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2. Clinical relevance of circulating angiogenic cells in patients with ischemic stroke

Author

Francisco Rodríguez-Esparragón, Laura B. Torres-Mata, Juan Carlos López-Fernández, Laura Cappiello, Jesús M. González-Martín, Bernardino Clavo, Jaime A. Serna-Gómez, Lidia Estupiñán-Quintana, Cristina Torres-Ascensión, and Jesús Villar

Subjects
Ischemic stroke, Endothelial progenitor cells, Circulating angiogenic cells, Colony forming cells, Late outgrowth endothelial cells, Biomarkers, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Abstract Background Endothelial progenitor cells (EPCs) are circulating angiogenic cells with endothelial features associated with risk for stroke. We aimed to delve into their functional characteristics. EPCs were isolated and cultured from Ischemic Stroke (IS) patients and predictors of their variance evaluated. Methods This is a single-center observational study evaluating 187 consecutively hospitalized patients with IS. EPCs were isolated from blood samples. The number of circulating angiogenic cells (CACs), colony-forming units (CFU-ECs) and the emergence of late outgrowths endothelial cells (LOECs) were counted. We collected clinical variables and measured the stromal cell-derived factor 1 alpha (SDF1α) serum levels. We also examined the relative telomere length and the expression of osteogenic gene markers in CACs. Results CACs counts and CFU-ECs colony numbers were positively correlated (rho = 0.41, p

Published
2022
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5. Effects of Ozone Treatment on Personal Protective Equipment Contaminated with SARS-CoV-2

Author

Bernardino Clavo, Elizabeth Córdoba-Lanús, Francisco Rodríguez-Esparragón, Sara E. Cazorla-Rivero, Omar García-Pérez, José E. Piñero, Jesús Villar, Angeles Blanco, Cristina Torres-Ascensión, José L. Martín-Barrasa, Jesús M. González-Martin, Pedro Serrano-Aguilar, and Jacob Lorenzo-Morales

Subjects
COVID-19, decontamination, personal protective equipment, oxidative stress, ozone treatment, reactive oxygen species, Therapeutics. Pharmacology, RM1-950
Abstract

Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is causing profound health, economic, and social problems worldwide. Management of personal protective equipment (PPE) and its potential limited availability have created concerns about the increased risks for healthcare professionals at hospitals and nursing homes. Ozone is a powerful oxidant agent. The objectives of this study were to examine the effects of ozone treatment on PPE contaminated with SARS-CoV-2, and to explore whether relative humidity could modify those effects. Methods: PPE contaminated by heat-inactivated SARS-CoV-2 were treated with different ozone concentrations, exposure times, and relative humidity conditions. SARS-CoV-2 gene amplification was assessed by real-time polymerase chain reaction. Results: There was no amplification of SARS-CoV-2 in PPE after the following ozone exposures: 30 s at 10,000 ppm (20 g/m3), 5 min at 4000 ppm, and 10 min at 2000 ppm. At lower ozone concentrations, 4–12 ppm (0.008–0.024 g/m3), the effects were highly dependent on the relative humidity conditions. Conclusions: Oxidative stress induced by ozone exposure eliminated heat-inactivated SARS-CoV-2 in different PPE components under appropriate exposure times, ozone concentrations, and relative humidity conditions. These findings could have implications in decreasing the risk of contamination associated with personal protective equipment management and in increasing its availability. Further research in the original SARS-CoV-2 strain is guaranteed.

Published
2020
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12. Effects of Ozone Treatment on Personal Protective Equipment Contaminated with SARS-CoV-2

Author

Jacob Lorenzo-Morales, Elizabeth Córdoba-Lanús, Omar García-Pérez, Cristina Torres-Ascensión, Francisco Rodríguez-Esparragón, Bernardino Clavo, Jesús Villar, José L Martín-Barrasa, Sara Cazorla-Rivero, Jesús M González-Martín, Angeles Blanco, José E. Piñero, and Pedro Serrano-Aguilar

