32 results on '"Toru, Tanizawa"'
Search Results
2. Anastomotic Recurrence of Sigmoid Colon Cancer over Five Years after Surgery
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Takahiro Yamauchi, Dai Shida, Toru Tanizawa, and Kentaro Inada
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Anastomotic recurrence ,Colon cancer ,Local recurrence ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
The incidence of anastomotic recurrence after curative resection of colorectal cancer is relatively low compared to that of other types of recurrence, such as hepatic, lung and local recurrence. However, almost all cases of anastomotic recurrence of colorectal cancer occur within 3 years after surgery. We experienced a rare case of anastomotic recurrence in whom colonoscopy revealed no signs of recurrence 3 years after surgery; however, anastomotic recurrence was detected over 5 years after surgery. A 60-year-old female with a history of surgery for cancer of the cecum in her forties underwent sigmoidectomy and right colectomy with D3 lymph node dissection for both stage IIA sigmoid colon cancer and stage IIA transverse colon cancer. Computed tomography and colonoscopy revealed no signs of recurrence 3 years after surgery; however, 5 years and 4 months after surgery, colonoscopy demonstrated surrounding flaring and swelling in the anastomotic area of the sigmoid colon, and a biopsy revealed an adenocarcinoma. Under the diagnosis of anastomotic recurrence over 5 years after surgery, lower anterior resection was performed. The patient has exhibited no other signs of recurrence in the 2 years since the last operation.
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- 2013
- Full Text
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3. Engrailed Homeobox 1 and Cytokeratin 19 Are Independent Diagnostic Markers of Eccrine Porocarcinoma and Distinguish It From Squamous Cell Carcinoma
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Shohei Tomii, Keiko Miura, Masahiro Warabi, Hiroshi Shintaku, Toru Tanizawa, Michio Tanaka, Jiro Kumagai, Shinya Ayabe, Yuko Kinowaki, Takumi Akashi, Keimei Murano, Ekapot Bhunchet, Takashi Ito, Takahiro Sekiya, Kurara Yamamoto, Susumu Kirimura, Noboru Ando, Urara Sakurai, Junichi Shiraishi, Kou Kayamori, Yuan Bae, Yoshinobu Eishi, Takeshi Namiki, and Tsunekazu Hishima
- Subjects
Adult ,Male ,Pathology ,medicine.medical_specialty ,Skin Neoplasms ,Engrailed homeobox 1 ,Tumor cells ,Eccrine porocarcinoma ,Diagnosis, Differential ,030207 dermatology & venereal diseases ,03 medical and health sciences ,Cytokeratin ,0302 clinical medicine ,Keratin ,Biomarkers, Tumor ,Humans ,Medicine ,Basal cell ,Aged ,Aged, 80 and over ,Homeodomain Proteins ,Keratin-19 ,chemistry.chemical_classification ,business.industry ,Diagnostic marker ,General Medicine ,Eccrine Porocarcinoma ,Middle Aged ,Sweat Gland Neoplasms ,chemistry ,030220 oncology & carcinogenesis ,Carcinoma, Squamous Cell ,Female ,business - Abstract
ObjectivesThe diagnostic utility of En1 in the histopathologic differentiation of eccrine porocarcinoma (EPC) from invasive squamous cell carcinoma (SCC) was investigated.MethodsExpression of En1 and CK19 in 16 cases of EPC was immunohistochemically examined and compared with that in 32 cases of SCC.ResultsIn all 16 EPCs, En1 was expressed in 3% to 100% of tumor cells. In 20 of the 32 SCCs, En1 was expressed in 3% to 90% of tumor cells. A total of 13 of the 16 EPCs and five of the 32 SCCs were judged as En1 positive, with a cutoff value of 25%. In addition, 11 of the 16 EPCs and four of the 32 SCCs were CK19 positive. The frequencies of En1- and CK19-positive cases were significantly higher in EPCs than in SCCs. In a logistic regression analysis for predicting EPC, En1 and CK19 were independent markers. When expression patterns of En1 and CK19 were combined, none of the 32 SCCs was both positive. In contrast, 15 of the 16 EPCs were positive for either En1 or CK19.ConclusionsA combination of En1 and CK19 expression can improve the accuracy of histologic diagnosis of EPC.
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- 2020
4. A Case of Endocrine Cell Carcinoma of the Sigmoid Colon Presented with Intramesenteric Penetration
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Tsuyoshi Maeshiro, Shunsaku Furuke, Kazuhiro Mori, Sachio Miyamoto, Atsushi Shimizu, and Toru Tanizawa
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Pathology ,medicine.medical_specialty ,medicine.anatomical_structure ,business.industry ,Carcinoma ,Medicine ,Sigmoid colon ,Enteroendocrine cell ,Penetration (firestop) ,business ,medicine.disease - Published
- 2020
5. An autopsy case of corticobasal syndrome with pure diffuse Lewy Body Disease
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Mutsufusa Watanabe, Keiko Ichinose, Hiroto Fujigasaki, Toshiki Uchihara, Saneyuki Mizutani, and Toru Tanizawa
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Lewy Body Disease ,Male ,Pathology ,medicine.medical_specialty ,Autopsy ,050105 experimental psychology ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Arts and Humanities (miscellaneous) ,Parkinsonian Disorders ,mental disorders ,medicine ,Humans ,0501 psychology and cognitive sciences ,Pathological ,Retrospective Studies ,Alpha-synuclein ,business.industry ,Parkinsonism ,05 social sciences ,Middle Aged ,medicine.disease ,chemistry ,Frontal lobe ,Neurology (clinical) ,Tauopathy ,Lewy body disease ,business ,030217 neurology & neurosurgery ,Frontotemporal dementia - Abstract
Corticobasal syndrome (CBS) is associated with diverse pathological substrates such as tau, prion protein, transactive response and, rarely, alpha synuclein. We report the case of a54-year-old man, who presented with asymmetric levodopa-poor-responsive parkinsonism, frontal lobe signs and behavioral changes. He was diagnosed with CBS, and postmortem analyses revealed Lewy body disease Braak stage VI without comorbid pathologies. Retrospectively, the clinical course of our patient and previous reports indicate that CBS plus mood changes and autonomic dysfunction, including reduced uptake of metaiodobenzylguanidine, are predictive factors of Lewy body pathology, even if the clinical picture is atypical.
