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1. Update of the Consensus Statement of the Spanish Society of Rheumatology on the use of biological and synthetic targeted therapies in rheumatoid arthritis

Author

Álvaro-Gracia Álvaro, José María, Díaz del Campo Fontecha, Petra, Andréu Sánchez, José Luis, Balsa Criado, Alejandro, Cáliz Cáliz, Rafael, Castrejón Fernández, Isabel, Corominas, Hèctor, Gómez Puerta, José A., Manrique Arija, Sara, Mena Vázquez, Natalia, Ortiz García, Ana, Plasencia Rodríguez, Chamaida, Silva Fernández, Lucía, and Tornero Molina, Jesús

Published
2024
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2. Actualización del Documento de Consenso de la Sociedad Española de Reumatología sobre el uso de terapias biológicas y sintéticas dirigidas en la artritis reumatoide

Author

Álvaro-Gracia Álvaro, José María, Díaz del Campo Fontecha, Petra, Andréu Sánchez, José Luis, Balsa Criado, Alejandro, Cáliz Cáliz, Rafael, Castrejón Fernández, Isabel, Corominas, Hèctor, Gómez Puerta, José A., Manrique Arija, Sara, Mena Vázquez, Natalia, Ortiz García, Ana, Plasencia Rodríguez, Chamaida, Silva Fernández, Lucía, and Tornero Molina, Jesús

Published
2024
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3. Effectiveness and safety of tocilizumab in monotherapy in biologic-naïve and non-naïve patients with rheumatoid arthritis in a real-world setting

Author

Marsal Barril, Sara, Martin-Martinez, Mª Auxiliadora, Blanco-Garcia, Francisco Javier, Fernández-Nebro, Antonio, García de Vicuña, Rosario, Tornero-Molina, Jesús, Sánchez-Alonso, Fernando, Novella-Navarro, Marta, Escudero-Contreras, Alejandro, Alegre-Sancho, Juan José, Urruticoechea-Arana, Ana, Bustabad-Reyes, Maria Sagrario, Trenor-Larraz, Pilar, Pérez-Sandoval, Trinidad, Tevar-Sánchez, Maria Isabel, Sánchez-Costa, Jesús T., and Raya-Álvarez, Enrique

Published
2022
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9. Clinical outcomes of switching to adalimumab biosimilar (MSB11022) in patients with rheumatoid arthritis: RESTART Spanish Registry.

Author

García-Miguel, Javier, Yankova Komsalova, Liliya, Mata Arnaiz, Cristina, Alegre-Sancho, Juan José, González Polo, Javier, Torrente-Segarra, Vicenç, Tornero Molina, Jesús, Navarro Angeles, Vanessa Andrea, Caramés, Cristina, and Cristóbal, Ion

Subjects
BIOTHERAPY, RHEUMATOID arthritis, IMMUNE response, MEDICAL records, BIOSIMILARS
Abstract

MSB11022 is a biosimilar of adalimumab that has been shown comparable bioequivalence, safety, tolerability, and immunogenicity profiles to the reference adalimumab in healthy volunteers or in patients with psoriasis or rheumatoid arthritis (RA). This is the first study conducted under clinical practice conditions evaluating the switch from reference adalimumab to MSB11022 in patients with RA. Retrospective and multicenter study with data from the medical records of patients with RA who switched from reference adalimumab or another biosimilar to MSB11022 and maintained this treatment for at least 6 months. Information registered comes from baseline visit, the moment of the switch, and the follow-up visits. Data from 86 patients were evaluated (median age 63.5 years, 75.6% female, 44.2% had erosive RA). Only 3.5% of the patients received biologic therapy prior to adalimumab. At baseline, median DAS28-CRP was 1.77 (80.2% in remission and 96.5% with low disease activity) and median CDAI was 4.00 (44.2% in remission and 90.7% with low disease activity). After a median follow-up of 8 months, median DAS28-CRP was 1.87 (86.0% in remission and 94.2% with low disease activity) and median CDAI was 4.00 (38.5% in remission and 95.3% with low disease activity). Only three patients experienced pain, swelling, and stinging at the injection site or a locally extensive hematoma in the area of administration. Adalimumab biosimilar MSB11022 maintained the efficacy benefits provided by previous adalimumab treatments with a safety profile in line with that already described for other biosimilars. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Recommendations for the Use of Parenteral Methotrexate in Rheumatic Diseases

