun, Huang, Chien-Lung, Kwok, Chi-Hang Kevin, Wu, Chih-Cheng, Huang, Chi-Hung, Ward, Chris, Opitz, Christian, Jeanneret-Gris, Christina, Ha, Chung Yin, Huang, Chun-Yao, Bidi, Claude Luyeye, Smith, Clifford, Brauer, Cornelia, Lodigiani, Corrado, Francis, Couturaud, Wu, Cynthia, Staub, Daniel, Theodoro, Daniel, Poli, Daniela, Acevedo, David - Riesco, Adler, David, Jimenez, David, Keeling, David, Scott, David, Imberti, Davide, Creagh, Desmond, Helene, Desmurs-Clavel, Hagemann, Dirk, Le Roux, Dirk, Skowasch, Dirk, Belenky, Dmitry, Dorokhov, Dmitry, Petrov, Dmitry, Zateyshchikov, Dmitry, Prisco, Domenico, Møller, Dorthe, Kucera, Dusan, Esheiba, Ehab M., Panchenko, Elizaveta, Dominique, Elkouri, Dogan, Emre, Kubat, Emre, Diaz, Enrique Diaz, Tse, Eric Wai Choi, Yeo, Erik, Hashas, Erman, Grochenig, Ernst, Tiraferri, Eros, Blessing, Erwin, Michèle, Escande Orthlieb, Usandizaga, Esther, Porreca, Ettore, Ferroni, Fabian, Nicolas, Falvo, Ayala-Paredes, Félix, Koura, Firas, Henry, Fitjerald, Cosmi, Franco, Erdkamp, Frans, Kamalov, Gadel, Dalmau, Garcia-Bragado, Damien, Garrigues, Klein, Garry, Shah, Gaurand, Hollanders, Geert, Merli, Geno, Plassmann, Georg, Platt, George, Poirier, Germain, Sokurenko, German, Haddad, Ghassan, Ali, Gholam, Agnelli, Giancarlo, Gan, Gin Gin, Kaye-Eddie, Grace, Le Gal, Gregoire, Allen, Gregory, Esperón, Guillermo Antonio Llamas, Jean-Paul, Guillot, Gerofke, Hagen, Elali, Hallah, Burianova, Hana, Ohler, Hans-Juergen, Wang, Haofu, Darius, Harald, Gogia, Harinder S., Striekwold, Harry, Gibbs, Harry, Hasanoglu, Hatice, Turker, Hatice, Franow, Hendrik, Bounameaux, Henri, De Raedt, Herbert, Schroe, Herman, ElDin, Hesham Salah, Zidan, Hesham, Nakamura, Hiroaki, Kim, Ho Young, Lawall, Holger, Zhu, Hong, Tian, Hongyan, Yhim, Ho-Young, ten Cate, Hugo, Hwang, Hun Gyu, Shim, Hyeok, Kim, Igor, Libov, Igor, Sonkin, Igor, Suchkov, Igor, Song, Ik-Chan, Kiris, Ilker, Staroverov, Ilya, Looi, Irene, De La Azuela Tenorio, Isabel M., Savas, Ismail, Gordeev, Ivan, Podpera, Ivo, Lee, Jae Hoon, Sathar, Jameela, Welker, James, Beyer-Westendorf, Jan, Kvasnicka, Jan, Vanwelden, Jan, Kim, JangYong, Svobodova, Jaromira, Gujral, Jaspal, Marino, Javier, Galvar, Javier Tristan, Kassis, Jeannine, Kuo, Jen-Yuan, Shih, Jhih-Yuan, Kwon, JiHyun, Joh, Jin Hyun, Park, Jin Hyun, Kim, Jin Seok, Yang, Jinghua, Krupicka, Jiri, Lastuvka, Jiri, Pumprla, Jiri, Vesely, Jiri, Souto, Joan Carlos, Correa, João Antônio, Duchateau, Johan, Fletcher, John Perry, del Toro, Jorge, Paez, Jorge Guillermo Chavez, Nielsen, Jørn, Filho, Jose Dalmo Araujo, Saraiva, Jose, Peromingo, Jose Antonio Diaz, Lara, Jose Gomez, Fedele, Jose Luis, Surinach, Jose Maria, Chacko, Joseph, Muntaner, Juan Antonio, Benitez, Juan Carlos Álvarez, Abril, Juan Moreno Hoyos, Humphrey, Julian, Bono, Julio, Kanda, Junji, Boondumrongsagoon, Juree, Yiu, Kai Hang, Chansung, Kanchana, Boomars, Karin, Burbury, Kate, Kondo, Katsuhiro, Karaarslan, Kemal, Takeuchi, Kensuke, Kroeger, Knut, Zrazhevskiy, Konstantin, Svatopluk, Koscál, Shyu, Kou-Gi, Vandenbosch, Kristel, Chang, Kuan-Cheng, Chiu, Kuan-Ming, Jean-Manuel, Kubina, Wern, Kwan Jing, Ueng, Kwo-Chang, Norasetthada, Lalita, Binet, Laure, Chew, Lee Ping, Zhang, Lei, Cristina, Leone Maria, Tick, Lidwine, Schiavi, Lilia Beatriz, Wong, Lily Lee Lee, Borges, Lohana, Botha, Louis, Capiau, Luc, Timmermans, Luc, López, Luciano Eduardo, Ria, Luigi, Blasco, Luis Manuel Hernandez, Guzman, Luis Alberto, Cervera, Luis Flota, Isabelle, Mahe, Bosch, Manuel Monreal, de los Rios Ibarra, Manuel, Fernandez, Manuel Núñez, Carrier, Marc, Barrionuevo, Marcelo Raul, Gamba, Marco Antonio