Subjects
0301 basic medicine, Ozone, Physiology, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), 030106 microbiology, Clinical Biochemistry, ozone treatment, 010501 environmental sciences, 01 natural sciences, Biochemistry, Article, Toxicology, 03 medical and health sciences, chemistry.chemical_compound, Medicine, oxidative stress, Relative humidity, Ozone exposure, Molecular Biology, Personal protective equipment, 0105 earth and related environmental sciences, reactive oxygen species, Health professionals, business.industry, SARS-CoV-2, lcsh:RM1-950, COVID-19, Cell Biology, Contamination, decontamination, lcsh:Therapeutics. Pharmacology, chemistry, personal protective equipment, Nursing homes, business
Abstract

Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is causing profound health, economic, and social problems worldwide. Management of personal protective equipment (PPE) and its potential limited availability have created concerns about the increased risks for healthcare professionals at hospitals and nursing homes. Ozone is a powerful oxidant agent. The objectives of this study were to examine the effects of ozone treatment on PPE contaminated with SARS-CoV-2, and to explore whether relative humidity could modify those effects. Methods: PPE contaminated by heat-inactivated SARS-CoV-2 were treated with different ozone concentrations, exposure times, and relative humidity conditions. SARS-CoV-2 gene amplification was assessed by real-time polymerase chain reaction. Results: There was no amplification of SARS-CoV-2 in PPE after the following ozone exposures: 30 s at 10,000 ppm (20 g/m3), 5 min at 4000 ppm, and 10 min at 2000 ppm. At lower ozone concentrations, 4&ndash, 12 ppm (0.008&ndash, 0.024 g/m3), the effects were highly dependent on the relative humidity conditions. Conclusions: Oxidative stress induced by ozone exposure eliminated heat-inactivated SARS-CoV-2 in different PPE components under appropriate exposure times, ozone concentrations, and relative humidity conditions. These findings could have implications in decreasing the risk of contamination associated with personal protective equipment management and in increasing its availability. Further research in the original SARS-CoV-2 strain is guaranteed.

Published
2020
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14. Prevalencia de la enfermedad renal crónica y factores asociados en la población asistida en atención primaria de España: resultados del estudio IBERICAN

