10,670 results on '"Torok A"'
Search Results
2. Potential autonomous vehicle ownership growth in Hungary using the Gompertz model
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Alatawneh Anas and Torok Adam
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autonomous vehicles ,gompertz ,adoption ,gdp ,forecasting ,Machine design and drawing ,TJ227-240 ,Engineering machinery, tools, and implements ,TA213-215 - Abstract
Autonomous Vehicles (AVs) are anticipated to bring forth a multitude of advantages for upcoming mobility.These potential benefits and many others vary substantially by the market share of AVs. There are several articles that investigated AV market share with a variety of methods, however, they show a huge variation depending on the market specifications. The aim of this research is to calculate private AV adoption rates over time depending on the Hungarian automobile market characteristics. The research empirically estimates, using the Gompertz function, the projected growth rates of private autonomous passenger vehicles in Hungary using historical patterns of human-driven vehicle ownership data on the basis of projected per capita GDP.The study's findings suggest that, in an optimistic and moderate scenario, the Hungarian car market is projected to become saturated due to AVs by 2067 and 2076, respectively. However, a pessimistic estimation indicates that saturation is unlikely to occur before 2100. This study’s contribution to the literature is through a mathematical approach that predicts AVs market penetration rate and saturation year, in which the assumptions and the used parameters of the model can be modified depending on different case studies, or they can be updated due to the advancement in technology and improvement in knowledge of the studied market.
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- 2023
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3. A maternal brain hormone that builds bone
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Babey, Muriel E, Krause, William C, Chen, Kun, Herber, Candice B, Torok, Zsofia, Nikkanen, Joni, Rodriguez, Ruben, Zhang, Xiao, Castro-Navarro, Fernanda, Wang, Yuting, Wheeler, Erika E, Villeda, Saul, Leach, J Kent, Lane, Nancy E, Scheller, Erica L, Chan, Charles KF, Ambrosi, Thomas H, and Ingraham, Holly A
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Reproductive Medicine ,Biomedical and Clinical Sciences ,Nutrition ,Women's Health ,Regenerative Medicine ,Neurosciences ,Breastfeeding ,Lactation and Breast Milk ,Stem Cell Research ,Stem Cell Research - Nonembryonic - Non-Human ,1.1 Normal biological development and functioning ,Animals ,Female ,Mice ,Lactation ,Male ,Humans ,Neurons ,Arcuate Nucleus of Hypothalamus ,Osteogenesis ,Bone Remodeling ,Stem Cells ,Bone and Bones ,Calcium ,Bone Resorption ,Mice ,Inbred C57BL ,Bone Density ,Brain ,Hormones ,Mothers ,Aging ,Adolescent ,Nephroblastoma Overexpressed Protein ,General Science & Technology - Abstract
In lactating mothers, the high calcium (Ca2+) demand for milk production triggers significant bone loss1. Although oestrogen normally counteracts excessive bone resorption by promoting bone formation, this sex steroid drops precipitously during this postpartum period. Here we report that brain-derived cellular communication network factor 3 (CCN3) secreted from KISS1 neurons of the arcuate nucleus (ARCKISS1) fills this void and functions as a potent osteoanabolic factor to build bone in lactating females. We began by showing that our previously reported female-specific, dense bone phenotype2 originates from a humoral factor that promotes bone mass and acts on skeletal stem cells to increase their frequency and osteochondrogenic potential. This circulatory factor was then identified as CCN3, a brain-derived hormone from ARCKISS1 neurons that is able to stimulate mouse and human skeletal stem cell activity, increase bone remodelling and accelerate fracture repair in young and old mice of both sexes. The role of CCN3 in normal female physiology was revealed after detecting a burst of CCN3 expression in ARCKISS1 neurons coincident with lactation. After reducing CCN3 in ARCKISS1 neurons, lactating mothers lost bone and failed to sustain their progeny when challenged with a low-calcium diet. Our findings establish CCN3 as a potentially new therapeutic osteoanabolic hormone for both sexes and define a new maternal brain hormone for ensuring species survival in mammals.
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- 2024
4. Sepsis in Acute Mediastinitis – A Severe Complication after Oesophageal Perforations. A Review of the Literature
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Mureșan Mircea, Mureșan Simona, Balmoș Ioan, Sala Daniela, Suciu Bogdan, and Torok Arpad
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acute mediastinitis ,oesophageal perforation ,boerhaave syndrome ,Medical emergencies. Critical care. Intensive care. First aid ,RC86-88.9 - Abstract
Despite recent advancements in antibiotic therapy and the progress made in critical care and modern diagnostic methods, acute mediastinitis continues to be a severe condition.
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- 2019
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5. Effective Clinical Externships for International Medical Students: A Qualitative Study
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Heist, Brian S., Torok, Haruka Matsubara, and Michael Elnicki, D.
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- 2024
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6. Device infection in patients undergoing pacemaker or defibrillator surgery: risk stratification using the PADIT score
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de Heide, John, van der Graaf, Marisa, Holl, Marijn J., Hoogendijk, Mark G., Bhagwandien, Rohit E., Wijchers, Sip A., Theuns, Dominic A. M. J., Szili-Torok, Tamas, Zijlstra, Felix, Lenzen, Mattie J., and Yap, Sing-Chien
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- 2024
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7. Automatization in road transport: a review
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Torok Adam, Derenda Tadej, Zanne Marina, and Zoldy Mate
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road safety ,autonomous vehicles ,autonomous road vehicles ,public acceptance ,risk and disadvantages ,Machine design and drawing ,TJ227-240 ,Engineering machinery, tools, and implements ,TA213-215 - Abstract
In this article automatization of road transport is investigated. In the first chapter relevant international trends were identified. In this paper the research hypothesis is that in the case of automatized road vehicles there is a significant likelihood of endangering human life. Secondly, the history of road safety is shortly described, especially focusing on vehicle design and sweep of system’s theory. In the third chapter evolution of drivers’ assistance systems were elaborated, emphasizing especially autonomous vehicles. Finally, in conclusion the authors warn that new technological solutions could pose new threats.
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- 2018
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8. Timing of accreting neutron stars with future X-ray instruments: towards new constraints on dense matter equation of state
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Karas, V., Klimovicova, K., Lancova, D., Stolc, M., Svoboda, J., Torok, G., Matuszkova, M., Sramkova, E., Sprna, R., and Urbanec, M.
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Astrophysics - High Energy Astrophysical Phenomena ,Physics - Instrumentation and Detectors - Abstract
The Enhanced X-ray Timing and Polarimetry (eXTP) mission is a space mission to be launched in the late 2020s that is currently in development led by China in international collaboration with European partners. Here we provide a progress report on the Czech contribution to the eXTP science. We report on our simulation results performed in Opava (Institute of Physics of the Silesian University in Opava) and Prague (Astronomical Institute of the Czech Academy of Sciences), where the advanced timing capabilities of the satellite have been assessed for bright X-ray binaries that contain an accreting neutron star (NS) and exhibit the quasi-periodic oscillations. Measurements of X-ray variability originating in oscillations of fluid in the innermost parts of the accretion region determined by general relativity, such as the radial or Lense-Thirring precession, can serve for sensitive tests enabling us to distinguish between the signatures of different viable dense matter equations of state. We have developed formulae describing non-geodesic oscillations of accreted fluid and their simplified practical forms that allow for an expeditious application of the universal relations determining the NS properties. These relations, along with our software tools for studying the propagation of light in strong gravity and neutron star models, can be used for precise modeling of the X-ray variability while focusing on properties of the intended Large Area Detector (LAD). We update the status of our program and set up an electronic repository that will provide simulation results and gradual updates as the mission specifications progress toward their final formulation., Comment: 16 pages, 6 figures, proceedings of IBWS conference, eds. Martin Jelinek and Marianna Dafcikova, 22-26 May 2023 (Karlovy Vary, Czech Republic), ISSN: 1336-0337
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- 2024
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9. A network-level transport model of tau progression in the Alzheimer's brain
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Tora, Veronica, Torok, Justin, Bertsch, Michiel, and Raj, Ashish
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Mathematics - Analysis of PDEs ,Quantitative Biology - Neurons and Cognition ,05C90, 35A01, 35Q92, 92C50 - Abstract
One of the hallmarks of Alzheimer's disease (AD) is the accumulation and spread of toxic aggregates of tau protein. The progression of AD tau pathology is thought to be highly stereotyped, which is in part due to the fact that tau can spread between regions via the white matter tracts that connect them. Mathematically, this phenomenon has been described using models of "network diffusion", where the rate of spread of tau between brain regions is proportional to its concentration gradient and the amount of white matter between them. Although these models can robustly predict the progression of pathology in a wide variety of neurodegenerative diseases, including AD, an under explored aspect of tau spreading is that it is governed not simply by diffusion but also active transport along axonal microtubules. Spread can therefore take on a directional bias, resulting in distinct patterns of deposition, but current models struggle to capture this phenomenon. Recently, we have developed a mathematical model of the axonal transport of toxic tau proteins that takes into account the effects tau exerts on the molecular motors. Here we describe and implement a macroscopic version of this model, which we call the Network Transport Model (NTM). A key feature of this model is that, while it predicts tau dynamics at a regional level, it is parameterized in terms of only microscopic processes such as aggregation and transport rates; that is, differences in brain-wide tau progression can be explained by its microscopic properties. We provide numerical evidence that, as with the two-neuron model that the NTM extends, there are distinct and rich dynamics with respect to the overall rate of spread and the staging of pathology when we simulated the NTM on the hippocampal subnetwork. The theoretical insights provided by the NTM have broad implications for understanding AD pathophysiology more generally.
