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7. Relationship between sRAGE and eotaxin-3 with CRP in hypertensive patients at high cardiovascular risk

Author

Falcone, C, Buzzi, M, Bozzini, S, Boiocchi, C, D'Angelo, A, Schirinzi, S, Choi, J, Kilama, M, Esposito, C, Torreggiani, M, Mancia, G, Falcone, Colomba, Buzzi, Maria Paola, Bozzini, Sara, Boiocchi, Chiara, D'Angelo, Angela, Schirinzi, Sandra, Choi, Jasmine, Kilama, Michael Ochan, Esposito, Ciro, Torreggiani, Massimo, Mancia, Giuseppe, Falcone, C, Buzzi, M, Bozzini, S, Boiocchi, C, D'Angelo, A, Schirinzi, S, Choi, J, Kilama, M, Esposito, C, Torreggiani, M, Mancia, G, Falcone, Colomba, Buzzi, Maria Paola, Bozzini, Sara, Boiocchi, Chiara, D'Angelo, Angela, Schirinzi, Sandra, Choi, Jasmine, Kilama, Michael Ochan, Esposito, Ciro, Torreggiani, Massimo, and Mancia, Giuseppe

Abstract

Background: Cardiovascular disease (CVD) is the leading cause of death in Western countries and is highly prevalent in patients with kidney disease. Traditional risk factors for CVD often accompany kidney dysfunction, and chronic kidney disease per se is considered an additional risk factor. Risk stratification for CVD remains suboptimal even after the introduction of global risk assessment by various scores. This has prompted the search for novel markers of cardiovascular risk, and several biomarkers have been suggested as candidates, together with C-reactive protein (CRP). The objective of the present study was to investigate the relationship between novel biomarkers of vascular inflammation (soluble form of the receptor for advanced glycation end products [sRAGE] and eotaxin-3) with CRP in a population of hypertensive patients at high cardiovascular risk. Methods: Plasma sRAGE, high-sensitivity CRP (hs- CRP) and eotaxin-3 were measured in 399 hypertensive patients (265 men, mean age 58 ± 8 years)with diabetes mellitus, metabolic syndrome or organ damage. Results: Plasma concentrations of sRAGE, eotaxin-3 and hs-CRP were not different between diabetic and nondiabetic subjects. Univariate analysis showed that plasma levels of sRAGE and eotaxin-3 were not associated with hs-CRP in either subgroup. Conclusion: Our study confirms the robust and widely studied role of CRP as an important marker of vascular inflammation. We also postulate the possible involvement of sRAGE and eotaxin, 2 novel biomarkers, in CVDs. On the basis of our results, we can put forward the hypotheses that hs-CRP, s-RAGE and eotaxin are reliable but unrelated cardiovascular risk markers. © 2012 Società Italiana di Nefrologia - ISSN 1121-8428.

Published
2013

8. Pathophysiology and clinical studies in CKD 5D

Author

Raimann, J. G., primary, Gotch, F., additional, Keen, M., additional, Kotanko, P., additional, Levin, N. W., additional, Pierratos, A., additional, Lindsay, R., additional, Severova-Andreevska, G., additional, Trajceska, L., additional, Gelev, S., additional, Selim, G., additional, Sikole, A., additional, Yoon, S. Y., additional, Hwang, S. D., additional, Cho, D. K., additional, Cho, Y. H., additional, Moon, S. J., additional, Ribitsch, W., additional, Schreiner, P. J., additional, Uhlmann, M., additional, Schilcher, G., additional, Stadlbauer, V., additional, Horina, J. H., additional, Rosenkranz, A. R., additional, Schneditz, D., additional, Kiss, I., additional, Kerkovits, L., additional, Ambrus, C., additional, Kulcsar, I., additional, Szegedi, J., additional, Benke, A., additional, Borbas, B., additional, Ferenczi, S., additional, Hengsperger, M., additional, Kazup, S., additional, Nagy, L., additional, Nemeth, J., additional, Rozinka, A., additional, Szabo, T., additional, Szelestei, T., additional, Toth, E., additional, Varga, G., additional, Wagner, G., additional, Zakar, G., additional, Gergely, L., additional, Tisler, A., additional, Kiss, Z., additional, Sasaki, S., additional, Miyamato, M., additional, Nomura, A., additional, Koitabashi, K., additional, Nishiwaki, H., additional, Suzuki, T., additional, Uchida, D., additional, Kawarazaki, H., additional, Shibagaki, Y., additional, Kimura, K., additional, Libetta, C., additional, Martinelli, C., additional, Margiotta, E., additional, Borettaz, I., additional, Canevari, M., additional, Esposito, P., additional, Sepe, V., additional, Dal Canton, A., additional, Pateinakis, P., additional, Dimitriadis, C., additional, Papagianni, A., additional, Douma, S., additional, Efstratiadis, G., additional, Memmos, D., additional, Nelson, C. L., additional, Dunstan, P. J., additional, Zwiech, R., additional, Hasuike, Y., additional, Yanase, K., additional, Hamahata, S., additional, Nagai, T., additional, Yahiro, M., additional, Kaibe, S., additional, Kida, A., additional, Nagasawa, Y., additional, Kuragano, T., additional, Nakanishi, T., additional, Kim, J. S., additional, Yang, J. W., additional, Choi, S. O., additional, Han, B. G., additional, Chang, J. H., additional, Kim, A. J., additional, Kim, H. S., additional, Ro, H., additional, Jung, J. Y., additional, Lee, H. H., additional, Chung, W., additional, Tanaka, H., additional, Kita, T., additional, Okamoto, K., additional, Mikami, M., additional, Sakai, R., additional, Lojacono, E., additional, Votta, B., additional, Rampino, T., additional, Gregorini, M., additional, Amore, A., additional, Coppo, R., additional, ElSharkawy, M. M. S., additional, Kamel, M., additional, Elhamamsy, M., additional, Allam, S., additional, Ryu, J.-H., additional, Lee, S., additional, Hong, S. C., additional, Kim, S.-J., additional, Kang, D.-H., additional, Ryu, D.-R., additional, Choi, K. B., additional, Kiraz, T., additional, Yalcin, A., additional, Akay, M., additional, Sahin, G., additional, Musmul, A., additional, Kamijo, Y., additional, Horiuchi, H., additional, Iida, H., additional, Saito, K., additional, Furutera, R., additional, Ishibashi, Y., additional, Sidiropoulou, M., additional, Patsialas, S., additional, Angelopoulos, M., additional, Torreggiani, M., additional, Serpieri, N., additional, Arazzi, M., additional, Esposito, V., additional, Calatroni, M., additional, La Porta, E., additional, Catucci, D., additional, Montagna, G., additional, Semeraro, L., additional, Efficace, E., additional, Piazza, V., additional, Picardi, L., additional, Villa, G., additional, Esposito, C., additional, Kim, J. C., additional, Hwang, E., additional, Park, K., additional, Karakizlis, H., additional, Bohl, K., additional, Kortus-Goetze, B., additional, Dodel, R., additional, Hoyer, J., additional, Cinar, A., additional, Kazancioglu, R., additional, Isik, A. T., additional, Aydemir, E., additional, Gorcin, B., additional, Radic, J., additional, Ljutic, D., additional, Radic, M., additional, Kovacic, V., additional, Sain, M., additional, Dodig Curkovic, K., additional, Grzegorzewska, A. E., additional, Niepolski, L., additional, Sikora, J., additional, Jagodzinski, P., additional, Sowinska, A., additional, Sirolli, V., additional, Rossi, C., additional, Di Castelnuovo, A., additional, Felaco, P., additional, Amoroso, L., additional, Zucchelli, M., additional, Ciavardelli, D., additional, Sacchetta, P., additional, Urbani, A., additional, Arduini, A., additional, Bonomini, M., additional, Inoue, T., additional, Okano, K., additional, Tsuruta, Y., additional, Tsuchiya, K., additional, Akiba, T., additional, Nitta, K., additional, and Pajzderski, D., additional

Published
2013
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9. Immune and inflammatory mechanisms