Alcocer, Cattaneo, Marco, Moia, Marco, Bowers, Margaret, Chetanachan, Mariam, Berli, Mario Alberto, Fixley, Mark, Faghih, Markus, Stuecker, Markus, Schul, Marlin, Banyai, Martin, Koretzky, Martin, Myriam, Martin, Gaffney, Mary Elizabeth, Hirano, Masao, Kanemoto, Masashi, Nakamura, Mashio, Tahar, Mersel, Emmanuel, Messas, Kovacs, Michael, Leahy, Michael, Levy, Michael, Munch, Michael, Olsen, Michael, De Pauw, Michel, Gustin, Michel, Van Betsbrugge, Michiel, Boyarkin, Mikhail, Homza, Miroslav, Koto, Modise, Abdool-Gaffar, Mohamed, Nagib, Mohamed Ayman Fakhry, El-Dessoki, Mohamed, Khan, Mohamed, Mohamed, Monniaty, Kim, Moo Hyun, Lee, Moon-Hee, Soliman, Mosaad, Ahmed, Mostafa Shawky, el Bary, Mostafa Soliman Abd, Moustafa, Moustafa A., Hameed, Muhammad, Kanko, Muhip, Majumder, Mujibur, Zubareva, Nadezhda, Mumoli, Nicola, Abdullah, Nik Azim Nik, Makruasi, Nisa, Paruk, Nishen, Kanitsap, Nonglak, Duda, Norberto, Nordin, Nordiana, Nyvad, Ole, Barbarash, Olga, Gurbuz, Orcun, Vilamajo, Oscar Gomez, Flores, Oscar Nandayapa, Gur, Ozcan, Oto, Oztekin, Marchena, Pablo Javier, Angchaisuksiri, Pantep, Carroll, Patrick, Lang, Pavel, MacCallum, Peter, von Bilderling, Peter Baron, Blombery, Peter, Verhamme, Peter, Jansky, Petr, Bernadette, Peuch, De Vleeschauwer, Philippe, Hainaut, Philippe, Ferrini, Piera Maria, Iamsai, Piriyaporn, Christian, Ponchaux, Viboonjuntra, Pongtep, Rojnuckarin, Ponlapat, Ho, Prahlad, Mutirangura, Pramook, Wells, Rachel, Martinez, Rafael, Miranda, Raimundo Tirado, Kroening, Ralf, Ratsela, Rapule, Reyes, Raquel Lopez, de Leon, Raul Franco Diaz, Wong, Raymond Siu Ming, Alikhan, Raz, Jerwan-Keim, Reinhold, Otero, Remedios, Murena-Schmidt, Renate, Canevascini, Reto, Ferkl, Richard, White, Richard, Van Herreweghe, Rika, Santoro, Rita, Klamroth, Robert, Mendes, Robert, Prosecky, Robert, Cappelli, Roberto, Spacek, Rudolf, Singh, Rupesh, Griffin, Sam, Na, Sang Hoon, Chunilal, Sanjeev, Middeldorp, Saskia, Nakazawa, Satoshi, Schellong, Sebastian, Toh, See Guan, Christophe, Seinturier, Isbir, Selim, Raymundo, Selma, Ting, Seng Kiat, Motte, Serge, Aktogu, Serir Ozkan, Donders, Servaas, Cha, Seung Ick, Nam, Seung-Hyun, Marie-Antoinette, Sevestre-Pietri, Maasdorp, Shaun, Sun, Shenghua, Wang, Shenming, Essameldin, Sherif Mohamed, Sholkamy, Sherif Mohamed, Kuki, Shintaro, Goto, Shinya, Yoshida, Shuichi, Matsuoka, Shunzo, McRae, Simon, Watt, Simon, Patanasing, Siriwimon, Jean-Léopold, Siwe-Nana, Wongkhantee, Somchai, Bang, Soo-Mee, Testa, Sophie, Zemek, Stanislav, Behrens, Steffen, Dominique, Stephan, Mellor, Stuart, Singh, Suaran Singh Gurcharan, Datta, Sudip, Chayangsu, Sunee, Solymoss, Susan, Everington, Tamara, Abdel-Azim, Tarek Ahmed Adel, Suwanban, Tawatchai, Adademir, Taylan, Hart, Terence, Béatrice, Terriat, Luvhengo, Thifhelimbilu, Horacek, Thomas, Zeller, Thomas, Boussy, Tim, Reynolds, Tim, Biss, Tina, Chao, Ting-Hsing, Casabella, Tomas Smith, Onodera, Tomoya, Numbenjapon, Tontanai, Gerdes, Victor, Cech, Vladimir, Krasavin, Vladimir, Tolstikhin, Vladimir, Bax, W.A., Malek, Wagih Fawzy Abdel, Ho, Wai Khoon, Ageno, Walter, Pharr, Walter, Jiang, Weihong, Lin, Wei-Hsiang, Zhang, Weihua, Tseng, Wei-Kung, Lai, Wen-Ter, De Backer, Wilfried, Haverkamp, Wilhelm, Yoshida, Winston, Korte, Wolfgang, Choi, Won Il, Kim, Yang-Ki, Tanabe, Yasuhiro, Ohnuma, Yasushi, Mun, Yeung-Chul, Balthazar, Yohan, Park, Yong, Shibata, Yoshisato, Burov, Yuriy, Subbotin, Yuriy, Coufal, Zdenek, Yang, Zhenwen, Jing, Zhicheng, Yang, Zhongqi, Turpie, Alexander G.G., Farjat, Alfredo E., Haas, Sylvia, Weitz, Jeffrey I., Goldhaber, Samuel Z., Kayani, Gloria, Lopes, Renato D., Tse, Eric, Muntaner, Juan, Prandoni, Paolo, Maheshwari, Uma, and Kakkar, Ajay K.