Author

Llisterri, José Luis, primary, Micó-Pérez, Rafael Manuel, additional, Velilla-Zancada, Sonsoles, additional, Rodríguez-Roca, Gustavo Cristóbal, additional, Prieto-Díaz, Miguel Ángel, additional, Martín-Sánchez, Vicente, additional, Barquilla, Alfonso, additional, Polo-García, José, additional, Segura-Fragoso, Antonio, additional, Cinza-Sanjurjo, Sergio, additional, García, Alfonso Barquilla, additional, Rodríguez, Ángel Díaz, additional, Cervantes, Carlos Escobar, additional, Moreno, Francisco Javier Alonso, additional, Roca, Gustavo Cristóbal Rodríguez, additional, Martín, Jesús Vergara, additional, Caro, José Luis Llisterri, additional, Badimón, Juan José, additional, García, José Polo, additional, Padial, Luis Rodríguez, additional, Prieto, Miguel Ángel, additional, Pérez, Rafael Vidal, additional, Sanjurjo, Sergio Cinza, additional, Jiménez, Sonia Miravet, additional, Zancada, Sonsoles Velilla, additional, Téllez, Antonio López, additional, de Los Ángeles Ortega Osuna, Maria, additional, Cid, Cristóbal Prieto, additional, Fajardo, María José Hidalgo, additional, Serna, José Lorente, additional, Requena, Ángel Domínguez, additional, Cañizares, Ricardo Alberola, additional, Peña, Manuel Ruiz, additional, Collado, Filomena Herrero, additional, Vázquez, Marcela Montes, additional, Garrido, Rafael Ángel Carrascal, additional, Lozano, María Reyes Herrera, additional, Oliva, Beatriz Ortiz, additional, Anguita, Francisco José, additional, Ibáñez, Carmen Pérez, additional, Rodríguez, Carlos Alberto Cabrera, additional, Rodríguez, María José Cruz, additional, Ruiz, Sandra Bonilla, additional, González, Rocío Reina, additional, Sánchez, Salomé Abad, additional, Martínez, Inmaculada Santana, additional, Jordán, Rafael Sánchez, additional, Navas-Parejo, Juan María Ramos, additional, Torres, José Manuel Ramírez, additional, Poveda, José María Beltrán, additional, Benayas, María Adoración de Cruz, additional, Gil, Carmen Fernandez, additional, Alcaine, Jon Iñaki Esturo, additional, Quintero, Antonio Mora, additional, Cepas, Fernando Leiva, additional, Martín, José Luis Carrasco, additional, Criado, Emilio García, additional, Blanco, Mercedes Vázquez, additional, Ortiz, Isabel Mora, additional, Mendoza, Leovigildo Ginel, additional, Rodríguez, Juan Carlos Aguirre, additional, Rodríguez, Esperanza María Romero, additional, Vázquez, José Acevedo, additional, Ballesteros, Juan Gabriel García, additional, Lara, María de La Paz Fernández, additional, Moreno, Patricia Agüera, additional, Maturana, Eduardo Paños, additional, Expósito, Juan Manuel Ignacio, additional, Peñas, Noelia Carrillo, additional, Faya, Carmen María Abad, additional, Duque, Ana Marina Almagro, additional, Camisón, Rubén Torrescusa, additional, Polo, Paloma Menéndez, additional, García, Marina Peña, additional, Fernández, Cristina López, additional, Torres, Ascensión Estepa, additional, Jansen, Miguel Gutiérrez, additional, González, Esperanza Loizaga, additional, Matarin, Lisardo García, additional, Luna, Enrique José Gamero de, additional, Rivero, Javier Benítez, additional, Gómez González, María José, additional, Montes, Carmen Gómez, additional, Calvo, Eva Trillo, additional, Calvo, Concepción Bayod, additional, Natividad, Susana Larripa de La, additional, Lambea, Germán Grasa, additional, Marín, Emilio Jiménez, additional, Gonzalvo, Ana Cristina Navarro, additional, Martínez Barseló, Antonio Pablo, additional, León, Irene Peña, additional, Fernández, E. Lidia Gutiérrez, additional, Mantecón, Fernando Andrés, additional, Garrido, Ana Belén García, additional, Escalante, Asunción Velez, additional, Rentería, Luisa Alonso, additional, Jiménez, Jesús Sainz, additional, Alles, Guillermo Pombo, additional, Garrote, Juan Antonio Divison, additional, Sotodosos, Pedro Martínez, additional, Fuster, Juan Antonio Vivancos, additional, Palencia, María García, additional, Moraleda, José