435 results on '"Tortorella, Carla"'
Search Results
2. Unusual CLIPPERS presentation with a predominant spinal cord involvement: case report and review of the literature
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Cruciani, Alessandro, Motolese, Francesco, Tortorella, Carla, Haggiag, Shalom, Santoro, Francesca, Pozzilli, Valeria, Rossi, Mariagrazia, Pilato, Fabio, Gasperini, Claudio, Di Lazzaro, Vincenzo, and Capone, Fioravante
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- 2024
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3. Concurrent management of multiple sclerosis and natalizumab-induced hepatitis with ofatumumab: a case report
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Haggiag, Shalom, Giannelli, Valerio, Prosperini, Luca, Cruciani, Alessandro, Baiocchini, Andrea, Ruggieri, Serena, Pellicelli, Adriano, Gasperini, Claudio, and Tortorella, Carla
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- 2024
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4. Moving towards a new era for the treatment of neuromyelitis optica spectrum disorders
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Preziosa, Paolo, Amato, Maria Pia, Battistini, Luca, Capobianco, Marco, Centonze, Diego, Cocco, Eleonora, Conte, Antonella, Gasperini, Claudio, Gastaldi, Matteo, Tortorella, Carla, and Filippi, Massimo
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- 2024
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5. Correction to: Moving towards a new era for the treatment of neuromyelitis optica spectrum disorders
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Preziosa, Paolo, Amato, Maria Pia, Battistini, Luca, Capobianco, Marco, Centonze, Diego, Cocco, Eleonora, Conte, Antonella, Gasperini, Claudio, Gastaldi, Matteo, Tortorella, Carla, and Filippi, Massimo
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- 2024
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6. Evaluation of drivers of treatment switch in relapsing multiple sclerosis: a study from the Italian MS Registry
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Iaffaldano, Pietro, Lucisano, Giuseppe, Guerra, Tommaso, Patti, Francesco, Cocco, Eleonora, De Luca, Giovanna, Brescia Morra, Vincenzo, Pozzilli, Carlo, Zaffaroni, Mauro, Ferraro, Diana, Gasperini, Claudio, Salemi, Giuseppe, Bergamaschi, Roberto, Lus, Giacomo, Inglese, Matilde, Romano, Silvia, Bellantonio, Paolo, Di Monte, Elisabetta, Maniscalco, Giorgia Teresa, Conte, Antonella, Lugaresi, Alessandra, Vianello, Marika, Torri Clerici, Valentina Liliana Adriana, Di Sapio, Alessia, Pesci, Ilaria, Granella, Franco, Totaro, Rocco, Marfia, Girolama Alessandra, Danni, Maura Chiara, Cavalla, Paola, Valentino, Paola, Aguglia, Umberto, Montepietra, Sara, Ferraro, Elisabetta, Protti, Alessandra, Spitaleri, Daniele, Avolio, Carlo, De Riz, Milena, Maimone, Davide, Cavaletti, Guido, Gazzola, Paola, Tedeschi, Gioacchino, Sessa, Maria, Rovaris, Marco, Di Palma, Franco, Gatto, Maurizia, Cargnelutti, Daniela, De Robertis̄, Francesca, Logullo, Francesco Ottavio, Rini, Augusto, Meucci, Giuseppe, Ardito, Bonaventura, Banfi, Paola, Nasuelli, Davide, Paolicelli, Damiano, Rocca, Maria Assunta, Portaccio, Emilio, Chisari, Clara Grazia, Fenu, Giuseppe, Onofrj, Marco, Carotenuto, Antonio, Ruggieri, Serena, Tortorella, Carla, Ragonese, Paolo, Nica, Mihaela, Amato, Maria Pia, Filippi, Massimo, and Trojano, Maria
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- 2024
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7. Correction to: Concurrent management of multiple sclerosis and natalizumab‑induced hepatitis with ofatumumab: a case report
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Haggiag, Shalom, Giannelli, Valerio, Prosperini, Luca, Cruciani, Alessandro, Baiocchini, Andrea, Ruggieri, Serena, Pellicelli, Adriano, Gasperini, Claudio, and Tortorella, Carla
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- 2024
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8. SARS-CoV-2 vaccination and multiple sclerosis: a large multicentric study on relapse risk after the third booster dose
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Di Filippo, Massimiliano, Ferraro, Diana, Ragonese, Paolo, Prosperini, Luca, Maniscalco, Giorgia Teresa, Gallo, Antonio, Cavalla, Paola, Lorefice, Lorena, Nociti, Viviana, Di Sabatino, Elena, Clerico, Marinella, Guaschino, Clara, Radaelli, Marta, Fantozzi, Roberta, Buttari, Fabio, Laroni, Alice, Gajofatto, Alberto, Calabrese, Massimiliano, Malucchi, Simona, Paolicelli, Damiano, De Luca, Giovanna, Tomassini, Valentina, Lanzillo, Roberta, Moccia, Marcello, Solaro, Claudio, Cocco, Eleonora, Gasperini, Claudio, and Tortorella, Carla
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- 2024
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9. Stopping Disease-Modifying Treatments in Multiple Sclerosis: A Systematic Review and Meta-Analysis of Real-World Studies
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Prosperini, Luca, Haggiag, Shalom, Ruggieri, Serena, Tortorella, Carla, and Gasperini, Claudio
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- 2023
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10. Dimethyl Fumarate or Teriflunomide for Relapsing–Remitting Multiple Sclerosis: A Meta-analysis of Post-marketing Studies
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Prosperini, Luca, Haggiag, Shalom, Ruggieri, Serena, Tortorella, Carla, and Gasperini, Claudio
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- 2023
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11. Neurophysiological methods for assessing and treating cognitive impairment in multiple sclerosis: A scoping review of the literature
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Cruciani, Alessandro, Santoro, Francesca, Pozzilli, Valeria, Todisco, Antonio, Pilato, Fabio, Motolese, Francesco, Celani, Licia Maria, Pantuliano, Maria Chiara, Tortorella, Carla, Haggiag, Shalom, Ruggieri, Serena, Gasperini, Claudio, Di Lazzaro, Vincenzo, and Capone, Fioravante
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- 2024
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12. Disease-modifying therapies in managing disability worsening in paediatric-onset multiple sclerosis: a longitudinal analysis of global and national registries
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Horakova, Dana, Prat, Alexandre, Girard, Marc, Duquette, Pierre, Boz, Cavit, Pozzilli, Carlo, Cocco, Eleonora, Gallo, Paolo, Yamout, Bassem, Khoury, Samia J., Lugaresi, Alessandra, Onofrj, Marco, Lus, Giacomo, Clerici, Valentina Torri, Maniscalco, Giorgia Teresa, Romano, Silvia, Tortorella, Carla, Valentino, Paola, Rovaris, Marco, Shaygannejad, Vahid, Ferraro, Diana, Vianello, Marika, Grammond, Pierre, Bergamaschi, Roberto, Gallo, Antonio, Cavalla, Paola, Sa, Maria Jose, Lechner-Scott, Jeannette, Pesci, Ilaria, Buzzard, Katherine, Gouider, Riadh, Mrabet, Saloua, Aguglia, Umberto, Conte, Antonella, Avolio, Carlo, Bellantonio, Paolo, John, Nevin, Cartechini, Elisabetta, De Robertis, Francesca, Ferraro, Elisabetta, Weinstock-Guttman, Bianca, Barcella, Valeria, Van der Walt, Anneke, Butzkueven, Helmut, Coniglio, Maria Gabriella, Granella, Franco, Kuhle, Jens, Marfia, Girolama Alessandra, Laureys, Guy, Van Hijfte, Liesbeth, Maimone, Davide, Gazzola, Paola, Blanco, Yolanda, Turkoglu, Recai, Montepietra, Sara, Spitaleri, Daniele, van Pesch, Vincent, Gerlach, Oliver, Prevost, Julie, Ampapa, Radek, Soysal, Aysun, Altintas, Ayse, Rini, Augusto, Solaro, Claudio, Protti, Alessandra, Foschi, Matteo, Surcinelli, Andrea, Gatto, Maurizia, Mascoli, Nerina, De Riz, Milena, Realmuto, Sabrina, Rossi, Patrizia, Totaro, Rocco, Barnett, Michael, Oh, Jiwon, Nasuelli, Davide, Ramo-Tello, Cristina, Sanchez-Menoyo, Jose Luis, Al-Harbi, Talal, Fioretti, Cristina, Bucello, Sebastiano, Cargnelutti, Daniela, Vukusic, Sandra, Sharmin, Sifat, Roos, Izanne, Malpas, Charles B, Iaffaldano, Pietro, Simone, Marta, Filippi, Massimo, Kubala Havrdova, Eva, Ozakbas, Serkan, Brescia Morra, Vincenzo, Alroughani, Raed, Zaffaroni, Mauro, Patti, Francesco, Eichau, Sara, Salemi, Giuseppe, Di Sapio, Alessia, Inglese, Matilde, Portaccio, Emilio, Trojano, Maria, Amato, Maria Pia, and Kalincik, Tomas
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- 2024
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13. Treatment modifiers across different regimens of natalizumab treatment in MS: An Italian real-world experience