Author

Castellano, G., primary, Cafiero, C., additional, Divella, C., additional, Sallustio, F., additional, Gigante, M., additional, Gesualdo, L., additional, Kirsch, A. H., additional, Smaczny, N., additional, Riegelbauer, V., additional, Sedej, S., additional, Hofmeister, A., additional, Stojakovic, T., additional, Brodmann, M., additional, Pilger, E., additional, Rosenkranz, A., additional, Eller, K., additional, Eller, P., additional, Meier, P., additional, Lucisano, S., additional, Arena, A., additional, Donato, V., additional, Fazio, M. R., additional, Santoro, D., additional, Buemi, M., additional, Wornle, M., additional, Ribeiro, A., additional, Koppel, S., additional, Pircher, J., additional, Czermak, T., additional, Merkle, M., additional, Rupanagudi, K., additional, Kulkarni, O. P., additional, Lichtnekert, J., additional, Darisipudi, M. N., additional, Mulay, S. R., additional, Schott, B., additional, Hartmann, G., additional, Anders, H.-J., additional, Pletinck, A., additional, Glorieux, G., additional, Schepers, E., additional, Van Landschoot, M., additional, Eloot, S., additional, Van Biesen, W., additional, Vanholder, R., additional, Castoldi, A., additional, Oliveira, V., additional, Amano, M., additional, Aguiar, C., additional, Caricilli, A., additional, Vieira, P., additional, Burgos, M., additional, Hiyane, M., additional, Festuccia, W., additional, Camara, N., additional, Djudjaj, S., additional, Rong, S., additional, Lue, H., additional, Bajpai, A., additional, Klinkhammer, B., additional, Moeller, M., additional, Floege, J., additional, Bernhagen, J., additional, Ostendorf, T., additional, Boor, P., additional, Ito, S., additional, Aoki, R., additional, Hamada, K., additional, Edamatsu, T., additional, Itoh, Y., additional, Osaka, M., additional, Yoshida, M., additional, Oliva, E., additional, Maritati, F., additional, Palmisano, A., additional, Alberici, F., additional, Buzio, C., additional, Vaglio, A., additional, Grabulosa, C., additional, Cruz, E., additional, Carvalho, J., additional, Manfredi, S., additional, Canziani, M., additional, Cuppari, L., additional, Quinto, B., additional, Batista, M., additional, Cendoroglo, M., additional, Dalboni, M., additional, Niemir, Z., additional, Swierzko, A., additional, Polcyn-Adamczak, M., additional, Cedzynski, M., additional, Sokolowska, A., additional, Szala, A., additional, Baudoux, T., additional, Hougardy, J.-M., additional, Pozdzik, A., additional, Antoine, M.-H., additional, Husson, C., additional, De Prez, E., additional, Nortier, J., additional, Ni, H.-F., additional, Chen, J.-F., additional, Zhang, M.-H., additional, Pan, M.-M., additional, Liu, B.-C., additional, Machcinska, M., additional, Bocian, K., additional, Korczak-Kowalska, G., additional, Tami Amano, M., additional, Andrade-Oliveira, V., additional, da Silva, M., additional, Miyagi, M. Y. S., additional, Olsen Camara, N., additional, Xu, L., additional, Jin, Y., additional, Zhong, F., additional, Liu, J., additional, Dai, Q., additional, Wang, W., additional, Chen, N., additional, Grosjean, F., additional, Tribioli, C., additional, Esposito, V., additional, Catucci, D., additional, Azar, G., additional, Torreggiani, M., additional, Merlini, G., additional, Esposito, C., additional, Fell, L. H., additional, Zawada, A. M., additional, Rogacev, K. S., additional, Seiler, S., additional, Fliser, D., additional, Heine, G. H., additional, Neprintseva, N., additional, Tchebotareva, N., additional, Bobkova, I., additional, Kozlovskaya, L., additional, Virzi, G. M., additional, Brocca, A., additional, de Cal, M., additional, Bolin, C., additional, Vescovo, G., additional, Ronco, C., additional, Fuchs, A., additional, Eidenschink, K., additional, Steege, A., additional, Fellner, C., additional, Bollheimer, C., additional, Gronwald, W., additional, Schroeder, J., additional, Banas, B., additional, Banas, M. C., additional, Luthe, A., additional, Seiler, S. S., additional, Rogacev, K., additional, Trimboli, D., additional, Graziani, G., additional, Haroche, J., additional, Lupica, R., additional, Cernaro, V., additional, Montalto, G., additional, Pettinato, G., additional, Cho, E., additional, Lee, J.-W., additional, Kim, M.-G., additional, Jo, S.-K., additional, Cho, W.-Y., additional, and kim, H.-K., additional

Published
2013
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10. Transplantation: clinical studies - A

Author

Yildirim, T., primary, Yilmaz, R., additional, Altindal, M., additional, Turkmen, E., additional, Arici, M., additional, Altun, B., additional, Erdem, Y., additional, Guliyev, O., additional, Erkmen Uyar, M., additional, Tutal, E., additional, Bal, Z., additional, Sezer, S., additional, Bal, U., additional, Say n, B., additional, Erdemir, B., additional, O'Rourke-Potowki, A., additional, Gauge, N., additional, Penny, H., additional, Cronin, A., additional, Frame, S., additional, Goldsmith, D. J., additional, Yagan, J. A., additional, Chandraker, A., additional, Velickovic Radovanovic, R. M., additional, Catic Djordjevic, A., additional, Mitic, B., additional, Stefanovic, N., additional, Cvetkovic, T., additional, Serpieri, N., additional, Grosjean, F., additional, Sileno, G., additional, Torreggiani, M., additional, Esposito, V., additional, Mangione, F., additional, Abelli, M., additional, Castoldi, F., additional, Catucci, D., additional, Esposito, C., additional, Dal Canton, A., additional, Vatazin, A. V., additional, Zulkarnaev, A. B., additional, Borst, C., additional, Liu, Y., additional, Thoning, J., additional, Tepel, M., additional, Libetta, C., additional, Margiotta, E., additional, Borettaz, I., additional, Canevari, M., additional, Martinelli, C., additional, Lainu, E., additional, Meloni, F., additional, Sepe, V., additional, Miguel Costa, R., additional, Vasquez Martul, E., additional, Reboredo, J., additional, Rivera, C., additional, Simonato, F., additional, Tognarelli, G., additional, Daidola, G., additional, Gallo, E., additional, Burdese, M., additional, Cantaluppi, V., additional, Biancone, L., additional, Segoloni, G. P., additional, Priora, M., additional, Messina, M., additional, Tamagnone, M., additional, Linsalata, A., additional, Lavacca, A., additional, Segoloni, G., additional, Zuidema, W., additional, Erdman, R., additional, van de Wetering, J., additional, Dor, F., additional, Roodnat, J., additional, Massey, E., additional, Timmerman, L., additional, IJzermans, J., additional, Weimar, W., additional, Sibley-Allen, C., additional, Hilton, R., additional, Moghul, M., additional, Burnapp, L., additional, Blake, G., additional, Koo, T. Y., additional, Park, J.-S., additional, Park, H. C., additional, Kim, G.-H., additional, Lee, C. H., additional, Oh, I. H., additional, Kang, C. M., additional, Hwang, J. K., additional, Park, S. C., additional, Choi, B. S., additional, Chun, H. J., additional, Kim, J. I., additional, Yang, C. W., additional, Moon, I. S., additional, Van Laecke, S., additional, Van Biesen, W., additional, Nagler, E. V., additional, Taes, Y., additional, Peeters, P., additional, Vanholder, R., additional, Pruthi, R., additional, Ravanan, R., additional, Casula, A., additional, Harber, M., additional, Roderick, P., additional, Fogarty, D., additional, Cho, A., additional, Shin, J.-h., additional, Jang, H. R., additional, Lee, J. E., additional, Huh, W., additional, Kim, D. J. K., additional, Oh, H. Y., additional, Kim, Y.-G., additional, Sancho Calabuig, A., additional, Gavela Martinez, E., additional, Kanter Berga, J., additional, Beltran Catalan, S., additional, Avila Bernabeu, A. I., additional, Pallardo Mateu, L. M., additional, Gonzalez, E., additional, Polanco, N., additional, Molina, M., additional, Gutierrez, E., additional, Garcia Puente, L., additional, Sevillano, A., additional, Morales, E., additional, Praga, M., additional, Andres, A., additional, Banasik, M., additional, Boratynska, M., additional, Koscielska-Kasprzak, K., additional, Bartoszek, D., additional, Myszka, M., additional, Zmonarski, S., additional, Nowakowska, B., additional, Wawrzyniak, E., additional, Halon, A., additional, Chudoba, P., additional, Klinger, M., additional, Rojas-Rivera, J., additional, Morales, J. M., additional, Egido, J., additional, Kopecky, C. M., additional, Haidinger, M., additional, Kaltenecker, C., additional, Antlanger, M., additional, Marsche, G., additional, Holzer, M., additional, Kovarik, J., additional, Werzowa, J., additional, Hecking, M., additional, Saemann, M. D., additional, Kim, J. M., additional, Koh, E. S., additional, Chung, B. H., additional, Kim, Y. S., additional, Krajewska, M., additional, Mazanowska, O., additional, Kaminska, D., additional, Zabinska, M., additional, Malkiewicz, B., additional, Patrzalek, D., additional, Sulowicz, J., additional, Szostek, S., additional, Wojas-Pelc, A., additional, Ignacak, E., additional, Sulowicz, W., additional, Bellizzi, V., additional, Calella, P., additional, Cupisti, A., additional, Capitanini, A., additional, D'Alessandro, C., additional, Giannese, D., additional, Camocardi, A., additional, Conte, G., additional, Barsotti, M., additional, Bilancio, G., additional, Luciani, R., additional, Locsey, L., additional, Seres, I., additional, Kovacs, D., additional, Asztalos, L., additional, Paragh, G., additional, Wohlfahrtova, M., additional, Balaz, P., additional, Rokosny, S., additional, Wohlfahrt, P., additional, Bartonova, A., additional, Viklicky, O., additional, Kers, J., additional, Geskus, R. B., additional, Meijer, L. J., additional, Bemelman, F., additional, ten Berge, I. J. M., additional, Florquin, S., additional, Hwang, J.-C., additional, Jiang, M.-Y., additional, Lu, Y.-H., additional, Weng, S.-F., additional, Testa, A., additional, Porto, G., additional, Sanguedolce, M., additional, Spoto, B., additional, Parlongo, R., additional, Pisano, A., additional, Enia, G., additional, Tripepi, G., additional, Zoccali, C., additional, Mamode, N., additional, Lennerling, A., additional, Citterio, F., additional, Van Assche, K., additional, Sterckx, S., additional, Frunza, M., additional, Jung, H., additional, Pascalev, A., additional, Johnson, R., additional, Loven, C., additional, Soleymanian, T., additional, Keyvani, H., additional, Jazayeri, S. M., additional, Fazeli, Z., additional, Ghamari, S., additional, Mahabadi, M., additional, Chegeni, V., additional, Najafi, I., additional, Ganji, M. R., additional, Meys, K. M. E., additional, Groothoff, J. W., additional, Jager, K., additional, Schaefer, F., additional, Tonshoff, B., additional, Mota, C., additional, Cransberg, K., additional, van Stralen, K., additional, Gurluler, E., additional, Gures, N., additional, Alim, A., additional, Gurkan, A., additional, Cakir, U., additional, Berber, I., additional, Caluwe, R., additional, Nagler, E., additional, Van Vlem, B., additional, Betkowska-Prokop, A., additional, Kuzniewski, M., additional, Krzanowski, M., additional, Masson, I., additional, Flamant, M., additional, Maillard, N., additional, Cavalier, E., additional, Moranne, O., additional, Alamartine, E., additional, Mariat, C., additional, Delanaye, P., additional, Canas Sole, L. L., additional, Iglesias Alvarez, E., additional, Pastor, M. C. M. C., additional, Moreno Flores, F. F., additional, Abujder, V. V., additional, Graterol, F. F., additional, Bonet Sol, J. J., additional, Lauzurica Valdemoros, R. R., additional, Yoshikawa, M., additional, Kitamura, K., additional, Nakai, K., additional, Goto, S., additional, Fujii, H., additional, Ishimura, T., additional, Takeda, M., additional, Fujisawa, M., additional, Nishi, S., additional, Prasad, N., additional, Gurjer, D., additional, Bhadauria, D., additional, Gupta, A., additional, Sharma, R., additional, Kaul, A., additional, Cybulla, M., additional, West, M., additional, Nicholls, K., additional, Torras, J., additional, Sunder-Plassmann, G., additional, Feriozzi, S., additional, Lo, S., additional, Wong, P. Y. H., additional, Ip, D., additional, Wong, C. K., additional, Chow, V. C. C., additional, Mo, S. K. L., additional, Molnar, M., additional, Ujszaszi, A., additional, Czira, M. E., additional, Novak, M., additional, Mucsi, I., additional, Cruzado, J. M., additional, Coelho, S., additional, Porta, N., additional, Bestard, O., additional, Melilli, E., additional, Taco, O., additional, Rivas, I., additional, Grinyo, J., additional, Pouteau, L.-M., additional, N'Guyen, J.-M., additional, Hami, A., additional, Hourmant, M., additional, Ghahramani, N., additional, Karparvar, Z., additional, Shadrou, S., additional, Ghahramani, M., additional, Fauvel, J. P., additional, Hadj-Aissa, A., additional, Buron, F., additional, Morelon, E., additional, Ducher, M., additional, Heine, C., additional, Glander, P., additional, Neumayer, H.-H., additional, Budde, K., additional, Liefeldt, L., additional, Montero, N., additional, Webster, A. C., additional, Royuela, A., additional, Zamora, J., additional, Crespo, M., additional, Pascual, J., additional, Adema, A. Y., additional, van Dorp, W. T. H., additional, Mallat, M. J. K., additional, de Fijter, H. W., additional, Hong, Y. A., additional, Park, C. W., additional, Kim, Y.-S., additional, Suleymanlar, G., additional, Uzundurukan, Z., additional, Kapuagas , A., additional, Sencan, I., additional, Akdag, R., additional, Torio, A., additional, Mas, V., additional, Perez-Saez, M. J., additional, Mir, M., additional, Faura, A., additional, Montes-Ares, O., additional, Checa, M. D., additional, Sawinski, D., additional, Trofe-Clark, J., additional, Sparkes, T., additional, Patel, P., additional, Goral, S., additional, Bloom, R., additional, Kim, H. J., additional, Park, S. J., additional, Kim, T. H., additional, Kim, Y. W., additional, Kim, Y. H., additional, Kang, S. W., additional, Abdel Halim, M., additional, Gheith, O., additional, Al-Otaibi, T., additional, Mosaad, A., additional, Awadeen, W., additional, Said, T., additional, Nair, P., additional, and Nampoory, M. R. N., additional

