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1. Comparative outcomes of aortobifemoral bypass with or without previous endovascular kissing stenting of the aortoiliac bifurcation

Author

Ancetti, Stefano, Attisani, Luca, Berchiolli, Raffaella, Bertoglio, Luca, Bissacco, Daniele, Calvagna, Cristiano, Chiesa, Roberto, Colacchio, Chiara, D'Andrea, Alessia, Gallitto, Enrico, Grando, Beatrice, Grego, Franco, Griselli, Filippo, Grosso, Lorenzo, Gorgatti, Filippo, Mauri, Francesca, Melissano, Germano, Melloni, Andrea, Mezzetto, Luca, Miglioranza, Elena, Piazza, Michele, Santagata, Annamaria, Settembrini, Alberto, Torri, Lorenzo, Tozzi, Matteo, Lepidi, Sandro, Mastrorilli, Davide, Antonello, Michele, Kahlberg, Andrea, Frigatti, Paolo, Piffaretti, Gabriele, Bonardelli, Stefano, Gargiulo, Mauro, Veraldi, Gian Franco, Perkmann, Reinhold, Troisi, Nicola, Trimarchi, Santi, Bellosta, Raffaello, and D'Oria, Mario

Published
2024
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2. Radiomics and artificial intelligence analysis of CT data for the identification of prognostic features in multiple myeloma

Author

Schenonea, Daniela, Lai, Rita, Cea, Michele, Rossi, Federica, Torri, Lorenzo, Bignotti, Bianca, Succio, Giulia, Gualco, Stefano, Conte, Alessio, Dominietto, Alida, Massone, Anna Maria, Piana, Michele, Campi, Cristina, Frassoni, Francesco, Sambuceti, Gianmario, and Tagliafico, Alberto Stefano

Subjects
Quantitative Biology - Tissues and Organs, 92C55, 68T10, 68U10
Abstract

Multiple Myeloma (MM) is a blood cancer implying bone marrow involvement, renal damages and osteolytic lesions. The skeleton involvement of MM is at the core of the present paper, exploiting radiomics and artificial intelligence to identify image-based biomarkers for MM. Preliminary results show that MM is associated to an extension of the intrabone volume for the whole body and that machine learning can identify CT image features mostly correlating with the disease evolution. This computational approach allows an automatic stratification of MM patients relying of these biomarkers and the formulation of a prognostic procedure for determining the disease follow-up.

Published
2020

5. Comparative outcomes of aortobifemoral bypass with or without previous endovascular kissing stenting of the aortoiliac bifurcation

Author

Lepidi, Sandro, primary, Mastrorilli, Davide, additional, Antonello, Michele, additional, Kahlberg, Andrea, additional, Frigatti, Paolo, additional, Piffaretti, Gabriele, additional, Bonardelli, Stefano, additional, Gargiulo, Mauro, additional, Veraldi, Gian Franco, additional, Perkmann, Reinhold, additional, Troisi, Nicola, additional, Trimarchi, Santi, additional, Bellosta, Raffaello, additional, D'Oria, Mario, additional, Ancetti, Stefano, additional, Attisani, Luca, additional, Berchiolli, Raffaella, additional, Bertoglio, Luca, additional, Bissacco, Daniele, additional, Calvagna, Cristiano, additional, Chiesa, Roberto, additional, Colacchio, Chiara, additional, D'Andrea, Alessia, additional, Gallitto, Enrico, additional, Grando, Beatrice, additional, Grego, Franco, additional, Griselli, Filippo, additional, Grosso, Lorenzo, additional, Gorgatti, Filippo, additional, Mauri, Francesca, additional, Melissano, Germano, additional, Melloni, Andrea, additional, Mezzetto, Luca, additional, Miglioranza, Elena, additional, Piazza, Michele, additional, Santagata, Annamaria, additional, Settembrini, Alberto, additional, Torri, Lorenzo, additional, and Tozzi, Matteo, additional