Published
2023
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35. Planktonic cnidarian responses to contrasting thermohaline and circulation seasonal scenarios in a tropical western boundary current system

Author

E. Giachini Tosetto, A. Bertrand, S. Neumann-Leitão, A. Costa da Silva, and M. Nogueira Júnior

Subjects
Geography. Anthropology. Recreation, Environmental sciences, GE1-350
Abstract

In western boundary current systems (WBCSs), strong currents flow coastward carrying oceanic water masses and their associated planktonic fauna. Variation in the intensity of these currents and in the continental runoff may affect the dynamic interplay between oceanic and coastal communities. In addition, changes in the continental runoff and the thermohaline structure modulate the primary production, adding complexity to the dynamics of these oligotrophic systems. These dynamics likely shape the planktonic cnidarian communities. To further understand such relationships, we used a comprehensive dataset encompassing samples collected above the shelf and slope and around oceanic seamounts and islands of the Fernando de Noronha Ridge in the western tropical South Atlantic, in two seasons characterised by distinct thermohaline structure and circulation patterns. Results show that in the tropical South Atlantic and, likely, other western boundary systems with narrow continental shelves, coastward currents spread oceanic waters and their associated cnidarian species over the continental shelf. However, while both coastal and oceanic communities co-occur when the continental runoff is notable, oceanic species dominate almost the entire shelf during the dry season characterised by a stronger boundary current intensity. We also conclude that when the mixed-layer depth and associated nutricline are shallower, the enhanced primary productivity supports larger populations of planktonic cnidarian species through a bottom–up control.