Published
2013
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14. Hypertension

Author

Shin, S. J., primary, Rhee, M.-Y., additional, Lim, C., additional, Lavoz, C., additional, Rodrigues-Di;ez, R., additional, Rayego-Mateos, S., additional, Benito-Martin, A., additional, Rodrigues-Diez, R., additional, Alique, M., additional, Ortiz, A., additional, Mezzano, S., additional, Ruiz-Ortega, M., additional, Axelsson, J., additional, Rippe, A., additional, Sverrisson, K., additional, Rippe, B., additional, Calo, L., additional, Dal Maso, L., additional, Pagnin, E., additional, Caielli, P., additional, Spanos, G., additional, Kalaitzidis, R., additional, Karasavvidou, D., additional, Pappas, K., additional, Balafa, O., additional, Siamopoulos, K., additional, Fang, T.-C., additional, Lee, T. J. F., additional, Pappas, E., additional, Ermeidi, E., additional, Tatsioni, A., additional, Blazquez-Medela, A., additional, Garcia-Sanchez, O., additional, Quiros, Y., additional, Lopez-Hernandez, F. J., additional, Lopez-Novoa, J. M., additional, Martinez-Salgado, C., additional, Wu, H.-Y., additional, Peng, Y.-S., additional, Hung, K.-Y., additional, Tsai, T.-J., additional, Tu, Y.-K., additional, Chien, K.-L., additional, Larsen, T., additional, Mose, F. H., additional, Hansen, A. B., additional, Pedersen, E. B., additional, Quiroz, Y., additional, Rivero, M., additional, Yaguas, K., additional, Rodriguez-Iturbe, B., additional, Xydakis, D., additional, Sfakianaki, M., additional, Petra, C., additional, Maragaki, E., additional, Antonaki, E., additional, Krasoudaki, E., additional, Kostakis, K., additional, Stylianou, K., additional, Papadogiannakis, A., additional, Sagliker, Y., additional, Paylar, N., additional, Heidland, A., additional, Keck, A., additional, Erek, R., additional, Kolasin, P., additional, S Ozkaynak, P., additional, Sagliker, H. S., additional, Gokcay, I., additional, Ritz, E., additional, Koleganova, N., additional, Gross-Weissmann, M.-L., additional, Piecha, G., additional, Reinecke, N., additional, Marquez Cunha, T., additional, M . S. Higa, E., additional, Pfeferman Heilberg, I., additional, Neder, J. A., additional, Nishiura, J. L., additional, Silva Almeida, W., additional, Schor, N., additional, Tapia, E., additional, Sanchez-Lozada, L. G., additional, Cristobal, M., additional, Soto, V., additional, Garci;a-Arroyo, F., additional, Monroy-Sanchez, F., additional, Madero, M., additional, Johnson, R., additional, Kim, S. M., additional, Yang, S. H., additional, Kim, Y. S., additional, Karanovic, S., additional, Fistrek, M., additional, Kos, J., additional, Pecin, I., additional, Premuzic, V., additional, Abramovic, M., additional, Matijevic, V., additional, Cvoriscec, D., additional, Cvitkovic, A., additional, Knezevic, M., additional, Bitunjac, M., additional, Laganovic, M., additional, Jelakovic, B., additional, Liu, F., additional, Wu, M., additional, Fu, P., additional, Klok Matthesen, S., additional, Guldager Lauridsen, T., additional, Vase, H., additional, Gjorup Holland, P., additional, Nykjaer, K. M., additional, Nielsen, S., additional, Bjerregaard Pedersen, E., additional, Montero, M. J., additional, Vink, E., additional, Willemien, V., additional, Michiel, V., additional, Wilko, S., additional, Evert-Jan, V., additional, Blankestijn, P., additional, Zerbi, S., additional, Pedrini, L. A., additional, Zbroch, E., additional, Malyszko, J., additional, Koc-Zorawska, E., additional, Mysliwiec, M., additional, Quelhas-Santos, J., additional, Serrao, P., additional, Soares-Silva, I., additional, Tang, L., additional, Sampaio-Maia, B., additional, Desir, G., additional, Pestana, M., additional, Elsurer, R., additional, Demir, T., additional, Celik, G., additional, Yavas, M., additional, Yavas, O., additional, Murphy, M., additional, Jacquillet, G., additional, Unwin, R. J., additional, Chichger, H., additional, Shirley, D. G., additional, Caraba, A., additional, Andreea, M., additional, Corina, S., additional, Ioan, R., additional, Nowicki, M., additional, Bobik, M., additional, Pawelec, A., additional, Lacisz, J., additional, Zapala, A., additional, Bryc, K., additional, Esposito, C., additional, Scaramuzzi, M. L., additional, Manini, A., additional, Torreggiani, M., additional, Beneventi, F., additional, Spinillo, A., additional, Grosjean, F., additional, Fasoli, G., additional, Dal Canton, A., additional, Christos, C., additional, Bernhard M.W., S., additional, Martin, N., additional, Jan, K., additional, Claus, M., additional, Leyla, R., additional, Jan, B., additional, Ulrich, K., additional, Hermann, H., additional, Menne, J., additional, Pavicevic, M., additional, Markovic, S., additional, and Igrutinovic, Z., additional

Published
2012
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15. AKI - Experimental