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- 2021
6. A controlled inflammation and a regulatory immune system are associated with more favorable prognosis of progressive multifocal leukoencephalopathy
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Yoshiki Sekijima, Yukiko Shishido-Hara, Takanori Yokota, Hitoshi Aizawa, Yurie Nose, Nobuo Sanjo, Saneyuki Mizutani, and Toru Tanizawa
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Adult ,CD4-Positive T-Lymphocytes ,Male ,Pathology ,medicine.medical_specialty ,Lymphocyte ,H&E stain ,JC virus ,Inflammation ,CD8-Positive T-Lymphocytes ,medicine.disease_cause ,T-Lymphocytes, Regulatory ,03 medical and health sciences ,0302 clinical medicine ,Biopsy ,medicine ,Humans ,030212 general & internal medicine ,Aged ,medicine.diagnostic_test ,business.industry ,Progressive multifocal leukoencephalopathy ,Leukoencephalopathy, Progressive Multifocal ,JC Virus Infection ,Brain ,Middle Aged ,Prognosis ,medicine.disease ,JC Virus ,medicine.anatomical_structure ,Neurology ,Female ,Neurology (clinical) ,medicine.symptom ,business ,Viral load ,030217 neurology & neurosurgery - Abstract
In the present study, we analyzed the inflammatory profiles of brain tissues obtained from patients with progressive multifocal leukoencephalopathy (PML) due to John Cunningham (JC) virus infection to identify potential prognostic factors. The study included seven patients (two men, five women) who had been pathologically diagnosed with PML, and all of whom were HIV negative. Fixed brain samples were analyzed via hematoxylin and eosin (HE) staining and Kluver–Barrera (KB) staining. We then performed immunohistochemistry (IHC) specific to JC virus capsid proteins (VP1 and VP2/3) and lymphocyte surface markers (CD4, CD8, CD138, and PD-1). The mean age at onset was 53.4, while the mean duration until biopsy/autopsy was 4.7 months. Four patients were included in the good prognosis (GP) group, while three were included in the poor prognosis (PP) group. Pathological analysis revealed a significantly larger number of CD4-positive T-cell infiltrations (P = .029) in the GP group, along with a preserved CD4:CD8 ratio. Larger numbers of CD138-positive plasma cells were also observed in the GP group (P = .029) than in the PP group. Linear regression analyses revealed a significant association between the numbers of CD138-positive plasma cells and PD-1-positive cells (R2 = 0.80). Viral loads in the cerebrospinal fluid, a controlled inflammatory response mediated by CD4- and CD8-positive T cells, and plasma cells are associated with PML prognosis. Our findings further indicate that regulatory plasma cells may regulate inflammatory T-cell activity via a PD-1/PD-L1 immuno-checkpoint pathway, thereby protecting the uninfected brain from excessive immune-mediated damage during an active JC virus infection.
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- 2018
7. [A Case of Double Cancer of Intrahepatic Cholangiocarcinoma and Gastric Carcinoma with Difficult Diagnosis of the Primary Tumor with Peritoneal Metastasis]
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Hiroyuki, Kanomata, Yasuji, Seyama, Hiroki, Kudo, Toru, Tanizawa, Masahiro, Warabi, Masamichi, Takahashi, Yujiro, Matsuoka, Ikuo, Wada, Masayuki, Takegami, Yukio, Miyamoto, and Nobutaka, Umekita
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Cholangiocarcinoma ,Male ,Neoplasms, Multiple Primary ,Bile Duct Neoplasms ,Gastrectomy ,Stomach Neoplasms ,Liver Neoplasms ,Hepatectomy ,Humans ,Middle Aged ,Peritoneal Neoplasms - Abstract
Double cancer of intrahepatic cholangiocarcinoma and gastric cancer is rare. A 62-year-old man underwent gastrectomy for gastric cancer. The pathological findings were tub1tub2, m, ly0, v0, n0, Stage I A. Two years and a month later, a liver tumor(diameter of 3 cm)and a pelvic mass(diameter of 2.5 cm)were observed. Metastasis from gastric cancer was suspected and chemotherapy(SOX)was administered. However, after 5 courses, CT revealed worseningof the liver tumor (diameter of 12 cm)and pelvic mass(diameter of 3 cm). Intrahepatic cholangiocarcinoma and its peritoneal metastasis were also suspected. There was a limit to treatment with chemotherapy, and it was difficult to judge whether to target gastric cancer or intrahepatic cholangiocarcinoma for chemotherapy. In addition, the lesions were localized in the right lobe of the liver and the pelvis. Therefore, we decided to perform resection. As a second-stage operation, pelvic mass extraction and portal vein embolization were performed first. The pathological result of the pelvic mass assessment was mucinous carcinoma. Subsequently, expansive right hepatectomy was performed. The pathological findings were also suggestive of mucinous carcinoma, which was finally diagnosed as intrahepatic cholangiocarcinoma and peritoneal dissemination. Six months after the surgery, several recurrent nodules were observed in the pelvis and GEM plus CDDP was initiated. Currently, 1 year after surgery, there are no restrictions in the activities of daily life of the patient and he is treated on an outpatient basis.