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- 2024
10. The RAPID Consortium: A Platform for Clinical and Translational Pituitary Tumor Research.
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Karsy, Michael, Kshettry, Varun, Gardner, Paul, Chicoine, Michael, Fernandez-Miranda, Juan, Evans, James, Barkhoudarian, Garni, Hardesty, Douglas, Kim, Won, Zada, Gabriel, Crocker, Tomiko, Torok, Ildiko, and Little, Andrew
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Cushings disease ,Rathkes cleft cyst ,consortium ,craniopharyngioma ,pituitary adenoma ,registry - Abstract
Objectives Pituitary tumor treatment is hampered by the relative rarity of the disease, absence of a multicenter collaborative platform, and limited translational-clinical research partnerships. Prior studies offer limited insight into the formation of a multicenter consortium. Design The authors describe the establishment of a multicenter research initiative, Registry of Adenomas of the Pituitary and Related Disorders (RAPID), to encourage quality improvement and research, promote scholarship, and apply innovative solutions in outcomes research. Methods The challenges encountered during the formation of other research registries were reviewed with those lessons applied to the development of RAPID. Setting/Participants RAPID was formed by 11 academic U.S. pituitary centers. Results A Steering Committee, bylaws, data coordination center, and leadership team have been established. Clinical modules with standardized data fields for nonfunctioning adenoma, prolactinoma, acromegaly, Cushings disease, craniopharyngioma, and Rathkes cleft cyst were created using a Health Insurance Portability and Accountability Act-compliant cloud-based platform. Currently, RAPID has received institutional review board approval at all centers, compiled retrospective data and agreements from most centers, and begun prospective data collection at one site. Existing institutional databases are being mapped to one central repository. Conclusion The RAPID consortium has laid the foundation for a multicenter collaboration to facilitate pituitary tumor and surgical research. We sought to share our experiences so that other groups also contemplating this approach may benefit. Future studies may include outcomes benchmarking, clinically annotated biobank tissue, multicenter outcomes studies, prospective intervention studies, translational research, and health economics studies focused on value-based care questions.
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- 2024
11. CORHEL-CME: An Interactive Tool For Modeling Solar Eruptions
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Linker, Jon, Torok, Tibor, Downs, Cooper, Caplan, Ronald, Titov, Viacheslav, Reyes, Andres, Lionello, Roberto, and Riley, Pete
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Astrophysics - Solar and Stellar Astrophysics ,Astrophysics - Instrumentation and Methods for Astrophysics ,Physics - Space Physics - Abstract
Coronal Mass Ejections (CMEs) are immense eruptions of plasma and magnetic fields that are propelled outward from the Sun, sometimes with velocities greater than 2000 km/s. They are responsible for some of the most severe space weather at Earth, including geomagnetic storms and solar energetic particle (SEP) events. We have developed CORHEL-CME, an interactive tool that allows non-expert users to routinely model multiple CMEs in a realistic coronal and heliospheric environment. The tool features a web-based user interface that allows the user to select a time period of interest, and employs RBSL flux ropes to create stable and unstable pre-eruptive configurations within a background global magnetic field. The properties of these configurations can first be explored in a zero-beta magnetohydrodynamic (MHD) model, followed by complete CME simulations in thermodynamic MHD, with propagation out to 1 AU. We describe design features of the interface and computations, including the innovations required to efficiently compute results on practical timescales with moderate computational resources. CORHEL-CME is now implemented at NASA's Community Coordinated Modeling Center (CCMC) using NASA Amazon Web Services (AWS). It will be available to the public by the time this paper is published., Comment: 10 pages, 6 figures, submitted to Journal of Physics Conference Series
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- 2023
12. Structuration and Genre: Revising Teaching Observations to Reflect Program Values
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Jankens, Adrienne and Torok, Joe
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In this article, we describe the process of revising our writing program's teaching observation forms and processes over the last several years, drawing from descriptions of best practices in conducting teaching observations in writing programs (Comer; Jackson). We analyze the teaching observation form as it functions in a structurational nexus to both manage participants' conversations about teaching and respond to the tensions inherent in the process (Giddens; Miller et al.). Our argument is two-fold: (1) while a responsive and reciprocal praxis for a teacher observation process may begin with good intentions surfaced through informal conversations, teaching circles, and committee meetings, it is sustainably cultivated through the intentional design of the overall process, particularly through its tangible artifacts such as email correspondence and the observation form; and (2) the teaching observation form, as an object playing a pivotal role in a series of social interactions, is a key example of a writing program genre that has the potential to both demonstrate program values and frame responsible rhetorical interactions between program personnel.
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- 2023
13. The Pathways Undergraduate Researchers Program: Fostering Career Interests, Sense of Belonging, and Student Confidence in Pursuing Science
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David Vannier, Beverly Torok-Storb, Shelley Stromholt, and Jeanne Ting Chowning
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The Pathways Undergraduate Researchers Program is a paid, nine-week summer internship at the Fred Hutchinson Cancer Center. It targets rising first-, second-, and third-year college students from backgrounds underrepresented in biomedical research. This paper describes how the internship impacted students' awareness of biomedical careers, scientific identification, and sense of belonging in research. Interns reported an increased awareness of biomedical careers and how to attain them. The experience also challenged interns' career ideas. Interns described a mix of feelings on sense of belonging. All felt welcomed and confident in their abilities. Nonetheless, some noted they were different from the other researchers. A number were motivated by being in the minority and ready to become leaders in diversifying the workforce. Data gathered during the COVID-19 pandemic shed a different light on the internship's impact. The interns reported becoming "credible resources" on public health issues for their families and communities. The program supported this by building their confidence to understand and communicate science. This undergraduate program developed out of a longer running high school internship effort and many of the strategies described herein are used in both. These findings have implications for programs for underrepresented students at the high school and college level.