Author

Kaynar, K., primary, Kaynar, K., additional, Ersoz, S., additional, Aliyazioglu, R., additional, Uzun, A., additional, Ulusoy, S., additional, Al, S., additional, Ozkan, G., additional, Cansiz, M., additional, Bertocchio, J.-P., additional, Lancon, J., additional, El Moghrabi, S., additional, Galmiche, G., additional, Duong Van Huyen, J.-P., additional, Rieu, P., additional, Jaisser, F., additional, Albertoni, G., additional, Andrade, S., additional, Barreto, J. A., additional, Borges, F., additional, Schor, N., additional, Ho, W.-Y., additional, Chen, S.-H., additional, Tseng, C.-J., additional, Bienholz, A., additional, Feldkamp, T., additional, Weinberg, J. M., additional, Suller Garcia, J., additional, Naves, M., additional, Aparecida Reis, L., additional, Simoes, M. d. J., additional, S Almeida, W., additional, Moreau Longo, V., additional, Segreto, H. R. C., additional, Ghoneim, A., additional, Elkholy, A., additional, Medhat Abbas, T., additional, El Hadeedy, M., additional, Elhusseini, F., additional, Elessawey, B., additional, Eltanaihy, E., additional, Lotfy, A., additional, Eldesoky, S., additional, Sheashaa, H., additional, Sobh, M., additional, Minning, D. M., additional, Warnock, D., additional, Mohamed, A. S., additional, Wirthlin, J. B., additional, Chintalacharuvu, S. R., additional, Boone, L., additional, Brenner, R. M., additional, Santina Christo, J., additional, Dos Santos Passos, C., additional, Rene de Alencar, D., additional, De Braganca, A. C., additional, Canale, D., additional, Goncalves, J. G., additional, Brandao, T. P. B., additional, Shimizu, M. H. M., additional, Volpini, R. A., additional, Seguro, A. C., additional, Andrade, L., additional, Lee, J.-W., additional, Kim, H. K., additional, Cho, W. Y., additional, Jo, S.-K., additional, Cho, E., additional, Hocherl, K., additional, Schmidt, C., additional, Mulay, S. R., additional, Kulkarni, O. P., additional, Rupanagudi, K. V., additional, Migliorini, A., additional, Liapis, H., additional, Anders, H.-J., additional, Pevzner, I., additional, Chupyrkina, A., additional, Plotnikov, E., additional, Zorov, D., additional, Lopez-Novoa, J.-M., additional, Eleno, N., additional, Perez-Barriocanal, F., additional, Arevalo, M., additional, Docherty, N., additional, Castellano, G., additional, Divella, C., additional, Loverre, A., additional, Stasi, A., additional, Curci, C., additional, Rossini, M., additional, Ditonno, P., additional, Battaglia, M., additional, Daha, M. R., additional, Van Kooten, C., additional, Gesualdo, L., additional, Schena, F. P., additional, Grandaliano, G., additional, Tsuda, H., additional, Kawada, N., additional, Iwatani, H., additional, Moriyama, T., additional, Takahara, S., additional, Rakugi, H., additional, Isaka, Y., additional, Schley, G., additional, Kalucka, J., additional, Klanke, B., additional, Jantsch, J., additional, Olbrich, S., additional, Baumgartl, J., additional, Amann, K., additional, Eckardt, K.-U., additional, Weidemann, A., additional, Dolgolikova, A., additional, Pilotovich, V., additional, Ivanchik, G., additional, Shved, I., additional, Banki, N. F., additional, Antal, Z., additional, Hosszu, A., additional, Koszegi, S., additional, Vannay, A., additional, Wagner, L., additional, Prokai, A., additional, Muller, V., additional, Szabo, A. J., additional, Fekete, A., additional, Farrag, S., additional, Abulasrar, S., additional, Salama, , M., additional, Amin, M., additional, Ali, A., additional, Rubera, I., additional, Duranton, C., additional, Cougnon, M., additional, Melis, N., additional, Tauc, M., additional, Jankauskas, S., additional, Morosanova, M., additional, Pulkina, N., additional, Zorova, L., additional, Shin, Y. T., additional, Kim, S. S., additional, Chang, Y. K., additional, Choi, D. E., additional, Na, K.-R., additional, Lee, K. W., additional, Choi, J.-Y., additional, Jin, D.-C., additional, Cha, J.-H., additional, Schneider, R., additional, Betz, B., additional, Meusel, M., additional, Held, C., additional, Wanner, C., additional, Gekle, M., additional, Sauvant, C., additional, Pisani, A., additional, Rossano, R., additional, Mancini, A., additional, Arfian, N., additional, Yagi, K., additional, Nakayama, K., additional, Ali, H., additional, Mayasari, D. S., additional, Purnomo, E., additional, Emoto, N., additional, Efrati, S., additional, Berman, S., additional, Abu Hamad, R., additional, Weissgarten, J., additional, Scherbaum, C. R., additional, Allam, R., additional, Lichtnekert, J., additional, Darisipudi, M. N., additional, Hagele, H., additional, Hohenstein, B., additional, Hugo, C., additional, Schaefer, L., additional, Corsi, C., additional, Ferramosca, E., additional, Grandi, E., additional, Pisoni, L., additional, Rivolta, I., additional, Dalpozzo, B., additional, Hoxha, E., additional, Severi, S., additional, Santoro, A., additional, Laurent, M., additional, Cedric, R., additional, Dominique, C., additional, Sophie, V., additional, Nochy, D., additional, Loic, G., additional, Patrice, C., additional, Chantal, J., additional, Marie-Christine, V., additional, Alexandre, H., additional, Eric, R., additional, Cantaluppi, V., additional, Medica, D., additional, Quercia, A. D., additional, Figliolini, F., additional, Dellepiane, S., additional, Randone, O., additional, Segoloni, G. P., additional, Camussi, G., additional, Ahn, B.-H., additional, Kim, S. H., additional, Yasue Saito Miyagi, M., additional, Camara, N., additional, Cerqueira Leite Seelaender, M., additional, Maceratesi Enjiu, L., additional, Estler Rocha Guilherme, P., additional, Pisciottano, M., additional, Hiyane, M., additional, Yuri Hayashida, C., additional, De Andrade Oliveira, V., additional, Olsen Saraiva Camara, N., additional, Tami Amano, M., additional, Sancho-Martinez, S. M., additional, Sanchez-Juanes, F., additional, Vicente, L., additional, Gonzalez-Buitrago, J. M., additional, Morales, A. I., additional, Lopez-Novoa, J. M., additional, Lopez-Hernandez, F. J., additional, Chen, J.-S., additional, Chang, L.-C., additional, Chen, C.-C., additional, Park, M. Y., additional, Choi, S. J., additional, Kim, J. G., additional, Hwang, S. D., additional, Vicente-Vicente, L., additional, Ferreira, L., additional, Prieto, M., additional, Garcia-Sanchez, O., additional, Sevilla, M. A., additional, Lopez-Novoa, F. J., additional, Christoph, K., additional, Kuper, C., additional, Maria-Luisa, F., additional, Franz-Xaver, B., additional, Neuhofer, W., additional, Vervaet, B., additional, Le Clef, N., additional, Verhulst, A., additional, D'haese, P., additional, Tanaka, T., additional, Yamaguchi, J., additional, Eto, N., additional, Kojima, I., additional, Fujita, T., additional, Nangaku, M., additional, Wystrychowski, A., additional, Wystrychowski, G., additional, Obuchowicz, E., additional, Grzeszczak, W., additional, Wiecek, A., additional, Esposito, C., additional, Torreggiani, M., additional, Castoldi, F., additional, Migotto, C., additional, Serpieri, N., additional, Grosjean, F., additional, Manini, A., additional, Pertile, E., additional, and Dal Canton, A., additional

Published
2012
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16. Diabetes - Experimental

Author

Kang, K. P., primary, Lee, J. E., additional, Lee, A. S., additional, Jung, Y. J., additional, Lee, S., additional, Park, S. K., additional, Kim, W., additional, Pokrywczynska, M., additional, Jundzill, A., additional, Krzyzanowska, S., additional, Flisinski, M., additional, Brymora, A., additional, Bodnar, M., additional, Deptula, A., additional, Marszalek, A., additional, Manitius, J., additional, Drewa, T., additional, Kloskowski, T., additional, Grosjean, F., additional, Esposito, V., additional, Torreggiani, M., additional, Esposito, C., additional, Zheng, F., additional, Vlassara, H., additional, Striker, G., additional, Michael, S., additional, Viswanathan, P., additional, Ganesh, R., additional, Kimachi, M., additional, Nishio, S., additional, Nakazawa, D., additional, Ishikawa, Y., additional, Toyoyama, T., additional, Satou, A., additional, Nakagaki, T., additional, Shibasaki, S., additional, Atumi, T., additional, Gattone, V., additional, Peterson, R., additional, Zimmerman, K., additional, Mega, C., additional, Reis, F., additional, Teixeira de Lemos, E., additional, Vala, H., additional, Fernandes, R., additional, Oliveira, J., additional, Teixeira, F., additional, Niculae, A., additional, Checherita, I.-A., additional, Ciocalteu, A., additional, Hamano, Y., additional, Udagawa, Y., additional, Ueda, Y., additional, Yokosuka, O., additional, Ogawa, M., additional, Satoh, M., additional, Kidokoro, K., additional, Nagasu, H., additional, Nishi, Y., additional, Ihoriya, C., additional, Kadoya, H., additional, Yada, T., additional, Channon, K. M., additional, Sasaki, T., additional, Kashihara, N., additional, Nyengaard, J. R., additional, Razga, Z., additional, Hartono, S., additional, Knudsen, B., additional, Grande, J., additional, Watanabe, M., additional, Ito, K., additional, Abe, Y., additional, Ogahara, S., additional, Nakashima, H., additional, Sato, T., additional, Saito, T., additional, Shin, Y. T., additional, Choi, D. E., additional, Na, K.-R., additional, Chang, Y. K., additional, Kim, S. S., additional, Lee, K. W., additional, Mace, C., additional, Chugh, S., additional, Clement, L., additional, Tomochika, M., additional, Seiji, H., additional, Toshio, M., additional, Tetsuya, K., additional, Takao, K., additional, Jaen, J. C., additional, Sullivan, T. J., additional, Miao, Z., additional, Zhao, N., additional, Berahovich, R., additional, Krasinski, A., additional, Powers, J. P., additional, Ertl, L., additional, Schall, T. J., additional, Han, S. Y., additional, Sun, H.-K., additional, Han, K. H., additional, Kim, H.-S., additional, Ahn, S.-H., additional, Kokeny, G., additional, Gasparics, A., additional, Fang, L., additional, Rosivall, L., additional, Sebe, A., additional, Banki, N. F., additional, Fekete, A., additional, Wagner, L., additional, Ver, A., additional, Degrell, P., additional, Prokai, A., additional, George, R., additional, Szabo, A., additional, Baylis, C., additional, Vannay, A., additional, Tulassay, T., additional, Chollet, C., additional, Hus-Citharel, A., additional, Caron, N., additional, Bouby, N., additional, Silva, K., additional, Rampaso, R., additional, Luiz, R., additional, De Angelis, K., additional, Mostarda, C. T., additional, Abreu, N., additional, Irigoyen, M. C., additional, Schor, N., additional, Montemor, J., additional, Higa, E. M. S., additional, Nakayama, Y., additional, Fukami, K., additional, Obara, N., additional, Ando, R., additional, Kaida, Y., additional, Ueda, S., additional, Yamagishi, S.-I., additional, Okuda, S., additional, Qin, Q., additional, Wang, Z., additional, Niu, J., additional, Xu, W., additional, Qiao, Z., additional, Qi, W., additional, Gu, Y., additional, Zitman-Gal, T., additional, Golan, E., additional, Green, J., additional, Pasmanik-Chor, M., additional, Oron-Karni, V., additional, Bernheim, J., additional, Benchetrit, S., additional, Tang, R.-N., additional, Wu, M., additional, Gao, M., additional, Liu, H., additional, Zhang, X.-L., additional, and Liu, B. C., additional

Published
2012
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17. Diabetes / Basic research