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- 2018
8. Autopsy findings of a long-term hemodialysis case with sarcomatoid renal cell carcinoma
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Masayuki Sugimoto, Toru Tanizawa, Kanade Hagiwara, Masahiro Warabi, Yukio Honma, Yoshihiro Mukaiyama, Syunichi Oono, and Yasushi Kondou
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Pathology ,medicine.medical_specialty ,business.industry ,Sarcomatoid Renal Cell Carcinoma ,Medicine ,Autopsy ,Long term hemodialysis ,business - Published
- 2015
9. [A Case of Solitary Metastasis to the Small Intestine from Sigmoid Colon Cancer after Treatment of Seven Multiple Cancers]
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Keiichi, Nasu, Tsuyoshi, Maeshiro, Keiko, Yanai, Hanako, Fujita, Masaki, Machida, Takafumi, Moriyama, Takayoshi, Koseki, Hiroki, Kudo, Kentaro, Inada, Yukiko, Takahama, Yasuji, Seyama, Ikuo, Wada, Sachio, Miyamoto, Nobutaka, Umekita, and Toru, Tanizawa
- Subjects
Neoplasms, Multiple Primary ,Sigmoid Neoplasms ,Ileus ,Recurrence ,Intestinal Neoplasms ,Intestine, Small ,Humans ,Female ,Aged - Abstract
A 75-year-old woman who had undergone a Hartmann's operation for sigmoid colon cancer 2 years ago was hospitalized because she experienced small bowel obstruction several times. She had a treatment history of 6 other cancers, including 5 gastrointestinal tract cancers. However, the obstruction was relieved by conservative therapy each time. In September 2015, she was hospitalized for ileus. Abdominal computed tomography revealed that the lumen of intestine was partially dilated. Subsequently, a long tube was inserted, but the dilatation of the small intestine was not fully recovered. She was diagnosed with small intestinal obstruction due to adhesion, and she underwent an operation in October 2015. During the laparotomy, she was diagnosed with adhesion due to an intestinal tumor, and a partial intestinal resection, including the entire tumor, was performed. Because the tumor appearance and histological findings were very similar to those of sigmoid colon cancer, the tumor was diagnosed as a solitary metastasis of sigmoid colon cancer to the small intestine. Generally, peritoneal dissemination causes metastasis of colon cancer to the small intestine. However, this is a rare case because the lymphatic system or extra-wall invasion was the most likely cause of metastasis. Ileus repeating the improvement exacerbation, an examination must be performed while considering possible intestinal tumors, especially for a patient previously treated for multiple gastrointestinal cancers.
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- 2017
10. A Case of Long-term Survival of an Esophageal Mixed Type Carcinoma of Neuroendocrine Carcinoma Accompanied by Squamous Cell Carcinoma, Treated with Neoadjuvant and Adjuvant Chemotherapy
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Toru Tanizawa, Tsuguaki Kohno, Takeshi Toyozumi, Isamu Hoshino, Hisahiro Matsubara, and Yasunori Akutsu
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Oncology ,medicine.medical_specialty ,business.industry ,Adjuvant chemotherapy ,Gastroenterology ,Mixed type ,medicine.disease ,Internal medicine ,Long term survival ,Carcinoma ,medicine ,Surgery ,Neuroendocrine carcinoma ,Basal cell ,business - Published
- 2014
11. An adult case of intussusception due to rectal cancer
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Yujiro Matsuoka, Atsumi Tamura, Toru Tanizawa, Yukiko Takahama, Dai Shida, and Sachio Miyamoto
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medicine.medical_specialty ,Colorectal cancer ,business.industry ,General surgery ,Intussusception (medical disorder) ,medicine ,Adult case ,medicine.disease ,business - Published
- 2013
12. A case of toxic megacolon complicated by HIV infection in which surgical resection was highly effective
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Fukumi Nakamura, Toru Tanizawa, Sachio Miyamoto, Satoru Inoue, Dai Shida, and Mai Shimozono
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Surgical resection ,Toxic megacolon ,medicine.medical_specialty ,business.industry ,medicine ,Human immunodeficiency virus (HIV) ,medicine.disease ,medicine.disease_cause ,business ,Surgery - Published
- 2013
13. A case of anaphylactoid purpura assoicated with rectal cancer^|^mdash;report of a case^|^mdash;
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Sachio Miyamoto, Kyoko Tagawa, Toru Tanizawa, Dai Shida, Seiji Inoshita, and Kotaro Wakamatsu
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medicine.medical_specialty ,Purpura ,Colorectal cancer ,business.industry ,medicine ,medicine.symptom ,medicine.disease ,business ,Dermatology - Published
- 2013
14. A case of gastrointestinal stromal tumor of the small intestine with massive hemoperitoneum
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Toru Tanizawa, Sachio Miyamoto, Norihiko Nakazato, Dai Shida, and Kotaro Wakamatsu
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medicine.medical_specialty ,Pathology ,medicine.anatomical_structure ,business.industry ,General surgery ,medicine ,Hemoperitoneum ,Stromal tumor ,medicine.symptom ,business ,Small intestine - Published
- 2013
15. [Long Term Survival in a Case of Hilar Cholangiocarcinoma Treated with Chemotherapy and Surgery]
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Hiroyuki, Kanomata, Yasuji, Seyama, Keigo, Tani, Toru, Tanizawa, Masahiro, Warabi, Minekazu, Murayama, Toru, Asano, Masamichi, Takahashi, Yujiro, Matsuoka, Yukio, Miyamoto, and Nobutaka, Umekita
- Subjects
Male ,Time Factors ,Antineoplastic Agents ,Combined Modality Therapy ,Deoxycytidine ,Gemcitabine ,Cholangiocarcinoma ,Drug Combinations ,Oxonic Acid ,Pancreatectomy ,Treatment Outcome ,Bile Duct Neoplasms ,Hepatectomy ,Humans ,Aged ,Tegafur - Abstract
A 67-year-old man with elevated hepatobiliary enzymes was referred to our hospital for further examination. Computed tomography indicated hilar cholangiocarcinoma of Bismuth type Ⅳ and revealed invasion of the right hepatic artery and the left portal vein. We diagnosed locally advanced unresectable hilar cholangiocarcinoma, and performed 5 courses of chemotherapy with gemcitabine plus S-1. After chemotherapy, the tumor was significantly reduced in size and vascular invasions were alleviated, so we decided to perform surgical resection. An extended left hepatectomy with caudate lobe and extrahepatic bile duct resection was performed. Although the intraoperative pathological examination was positive for cancer at the hepatic margins, we did not perform further bile duct resection because of the difficulty. After the surgery, we administered adjuvant chemotherapy with gemcitabine for 5 courses. Another 8 courses of gemcitabine plus S-1 therapy were given because of elevation of CA19-9. The tumor marker levels normalized, and the patient is still alive without findings of recurrence 4 years after the first treatment. Multidisciplinary treatment with chemotherapy and surgery may suggest the possibility of increasing long term survival even for patients with locally advanced unresectable cholangiocarcinoma.