Published
2024
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10. Editor's Choice – RANDOMisation Screening for Drug coated or Drug Eluting Device Randomised Trials Among Patients Undergoing Endovascular FemorOPopliteal Procedures (RANDOM-STOP study)

Author

Stavroulakis, Konstantinos, primary, Katsogridakis, Emmanuel, additional, Torsello, Giovanni, additional, Zayed, Hany, additional, van Herzeele, Isabelle, additional, Coscas, Raphael, additional, Nasr, Bahaa, additional, Gonzalez, Teresa Martin, additional, Troisi, Nicola, additional, Saratzis, Athanasios, additional, Bohnert, Ambre, additional, Martin-Gonzalez, Teresa, additional, Torsello, Giovanni B., additional, Wichmann, Katrin, additional, Cardona, Yamel Gloria, additional, Stavroulakis, Christiane, additional, Stavroulakis, Konstantinos, additional, Tsilimparis, Nikolaos, additional, Konstantinou, Nikolaos, additional, Croo, Alexander, additional, Jacobs, Karen, additional, Pecceu, Stefanie, additional, Van Langenhove, Karen, additional, Mercier, Lucie, additional, Simonte, Gioele, additional, Terpin, Andrea Maria, additional, Isernia, Giacomo, additional, Furlan, Federico, additional, Frigatti, Paolo, additional, Canovaro, Francesco, additional, Torri, Lorenzo, additional, D'Oria, Mario, additional, Lepidi, Sandro, additional, Magalhães, Tiago, additional, Pedro, Luís Mendes, additional, Marone, Enrico Maria, additional, Marazzi, Giulia, additional, Rinaldi, Luigi Federico, additional, Thulasidasan, Narayanan, additional, Benton, Lily, additional, Gregory, Mark, additional, Asciutto, Giuseppe, additional, Korosoglou, Grigorios, additional, and Torsello, Giovanni Federico, additional

Published
2023
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14. [18F]-Fludeoxyglucose Positron Emission Tomography/Computed Tomography with Radiomics Analysis in Patients Undergoing Aortic In-Situ Reconstruction with Cryopreserved Allografts

Author

Berchiolli, Raffaella, primary, Torri, Lorenzo, additional, Bertagna, Giulia, additional, Canovaro, Francesco, additional, Zanca, Roberta, additional, Bartoli, Francesco, additional, Mocellin, Davide Maria, additional, Ferrari, Mauro, additional, Erba, Paola Anna, additional, and Troisi, Nicola, additional

Published
2022
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17. Myeloma Spine and Bone Damage Score (MSBDS) on Whole-Body Computed Tomography (WBCT): Multiple Reader Agreement in a Multicenter Reliability Study

Author

Tagliafico, Alberto Stefano, primary, Valle, Clarissa, additional, Bonaffini, Pietro Andrea, additional, Attieh, Ali, additional, Bauckneht, Matteo, additional, Belgioia, Liliana, additional, Bignotti, Bianca, additional, Brunetti, Nicole, additional, Bonsignore, Alessandro, additional, Capaccio, Enrico, additional, De Giorgis, Sara, additional, Garlaschi, Alessandro, additional, Morbelli, Silvia, additional, Rossi, Federica, additional, Torri, Lorenzo, additional, Caprioli, Simone, additional, Tosto, Simona, additional, Cea, Michele, additional, and Dominietto, Alida, additional

Published
2022
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21. Radiomics and Artificial Intelligence for Outcome Prediction in Multiple Myeloma Patients Undergoing Autologous Transplantation: A Feasibility Study with CT Data

Author

Schenone, Daniela, primary, Dominietto, Alida, additional, Campi, Cristina, additional, Frassoni, Francesco, additional, Cea, Michele, additional, Aquino, Sara, additional, Angelucci, Emanuele, additional, Rossi, Federica, additional, Torri, Lorenzo, additional, Bignotti, Bianca, additional, Tagliafico, Alberto Stefano, additional, and Piana, Michele, additional

Published
2021
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23. CT-derived relationship between low relative muscle mass and bone damage in patients with multiple myeloma undergoing stem cells transplantation.