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Ruggieri, Serena, Ianniello, Antonio, Copetti, Massimiliano, Altieri, Marta, Buscarinu, Maria Chiara, Centonze, Diego, Cortese, Antonio, De Giglio, Laura, Fantozzi, Roberta, Gasperini, Claudio, Grimaldi, Luigi M.E., Landi, Doriana, Marfia, Girolama A., Mirabella, Massimiliano, Nistri, Riccardo, Nociti, Viviana, Oddo, Oscar, Romano, Silvia, Salemi, Giuseppe, Tortorella, Carla, Pozzilli, Carlo, and Petracca, Maria
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- 2024
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14. Disease‐Modifying Therapies and Coronavirus Disease 2019 Severity in Multiple Sclerosis
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Sormani, Maria P, De Rossi, Nicola, Schiavetti, Irene, Carmisciano, Luca, Cordioli, Cinzia, Moiola, Lucia, Radaelli, Marta, Immovilli, Paolo, Capobianco, Marco, Trojano, Maria, Zaratin, Paola, Tedeschi, Gioacchino, Comi, Giancarlo, Battaglia, Mario A, Patti, Francesco, Salvetti, Marco, Nozzolillo, Agostino, Bellacosa, Alessandra, Protti, Alessandra, Di Sapio, Alessia, Signori, Alessio, Petrone, Alfredo, Bisecco, Alvino, Iovino, Aniello, Dutto, Anna, Repice, Anna Maria, Conte, Antonella, Bertolotto, Antonio, Bosco, Antonio, Gallo, Antonio, Zito, Antonio, Sartori, Arianna, Giometto, Bruno, Tortorella, Carla, Antozzi, Carlo, Pozzilli, Carlo, Mancinelli, Chiara Rosa, Zanetta, Chiara, Cordano, Christian, Scandellari, Cinzia, Guaschino, Clara, Gasperini, Claudio, Solaro, Claudio, Fioretti, Cristina, Bezzini, Daiana, Marastoni, Damiano, Paolicelli, Damiano, Vecchio, Domizia, Landi, Doriana, Bucciantini, Elisabetta, Pedrazzoli, Elisabetta, Signoriello, Elisabetta, Sbragia, Elvira, Susani, Emanuela Laura, Curti, Erica, Milano, Eva, Marinelli, Fabiana, Camilli, Federico, Boneschi, Filippo Martinelli, Govone, Flora, Bovis, Francesca, Calabria, Francesca, Caleri, Francesca, Rinaldi, Francesca, Vitetta, Francesca, Corea, Francesco, Crescenzo, Francesco, Teatini, Francesco, Tabiadon, Giulietta, Granella, Franco, Boffa, Giacomo, Lus, Giacomo, Brichetto, Giampaolo, Maniscalco, Giorgia Teresa, Borriello, Giovanna, De Luca, Giovanna, Konrad, Giovanna, Vaula, Giovanna, Marfia, Girolama Alessandra, Mallucci, Giulia, Liberatore, Giuseppe, Salemi, Giuseppe, Miele, Giuseppina, Sibilia, Grazia, Pesci, Ilaria, Brambilla, Laura, Lopiano, Leonardo, Sinisi, Leonardo, Pasquali, Livia, Saraceno, Lorenzo, Chiveri, Luca, Mancinelli, Luca, and Grimaldi, Luigi ME
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Pneumonia & Influenza ,Neurodegenerative ,Clinical Research ,Autoimmune Disease ,Brain Disorders ,Lung ,Multiple Sclerosis ,Pneumonia ,Neurosciences ,Neurological ,Good Health and Well Being ,Adolescent ,Adult ,Aged ,Aged ,80 and over ,Antibodies ,Monoclonal ,Humanized ,COVID-19 ,Dimethyl Fumarate ,Female ,Fingolimod Hydrochloride ,Hospitalization ,Humans ,Immunologic Factors ,Immunosuppressive Agents ,Intensive Care Units ,Interferons ,Male ,Middle Aged ,Mortality ,Natalizumab ,SARS-CoV-2 ,Severity of Illness Index ,Young Adult ,Musc-19 Study Group ,Clinical Sciences ,Neurology & Neurosurgery - Abstract
ObjectiveThis study was undertaken to assess the impact of immunosuppressive and immunomodulatory therapies on the severity of coronavirus disease 2019 (COVID-19) in people with multiple sclerosis (PwMS).MethodsWe retrospectively collected data of PwMS with suspected or confirmed COVID-19. All the patients had complete follow-up to death or recovery. Severe COVID-19 was defined by a 3-level variable: mild disease not requiring hospitalization versus pneumonia or hospitalization versus intensive care unit (ICU) admission or death. We evaluated baseline characteristics and MS therapies associated with severe COVID-19 by multivariate and propensity score (PS)-weighted ordinal logistic models. Sensitivity analyses were run to confirm the results.ResultsOf 844 PwMS with suspected (n = 565) or confirmed (n = 279) COVID-19, 13 (1.54%) died; 11 of them were in a progressive MS phase, and 8 were without any therapy. Thirty-eight (4.5%) were admitted to an ICU; 99 (11.7%) had radiologically documented pneumonia; 96 (11.4%) were hospitalized. After adjusting for region, age, sex, progressive MS course, Expanded Disability Status Scale, disease duration, body mass index, comorbidities, and recent methylprednisolone use, therapy with an anti-CD20 agent (ocrelizumab or rituximab) was significantly associated (odds ratio [OR] = 2.37, 95% confidence interval [CI] = 1.18-4.74, p = 0.015) with increased risk of severe COVID-19. Recent use (
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- 2021
15. Determinants of COVID-19-related lethality in multiple sclerosis: a meta-regression of observational studies
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Prosperini, Luca, Tortorella, Carla, Haggiag, Shalom, Ruggieri, Serena, Galgani, Simonetta, and Gasperini, Claudio
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- 2022
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16. The impact of PM2.5, PM10 and NO2 on Covid-19 severity in a sample of patients with multiple sclerosis: A case-control study
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Gianmarco, Abbadessa, Umberto, Aguglia, Lia, Allegorico, Maria, Allegri Rossi Beatrice, Anastasia, Alteno, Pia, Amato Maria, Pietro, Annovazzi, Carlo, Antozzi, Lucia, Appendino, Sebastiano, Arena, Viola, Baione, Roberto, Balgera, Valeria, Barcella, Damiano, Baroncini, Caterina, Barrilà, Mario A, Battaglia, Alessandra, Bellacosa, Gianmarco, Bellucci, Roberto, Bergamaschi, Valeria, Bergamaschi, Daiana, Bezzini, Beatrice, Biolzi, Alvino, Bisecco, Simona, Bonavita, Giovanna, Borriello, Chiara, Bosa, Antonio, Bosco, Francesca, Bovis, Marco, Bozzali, Laura, Brambilla, Vincenzo, Brescia Morra, Giampaolo, Brichetto, Maria, Buccafusca, Elisabetta, Bucciantini, Sebastiano, Bucello, Chiara, Buscarinu Maria, Paola, Cabboi Maria, Massimiliano, Calabrese, Francesca, Calabria, Francesca, Caleri, Federico, Camilli, Maria, Caniatti Luisa, Roberto, Cantello, Marco, Capobianco, Ruggero, Capra, Rocco, Capuano, Luca, Carmisciano, Patrizia, Carta, Paola, Cavalla, Grazia, Celani Maria, Maria, Cellerino, Raffaella, Cerqua, Clara, Chisari, Raffaella, Clerici, Marinella, Clerico, Eleonora, Cocco, Gaia, Cola, Giancarlo, Comi, Paolo, Confalonieri, Antonella, Conte, Zaffira, Conti Marta, Christian, Cordano, Susanna, Cordera, Cinzia, Cordioli, Francesco, Corea, Claudio, Correale, Salvatore, Cottone, Francesco, Crescenzo, Erica, Curti, Alessandro, d'Ambrosio, Emanuele, D'Amico, Chiara, Danni Maura, Alessia, d'Arma, Vincenzo, Dattola, Stefano, de Biase, Giovanna, De Luca, Federica, De Mercanti Stefania, Paolo, De Mitri, Nicola, De Rossi, Nicola, De Stefano, Maria, Della Cava Fabio, Marco, Della Cava, Sonia, Di Lemme, Mario, di Napoli, Alessia, Di Sapio, Renato, Docimo, Anna, Dutto, Luana, Evangelista, Salvatore, Fanara, Roberta, Fantozzi, Diana, Ferraro, Teresa, Ferrò Maria, Massimo, Filippi, Cristina, Fioretti, Mario, Fratta, Jessica, Frau, Marzia, Fronza, Roberto, Furlan, Alberto, Gajofatto, Antonio, Gallo, Paolo, Gallo, Claudio, Gasperini, Anna, Ghazaryan, Bruno, Giometto, Francesca, Gobbin, Flora, Govone, Franco, Granella, Erica, Grange, Grazia, Grasso Maria, Luigi ME, Grimaldi, Angelica, Guareschi, Clara, Guaschino, Simone, Guerrieri, Donata, Guidetti, Barbara, Juergenson Ina, Pietro, Iaffaldano, Antonio, Ianniello, Luigi, Iasevoli, Paolo, Immovilli, Daniele, Imperiale, Teresa, Infante Maria, Matilde, Inglese, Rosa, Iodice, Aniello, Iovino, Giovanna, Konrad, Doriana, Landi, Roberta, Lanzillo, Caterina, Lapucci, Luigi, Lavorgna, Rita, L'Episcopo Maria, Serena, Leva, Giuseppe, Liberatore, Marianna, Lo Re, Marco, Longoni, Leonardo, Lopiano, Lorena, Lorefice, Matteo, Lucchini, Giacomo, Lus, Davide, Maimone, Maria, Malentacchi, Giulia, Mallucci, Simona, Malucchi, Rosa, Mancinelli Chiara, Luca, Mancinelli, Paolo, Manganotti, Teresa, Maniscalco Giorgia, Vittorio, Mantero, Sabrina, Marangoni, Damiano, Marastoni, Alessandra, Marfia Girolama, Fabiana, Marinelli, Alessandro, Marti, Filippo, Martinelli Boneschi, Federco, Masserano Zoli, Francesca, Matta, Laura, Mendozzi, Giuseppe, Meucci, Silvia, Miante, Giuseppina, Miele, Eva, Milano, Massimiliano, Mirabella, Rosanna, Missione, Marcello, Moccia, Lucia, Moiola, Sara, Montepietra, Margherita, MontiBragadin, Federico, Montini, Roberta, Motta, Raffaele, Nardone, Gabri, Nicoletti