Ambrosio Torres, additional, Ballesteros, Sara González, additional, Adrados, Ana Carmen Gil, additional, Cabrera, Antonio González, additional, Fernández, Miguel Ángel Babiano, additional, García, Guillermo Rico, additional, Criado-Álvarez, Juan José, additional, Moreno, Pilar Torres, additional, Aguirregaviria, Francisco Javier Arribas, additional, Martínez, Alicia Sahuquillo, additional, Béjar, Lourdes María Santos, additional, Peralta, Miguel Laborda, additional, Castro, Raúl Piedra, additional, Altozano, Carlos Santos, additional, Polo, Lucía González-Tarrio, additional, Maresca, Pedro Valiente, additional, Santana, Reinilda Mota, additional, Ledesma, Noemi Elizabeth Terrero, additional, Espada, Noelia Garrido, additional, Calvi, Gabriela Delia Rosa Zambrana, additional, Montero, Juan Lorenzo Gutiérrez, additional, Gil, Juan Ignacio López, additional, Ortega, María Dolores Fernández, additional, Roncal, Miren Elizari, additional, Serrano, María Ascensión López, additional, Fuente, Nuria Esther Adrián de La, additional, Larrea, Belén Angulo Fdez. de, additional, Fernández, Naiara Cubelos, additional, Gómez, Guiomar Luz Ferreiro, additional, Rodríguez, Diana Gómez, additional, Tuñón, Sonia María Andrés, additional, González, María Ajenjo, additional, Olea, Serafín de Abajo, additional, Regueras, Juan José León, additional, Nieto, César Manuel Gallego, additional, Mallada, Delio Vázquez, additional, García, Maria de La O Gutiérrez, additional, Rodríguez, Pablo Baz, additional, García, José Ignacio Ferradal, additional, Martínez, Blanca Delia de Román, additional, Pérez, Ana Arconada, additional, Atoui, Omar Mahmoud, additional, Bayón, Álvaro Morán, additional, Olmo, María Teresa Armenteros del, additional, Herreros, Fco. Javier García-Norro, additional, Rodríguez, Enrique Méndez, additional, Pineda, Diana María Narganes, additional, Ainaga, Verónica Ortiz, additional, Guevara, Milagros Sonlei Sánchez, additional, Ferreiro, Laura Villota, additional, Grande, M. Teresa Grande, additional, Gracía, Francisco Vicente Martínez, additional, García, María Dolores Moriano, additional, Muñoz, Beatriz Jiménez, additional, Marcelino, Gemma Rovira, additional, Valverde, Diana Elizabeth Fernández, additional, Bernadó, Roser Rodó, additional, Lupiáñez, María Teresa Ortiz, additional, Najih, Najlaa, additional, Parra, José María Diéguez, additional, Acebo, María Rosa Benedicto, additional, Vicien, Mari Luz Bravo, additional, Estella, Alberto Ramón León, additional, Gómez, Juan Antonio Muñoz, additional, Muntané, Alicia Mostazo, additional, Abarca, Isabel Ortega, additional, Fargas, Anna Gasol, additional, Escudero, Brenda Elizabeth Riesgo, additional, Riesgo, Susana Elizabeth, additional, Castellvi, Edgar Zaballos, additional, Sagarra, Celia Cols, additional, Fernández, Marta Herranz, additional, Presas, Josep Alins, additional, Pérez, Idaira Damas, additional, García, Rosa M. Alcolea, additional, Collado, Inés Monte, additional, Martínez, Roberto Genique, additional, Villanueva, María José Guasch, additional, Martínez, Teresa Rama, additional, Pena, Lucio Pinto, additional, Royo, Josefa María Panisello, additional, Gil, Inés Gil, additional, Montero, Alberto Calderón, additional, Gómez, María del Mar Zamora, additional, Cebrián, Elena Alarcón, additional, Acin, María José Piñero, additional, Sacristán, Celia Pecharromán, additional, Vicente, M. Soledad Mayayo, additional, Unanua, María Paz Pérez, additional, Henrich, Nuria Marañón, additional, Monreal, Saray Gómez, additional, Pedro, Sonia Redondo de, additional, Pozo, Blanca Sanz, additional, Martínez, Irene Moreno, additional, Uriarte, Beatriz López, additional, Velasco, Carmelina Sanz, additional, Aguirre, Amaya Gárriz, additional, Teijido, Montserrat Rivera, additional, Jaén, Germán Reviriego, additional, Pascual-Salcedo, José Ignacio Aza, additional, Gallego, Josefa Vázquez, additional, Rodilla, Julia