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- 2016
16. An extrarenal retroperitoneal angiomyolipoma located near the aortic bifurcation^|^mdash;report of a case^|^mdash;
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Toru Tanizawa, Yujiro Matsuoka, Satoru Inoue, Kyosuke Tsutsumi, Sachio Miyamoto, and Dai Shida
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medicine.medical_specialty ,Angiomyolipoma ,medicine.anatomical_structure ,business.industry ,medicine ,Radiology ,Aortic bifurcation ,medicine.disease ,business - Published
- 2012
17. Synchronous multiple colon cancers associated with japanese schistosomiasis^|^mdash;report of a case^|^mdash;
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Toru Tanizawa, Takuya Washino, Dai Shida, Satoru Inoue, Sachio Miyamoto, and Keiichi Nasu
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Oncology ,medicine.medical_specialty ,business.industry ,Internal medicine ,medicine ,Schistosomiasis ,medicine.disease ,business ,Gastroenterology - Published
- 2012
18. Selection of chemotherapy for glioblastoma expressing O6-methylguanine-DNA methyltransferase
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Shuichi Fujimoto, Natsuki Shinozaki, Naokatsu Saeki, Tomoo Matsutani, Takashi Oide, Toru Tanizawa, Yasuo Iwadate, Yukio Nakatani, and Yuzo Hasegawa
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Cancer Research ,Chemotherapy ,Temozolomide ,Methyltransferase ,Oncogene ,medicine.medical_treatment ,Cancer ,Articles ,General Medicine ,Biology ,medicine.disease ,Molecular medicine ,digestive system diseases ,Immunology and Microbiology (miscellaneous) ,medicine ,Cancer research ,Immunohistochemistry ,neoplasms ,Immunostaining ,medicine.drug - Abstract
The therapeutic benefit of nitrosoureas or temozolomide for glioblastoma is limited mainly by O(6)-methylguanine-DNA methyltransferase (MGMT) expression. The aim of this study was to evaluate the effectiveness of various anticancer drugs for MGMT-positive glioblastoma. Seventy-four glioblastoma patients were administered various anticancer drugs according to drug sensitivity testing. For the individualization, drug-induced apoptosis was quantified by flow cytometry in the primary culture of surgically resected tumor cells. The MGMT protein expression was analyzed by immunohistochemistry. The median survival of the patients receiving the individualized chemotherapy was 19.4 months (95% CI, 15.9-22.1). The patients with negative MGMT immunostaining had significantly longer survival than those with positive MGMT immunostaining [median survival, 22.3 months (95% CI, 17.6-27.0) vs. 15.1 months (95% CI, 13.4-16.8); p=0.0188]. For MGMT-positive tumors, the platinum agents and the taxanes were more frequently selected for administration than the other categories of anticancer agents. The patient survival period of MGMT-positive glioblastomas treated with the platinum agents or the taxanes [median survival, 20.1 months (95% CI, 18.0-22.7)] was significantly longer than that of MGMT-positive tumors treated with nitrosoureas (p=0.0026), and was equivalent to that of MGMT-negative glioblastomas (p=0.3047). These results suggest that the platinum agents and the taxanes offer the best probability to be effective against immunohistochemically MGMT-positive glioblastomas.