Carolina, Eduardo, Nobile-Orazio, Agostino, Nozzolillo, Marco, Onofrj, Riccardo, Orlandi, Anna, Palmieri, Damiano, Paolicelli, Livia, Pasquali, Fulvio, Pasquin, Luisa, Pastò, Francesco, Patti, Elisabetta, Pedrazzoli, Paola, Perini, Ilaria, Pesci, Maria, Petracca, Alfredo, Petrone, Carlo, Piantadosi, Anna M, Pietroboni, Federica, Pinardi, Marta, Ponzano, Emilio, Portaccio, Mattia, Pozzato, Carlo, Pozzilli, Luca, Prosperini, Alessandra, Protti, Eugenio, Pucci, Marta, Radaelli, Paolo, Ragonese, Sarah, Rasia, Sabrina, Realmuto, Anna, Repice, Eleonora, Rigoni, Teresa, Rilla Maria, Francesca, Rinaldi, Marcello, Romano Calogero, Marco, Ronzoni, Marco, Rovaris, Francesca, Ruscica, Loredana, Sabattini, Giuseppe, Salemi, Marco, Salvetti, Lorenzo, Saraceno, Alessia, Sartori, Arianna, Sartori, Elvira, Sbragia, Cinzia, Scandellari, Ilaria, Scarano Giuditta, Valentina, Scarano, Irene, Schiavetti, Maria, Sessa, Caterina, Sgarito, Grazia, Sibilia, Gabriele, Siciliano, Alessio, Signori, Elisabetta, Signoriello, Leonardo, Sinisi, Francesca, Sireci, Patrizia, Sola, Claudio, Solaro, Pia, Sormani Maria, Stefano, Sotgiu, Maddalena, Sparaco, Laura, Stromillo Maria, Silvia, Strumia, Laura, Susani Emanuela, Giulietta, Tabiadon, Francesco, Teatini, Gioacchino, Tedeschi, Valentina, Tomassini, Simone, Tonietti, Valentina, Torri Clerici, Carla, Tortorella, Simona, Toscano, Rocco, Totaro, Maria, Trojano, Maria, Trotta, Gabriella, Turano, Monica, Ulivelli, Manzo, Valentino, Giovanna, Vaula, Domizia, Vecchio, Marco, Vercellino, Pinuccia, Verrengia Elena, Marika, Vianello, Eleonora, Virgilio, Francesca, Vitetta, Stefano, Vollaro, Mauro, Zaffaroni, Mauro, Zampolini, Roberto, Zarbo Ignazio, Antonio, Zito, Luigi, Zuliani, Ponzano, Marta, Schiavetti, Irene, Bergamaschi, Roberto, Pisoni, Enrico, Bellavia, Andrea, Mallucci, Giulia, Carmisciano, Luca, Inglese, Matilde, Cordioli, Cinzia, Marfia, Girolama Alessandra, Cocco, Eleonora, Immovilli, Paolo, Pesci, Ilaria, Scandellari, Cinzia, Cavalla, Paola, Radaelli, Marta, Vianello, Marika, Vitetta, Francesca, Montepietra, Sara, Amato, Maria Pia, Fioretti, Cristina, Filippi, Massimo, Sartori, Arianna, Caleri, Francesca, Clerico, Marinella, Gallo, Antonio, Conte, Antonella, Clerici, Raffaella, De Luca, Giovanna, Boneschi, Filippo Martinelli, Cantello, Roberto, Calabrese, Massimiliano, Tortorella, Carla, Rovaris, Marco, Verrengia, Elena Pinuccia, Patti, Francesco, Morra, Vincenzo Brescia, Salvetti, Marco, and Sormani, Maria Pia
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- 2022
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17. Accuracy of QuantiFERON SARS-CoV-2 research use only assay and characterization of the CD4+ and CD8+ T cell-SARS-CoV-2 response: comparison with a homemade interferon-γ release assay
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Aiello, Alessandra, Coppola, Andrea, Vanini, Valentina, Petrone, Linda, Cuzzi, Gilda, Salmi, Andrea, Altera, Anna Maria Gerarda, Tortorella, Carla, Gualano, Gina, Gasperini, Claudio, Scolieri, Palma, Beccacece, Alessia, Vita, Serena, Bruzzese, Vincenzo, Lorenzetti, Roberto, Palmieri, Fabrizio, Nicastri, Emanuele, and Goletti, Delia
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- 2022
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18. Increased risk of death from COVID-19 in multiple sclerosis: a pooled analysis of observational studies
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Prosperini, Luca, Tortorella, Carla, Haggiag, Shalom, Ruggieri, Serena, Galgani, Simonetta, and Gasperini, Claudio
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- 2022
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19. Brain reserve and timing of clinical onset in multiple sclerosis.
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Petracca, Maria, Ruggieri, Serena, Nistri, Riccardo, Tomasso, Ilaria, Barbuti, Elena, Pozzilli, Valeria, Haggiag, Shalom, Tortorella, Carla, Gasperini, Claudio, Pozzilli, Carlo, and Prosperini, Luca
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PROPORTIONAL hazards models ,CENTRAL nervous system ,NEURAL development ,SYMPTOMS ,MULTIPLE sclerosis - Abstract
Background: A latent period of variable length elapses between multiple sclerosis (MS) biological onset and the occurrence of the first clinical episode reflecting a central nervous system (CNS) demyelinating event. Factors affecting the duration of such interval are unknown. Objective: To explore whether brain reserve, which moderates the impact of structural damage along MS course, could also affect the timing of MS clinical onset. Methods: We conducted a time-to-event analysis in 326 relapsing-onset multiple sclerosis patients to ascertain the effect of brain reserve, that is, larger maximal lifetime brain growth (MLBG) estimated as intracranial volume, on the risk of an earlier disease onset. For this purpose, we carried out a Cox proportional hazards regression model stratified by sex and adjusted by site and pre-morbid MS risk factors. All patients reached the event (i.e. the disease onset) with no censored case; the age (years) at disease onset was set as the main time variable. Results: We identified a protective effect of brain reserve on the time to disease onset (HR = 0.11, 95% CI = 0.02–0.83, p = 0.032), unchanged when accounting for MS risk factors. Conclusion: Brain reserve might counteract the pathological mechanisms ongoing after biological initiation, thus delaying the disease overt clinical manifestation. [ABSTRACT FROM AUTHOR]
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- 2024
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20. Disability patterns in multiple sclerosis: A meta-analysis on RAW and PIRA in the real-world context.
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Prosperini, Luca, Ruggieri, Serena, Haggiag, Shalom, Tortorella, Carla, and Gasperini, Claudio
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SCIENCE databases ,MULTIPLE sclerosis ,SCIENTIFIC method ,CONFIDENCE intervals ,DISABILITIES - Abstract
Objective: To summarize the current evidence on relapse-associated worsening (RAW) and progression independent of relapse activity (PIRA) through a quantitative synthesis of real-world studies. Methods: Scientific databases were searched to identify suitable articles. Random-effects meta-analyses, subgroup analyses and meta-regression models were ran to provide pooled estimates of RAW and PIRA events and to identify their potential moderators (PROSPERO registration: CRD42024503895). Results: Eighteen articles met the eligibility criteria, with a pooled sample size of 52,667 patients (93% relapsing–remitting, 6% clinically isolated syndrome and 1% progressive) followed for 2.4 to 12.1 years, yielding to 415,825 patient-years. Pooled event rates for RAW and PIRA were 1.6 (95 confidence interval (CI) = 1.1–2.1) and 3.1 (95% CI = 2.3–3.9) per 100 patient-years, respectively. Less RAW events were found in cohorts including patients with progressive course (β = −0.069, p = 0.006) and under high-efficacy disease-modifying treatments (DMTs) (β = −0.031, p = 0.007), while PIRA events were directly related to older age (β = 0.397, p = 0.027). In addition, we found significant differences in PIRA event rates according to the criteria adopted to define confirmed disability accrual (p < 0.05). Discussion: PIRA accounts for most events causing disability accumulation in the real-world setting, even at the earlier disease stages, whereas RAW represents a less frequent phenomenon, likely due to effective treatments. The detection and statistical analysis of PIRA outcomes pose challenges, raising the risk of erroneous inference. When interpreting our findings, caution is needed given the wide heterogeneity of included studies. [ABSTRACT FROM AUTHOR]
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- 2024
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21. Cortical plasticity in AQP4-positive NMOSD: a transcranial magnetic stimulation study.
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Cruciani, Alessandro, Capone, Fioravante, Haggiag, Shalom, Prosperini, Luca, Santoro, Francesca, Ruggieri, Serena, Motolese, Francesco, Pilato, Fabio, Musumeci, Gabriella, Pozzilli, Valeria, Rossi, Mariagrazia, Bassi, Mario Stampanoni, Buttari, Fabio, Centonze, Diego, Lazzaro, Vincenzo Di, Gasperini, Claudio, and Tortorella, Carla
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- 2024
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22. Anti-RBD Antibody Levels and IFN-γ-Specific T Cell Response Are Associated with a More Rapid Swab Reversion in Patients with Multiple Sclerosis after the Booster Dose of COVID-19 Vaccination.
