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282 results on '"Torrisi, Sebastiano"'

1. Dopamine D3 Receptor, Cognition and Cognitive Dysfunctions in Neuropsychiatric Disorders: From the Bench to the Bedside

Author

Torrisi, Sebastiano Alfio, Geraci, Federica, Contarini, Gabriella, Salomone, Salomone, Drago, Filippo, Leggio, Gian Marco, Geyer, Mark A., Series Editor, Marsden, Charles A., Series Editor, Ellenbroek, Bart A., Series Editor, Barnes, Thomas R. E., Series Editor, Andersen, Susan L., Series Editor, Paulus, Martin P., Series Editor, Olivier, Jocelien, Series Editor, Boileau, Isabelle, editor, and Collo, Ginetta, editor

Published
2023
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5. Quantum-inspired Minimum Distance Classification in Biomedical Context

Author

Sergioli, Giuseppe, Russo, Giorgio, Santucci, Enrica, Stefano, Alessandro, Torrisi, Sebastiano Emanuele, Palmucci, Stefano, Vancheri, Carlo, and Giuntini, Roberto

Subjects
Quantum Physics
Abstract

We face the problem of pattern classification by proposing a quantum-inspired version of the widely used minimum distance classifier (i.e. the Nearest Mean Classifier (NMC)) already introduced in [31,33,28,27] and by applying this quantum-inspired classifier in a biomedical context. In particular, we show and compare the NMC and our quantum model performance to solve a problem related to classify the probability of survival for patients affected by idiopathic pulmonary fibrosis (IPF).

Published
2018

7. Blockade of dopamine D3 receptors improves hippocampal synaptic function and rescues age‐related cognitive phenotype.

Author

Tropea, Maria Rosaria, Melone, Marcello, Li Puma, Domenica Donatella, Vacanti, Valeria, Aceto, Giuseppe, Bandiera, Bruno, Trovato, Roberta Carmela, Torrisi, Sebastiano Alfio, Leggio, Gian Marco, Palmeri, Agostino, D'Ascenzo, Marcello, Conti, Fiorenzo, Grassi, Claudio, and Puzzo, Daniela

Abstract

Dopamine D3 receptors (D3Rs) modulate neuronal activity in several brain regions including the hippocampus. Although previous studies reported that blocking D3Rs exerts pro‐cognitive effects, their involvement in hippocampal synaptic function and memory in the healthy and aged brain has not been thoroughly investigated. We demonstrated that in adult wild type (WT) mice, D3R pharmacological blockade or genetic deletion as in D3 knock out (KO) mice, converted the weak form of long‐term potentiation (LTP1) into the stronger long‐lasting LTP (LTP2) via the cAMP/PKA pathway, and allowed the formation of long‐term memory. D3R effects were mainly mediated by post‐synaptic mechanisms as their blockade enhanced basal synaptic transmission (BST), AMPAR‐mediated currents, mEPSC amplitude, and the expression of the post‐synaptic proteins PSD‐95, phospho(p)GluA1 and p‐CREB. Consistently, electron microscopy revealed a prevalent expression of D3Rs in post‐synaptic dendrites. Interestingly, with age, D3Rs decreased in axon terminals while maintaining their levels in post‐synaptic dendrites. Indeed, in aged WT mice, blocking D3Rs reversed the impairment of LTP, BST, memory, post‐synaptic protein expression, and PSD length. Notably, aged D3‐KO mice did not exhibit synaptic and memory deficits. In conclusion, we demonstrated the fundamental role of D3Rs in hippocampal synaptic function and memory, and their potential as a therapeutic target to counteract the age‐related hippocampal cognitive decline. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Pharmacological enhancement of cholinergic neurotransmission alleviates neuroinflammation and improves functional outcomes in a triple transgenic mouse model of Alzheimer’s disease

Author

Munafò, Antonio, primary, Cantone, Anna Flavia, additional, Di Benedetto, Giulia, additional, Torrisi, Sebastiano Alfio, additional, Burgaletto, Chiara, additional, Bellanca, Carlo Maria, additional, Gaudio, Gabriella, additional, Broggi, Giuseppe, additional, Caltabiano, Rosario, additional, Leggio, Gian Marco, additional, Bernardini, Renato, additional, and Cantarella, Giuseppina, additional