Published
2022
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36. Dynamic colour change as a signalling tool in bluelined goatfish (Upeneicthtys lineatus)

Author

Louise Tosetto, Nathan S. Hart, and Jane E. Williamson

Subjects
communication, foraging signal, goatfishes, Mullidae, physiological colour change, Ecology, QH540-549.5
Abstract

Abstract Many animal species can rapidly change their body colouration and patterning, but often the ecological drivers of such changes are unknown. Here, we explored dynamic colour change in the bluelined goatfish, Upeneichthys lineatus, a temperate marine teleost species. Upeneichthus lineatus can change in a matter of seconds, from a uniform white colour to display prominent, vertical, dark red stripes. Initial observations suggested that rapid colour change in U. lineatus was associated with feeding and may act as a signal to both conspecifics and heterospecifics that are frequently observed to follow feeding goatfish. Field observations of the colour and behaviour of individual U. lineatus were collected to (1) document the repertoire of behaviours that U. lineatus displays and categorise associated colour patterns; (2) quantify the speed of dynamic colour change; (3) establish the context in which U. lineatus changes colour and pattern; and (4) test whether the behaviour of follower fishes is influenced by colour patterning or specific behaviours of the focal goatfish. We found that U. lineatus changed colouration from white to the red banded pattern in less than 10 s. The key driver of rapid colour change in U. lineatus was feeding, particularly when the fish fed with its head buried in sediment. Conspecific followers were most likely to be white in colour and adopt searching behaviour, regardless of the focal fish colour or behaviour. Other species of follower fish spent significantly more time following U. lineatus that were displaying dark red stripes when searching or eating, implying the red stripes may be an interspecific signalling mechanism. Our findings indicate that rapid colour change in teleost fish may be used for social communication and may provide U. lineatus with increased protection from predation when feeding via a safety‐in‐numbers approach.

Published
2023
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37. P1183: CENTRAL NERVOUS SYSTEM INVOLVEMENT AT DIAGNOSIS AND AT RELAPSE IN PATIENTS WITH PERIPHERAL T-CELL LYMPHOMA: A RETROSPECTIVE ANALYSIS OF THE 'RETE EMATOLOGICA VENETA' (T-REV PROJECT).

Author

Marcello Riva, Maria Chiara Tisi, Davide Facchinelli, Greta Scapinello, Alberto Schena, Dario Marino, Silvia Finotto, Leila Romano, Maurizio Cavallari, Carlo Borghero, Renato Bassan, Mauro Krampera, Filippo Gherlinzoni, Livio Trentin, Alberto Tosetto, Piero Maria Stefani, Francesco Piazza, and Carlo Visco

Subjects
Diseases of the blood and blood-forming organs, RC633-647.5
Published
2023
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41. KH-Type Splicing Regulatory Protein Controls Colorectal Cancer Cell Growth and Modulates the Tumor Microenvironment

Author

Caiazza, Francesco, Oficjalska, Katarzyna, Tosetto, Miriam, Phelan, James J, Noonan, Sinéad, Martin, Petra, Killick, Kate, Breen, Laura, O'Neill, Fiona, Nolan, Blathnaid, Furney, Simon, Power, Robert, Fennelly, David, Craik, Charles S, O'Sullivan, Jacintha, Sheahan, Kieran, Doherty, Glen A, and Ryan, Elizabeth J

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Colo-Rectal Cancer, Cancer, Digestive Diseases, Aetiology, 2.1 Biological and endogenous factors, Adult, Aged, Aged, 80 and over, Apoptosis, Biomarkers, Tumor, Cell Proliferation, Cell Transformation, Neoplastic, Colorectal Neoplasms, Female, Follow-Up Studies, Gene Expression Regulation, Neoplastic, Humans, Male, Middle Aged, Prognosis, RNA-Binding Proteins, Survival Rate, Trans-Activators, Tumor Cells, Cultured, Tumor Microenvironment, Xenograft Model Antitumor Assays, Medical and Health Sciences, Pathology, Biomedical and clinical sciences, Health sciences
Abstract