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Aiello, Alessandra, Ruggieri, Serena, Navarra, Assunta, Tortorella, Carla, Vanini, Valentina, Haggiag, Shalom, Prosperini, Luca, Cuzzi, Gilda, Salmi, Andrea, Quartuccio, Maria Esmeralda, Altera, Anna Maria Gerarda, Meschi, Silvia, Matusali, Giulia, Vita, Serena, Galgani, Simonetta, Maggi, Fabrizio, Nicastri, Emanuele, Gasperini, Claudio, and Goletti, Delia
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BOOSTER vaccines ,BREAKTHROUGH infections ,COVID-19 vaccines ,ANTIBODY formation ,T cells - Abstract
This study investigated the incidence and severity of SARS-CoV-2 breakthrough infections (BIs) and the time to swab reversion in patients with multiple sclerosis (PwMS) after the booster dose of COVID-19 mRNA vaccines. We enrolled 64 PwMS who had completed the three-dose mRNA vaccine schedule and had never experienced COVID-19 before. Among the 64 PwMS, 43.8% had BIs with a median time since the third vaccine dose of 155 days. BIs occurred more frequently in ocrelizumab-treated patients (64.7%). Patients with a relapsing-remitting MS course showed a reduced incidence of BIs compared with those with a primary-progressive disease (p = 0.002). Having anti-receptor-binding domain (RBD) antibodies represented a protective factor reducing the incidence of BIs by 60% (p = 0.042). The majority of BIs were mild, and the only severe COVID-19 cases were reported in patients with a high Expanded Disability Status Scale score (EDSS > 6). The median time for a negative swab was 11 days. Notably, fingolimod-treated patients take longer for a swab-negativization (p = 0.002). Conversely, having anti-RBD antibodies ≥ 809 BAU/mL and an IFN-γ-specific T cell response ≥ 16 pg/mL were associated with a shorter time to swab-negativization (p = 0.051 and p = 0.018, respectively). In conclusion, the immunological protection from SARS-CoV-2 infection may differ among PwMS according to DMTs. [ABSTRACT FROM AUTHOR]
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- 2024
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23. Disability patterns in multiple sclerosis: a meta-analysis on PIRA and RAW in the real world context
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Prosperini, Luca, primary, Ruggieri, Serena, additional, Haggiag, Shalom, additional, Tortorella, Carla, additional, and Gasperini, Claudio, additional
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- 2024
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24. Clinical course of central nervous system demyelinating neurological adverse events associated with anti-TNF therapy
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Cortese, Rosa, Prosperini, Luca, Stasolla, Alessandro, Haggiag, Shalom, Villani, Veronica, Simone, Isabella Laura, Gasperini, Claudio, and Tortorella, Carla
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- 2021
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25. Predictors of lymphocyte count recovery after dimethyl fumarate-induced lymphopenia in people with multiple sclerosis
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Lucchini, Matteo, Prosperini, Luca, Buscarinu, Maria Chiara, Centonze, Diego, Conte, Antonella, Cortese, Antonio, Elia, Giorgia, Fantozzi, Roberta, Ferraro, Elisabetta, Gasperini, Claudio, Ianniello, Antonio, Landi, Doriana, Marfia, Girolama Alessandra, Nociti, Viviana, Pozzilli, Carlo, Salvetti, Marco, Tortorella, Carla, and Mirabella, Massimiliano
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- 2021
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26. Incidence and determinants of seizures in multiple sclerosis: a meta-analysis of randomised clinical trials.
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Pozzilli, Valeria, Haggiag, Shalom, Di Filippo, Massimiliano, Capone, Fioravante, Di Lazzaro, Vincenzo, Tortorella, Carla, Gasperini, Claudio, and Prosperini, Luca
- Subjects
EPILEPSY ,MULTIPLE sclerosis ,SEIZURES (Medicine) ,CLINICAL trials ,TRP channels - Published
- 2024
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27. Radiological Reporting Systems in Multiple Sclerosis.
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Scaravilli, Alessandra, Tranfa, Mario, Pontillo, Giuseppe, Carotenuto, Antonio, Lapucci, Caterina, Nistri, Riccardo, Signoriello, Elisabetta, Moccia, Marcello, Tortorella, Carla, Capra, Ruggero, Lus, Giacomo, Inglese, Matilde, Gasperini, Claudio, Lanzillo, Roberta, Pozzilli, Carlo, Brescia Morra, Vincenzo, Brunetti, Arturo, Petracca, Maria, and Cocozza, Sirio
- Subjects
MULTIPLE sclerosis ,CEREBRAL atrophy ,MEDICAL software ,DIAGNOSTIC imaging ,NEUROLOGISTS ,PICTURE archiving & communication systems - Abstract
(1) Background: Although MRI is a well-established tool in Multiple Sclerosis (MS) diagnosis and management, neuroradiological reports often lack standardization and/or quantitative information, with possible consequences in clinical care. The aim of this study was to evaluate the impact of information provided by neuroradiological reports and different reporting systems on the clinical management of MS patients. (2) Methods: An online questionnaire was proposed to neurologists working in Italian tertiary care level MS centers. Questions assessed the impact of different MRI-derived biomarkers on clinical choices, the preferred way of receiving radiological information, and the neurologists' opinions about different reporting systems and the use of automated software in clinical practice. (3) Results: The online survey was completed by 62 neurologists. New/enlarging (100%) lesions, the global T2w/FLAIR lesion load (96.8%), and contrast-enhancing (95.2%) lesions were considered the most important biomarkers for therapeutic decision, while new/enlarging lesions (98.4%), global T2w/FLAIR lesion load (96.8%), and cerebral atrophy (90.3%) were relevant to prognostic evaluations. Almost all participants (98.4%) considered software for medical imaging quantification helpful in clinical management, mostly in relation to prognostic evaluations. (4) Conclusions: These data highlight the impact of providing accurate and reliable data in neuroradiological reports. The use of software for medical imaging quantification in MS can be helpful to standardize radiological reports and to provide useful clinical information to neurologists. [ABSTRACT FROM AUTHOR]
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- 2024
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28. Characteristics and treatment of Multiple Sclerosis-related trigeminal neuralgia: An Italian multi-centre study
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Ferraro, Diana, Annovazzi, Pietro, Moccia, Marcello, Lanzillo, Roberta, De Luca, Giovanna, Nociti, Viviana, Fantozzi, Roberta, Paolicelli, Damiano, Ragonese, Paolo, Gajofatto, Alberto, Boffa, Laura, Cavalla, Paola, Lo Fermo, Salvatore, Buscarinu, Maria Chiara, Lorefice, Lorena, Cordioli, Cinzia, Calabrese, Massimiliano, Gallo, Antonio, Pinardi, Federica, Tortorella, Carla, Di Filippo, Massimiliano, Camera, Valentina, Maniscalco, Giorgia Teresa, Radaelli, Marta, Buttari, Fabio, Tomassini, Valentina, Cocco, Eleonora, Gasperini, Claudio, and Solaro, Claudio
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- 2020
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29. Humoral- and T-Cell–Specific Immune Responses to SARS-CoV-2 mRNA Vaccination in Patients With MS Using Different Disease-Modifying Therapies
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Tortorella, Carla, Aiello, Alessandra, Gasperini, Claudio, Agrati, Chiara, Castilletti, Concetta, Ruggieri, Serena, Meschi, Silvia, Matusali, Giulia, Colavita, Francesca, Farroni, Chiara, Cuzzi, Gilda, Cimini, Eleonora, Tartaglia, Eleonora, Vanini, Valentina, Prosperini, Luca, Haggiag, Shalom, Galgani, Simona, Quartuccio, Maria Esmeralda, Salmi, Andrea, Repele, Federica, Gerarda Altera, Anna Maria, Cristofanelli, Flavia, DʼAbramo, Alessandra, Bevilacqua, Nazario, Corpolongo, Angela, Puro, Vincenzo, Vaia, Francesco, Capobianchi, Maria Rosaria, Ippolito, Giuseppe, Nicastri, Emanuele, and Goletti, Delia
- Published
- 2021
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30. Adding the Optic Nerve in Multiple Sclerosis Diagnostic Criteria
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Vidal-Jordana, Angela, primary, Rovira, Alex, additional, Calderon, Willem, additional, Arrambide, Georgina, additional, Castilló, Joaquín, additional, Moncho, Dulce, additional, Rahnama, Kimia, additional, Collorone, Sara, additional, Toosy, Ahmed T., additional, Ciccarelli, Olga, additional, Papadopoulou, Athina, additional, Cerdá-Fuertes, Nuria, additional, Lieb, Johanna M., additional, Ruggieri, Serena, additional, Tortorella, Carla, additional, Gasperini, Claudio, additional, Bisecco, Alvino, additional, Capuano, Rocco, additional, Gallo, Antonio, additional, De Barros, Andrea, additional, Salerno, Annalaura, additional, Auger, Cristina, additional, Sastre-Garriga, Jaume, additional, Tintore, Mar, additional, and Montalban, Xavier, additional