Published
2024
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13. Increased monocyte count and red cell distribution width as prognostic biomarkers in patients with Idiopathic Pulmonary Fibrosis

Author

Karampitsakos, Theodoros, Torrisi, Sebastiano, Antoniou, Katerina, Manali, Effrosyni, Korbila, Ioanna, Papaioannou, Ourania, Sampsonas, Fotios, Katsaras, Matthaios, Vasarmidi, Eirini, Papakosta, Despoina, Domvri, Kalliopi, Fouka, Eva, Organtzis, Ioannis, Daniil, Zoe, Dimeas, Ilias, Kirgou, Paraskevi, Gourgoulianis, Konstantinos I., Papanikolaou, Ilias C., Markopoulou, Katerina, Kounti, Georgia, Tsapakidou, Eirini, Papadopoulou, Efthymia, Tatsis, Konstantinos, Gogali, Athena, Kostikas, Konstantinos, Tzilas, Vasilios, Chrysikos, Serafeim, Papiris, Spyridon, Bouros, Demosthenes, Kreuter, Michael, and Tzouvelekis, Argyrios

Published
2021
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18. Anthocyanin-rich fruits and mental health outcomes in an Italian cohort

Author

Micek, Agnieszka, Owczarek, Marcin, Jurek, Joanna, Guerrera, Ida, Torrisi, Sebastiano Alfio, Grosso, Giuseppe, Alshatwi, Ali A., and Godos, Justyna

Subjects
Soil Science, Plant Science, Horticulture, Agronomy and Crop Science, Biochemistry, Food Science
Abstract

BACKGROUND: Evidence suggests that diets rich in flavonoids affect human health. Among flavonoids, anthocyanins have been demonstrated to exert beneficial effects toward brain through modulation of neuroinflammation, neurogenesis, neuronal signaling and by modulating gut microbiota. OBJECTIVE: This study aimed to investigate the association between consumption of anthocyanin-rich fruits (strawberries, berries, cherries, prickly pears, grapes, blood oranges) and mental health in an Italian cohort study. METHODS: Dietary information was collected using a validated food frequency questionnaire. Mental health outcomes were assessed using the Pittsburgh Sleep Quality Index (PSQI), the Perceived Stress Scale (PSS), the 10-item Center for the Epidemiological Studies of Depression Short Form (CES-D-10) as a screening tool for sleep quality, perceived stress and depressive symptoms, respectively. RESULTS: A significant inverse association between higher anthocyanin-rich fruits intake and occurrence of poor sleep quality, high perceived stress, and depressive symptoms was found. In the most adjusted model, individuals in the highest tertile of anthocyanin-rich fruits were less likely to have poor sleep quality (OR = 0.63, 95% CI: 0.47–0.86), high perceived stress (OR = 0.68, 95% CI: 0.51–0.92), and depressive symptoms (OR = 0.67, 95% CI: 0.49–0.90). CONCLUSIONS: Diets including fruits rich in anthocyanins may result in positive mental health outcomes.

Published
2022

19. Antacid therapy in idiopathic pulmonary fibrosis: more questions than answers?

Author

Albera, Carlo, Antoniou, Katerina M., Altinisik, Goksel, Bendstrup, Elisabeth, Bondue, Benjamin, Borie, Raphael, Brown, Kevin K., Camus, Philippe, Castillo, Diego, Collard, Harold R., Cottin, Vincent, Crimi, Nunzio, Ferrara, Giovanni, Fischer, Aryeh, Gauldie, Jack, Geiser, Thomas, Guenther, Andreas, Hambly, Nathan, Hansell, David M., Harari, Sergio, Jones, Mark G., Keane, Michael, Ley, Brett, Maher, Toby M., Molina-Molina, Maria, Palmucci, Stefano, Poletti, Venerino, Prasse, Antje, Rottoli, Paola, Spagnolo, Paolo, Sterclova, Martina, Torrisi, Sebastiano, Tsitoura, Eliza, Vasakova, Martina, Walsh, Simon L., Wijsenbeek, Marlies S., Wuyts, Wim A., Johannson, Kerri A, Strâmbu, Irina, Ravaglia, Claudia, Grutters, Jan C, Valenzuela, Claudia, Mogulkoc, Nesrin, Luppi, Fabrizio, Richeldi, Luca, Wells, Athol U, Vancheri, Carlo, and Kreuter, Michael