Author

Nakatani, S., primary, Wei, M., additional, Ishimura, E., additional, Kakehashi, A., additional, Mori, K., additional, Inaba, M., additional, Wanibuchi, H., additional, Li, Y., additional, Liu, J., additional, Wang, B., additional, Liu, M., additional, Chi, Y., additional, Marquez, E., additional, Riera, M., additional, Rigol, J., additional, Pascual, J., additional, Soler, M. J., additional, Grosjean, F., additional, Esposito, V., additional, Torreggiani, M., additional, Madek, J. M., additional, Williams, V. A., additional, Zheng, F., additional, Vlassara, H., additional, Jepsen, K. J., additional, Striker, G. E., additional, Yuan, Y., additional, Zhao, L., additional, Chen, Y., additional, Moorhead, J., additional, Varghese, Z., additional, Sun, Z., additional, Ruan, X., additional, Kuno, Y., additional, Iyoda, M., additional, Shibata, T., additional, Hirai, Y., additional, and Akizawa, T., additional

Published
2011
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18. Acute kidney injury - Experimental models

Author

Nagasaki, Y., primary, Yoshitomi, T., additional, Hirayama, A., additional, Schock-Kusch, D., additional, Xie, Q., additional, Shulhevich, Y., additional, Hesser, J., additional, Stsepankou, S., additional, Koenig, S., additional, Heinrich, R., additional, Pill, J., additional, Gretz, N., additional, Efrati, S., additional, Berman, S., additional, Abu-Hamad, R., additional, Siman-Tov, Y., additional, Weissgarten, J., additional, Kimura, T., additional, Takabatake, Y., additional, Takahashi, A., additional, Kaimori, J.-y., additional, Matsui, I., additional, Namba, T., additional, Kitamura, H., additional, Niimura, F., additional, Matsusaka, T., additional, Rakugi, H., additional, Isaka, Y., additional, Ito, K., additional, Watanabe, M., additional, Nakashima, H., additional, Abe, Y., additional, Ifuku, M., additional, Nishimura, S., additional, Saito, T., additional, Mulay, S. R., additional, Thomasova, D., additional, Ryu, M., additional, Anders, H.-J., additional, Nakayama, Y., additional, Ueda, S., additional, Yamagishi, S.-i., additional, Ando, R., additional, Kaida, Y., additional, Iwatani, R., additional, Fujimi, A., additional, Fukami, K., additional, Okuda, S., additional, Shin, Y. T., additional, Jeong, J. Y., additional, Jang, W. I., additional, Chung, S., additional, Choi, D. E., additional, Na, K. R., additional, Lee, K. W., additional, Mugitani, N., additional, Shimizu, Y., additional, Satake, K., additional, Suzuki, Y., additional, Horikoshi, S., additional, Tomino, Y., additional, Schneider, R., additional, Meusel, M., additional, Betz, B., additional, Wanner, C., additional, Koepsell, H., additional, Sauvant, C., additional, Dursun, B., additional, Abban, G., additional, Kucukatay, V., additional, Tufan, L., additional, Dodurga, Y., additional, Guclu, A., additional, Gok, D., additional, Vicente-Vicente, L., additional, Sanchez-Gonzalez, P. D., additional, Prieto, M., additional, Lopez-Novoa, J. M., additional, Lopez-Hernandez, F. J., additional, Morales, A. I., additional, Torres, A., additional, Dnyanmote, A., additional, Wu, W., additional, Nigam, S., additional, Wystrychowski, A., additional, Wystrychowski, W., additional, Kolodziejczyk, A., additional, Obuchowicz, E., additional, Wiecek, A., additional, Reis, L. A., additional, Borges, F. T., additional, Simoes, M. d. J., additional, Schor, N., additional, Mesnard, L., additional, Rafat, C., additional, Vandermeersch, S., additional, Nochy, D., additional, Garcon, L., additional, Callard, P., additional, Jouanneau, C., additional, Verpont, M.-C., additional, Hertig, A., additional, Rondeau, E., additional, Grosjean, F., additional, Torreggiani, M., additional, Esposito, V., additional, Mangione, F., additional, Serpieri, N., additional, Villa, L., additional, Sileno, G., additional, Marchi, G., additional, Fasoli, G., additional, Esposito, C., additional, Dal Canton, A., additional, Sancho-Martinez, S., additional, Striker, G., additional, Vlassara, H., additional, Zheng, F., additional, Park, D. J., additional, Kim, J. H., additional, Jung, M. H., additional, Seo, J. W., additional, Kim, H.-j., additional, Chang, S.-H., additional, Han, B.-G., additional, Yang, J.-W., additional, Yu, J.-M., additional, Choi, S.-O., additional, Christo, J. S., additional, Rusai, K., additional, Prokai, A., additional, Szebeni, B., additional, Meszaros, K., additional, Fekete, A., additional, Treszl, A., additional, Vannay, A., additional, Muller, V., additional, Reusz, G., additional, Heemann, U., additional, Tulassay, T., additional, Lutz, J., additional, Szabo, A. J., additional, Ranghino, A., additional, Bruno, S., additional, Grange, C., additional, Dolla, C., additional, Cantaluppi, V., additional, Biancone, L., additional, Tetta, C., additional, Segoloni, G. P., additional, Camussi, G., additional, Pinto, V., additional, Teixeira, V., additional, Almeida, W., additional, Fujikura, T., additional, Sun, Y., additional, Iwakura, T., additional, Yasuda, H., additional, Fujigaki, Y., additional, Simone, S., additional, Rascio, F., additional, Loverre, A., additional, Cosola, C., additional, Cariello, M., additional, Castellano, G., additional, Ditonno, P., additional, Schena, F. P., additional, Gesualdo, L., additional, Grandaliano, G., additional, Pertosa, G., additional, Choi, J.-Y., additional, Kim, J., additional, Jin, D.-C., additional, Cha, J.-H., additional, Kaynar, K., additional, Aliyazicioglu, R., additional, Ersoz, S., additional, Ulusoy, S., additional, Al, S., additional, Ozkan, G., additional, Cansiz, M., additional, Fuchs, T. C., additional, Emde, B., additional, Czasch, S., additional, von Landenberg, F., additional, Hewitt, P., additional, Abu-Salah, N., additional, Bishara, B., additional, Awad, H., additional, Ghrayeb, N., additional, Assady, S., additional, Armaly, Z., additional, Better, O., additional, and Abassi, Z., additional

Published
2011
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20. Effects of Sirolimus on Human Mesangial Cells

Author

Esposito, C., primary, Valentino, R., additional, Villa, L., additional, Serpieri, N., additional, Mangione, F., additional, Grosjean, F., additional, Esposito, V., additional, Castoldi, F., additional, Sileno, G., additional, Montagna, F., additional, Maggi, N., additional, Torreggiani, M., additional, Marchi, G., additional, and Dal Canton, A., additional

Published
2010
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23. « Ce qui me gêne, ce n'est pas mon âge... ». Diagnostic de glomérulonéphrite à dépôt de C3 sur mutation hétérozygote du facteur H chez une femme de 96 ans.

Author

Boud'hors, C., Milon, V., Coindre, J.P., Torreggiani, M., Croue, A., Fremeaux-Bacchi, V., Piccoli, G., and Wacrenier, S.

Abstract

Copyright of Néphrologie & Thérapeutique is the property of John Libbey Eurotext Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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2021
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25. Current management of hyperkalemia in non-dialysis CKD: Longitudinal study of patients receiving stable nephrology care

Author

Massimo Torreggiani, Giorgina Barbara Piccoli, Luca Apicella, Roberto Minutolo, Domenico Giannese, Giuseppe Conte, Paolo Chiodini, Vincenzo Bellizzi, Michele Provenzano, Luca De Nicola, Biagio Di Iorio, Carlo Garofalo, Domenico Santoro, Adamasco Cupisti, Silvio Borrelli, Vincenzo Calabrese, Borrelli, S., De Nicola, L., Minutolo, R., Conte, G., Chiodini, P., Cupisti, A., Santoro, D., Calabrese, V., Giannese, D., Garofalo, C., Provenzano, M., Bellizzi, V., Apicella, L., Piccoli, G. B., Torreggiani, M., and Di Iorio, B. R.

Subjects
Nephrology, Male, Longitudinal study, Hyperkalemia, medicine.medical_treatment, 030232 urology & nephrology, Longitudinal Studie, 030204 cardiovascular system & hematology, Gastroenterology, RAASI, chemistry.chemical_compound, 0302 clinical medicine, CKD, Diet, Potassium, Aged, Bicarbonates, Buffers, Diuretics, Female, Follow-Up Studies, Humans, Longitudinal Studies, Middle Aged, Renal Insufficiency, Chronic, Renal Insufficiency, Chronic, Nutrition and Dietetics, Bicarbonate, Current management, medicine.symptom, lcsh:Nutrition. Foods and food supply, Buffer, Human, medicine.medical_specialty, Urinary system, lcsh:TX341-641, Article, Follow-Up Studie, 03 medical and health sciences, Internal medicine, Diabetes mellitus, medicine, Diuretic, Dialysis, business.industry, medicine.disease, chemistry, business, Food Science
Abstract

Background: No study has explored the limitations of current long-term management of hyperkalemia (HK) in outpatient CKD clinics. Methods: We evaluated the association between current therapeutic options and control of serum K (sK) during 12-month follow up in ND-CKD patients stratified in four groups by HK (sK ≥ 5.0 mEq/L) at baseline and month 12: Absent (no-no), Resolving (yes-no), New Onset (no-yes), Persistent (yes-yes). Results: We studied 562 patients (age 66.2 ± 14.5 y, 61% males, eGFR 39.8 ± 21.8 mL/min/1.73 m2, RAASI 76.2%). HK was “absent” in 50.7%, “resolving” in 15.6%, “new onset” in 16.6%, and “persistent” in 17.1%. Twenty-four hour urinary measurements testified adherence to nutritional recommendations in the four groups at either visit. We detected increased prescription from baseline to month 12 of bicarbonate supplements (from 5.0 to 14.1%, p &lt, 0.0001), K-binders (from 2.0 to 7.7%, p &lt, 0.0001), and non-K sparing diuretics (from 34.3 to 41.5%, p &lt, 0.001), these changes were consistent across groups. Similar results were obtained when using higher sK level (≥5.5 mEq/L) to stratify patients. Mixed-effects regression analysis showed that higher sK over time was associated with eGFR &lt, 60, diabetes, lower serum bicarbonate, lower use of non-K sparing diuretics, bicarbonate supplementation, and K-binder use. Treatment-by-time interaction showed that sK decreased in HK patients given bicarbonate (p = 0.003) and K-binders (p = 0.005). Conclusions: This observational study discloses that one-third of ND-CKD patients under nephrology care remain with or develop HK during a 12-month period despite low K intake and increased use of sK-lowering drugs.