- Published
- 2010
19. A CASE OF MULTIPLE EARLY GASTRIC CARCINOMAS AT FIVE SITES ACCOMPANIED BY OLD SCHISTOSOMA JAPONICUM INFECTION
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Hisahiro Matsubara, Yorihiko Muto, Yoshihiro Nabeya, Hideki Hayashi, Yutaka Tanizawa, Takenori Ochiai, and Toru Tanizawa
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medicine.medical_specialty ,Schistosoma Japonicum Infection ,biology ,business.industry ,Internal medicine ,Schistosoma japonicum ,Medicine ,business ,biology.organism_classification ,Gastroenterology - Abstract
症例は70歳代後半の男性.検診で胃癌が発見され,術前の上部消化管内視鏡検査にて体上部2カ所と幽門部の計3カ所に多発する分化型早期胃癌の診断となり,胃全摘術を施行した.病理組織学的検索にて,術前診断し得なかった2病変を含む5カ所の多発早期胃癌を認めた.全て分化型の粘膜癌で転移はなくfT1N0H0P0CY0M0のfStageIaであった.さらに,粘膜下層から漿膜下層に日本住血吸虫卵が散在し,癌周囲で虫卵数が多い傾向を認めた.一方,背景胃粘膜に萎縮や腸上皮化生変化は少なかったが,免疫染色の結果から腫瘍胃粘膜は腸型形質を有していた.術後3年健在で,再発の兆候を認めない.全て分化型の同時性多発胃粘膜癌は極めてまれである.本症例は腸上皮化生を背景とせず,日本住血吸虫卵の存在が発癌に関与した腸型の多発早期胃癌の可能性が考えられる.稀少性とともに胃発癌機序解明の点からも貴重な症例と思われ,若干の文献的考察を加えて報告する.
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- 2010
20. angiosarcoma arising in the breast following breast-conserving surgery with radiation for breast carcinoma
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Hiroshi Fujimoto, Masahiro Sakakibara, Manabu Arai, Shigeharu Nakano, Toru Tanizawa, Naoto Tanabe, Takeshi Nagashima, Takashi Oide, Masaru Miyazaki, Rikiya Nakamura, and Masami Kadowaki
- Subjects
Selective Estrogen Receptor Modulators ,Oncology ,medicine.medical_specialty ,medicine.medical_treatment ,Hemangiosarcoma ,Breast Neoplasms ,Mastectomy, Segmental ,Breast cancer ,Internal medicine ,medicine ,Carcinoma ,Breast-conserving surgery ,Humans ,Pharmacology (medical) ,Radiology, Nuclear Medicine and imaging ,Angiosarcoma ,skin and connective tissue diseases ,Total Mastectomy ,Mastectomy ,business.industry ,Carcinoma, Ductal, Breast ,Neoplasms, Second Primary ,General Medicine ,Middle Aged ,medicine.disease ,Radiation therapy ,Tamoxifen ,Chemotherapy, Adjuvant ,Female ,Radiotherapy, Adjuvant ,Radiology ,business ,Breast carcinoma - Abstract
We report a case of angiosarcoma arising in the breast following breast-conserving surgery with radiation therapy for breast carcinoma. The patient, a 49-year-old postmenopausal woman, had undergone breast-conserving surgery for invasive ductal carcinoma of the left breast (pT2 pN0 M0 Stage IIA). Adjuvant radiotherapy (50 Gy with a booster dose to the tumor bed of 10 Gy) was then performed for the residual breast tissue and the patient was treated with hormone therapy (tamoxifen, 20 mg daily) for 5 years. She presented with skin erosion with bleeding 10 years after the initial operation. Incisional biopsy revealed angiosarcoma of the breast, and total mastectomy was subsequently performed. The patient was the treated with chemotherapy (weekly paclitaxel, 80 mg/m2 x cycles) and has remained well without evidence of local or distant recurrence.
- Published
- 2007
21. A Case of Polyarteritis Nodosa with Small Intestinal Perforation and Renal Aneurysm Rupture
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Akiko Hayakawa, Yoshihiro Okura, Yasuji Seyama, Toru Tanizawa, Jun Yamazaki, Tomoko Nakajima, Moko Zeniya, Seiji Inoshita, Keiichi Nasu, and Katsuhisa Satoh
- Subjects
medicine.medical_specialty ,Polyarteritis nodosa ,business.industry ,Renal aneurysm ,medicine ,General Medicine ,Small intestinal perforation ,medicine.disease ,business ,Surgery - Published
- 2013
22. Molecular Characterization of the Genomic Breakpoint Junction in the t(11;18) (q21;q21) Translocation of a Gastric MALT Lymphoma
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Shigeo Mori, Yumiko Sato, Toshikatsu Shibata, Ryuichi Kamiyama, Kiyoshi Saito, Yoshimitsu Akiyama, Yasuhito Yuasa, and Toru Tanizawa
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Lymphoma, B-Cell ,Oncogene Proteins, Fusion ,Transcription, Genetic ,Molecular Sequence Data ,Biophysics ,Chromosomal translocation ,Biology ,Biochemistry ,Translocation, Genetic ,Stomach Neoplasms ,hemic and lymphatic diseases ,medicine ,Humans ,Recombination signal sequences ,Cloning, Molecular ,Molecular Biology ,Genomic organization ,Expressed Sequence Tags ,Genetics ,Base Sequence ,Reverse Transcriptase Polymerase Chain Reaction ,Chromosomes, Human, Pair 11 ,V(D)J recombination ,Breakpoint ,Chromosome Mapping ,MALT lymphoma ,Lymphoma, B-Cell, Marginal Zone ,Cell Biology ,medicine.disease ,Molecular biology ,MALT1 ,genomic DNA ,Chromosomes, Human, Pair 18 - Abstract
The t(11;18) translocation, fusing the API2 and MALT1 genes, is one of the most frequent chromosomal translocations associated with mucosa-associated lymphoid tissue (MALT) lymphomas. The translocation breakpoints have been cloned and characterized at the mRNA sequence level. Although the genomic organization of the API2 gene has been described, hitherto the genomic sequence of MALT1 remains unknown. To gain some insight into the mechanism that generates this translocation, we cloned and sequenced an API2–MALT1 fused transcript as well as genomic DNA of the t(11;18) translocation from a MALT lymphoma. We localized the API2 breakpoint within intron 7. Nucleotide sequence analysis revealed that the genomic breakpoint junction possesses the consensus heptamers of immunoglobulin V(D)J recombination signal sequences, all the matches being completely present on the API2 allele and five of seven matches on the MALT1 allele. These data suggest that the translocation in the MALT lymphoma might have been mediated in part by an aberrant V(D)J recombination event.