Author

Tornero Molina, Jesús, Calvo Alen, Jaime, Ballina, Javier, Belmonte, María Ángeles, Blanco, Francisco J., Caracuel, Miguel Ángel, Carbonell, Jordi, Corominas, Héctor, Chamizo, Eugenio, Hidalgo, Cristina, Román Ivorra, José, Marenco, José Luis, Moreno Muelas, José Vicente, Muñoz-Fernández, Santiago, Nolla, Joan M., Pérez, Trinidad, Sanmarti, Raimon, Trenor, Pilar, Urrego, Claudia, Vidal, Javier, and Gomez de Salazar, José Rosas

Published
2018
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18. Recomendaciones sobre el uso de metrotexato parenteral en enfermedades reumáticas

Author

Tornero Molina, Jesús, Calvo Alen, Jaime, Ballina, Javier, Belmonte, María Ángeles, Blanco, Francisco J., Caracuel, Miguel Ángel, Carbonell, Jordi, Corominas, Héctor, Chamizo, Eugenio, Hidalgo, Cristina, Ivorra, José Román, Marenco, José Luis, Moreno Muelas, José Vicente, Muñoz-Fernández, Santiago, Nolla, Joan M., Pérez, Trinidad, Sanmarti, Raimon, Trenor, Pilar, Urrego, Claudia, Vidal, Javier, and Rosas Gomez de Salazar, José

Published
2018
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21. Lipoprotein(a) concentrations in rheumatoid arthritis on biologic therapy: Results from the CARdiovascular in rheuMAtology study project