Published
2017
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23. Assessment of Lung Cancer Development in Idiopathic Pulmonary Fibrosis Patients Using Quantitative High-Resolution Computed Tomography: A Retrospective Analysis

Author

Palmucci, Stefano, Torrisi, Sebastiano E., Falsaperla, Daniele, Stefano, Alessandro, Torcitto, Alfredo G., Russo, Giorgio, Pavone, Mauro, Vancheri, Ada, Mauro, Letizia A., Grassedonio, Emanuele, Sambataro, Gianluca, Puglisi, Silvia, Piciucchi, Sara, Tomassetti, Sara, Poletti, Venerino, Basile, Antonio, and Vancheri, Carlo

Published
2020
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24. The Role of Dopamine D3 Receptors, Dysbindin, and Their Functional Interaction in the Expression of Key Genes for Neuroplasticity and Neuroinflammation in the Mouse Brain

Author

Rivi, Veronica, primary, Benatti, Cristina, additional, Blom, Joan M. C., additional, Pani, Luca, additional, Brunello, Nicoletta, additional, Drago, Filippo, additional, Papaleo, Francesco, additional, Caraci, Filippo, additional, Geraci, Federica, additional, Torrisi, Sebastiano Alfio, additional, Leggio, Gian Marco, additional, and Tascedda, Fabio, additional

Published
2023
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27. Polyphenol-Rich Beverages and Mental Health Outcomes

Author

Micek, Agnieszka, primary, Jurek, Joanna, additional, Owczarek, Marcin, additional, Guerrera, Ida, additional, Torrisi, Sebastiano Alfio, additional, Castellano, Sabrina, additional, Grosso, Giuseppe, additional, Alshatwi, Ali A., additional, and Godos, Justyna, additional

Published
2023
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30. Prenatal stress induces a depressive-like phenotype in adolescent rats: The key role of TGF-β1 pathway

Author

Fidilio, Annamaria, primary, Grasso, Margherita, additional, Caruso, Giuseppe, additional, Musso, Nicolò, additional, Begni, Veronica, additional, Privitera, Anna, additional, Torrisi, Sebastiano Alfio, additional, Campolongo, Patrizia, additional, Schiavone, Stefania, additional, Tascedda, Fabio, additional, Leggio, Gian Marco, additional, Drago, Filippo, additional, Riva, Marco Andrea, additional, and Caraci, Filippo, additional

Published
2022
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33. Improvement in the management of chronic obstructive pulmonary disease following a clinical educational program: results from a prospective cohort study in the Sicilian general practice setting

Author

Ferrara, Rosarita, Ientile, Valentina, Piccinni, Carlo, Pasqua, Alessandro, Pecchioli, Serena, Fontana, Andrea, Alecci, Umberto, Scoglio, Riccardo, Magliozzo, Francesco, Torrisi, Sebastiano Emanuele, Vancheri, Carlo, Vitulo, Patrizio, Fantaci, Giovanna, Ferrajolo, Carmen, Cazzola, Mario, Cricelli, Claudio, Caputi, Achille Patrizio, and Trifirò, Gianluca

Published
2018
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35. Molecular Effects of Chronic Exposure to Palmitate in Intestinal Organoids: A New Model to Study Obesity and Diabetes

Author

Filippello, Agnese, primary, Di Mauro, Stefania, additional, Scamporrino, Alessandra, additional, Torrisi, Sebastiano Alfio, additional, Leggio, Gian Marco, additional, Di Pino, Antonino, additional, Scicali, Roberto, additional, Di Marco, Maurizio, additional, Malaguarnera, Roberta, additional, Purrello, Francesco, additional, and Piro, Salvatore, additional

Published
2022
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36. Immunomodulatory treatment in unclassifiable interstitial lung disease: A retrospective study of treatment response.