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- 2023
14. Artificial intelligence in chronic kidney diseases: methodology and potential applications
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Simeri, Andrea, Pezzi, Giuseppe, Arena, Roberta, Papalia, Giuliana, Szili-Torok, Tamas, Greco, Rosita, Veltri, Pierangelo, Greco, Gianluigi, Pezzi, Vincenzo, Provenzano, Michele, and Zaza, Gianluigi
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- 2024
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15. Unsupervised restoration of a complex learned behavior after large-scale neuronal perturbation
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Wang, Bo, Torok, Zsofia, Duffy, Alison, Bell, David G., Wongso, Shelyn, Velho, Tarciso A. F., Fairhall, Adrienne L., and Lois, Carlos
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- 2024
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16. Translating a Culture of Quality to Clinical Research Conduct: Expanding the Clinical Development Quality Framework
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Torok, Michael, Sam, Leslie, and Hebert, Jennifer
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- 2024
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17. Genomic and morphological characterization of Knufia obscura isolated from the Mars 2020 spacecraft assembly facility
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Chander, Atul Munish, de Melo Teixeira, Marcus, Singh, Nitin K, Williams, Michael P, Parker, Ceth W, Leo, Patrick, Stajich, Jason E, Torok, Tamas, Tighe, Scott, Mason, Christopher E, and Venkateswaran, Kasthuri
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Microbiology ,Biological Sciences ,Physical Sciences ,Genetics ,Human Genome ,Phylogeny ,Mars ,Spacecraft ,Ascomycota ,Genome ,Fungal ,Genomics ,Black fungi ,Extremophile ,Trichomeriaceae ,Chaetothyriales - Abstract
Members of the family Trichomeriaceae, belonging to the Chaetothyriales order and the Ascomycota phylum, are known for their capability to inhabit hostile environments characterized by extreme temperatures, oligotrophic conditions, drought, or presence of toxic compounds. The genus Knufia encompasses many polyextremophilic species. In this report, the genomic and morphological features of the strain FJI-L2-BK-P2 presented, which was isolated from the Mars 2020 mission spacecraft assembly facility located at the Jet Propulsion Laboratory in Pasadena, California. The identification is based on sequence alignment for marker genes, multi-locus sequence analysis, and whole genome sequence phylogeny. The morphological features were studied using a diverse range of microscopic techniques (bright field, phase contrast, differential interference contrast and scanning electron microscopy). The phylogenetic marker genes of the strain FJI-L2-BK-P2 exhibited highest similarities with type strain of Knufia obscura (CBS 148926T) that was isolated from the gas tank of a car in Italy. To validate the species identity, whole genomes of both strains (FJI-L2-BK-P2 and CBS 148926T) were sequenced, annotated, and strain FJI-L2-BK-P2 was confirmed as K. obscura. The morphological analysis and description of the genomic characteristics of K. obscura FJI-L2-BK-P2 may contribute to refining the taxonomy of Knufia species. Key morphological features are reported in this K. obscura strain, resembling microsclerotia and chlamydospore-like propagules. These features known to be characteristic features in black fungi which could potentially facilitate their adaptation to harsh environments.
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- 2024
18. Placebo-resistant gut bacteria: Akkermansia muciniphila spp. and Familial Mediterranean fever disease.
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Pepoyan, Elya, Marotta, Francesco, Manvelyan, Anahit, Galstyan, Artak, Stepanyan, Lena, Grigoryan, Hasmik, Grigoryan, Liana, Mikayelyan, Mikayel, Balayan, Marine, Harutyunyan, Natalya, Mirzabekyan, Susanna, Tsaturyan, Vardan, Pepoyan, Astghik, and Torok, Tamas
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Akkermansia muciniphila ,Blautia ,Enterobacteriaceae spp. ,Faecalibacterium ,familial Mediterranean fever ,male patients ,microbiome ,placebo ,Humans ,Male ,Akkermansia ,Bacteria ,Familial Mediterranean Fever ,Gastrointestinal Microbiome ,Probiotics ,Adolescent ,Young Adult ,Adult ,Middle Aged - Abstract
INTRODUCTION: Despite numerous investigations into the impact of drugs/probiotics on the gut microbiota composition in Familial Mediterranean Fever (FMF) patients, the question as to whether there exists a significant bacterial diversity(ies) independent of the placebo effect that can be reliably considered in clinical and nutritional trials remains unresolved. METHODS: This study represents the in augural analysis of the placebos influence on the gut microbiota of both healthy individuals and FMF afflicted men, utilizing previously collected data from PhyloChip™ DNA microarray experiments. A total of 15 healthy and 15 FMF male volunteers, aged 18 to 50, participated in this partially randomized placebo trial, which is accessible through the GEO Series accession number GSE111835. RESULTS AND DISCUSSION: Key findings from current investigations include i. the anticipated divergence in gut bacteria resistance to placebo between healthy and FMF individuals, ii. the minor impact of placebo on gut bacterial diversities in healthy individuals, with Enterobacteriaceae diversities identified as placebo-resistant among healthy gut bacteria, and iii. the comprehensive influence of placebo on all bacterial phyla in the gut microbiome of FMF patients, extending to nearly all bacterial genera, except for the resilience of gut Akkermansia muciniphila spp. to placebo in FMF patients. This study underscores the susceptibility of Faecalibacterium, Blautia, and Clostridium genera to placebo. Consequently, this investigation holds significance for the proper design of placebo-controlled trials and establishes a foundation for further exploration of the gut-brain axis. Furthermore, it contributes valuable insights to discussions regarding proposals for probiotic therapies, particularly focusing on Faecalibacterium spp., Blautia spp., and Clostridium spp.
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- 2024
19. Usage of Production Functions in the Comparative Analysis of Transport Related Fuel Consumption
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Torok Adam, Torok Arpad, and Heinitz Florian
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production function ,environmental pollution ,transport emission ,fossil fuels ,Transportation and communication ,K4011-4343 - Abstract
This contribution aims to examine the relationship between the transport sector and the macroeconomy, particularly in fossil energy use, capital and labour relations. The authors have investigated the transport related fossil fuel consumption 2003 -2010 in a macroeconomic context in Hungary and Germany. The Cobb-Douglas type of production function could be justified empirically, while originating from the general CES (Constant Elasticity of Substitution) production function. Furthermore, as a policy implication, the results suggest that a solution for the for the reduction of anthropogenic CO2 driven by the combustion of fossil fuels presupposes technological innovation to reach emission reduction targets. Other measures, such as increasing the fossil fuel price by levying taxes, would consequently lead to an undesirable GDP decline.
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- 2014
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20. Identifyingy the Utility Function of Transport Services From Stated Preferences
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Andrejszki Tamas, Torok Adam, and Csete Maria
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stated preference ,utility function ,modal shift ,transport and tourism ,Transportation and communication ,K4011-4343 - Abstract
The aim of this study was to analyze the modal shift of passengers by analyzing their preferences. If the preferences of passengers are known it is possible to build up mathematically their utility function. This is the statistically correct way to simulate the modal shift of the investigated area. To capture the preferences of passengers stated preference method was used in online questionnaire. Five key factors were identified (from the point of passengers): travel cost, travel time, comfort, safety and environmental efficiency. In order to decrease the number of questions three levels were predefined these three questions made the base of the choice model. Every replier got three alternatives and they were told to choose the best for themselves. From the results of the questionnaire the formulas and the parameters of the mode choice utility function was derived. With the help of statistical sample an exponential utility function showed the best matching. For the validation process a probability model was set up to be compared to the proportions of the utilities. With this utility function it is possible to handle the changes in possible future transport services. Based on the introduced statistical approach the described method can be used to identify the effect of transport modes on regional development and tourism. The revealed utility function can help to develop proper regional development plans.
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- 2015
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21. Improved polygenic risk prediction in migraine-first patients
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Torok, Dora, Petschner, Peter, Baksa, Daniel, and Juhasz, Gabriella
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- 2024
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22. Endpoints and outcomes for localized scleroderma/morphea: a scoping literature review
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Hernandez, Alexy, Zapata Leiva, Leslie, Mutka, Maria, Torok, Kathryn S., Ledbetter, Leila, and Zigler, Christina K.
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- 2024
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23. Olfactory genes affect major depression in highly educated, emotionally stable, lean women: a bridge between animal models and precision medicine
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Eszlari, Nora, Hullam, Gabor, Gal, Zsofia, Torok, Dora, Nagy, Tamas, Millinghoffer, Andras, Baksa, Daniel, Gonda, Xenia, Antal, Peter, Bagdy, Gyorgy, and Juhasz, Gabriella
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- 2024
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24. Complementary scientific techniques for the study of Mesoamerican greenstone objects
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Knight, Willow, Gantz, Faith, Carl, Matthew, Young, Marcus L., Kovacevich, Brigitte, Crawford, Dawn, Torok, Elena, and Baas, Fran
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- 2024
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25. A simple model of edit activity in Wikipedia
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Shimada, Takashi, Ogushi, Fumiko, Torok, Janos, Kertesz, Janos, and Kaski, Kimmo
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Physics - Physics and Society ,Condensed Matter - Statistical Mechanics - Abstract
A simple dynamical model of collective edit activity of Wikipedia articles and their content evolution is introduced. Based on the recent empirical findings, each editor in the model is characterized by an ability to make content edit, i.e., improving the article by adding content and a tendency to make maintenance edit, i.e., dealing with formal aspects and maintaining the edit flow. In addition, each article is characterized by a level of maturity as compared to a potential quality needed to comprehensively cover its topic. This model is found to reproduce the basic structure of the bipartite network between editors and articles of Wikipedia. Furthermore, the relation between the model parameters of editors and articles and the metrics of those calculated from the emergent network turns out to be robust, i.e. depending only on the rate of the introduction of new articles to the editing activity. This results provides us a way to relate observations in the real data to the hidden characteristics of editors and articles. For the nestedness of the networks, systems with weighted parameter distribution gives better match to the empirical one. This suggests the importance of high-dimensional nature of the ability of editors and quality of articles in the real system.