Author

de Rábago, Eugenia Gonzalez, Blanco Morales, Elena Alonso, Fernández López, J. Carlos, Villar, Natividad Oreiro, Sandoval, Antonio Atanes, Blanco García, Francisco J., De Miquel, Cayetano Alegre, González Fernández, María J., Codina, Ramón Huguet, Yoldi, Beatriz, Ramentol, Mercedes, Ávila, Gabriela, Barril, Sara Marsal, Steiner, Martina, Muñoz, Santiago, Gamero, Fernando, Torón, José García, Moreno Gil, María P., Mas, Antonio J., Espiño, Pilar, Ros, Inmaculada, Ibañez, Mónica, Murillo, Claudia, Piqueras, José A., Sanmartí, Raimon, Berman, Horacio, Cabrera, Sonia, Ruiz, Virginia, Patón, Oscar Fontseré, Gutiérrez, Benjamín Fernández, Abasolo, Lydia, Fábregas, María D., Nolla, Joan M., Arias, Miriam García, García Vadillo, Jesús A., de Vicuña, Rosario García, Nebro, Antonio Fernández, Belmonte López, Maria Angeles, Ureña, Inmaculada, Irigoyen, María V., Cagigal, Virginia Coret, González, Ruth López, Garrido, Daniel Pielfort, Alvarez, Juana Sampedro, García Aparicio, Ángel María, Gómez, Rebeca Belmonte, Bautista, Pastora Granados, Sanz, Azucena Hernández, Sánchez González, Carmen O., Bachiller, Javier, Zea, Antonio, Manero, Francisco J., Zorzo, Fernando Jimenez, Ubeda, Eugenio Giménez, Gracía, Jesús Marzo, Audera, Chesús Beltrán, Medrano, Marta, Pecondón, Ángela, Erausquin, Celia, Ojeda, Soledad, Quevedo, Juan Carlos, Francisco, Félix, Lozano, Carlos Rodríguez, Herráez, Jesús Babío, López Longo, Francisco J., Gerona, Delia, Fernández, Carlos González, Carreño, Luis, Monteagudo, Indalecio, del Pino, Javier, Sánchez González, María Dolores, Corrales, Alfonso, Peiró, María Enriqueta, Senabre, José M., Rosas, José C., Rotés, Isabel, Moreno, Estefanía, Erra, Alba, Grado, Dolors, Calvo, Javier, Rueda, Amalia, Möller, Ingrid, Rodríguez, Isabel, Barbadillo, Carmen, Raya, Enrique, Morales, Pilar, Nieto, Ana, Jiménez, Inmaculada, magro, Cesar, Escribano, Ana Ruibal, Expósito, Sergio Ros, Nievas, Ginés Sánchez, Navarro, Enrique Júdez, Fernández, Manuela Sianes, García Morales, María Ángeles, Bastero, Isabel Labiano, Consuegra, Gloria García, Palmou, Natalia, Pardo, Silvia Martínez, Pujol, Manel, Alonso, Elena Riera, Salvador, Georgina, Alvarez, Beatriz González, Cantabrana, Alberto, Bustabad, Sagrario, Delgado, Esmeralda, Muñoz, Alejandro, Montero, Sergio Rodríguez, Jiménez, Luis María, Redondo, Javier Rivera, Hernández, Teresa González, González Polo, Francisco J., Almagro, Raúl Menor, Moreno, José M., Serret, Emilio Giner, Barroso, Carla Lannuzzelli, Méndez, Laura Cebrián, Navío, María Teresa, Carballido, Cristina Fernández, Pagán, Encarnación, del Castillo, Pablo Mesa, Naredo, Esperanza, Cruz, Ana, Turrión, Ana, Mateo, Isabel, Sánchez, Julio, Galindo, María, González, Javier García, Collantes, Eduardo, Ruíz, Desireé, Font, Pilar, Bonilla, Gema, Meseguer, Antonio López, Moreno, Manuel J., Martínez, M<ce:sup loc='post">a</ce:sup> José Moreno, Fernández, M<ce:sup loc='post">a</ce:sup> Dolores Beteta, Linares, Luis F., Morcillo, Mercedes, González Gómez, María L., Aramburu, José M., Rivera, Natalia A., Berrizbeitia, Olaia Fernández, García Vivar, María Luz, Riera, Manel, León, Yolanda María, Maymó, Joan, Amirall, Miriam, Escolano, Silvia Iniesta, Serrano, Silvia Sánchez, Lis Bona, María Pilar, Fiter, Jordi, Melón, Julia Fernández, Espadaler, Luis, Maiz, Olga, Belzunegui, Joaquín, Bañegil, Inmaculada, Díaz, César, Valls, Ramón, Castellví, Iván, Bonet, María, Ruzafa, Estefania Moreno, Alen, Jaime Calvo, Sandoval, Trinidad Pérez, Evrard, Eva Revuelta, Godo, Javier R., Espartero, Cruz Fernández, Navarro Blasco, Francisco J., González, José Antonio, Miranda-Filloy, José A., García-Gómez, Carmen, Martín-Martínez, Maria A., Castañeda, Santos, Sanchez-Alonso, Fernando, Uriarte-Ecenarro, Miren, González-Juanatey, Carlos, Romera-Baures, Montserrat, Santos-Rey, José, Pinto-Tasende, José Antonio, Quesada-Masachs, Estefanía, Tornero-Molina, Jesús, Martínez-González, Olga, Cobo-Ibáñez, Tatiana, Chamizo-Carmona, Eugenio, Manrique-Arija, Sara, Fábregas-Canales, Dolores, Díaz-González, Federico, Llorca, Javier, and González-Gay, Miguel A.

Published
2017
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23. Initial Treatment with Biological Therapy in Rheumatoid Arthritis.

Author

Tornero Molina, Jesús, Hernández-Cruz, Blanca, and Corominas, Héctor

Subjects
*BIOTHERAPY, *RHEUMATOID arthritis, *MIDDLE-aged women, *PROGNOSIS, *TUMOR necrosis factors
Abstract

Background: We aimed to analyse the effectiveness, efficiency, and safety of initial treatment with biological therapies in rheumatoid arthritis (RA). Methods: Qualitative study. A group of RA experts was selected. A scoping review in Medline was conducted to analyse the evidence of initial RA treatment with biological therapies. Randomised clinical trials were selected. Two reviewers analysed the articles and compiled the data, whose quality was assessed using the Jadad scale. The experts discussed the review's findings and generated a series of general principles: Results: Seventeen studies were included. Most of the included patients were middle-aged women with early RA (1–7 months) and multiple poor prognostic factors. Initial treatment with TNF-alpha inhibitors combined with methotrexate (MTX) and an IL6R inhibitor (either in mono or combination therapy) is effective (activity, function, radiographic damage, quality of life), safe, and superior to MTX monotherapy in the short and medium term. In the long term, patients who received initial treatment with biologicals presented better results than those whose initial therapy was with MTX. Conclusions: Initial treatment of RA with biological therapies is effective, efficient, and safe in the short, medium, and long term, particularly for patients with poor prognostic factors. [ABSTRACT FROM AUTHOR]