KH-type splicing regulatory protein (KHSRP) is a multifunctional nucleic acid binding protein implicated in key aspects of cancer cell biology: inflammation and cell-fate determination. However, the role KHSRP plays in colorectal cancer (CRC) tumorigenesis remains largely unknown. Using a combination of in silico analysis of large data sets, ex vivo analysis of protein expression in patients, and mechanistic studies using in vitro models of CRC, we investigated the oncogenic role of KHSRP. We demonstrated KHSRP expression in the epithelial and stromal compartments of both primary and metastatic tumors. Elevated expression was found in tumor versus matched normal tissue, and these findings were validated in larger independent cohorts in silico. KHSRP expression was a prognostic indicator of worse overall survival (hazard ratio, 3.74; 95% CI, 1.43-22.97; P = 0.0138). Mechanistic data in CRC cell line models supported a role of KHSRP in driving epithelial cell proliferation in both a primary and metastatic setting, through control of the G1/S transition. In addition, KHSRP promoted a proangiogenic extracellular environment by regulating the secretion of oncogenic proteins involved in diverse cellular processes, such as migration and response to cellular stress. Our study provides novel mechanistic insight into the tumor-promoting effects of KHSRP in CRC.

Published
2019

42. Notulae to the Italian alien vascular flora: 13

Author

Gabriele Galasso, Gianniantonio Domina, Claudia Angiolini, Dario Azzaro, Gianluigi Bacchetta, Enrico Banfi, Davide Barberis, Giulio Barone, Fabrizio Bartolucci, Alessio Bertolli, Rossano Bolpagni, Gianmaria Bonari, Luca Bracchetti, Giacomo Calvia, Giuliano Campus, Laura Cancellieri, Viviana Cavallaro, Fabio Conti, Alba Cuena-Lombraña, Evelina D’Alessandro, Giusy Dal Corso, Alice Dalla Vecchia, Antonino De Natale, Emanuele Del Guacchio, Giuseppe Di Gregorio, Emilio Di Gristina, Mario Di Stefano, Emanuele Fanfarillo, Alessandro Federici, Germano Federici, Giulio Ferretti, Francesco Festi, Tiberio Fiaschi, Goffredo Filibeck, Mauro Fois, Luca Gariboldi, Giovanni Gestri, Leonardo Gubellini, Alessandro Guiggi, Nicole Hofmann, Valentina L.A. Laface, Andrea Lallai, Valerio Lazzeri, Angela P. Lecis, Michele Lonati, Fernando Lucchese, Jacopo Lupoletti, Samuele Maestri, Andrea Mainetti, Francesca Mantino, Francesco Mascia, Rizzieri R. Masin, Giacomo Mei, Marco Merli, Antonino Messina, Carmelo M. Musarella, Ginevra Nota, Nicola Olivieri, Bruno Paura, Roberto Pellegrini, Antonio Pica, Marco Pittarello, Lina Podda, Safiya Praleskouskaya, Filippo Prosser, Giuseppe Ratini, Simone Ravetto Enri, Francesco Roma-Marzio, Giovanni Salerno, Alberto Selvaggi, Adriano Soldano, Giovanni Spampinato, Adriano Stinca, Federico M. Tardella, Gianmarco Tavilla, Valeria Tomaselli, Giulia Tomasi, Luca Tosetto, Roberto Venanzoni, and Lorenzo Lastrucci

Subjects
Botany, QK1-989
Abstract

In this contribution, new data concerning the distribution of vascular flora alien to Italy are presented. It includes new records, confirmations, exclusions, and status changes for Italy or for Italian administrative regions. Nomenclatural and distribution updates published elsewhere are provided as Suppl. material 1.