- Published
- 2023
26. CD200 is overexpressed in the pancreatic tumor microenvironment and predictive of overall survival
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Wedig, Jessica, Jasani, Shrina, Mukherjee, Debasmita, Lathrop, Hannah, Matreja, Priya, Pfau, Timothy, D’Alesio, Liliana, Guenther, Abigail, Fenn, Lexie, Kaiser, Morgan, Torok, Molly A., McGue, Jake, Sizemore, Gina M., Noonan, Anne M., Dillhoff, Mary E., Blaser, Bradley W., Frankel, Timothy L., Culp, Stacey, Hart, Phil A., Cruz-Monserrate, Zobeida, and Mace, Thomas A.
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- 2024
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27. Variant STAT4 and Response to Ruxolitinib in an Autoinflammatory Syndrome
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Baghdassarian, Hratch, Blackstone, Sarah A, Clay, Owen S, Philips, Rachael, Matthiasardottir, Brynja, Nehrebecky, Michele, Hua, Vivian K, McVicar, Rachael, Liu, Yang, Tucker, Suzanne M, Randazzo, Davide, Deuitch, Natalie, Rosenzweig, Sofia, Mark, Adam, Sasik, Roman, Fisch, Kathleen M, Pimpale Chavan, Pallavi, Eren, Elif, Watts, Norman R, Ma, Chi A, Gadina, Massimo, Schwartz, Daniella M, Sanyal, Anwesha, Werner, Giffin, Murdock, David R, Horita, Nobuyuki, Chowdhury, Shimul, Dimmock, David, Jepsen, Kristen, Remmers, Elaine F, Goldbach-Mansky, Raphaela, Gahl, William A, O'Shea, John J, Milner, Joshua D, Lewis, Nathan E, Chang, Johanna, Kastner, Daniel L, Torok, Kathryn, Oda, Hirotsugu, Putnam, Christopher D, and Broderick, Lori
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Biomedical and Clinical Sciences ,Clinical Sciences ,Genetics ,Biotechnology ,Clinical Research ,Aetiology ,2.1 Biological and endogenous factors ,Inflammatory and immune system ,Janus Kinases ,Nitriles ,Pyrazoles ,Pyrimidines ,Scleroderma ,Systemic ,Autoimmune Diseases ,Mutation ,Missense ,Gain of Function Mutation ,Dermatologic Agents ,Anti-Inflammatory Agents ,Medical and Health Sciences ,General & Internal Medicine ,Biomedical and clinical sciences ,Health sciences - Abstract
BackgroundDisabling pansclerotic morphea (DPM) is a rare systemic inflammatory disorder, characterized by poor wound healing, fibrosis, cytopenias, hypogammaglobulinemia, and squamous-cell carcinoma. The cause is unknown, and mortality is high.MethodsWe evaluated four patients from three unrelated families with an autosomal dominant pattern of inheritance of DPM. Genomic sequencing independently identified three heterozygous variants in a specific region of the gene that encodes signal transducer and activator of transcription 4 (STAT4). Primary skin fibroblast and cell-line assays were used to define the functional nature of the genetic defect. We also assayed gene expression using single-cell RNA sequencing of peripheral-blood mononuclear cells to identify inflammatory pathways that may be affected in DPM and that may respond to therapy.ResultsGenome sequencing revealed three novel heterozygous missense gain-of-function variants in STAT4. In vitro, primary skin fibroblasts showed enhanced interleukin-6 secretion, with impaired wound healing, contraction of the collagen matrix, and matrix secretion. Inhibition of Janus kinase (JAK)-STAT signaling with ruxolitinib led to improvement in the hyperinflammatory fibroblast phenotype in vitro and resolution of inflammatory markers and clinical symptoms in treated patients, without adverse effects. Single-cell RNA sequencing revealed expression patterns consistent with an immunodysregulatory phenotype that were appropriately modified through JAK inhibition.ConclusionsGain-of-function variants in STAT4 caused DPM in the families that we studied. The JAK inhibitor ruxolitinib attenuated the dermatologic and inflammatory phenotype in vitro and in the affected family members. (Funded by the American Academy of Allergy, Asthma, and Immunology Foundation and others.).
- Published
- 2023
28. Identification of the Neoaspergillic Acid Biosynthesis Gene Cluster by Establishing an In Vitro CRISPR-Ribonucleoprotein Genetic System in Aspergillus melleus
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Yuan, Bo, Grau, Michelle F, Murata, Ramiro Mendonça, Torok, Tamas, Venkateswaran, Kasthuri, Stajich, Jason E, and Wang, Clay CC
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Macromolecular and Materials Chemistry ,Chemical Sciences ,Physical Chemistry ,Engineering ,Chemical Engineering ,Vaccine Related ,Infectious Diseases ,Genetics ,Biotechnology ,Prevention ,Biodefense ,Materials Engineering ,Macromolecular and materials chemistry ,Physical chemistry ,Chemical engineering - Abstract
Filamentous fungi are an essential source of bioactive mycotoxins. Recent efforts have focused on developing antifungal agents that are effective against invasive yeasts, such as Candida spp. By screening fungal strains isolated from regions surrounding the Chernobyl nuclear power plant disaster for antifungal activity against Candida albicans, we found that Aspergillus melleus IMV 01140 produced compounds that inhibited the growth of the yeast. The active compound produced by A. melleus was isolated and found to be neoaspergillic acid, a compound that is closely related to aspergillic acid. While aspergillic acid and its derivatives have been characterized and were found to have antibacterial and antifungal properties, neoaspergillic acid has been much less studied. Even though neoaspergillic acid and related compounds were found to have antibacterial and antitumoral effects, further investigation into this group of compounds is limited by challenges associated with large-scale production, isolation, and purification. The production of neoaspergillic acid has been shown to require co-cultivation methods or special growth conditions. In this work, neoaspergillic acid and related compounds were found to be produced by A. melleus under laboratory growth conditions. The biosynthetic gene cluster of neoaspergillic acid was predicted using the aspergillic acid gene cluster as a model. The biosynthetic pathway for neoaspergillic acid was then confirmed by establishing an in vitro CRISPR-ribonucleoprotein system to individually delete genes within the cluster. A negative transcriptional factor, mcrA, was also eliminated to further improve the production of neoaspergillic acid and the related compounds for future studies.