Author

Hyldgaard, Charlotte, Torrisi, Sebastiano, Kronborg Brix‐White, Sissel, Prior, Thomas Skovhus, Ganter, Claudia, Bendstrup, Elisabeth, and Kreuter, Michael

Subjects
*INTERSTITIAL lung diseases, *VITAL capacity (Respiration), *PROPENSITY score matching, *CARBON monoxide
Abstract

Background and Objective: The optimal management of unclassifiable Interstitial lung disease (ILD) remains a challenge. The aim of this study was to describe pulmonary function trajectories for patients treated with immunomodulatory therapy and for untreated patients. Methods: Clinical information and treatment data were obtained retrospectively at two ILD centres. Pulmonary function data were analysed using (1) mixed effects linear regression models with and without clinical covariates and (2) propensity score matching using gender, age, physiology (GAP) stage, smoking and presence of ground glass opacities. Results: Sixty‐five percent of the 249 patients included received corticosteroids and/or other immunomodulators. Treated patients had lower forced vital capacity (FVC) (72% vs. 83% predicted) and diffusing capacity for carbon monoxide (DLco) (44% vs. 60% predicted). In mixed effects linear regression, the adjusted change in FVC was −0.22%, [−0.34; −0.11], and −0.15% [−0.28;‐0.012] for DLco. The difference in pulmonary function decline between treated and untreated patients was insignificant, −0.082% per month, [−0.28; 0.11], p = 0.10 for FVC and −0.14% per month, [−0.36; 0.079], p = 0.15, for DLco. In propensity score matched analysis, the difference in change in FVC was 0.039% per month, p = 0.12, and for DLco, 0.0085% per month, p = 0.7. Conclusion: The pulmonary function trajectories for treated and untreated patients were parallel, despite treated patients having more severe disease at baseline. The persisting differences between the groups suggest no overall effect, although improvement or stabilization may be seen in some patients. Prospective studies are needed to define subsets of patients with unclassifiable interstitial lung disease and their optimal management. Patients with unclassifiable interstitial lung disease who received immunomodulatory therapy had similar pulmonary function trajectories as patients who did not receive therapy despite more severe disease at baseline in treated patients. This suggests a lack of overall improvement, although immunomodulatory therapy may have effect in a subgroup of patients. [ABSTRACT FROM AUTHOR]

Published
2023
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37. A New Method for the Assessment of Myalgia in Interstitial Lung Disease: Association with Positivity for Myositis-Specific and Myositis-Associated Antibodies

Author

Sambataro, Gianluca, primary, Ferrara, Chiara Alfia, additional, Spadaro, Carla, additional, Torrisi, Sebastiano Emanuele, additional, Vignigni, Giovanna, additional, Vancheri, Ada, additional, Muscato, Giuseppe, additional, Del Papa, Nicoletta, additional, Colaci, Michele, additional, Malatino, Lorenzo, additional, Palmucci, Stefano, additional, Cavagna, Lorenzo, additional, Zanframundo, Giovanni, additional, Ferro, Francesco, additional, Baldini, Chiara, additional, Sambataro, Domenico, additional, and Vancheri, Carlo, additional

Published
2022
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39. Antioxidant Activity of Fluoxetine and Vortioxetine in a Non-Transgenic Animal Model of Alzheimer’s Disease

Author

Caruso, Giuseppe, primary, Grasso, Margherita, additional, Fidilio, Annamaria, additional, Torrisi, Sebastiano Alfio, additional, Musso, Nicolò, additional, Geraci, Federica, additional, Tropea, Maria Rosaria, additional, Privitera, Anna, additional, Tascedda, Fabio, additional, Puzzo, Daniela, additional, Salomone, Salvatore, additional, Drago, Filippo, additional, Leggio, Gian Marco, additional, and Caraci, Filippo, additional

Published
2021
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42. The antineoplastic drug flavopiridol reverses memory impairment induced by Amyloid-ß1–42 oligomers in mice