Caballer, additional, Herrera, Aida, additional, Martínez, Ezequiel Arranz, additional, Calvo, Ana María Gómez, additional, Oliva, Paula Morán, additional, Béjar, María Milagros González, additional, Hitos, Julio Antonio Heras, additional, Vallejo, Olga García, additional, Vargas, Manuel de Jesús Frías, additional, Boguerin, María Jesús Castillejo, additional, Lerin, Aurora García, additional, Tablado, Miguel Ángel María, additional, García, Elena Concepción García, additional, Acero, Leticia de Miguel, additional, Oñate, Carmen Zárate, additional, Apoita, Aránzazu Barranco, additional, Belloso, María Ester Montes, additional, Velasco, Ana María Huertas, additional, Jiménez, Rafael Sáez, additional, Pascual, Julia Natividad García, additional, Zuluaga, María Clemencia Zuluaga, additional, Perez, María Cruz Díez, additional, García, Antonio Ruiz, additional, Jelsbak, Cristina Murillo, additional, Oria, Virginia Lasso, additional, Gamarra, Amelia González, additional, Fuster, Vicente Pascual, additional, Bort, María Dolores Aicart, additional, Gómez, Natividad Vázquez, additional, Gasco, Carlos Lluna, additional, Barber, Teresa Amoros, additional, Cano, Pedro Antonio Medina, additional, Moncho, Miguel Monteagudo, additional, Muñoz, María Jesús Larré, additional, Hernández, Raquel Navarro, additional, Egea, Francisco José Martínez, additional, Tramontano, Antonio, additional, Royo, Marta Ferrer, additional, Saura, Belén Persiva, additional, Torres, Juan A. Contreras, additional, Moliner, José María Tirado, additional, Penalba, Alejandro Salanova, additional, Alberola, Ariadna Cucó, additional, Ros, Fernando María Navarro I., additional, Llicer, Enrique Beltrán, additional, Novás, Ana Seoane, additional, Valls, Inmaculada Martín, additional, Mahiques, Gracia Verdú, additional, Forcada, Enrique Peña, additional, Gómez, Nieves Aguilar, additional, García, Francisco Javier Sanz, additional, Bueso, M. Dolores Paradís, additional, Romero, María Eugenia Alegre, additional, Camus, Antonio Francés, additional, Peinado, María Amparo Antón, additional, Santos, Rosa Latorre, additional, Marín, María Asunción Palomar, additional, García, María Carmen Botella, additional, Fresquet, Eva Sánchez, additional, Paños, Pedro Sala, additional, Ruiz, Tomás Sánchez, additional, Valero, Rosa Ana Valero, additional, Vicente, María Seoane, additional, Llinares, Magdalena Martín, additional, Alegre, Antonio Masiá, additional, Verdú, Irene Lluch, additional, Carratala, Vicente Pallares, additional, Roca, Francisco Valls, additional, Pérez, Rafael Manuel Micó, additional, García, Jacinto Espinosa, additional, Romo, José Ignacio Prieto, additional, Fernández, Leandro Fernández, additional, Sierratapia, Javier, additional, Regidor, Nieves Moreno, additional, Sánchez, Francisco Javier Zaballos, additional, Moreno, Ana Moreno, additional, Barrera, Francisco Carramiñana, additional, Vázquez, Juan José Torres, additional, Samino, María José Gamero, additional, Rodríguez, Miguel Ángel de Santiago, additional, Martínez, Pablo Rafael Gómez, additional, Becerra, Antonio Carlos Elías, additional, Olivera, Javier Soto, additional, Cambero, Víctor, additional, Ávila, Julián Domínguez, additional, Fuentes, Andrés Simón, additional, Jiménez, Jorge Manuel de Nicolás, additional, Fraile, Dimas Igual, additional, Barco, Guadalupe Nieto, additional, Ramos, Ignacio Araujo, additional, Berrocal, María Luz Serrano, additional, Ramírez, Francisco Buitrago, additional, Marcos, Minerva Gallego, additional, González, Félix Suárez, additional, Carrasco, Victoriano Chavero, additional, Peguero, Francisco Guerra, additional, Vega, Francisco Javier Sánchez, additional, Mas, Manuel Tejero, additional, Donoso, Alba Palmerín, additional, Yedro, Miguel Turégano, additional, Rojas, María Beatriz Esteban, additional, Moreno, Fátima Cabezudo, additional, Saldaña, Nawson Elver Quevedo, additional, Fenés, María