- Published
- 2001
23. [Case report: a case of polyarteritis nodosa with small intestinal perforation and renal aneurysm rupture]
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Akiko, Hayakawa, Tomoko, Nakajima, Katsuhisa, Satoh, Jun, Yamazaki, Moko, Zeniya, Keiichi, Nasu, Yasuji, Seyama, Yoshihiro, Okura, Toru, Tanizawa, and Seiji, Inoshita
- Subjects
Adult ,Male ,Treatment Outcome ,Intestinal Perforation ,Intestine, Small ,Humans ,Aneurysm, Ruptured ,Tomography, X-Ray Computed ,Polyarteritis Nodosa - Published
- 2013
24. Endoscopic, histological and serologic findings of gastric hyperplastic polyps after eradication of Helicobacter pylori: comparison between responder and non-responder cases
- Author
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Jiro Kumagai, Nobuhiro Sato, Mariko Hojo, Toru Tanizawa, Daisuke Asaoka, Toshifumi Ohkusa, Ryuichi Ohkura, Takeshi Terai, and Hiroto Miwa
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Adult ,Male ,medicine.medical_specialty ,Pathology ,macromolecular substances ,Penicillins ,Gastroenterology ,Endoscopy, Gastrointestinal ,Statistics, Nonparametric ,Serology ,Helicobacter Infections ,Polyps ,Stomach Neoplasms ,Internal medicine ,Pepsinogen A ,Gastrins ,otorhinolaryngologic diseases ,medicine ,Humans ,Gastric Hyperplastic Polyp ,Aged ,Retrospective Studies ,Chi-Square Distribution ,Hyperplasia ,biology ,Helicobacter pylori ,business.industry ,Stomach ,Proton Pump Inhibitors ,Middle Aged ,biology.organism_classification ,digestive system diseases ,Anti-Bacterial Agents ,medicine.anatomical_structure ,Hyperplastic Polyp ,Immunoglobulin G ,Drug Therapy, Combination ,Female ,business - Abstract
Background: Evidence indicates that eradication of Helicobacter pylori leads to the disappearance of hyperplastic polyps in the stomach. However, there are some exceptions. We have compared endoscopic and serologic findings of responder and non-responder cases with hyperplastic polyps to try to identify the cause(s), other than H. pylori infection, of the formation or growth of gastric hyperplastic polyps. Methods: We retrospectively studied 33 patients whose hyperplastic polyps disappeared after eradication of H. pylori and 10 patients whose hyperplastic polyps did not disappear after eradication. The patients were examined both endoscopically and serologically before, 1–3 months after and 12–15 months after the eradication. Results: The responder and non-responder groups were similar with respect to age, sex, coexisting diseases, and histologic findings. The number and maximum size of polyps tended to be larger before treatment in the non-responder group than in the responder group. The serum gastrin level was higher in the non-responder group than in the responder group before, 1–3 months after and 12–15 months after the eradication (p = 0.0096, p > 0.2, p = 0.0014). On histologic examination, similar reductions in the degree of inflammatory cell infiltration in the gastric mucosa of the antrum and body were seen in both the responder and non-responder groups. In the non-responders, the size and numbers of the polyps regressed in 5 of the 10 patients. The score of glandular atrophy in the antrum and the serum gastrin levels in the non-regressed cases was higher than those in the regressed cases at 1–3 and 12–15 months after eradication. Conclusion: Persistent high gastrin levels were found in the non-responder cases with gastric hyperplastic polyps.
- Published
- 2003
25. An autopsy case of systemic air embolism during endoscopic treatment for a duodenal ulcer
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Misako Okabayashi, Yohei Furumoto, Toru Asano, Yoshimichi Chuganji, Yuji Miyamoto, Toru Tanizawa, Shinji Suzuki, Minekazu Murayama, Takao Horiuchi, Kazuhiko Fujiki, Masahiro Warabi, Syuji Hibiya, Nobutaka Umekita, Mamoru Watanabe, Naoko Sazaki, and Takashi Oshima
- Subjects
medicine.medical_specialty ,business.industry ,Mechanical Engineering ,General surgery ,Energy Engineering and Power Technology ,Autopsy case ,Management Science and Operations Research ,medicine.disease ,Air embolism ,Surgery ,Duodenal ulcer ,medicine ,business ,Endoscopic treatment - Published
- 2011
26. Lymphoepithelioma-like esophageal carcinoma with macroscopic reduction
- Author
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Masaya Uesato, Daisuke Horibe, Isamu Hoshino, Yukiko Ogura, Kentarou Murakami, Tuguaki Kono, Hisahiro Matsubara, Tetsurou Maruyama, Tooru Shiratori, Yoshihide Semba, Takashi Oide, Toru Tanizawa, Yasunori Akutsu, and Ryuma Urahama
- Subjects
Lymphoepithelioma-like carcinoma ,Pathology ,medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,Case Report ,Esophageal cancer ,medicine.disease ,medicine.anatomical_structure ,Esophagectomy ,Carcinoma ,Adjuvant therapy ,Medicine ,Esophagus ,business ,Lymph node ,Lymphoepithelioma - Abstract
Esophageal lymphoepithelioma-like carcinoma (LELC) is extremely rare. We report the first case of esophageal LELC showing macroscopic reduction. A 67-year-old male presented with dysphagia and, by endoscopic examination, was found to have a significantly raised tumor of 10 mm in diameter in the thoracic esophagus. The biopsied material showed esophageal cancer. We performed endoscopic submucosal dissection. However, the tumor became flattened, similar to a scar, in only 2 mo. Histologically, the carcinoma cells had infiltrated the submucosal layer. Prominent infiltration of T lymphoid cells that stained positive for CD8 was observed around the carcinoma cells. Therefore, this lesion was considered to be an LELC with poorly differentiated squamous cells. Because the margin was positive, an esophagectomy was performed. Carcinoma cells were detected in the neck in one lymph node. The staging was T1N0M1b. However, the patient has been well, without adjuvant therapy or recurrence, for more than 5 years.