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- 2023
29. Re-imagining the role of evaluation in planning for sustainability of gender equity interventions
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Sridharan, Sanjeev, primary, Torok, Debra, additional, Das, Abhijit, additional, Singh, Satish Kumar, additional, Pereira, Amanda, additional, and Nakaima, April, additional
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- 2024
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30. Examination of Domestic Transport Parameters in the Light of Road Freight Transport
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Boldizsar, Adrienn, Torok, Adam, Szander, Norina, Clausen, Uwe, Series Editor, Hompel, Michael ten, Series Editor, de Souza, Robert, Series Editor, Tamás, Péter, editor, Bányai, Tamás, editor, Telek, Péter, editor, and Cservenák, Ákos, editor
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- 2024
- Full Text
- View/download PDF
31. The Effect of a Face Wall on a Cellular Structure During Bending
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Monkova, Katarina, Monka, Peter Pavol, Koroľ, Martin, Torok, Jozef, Beňo, Pavel, Chlamtac, Imrich, Series Editor, Cagáňová, Dagmar, editor, Cehlár, Michal, editor, and Horňáková, Natália, editor
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- 2024
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32. Fetal Pulmonary Venous Anomalies
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Taqatqa, Anas, Alsaied, Tarek, Miller, Stephen G., Torok, Rachel, Anderson, Robert H., editor, Backer, Carl L., editor, Berger, Stuart, editor, Blom, Nico A., editor, Holzer, Ralf J., editor, Robinson, Joshua D., editor, and Abdulla, Ra-id, Editor-in-Chief
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- 2024
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33. Connectome-based biophysics models of Alzheimer’s disease diagnosis and prognosis
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Torok, Justin, Anand, Chaitali, Verma, Parul, and Raj, Ashish
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Biochemistry and Cell Biology ,Biological Sciences ,Aging ,Brain Disorders ,Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) ,Alzheimer's Disease ,Neurosciences ,Dementia ,Neurodegenerative ,Acquired Cognitive Impairment ,Neurological ,Humans ,Alzheimer Disease ,Connectome ,tau Proteins ,Amyloid beta-Peptides ,Prognosis ,Clinical Sciences ,General Clinical Medicine ,Biochemistry and cell biology ,Clinical sciences - Abstract
With the increasing prevalence of Alzheimer's disease (AD) among aging populations and the limited therapeutic options available to slow or reverse its progression, the need has never been greater for improved diagnostic tools for identifying patients in the preclinical and prodomal phases of AD. Biophysics models of the connectome-based spread of amyloid-beta (Aβ) and microtubule-associated protein tau (τ) have enjoyed recent success as tools for predicting the time course of AD-related pathological changes. However, given the complex etiology of AD, which involves not only connectome-based spread of protein pathology but also the interactions of many molecular and cellular players over multiple spatiotemporal scales, more robust, complete biophysics models are needed to better understand AD pathophysiology and ultimately provide accurate patient-specific diagnoses and prognoses. Here we discuss several areas of active research in AD whose insights can be used to enhance the mathematical modeling of AD pathology as well as recent attempts at developing improved connectome-based biophysics models. These efforts toward a comprehensive yet parsimonious mathematical description of AD hold great promise for improving both the diagnosis of patients at risk for AD and our mechanistic understanding of how AD progresses.
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- 2023
34. Metagenomic Methods for Addressing NASA's Planetary Protection Policy Requirements on Future Missions: A Workshop Report.
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Green, Stefan J, Torok, Tamas, Allen, Jonathan E, Eloe-Fadrosh, Emiley, Jackson, Scott A, Jiang, Sunny C, Levine, Stuart S, Levy, Shawn, Schriml, Lynn M, Thomas, W Kelley, Wood, Jason M, and Tighe, Scott W
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Contamination ,DNA ,Metagenomics ,Planetary protection ,Spacecraft Assembly Facility ,Astronomical and Space Sciences ,Geochemistry ,Geology ,Astronomy & Astrophysics - Abstract
Molecular biology methods and technologies have advanced substantially over the past decade. These new molecular methods should be incorporated among the standard tools of planetary protection (PP) and could be validated for incorporation by 2026. To address the feasibility of applying modern molecular techniques to such an application, NASA conducted a technology workshop with private industry partners, academics, and government agency stakeholders, along with NASA staff and contractors. The technical discussions and presentations of the Multi-Mission Metagenomics Technology Development Workshop focused on modernizing and supplementing the current PP assays. The goals of the workshop were to assess the state of metagenomics and other advanced molecular techniques in the context of providing a validated framework to supplement the bacterial endospore-based NASA Standard Assay and to identify knowledge and technology gaps. In particular, workshop participants were tasked with discussing metagenomics as a stand-alone technology to provide rapid and comprehensive analysis of total nucleic acids and viable microorganisms on spacecraft surfaces, thereby allowing for the development of tailored and cost-effective microbial reduction plans for each hardware item on a spacecraft. Workshop participants recommended metagenomics approaches as the only data source that can adequately feed into quantitative microbial risk assessment models for evaluating the risk of forward (exploring extraterrestrial planet) and back (Earth harmful biological) contamination. Participants were unanimous that a metagenomics workflow, in tandem with rapid targeted quantitative (digital) PCR, represents a revolutionary advance over existing methods for the assessment of microbial bioburden on spacecraft surfaces. The workshop highlighted low biomass sampling, reagent contamination, and inconsistent bioinformatics data analysis as key areas for technology development. Finally, it was concluded that implementing metagenomics as an additional workflow for addressing concerns of NASA's robotic mission will represent a dramatic improvement in technology advancement for PP and will benefit future missions where mission success is affected by backward and forward contamination.
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- 2023
35. k-MS: A novel clustering algorithm based on morphological reconstruction
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Rodrigues, É. O., Torok, L., Liatsis, P., Viterbo, J., and Conci, A.
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Computer Science - Machine Learning ,Computer Science - Artificial Intelligence ,Computer Science - Graphics - Abstract
This work proposes a clusterization algorithm called k-Morphological Sets (k-MS), based on morphological reconstruction and heuristics. k-MS is faster than the CPU-parallel k-Means in worst case scenarios and produces enhanced visualizations of the dataset as well as very distinct clusterizations. It is also faster than similar clusterization methods that are sensitive to density and shapes such as Mitosis and TRICLUST. In addition, k-MS is deterministic and has an intrinsic sense of maximal clusters that can be created for a given input sample and input parameters, differing from k-Means and other clusterization algorithms. In other words, given a constant k, a structuring element and a dataset, k-MS produces k or less clusters without using random/ pseudo-random functions. Finally, the proposed algorithm also provides a straightforward means for removing noise from images or datasets in general.
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- 2022
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36. T-cell depleted allogeneic hematopoietic stem cell transplant for the treatment of Fanconi anemia and MDS/AML
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Satty, Alexandra M., Klein, Elizabeth, Mauguen, Audrey, Kunvarjee, Binni, Boelens, Jaap Jan, Cancio, Maria, Curran, Kevin J., Kernan, Nancy A., Prockop, Susan E., Scaradavou, Andromachi, Spitzer, Barbara, Tamari, Roni, Ruggiero, Julianne, Torok-Castanza, Joanne, Mehta, Parinda A., O’Reilly, Richard J., and Boulad, Farid
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- 2024
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37. Co-design and Development of Implementation Strategies: Enhancing the PAX Good Behaviour Game in Australian Schools