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- 2024
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31. Induction Versus Escalation in Multiple Sclerosis: A 10-Year Real World Study
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Prosperini, Luca, Mancinelli, Chiara Rosa, Solaro, Claudio Marcello, Nociti, Viviana, Haggiag, Shalom, Cordioli, Cinzia, De Giglio, Laura, De Rossi, Nicola, Galgani, Simonetta, Rasia, Sarah, Ruggieri, Serena, Tortorella, Carla, Capra, Ruggero, Mirabella, Massimiliano, and Gasperini, Claudio
- Published
- 2020
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32. Exit strategies for “needle fatigue” in multiple sclerosis: a propensity score-matched comparison study
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Prosperini, Luca, Cortese, Antonio, Lucchini, Matteo, Boffa, Laura, Borriello, Giovanna, Buscarinu, Maria Chiara, Capone, Fioravante, Centonze, Diego, De Fino, Chiara, De Pascalis, Daniela, Fantozzi, Roberta, Ferraro, Elisabetta, Filippi, Maria, Galgani, Simonetta, Gasperini, Claudio, Haggiag, Shalom, Landi, Doriana, Marfia, Girolama, Mataluni, Giorgia, Millefiorini, Enrico, Mirabella, Massimiliano, Monteleone, Fabrizia, Nociti, Viviana, Pontecorvo, Simona, Romano, Silvia, Ruggieri, Serena, Salvetti, Marco, Tortorella, Carla, Zannino, Silvana, and Di Battista, Giancarlo
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- 2020
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33. COVID-19 Severity in Multiple Sclerosis: Putting Data Into Context
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Sormani, Maria Pia, Schiavetti, Irene, Carmisciano, Luca, Cordioli, Cinzia, Filippi, Massimo, Radaelli, Marta, Immovilli, Paolo, Capobianco, Marco, De Rossi, Nicola, Brichetto, Giampaolo, Cocco, Eleonora, Scandellari, Cinzia, Cavalla, Paola, Pesci, Ilaria, Zito, Antonio, Confalonieri, Paolo, Marfia, Girolama Alessandra, Perini, Paola, Inglese, Matilde, Trojano, Maria, Brescia Morra, Vincenzo, Tedeschi, Gioacchino, Comi, Giancarlo, Battaglia, Mario Alberto, Patti, Francesco, Salvetti, Marco, Abbadessa, Gianmarco, Aguglia, Umberto, Allegorico, Lia, Allegri Rossi, Beatrice Maria, Amato, Maria Pia, Annovazzi, Pietro, Antozzi, Carlo, Appendino, Lucia, Arena, Sebastiano, Baione, Viola, Balgera, Roberto, Barcella, Valeria, Baroncini, Damiano, Barrilà, Caterina, Bellacosa, Alessandra, Bellucci, Gianmarco, Bergamaschi, Roberto, Bergamaschi, Valeria, Bezzini, Daiana, Biolzi, Beatrice, Bisecco, Alvino, Bonavita, Simona, Borriello, Giovanna, Bosa, Chiara, Bosco, Antonio, Bovis, Francesca, Bozzali, Marco, Brambilla, Laura, Buccafusca, Maria, Bucciantini, Elisabetta, Bucello, Sebastiano, Buscarinu, Maria Chiara, Cabboi, Maria Paola, Calabrese, Massimiliano, Calabria, Francesca, Caleri, Francesca, Camilli, Federico, Caniatti, Luisa Maria, Cantello, Roberto, Capra, Ruggero, Capuano, Rocco, Carta, Patrizia, Celani, Maria Grazia, Cellerino, Maria, Cerqua, Raffaella, Chisari, Clara, Clerici, Raffaella, Clerico, Marinella, Cola, Gaia, Conte, Antonella, Conti, Marta Zaffira, Cordano, Christian, Cordera, Susanna, Corea, Francesco, Correale, Claudio, Cottone, Salvatore, Crescenzo, Francesco, Curti, Erica, dʼAmbrosio, Alessandro, DʼAmico, Emanuele, Danni, Maura Chiara, dʼArma, Alessia, Dattola, Vincenzo, de Biase, Stefano, Luca, Giovanna De, Mercanti, Stefania Federica De, De Mitri, Paolo, De Stefano, Nicola, Cava, Marco Della, Napoli, Mario di, Sapio, Alessia Di, Docimo, Renato, Dutto, Anna, Evangelista, Luana, Fanara, Salvatore, Diana, Ferraro, Ferrò, Maria Teresa, Fioretti, Cristina, Fratta, Mario, Frau, Jessica, Fronza, Marzia, Furlan, Roberto, Gajofatto, Alberto, Gallo, Antonio, Gallo, Paolo, Gasperini, Claudio, Ghazaryan, Anna, Giometto, Bruno, Gobbin, Francesca, Govone, Flora, Granella, Franco, Grange, Erica, Grasso, Maria Grazia, Guareschi, Angelica, Guaschino, Clara, Guerrieri, Simone, Guidetti, Donata, Iaffaldano, Pietro, Ianniello, Antonio, Iasevoli, Luigi, Imperiale, Daniele, Infante, Maria Teresa, Iodice, Rosa, Iovino, Aniello, Konrad, Giovanna, Landi, Doriana, Lanzillo, Roberta, Lapucci, Caterina, Lavorgna, Luigi, LʼEpiscopo, Maria Rita, Leva, Serena, Liberatore, Giuseppe, Lo Re, Marianna, Longoni, Marco, Lopiano, Leonardo, Lorefice, Lorena, Lucchini, Matteo, Lus, Giacomo, Maimone, Davide, Malentacchi, Maria, Mallucci, Giulia, Malucchi, Simona, Mancinelli, Chiara Rosa, Mancinelli, Luca, Manganotti, Paolo, Maniscalco, Giorgia Teresa, Mantero, Vittorio, Marangoni, Sabrina, Marastoni, Damiano, Marinelli, Fabiana, Marti, Alessandro, Boneschi, Filippo Martinelli, Masserano Zoli, Federco, Matta, Francesca, Mendozzi, Laura, Meucci, Giuseppe, Miante, Silvia, Miele, Giuseppina, Milano, Eva, Mirabella, Massimiliano, Missione, Rosanna, Moccia, Marcello, Moiola, Lucia, Montepietra, Sara, MontiBragadin, Margherita, Montini, Federico, Motta, Roberta, Nardone, Raffaele, Nicoletti, Carolina Gabri, Nobile-Orazio, Eduardo, Nozzolillo, Agostino, Onofrj, Marco, Orlandi, Riccardo, Palmieri, Anna, Paolicelli, Damiano, Pasquali, Livia, Pastò, Luisa, Pedrazzoli, Elisabetta, Petracca, Maria, Petrone, Alfredo, Piantadosi, Carlo, Pietroboni, Anna M, Pinardi, Federica, Ponzano, Marta, Portaccio, Emilio, Pozzato, Mattia, Pozzilli, Carlo, Prosperini, Luca, Protti, Alessandra, Ragonese, Paolo, Rasia, Sarah, Realmuto, Sabrina, Repice, Anna, Rigoni, Eleonora, Rilla, Maria Teresa, Rinaldi, Francesca, Romano, Calogero Marcello, Ronzoni, Marco, Rovaris, Marco, Ruscica, Francesca, Sabattini, Loredana, Salemi, Giuseppe, Saraceno, Lorenzo, Sartori, Alessia, Sartori, Arianna, Sbragia, Elvira, Scarano, Giuditta Ilaria, Scarano, Valentina, Schillaci, Valentina, Sessa, Maria, Sgarito, Caterina, Sibilia, Grazia, Siciliano, Gabriele, Signori, Alessio, Signoriello, Elisabetta, Sinisi, Leonardo, Sireci, Francesca, Sola, Patrizia, Solaro, Claudio, Sotgiu, Stefano, Sparaco, Maddalena, Stromillo, Maria Laura, Strumia, Silvia, Susani, Emanuela Laura, Tabiadon, Giulietta, Teatini, Francesco, Tomassini, Valentina, Tonietti, Simone, Torri, Clerici Valentina, Tortorella, Carla, Toscano, Simona, Totaro, Rocco, Trotta, Maria, Turano, Gabriella, Ulivelli, Monica, Valentino, Manzo, Vaula, Giovanna, Vecchio, Domizia, Vercellino, Marco, Verrengia, Elena Pinuccia, Vianello, Marika, Virgilio, Eleonora, Vitetta, Francesca, Vollaro, Stefano, Zaffaroni, Mauro, Zampolini, Mauro, Zarbo, Ignazio Roberto, and Zuliani, Luigi
- Published
- 2022
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34. Disease-modifying therapies in managing disability worsening in paediatric-onset multiple sclerosis: a longitudinal analysis of global and national registries
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Sharmin, Sifat, Roos, Izanne, Malpas, Charles B, Iaffaldano, Pietro, Simone, Marta, Filippi, Massimo, Kubala Havrdova, Eva, Ozakbas, Serkan, Brescia Morra, Vincenzo, Alroughani, Raed, Zaffaroni, Mauro, Patti, Francesco, Eichau, Sara, Salemi, Giuseppe, Di Sapio, Alessia, Inglese, Matilde, Portaccio, Emilio, Trojano, Maria, Amato, Maria Pia, Kalincik, Tomas, Horakova, Dana, Prat, Alexandre, Girard, Marc, Duquette, Pierre, Boz, Cavit, Pozzilli, Carlo, Cocco, Eleonora, Gallo, Paolo, Yamout, Bassem, Khoury, Samia J., Lugaresi, Alessandra, Onofrj, Marco, Lus, Giacomo, Clerici, Valentina Torri, Maniscalco, Giorgia Teresa, Romano, Silvia, Tortorella, Carla, Valentino, Paola, Rovaris, Marco, Shaygannejad, Vahid, Ferraro, Diana, Vianello, Marika, Grammond, Pierre, Bergamaschi, Roberto, Gallo, Antonio, Cavalla, Paola, Sa, Maria Jose, Lechner-Scott, Jeannette, Pesci, Ilaria, Buzzard, Katherine, Gouider, Riadh, Mrabet, Saloua, Aguglia, Umberto, Conte, Antonella, Avolio, Carlo, Bellantonio, Paolo, John, Nevin, Cartechini, Elisabetta, De Robertis, Francesca, Ferraro, Elisabetta, Weinstock-Guttman, Bianca, Barcella, Valeria, Van der Walt, Anneke, Butzkueven, Helmut, Coniglio, Maria Gabriella, Granella, Franco, Kuhle, Jens, Marfia, Girolama Alessandra, Laureys, Guy, Van Hijfte, Liesbeth, Maimone, Davide, Gazzola, Paola, Blanco, Yolanda, Turkoglu, Recai, Montepietra, Sara, Spitaleri, Daniele, van Pesch, Vincent, Gerlach, Oliver, Prevost, Julie, Ampapa, Radek, Soysal, Aysun, Altintas, Ayse, Rini, Augusto, Solaro, Claudio, Protti, Alessandra, Foschi, Matteo, Surcinelli, Andrea, Gatto, Maurizia, Mascoli, Nerina, De Riz, Milena, Realmuto, Sabrina, Rossi, Patrizia, Totaro, Rocco, Barnett, Michael, Oh, Jiwon, Nasuelli, Davide, Ramo-Tello, Cristina, Sanchez-Menoyo, Jose Luis, Al-Harbi, Talal, Fioretti, Cristina, Bucello, Sebastiano, Cargnelutti, Daniela, and Vukusic, Sandra
- Abstract
High-efficacy disease-modifying therapies have been proven to slow disability accrual in adults with relapsing–remitting multiple sclerosis. However, their impact on disability worsening in paediatric-onset multiple sclerosis, particularly during the early phases, is not well understood. We evaluated how high-efficacy therapies influence transitions across five disability states, ranging from minimal disability to gait impairment and secondary progressive multiple sclerosis, in people with paediatric-onset multiple sclerosis.
