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The purpose of the study was to evaluate the impact of the financial aid programme aimed at discounting tuition fees at one of Venezuela's first private universities on early and late student departure, both from the degree programme and the institution, as well as on graduation. The propensity score matching was used by calculating the average treatment effect estimator under parametric and non-parametric methodologies such as nearest neighbours, Kernel, or local linear regression. The results indicate that although there is evidence of the programme exerting a positive impact on early student departure to a greater extent (reductions between 8% and 15%), the impact tends to be considerably less when it comes to reducing late student departure (between 1% and 5%), and it had no impact on graduation.

A adolescência é marcada por um complexo processo de crescimento e desenvolvimento em que se destacam diversas mudanças biopsicossociais. Frente a estas transformações, o desenvolvimento da sexualidade está intimamente ligado ao desenvolvimento integral do indivíduo. Nesse contexto, através de um diagnóstico situacional realizado por discentes de Medicina da Universidade, notou-se a defasagem no conhecimento em sexualidade dos adolescentes de uma escola estadual. O presente estudo objetiva comprovar essa deficiência educacional. Para tal, os discentes realizaram atividades educativas e interativas para avaliação. Os resultados comprovam que, apesar de certos conhecimentos corretos, há muitos mitos e inverdades que precisam ser desfeitos entre os adolescentes, a fim de trazer maior consciência corporal e sexual. Conclui-se, então, a necessidade de intervenções eficazes e educativas para adolescentes.

The aim of this research was to evaluate the impact of the financial aid programme at a private university in Venezuela on the outcome variables of post-graduation or social mobility, such as remuneration at the time of graduation and at present, and the probability of entering the labour market. We used the fuzzy regression design for multiple treatments, given that the programme consists of the application of percentage discounts on tuition, where the allocation index only shows the probability of being treated, thus finding beneficiary individuals to the right and to the left of the threshold at each of the cut-off points. The results show that there are differences in labour market insertion between treated and untreated individuals, in favour of the former, but higher wages for non-beneficiaries. As for the estimates of the fuzzy regression regressions for both remuneration at the different points in time and labour market insertion, it is not possible to identify a positive impact of the treatment. [ABSTRACT FROM AUTHOR]

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Background: Hematopoietic stem cell transplant (HSCT) is currently the only widely available curative option for patients with sickle cell disease (SCD). Alloimmunization in this population is frequent and can complicate transfusion management during the HSCT period. The case of a pediatric patient with severe SCD clinical phenotype, multiple alloantibodies (9), and hyperhemolysis syndrome who underwent haploidentical HSCT is described. Study Design and Methods: The patient was known for an anti‐e, despite RHCE*01.01 allele, which predicts a C‐ c+ E‐ weak e+ phenotype. Donors matching the patient's extended phenotype were targeted for RHCE genotyping. Results: Donors homozygotes or heterozygotes for RHCE*01.01 were selected for compatibility analyses and ranked based on strength of reactions. Discordance between zygosity and strength of reactions was observed, as the most compatible donors were heterozygotes for RHCE*01.01. In total, the patient received seven RBC units from two different donors during HSCT process without transfusion reaction or development of new alloantibodies. Six months post‐HSCT, his hemoglobin level is stable at around 120 g/L and his chimerism is 100%. Discussion: This case highlights the complexity of transfusion management during HSCT of alloimmunized patients with SCD. Collecting sufficient compatible units requires early involvement of transfusion medicine teams and close communication with the local blood provider. Genotyping of donors self‐identifying as Black is useful for identifying compatible blood for those patients but has some limitations. HSCT for heavily alloimmunized patients is feasible and safe with early involvement of transfusion medicine specialists. Further research on the clinical impact of genotypic matching is needed. [ABSTRACT FROM AUTHOR]