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Baffsky, Rachel, Ivers, Rebecca, Cullen, Patricia, McGillivray, Lauren, Werner-Seidler, Aliza, Calear, Alison L., Batterham, Philip J., Toumbourou, John W., Stokes, Rhoni, Kotselas, Pauline, Prendergast, Traci, and Torok, Michelle
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- 2023
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38. The performance of dipole charge density mapping integrated with robotic magnetic navigation in the treatment of atrial tachycardias
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Gagyi, Rita B., Yap, Sing-Chien, Noten, Anna M. E., Wijchers, Sip, and Szili-Torok, Tamas
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- 2023
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39. The LBNL Superfacility Project Report
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Bard, Deborah, Snavely, Cory, Gerhardt, Lisa, Lee, Jason, Totzke, Becci, Antypas, Katie, Arndt, William, Blaschke, Johannes, Byna, Suren, Cheema, Ravi, Cholia, Shreyas, Day, Mark, Enders, Bjoern, Gaur, Aditi, Greiner, Annette, Groves, Taylor, Kiran, Mariam, Koziol, Quincey, Lehman, Tom, Rowland, Kelly, Samuel, Chris, Selvarajan, Ashwin, Sim, Alex, Skinner, David, Stephey, Laurie, Thomas, Rollin, and Torok, Gabor
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Computer Science - Distributed, Parallel, and Cluster Computing - Abstract
The Superfacility model is designed to leverage HPC for experimental science. It is more than simply a model of connected experiment, network, and HPC facilities; it encompasses the full ecosystem of infrastructure, software, tools, and expertise needed to make connected facilities easy to use. The three-year Lawrence Berkeley National Laboratory (LBNL) Superfacility project was initiated in 2019 to coordinate work being performed at LBNL to support this model, and to provide a coherent and comprehensive set of science requirements to drive existing and new work. A key component of the project was the in-depth engagements with eight science teams that represent challenging use cases across the DOE Office of Science. By the close of the project, we met our project goal by enabling our science application engagements to demonstrate automated pipelines that analyze data from remote facilities at large scale, without routine human intervention. In several cases, we have gone beyond demonstrations and now provide production-level services. To achieve this goal, the Superfacility team developed tools, infrastructure, and policies for near-real-time computing support, dynamic high-performance networking, data management and movement tools, API-driven automation, HPC-scale notebooks via Jupyter, authentication using Federated Identity and container-based edge services supported. The lessons we learned during this project provide a valuable model for future large, complex, cross-disciplinary collaborations. There is a pressing need for a coherent computing infrastructure across national facilities, and LBNL's Superfacility project is a unique model for success in tackling the challenges that will be faced in hardware, software, policies, and services across multiple science domains., Comment: 85 pages, 23 figures
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- 2022
40. Host genetics and gut microbiota composition: Baseline gut microbiota composition as a possible prognostic factor for the severity of COVID-19 in patients with familial Mediterranean fever disease
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Tsaturyan, Vardan, Manvelyan, Anahit, Balayan, Marine, Harutyunyan, Natalya, Pepoyan, Elya, Torok, Tamas, Chikindas, Michael, and Pepoyan, Astghik
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Microbiology ,Biological Sciences ,Biomedical and Clinical Sciences ,Infectious Diseases ,Prevention ,Clinical Research ,Emerging Infectious Diseases ,Aetiology ,2.1 Biological and endogenous factors ,2.2 Factors relating to the physical environment ,Infection ,COVID-19 ,disease severity analysis ,familial Mediterranean fever disease ,gender ,gut microbiota ,Environmental Science and Management ,Soil Sciences ,Medical microbiology - Abstract
BackgroundIt is known that the gut microbiome of a healthy person affects the process of COVID-19 after getting infected with SARS-CoV-2 virus. It is also believed that colchicine can alleviate the severity of COVID-19.ObjectiveCurrent investigations aimed to evaluate the associations between the baseline gut microbiota composition of healthy and Familial Mediterranean fever (FMF) - carrier Armenian men populations, and the severity of the COVID-19 disease after their infection with the SARS-CoV-2. The study has a purpose of answering three core questions: i. Do the characteristics of gut microbiome of Armenians affect the course of COVID-19 severity? ii. How does the COVID-19 disease course on go for FMF patients who have been taking colchicine as a medication over the years after getting infected with SARS-CoV-2? iii. Is there an initial gut micribiota structure pattern for non-FMF and FMF patients in the cases when COVID-19 appears in mild form?MethodsThe gut microbiota composition in non-FMF and FMF patients before the first infection (mild and moderate course of COVID-19) was considered. COVID-19 was diagnosed by SARS-CoV-2 nucleic acid RT-PCR in nasopharyngeal swab and/or sputum.ResultsThe number of patients with male FMF with mild COVID-19 was approximately two times higher than that of non-FMF male subjects with COVID-19. In addition, an association of COVID-19 disease severity with the baseline gut Prevotella, Clostridium hiranonis, Eubacterium biforme, Veillonellaceae, Coprococcus, and Blautia diversities in the non-FMF and FMF populations were revealed by us, which can be used as risk/prognostic factor for the severity of COVID-19.
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- 2023
41. Description and Genome Characterization of Three Novel Fungal Strains Isolated from Mars 2020 Mission-Associated Spacecraft Assembly Facility Surfaces—Recommendations for Two New Genera and One Species
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Chander, Atul Munish, de Melo Teixeira, Marcus, Singh, Nitin K, Williams, Michael P, Simpson, Anna C, Damle, Namita, Parker, Ceth W, Stajich, Jason E, Mason, Christopher E, Torok, Tamas, and Venkateswaran, Kasthuri
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Microbiology ,Biological Sciences ,Genetics ,Biotechnology ,Aaosphaeria pasadenensis ,Floridaphiala radiotolerans ,fungi ,genomics ,Mars 2020 mission ,Pasadenomyces melaninifex ,phylogenetic analysis - Abstract
National Aeronautics and Space Administration’s (NASA) spacecraft assembly facilities are monitored for the presence of any bacteria or fungi that might conceivably survive a transfer to an extraterrestrial environment. Fungi present a broad and diverse range of phenotypic and functional traits to adapt to extreme conditions, hence the detection of fungi and subsequent eradication of them are needed to prevent forward contamination for future NASA missions. During the construction and assembly for the Mars 2020 mission, three fungal strains with unique morphological and phylogenetic properties were isolated from spacecraft assembly facilities. The reconstruction of phylogenetic trees based on several gene loci (ITS, LSU, SSU, RPB, TUB, TEF1) using multi-locus sequence typing (MLST) and whole genome sequencing (WGS) analyses supported the hypothesis that these were novel species. Here we report the genus or species-level classification of these three novel strains via a polyphasic approach using phylogenetic analysis, colony and cell morphology, and comparative analysis of WGS. The strain FJI-L9-BK-P1 isolated from the Jet Propulsion Laboratory Spacecraft Assembly Facility (JPL-SAF) exhibited a putative phylogenetic relationship with the strain Aaosphaeria arxii CBS175.79 but showed distinct morphology and microscopic features. Another JPL-SAF strain, FJII-L3-CM-DR1, was phylogenetically distinct from members of the family Trichomeriaceae and exhibited morphologically different features from the genera Lithohypha and Strelitziana. The strain FKI-L1-BK-DR1 isolated from the Kennedy Space Center facility was identified as a member of Dothideomycetes incertae sedis and is closely related to the family Kirschsteiniotheliaceae according to a phylogenetic analysis. The polyphasic taxonomic approach supported the recommendation for establishing two novel genera and one novel species. The names Aaosphaeria pasadenensis (FJI-L9-BK-P1 = NRRL 64424 = DSM 114621), Pasadenomyces melaninifex (FJII-L3-CM-DR1 = NRRL 64433 = DSM 114623), and Floridaphiala radiotolerans (FKI-L1-BK-DR1 = NRRL 64434 = DSM 114624) are proposed as type species. Furthermore, resistance to ultraviolet-C and presence of specific biosynthetic gene cluster(s) coding for metabolically active compounds are unique to these strains.