Published
2021

26. Smile! (Life will be better)

Author

Giuseppe Sileno, Marco Colucci, Ciro Esposito, Massimo Torreggiani, Vittoria Esposito, Fabrizio Grosjean, Silvio Abati, Esposito, V., Sileno, G., Abati, S., Colucci, M., Torreggiani, M., Grosjean, F., and Esposito, C.

Subjects
Nephrology, Advere events, medicine.medical_specialty, business.industry, General surgery, Gingival hypertrophy, Kidney transplant, Kidney Transplantation, Internal medicine, Adverse events, Gingival Hyperplasia, medicine, Cyclosporine, Gingival, Humans, business, Nephrology Pictures, Immunosuppressive Agents
Published
2020

27. Relationship between sRAGE and eotaxin-3 with CRP in hypertensive patients at high cardiovascular risk

Author

Colomba Falcone, Maria Paola Buzzi, Sara Bozzini, Chiara Boiocchi, Angela D’Angelo, Sandra Schirinzi, Jasmine Choi, Michael Ochan Kilama, Ciro Esposito, Massimo Torreggiani, Giuseppe Mancia, TALENT Investigators, Falcone, C, Buzzi, M, Bozzini, S, Boiocchi, C, D'Angelo, A, Schirinzi, S, Choi, J, Kilama, M, Esposito, C, Torreggiani, M, and Mancia, G

Subjects
Nephrology, Adult, Male, medicine.medical_specialty, Population, Receptor for Advanced Glycation End Products, Gastroenterology, Risk Assessment, Diabetes mellitus, Internal medicine, medicine, Diabetes Mellitus, Humans, Renal Insufficiency, Risk factor, Receptors, Immunologic, education, Aged, Metabolic Syndrome, education.field_of_study, biology, business.industry, Chemokine CCL26, C-reactive protein, Diabetes Mellitu, Biomarker, Glucose Tolerance Test, Middle Aged, medicine.disease, Eotaxin-3, Uric Acid, hs-CRP, Endocrinology, C-Reactive Protein, Chemokines, CC, Creatinine, Receptor for Advanced Glycation End Product, Hypertension, biology.protein, Female, Metabolic syndrome, business, Risk assessment, Biomarkers, sRAGE, Human, Kidney disease
Abstract

Background: Cardiovascular disease (CVD) is the leading cause of death in Western countries and is highly prevalent in patients with kidney disease. Traditional risk factors for CVD often accompany kidney dysfunction, and chronic kidney disease per se is considered an additional risk factor. Risk stratification for CVD remains suboptimal even after the introduction of global risk assessment by various scores. This has prompted the search for novel markers of cardiovascular risk, and several biomarkers have been suggested as candidates, together with C-reactive protein (CRP). The objective of the present study was to investigate the relationship between novel biomarkers of vascular inflammation (soluble form of the receptor for advanced glycation end products [sRAGE] and eotaxin-3) with CRP in a population of hypertensive patients at high cardiovascular risk. Methods: Plasma sRAGE, high-sensitivity CRP (hs- CRP) and eotaxin-3 were measured in 399 hypertensive patients (265 men, mean age 58 ± 8 years)with diabetes mellitus, metabolic syndrome or organ damage. Results: Plasma concentrations of sRAGE, eotaxin-3 and hs-CRP were not different between diabetic and nondiabetic subjects. Univariate analysis showed that plasma levels of sRAGE and eotaxin-3 were not associated with hs-CRP in either subgroup. Conclusion: Our study confirms the robust and widely studied role of CRP as an important marker of vascular inflammation. We also postulate the possible involvement of sRAGE and eotaxin, 2 novel biomarkers, in CVDs. On the basis of our results, we can put forward the hypotheses that hs-CRP, s-RAGE and eotaxin are reliable but unrelated cardiovascular risk markers. © 2012 Società Italiana di Nefrologia - ISSN 1121-8428.

Published
2012

28. The ABCs of post-preeclampsia outpatient nephrology care: the Le Mans strategy.

Author

Piccoli GB, De Marco O, Njandjo L, Chevé MT, and Torreggiani M

Abstract

Preeclampsia and hypertensive disorders of pregnancy complicate 3 to 5% of all pregnancies. Chronic kidney disease (CKD), at any stage, reportedly affects 3% of women in childbearing age but most of the time is underdiagnosed, especially in asymptomatic early stages. The link between preeclampsia/hypertensive disorders of pregnancy and CKD is bidirectional and women experiencing a preeclampsia/hypertensive disorder of pregnancy episode are at higher risk for developing CKD later in life, as well as metabolic and cardiovascular diseases. In turn, CKD is a risk factor for preeclampsia/hypertensive disorders of pregnancy. Thus, it is important to follow up patients after an episode of preeclampsia/hypertensive disorders of pregnancy in order to make a timely diagnosis of CKD or reduce the risk of another episode of preeclampsia/hypertensive disorder of pregnancy during a subsequent pregnancy. In Le Mans, we set up a dedicated outpatient clinic for women who experienced an episode of preeclampsia/hypertensive disorder of pregnancy. In this point of view paper, we present how we manage post-preeclampsia, in the hope that sharing this experience can promote the creation of dedicated outpatient clinics in other settings that will contribute to women's health., (© 2024. The Author(s) under exclusive licence to Italian Society of Nephrology.)

Published
2024
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29. A nurse-led multidisciplinary service for Nipple-Areola complex tattooing after breast cancer: reporting on a complex intervention with TIDieR analysis.

Author

Maselli D, Torreggiani M, and Guberti M

Abstract

Background: The Nipple-Areola Complex (NAC) tattooing can restore physical and mental integrity after breast cancer, but it is not always easily accessible for women. This paper aims to report on the development of a multidisciplinary nurse-led service for NAC tattooing for women who underwent breast cancer surgery with NAC removal to allow its thorough review and replication., Methods: The Medical Research Council's framework for developing complex healthcare interventions was followed. According to the results of a literature review, and the context analysis, an initial intervention was planned. The Template for Intervention Description and Replication checklist was chosen to ensure the quality and completeness of the intervention description., Results: The Breast Unit and the Research departments were engaged; three nurse-tattooists were selected; the informative material was created and shared with patients, families and local associations, involving them actively. Finally, the setting and the materials were defined. A monthly schedule of activities was set: patients with the indication for NAC tattooing were contacted by the nurse case manager. Each treatment involves 3-4 sessions, 30-40 days apart, in an ambulatory setting. It consists of NAC shaping and tattooing with a dermographer and sterile needles., Conclusion: Implementing freely and equally multidisciplinary nurse-led clinics might provide this treatment ensuring the patient's quality of life and nurse competence. The NAC tattooing is a complex intervention that represents the final part of the breast cancer surgical care pathway., (© 2024. The Author(s).)

Published
2024
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31. Visual supports and informative material not to forget counselling on reproductive health in dialysis: a point of view.

Author

Chimenti G, Magli A, Spanu G, Santagati G, Fois A, Njandjo L, Popa CA, Torreggiani M, and Piccoli GB

Subjects
Humans, Female, Pregnancy, Adult, Contraception methods, Kidney Failure, Chronic therapy, Patient Education as Topic, Young Adult, Fertility, Peritoneal Dialysis, Health Knowledge, Attitudes, Practice, Renal Dialysis, Reproductive Health, Counseling
Abstract

Contraception, pregnancy and fertility are seldom discussed with women receiving dialysis and the medical staff of dialysis centres. Since the majority of women on dialysis are past childbearing age, these themes are not always given proper consideration and this category of patients may be missing important information. Young women of childbearing age who are on dialysis frequently experience sexual dysfunction and hormonal disorders of the hypothalamic-pituitary-gonadal axis. In addition, dialysis often has a relevant psychological impact and affects the person's social role. Physical changes may accompany kidney failure, including the presence of a vascular or peritoneal access. The dialysis ward is not a place that facilitates privacy, and discussing contraception is not always easy, particularly in some cultural contexts, or between a male doctor and a young woman. While pregnancy and contraception are routinely addressed with women waiting for a kidney transplant, they are less frequently discussed with women on dialysis. Numerous studies have found that over half of the pregnancies in women on dialysis are unplanned. How frequently patients are seen (at each dialysis session, or during periodic visits) does not necessarily make things better, as often some issues are taken for granted or discussing them is postponed. In our centre, over 160 patients are on chronic hemodialysis (HD) and 20 are on peritoneal or home HD. Only nine women were of childbearing age in our center, all on HD. We discussed with them on counselling about pregnancy, and to ensure that all women of childbearing age would be offered counselling on contraception and pregnancy, we designed simple leaflets and an infographic, in collaboration with our nursing team and residents, as a guide and a reminder for our staff to discuss these topics with the patients., (© 2024. The Author(s) under exclusive licence to Italian Society of Nephrology.)

Published
2024
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34. Adipokines and Myokines as Markers of Malnutrition and Sarcopenia in Patients Receiving Kidney Replacement Therapy: An Observational, Cross-Sectional Study.