del Mar García, additional, Florencio, Timotea Garrote, additional, Toro, José María Fernández, additional, Rañal, Alejandra Rey, additional, Río, Elena García del, additional, Pol, Enrique Nieto, additional, Fernández, Julio Álvarez, additional, Álvarez, Pilar Alonso, additional, Gómez, María Luisa Jorge, additional, Guerrero, Antonio Calvo, additional, Colomina, Isabel Celemín, additional, Casal, Lucía Barreiro, additional, Moreno, Juana Fernández, additional, Martínez, María Angelines Carballal, additional, Rodríguez, Nabor Díaz, additional, Paredes, Carlos Moral, additional, García, Dolores Recarey, additional, Mato, Fco. Javier Iglesias, additional, Ulloa, Antonio Fouz, additional, González, Amparo Fidalgo, additional, Parada, Noelia Dios, additional, Sabarís, Patricia Conde, additional, Pérez, Ana Isabel Rodríguez, additional, Palacio, Ana Inés García, additional, Varela, Víctor Julio Quesada, additional, Iglesias, Lidia Romero, additional, Llerena, Ángel Lado, additional, Rodríguez, Carmen Lires, additional, Diaz, María Luisa Carretero, additional, Arias, José Carreira, additional, Camino, Jose Luis Vázquez, additional, Penas, María del Carmen Torreiro, additional, Freire, Sandra Yáñez, additional, Aldana, Daniel Rey, additional, Díaz, Carlos Piñeiro, additional, Romanos, Fernando García, additional, González, Antonia Moreno, additional, Sastre, María Lara Amengual, additional, Palli, Susana Martínez, additional, Bauza, José Alfonso Ramón, additional, Bolinches, José Ortiz, additional, Fernández, Carmen Fernández, additional, Vázquez, María Isabel Orlandis, additional, Mezquita, Ana Sanchís, additional, Aramburu, Fernando Unceta, additional, Morant, Juan Fernando Peiró, additional, Amengual, Ana Moyá, additional, García, Isidro Godoy, additional, Sevillano, Fernando Rubio, additional, González, María Isabel González, additional, Souto, Marta Pérez, additional, Contreras, Raquel de León, additional, González, Sara Isabel Almeida, additional, Diez, Irene Almería, additional, Sánchez, Virginia María Mirabal, additional, Lavado, Francisco José Escobar, additional, Pérez, Yoel Anta, additional, Hernández, Nayra Sánchez, additional, Jerez, Juan Luis Alonso, additional, Koch, Ricardo, additional, Mendoza, Nayra Ramírez, additional, Hernández, Héctor Suárez, additional, Escobar, Francisco Jesús Morales, additional, Zancada, Sonsoles María Velilla, additional, Sabarís, Rafael Crespo, additional, Jiménez, Óscar Fernando Isaula, additional, Puga, Jesús Manuel González, additional, Ávila, Jorge Antonio Benaín, additional, González, Óscar del Toro, additional, Íñigo, Laura Sánchez, additional, Pérez, Inés Sanz, additional, Nubla, José Félix Zuazagoitia, additional, Ituiño, Ana Echebarría, additional, Tris, Gregorio Mediavilla, additional, Bosch, María Carmen Noriega, additional, González, Esther, additional, Macho, María Luisa Ruiz, additional, Olmo, Ruth Sendino del, additional, Prado, Asunción Olagorta de, additional, Muguerza, Ana López de Viñaspre, additional, Iriso, Jesús Iturralde, additional, Martínez, María José Pérez, additional, Carbonell, Ana Piera, additional, Fernández, Margarita Alonso, additional, Cuadrado, María Montserrat Rueda, additional, Rodríguez, Rodrigo Abad, additional, Cabo, José Miguel Álvarez, additional, Rodríguez, Rubén Sánchez, additional, Cabo, Eva María Cano, additional, Secin, Anny Romero, additional, Díaz, Miguel Ángel Prieto, additional, Fernández, Juan Jesús García, additional, Bueno, Vicente Llorca, additional, Pérez, Ana María Ballesteros, additional, López, Domingo J. Rubira, additional, Franco, María Dolores Esteve, additional, Pablo, Elena Sánchez, additional, López, María Teresa Palacios, additional, Meroño, Juan Castillo, additional, Martínez, José María Lobo, additional, Martínez, Isabel María Peral, additional, Carrasco, J. Eduardo Carrasco, additional, and González, Armando Santo, additional