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- 2023
42. Interleukin (IL)-1/IL-6-Inhibitor–Associated Drug Reaction With Eosinophilia and Systemic Symptoms (DReSS) in Systemic Inflammatory Illnesses
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Aamir, R., Abulaban, K., Adams, A., Lapsia, C. Aguiar, Akinsete, A., Akoghlanian, S., Al Manaa, M., AlBijadi, A., Allenspach, E., Almutairi, A., Alperin, R., Amarilyo, G., Ambler, W., Amoruso, M., Angeles-Han, S., Ardoin, S., Armendariz, S., Asfaw, L., Aviran Dagan, N., Bacha, C., Balboni, I., Balevic, S., Ballinger, S., Baluta, S., Barillas-Arias, L., Basiaga, M., Baszis, K., Baxter, S., Becker, M., Begezda, A., Behrens, E., Beil, E., Benseler, S., Bermudez-Santiago, L., Bernal, W., Bigley, T., Bingham, C., Binstadt, B., Black, C., Blackmon, B., Blakley, M., Bohnsack, J., Boneparth, A., Bradfield, H., Bridges, J., Brooks, E., Brothers, M., Brunner, H., Buckley, L., Buckley, M., Bukulmez, H., Bullock, D., Canna, S., Cannon, L., Canny, S., Cartwright, V., Cassidy, E., Castro, D., Chalom, E., Chang, J., Chang, M., Chang-Hoftman, A., Chen, A., Chiraseveenuprapund, P., Ciaglia, K., Co, D., Cohen, E., Collinge, J., Conlon, H., Connor, R., Cook, K., Cooper, A., Cooper, J., Corbin, K., Correll, C., Cron, R., Curry, M., Dalrymple, A., Datyner, E., Davis, T., De Ranieri, D., Dean, J., DeCoste, C., Dedeoglu, F., DeGuzman, M., Delnay, N., DeSantis, E., Devine, R., Dhalla, M., Dhanrajani, A., Dissanayake, D., Dizon, B., Drapeau, N., Drew, J., Driest, K., Du, Q., Duncan, E., Dunnock, K., Durkee, D., Dvergsten, J., Eberhard, A., Ede, K., Edelheit, B., Edens, C., El Tal, T., Elder, M., Elzaki, Y., Fadrhonc, S., Failing, C., Fair, D., Favier, L., Feldman, B., Fennell, J., Ferguson, P., Ferguson, I., Figueroa, C., Flanagan, E., Fogel, L., Fox, E., Fox, M., Franklin, L., Fuhlbrigge, R., Fuller, J., Furey, M., Futch-West, T., Gagne, S., Gennaro, V., Gerstbacher, D., Gilbert, M., Gironella, A., Glaser, D., Goh, I., Goldsmith, D., Gorry, S., Goswami, N., Gottlieb, B., Graham, T., Grevich, S., Griffin, T., Grim, A., Grom, A., Guevara, M., Hahn, T., Halyabar, O., Hamda Natur, M., Hammelev, E., Hammond, T., Harel, L., Harris, J., Harry, O., Hausmann, J., Hay, A., Hays, K., Hayward, K., Henderson, L., Henrickson, M., Hersh, A., Hickey, K., Hiraki, L., Hiskey, M., Hobday, P., Hoffart, C., Holland, M., Hollander, M., Hong, S., Horton, D., Horwitz, M., Hsu, J., Huber, A., Huberts, A., Huggins, J., Huie, L., Hui-Yuen, J., Ibarra, M., Imlay, A., Imundo, L., Inman, C., Jackson, A., James, K., Janow, G., Jared, S., Jiang, Y., Johnson, L., Johnson, N., Jones, J., Kafisheh, D., Kahn, P., Kaidar, K., Kasinathan, S., Kaur, R., Kessler, E., Kienzle, B., Kim, S., Kimura, Y., Kingsbury, D., Kitcharoensakkul, M., Klausmeier, T., Klein, K., Klein-Gitelman, M., Knight, A., Kovalick, L., Kramer, S., Kremer, C., Kudas, O., LaFlam, T., Lang, B., Lapidus, S., Lapin, B., Lasky, A., Lawler, C., Lawson, E., Laxer, R., Lee, P., Lee, T., Lee, A., Leisinger, E., Lentini, L., Lerman, M., Levinsky, Y., Levy, D., Li, S., Lieberman, S., Lim, L., Limenis, E., Lin, C., Ling, N., Lionetti, G., Livny, R., Lloyd, M., Lo, M., Long, A., Lopez-Peña, M., Lovell, D., Luca, N., Lvovich, S., Lytch, A., Ma, M., Machado, A., MacMahon, J., Madison, J., Mannion, M., Manos, C., Mansfield, L., Marston, B., Mason, T., Matchett, D., McAllister, L., McBrearty, K., McColl, J., McCurdy, D., McDaniels, K., McDonald, J., Meidan, E., Mellins, E., Mian, Z., Miettunen, P., Miller, M., Milojevic, D., Mitacek, R., Modica, R., Mohan, S., Moore, T., Moore, K., Moorthy, L., Moreno, J., Morgan, E., Moyer, A., Murante, B., Murphy, A., Muscal, E., Mwizerwa, O., Najafi, A., Nanda, K., Nasah, N., Nassi, L., Nativ, S., Natter, M., Nearanz, K., Neely, J., Newhall, L., Nguyen, A., Nigrovic, P., Nocton, J., Nolan, B., Nowicki, K., Oakes, R., Oberle, E., Ogbonnaya-Whittesley, S., Ogbu, E., Oliver, M., Olveda, R., Onel, K., Orandi, A., Padam, J., Paller, A., Pan, N., Pandya, J., Panupattanapong, S., Toledano, A. Pappo, Parsons, A., Patel, J., Patel, P., Patrick, A., Patrizi, S., Paul, S., Perfetto, J., Perron, M., Peskin, M., Ponder, L., Pooni, R., Prahalad, S., Puplava, B., Quinlan-Waters, M., Rabinovich, C., Rafko, J., Rahimi, H., Rampone, K., Ramsey, S., Randell, R., Ray, L., Reed, A., Reid, H., Reiff, D., Richins, S., Riebschleger, M., Rife, E., Riordan, M., Riskalla, M., Robinson, A., Robinson, L., Rodgers, L., Rodriquez, M., Rogers, D., Ronis, T., Rosado, A., Rosenkranz, M., Rosenwasser, N., Rothermel, H., Rothman, D., Rothschild, E., Roth-Wojcicki, E., Rouster-Stevens, K., Rubinstein, T., Rupp, J., Ruth, N., Sabbagh, S., Sadun, R., Santiago, L., Saper, V., Sarkissian, A., Scalzi, L., Schahn, J., Schikler, K., Schlefman, A., Schmeling, H., Schmitt, E., Schneider, R., Schulert, G., Schultz, K., Schutt, C., Seper, C., Sheets, R., Shehab, A., Shenoi, S., Sherman, M., Shirley, J., Shishov, M., Siegel, D., Singer, N., Sivaraman, V., Sloan, E., Smith, C., Smith, J., Smitherman, E., Soep, J., Son, Mary B., Sosna, D., Spencer, C., Spiegel, L., Spitznagle, J., Srinivasalu, H., Stapp, H., Steigerwald, K., Stephens, A., Sterba Rakovchik, Y., Stern, S., Stevens, B., Stevenson, R., Stewart, K., Stewart, W., Stingl, C., Stoll, M., Stringer, E., Sule, S., Sullivan, J., Sundel, R., Sutter, M., Swaffar, C., Swayne, N., Syed, R., Symington, T., Syverson, G., Szymanski, A., Taber, S., Tal, R., Tambralli, A., Taneja, A., Tanner, T., Tarvin, S., Tate, L., Taxter, A., Taylor, J., Tesher, M., Thakurdeen, T., Theisen, A., Thomas, B., Thomas, L., Thomas, N., Ting, T., Todd, C., Toib, D., Torok, K., Tory, H., Toth, M., Tse, S., Tsin, C., Twachtman-Bassett, J., Twilt, M., Valcarcel, T., Valdovinos, R., Vallee, A., Van Mater, H., Vandenbergen, S., Vannoy, L., Varghese, C., Vasquez, N., Vega-Fernandez, P., Velez, J., Verbsky, J., Verstegen, R., von Scheven, E., Vora, S., Wagner-Weiner, L., Wahezi, D., Waite, H., Walker, B., Walters, H., Waterfield, M., Waters, A., Weiser, P., Weiss, P., Weiss, J., Wershba, E., Westheuser, V., White, A., Widrick, K., Williams, C., Wong, S., Woolnough, L., Wright, T., Wu, E., Yalcindag, A., Yasin, S., Yeung, R., Yomogida, K., Zeft, A., Zhang, Y., Zhao, Y., Zhu, A., Saper, Vivian E., Tian, Lu, Verstegen, Ruud H.J., Conrad, Carol K., Cidon, Michal, Hopper, Rachel K., Kuo, Christin S., Osoegawa, Kazutoyo, Baszis, Kevin, Bingham, Catherine A., Ferguson, Ian, Hahn, Timothy, Horne, Annacarin, Isupova, Eugenia A., Jones, Jordan T., Kasapcopur, Özgür, Klein-Gitelman, Marisa S., Kostik, Mikhail M., Ozen, Seza, Phadke, Omkar, Prahalad, Sampath, Randell, Rachel L., Sener, Seher, Stingl, Cory, Abdul-Aziz, Rabheh, Akoghlanian, Shoghik, Al Julandani, Dalila, Alvarez, Marcela B., Bader-Meunier, Brigitte, Balay-Dustrude, Erin E., Balboni, Imelda, Baxter, Sarah K., Berard, Roberta A., Bhattad, Sagar, Bolaria, Roxana, Boneparth, Alexis, Cassidy, Elaine A., Co, Dominic O., Collins, Kathleen P., Dancey, Paul, Dickinson, Aileen M., Edelheit, Barbara S., Espada, Graciela, Flanagan, Elaine R., Imundo, Lisa F., Jindal, Ankur K., Kim, Hyoun-Ah, Klaus, Günter, Lake, Carol, Lapin, W. Blaine, Lawson, Erica F., Marmor, Itay, Mombourquette, Joy, Ogunjimi, Benson, Olveda, Rebecca, Ombrello, Michael J., Onel, Karen, Poholek, Catherine, Ramanan, Athimalaipet V., Ravelli, Angelo, Reinhardt, Adam, Robinson, Amanda D., Rouster-Stevens, Kelly, Saad, Nadine, Schneider, Rayfel, Selmanovic, Velma, Sefic Pasic, Irmina, Shenoi, Susan, Shilo, Natalie R., Soep, Jennifer B., Sura, Angeli, Taber, Sarah F., Tesher, Melissa, Tibaldi, Jessica, Torok, Kathryn S., Tsin, Cathy Mei, Vasquez-Canizares, Natalia, Villacis Nunez, Diana S., Way, Emily E., Whitehead, Benjamin, Zemel, Lawrence S., Sharma, Surbhi, Fernández-Viña, Marcelo A., and Mellins, Elizabeth D.
