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11 results on '"Tosetti, Maria"'

7. HHV-6 infects human aortic and heart microvascular endothelial cells, increasing their ability to secrete proinflammatory chemokines

Author

Caruso, Arnaldo, primary, Rotola, Antonella, additional, Comar, Manola, additional, Favilli, Flavia, additional, Galvan, Monica, additional, Tosetti, Maria, additional, Campello, Cesare, additional, Caselli, Elisabetta, additional, Alessandri, Giulio, additional, Grassi, Manuela, additional, Garrafa, Emirena, additional, Cassai, Enzo, additional, and Di Luca, Dario, additional

Published
2002
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9. Knowledge about epilepsy among teachers and epileptic patients

Author

Tosetti, Maria F. Valls, primary, Campos, Miriam A., additional, Bauer, Claudia R., additional, Araujo, Márcia M., additional, Pedrazolli, Sibelle, additional, Silva, Yara B., additional, Montovani, Cristina, additional, Haddad, Monica S., additional, Poetcher, A., additional, Cukiert, A., additional, and Marino Jr., R., additional

Published
1991
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10. Adult human heart microvascular endothelial cells are permissive for non-lytic infection by human cytomegalovirus.

Author

Ricotta, Doris, Alessandri, Giulio, Pollara, Caterina, Fiorentini, Simona, Favilli, Flavia, Tosetti, Maria, Mantovani, Alberto, Grassi, Manuela, Garrafa, Emirena, Dei Cas, Livio, Muneretto, Claudio, and Caruso, Arnaldo

Abstract

Objective: Human cytomegalovirus (CMV) infection has been linked to chronic heart disease. The mechanism of CMV dissemination to the heart remains unknown. CMV antigens and nucleic acid sequences have been detected in endothelial cells (ECs) in vivo, and ECs are fully permissive hosts to CMV replication in vitro. This report examines the characteristics of CMV replication in primary cultures of human heart microvascular ECs (HHMECs). Methods: Capillary ECs were isolated from heart tissue biopsies of six patients at the time of heart surgery. HHMECs were infected with CMV and viral antigens were detected by immunofluorescence assay using monoclonal antibodies as specific reagents. Cytokine and chemokine release in the supernatant of sham- and CMV-infected cells was quantitated by ELISA. Reverse transcriptase–polymerase chain reaction (RT–PCR) was used to analyse expression of mRNA for adhesion molecules. Results: CMV was found to productively infect HHMECs without cytolytic effects. Infected cultures released high levels of pro-inflammatory chemokines and enhanced their adhesion molecule expression. Conclusions: Our data provide new insights into the mechanism of CMV dissemination to the heart, signalling the need for further investigation of the pathogenetic role of this virus in cardiac disorders. [ABSTRACT FROM PUBLISHER]

Published
2001
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11. Comparative effects of different dihydropyridines on the expression of adhesion molecules induced by TNFα on endothelial cells

Author

Cominacini, Luciano, Pasini, Anna Fratta, Pastorino, Antonio M., Garbin, Ulisse, Davoli, Anna, Rigoni, Anna, Campagnola, Mario, Tosetti, Maria L., Rossato, Paolo, and Gaviraghi, Giovanni

Abstract

Lacidipine has already been demonstrated to reduce the expression of some adhesion molecules induced by pro-oxidant signals on endothelial cells. In order to verify if this effect is a peculiarity of this molecule, or belongs to other dihydropyridinic compounds (DHPs), the activity of lacidipine was compared with that of lercanidipine, amlodipine, nimodipine and nifedipine.

Published
1999

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