Author

Czaja-Stolc S, Chatrenet A, Potrykus M, Ruszkowski J, Torreggiani M, Lichodziejewska-Niemierko M, Dębska-Ślizień A, Piccoli GB, and Małgorzewicz S

Subjects
Adult, Aged, Female, Humans, Male, Middle Aged, Adiponectin blood, Cross-Sectional Studies, Hand Strength, Interleukin-6 blood, Kidney Transplantation, Myostatin blood, Nutrition Assessment, Nutritional Status, Peritoneal Dialysis, Renal Dialysis adverse effects, Renal Insufficiency, Chronic therapy, Renal Insufficiency, Chronic complications, Renal Insufficiency, Chronic blood, Renal Replacement Therapy, Adipokines blood, Biomarkers blood, Malnutrition diagnosis, Malnutrition etiology, Malnutrition blood, Myokines blood, Sarcopenia etiology, Sarcopenia blood
Abstract

Chronic kidney disease (CKD) is linked to an elevated risk of malnutrition and sarcopenia, contributing to the intricate network of CKD-related metabolic disorders. Adipokines and myokines are markers and effectors of sarcopenia and nutritional status. The aim of this study was to assess whether the adipokine-myokine signature in patients on kidney replacement therapy could help identify malnutrition and sarcopenia. The study involved three groups: 84 hemodialysis (HD) patients, 44 peritoneal dialysis (PD) patients, and 52 kidney transplant recipients (KTR). Mean age was 56.1 ± 16.3 years. Malnutrition was defined using the 7-Point Subjective Global Assessment (SGA) and the Malnutrition-Inflammation Score (MIS). Sarcopenia was diagnosed based on reduced handgrip strength (HGS) and diminished muscle mass. Concentrations of adipokines and myokines were determined using the enzyme-linked immunosorbent assay (ELISA). 32.8% of all study participants were identified as malnourished and 20.6% had sarcopenia. For malnutrition, assessed using the 7-Point SGA, in ROC analysis albumin (area under the curve (AUC) 0.67 was the best single biomarker identified. In dialysis patients, myostatin (AUC 0.79) and IL-6 (AUC 0.67) had a high discrimination value for sarcopenia, and we were able to develop a prediction model for sarcopenia, including age, albumin, adiponectin, and myostatin levels, with an AUC of 0.806 (95% CI: 0.721-0.891). Adipokines and myokines appear to be useful laboratory markers for assessing malnutrition and sarcopenia. The formula we propose could contribute to a better understanding of sarcopenia and potentially lead to more effective interventions and management strategies for dialysis patients.

Published
2024
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36. Hypertension and Proteinuria in a Pregnancy: A Quiz.

Author

Torreggiani M, Stancanelli MR, Njandjo L, Fois A, and Piccoli GB

Subjects
Female, Humans, Pregnancy, Hypertension complications, Hypertension etiology, Hypertension diagnosis, Pregnancy Complications diagnosis, Adolescent, Proteinuria etiology, Proteinuria diagnosis
Published
2024
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38. Any reduction in maternal kidney mass makes a difference during pregnancy in gestational and fetal outcome.

Author

Piccoli GB, Attini R, Torreggiani M, Chatrenet A, Manzione AM, Masturzo B, Casula V, Longhitano E, Dalmasso E, Biancone L, Pani A, and Cabiddu G

Subjects
Pregnancy, Infant, Newborn, Humans, Female, Pregnancy Outcome epidemiology, Kidney, Solitary Kidney complications, Renal Insufficiency, Chronic diagnosis, Renal Insufficiency, Chronic epidemiology, Renal Insufficiency, Chronic complications, Pyelonephritis
Abstract

Little is known about the effect tubulointerstitial nephropathies have in modulating maternal-fetal outcomes in pregnancy. Therefore, we analyzed the main outcomes of pregnancy in these women to gain a better understanding of the role of a reduction in maternal kidney mass. From the Torino Cagliari Observational Study (TOCOS) cohort, we selected 529 patients with a diagnosis of tubulointerstitial disease and focused on 421 patients with chronic kidney disease (CKD) stage 1, without hypertension but with proteinuria less than 0.5 g/day at referral. From a cohort of 2969 singleton deliveries from low-risk pregnancies followed in the same settings we selected a propensity score matched control cohort of 842 pregnancies match 2:1 for age, parity, body mass index, ethnicity, and origin. Time to delivery was significantly shorter in the study cohort 38.0 (Quartile 1-Quartile 3: 37.0-39.0) versus 39.0 (Q1-Q3 38.0-40.0) weeks, with respect to controls. Incidence of delivery of less than 37 gestational weeks significantly increased from controls (7.4%) to women with previous acute pyelonephritis (10.8%), other tubulointerstitial diseases (9.7%) and was the highest in patients with a single kidney (31.1%). Similarly, neonatal birthweight significantly and progressively decreased from controls (3260 g [Q1-Q3: 2980-3530]), previous acute pyelonephritis (3090 g [Q1-Q3: 2868-3405], other tubulointerstitial diseases (3110 g [Q1-Q3: 2840-3417]), and to solitary kidney (2910 g [Q1-Q3: 2480-3240]). Risk of developing preeclampsia was significantly higher in the CKD cohort (3.6% vs 1.7% in low-risk controls). Thus, even a small reduction in functional kidney mass, such as a pyelonephritic scar, is associated with a shorter duration of pregnancy and an increased risk of preterm delivery. The risk is proportional to the extent of parenchymal reduction and is highest in cases with a solitary kidney., (Copyright © 2024 International Society of Nephrology. Published by Elsevier Inc. All rights reserved.)

Published
2024
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39. Tattooing to reconstruct Nipple-Areola Complex after oncological breast surgery: a scoping review.

Author

Maselli D, Torreggiani M, Livieri T, Farioli G, Lucchi S, and Guberti M

Subjects
Humans, Female, Tattooing methods, Breast Neoplasms surgery, Nipples surgery, Mammaplasty methods
Abstract

Purpose: The dermopigmentation of the Nipple-Areola Complex (NAC) is a safe non-surgical reconstruction technique that can restore psychophysical integrity, representing the final step after oncological surgery. This scoping review aims to identify and synthesize the literature focused on medical tattooing for NAC reconstruction in women who underwent breast reconstruction after cancer surgery. Competence and training, outcomes and organizational aspects were assessed as specific outcomes., Methods: The Joanna Briggs Institute (JBI) methodology for scoping reviews was followed. MEDLINE, Embase, Cochrane Library, Clinical Key, Scopus and Cinahl databases were consulted. After title (N = 54) and abstract (N = 39) screening and full-text review (N = 18), articles that met eligibility criteria were analyzed, critically apprised and narratively synthesized., Results: 13 articles were analysed, with full texts (N = 11) and only abstract (N = 2). The overall quality of the literature (N observational studies = 11; N pilot experimental studies = 2) is weak. Nurses were the professionals mostly involved (N = 6), then medical staff (N = 4) and tattoo artists (N = 2). The professional training is poorly described in 6 papers. The most frequently assessed outcome was the satisfaction rate (N = 8). One study explored aspects of quality of life with a validated questionnaire. The management of these services resulted variable. Nurse-led services were implemented in 2 studies., Conclusion: Despite methodological weaknesses, NAC tattooing research is relevant because it helps women redefine their identity after demolitive cancer treatments. Further research on processes and outcomes is needed., (© 2024. The Author(s).)

Published
2024
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40. Models of Care in Providing Comprehensive Healthcare on Cancer Survivors: A Scoping Review with a TIDieR Checklist Analysis.

Author

Torreggiani M, Maselli D, Costi S, and Guberti M

Subjects
Humans, Comprehensive Health Care, Checklist, Neoplasms therapy, Patient Care Planning, Cancer Survivors statistics & numerical data
Abstract

Background: The study's aim is to identify the models of care used to provide survivorship care plans (SCPs) to cancer survivors in healthcare services, describing what kind of professionals are involved, in which settings and timings, and their feasibility., Methods: The Joanna Briggs Institute methodology for scoping reviews is followed. Studies that considered the SCPs applying different models of care, in any healthcare setting on any adult cancer survivors who completed oncological treatments, have been included. Pubmed, Embase, Cochrane Library, Scopus, and Cinahal were searched from 2013 to 2023 with these keywords: "Survivorship Care Plan", "Oncology", and "Program". The study selection process was reported with the PRISMA-ScR. A total of 325 records were identified, 42 were screened, and, ultimately, 23 articles were included., Results: The models of care include: SCP standardization in hospitals; self-support oriented; consultation-based; primary or specialist direct referral; shared care; a multimodal approach. Multidisciplinary teams were involved in the SCP models of care. The settings were private clinics or cancer centers. One-hour SCP interventions were most frequently delivered through in-person visits, by telephone, or online., Conclusions: Implementing SCPs is feasible in healthcare contexts, but with challenges, like time and resource management. Patient-centered programs promoting coordinated care are promising models of care.

Published
2024
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41. Roadmaps to green nephrology: a mediterranean point of view.

Author

Ben Hmida M, Torreggiani M, Berman-Parks N, Salomone M, and Piccoli GB

Subjects
Humans, Renal Dialysis, Environment, Nephrology
Abstract

Purpose of Review: Green nephrology is a movement whose aim is to find ways to reduce the environmental impact of kidney care. The question is of particular concern in this field since haemodialysis is one of the major contributors to waste generation, energy use and water consumption in healthcare. Although several ways for improving sustainability have been advocated, they are all context sensitive. This review aims to analyse the interventions that have been proposed to improve the ecologic sustainability and reduce the carbon footprint of nephrology care adapting to specific settings, and taking advantage of local expertise., Recent Findings: Green hospitals are becoming a reality in several high-income settings, thanks to new building guidelines, with greater awareness of climate change and users' demands. Water saving is feasible, and is increasingly done, in different ways (improving hardware, reducing and adapting dialysate flows). Recycling noncontaminated plastic waste is feasible, but is still rarely performed. However, ecological transition has been slow even in high-income countries, while in low and middle-income countries lack of resources limit the ability to cope with the planet's urgent needs. Conversely, where man-power cost is low, some time-consuming tasks, such as separation of various components for recycling may be affordable. Theoretically, implementation of all clinical tasks aiming to avoid or retard dialysis, should be a priority., Summary: There is no single roadmap for achieving green nephrology. Each setting should start from those feasible interventions most in line with its specific needs and priorities., (Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.)

Published
2024
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43. Patient-reported outcome measure to implement routine assessment of cancer survivors' unmet needs: An overview of reviews and COSMIN analysis.

Author

Contri A, Paltrinieri S, Torreggiani M, Chiara Bassi M, Mazzini E, Guberti M, Campanini I, Ghirotto L, Fugazzaro S, and Costi S

Abstract

As the number of cancer survivors (CSs) is increasing worldwide, providing services relevant to the specific, unmet needs of these individuals is crucial. There are currently various patient-reported outcome measures (PROMs) whose aim is to identify the unmet needs of CSs. Still, limited guidance supports healthcare providers in choosing the most valid and reliable PROMs for this purpose. We conducted this overview of systematic reviews (SRs) on the psychometric properties of PROMs addressing the unmet needs of adult CSs suffering from non-cutaneous cancers. We searched databases for SRs published between 2012 and January 2023. Two SRs were included, covering 14 PROMs tested on 19,151 CSs. These were assessed according to the COSMIN methodology for SRs of PROMs for the quality of their measurement properties and risk of bias, thus providing guidance in selecting PROMs that appropriately reflect the unmet needs of CSs., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 The Author(s). Published by Elsevier Ltd.. All rights reserved.)