Published
2021
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15. Effects of Ozone Treatment on Personal Protective Equipment Contaminated with SARS-CoV-2

Author

Clavo, Bernardino, primary, Córdoba-Lanús, Elizabeth, additional, Rodríguez-Esparragón, Francisco, additional, Cazorla-Rivero, Sara E., additional, García-Pérez, Omar, additional, Piñero, José E., additional, Villar, Jesús, additional, Blanco, Angeles, additional, Torres-Ascensión, Cristina, additional, Martín-Barrasa, José L., additional, González-Martin, Jesús M., additional, Serrano-Aguilar, Pedro, additional, and Lorenzo-Morales, Jacob, additional

Published
2020
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20. Propagación clonal y saneamiento del cultivar de uva de mesa Napoleón mediante la aplicación de tecnicas de cultivo 'in vitro' de tejidos y termoterapia / Ascensión Ibáñez Torres ; directores Ventura Padilla Villalba, Manuel Valero Roche

Author

Ibañez Torres, Ascensión

Subjects
581.1(043), Fisiología vegetal
Abstract

Tesis-Universidad de Murcia., Consulte la tesis en: BCA. GENERAL. ARCHIVO UNIVERSITARIO. D 574., Consulte la tesis en: BCA. GENERAL. DEPOSITO. T.M-1949.

Published
2018

21. Effect of flavonoids isolated from Tridax procumbens on the growth and toxin production of Microcystis aeruginos

Author

Mecina, Gustavo Franciscatti, primary, Chia, Mathias Ahii, additional, Cordeiro-Araújo, Micheline Kézia, additional, Bittencourt-Oliveira, Maria do Carmo, additional, Varela, Rosa Maria, additional, Torres, Ascensión, additional, González Molinillo, José María, additional, Macías, Francisco Antonio, additional, and da Silva, Regildo Márcio Gonçalves, additional

Published
2019
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22. SAR studies of epoxycurcuphenol derivatives on leukemia CT-CD4 cells

Author

Química Orgánica, G. Galindo, José L., Macías, Mariola, González Molinillo, José María, Muñoz-Suano, Alba, Torres, Ascensión, Varela Montoya, Rosa, García-Cozar, Francisco, Macías Domínguez, Francisco Antonio, Química Orgánica, G. Galindo, José L., Macías, Mariola, González Molinillo, José María, Muñoz-Suano, Alba, Torres, Ascensión, Varela Montoya, Rosa, García-Cozar, Francisco, and Macías Domínguez, Francisco Antonio

Abstract

Bioactive natural products are a potential source of new pharmaceuticals since they offer new modes of action and more specific activities. The use of derivatization also enables the optimal structure for their biological activity to be determined. In this study several epoxycurcuphenol derivatives were synthesized. The substitution pattern on the aromatic and oxirane rings was varied along with that at the benzylic position and the length of the side chain was altered. These changes were made in order to gain a deeper understanding of the structural requirements for activity. The biological activities of these compounds were evaluated on the human leukemia cell line Jurkat using an antiproliferative assay. The activity results and structural requirements are discussed.

Published
2018

25. Evaluation of the Phytotoxicity of Urochloa humidicolaRoots by Bioassays and Microscopic Analysis. Characterization of New Compounds

Author

Feitoza, Rodrigo B. B., Varela, Rosa M., Torres, Ascensión, Molinillo, José M. G., Lima, Helena R. P., Moraes, Luiz F. D., Da Cunha, Maura, and Macías, Francisco A.

Abstract

Herbicides are a key element in agriculture but they do cause environmental problems and natural alternatives are being sought. In this context, invasive plants could provide an as yet unexplored source for the development of future herbicides. Urochloa humidicolahas great invasive potential in Brazilian environments as it hampers the establishment of other plants. The phytotoxicity of U. humidicolaroot extracts has been evaluated, and the major components have been identified. The phytotoxicity of the extract was assessed in the wheat coleoptile assay on seeds of troublesome weeds and on Anadenanthera colubrina, a tree species used in ecological restoration programs. The ethyl acetate extract showed the highest activity, and the most affected weeds were E. crus-galli, M. maximus, and A. viridiswith the latter weed more affected by the extract than by the herbicide Logran. Microscopic ultrastructural analysis of A. colubrinaroots indicated possible signals of cell death. Seven compounds were identified in the ethyl acetate extract of which one diterpene and four saponins are new. Six of these compounds were tested in the wheat coleoptile bioassay. The most active were diterpene 1and saponins 2, 3, and 6. The phytotoxic activity of U. humidicolaexplains the issues observed in ecological restoration with A. colubrinain the presence of Urochloaspecies, and its effect on weeds reinforces its potential use in agriculture.