- Published
- 2014
27. Improvement in atrophic gastritis and intestinal metaplasia in patients in whom Helicobacter pylori was eradicated
- Author
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Tetsuji Yokoyama, Jiro Kumagai, Toshifumi Ohkusa, Mamoru Watanabe, Ichizen Takashimizu, Toru Tanizawa, Yoshinobu Eishi, and Kazuhiko Fujiki
- Subjects
Adult ,Gastritis, Atrophic ,Male ,medicine.medical_specialty ,Atrophic gastritis ,Biopsy ,Gastroenterology ,2-Pyridinylmethylsulfinylbenzimidazoles ,Endoscopy, Gastrointestinal ,Helicobacter Infections ,Atrophy ,Metaplasia ,Internal medicine ,Internal Medicine ,medicine ,Humans ,Lansoprazole ,Single-Blind Method ,Prospective Studies ,Dyspepsia ,Antrum ,Antibacterial agent ,Aged ,biology ,business.industry ,Intestinal metaplasia ,Proton Pump Inhibitors ,General Medicine ,Helicobacter pylori ,Middle Aged ,biology.organism_classification ,medicine.disease ,Anti-Ulcer Agents ,Anti-Bacterial Agents ,Intestines ,Drug Therapy, Combination ,Female ,medicine.symptom ,Gastritis ,business ,Precancerous Conditions ,Omeprazole ,Follow-Up Studies - Abstract
Background: Glandular atrophy and intestinal metaplasia are precancerous lesions; whether Helicobacter pylori eradication affects these lesions Is controversial. Objective: To determine whether H. pylori eradication is associated with improvement in glandular atrophy and intestinal metaplasia after at least 1 year. Design: Single-blind, uncontrolled prospective trial. Setting: Academic gastroenterology clinic in Japan. Patients: 163 consecutive patients with dyspepsia and H. pylori infection. Intervention: One-week course of a proton-pump inhibitor and antibiotic therapy. Measurements: Endoscopic examination with antral and corporal biopsy was done before treatment and at 1 to 3 and 12 to 15 months after treatment Gastritis, atrophy, and metaplasia were graded according to the updated Sydney System. Results: In the 115 patients in whom H. pylori was eradicated, inflammation and mean neutrophil activity had decreased by 1 to 3 months, and both glandular atrophy in the corpus and intestinal metaplasia in the antrum had decreased by 12 to 15 months. Glandular atrophy in the corpus improved in 34 (89%) of 38 patients with atrophy before treatment, and intestinal metaplasia in the antrum improved in 28 (61%) of 46 patients who had metaplasia at baseline. In the 48 patients in whom eradication was unsuccessful, no significant histologic changes were observed. Conclusion: In the year after successful H. pylori eradication, precancerous lesions improved in most patients.
- Published
- 2001
28. Endoscopic and histological comparison of nonulcer dyspepsia with and without Helicobacter pylori infection evaluated by the modified Sydney system
- Author
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Jiro Kumagai, Toshifumi Ohkusa, Kazuhiko Fujiki, Ichizen Takashimizu, Yoshinobu Eishi, and Toru Tanizawa
- Subjects
Male ,medicine.medical_specialty ,Helicobacter pylori infection ,Neutrophils ,Spirillaceae ,Biopsy ,Biological effect ,Gastroenterology ,Helicobacter Infections ,Diagnosis, Differential ,Internal medicine ,medicine ,Odds Ratio ,Humans ,Endoscopy, Digestive System ,Dyspepsia ,Retrospective Studies ,Metaplasia ,Hepatology ,medicine.diagnostic_test ,biology ,Helicobacter pylori ,business.industry ,digestive, oral, and skin physiology ,Reproducibility of Results ,Hypertrophy ,Middle Aged ,biology.organism_classification ,Prognosis ,digestive system diseases ,Gastric Mucosa ,Gastritis ,Female ,medicine.symptom ,Atrophy ,business - Abstract
Our aim was to identify endoscopic features associated with Helicobacter pylori (H. pylori) infection in patients with nonulcer dyspepsia.A total of 50 infected patients with nonulcer dyspepsia who underwent endoscopy with antral and corporal biopsies and 50 patients matched for age and sex but with nonulcer dyspepsia without H. pylori were reviewed retrospectively by three endoscopists blinded to the H. pylori status and the patient's history. The endoscopic findings of gastritis, classified by a modification of the Sydney system as present or absent, were evaluated, and the histological severity was graded by the updated Sydney system.For endoscopic features, the odds ratio was 53.1 (95% confidence interval, 6.8-414.9) for edema, 18.8 (5.8-60.5) for erythema with reddish streaks excluded, 0.0275 (0.0002-0.477) for reddish streaks, 17.4 (0.97-313.7) for friability, 14.2 (5.1-40.0) for exudate, 17.2 (2.2-137.6) for flat erosions, 2.54 (0.81-7.94) for raised erosions, 40.1 (2.3-694.5) for rugal hypertrophy, 19.1 (2.4-151.6) for rugal atrophy, 96.2 (23.4-395.9) for a vascular pattern, 0.125 (0.010-1.06) for bleeding spots, and 21.0 (2.6-166.5) for nodularity. The histological severity of inflammation, neutrophil activity, and atrophy in the antrum and corpus and of metaplasia in the antrum was greater in the infected patients than in the noninfected patients.Endoscopic features associated with H. pylori were a vascular pattern, edema, rugal hypertrophy, nodularity, rugal atrophy, erythema with reddish streaks excluded, flat erosions, and exudate. These endoscopic features were associated with the histological findings of inflammation, neutrophil activity, atrophy, and metaplasia.