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- 2024
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35. Prognostic Accuracy of NEDA-3 in Long-term Outcomes of Multiple Sclerosis
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Prosperini, Luca, Ruggieri, Serena, Haggiag, Shalom, Tortorella, Carla, Pozzilli, Carlo, and Gasperini, Claudio
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- 2021
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36. Assessing treatment response to oral drugs for multiple sclerosis in real-world setting: a MAGNIMS Study
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Ruggieri, Serena, primary, Prosperini, Luca, additional, Al-Araji, Sarmad, additional, Annovazzi, Pietro Osvaldo, additional, Bisecco, Alvino, additional, Ciccarelli, Olga, additional, De Stefano, Nicola, additional, Filippi, Massimo, additional, Fleischer, Vinzenz, additional, Evangelou, Nikos, additional, Enzinger, Christian, additional, Gallo, Antonio, additional, Garjani, Afagh, additional, Groppa, Sergiu, additional, Haggiag, Shalom, additional, Khalil, Michael, additional, Lucchini, Matteo, additional, Mirabella, Massimiliano, additional, Montalban, Xavier, additional, Pozzilli, Carlo, additional, Preziosa, Paolo, additional, Río, Jordi, additional, Rocca, Maria A, additional, Rovira, Alex, additional, Stromillo, Maria L, additional, Zaffaroni, Mauro, additional, Tortorella, Carla, additional, and Gasperini, Claudio, additional
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- 2023
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37. Non-alcoholic Wernicke encephalopathy presenting as bilateral hearing loss: a case report
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Prosperini, Luca, Stasolla, Alessandro, Grieco, Gabriella, Gerace, Carmela, and Tortorella, Carla
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- 2019
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38. Dimethyl fumarate or teriflunomide for relapsing-remitting multiple sclerosis: a meta-analysis of post-marketing studies
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Prosperini, Luca, primary, Haggiag, Shalom, additional, Ruggieri, Serena, additional, Tortorella, Carla, additional, and Gasperini, Claudio, additional
- Published
- 2023
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39. Symptomatic COVID-19 course and outcomes after three mRNA vaccine doses in multiple sclerosis patients treated with high-efficacy DMTs
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Capuano, Rocco, primary, Prosperini, Luca, additional, Altieri, Manuela, additional, Lorefice, Lorena, additional, Fantozzi, Roberta, additional, Cavalla, Paola, additional, Guaschino, Clara, additional, Radaelli, Marta, additional, Cordioli, Cinzia, additional, Nociti, Viviana, additional, Boffa, Laura, additional, Ragonese, Paolo, additional, Di Gregorio, Maria, additional, Pinardi, Federica, additional, Torri Clerici, Valentina, additional, De Luca, Giovanna, additional, Gajofatto, Alberto, additional, Paolicelli, Damiano, additional, Tortorella, Carla, additional, Gasperini, Claudio, additional, Solaro, Claudio, additional, Cocco, Eleonora, additional, Bisecco, Alvino, additional, and Gallo, Antonio, additional
- Published
- 2023
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40. Dynamic Evolution of Humoral and T-Cell Specific Immune Response to COVID-19 mRNA Vaccine in Patients with Multiple Sclerosis Followed until the Booster Dose
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Ruggieri, Serena, primary, Aiello, Alessandra, additional, Tortorella, Carla, additional, Navarra, Assunta, additional, Vanini, Valentina, additional, Meschi, Silvia, additional, Lapa, Daniele, additional, Haggiag, Shalom, additional, Prosperini, Luca, additional, Cuzzi, Gilda, additional, Salmi, Andrea, additional, Quartuccio, Maria Esmeralda, additional, Altera, Anna Maria Gerarda, additional, Garbuglia, Anna Rosa, additional, Ascoli Bartoli, Tommaso, additional, Galgani, Simonetta, additional, Notari, Stefania, additional, Agrati, Chiara, additional, Puro, Vincenzo, additional, Nicastri, Emanuele, additional, Gasperini, Claudio, additional, and Goletti, Delia, additional
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- 2023
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41. A multicentRE observational analysiS of PErsistenCe to Treatment in the new multiple sclerosis era: the RESPECT study
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Lanzillo, Roberta, Prosperini, Luca, Gasperini, Claudio, Moccia, Marcello, Fantozzi, Roberta, Tortorella, Carla, Nociti, Viviana, Annovazzi, Pietro, Cavalla, Paola, Radaelli, Marta, Malucchi, Simona, Clerici, Valentina Torri, Boffa, Laura, Buttari, Fabio, Ragonese, Paolo, Maniscalco, Giorgia Teresa, Di Filippo, Massimiliano, Buscarinu, Maria Chiara, Pinardi, Federica, Gallo, Antonio, Coghe, Giancarlo, Pesci, Ilaria, Laroni, Alice, Gajofatto, Alberto, Calabrese, Massimiliano, Tomassini, Valentina, Cocco, Eleonora, Solaro, Claudio, and R.I.Re.MS study group
- Published
- 2018
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42. Assessing treatment response to oral drugs for multiple sclerosis in real-world setting: a MAGNIMS Study
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Ruggieri, Serena, Prosperini, Luca, Al-Araji, Sarmad, Annovazzi, Pietro Osvaldo, Bisecco, Alvino, Ciccarelli, Olga, De Stefano, Nicola, Filippi, Massimo, Fleischer, Vinzenz, Evangelou, Niko, Enzinger, Christian, Gallo, Antonio, Garjani, Afagh, Groppa, Sergiu, Haggiag, Shalom, Khalil, Michael, Lucchini, Matteo, Mirabella, Massimiliano, Montalban, Xavier, Pozzilli, Carlo, Preziosa, Paolo, Río, Jordi, Rocca, Maria A, Rovira, Alex, Stromillo, Maria L, Zaffaroni, Mauro, Tortorella, Carla, Gasperini, Claudio, Lucchini, Matteo (ORCID:0000-0002-0447-2297), Mirabella, Massimiliano (ORCID:0000-0002-7783-114X), Ruggieri, Serena, Prosperini, Luca, Al-Araji, Sarmad, Annovazzi, Pietro Osvaldo, Bisecco, Alvino, Ciccarelli, Olga, De Stefano, Nicola, Filippi, Massimo, Fleischer, Vinzenz, Evangelou, Niko, Enzinger, Christian, Gallo, Antonio, Garjani, Afagh, Groppa, Sergiu, Haggiag, Shalom, Khalil, Michael, Lucchini, Matteo, Mirabella, Massimiliano, Montalban, Xavier, Pozzilli, Carlo, Preziosa, Paolo, Río, Jordi, Rocca, Maria A, Rovira, Alex, Stromillo, Maria L, Zaffaroni, Mauro, Tortorella, Carla, Gasperini, Claudio, Lucchini, Matteo (ORCID:0000-0002-0447-2297), and Mirabella, Massimiliano (ORCID:0000-0002-7783-114X)
- Abstract
Background: The assessment of treatment response is a crucial step for patients with relapsing-remitting multiple sclerosis on disease-modifying therapies (DMTs). We explored whether a scoring system developed within the MAGNIMS (MRI in Multiple Sclerosis) network to evaluate treatment response to injectable drugs can be adopted also to oral DMTs. Methods: A multicentre dataset of 1200 patients who started three oral DMTs (fingolimod, teriflunomide and dimethyl fumarate) was collected within the MAGNIMS network. Disease activity after the first year was classified by the 'MAGNIMS' score based on the combination of relapses (0-≥2) and/or new T2 lesions (<3 or ≥3) on brain MRI. We explored the association of this score with the following 3-year outcomes: (1) confirmed disability worsening (CDW); (2) treatment failure (TFL); (3) relapse count between years 1 and 3. The additional value of contrast-enhancing lesions (CELs) and lesion location was explored. Results: At 3 years, 160 patients experienced CDW: 12% of them scored '0' (reference), 18% scored '1' (HR=1.82, 95% CI 1.20 to 2.76, p=0.005) and 37% scored '2' (HR=2.74, 95% CI 1.41 to 5.36, p=0.003) at 1 year. The analysis of other outcomes provided similar findings. Considering the location of new T2 lesions (supratentorial vs infratentorial/spinal cord) and the presence of CELs improved the prediction of CDW and TFL, respectively, in patients with minimal MRI activity alone (one or two new T2 lesions). Conclusions: Early relapses and substantial MRI activity in the first year of treatment are associated with worse short-term outcomes in patients treated with some of the oral DMTs.