Published
2024
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26. Patient preferences in chronic immune-mediated inflammatory diseases potentially treated with biological drugs: discrete choice analysis using real-world data analysis

Author

Ginard-Vicens, Daniel, Tornero-Molina, Jesús, Fernández-Fuente-Bursón, L, Gómez, ML González, Moreno, E, Salleras, M, Guigini, MA, Burniol-Garcia, A, and Crespo, C

Abstract

Immune-mediated inflammatory diseases (IMIDs) represent a high burden due to their chronicity, high prevalence, and associated comorbidities. Chronic patients’ preferences must be considered in IMIDs treatment and follow-up. The objective of this study was to further understand patient’s preferences in private settings. A literature review was performed to choose the most relevant criteria for patients. A D-efficient discrete choice experiment was designed to elicit preferences of adult patients with IMIDs and potential biological treatment prescription. Participants were collected from private practices (rheumatology, dermatology, and gastroenterology) from February to May 2022. Patients chose between option pairs, characterized by six health-care attributes, as well as monthly out-of-pocket drug price. Responses were analyzed through a conditional logit model. Eighty-seven patients answered the questionnaire. The most frequent pathologies were Rheumatoid Arthritis (31%) and Psoriatic Arthritis (26%). The most relevant criteria were choosing the preferred physician (OR 2.25 [SD0.26]); reducing time until visit with specialist (OR 1.79 [SD0.20]), access through primary care (OR 1.60 [SD0.08]), and an increase in monthly out-of-pocket price from 100€ to 300€ (OR 0.55 [SD0.06]) and to 600€ (OR 0.08 [SD0.02]). Chronic IMIDs patients showed a preference toward a faster, personalized service, even with a trade-off in terms of out-of-pocket price

Published
2023
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27. Longitudinal analysis of blood DNA methylation identifies mechanisms of response to tumor necrosis factor inhibitor therapy in rheumatoid arthritis

Author

Juliá, Antonio, Gómez, Antonio, López-Lasanta, María, Blanco García, Francisco J, Erra, Alba, Fernández-Nebro, Antonio, Juan Mas, Antonio, Pérez-García, Carolina, García Vivar, María Luz, Sánchez-Fernández, Simón, Alperi-López, Mercedes, Sanmartí, Raimon, Ortiz, Ana María, Marras Fernández-Cid, Carlos, Díaz-Torné, César, Moreno, Estefanía, Li, Tianlu, Martínez-Mateu, Sergio H., Absher, Devin M., Myers, Richard M., Tornero Molina, Jesús, Marsal, Sara, Juliá, Antonio, Gómez, Antonio, López-Lasanta, María, Blanco García, Francisco J, Erra, Alba, Fernández-Nebro, Antonio, Juan Mas, Antonio, Pérez-García, Carolina, García Vivar, María Luz, Sánchez-Fernández, Simón, Alperi-López, Mercedes, Sanmartí, Raimon, Ortiz, Ana María, Marras Fernández-Cid, Carlos, Díaz-Torné, César, Moreno, Estefanía, Li, Tianlu, Martínez-Mateu, Sergio H., Absher, Devin M., Myers, Richard M., Tornero Molina, Jesús, and Marsal, Sara