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- 2024
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43. Strategies for Enhancing the Implementation of Universal Mental Health Prevention Programs in Schools: A Systematic Review
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Baffsky, Rachel, Ivers, Rebecca, Cullen, Patricia, Wang, Jessica, McGillivray, Lauren, and Torok, Michelle
- Abstract
A number of school-based mental health prevention programs have been found to be effective in research trials, but little is known about how to support implementation in real-life settings. To address this translational problem, this systematic review aims to identify effective strategies for enhancing the implementation of mental health prevention programs for children in schools. Four electronic databases were searched for empirical, peer-reviewed articles in English from January 2000 to October 2021 reporting the effects of implementation strategies for school-based universal mental health programs. Twenty-one articles were included in the narrative synthesis and assessed for quality using the Mixed Methods Appraisal Tool. Twenty-two strategies were found to be effective at improving program fidelity or adoption. The strategies with the strongest positive evidence base were those that involved monitoring and provision of feedback, engaging principals as program leaders, improving teachers' buy-in and organising school personnel implementation meetings. We recommend school-based practitioners trial strategies with positive findings from this review as part of their continuous quality improvement. This review highlights the pressing need for large-scale, randomised controlled trials to develop and trial more robust strategies to enhance adoption, as the five implementation studies found to measure adoption used qualitative methods limited by small samples sizes and case study designs.
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- 2023
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44. Evaluating the Use of Hypothetical 'Would You Rather' Scenarios to Discuss Privacy and Security Concepts with Children.
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Elana B. Blinder, Marshini Chetty, Jessica Vitak, Zoe Torok, Salina Fessehazion, Jason Yip, Jerry Alan Fails, Elizabeth Bonsignore, and Tamara L. Clegg
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- 2024
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45. Systematic review of deep learning and machine learning for building energy
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Sina, Ardabili, Abdolalizadeh, Leila, Mako, Csaba, Torok, Bernat, and Amir, Mosavi
- Subjects
Computer Science - Machine Learning ,68T07 - Abstract
The building energy (BE) management has an essential role in urban sustainability and smart cities. Recently, the novel data science and data-driven technologies have shown significant progress in analyzing the energy consumption and energy demand data sets for a smarter energy management. The machine learning (ML) and deep learning (DL) methods and applications, in particular, have been promising for the advancement of the accurate and high-performance energy models. The present study provides a comprehensive review of ML and DL-based techniques applied for handling BE systems, and it further evaluates the performance of these techniques. Through a systematic review and a comprehensive taxonomy, the advances of ML and DL-based techniques are carefully investigated, and the promising models are introduced. According to the results obtained for energy demand forecasting, the hybrid and ensemble methods are located in high robustness range, SVM-based methods are located in good robustness limitation, ANN-based methods are located in medium robustness limitation and linear regression models are located in low robustness limitations. On the other hand, for energy consumption forecasting, DL-based, hybrid, and ensemble-based models provided the highest robustness score. ANN, SVM, and single ML models provided good and medium robustness and LR-based models provided the lower robustness score. In addition, for energy load forecasting, LR-based models provided the lower robustness score. The hybrid and ensemble-based models provided a higher robustness score. The DL-based and SVM-based techniques provided a good robustness score and ANN-based techniques provided a medium robustness score., Comment: 14 figures, 10 tables, accepted Frontiers in Energy Research: https://www.frontiersin.org/articles/10.3389/fenrg.2022.786027/abstract
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- 2022
- Full Text
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46. Observational properties of puffy disks: radiative GRMHD spectra of mildly sub-Eddington accretion
- Author
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Wielgus, Maciek, Lancova, Debora, Straub, Odele, Kluzniak, Wlodek, Narayan, Ramesh, Abarca, David, Rozanska, Agata, Vincent, Frederic, Torok, Gabriel, and Abramowicz, Marek
- Subjects
Astrophysics - High Energy Astrophysical Phenomena ,General Relativity and Quantum Cosmology - Abstract
Numerical general relativistic radiative magnetohydrodynamic simulations of accretion disks around a stellar mass black hole with a luminosity above 0.5 of the Eddington value reveal their stratified, elevated vertical structure. We refer to these thermally stable numerical solutions as puffy disks. Above a dense and geometrically thin core of dimensionless thickness $h/r \sim 0.1$, crudely resembling a classic thin accretion disk, a puffed-up, geometrically thick layer of lower density and $h/r \sim 1.0$ is formed. We discuss the observational properties of puffy disks, in particular the geometrical obscuration of the inner disk by the elevated puffy region at higher observing inclinations, and collimation of the radiation along the accretion disk spin axis, which may explain the apparent super-Eddington luminosity of some X-ray objects. We also present synthetic spectra of puffy disks, and show that they are qualitatively similar to those of a Comptonized thin disk. We demonstrate that the existing xspec spectral fitting models provide good fits to synthetic observations of puffy disks, but cannot correctly recover the input black hole spin. The puffy region remains optically thick to scattering; in its spectral properties the puffy disk roughly resembles that of a warm corona sandwiching the disk core. We suggest that puffy disks may correspond to X-ray binary systems of luminosities above 0.3 of the Eddington luminosity in the intermediate spectral states.
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- 2022
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47. QED and strong isospin corrections in the hadronic vacuum polarization contribution to the anomalous magnetic moment of the muon
- Author
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Parato, L., Borsanyi, Sz., Fodor, Z., Guenther, J. N., Hoelbling, C., Katz, S. D., Lellouch, L., Lippert, T., Miura, K., Szabo, K. K., Stokes, F., Toth, B. C., Torok, Cs., and Varnhorst, L.
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High Energy Physics - Lattice ,High Energy Physics - Phenomenology - Abstract
Recently, the Budapest-Marseille-Wuppertal collaboration achieved sub-percent precision in the evaluation of the lowest-order hadronic vacuum polarization contribution to the muon $g_\mu-2$ (arXiv:hep-lat/2002.12347v3). At this level of precision, isospin-symmetric QCD is not sufficient. In this contribution we review how QED and strong-isospin-breaking effects have been included in our work. Isospin breaking is implemented by expanding the relevant correlation functions to second order in the electric charge $e$ and to first order in $m_u-m_d$. The correction terms are then computed using isospin-symmetric configurations. The choice of this approach allows us to better distribute the available computing resources among the various contributions., Comment: talk presented at the 38th International Symposium on Lattice Field Theory, LATTICE2021 26th-30th July, 2021 Zoom/Gather@Massachusetts Institute of Technology
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- 2022
48. Challenges and complications in juvenile localized scleroderma: A practical approach
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Pain, Clare E. and Torok, Kathryn S.
- Published
- 2024
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49. A Randomized Trial of Electrographic Flow-Guided Redo Ablation for Nonparoxysmal Atrial Fibrillation (FLOW-AF)
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Reddy, Vivek Y., Langbein, Anke, Petru, Jan, Szili-Torok, Tamas, Funasako, Moritoshi, Dinshaw, Leon, Wijchers, Sip, Rillig, Andreas, Spitzer, Stefan G., Bhagwandien, Rohit, Metzner, Andreas, Kong, Melissa H., and Neuzil, Petr
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- 2024
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50. Trajectories to Suicide Following Intimate Partner Violence Victimization: Using Structural Equation Modelling to Examine Suicide and PTSD in Female Emergency Department Users
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Rasmussen, Victoria, Spangaro, Jo, Steel, Zachary, Briggs, Nancy, and Torok, Michelle
- Published
- 2023
- Full Text
- View/download PDF
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