- Published
- 2023
43. Assessing treatment response to oral drugs for multiple sclerosis in real-world setting: a MAGNIMS Study
- Author
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Ruggieri, Serena, Prosperini, Luca, Al-Araji, Sarmad, Annovazzi, Pietro Osvaldo, Bisecco, Alvino, Ciccarelli, Olga, De Stefano, Nicola, Filippi, Massimo, Fleischer, Vinzenz, Evangelou, Nikos, Enzinger, Christian, Gallo, Antonio, Garjani, Afagh, Groppa, Sergiu, Haggiag, Shalom, Khalil, Michael, Lucchini, Matteo, Mirabella, Massimiliano, Montalban, Xavier, Pozzilli, Carlo, Preziosa, Paolo, Río, Jordi, Rocca, Maria A, Rovira, Alex, Stromillo, Maria L, Zaffaroni, Mauro, Tortorella, Carla, and Gasperini, Claudio
- Abstract
BackgroundThe assessment of treatment response is a crucial step for patients with relapsing-remitting multiple sclerosis on disease-modifying therapies (DMTs). We explored whether a scoring system developed within the MAGNIMS (MRI in Multiple Sclerosis) network to evaluate treatment response to injectable drugs can be adopted also to oral DMTs.MethodsA multicentre dataset of 1200 patients who started three oral DMTs (fingolimod, teriflunomide and dimethyl fumarate) was collected within the MAGNIMS network. Disease activity after the first year was classified by the ‘MAGNIMS’ score based on the combination of relapses (0–≥2) and/or new T2 lesions (<3 or ≥3) on brain MRI. We explored the association of this score with the following 3-year outcomes: (1) confirmed disability worsening (CDW); (2) treatment failure (TFL); (3) relapse count between years 1 and 3. The additional value of contrast-enhancing lesions (CELs) and lesion location was explored.ResultsAt 3 years, 160 patients experienced CDW: 12% of them scored ‘0’ (reference), 18% scored ‘1’ (HR=1.82, 95% CI 1.20 to 2.76, p=0.005) and 37% scored ‘2’ (HR=2.74, 95% CI 1.41 to 5.36, p=0.003) at 1 year. The analysis of other outcomes provided similar findings. Considering the location of new T2 lesions (supratentorial vs infratentorial/spinal cord) and the presence of CELs improved the prediction of CDW and TFL, respectively, in patients with minimal MRI activity alone (one or two new T2 lesions).ConclusionsEarly relapses and substantial MRI activity in the first year of treatment are associated with worse short-term outcomes in patients treated with some of the oral DMTs.
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- 2024
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44. “Better explanations” in multiple sclerosis diagnostic workup: A 3-year longitudinal study
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Calabrese, Massimiliano, Gasperini, Claudio, Tortorella, Carla, Schiavi, Gianmarco, Frisullo, Giovanni, Ragonese, Paolo, Fantozzi, Roberta, Prosperini, Luca, Annovazzi, Pietro, Cordioli, Cinzia, Di Filippo, Massimiliano, Ferraro, Diana, Gajofatto, Alberto, Malucchi, Simona, Lo Fermo, Salvatore, De Luca, Giovanna, Stromillo, Maria L., Cocco, Eleonora, Gallo, Antonio, Paolicelli, Damiano, Lanzillo, Roberta, Tomassini, Valentina, Pesci, Ilaria, Rodegher, Maria E., and Solaro, Claudio
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- 2019
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45. Pregnancy and antibody-mediated CNS disorders: What do we know and what should we know?
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Cortese, Rosa, primary, Mariotto, Sara, additional, Mancinelli, Chiara Rosa, additional, and Tortorella, Carla, additional
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- 2022
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46. Longitudinal characterisation of B and T-cell immune responses after the booster dose of COVID-19 mRNA-vaccine in people with multiple sclerosis using different disease-modifying therapies
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Aiello, Alessandra, primary, Coppola, Andrea, additional, Ruggieri, Serena, additional, Farroni, Chiara, additional, Altera, Anna Maria Gerarda, additional, Salmi, Andrea, additional, Vanini, Valentina, additional, Cuzzi, Gilda, additional, Petrone, Linda, additional, Meschi, Silvia, additional, Lapa, Daniele, additional, Bettini, Aurora, additional, Haggiag, Shalom, additional, Prosperini, Luca, additional, Galgani, Simonetta, additional, Quartuccio, Maria Esmeralda, additional, Bevilacqua, Nazario, additional, Garbuglia, Anna Rosa, additional, Agrati, Chiara, additional, Puro, Vincenzo, additional, Tortorella, Carla, additional, Gasperini, Claudio, additional, Nicastri, Emanuele, additional, and Goletti, Delia, additional
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- 2022
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47. The impact of PM2.5, PM10 and NO2 on Covid-19 severity in a sample of patients with multiple sclerosis: A case-control study
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Ponzano, Marta, primary, Schiavetti, Irene, additional, Bergamaschi, Roberto, additional, Pisoni, Enrico, additional, Bellavia, Andrea, additional, Mallucci, Giulia, additional, Carmisciano, Luca, additional, Inglese, Matilde, additional, Cordioli, Cinzia, additional, Marfia, Girolama Alessandra, additional, Cocco, Eleonora, additional, Immovilli, Paolo, additional, Pesci, Ilaria, additional, Scandellari, Cinzia, additional, Cavalla, Paola, additional, Radaelli, Marta, additional, Vianello, Marika, additional, Vitetta, Francesca, additional, Montepietra, Sara, additional, Amato, Maria Pia, additional, Fioretti, Cristina, additional, Filippi, Massimo, additional, Sartori, Arianna, additional, Caleri, Francesca, additional, Clerico, Marinella, additional, Gallo, Antonio, additional, Conte, Antonella, additional, Clerici, Raffaella, additional, De Luca, Giovanna, additional, Boneschi, Filippo Martinelli, additional, Cantello, Roberto, additional, Calabrese, Massimiliano, additional, Tortorella, Carla, additional, Rovaris, Marco, additional, Verrengia, Elena Pinuccia, additional, Patti, Francesco, additional, Morra, Vincenzo Brescia, additional, Salvetti, Marco, additional, Sormani, Maria Pia, additional, Gianmarco, Abbadessa, additional, Umberto, Aguglia, additional, Lia, Allegorico, additional, Maria, Allegri Rossi Beatrice, additional, Anastasia, Alteno, additional, Pia, Amato Maria, additional, Pietro, Annovazzi, additional, Carlo, Antozzi, additional, Lucia, Appendino, additional, Sebastiano, Arena, additional, Viola, Baione, additional, Roberto, Balgera, additional, Valeria, Barcella, additional, Damiano, Baroncini, additional, Caterina, Barrilà, additional, Mario A, Battaglia, additional, Alessandra, Bellacosa, additional, Gianmarco, Bellucci, additional, Roberto, Bergamaschi, additional, Valeria, Bergamaschi, additional, Daiana, Bezzini, additional, Beatrice, Biolzi, additional, Alvino, Bisecco, additional, Simona, Bonavita, additional, Giovanna, Borriello, additional, Chiara, Bosa, additional, Antonio, Bosco, additional, Francesca, Bovis, additional, Marco, Bozzali, additional, Laura, Brambilla, additional, Vincenzo, Brescia Morra, additional, Giampaolo, Brichetto, additional, Maria, Buccafusca, additional, Elisabetta, Bucciantini, additional, Sebastiano, Bucello, additional, Chiara, Buscarinu Maria, additional, Paola, Cabboi Maria, additional, Massimiliano, Calabrese, additional, Francesca, Calabria, additional, Francesca, Caleri, additional, Federico, Camilli, additional, Maria, Caniatti Luisa, additional, Roberto, Cantello, additional, Marco, Capobianco, additional, Ruggero, Capra, additional, Rocco, Capuano, additional, Luca, Carmisciano, additional, Patrizia, Carta, additional, Paola, Cavalla, additional, Grazia, Celani Maria, additional, Maria, Cellerino, additional, Raffaella, Cerqua, additional, Clara, Chisari, additional, Raffaella, Clerici, additional, Marinella, Clerico, additional, Eleonora, Cocco, additional, Gaia, Cola, additional, Giancarlo, Comi, additional, Paolo, Confalonieri, additional, Antonella, Conte, additional, Zaffira, Conti Marta, additional, Christian, Cordano, additional, Susanna, Cordera, additional, Cinzia, Cordioli, additional, Francesco, Corea, additional, Claudio, Correale, additional, Salvatore, Cottone, additional, Francesco, Crescenzo, additional, Erica, Curti, additional, Alessandro, d'Ambrosio, additional, Emanuele, D'Amico, additional, Chiara, Danni Maura, additional, Alessia, d'Arma, additional, Vincenzo, Dattola, additional, Stefano, de Biase, additional, Giovanna, De Luca, additional, Federica, De Mercanti Stefania, additional, Paolo, De Mitri, additional, Nicola, De