Author

Leggio, Gian Marco, Catania, Maria Vincenza, Puzzo, Daniela, Spatuzza, Michela, Pellitteri, Rosalia, Gulisano, Walter, Torrisi, Sebastiano Alfio, Giurdanella, Giovanni, Piazza, Cateno, Impellizzeri, Agata Rita, Gozzo, Lucia, Navarria, Andrea, Bucolo, Claudio, Nicoletti, Ferdinando, Palmeri, Agostino, Salomone, Salvatore, Copani, Agata, Caraci, Filippo, and Drago, Filippo

Published
2016
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45. High Glucose Exposure Impairs L-Cell Differentiation in Intestinal Organoids: Molecular Mechanisms and Clinical Implications

Author

Filippello, Agnese, primary, Di Mauro, Stefania, additional, Scamporrino, Alessandra, additional, Malaguarnera, Roberta, additional, Torrisi, Sebastiano Alfio, additional, Leggio, Gian Marco, additional, Di Pino, Antonino, additional, Scicali, Roberto, additional, Purrello, Francesco, additional, and Piro, Salvatore, additional

Published
2021
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46. Additional file 1 of Increased monocyte count and red cell distribution width as prognostic biomarkers in patients with Idiopathic Pulmonary Fibrosis

Author

Karampitsakos, Theodoros, Torrisi, Sebastiano, Antoniou, Katerina, Manali, Effrosyni, Korbila, Ioanna, Papaioannou, Ourania, Sampsonas, Fotios, Katsaras, Matthaios, Vasarmidi, Eirini, Papakosta, Despoina, Domvri, Kalliopi, Fouka, Eva, Organtzis, Ioannis, Daniil, Zoe, Dimeas, Ilias, Kirgou, Paraskevi, Gourgoulianis, Konstantinos I., Papanikolaou, Ilias C., Markopoulou, Katerina, Kounti, Georgia, Tsapakidou, Eirini, Papadopoulou, Efthymia, Tatsis, Konstantinos, Gogali, Athena, Kostikas, Konstantinos, Tzilas, Vasilios, Chrysikos, Serafeim, Papiris, Spyridon, Demosthenes Bouros, Kreuter, Michael, and Tzouvelekis, Argyrios

Abstract

Additional file1: Additional Tables and Figure.

Published
2021
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47. Patient-reported outcomes and patient-reported outcome measures in interstitial lung disease: where to go from here?

Author

Kalluri, M, Luppi, F, Vancheri, A, Vancheri, C, Balestro, E, Varone, F, Mogulkoc, N, Cacopardo, G, Bargagli, E, Renzoni, E, Torrisi, S, Calvello, M, Libra, A, Pavone, M, Bonella, F, Cottin, V, Valenzuela, C, Wijsenbeek, M, Bendstrup, E, Kalluri, Meena, Luppi, Fabrizio, Vancheri, Ada, Vancheri, Carlo, Balestro, Elisabetta, Varone, Francesco, Mogulkoc, Nesrin, Cacopardo, Giulia, Bargagli, Elena, Renzoni, Elizabeth, Torrisi, Sebastiano, Calvello, Mariarosaria, Libra, Alessandro, Pavone, Mauro, Bonella, Francesco, Cottin, Vincent, Valenzuela, Claudia, Wijsenbeek, Marlies, Bendstrup, Elisabeth, Kalluri, M, Luppi, F, Vancheri, A, Vancheri, C, Balestro, E, Varone, F, Mogulkoc, N, Cacopardo, G, Bargagli, E, Renzoni, E, Torrisi, S, Calvello, M, Libra, A, Pavone, M, Bonella, F, Cottin, V, Valenzuela, C, Wijsenbeek, M, Bendstrup, E, Kalluri, Meena, Luppi, Fabrizio, Vancheri, Ada, Vancheri, Carlo, Balestro, Elisabetta, Varone, Francesco, Mogulkoc, Nesrin, Cacopardo, Giulia, Bargagli, Elena, Renzoni, Elizabeth, Torrisi, Sebastiano, Calvello, Mariarosaria, Libra, Alessandro, Pavone, Mauro, Bonella, Francesco, Cottin, Vincent, Valenzuela, Claudia, Wijsenbeek, Marlies, and Bendstrup, Elisabeth