Published
2020
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34. Aloe barbadensis: how a miraculous plant becomes reality

Author

Química Orgánica, Chinchilla, Nuria, Carrera Fernández, Ceferino, G. Durán, Alexandra, Macías, Mariola, Torres, Ascensión, Macías Domínguez, Francisco Antonio, Química Orgánica, Chinchilla, Nuria, Carrera Fernández, Ceferino, G. Durán, Alexandra, Macías, Mariola, Torres, Ascensión, and Macías Domínguez, Francisco Antonio

Abstract

Aloe barbadensis Miller is a plant that is native to North and East Africa and has accompanied man for over 5,000 years. The aloe vera plant has been endowed with digestive, dermatological, culinary and cosmetic virtues. On this basis, aloe provides a range of possibilities for fascinating studies from several points of view, including the analysis of chemical composition, the biochemistry involved in various activities and its application in pharmacology, as well as from horticultural and economic standpoints. The use of aloe vera as a medicinal plant is mentioned in numerous ancient texts such as the Bible. This multitude of medicinal uses has been described and discussed for centuries, thus transforming this miracle plant into reality. A summary of the historical uses, chemical composition and biological activities of this species is presented in this review. The latest clinical studies involved in vivo and in vitro assays conducted with aloe vera gel or its metabolites and the results of these studies are reviewed.

Published
2013

35. SAR studies of epoxycurcuphenol derivatives on leukemia CT-CD4 cells

Author

Química Orgánica, G. Galindo, José L., Macías, Mariola, González Molinillo, José María, Muñoz-Suano, Alba, Torres, Ascensión, Varela Montoya, Rosa, García-Cozar, Francisco, Macías Domínguez, Francisco Antonio, Química Orgánica, G. Galindo, José L., Macías, Mariola, González Molinillo, José María, Muñoz-Suano, Alba, Torres, Ascensión, Varela Montoya, Rosa, García-Cozar, Francisco, and Macías Domínguez, Francisco Antonio

Abstract

Bioactive natural products are a potential source of new pharmaceuticals since they offer new modes of action and more specific activities. The use of derivatization also enables the optimal structure for their biological activity to be determined. In this study several epoxycurcuphenol derivatives were synthesized. The substitution pattern on the aromatic and oxirane rings was varied along with that at the benzylic position and the length of the side chain was altered. These changes were made in order to gain a deeper understanding of the structural requirements for activity. The biological activities of these compounds were evaluated on the human leukemia cell line Jurkat using an antiproliferative assay. The activity results and structural requirements are discussed.

Published
2012

40. Sesquiterpene Lactones as Allelochemicals

Author

Macías, Francisco A., primary, Fernández, Adriana, additional, Varela, Rosa M., additional, Molinillo, José M. G., additional, Torres, Ascensión, additional, and Alves, Pedro L. C. A., additional

Published
2006
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45. Aloe barbadensis: how a miraculous plant becomes reality.

Author

Chinchilla, Nuria, Carrera, Ceferino, Durán, Alexandra G., Macías, Mariola, Torres, Ascensión, and Macías, Francisco A.

Abstract

Aloe barbadensis Miller is a plant that is native to North and East Africa and has accompanied man for over 5,000 years. The aloe vera plant has been endowed with digestive, dermatological, culinary and cosmetic virtues. On this basis, aloe provides a range of possibilities for fascinating studies from several points of view, including the analysis of chemical composition, the biochemistry involved in various activities and its application in pharmacology, as well as from horticultural and economic standpoints. The use of aloe vera as a medicinal plant is mentioned in numerous ancient texts such as the Bible. This multitude of medicinal uses has been described and discussed for centuries, thus transforming this miracle plant into reality. A summary of the historical uses, chemical composition and biological activities of this species is presented in this review. The latest clinical studies involved in vivo and in vitro assays conducted with aloe vera gel or its metabolites and the results of these studies are reviewed. [ABSTRACT FROM AUTHOR]

Published
2013
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