Published
2022
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43. Rivaroxaban for the treatment of noncirrhotic splanchnic vein thrombosis: an interventional prospective cohort study

Author

Ageno, Walter, Beyer Westendorf, Jan, Contino, Laura, Bucherini, Eugenio, Sartori, Maria Teresa, Senzolo, Marco, Grandone, Elvira, Santoro, Rita, Carrier, Marc, Delluc, Aurélien, De Stefano, Valerio, Pomero, Fulvio, Donadini, Marco Paolo, Tosetto, Alberto, Becattini, Cecilia, Martinelli, Ida, Nardo, Barbara, Bertoletti, Laurent, Di Nisio, Marcello, Lazo-Langner, Alejandro, Schenone, Alessandro, and Riva, Nicoletta

Published
2022
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44. Von Willebrand factor propeptide and pathophysiological mechanisms in European and Iranian patients with type 3 von Willebrand disease enrolled in the 3WINTERS‐IPS study

Author

Pagliari, Maria Teresa, Rosendaal, Frits R., Ahmadinejad, Minoo, Badiee, Zahra, Baghaipour, Mohammad‐Reza, Baronciani, Luciano, Benítez Hidalgo, Olga, Bodó, Imre, Budde, Ulrich, Castaman, Giancarlo, Eshghi, Peyman, Goudemand, Jenny, Karimi, Mehran, Keikhaei, Bijan, Lassila, Riitta, Leebeek, Frank W.G., Lopez Fernandez, Maria Fernanda, Mannucci, Pier Mannuccio, Marino, Renato, Oldenburg, Johannes, Peake, Ian, Santoro, Cristina, Schneppenheim, Reinhard, Tiede, Andreas, Toogeh, Gholamreza, Tosetto, Alberto, Trossaert, Marc, Yadegari, Hamideh, Zetterberg, Eva M.K., Peyvandi, Flora, Federici, Augusto B., and Eikenboom, Jeroen

Published
2022
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45. Pelagic cnidarian assemblages show range-edge effect at the boundary of ocean surface, as illustrated in the case of the Amazon River Plume.

Author

Tosetto, Everton Giachini, Neumann-Leitão, Sigrid, Araujo, Moacyr, Bertrand, Arnaud, and Júnior, Miodeli Nogueira

Subjects
*REGIONS of freshwater influence, *CONTINENTAL shelf, *ECOTONES, *OCEAN, *HABIT
Abstract

The neuston layer represents a complex community inhabiting the interface where oceanographic and atmospheric processes interact. Here, our aim was to compare patterns in the distribution and abundance of cnidarian assemblages observed in the neuston to parallel patterns previously observed in epipelagic waters along the spread of the Amazon River Plume over the Western Equatorial Atlantic, to test if the neuston reflects the patterns of the overall community whose core of distribution is located in epipelagic waters or are shaped by specific surface processes. The results show that both initial hypothesis were false. Instead, the cnidarian assemblages showed range-edge effect at the major ecotone placed at the interface between ocean and atmosphere. I.e., when proximate to the superior limits of their three-dimensional geographic ranges, represented here by the neuston, the population of most observed species occur in lower abundance. Specifically at the portion of the continental shelf with influence of the Amazon River Plume, the range-edge effect seems to be more prominent. Such results suggests the core of the cnidarian populations inhabiting this habit may lie in the deeper hypoxic waters beneath the plume. In conclusion, due the marked vertical structure observed here, proper evaluations of spatial patterns in the structure of pelagic cnidarian communities should preferentially be grounded on stratified sampling. [ABSTRACT FROM AUTHOR]

Published
2024
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47. Surgical management of patients with von Willebrand disease: summary of 2 systematic reviews of the literature

Author

Brignardello-Petersen, Romina, El Alayli, Abdallah, Husainat, Nedaa, Kalot, Mohamad, Shahid, Shaneela, Aljabirii, Yazan, Britt, Alec, Alturkmani, Hani, El-Khechen, Hussein, Motaghi, Shahrzad, Roller, John, Dimassi, Ahmad, Abughanimeh, Omar, Madoukh, Bader, Arapshian, Alice, Grow, Jean M., Kouides, Peter, Laffan, Michael, Leebeek, Frank W.G., O'Brien, Sarah H., Tosetto, Alberto, James, Paula D., Connell, Nathan T., Flood, Veronica, and Mustafa, Reem A.