Abstract

[Abstract] Background: Rheumatoid arthritis (RA) is a chronic, immune-mediated inflammatory disease of the joints that has been associated with variation in the peripheral blood methylome. In this study, we aim to identify epigenetic variation that is associated with the response to tumor necrosis factor inhibitor (TNFi) therapy. Methods: Peripheral blood genome-wide DNA methylation profiles were analyzed in a discovery cohort of 62 RA patients at baseline and at week 12 of TNFi therapy. DNA methylation of individual CpG sites and enrichment of biological pathways were evaluated for their association with drug response. Using a novel cell deconvolution approach, altered DNA methylation associated with TNFi response was also tested in the six main immune cell types in blood. Validation of the results was performed in an independent longitudinal cohort of 60 RA patients. Findings: Treatment with TNFi was associated with significant longitudinal peripheral blood methylation changes in biological pathways related to RA (FDR<0.05). 139 biological functions were modified by therapy, with methylation levels changing systematically towards a signature similar to that of healthy controls. Differences in the methylation profile of T cell activation and differentiation, GTPase-mediated signaling, and actin filament organization pathways were associated with the clinical response to therapy. Cell type deconvolution analysis identified CpG sites in CD4+T, NK, neutrophils and monocytes that were significantly associated with the response to TNFi. Interpretation: Our results show that treatment with TNFi restores homeostatic blood methylation in RA. The clinical response to TNFi is associated to methylation variation in specific biological pathways, and it involves cells from both the innate and adaptive immune systems.

Published
2022

28. Consensus Statement of the Spanish Society of Rheumatology on Risk Management of Biologic Therapy in Rheumatic Patients

Author

Gómez Reino, Juan, Loza, Estíbaliz, Andreu, José Luis, Balsa, Alejandro, Batlle, Enrique, Cañete, Juan D., Collantes Estévez, Eduardo, Fernández Carballido, Cristina, Fernández Sueiro, José Luis, García de Vicuña, Rosario, González-Álvaro, Isidoro, González Fernández, Carlos, Juanola, Xavier, Linares, Luis Francisco, Marenco, José Luis, Martín Mola, Emilio, Moreno Ramos, Manuel, Mulero Mendoza, Juan, Muñoz Fernández, Santiago, Queiro, Rubén, Richi Alberti, Patricia, Sanz, Jesús, Tornero Molina, Jesús, Zarco Montejo, Pedro, and Carmona, Loreto

Published
2011
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29. Consenso SER sobre la gestión de riesgo del tratamiento con terapias biológicas en pacientes con enfermedades reumáticas

Author

Reino, Juan Gómez, Loza, Estíbaliz, Andreu, José Luis, Balsa, Alejandro, Batlle, Enrique, Cañete, Juan D., Collantes Estévez, Eduardo, Fernández Carballido, Cristina, Fernández Sueiro, José Luis, García de Vicuña, Rosario, González-Álvaro, Isidoro, González Fernández, Carlos, Juanola, Xavier, Linares, Luis Francisco, Marenco, José Luis, Martín Mola, Emilio, Moreno Ramos, Manuel, Mulero Mendoza, Juan, Muñoz Fernández, Santiago, Queiro, Rubén, Richi Alberti, Patricia, Sanz, Jesús, Tornero Molina, Jesús, Zarco Montejo, Pedro, and Carmona, Loreto

Published
2011
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30. Update of the Consensus Statement of the Spanish Society of Rheumatology on the management of biologic therapies in rheumatoid arthritis

Author

Tornero Molina, Jesús, Sanmartí Sala, Raimon, Rodríguez Valverde, Vicente, Martín Mola, Emilio, Marenco de la Fuente, José Luis, González Álvaro, Isidoro, Muñoz Fernández, Santiago, Gómez-Reino Carnota, Juan, Carreño Pérez, Luis, Batlle Gualda, Enrique, Balsa Criado, Alejandro, Luis Andreu, José, María Álvaro-Gracia, José, Antonio Martínez López, Juan, and Loza Santamaría, Estíbaliz

Published
2010
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31. Actualización del Documento de Consenso de la Sociedad Española de Reumatología sobre el uso de terapias biológicas en la artritis reumatoide

Author

Tornero Molina, Jesús, Sanmartí Sala, Raimon, Rodríguez Valverde, Vicente, Martín Mola, Emilio, Marenco de la Fuente, José Luis, González Álvaro, Isidoro, Muñoz Fernández, Santiago, Gómez-Reino Carnota, Juan, Carreño Pérez, Luis, Batlle Gualda, Enrique, Balsa Criado, Alejandro, Andreu, José Luis, Álvaro-Gracia, José María, Martínez López, Juan Antonio, and Loza Santamaría, Estíbaliz

Published
2010
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38. III Actualización del Consenso de la Sociedad Española de Reumatología sobre terapia biológica en la artritis reumatoide

Author

Rodríguez-Valverde, Vicente, Cáliz Cáliz, Rafael, Álvaro-Gracia Álvaro, José M., Marenco de la Fuente, José L., Mulero Mendoza, Juan, Tornero Molina, Jesús, Andréu Sánchez, J.L., Ballina García, F.J., Batlle Gualda, E., Cañete Crespillo, J.D., Carbonell Abelló, J., Carreño Pérez, L., Figueroa Pedrosa, M., Gómez-Reino Carnota, J., González García, T., Laffon Roca, A., Martín Mola, E., Pascual Gómez, E., Sanmartí Sala, R., Salazar Vallinas, J.M., and Valverde García, J.