Author

Tagliafico, Alberto Stefano, Rossi, Federica, Bignotti, Bianca, Torri, Lorenzo, Bonsignore, Alessandro, Belgioia, Liliana, and Domineitto, Alida

Subjects
STEM cell transplantation, MUSCLE mass, MULTIPLE myeloma, PROGRESSION-free survival, ONE-way analysis of variance, CANCER prognosis, INSTITUTIONAL review boards
Abstract

Sarcopenia or low muscle mass is related to worse prognosis in cancer patients. We investigated whether muscle mass is related to bone damage on CT in patients with multiple myeloma (MM). Approval from the institutional review board was obtained. N = 74 consecutive patients (mean age, 60.8 years ± 9.24 [standard deviation]; range, 36–89 years) for MM who underwent transplant were included. Sarcopenia cut-off points defined as skeletal muscle index (SMI) used were<41 cm2/m2. To assess bone damage in MM the MSBDS (myeloma spine and bone damage score) was used. One-way analysis of variance and the X2 test were used. Kaplan–Meier analysis was performed to generate progression and survival curves according to SMI and MSBDS. The testing level was set at 0.05. The median SMI was 47.1 ± 14.2 and according to SMI 18/74 (24%) had sarcopenia which was more prevalent in females (p.001). A strong and significant association between patients with low muscle mass and elevated bone damage (24/74, 32.4%) and patients with normal/non-low muscle mass low bone damage (30/74, 40.5%) was present. Multiple Logistic regression did not show any significant relationship or confounding influence among SMI and MSBDS regarding sex (p.127), cytogenetic status (p.457), staging (p.756) and relapse (.126). Neither SMI nor MSBDS resulted significantly related to overall survival as shown in Kaplan–Meier analysis. Sarcopenia and bone damage affected MM patients undergoing stem cell transplantation and are significantly associated. Quantitative measurement of sarcopenia and bone damage on CT resulted present in MM patients undergoing stem cell transplantation and are significantly associated. [ABSTRACT FROM AUTHOR]

Published
2022
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25. Radiomics and artificial intelligence analysis of CT data for the identification of prognostic features in multiple myeloma

Author

Schenone, Daniela, primary, Lai, Rita, additional, Cea, Michele, additional, Rossi, Federica, additional, Torri, Lorenzo, additional, Bignotti, Bianca, additional, Succio, Giulia, additional, Gualco, Stefano, additional, Conte, Alessio, additional, Dominietto, Alida, additional, Massone, Anna Maria, additional, Piana, Michele, additional, Campi, Cristina, additional, Frassoni, Francesco, additional, Sambuceti, Gianmario, additional, and Tagliafico, Alberto S., additional

Published
2020
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26. Radiomics and artificial intelligence analysis of CT data for the identification of prognostic features in multiple myeloma

Author

Hahn, Horst K., Mazurowski, Maciej A., Schenone, Daniela, Lai, Rita, Cea, Michele, Rossi, Federica, Torri, Lorenzo, Bignotti, Bianca, Succio, Giulia, Gualco, Stefano, Conte, Alessio, Dominietto, Alida, Massone, Anna Maria, Piana, Michele, Campi, Cristina, Frassoni, Francesco, Sambuceti, Gianmario, and Tagliafico, Alberto Stefano

Published
2020
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27. Early and Midterm Outcomes of Endovascular Aneurysm Repair With Zenith Alpha Abdominal Stent-Graft: Results From a Multicenter Retrospective Tuscany Registry

Author

Troisi, Nicola, Pulli, Raffaele, Donato, Gianmarco de, Adami, Daniele, Bertagna, Giulia, Michelagnoli, Stefano, Berchiolli, Raffaella, Canovaro, Francesco, Torri, Lorenzo, Pratesi, Carlo, Fargion, Aaron, Speziali, Sara, Di Domenico, Rossella, Petroni, Rachele, Palasciano, Giancarlo, Pasqui, Edoardo, Galzerano, Giuseppe, Molino, Cecilia, Giuseppe, Anzaldi Manfredi, Invernizzi, Claudio, Loschiavo, Vincenzo, Chisci, Emiliano, Caneva, Patrizia Dalla, Ercolini, Leonardo, Lazzeri, Elisa, Filippi, Federico, and Panzano, Claudia