Published
2022
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48. D-dimer and reduced-dose apixaban for extended treatment after unprovoked venous thromboembolism: the Apidulcis study

Author

Palareti, Gualtiero, Poli, Daniela, Ageno, Walter, Legnani, Cristina, Antonucci, Emilia, Bucherini, Eugenio, Testa, Sophie, Paoletti, Oriana, Chistolini, Antonio, Serrao, Alessandra, Martinelli, Ida, Bucciarelli, Paolo, Falanga, Anna, Tosetto, Alberto, Sarti, Luca, Mastroiacovo, Daniela, Cosmi, Benilde, Visonà, Adriana, Santoro, Rita Carlotta, Zanatta, Nello, Grandone, Elvira, Bertù, Lorenza, Pengo, Vittorio, Caiano, Lucia, and Prandoni, Paolo

Published
2022
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49. The Amazon River plume, a barrier to animal dispersal in the Western Tropical Atlantic

Author

Everton Giachini Tosetto, Arnaud Bertrand, Sigrid Neumann-Leitão, and Miodeli Nogueira Júnior

Subjects
Medicine, Science
Abstract

Abstract The dispersal of marine organisms can be restricted by a set of isolation mechanisms including hard barriers or hydrological features. In the Western Atlantic Ocean, the Amazon River discharge has been shown to act as a biogeographical barrier responsible for the differences in reef fish communities between Caribbean Sea and Northeast Brazil continental shelves. Here, we compare the diversity of all Animalia phyla from biogeographic ecoregions along the Tropical Western Atlantic continental shelf to test the hypothesis that the Amazon River plume spatially structures species diversity. For that, we used beta diversity estimators and multivariate ecological analysis on a database of species occurrence of the whole animal kingdom including 175,477 occurrences of 8,375 species from six ecoregions along the Western Tropical Atlantic. Results of the whole animal kingdom and the richest phyla showed that the Caribbean Sea and Tropical Brazil ecoregions are isolated by the Amazon River Plume, broadening and confirming the hypothesis that it acts as a soft barrier to animal dispersal in the Western Tropical Atlantic. Species sharing is larger northwestwards, in direction of the Caribbean than the opposite direction. Beyond species isolation due to local characteristics such as low salinity and high turbidity, our results suggest the dominant northwestward currents probably play a major role in animal dispersion: it enhances the flux of larvae and other planktonic organisms with reduced mobility from Brazil to Caribbean and hinders their contrary movement. Thus, the Amazon area is a strong barrier for taxa with reduced dispersal capacity, while species of pelagic taxa with active swimming may transpose it more easily.

Published
2022
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50. Amazon River plume habitats shape planktonic cnidarian assemblages in the Western Atlantic.

Author

Everton Giachini Tosetto, Sigrid Neumann-Leitão, Moacyr Araujo, Djoirka Minto Dimoune, Arnaud Bertrand, and Miodeli Nogueira Júnior

Subjects
Medicine, Science
Abstract

The impact of the Amazon River freshwater plume on planktonic cnidarians over neritic and oceanic provinces is unknown. To provide further knowledge we took advantage of an oceanographic cruise performed in October 2012 in the Western Atlantic off the North Brazilian coast (8°N, 51°W-3.5°S, 37°W). A complex and dynamic system was observed, with strong currents and eddies dispersing the plume over a large area. Our results show that the Amazon River shapes marine habitats with a thin highly productive surface layer compressed by a deeper oxygen minimum zone both over the shelf and in the open ocean. We hypothesized that such habitat structure is particularly advantageous to planktonic cnidarians, which have low metabolic rates, being able to survive in hypoxic zones, resulting in high species richness and abundance. Over the shelf, distinctions were sharp and the area under the influence of the plume presented a diverse assemblage occurring in large abundance, while outside the plume, the hydromedusa Liriope tetraphylla was dominant and occurred almost alone. Divergences in the oceanic province were less pronounced, but still expressive being mostly related to the abundance of dominant species. We concluded that Amazon River plume is a paramount physical feature that profoundly affects the dynamics of the mesoscale habitat structure in the Western Equatorial Atlantic Ocean and that such habitat structure is responsible for shaping planktonic cnidarian assemblages both in neritic and oceanic provinces.

Published
2023
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