Published
2006
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39. Experts document on methotrexate use in combined therapy with biological or targeted synthetic disease modifying drugs in patients with rheumatoid arthritis

Author

Tornero-Molina, Jesús, primary, Alperi-López, Mercedes, additional, Castellví, Ivan, additional, de Agustín-de Oro, Juan José, additional, Escudero, Alejandro, additional, García-Vicuña, Rosario, additional, González-Gay, Miguel Ángel, additional, Hidalgo, Cristina, additional, Rubio, Esteban, additional, Sanmartí, Raimon, additional, Casamira, Núria, additional, and Calvo-Alén, Jaime, additional

Published
2020
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40. Cardiovascular mortality and cardiovascular event rates in patients with inflammatory rheumatic diseases in the CARdiovascular in rheuMAtology (CARMA) prospective study—results at 5 years of follow-up.

Author

Martín-Martínez, María A, Castañeda, Santos, Sánchez-Alonso, Fernando, García-Gómez, Carmen, González-Juanatey, Carlos, Sánchez-Costa, Jesús T, Belmonte-López, María A, Tornero-Molina, Jesús, Santos-Rey, José, González, Carmen O Sánchez, Quesada, Estefanía, Moreno-Gil, María P, Cobo-Ibáñez, Tatiana, Pinto-Tasnde, José A, Babío-Herráez, Jesús, Bonilla, Gema, Juan-Mas, Antonio, Manero-Ruiz, Francisco J, Romera-Baurés, Montserrat, and Bachiller-Corral, Javier

Subjects
CARDIOVASCULAR disease related mortality, CARDIOVASCULAR diseases risk factors, PSORIATIC arthritis, CONFIDENCE intervals, ANKYLOSING spondylitis, CARDIOVASCULAR diseases, DISEASE incidence, RISK assessment, DESCRIPTIVE statistics, PUBLIC hospitals, RHEUMATOID arthritis, RHEUMATISM, LONGITUDINAL method, POISSON distribution, PROPORTIONAL hazards models
Abstract

Objectives To determine cardiovascular (CV) mortality and incidence of the first CV event (CVE) in patients with chronic inflammatory rheumatic diseases (CIRD) after 5 years of follow-up. Methods This is an analysis of the CARdiovascular in rheMAatology (CARMA) study after 5 years of follow-up. It includes patients with RA (n  = 775), AS (n  = 738) and PsA (n  = 721), and individuals without CIRD (n  = 677) attending outpatient rheumatology clinics from 67 public hospitals in Spain. Descriptive analyses were performed for the CV mortality at 5 years. The Systematic COronary Risk Evaluation (SCORE) function at 5 years was calculated to determine the expected risk of CV mortality. Poisson models were used to estimate the incidence rates of the first CVE. Hazard ratios of the risk factors involved in the development of the first CVE were evaluated using the Weibull proportional hazard model. Results Overall, 2382 subjects completed the follow-up visit at 5 years. Fifteen patients died due to CVE. CV deaths observed in the CIRD cohort were lower than that predicted by SCORE risk charts. The highest incidence rate of CVE [7.39 cases per 1000 person-years (95% CI 4.63, 11.18)] was found in PsA patients. However, after adjusting for age, sex and CV risk factors, AS was the inflammatory disease more commonly associated with CVE at 5 years [hazard ratio 4.60 (P  =0.02)], compared with those without CIRD. Conclusions Cardiovascular mortality in patients with CIRD at 5 years of follow-up is lower than estimated. Patients with AS have a higher risk of developing a first CVE after 5 years of follow-up. [ABSTRACT FROM AUTHOR]