Abstract

Purpose: Zenith Alpha Abdominal (Cook Medical, Bloomington, IN, USA) is one of the new-generation low-profile stent-grafts with demonstrated satisfactory early and midterm clinical outcomes for endovascular treatment of abdominal aortic aneurysms (AAAs). The aim was to evaluate early and midterm results of this device in the framework of a multicenter regional retrospective registry, with the analysis of morphological factors affecting outcomes, including different limb configurations.Materials and methods: Between January 2016 and November 2021, 202 patients with AAA underwent elective endovascular aneurysm repair (EVAR) with implantation of a Zenith Alpha Abdominal in 7 centers. Early (30 day) outcomes in terms of technical and clinical success were assessed. Estimated 5 year outcomes were evaluated in terms of survival, freedom from type I/III endoleak, freedom from surgical conversion, freedom from limb graft occlusion, freedom from any device-related reintervention, and graft infection evaluation by life-table analysis (Kaplan–Meier test). A comparative analysis between different limb configurations (Zenith Spiral Z AAA iliac legs, codes ZISL vs ZSLE) was performed in terms of limb graft occlusion.Results: The 30 day technical and clinical success rates were 97.5% and 99.5%, respectively. Median follow-up period was 25.5 months (interquartile range [IQR]: 12–43.25). The 5 year survival rate was 73.6%. The estimated 5 year outcomes in terms of freedom from type I/III endoleak, freedom from surgical conversion, freedom from limb graft occlusion, freedom from any device-related reintervention, and freedom from graft infection were 88.6% (95% CI [confidence interval]: 83.4%–93.1%), 95.8% (95% CI: 92.7%–97.1%), 93.6% (95% CI: 90.2%–96.8%), 87% (95% CI: 83.3%–91.6%), and 97.7% (95% CI: 95.1%–98.9%), respectively. About limb configuration, no differences were found in terms of 5 year freedom from limb graft occlusion (ZSLE 93.4% [95% CI: 89.8%–95.5%] vs ZISL 94.3% [95% CI: 90.1%–95.9%], p=0.342; log-rank 0.903).Conclusion: Zenith Alpha Abdominal in elective EVAR offered satisfactory early and 5 year outcomes with low complication rates. Limb graft occlusion continued to be an issue. Limb configuration did not affect outcomes.Clinical Impact The authors describe satisfactory early and 5 year outcomes of Zenith Alpha Abdominal in elective endovascular aortic repair in the framework of a multicenter regional retrospective registry. At 5 years freedom from type I endoleak was 88.6%, and rate of endograft infections and conversions to open repair were very low. in the present study. Hot topic about about Zenith stent-graft still remains the limb graft occlusion with a 30-day overall rate of 2%, and estimated 5-year freedom from limb graft occlusion of 93.6%. Limb graft configuration did not affect limb graft occlusion rate. A standardized protocol including iliac stenting should be adopted to reduce kimb graft occlusion.

Published
2024
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28. Physician-modified funnel-shaped covered stent for selective false lumen exclusion in chronic type B aortic dissection.