Published
2023
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45. Analysis of the rate of force development reveals high neuromuscular fatigability in elderly patients with chronic kidney disease.

Author

Chatrenet A, Piccoli G, Audebrand JM, Torreggiani M, Barbieux J, Vaillant C, Morel B, Durand S, and Beaune B

Abstract

Background: Chronic kidney disease (CKD) induces muscle wasting and a reduction in the maximum voluntary force (MVF). Little is known about the neuromuscular fatigability in CKD patients, defined as the reduction of muscle force capacities during exercise. Neuromuscular fatigability is a crucial physical parameter of the daily living. The quantification of explosive force has been shown to be a sensitive means to assess neuromuscular fatigability. Thus, our study used explosive force estimates to assess neuromuscular fatigability in elderly CKD patients., Methods: Inclusion criteria for CKD patients were age ≥ 60 years old and glomerular filtration rate (GFR) < 45 mL/min/1.73 m 2 not on dialysis, and those for controls were GFR > 60 mL/min/1.73 m 2 , age and diabetes matched. The fatigability protocol focused on a handgrip task coupled with surface electromyography (sEMG). Scalars were extracted from the rate of force development (RFD): absolute and normalized time periods (50, 75, 100, 150 and 200 ms, RFD 50 , RFD 75 , RFD 100 , RFD 150 and RFD 200 , respectively), peak RFD (RFD peak in absolute; NRFD peak normalized), time-to-peak RFD (t-RFD peak ) and the relative force at RFD peak (MVF-RFD peak ). A statistical parametric mapping approach was performed on the force, impulse and RFD-time curves. The integrated sEMG with time at 0-30, 0-50, 0-100 and 0-200 ms time intervals relative to onset of sEMG activity was extracted and groups were compared separately for each sex., Results: The cohort of 159 individuals had a median age of 69 (9 IQR ) years and body mass index was 27.6 (6.2 IQR ) kg/m 2 . Propensity-score-matched groups balanced CKD patients and controls by gender with 66 males and 34 females. In scalar analysis, CKD patients manifested a higher decrement than controls in the early phase of contraction, regarding the NRFD peak (P = 0.009; η 2 p  = 0.034) and RFD 75 and RFD 100 (for both P < 0.001; η 2 p  = 0.068 and 0.064). The one-dimensional analysis confirmed that CKD males manifest higher and delayed neuromuscular fatigability, especially before 100 ms from onset of contraction. sEMG was lower in CKD patients than controls in the 0-100 ms (at rest: P = 0.049, Cohen's d = 0.458) and 0-200 ms (at rest: P = 0.016, Cohen's d = 0.496; during exercise: P = 0.006, Cohen's d = 0.421) time windows. Controls showed greater decrease of sEMG than CKD patients in the 0-30 ms (P = 0.020, Cohen's d = 0.533) and 0-50 ms (P = 0.010, Cohen's d = 0.640) time windows. As opposite to females, males showed almost the same differences between groups., Conclusions: Our study is the first to show that CKD patients have higher fatigability than controls, which may be associated with an impaired motor-unit recruitment, highlighting a neural drive disturbance with CKD. Further studies are needed to confirm these findings., (© 2023 The Authors. Journal of Cachexia, Sarcopenia and Muscle published by John Wiley & Sons Ltd on behalf of Society on Sarcopenia, Cachexia and Wasting Disorders.)

Published
2023
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46. Workload, Job Satisfaction and Quality of Nursing Care in Italy: A Systematic Review of Native Language Articles.

Author

Serra N, Botti S, Guillari A, Simeone S, Latina R, Iacorossi L, Torreggiani M, Guberti M, Cicolini G, Lupo R, Capuano A, Pucciarelli G, Gargiulo G, Tomietto M, and Rea T

Abstract

Nursing research is rapidly increasing, yet contributions from numerous countries that may interest the international nursing community are impeded because many research articles are published in authors' native language and not in English. The objectives of this work were to systematically review papers published in Italian related to job satisfaction and the quality of nursing care, and to discuss their findings in light of the international literature. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) method was used. The Directory of Open Access Journals (DOAJ) and Indice della Letteretura Italiana di Scienze Infermieristiche (ILISI) databases were consulted for eligible studies published from January 2015 to November 2022. Two hundred sixteen papers were identified, 11 of which were selected for review: 8 on job satisfaction, two on workload issues, and 1 on quality of nursing care. The quality of included studies was assessed through the Effective Public Health Practice Project quality assessment tool (EPHPP). The results of our review were in line with those of international literature, and they can help to fill the knowledge gap on the quality of nursing performance in Italian care settings. In addition, the proposed method can provide further elements of discussion among literature providers and reviewers.

Published
2023
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47. N-Acetylaspartate Drives Oligodendroglial Differentiation via Histone Deacetylase Activation.

Author

Dominicis A, Del Giovane A, Torreggiani M, Recchia AD, Ciccarone F, Ciriolo MR, and Ragnini-Wilson A

Subjects
Mice, Animals, Myelin Sheath metabolism, Cell Differentiation, Aspartic Acid pharmacology, Histone Deacetylases metabolism
Abstract

An unmet clinical goal in demyelinating pathologies is to restore the myelin sheath prior to neural degeneration. N-acetylaspartate (NAA) is an acetylated derivative form of aspartate, abundant in the healthy brain but severely reduced during traumatic brain injury and in patients with neurodegenerative pathologies. How extracellular NAA variations impact the remyelination process and, thereby, the ability of oligodendrocytes to remyelinate axons remains unexplored. Here, we evaluated the remyelination properties of the oligodendroglial (OL) mouse cell line Oli-neuM under different concentrations of NAA using a combination of biochemical, qPCR, immunofluorescence assays, and in vitro engagement tests, at NAA doses compatible with those observed in healthy brains and during brain injury. We observed that oligodendroglia cells respond to decreasing levels of NAA by stimulating differentiation and promoting gene expression of myelin proteins in a temporally regulated manner. Low doses of NAA potently stimulate Oli-neuM to engage with synthetic axons. Furthermore, we show a concentration-dependent expression of specific histone deacetylases essential for MBP gene expression under NAA or Clobetasol treatment. These data are consistent with the idea that oligodendrocytes respond to lowering the NAA concentration by activating the remyelination process via deacetylase activation.

Published
2023
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49. Baseline proteinuria level and adverse outcomes in pregnant women with chronic kidney disease: new evidence and a note of caution.

Author

Kervella D and Torreggiani M

Abstract

About 3% of all pregnancies occur in patients with some degree of chronic kidney disease (CKD) and, in turn, CKD is a risk factor for developing hypertensive disorders of pregnancies (HDP) and unfavorable pregnancy outcomes, at both the maternal and fetal level. CKD is often characterized by proteinuria and proteinuria is a risk factor for HDP. However, even if the positive correlation between proteinuria and unfavorable pregnancy outcomes is well acknowledged, the degree of proteinuria associated with adverse outcomes is still a matter of debate. In this issue of the Journal, Li et al. present a retrospective study that shows that >1 g of proteinuria/day is associated with worse maternal outcomes while >2 g/day with worse fetal ones. This study gives proteinuria thresholds for unfavorable outcomes in pregnant CKD patients, but it should be kept in mind that there is a linear correlation between proteinuria and worse pregnancy outcomes, thus a strict surveillance during the entire gestation should be advised independently of the proteinuria level., Competing Interests: None declared., (© The Author(s) 2023. Published by Oxford University Press on behalf of the ERA.)

Published
2023
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50. Chronic kidney disease, female infertility, and medically assisted reproduction: a best practice position statement by the Kidney and Pregnancy Group of the Italian Society of Nephrology.

Author

Attini R, Cabiddu G, Ciabatti F, Montersino B, Carosso AR, Gernone G, Gammaro L, Moroni G, Torreggiani M, Masturzo B, Santoro D, Revelli A, and Piccoli GB

Subjects
Pregnancy, Female, Humans, Pregnancy, Twin, Kidney, Infertility, Female diagnosis, Infertility, Female etiology, Infertility, Female therapy, Nephrology, Renal Insufficiency, Chronic complications, Renal Insufficiency, Chronic diagnosis, Renal Insufficiency, Chronic therapy
Abstract

Fertility is known to be impaired more frequently in patients with chronic kidney disease than in the general population. A significant proportion of chronic kidney disease patients may therefore need Medically Assisted Reproduction. The paucity of information about medically assisted reproduction for chronic kidney disease patients complicates counselling for both nephrologists and gynaecologists, specifically for patients with advanced chronic kidney disease and those on dialysis or with a transplanted kidney. It is in this context that the Project Group on Kidney and Pregnancy of the Italian Society of Nephrology has drawn up these best practice guidelines, merging a literature review, nephrology expertise and the experience of obstetricians and gynaecologists involved in medically assisted reproduction. Although all medically assisted reproduction techniques can be used for chronic kidney disease patients, caution is warranted. Inducing a twin pregnancy should be avoided; the risk of bleeding, thrombosis and infection should be considered, especially in some categories of patients. In most cases, controlled ovarian stimulation is needed to obtain an adequate number of oocytes for medically assisted reproduction. Women with chronic kidney disease are at high risk of kidney damage in case of severe ovarian hyperstimulation syndrome, and great caution should be exercised so that it is avoided. The higher risks associated with the hypertensive disorders of pregnancy, and the consequent risk of chronic kidney disease progression, should likewise be considered if egg donation is chosen. Oocyte cryopreservation should be considered for patients with autoimmune diseases who need cytotoxic treatment. In summary, medically assisted reproduction is an option for chronic kidney disease patients, but the study group strongly advises extensive personalised counselling with a multidisciplinary healthcare team and close monitoring during the chosen medically assisted reproduction procedure and throughout the subsequent pregnancy., (© 2023. The Author(s) under exclusive licence to Italian Society of Nephrology.)

Published
2023
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