Rossi, additional, Nicola, De Stefano, additional, Maria, Della Cava Fabio, additional, Marco, Della Cava, additional, Sonia, Di Lemme, additional, Mario, di Napoli, additional, Alessia, Di Sapio, additional, Renato, Docimo, additional, Anna, Dutto, additional, Luana, Evangelista, additional, Salvatore, Fanara, additional, Roberta, Fantozzi, additional, Diana, Ferraro, additional, Teresa, Ferrò Maria, additional, Massimo, Filippi, additional, Cristina, Fioretti, additional, Mario, Fratta, additional, Jessica, Frau, additional, Marzia, Fronza, additional, Roberto, Furlan, additional, Alberto, Gajofatto, additional, Antonio, Gallo, additional, Paolo, Gallo, additional, Claudio, Gasperini, additional, Anna, Ghazaryan, additional, Bruno, Giometto, additional, Francesca, Gobbin, additional, Flora, Govone, additional, Franco, Granella, additional, Erica, Grange, additional, Grazia, Grasso Maria, additional, Luigi ME, Grimaldi, additional, Angelica, Guareschi, additional, Clara, Guaschino, additional, Simone, Guerrieri, additional, Donata, Guidetti, additional, Barbara, Juergenson Ina, additional, Pietro, Iaffaldano, additional, Antonio, Ianniello, additional, Luigi, Iasevoli, additional, Paolo, Immovilli, additional, Daniele, Imperiale, additional, Teresa, Infante Maria, additional, Matilde, Inglese, additional, Rosa, Iodice, additional, Aniello, Iovino, additional, Giovanna, Konrad, additional, Doriana, Landi, additional, Roberta, Lanzillo, additional, Caterina, Lapucci, additional, Luigi, Lavorgna, additional, Rita, L'Episcopo Maria, additional, Serena, Leva, additional, Giuseppe, Liberatore, additional, Marianna, Lo Re, additional, Marco, Longoni, additional, Leonardo, Lopiano, additional, Lorena, Lorefice, additional, Matteo, Lucchini, additional, Giacomo, Lus, additional, Davide, Maimone, additional, Maria, Malentacchi, additional, Giulia, Mallucci, additional, Simona, Malucchi, additional, Rosa, Mancinelli Chiara, additional, Luca, Mancinelli, additional, Paolo, Manganotti, additional, Teresa, Maniscalco Giorgia, additional, Vittorio, Mantero, additional, Sabrina, Marangoni, additional, Damiano, Marastoni, additional, Alessandra, Marfia Girolama, additional, Fabiana, Marinelli, additional, Alessandro, Marti, additional, Filippo, Martinelli Boneschi, additional, Federco, Masserano Zoli, additional, Francesca, Matta, additional, Laura, Mendozzi, additional, Giuseppe, Meucci, additional, Silvia, Miante, additional, Giuseppina, Miele, additional, Eva, Milano, additional, Massimiliano, Mirabella, additional, Rosanna, Missione, additional, Marcello, Moccia, additional, Lucia, Moiola, additional, Sara, Montepietra, additional, Margherita, MontiBragadin, additional, Federico, Montini, additional, Roberta, Motta, additional, Raffaele, Nardone, additional, Gabri, Nicoletti Carolina, additional, Eduardo, Nobile-Orazio, additional, Agostino, Nozzolillo, additional, Marco, Onofrj, additional, Riccardo, Orlandi, additional, Anna, Palmieri, additional, Damiano, Paolicelli, additional, Livia, Pasquali, additional, Fulvio, Pasquin, additional, Luisa, Pastò, additional, Francesco, Patti, additional, Elisabetta, Pedrazzoli, additional, Paola, Perini, additional, Ilaria, Pesci, additional, Maria, Petracca, additional, Alfredo, Petrone, additional, Carlo, Piantadosi, additional, Anna M, Pietroboni, additional, Federica, Pinardi, additional, Marta, Ponzano, additional, Emilio, Portaccio, additional, Mattia, Pozzato, additional, Carlo, Pozzilli, additional, Luca, Prosperini, additional, Alessandra, Protti, additional, Eugenio, Pucci, additional, Marta, Radaelli, additional, Paolo, Ragonese, additional, Sarah, Rasia, additional, Sabrina, Realmuto, additional, Anna, Repice, additional, Eleonora, Rigoni, additional, Teresa, Rilla Maria, additional, Francesca, Rinaldi, additional, Marcello, Romano Calogero, additional, Marco, Ronzoni, additional, Marco, Rovaris, additional, Francesca, Ruscica, additional, Loredana, Sabattini, additional, Giuseppe, Salemi, additional, Marco, Salvetti, additional, Lorenzo, Saraceno, additional, Alessia, Sartori, additional, Arianna, Sartori, additional, Elvira, Sbragia, additional, Cinzia, Scandellari, additional, Ilaria, Scarano Giuditta, additional, Valentina, Scarano, additional, Irene, Schiavetti, additional, Maria, Sessa, additional, Caterina, Sgarito, additional, Grazia, Sibilia, additional, Gabriele, Siciliano, additional, Alessio, Signori, additional, Elisabetta, Signoriello, additional, Leonardo, Sinisi, additional, Francesca, Sireci, additional, Patrizia, Sola, additional, Claudio, Solaro, additional, Pia, Sormani Maria, additional, Stefano, Sotgiu, additional, Maddalena, Sparaco, additional, Laura, Stromillo Maria, additional, Silvia, Strumia, additional, Laura, Susani Emanuela, additional, Giulietta, Tabiadon, additional, Francesco, Teatini, additional, Gioacchino, Tedeschi, additional, Valentina, Tomassini, additional, Simone, Tonietti, additional, Valentina, Torri Clerici, additional, Carla, Tortorella, additional, Simona, Toscano, additional, Rocco, Totaro, additional, Maria, Trojano, additional, Maria, Trotta, additional, Gabriella, Turano, additional, Monica, Ulivelli, additional, Manzo, Valentino, additional, Giovanna, Vaula, additional, Domizia, Vecchio, additional, Marco, Vercellino, additional, Pinuccia, Verrengia Elena, additional, Marika, Vianello, additional, Eleonora, Virgilio, additional, Francesca, Vitetta, additional, Stefano, Vollaro, additional, Mauro, Zaffaroni, additional, Mauro, Zampolini, additional, Roberto, Zarbo Ignazio, additional, Antonio, Zito, additional, and Luigi, Zuliani, additional
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- 2022
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48. Stopping disease-modifying treatments in multiple sclerosis: a meta-analysis with meta-regression
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Gasperini, Claudio, Ruggieri, Serena, Haggiag, Shalom, Prosperini, Luca, and Tortorella, Carla
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Medical Sciences ,FOS: Clinical medicine ,Medicine and Health Sciences ,Neurosciences - Abstract
We aim at conducting a quantitative synthesis (meta-analysis) of the currently available real world evidence on discontinuation of disease-modifying treatments (DMTs) in patients with multiple sclerosis (MS), focusing on platform self-injectable and oral DMTs, i.e. interferon beta, glatiramer acetate, dimethyl fumarate, teriflunomide. We will explore: (1) the event rates for relapses and disability accrual after stopping platform DMTs; (2) the main determinants (moderators) for increased rates of relapse and disability accrual after stopping platform DMTs. We do not include studies about discontinuation of high-efficacy DMTs, i.e. monoclonal antibodies and sphingosine-1-phospate (S1P) receptors modulators whose discontinuation is commonly driven by safety issues and is freqeuntly associated with huge reactivation of disease activity (rebound).
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- 2023
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49. Pregnancy decision-making in women with multiple sclerosis treated with natalizumab: I: Fetal risks
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Portaccio, Emilio, Annovazzi, Pietro, Ghezzi, Angelo, Zaffaroni, Mauro, Moiola, Lucia, Martinelli, Vittorio, Lanzillo, Roberta, Brescia Morra, Vincenzo, Rinaldi, Francesca, Gallo, Paolo, Tortorella, Carla, Paolicelli, Damiano, Pozzilli, Carlo, De Giglio, Laura, Cavalla, Paola, Cocco, Eleonora, Marrosu, Maria Giovanna, Patti, Francesco, Solaro, Claudio, Bellantonio, Paolo, Uccelli, Antonio, Laroni, Alice, Pastò, Luisa, Giannini, Marta, Trojano, Maria, Comi, Giancarlo, and Amato, Maria Pia
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- 2018
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50. Pregnancy decision-making in women with multiple sclerosis treated with natalizumab: II: Maternal risks
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Portaccio, Emilio, Moiola, Lucia, Martinelli, Vittorio, Annovazzi, Pietro, Ghezzi, Angelo, Zaffaroni, Mauro, Lanzillo, Roberta, Brescia Morra, Vincenzo, Rinaldi, Francesca, Gallo, Paolo, Tortorella, Carla, Paolicelli, Damiano, Pozzilli, Carlo, De Giglio, Laura, Cavalla, Paola, Cocco, Eleonora, Marrosu, Maria Giovanna, Solaro, Claudio, Uccelli, Antonio, Laroni, Alice, Pastò, Luisa, Giannini, Marta, Trojano, Maria, Comi, Giancarlo, and Amato, Maria Pia
- Published
- 2018
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