Author

Torri L, Nana P, Panuccio G, Torrealba JI, Yousef El Sarhan D, and Kölbel T

Abstract

Purpose: To describe the technique of off-centering a balloon-expandable covered stent for selective occlusion of a distal entry tear (ET) in a patient, conservatively treated for chronic type B aortic dissection (cTBAD), presenting FL expansion., Technique: A 63-year-old male, with conservatively managed cTBAD, presented at follow-up with FL partial thrombosis and expansion (thoracic aorta FL from 21 mm to 27 mm and abdominal aorta FL from 11 mm to 15 mm in 6 months). No proximal ET was identifiable. Distal FL perfusion was caused by an ET in the abdominal aorta feeding a 2 mm accessory renal artery (ARA). As the aortic diameter was below the threshold for endovascular repair, a selective occlusion of the distal ET and ARA was planned. A balloon-expandable covered stent was modified by off-centering the covered stent proximally and resulting in a funnel-shape occluder after deployment across the ET into the ARA. To prevent type Ic endoleak due to possible FL expansion caused by an intra-operatively detected phrenic artery (PA), coils were deployed into the lumen of the modified stent and the ARA. The pre-discharge computed tomography angiography showed exclusion of both the ARA and ET and a type 2 endoleak from the PA., Conclusion: A balloon-expandable covered stent can be modified by off-centering the covered stent resulting in a funnel shape to adapt to different diameter requirements., Competing Interests: Declaration of conflicting interestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Published
2024
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29. Injuries in non-professional padel tennis players. Results of a survey of the Italian Federation of Tennis in Liguria, Italy.

Author

Tagliafico AS, Torri L, and Righetto R

Subjects
Humans, Adult, Middle Aged, Aged, SARS-CoV-2, Surveys and Questionnaires, Tennis injuries, COVID-19, Sports
Abstract

Background: To understand padel tennis injuries occurrence in Liguria, Italy. Paddle is a well know racquet sport, similar to tennis. padel tennis has been widely adopted in Liguria only in the last 4 years, however sport practice was largely reduced by the worldwide spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)., Methods: A questionnaire (N.=19 questions) was sent to all members of the Italian Federation of Tennis involved in official tournaments of padel tennis. We collected data on the number of injuries, the most frequent injuries, their distribution, type, location, the moment at which these occurred, and the diagnostic modality used to make the diagnosis., Results: A total of 800 Italian padel tennis players took part in the survey (mean age: 49±22 years). In total, 85 injuries were registered in 2020/2021 up to 1/6/2021. The majority of lesion was located on the lower limb N.=49/85 with the knee N.=16/49 highly affected. Then, the majority of lesion of the upper limb were localized al the elbow N.=22/36, the majority epicondylitis., Conclusions: Padel tennis injuries resulted more common in the lower limb and the elbow was the most affected area at the upper limb.

Published
2023
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30. [ 18 F]-Fludeoxyglucose Positron Emission Tomography/Computed Tomography with Radiomics Analysis in Patients Undergoing Aortic In-Situ Reconstruction with Cryopreserved Allografts.

Author

Berchiolli R, Torri L, Bertagna G, Canovaro F, Zanca R, Bartoli F, Mocellin DM, Ferrari M, Erba PA, and Troisi N

Abstract

Background: The aim of this study was to evaluate the effectiveness of positron emission tomography/computed tomography with [ 18 F]-fludeoxyglucose (FDG-PET/CT) and radiomics analysis in detecting differences between the native aorta and the abdominal aortic allograft after the total eradication of infection in patients undergoing infected graft removal and in situ reconstruction with cryopreserved allografts., Methods: Between January 2008 and December 2018, 56 vascular reconstructions with allografts have been performed at our department. The present series included 12 patients undergoing abdominal aortic in situ reconstruction with cryopreserved allografts. During the follow-up, all patients underwent a total-body [ 18 F]FDG PET/CT with subsequent radiomics analysis. In all patients, a comparative analysis between the data extracted from native aorta and cryopreserved graft for each patient was performed., Results: All patients were male with a mean age of 72.8 years (range 63-84). Mean duration of follow-up was 51.3 months (range 3-120). During the follow-up, 2 patients (16.7%) needed a redo allograft-related surgical intervention. Overall, the rate of allograft dilatation was 33.3%. No patient had a redo infection during the follow-up. Radiomics analysis showed a different signature of implanted allograft and native aorta. Comparative analysis between the native aortas and cryopreserved allografts (dilated or not) showed several statistical differences for many texture features., Conclusions: The higher metabolic activity of allografts could indicate a state of immune-mediated degeneration. This theory should be proven with prospective, multicentric studies with larger sample sizes.

Published
2022
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