- Published
- 2000
29. Disappearance of hyperplastic polyps in the stomach after eradication of Helicobacter pylori. A randomized, clinical trial
- Author
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Jiro Kumagai, Kengo Shimoi, Toshifumi Ohkusa, Toshiaki Sakurazawa, Ichizen Takashimizu, Koichiro Ariake, Shinji Suzuki, Takao Horiuchi, Toru Tanizawa, Kazuhiko Fujiki, and Kenichi Ishii
- Subjects
Adult ,Male ,medicine.medical_specialty ,Lansoprazole ,Penicillins ,Gastroenterology ,2-Pyridinylmethylsulfinylbenzimidazoles ,Statistics, Nonparametric ,Helicobacter Infections ,Polyps ,Stomach Neoplasms ,Clarithromycin ,Internal medicine ,Gastrins ,Internal Medicine ,medicine ,Outpatient clinic ,Humans ,Single-Blind Method ,Gastric Hyperplastic Polyp ,Omeprazole ,Aged ,Hyperplasia ,biology ,Helicobacter pylori ,business.industry ,Amoxicillin ,Proton Pump Inhibitors ,General Medicine ,Middle Aged ,biology.organism_classification ,digestive system diseases ,Anti-Bacterial Agents ,Hyperplastic Polyp ,Gastric Polyp ,Immunoglobulin G ,Abietanes ,Drug Therapy, Combination ,Female ,Diterpenes ,business ,medicine.drug - Abstract
Background: Helicobacter pylori infection is common in patients with hyperplastic gastric polyps. Objective: To study the effect of eradication of H. pylor, on the clinical course of patients with hyperplastic gastric polyps. Design: Single-blind, randomized, controlled trial. Setting: University-based gastroenterology outpatient clinic. Patients: 35 patients with H. pylori infection and hyperplastic gastric polyps at least 3 mm in diameter. Intervention: Patients were randomly assigned to a treatment group (n = 17), which received a proton-pump inhibitor (omeprazole or lansoprazole), amoxicillin, and either clarithromycin or ecabet sodium, or to a control group (n = 18), which received no treatment. Measurements: Patients underwent endoscopy before enrollment and 12 to 15 months after the end of treatment. Serum gastrin levels and titers of IgG to H. pylori were measured. Results: In the treatment group, the polyps had disappeared by 3 to 15 months (average, 7.1 ± 1.2 months) after the end of treatment in 12 of all 17 patients (71%) and in 12 of the 15 patients (80%) in whom H. pylori was eradicated. However, 12 to 15 months after the start of the study, no change in polyps or H. pylori status was seen in any controls (P < 0.001). Histologic findings of inflammation and activity, serum gastrin levels, and titers of IgG to H. pylori showed significant regression in the treatment group compared with the control group (P < 0.01). Conclusions: Most hyperplastic polyps disappeared after eradication of H. pylori. Thus, eradication should be attempted before endoscopic removal is done in patients with hyperplastic gastric polyps and H. pylori infection.
- Published
- 1998
30. Disappearance of gastric hyperplastic polyps after eradication of Helicobacter pylori: Comparison between responder and non-responder cases
- Author
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Mariko Hojo, Takeshi Terai, Daisuke Asaoka, Nobuhiro Sato, Ryuichi Ohkura, Hiroto Miwa, Toru Tanizawa, Toshifumi Ohkusa, and Jiro Kumagai
- Subjects
medicine.medical_specialty ,Hepatology ,biology ,business.industry ,Internal medicine ,Gastroenterology ,medicine ,Gastric Hyperplastic Polyp ,Helicobacter pylori ,business ,biology.organism_classification - Published
- 2003
31. Improvement in infestinal metaplasia and atrophic gastritis in patients from whom Helicobacter pylori was eradicated
- Author
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Yoshinobu Eishi, Jiro Kumagai, Mamoru Watanabe, Kazuhiko Fujiki, Ichizen Takashimizu, Toru Tanizawa, Toshufumi Ohkusa, and Tetsuji Yokoyama
- Subjects
medicine.medical_specialty ,Hepatology ,biology ,business.industry ,Atrophic gastritis ,Gastroenterology ,Helicobacter pylori ,medicine.disease ,biology.organism_classification ,Internal medicine ,Metaplasia ,Medicine ,In patient ,medicine.symptom ,business - Published
- 2001
32. Regression of atrophic gastritis and intestinal metaplasia in patients from whom Helicobacter pylori was eradicated monitored prospectively for at least one year
- Author
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Toru Tanizawa, Yoshinobu Eishi, Toshifumi Ohkusa, Kazuhiko Fujiki, Ichizen Takashimizu, and Jiro Kumagai
- Subjects
medicine.medical_specialty ,Hepatology ,biology ,Atrophic gastritis ,business.industry ,Gastroenterology ,Intestinal metaplasia ,Helicobacter pylori ,biology.organism_classification ,medicine.disease ,Internal medicine ,medicine ,In patient ,business - Published
- 2000
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