Abstract

Patient-reported outcome measures (PROMs), tools to assess patient self-report of health status, are now increasingly used in research, care and policymaking. While there are two well-developed disease-specific PROMs for interstitial lung diseases (ILD) and idiopathic pulmonary fibrosis (IPF), many unmet and urgent needs remain. In December 2019, 64 international ILD experts convened in Erice, Italy to deliberate on many topics, including PROMs in ILD. This review summarises the history of PROMs in ILD, shortcomings of the existing tools, challenges of development, validation and implementation of their use in clinical trials, and the discussion held during the meeting. Development of disease-specific PROMs for ILD including IPF with robust methodology and validation in concordance with guidance from regulatory authorities have increased user confidence in PROMs. Minimal clinically important difference for bidirectional changes may need to be developed. Cross-cultural validation and linguistic adaptations are necessary in addition to robust psychometric properties for effective PROM use in multinational clinical trials. PROM burden of use should be reduced through appropriate use of digital technologies and computerised adaptive testing. Active patient engagement in all stages from development, testing, choosing and implementation of PROMs can help improve probability of success and further growth.

Published
2021

48. Patient-reported outcomes and patient-reported outcome measures in interstitial lung disease:Where to go from here?

Author

Kalluri, Meena, Luppi, Fabrizio, Vancheri, Ada, Vancheri, Carlo, Balestro, Elisabetta, Varone, Francesco, Mogulkoc, Nesrin, Cacopardo, Giulia, Bargagli, Elena, Renzoni, Elisabetta, Torrisi, Sebastiano, Calvello, Mariarosaria, Libra, Alessandro, Pavone, Mauro, Bonella, Francesco, Cottin, Vincent, Valenzuela, Claudia, Wijsenbeek, Marlies, Bendstrup, Elisabeth, Kalluri, Meena, Luppi, Fabrizio, Vancheri, Ada, Vancheri, Carlo, Balestro, Elisabetta, Varone, Francesco, Mogulkoc, Nesrin, Cacopardo, Giulia, Bargagli, Elena, Renzoni, Elisabetta, Torrisi, Sebastiano, Calvello, Mariarosaria, Libra, Alessandro, Pavone, Mauro, Bonella, Francesco, Cottin, Vincent, Valenzuela, Claudia, Wijsenbeek, Marlies, and Bendstrup, Elisabeth

Abstract

Patient-reported outcome measures (PROMs), tools to assess patient self-report of health status, are now increasingly used in research, care and policymaking. While there are two well-developed disease-specific PROMs for interstitial lung diseases (ILD) and idiopathic pulmonary fibrosis (IPF), many unmet and urgent needs remain. In December 2019, 64 international ILD experts convened in Erice, Italy to deliberate on many topics, including PROMs in ILD. This review summarises the history of PROMs in ILD, shortcomings of the existing tools, challenges of development, validation and implementation of their use in clinical trials, and the discussion held during the meeting. Development of disease-specific PROMs for ILD including IPF with robust methodology and validation in concordance with guidance from regulatory authorities have increased user confidence in PROMs. Minimal clinically important difference for bidirectional changes may need to be developed. Cross-cultural validation and linguistic adaptations are necessary in addition to robust psychometric properties for effective PROM use in multinational clinical trials. PROM burden of use should be reduced through appropriate use of digital technologies and computerised adaptive testing. Active patient engagement in all stages from development, testing, choosing and implementation of PROMs can help improve probability of success and further growth.

Published
2021

50. Patient-reported outcomes and patient-reported outcome measures in interstitial lung disease: where to go from here?

Author

Kalluri, Meena, primary, Luppi, Fabrizio, additional, Vancheri, Ada, additional, Vancheri, Carlo, additional, Balestro, Elisabetta, additional, Varone, Francesco, additional, Mogulkoc, Nesrin, additional, Cacopardo, Giulia, additional, Bargagli, Elena, additional, Renzoni, Elisabetta, additional, Torrisi, Sebastiano, additional, Calvello, Mariarosaria, additional, Libra, Alessandro, additional, Pavone, Mauro, additional, Bonella, Francesco, additional, Cottin, Vincent, additional, Valenzuela, Claudia, additional, Wijsenbeek, Marlies, additional, and Bendstrup, Elisabeth, additional

Published
2021
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