Published
2021
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41. Recommendations for the use of parenteral methotrexate in rheumatology

Author

Tornero Molina, Jesús, Calvo Alén, Jaime, Ballina, Javier, Belmonte, María Ángeles, Blanco, Francisco J., Caracuel, Miguel Ángel, Carbonell, Jordi, Corominas, Héctor, Chamizo, Eugenio, Hidalgo, Cristina, Román Ivorra, José Andrés, Marenco, José Luis, Moreno Muelas, José Vicente, Muñoz Fernández, Santiago, Nolla, Joan M., Pérez, Trinidad, Sanmartí, Raimon, Trenor, Pilar, Urrego Laurín, Claudia, Vidal, Javier, and Rosas Gómez de Salazar, José

Subjects
Medicamento, Reumatología - Enfermedades, Medicamentos, Enfermedades reumáticas, Metrotexato, Enfermedad
Abstract

Desarrollar recomendaciones sobre el uso de metrotexato (MTX) parenteral en pacientes con enfermedades reumáticas, fundamentalmente en la artritis reumatoide, basadas en la mejor evidencia y experiencia. Métodos Se seleccionó un grupo de 21 expertos reumatólogos en el manejo de MTX. El coordinador generó 13 preguntas sobre el uso de MTX parenteral (perfiles de indicación, eficacia, seguridad, costo-eficacia y biodisponibilidad) para ser contestadas mediante una revisión sistemática de la literatura. Con base en las preguntas se definieron los criterios de inclusión y exclusión, y las estrategias de búsqueda (en Medline, EMBASE y la Cochrane Library). Tres revisores seleccionaron los artículos resultantes de la búsqueda. Se generaron tablas de evidencia. Paralelamente se evaluaron abstracts de congresos de la European League Against Rheumatism (EULAR) y del American College of Rheumatology (ACR). Con toda esta evidencia el coordinador generó 13 recomendaciones preliminares que se evaluaron, discutieron y votaron en una reunión del grupo nominal con los expertos. Para cada recomendación se estableció el nivel de evidencia y grado de recomendación, y el grado de acuerdo mediante un Delphi. Se definió acuerdo si al menos el 80% de los participantes contestaron sí a la recomendación (sí o no). Resultados La mayoría de la evidencia proviene de la artritis reumatoide. De las 13 recomendaciones preliminares se aceptaron 11 recomendaciones sobre el uso de MTX parenteral en reumatología. Dos no se llegaron a votar y se decidió no incluirlas, pero se comentan en el texto final. Conclusiones Este documento pretende resolver algunos interrogantes clínicos habituales y facilitar la toma de decisiones con el uso de MTX parenteral. To develop recommendations for the use of parenteral methotrexate (MTX) in rheumatic diseases, mainly rheumatoid arthritis, based on best evidence and experience. Methods A group of 21 experts on parenteral MTX use was selected. The coordinator formulated 13 questions about parenteral MTX (indications, efficacy, safety and cost-effectiveness). A systematic review was conducted to answer the questions. Using this information, inclusion and exclusion criteria were established, as were the search strategies (involving Medline, EMBASE and the Cochrane Library). Three different reviewers selected the articles. Evidence tables were created. Abstracts from the European League Against Rheumatism (EULAR) and American College of Rheumatology (ACR) were evaluated. Based on this evidence, the coordinator proposed preliminary recommendations that the experts discussed and voted in a nominal group meeting. The level of evidence and grade of recommendation were established using the Oxford Center for Evidence-Based Medicine and the level of agreement with the Delphi technique (2 rounds). Agreement was established if at least 80% of the experts voted yes (yes/no). Results Most of the evidence involved rheumatoid arthritis. A total of 13 preliminary recommendations on the use of parenteral MTX were proposed; 11 of them were accepted. Two of the 13 were not voted and are commented on in the main text. Conclusions The manuscript aims to solve frequent questions and help in decision-making strategies when treating patients with parenteral MTX. Sin financiación No data JCR 2018 0.363 SJR (2018) Q3, 38/66 Rheumatology No data IDR 2018 UEM

Published
2017

42. Colaboradores

Author

Abalovich, Marcos S., Adamo, Bárbara, García-Navarro, Alvar Agustí, García-Navarro, Carlos Agustí, Alcalá Hernández, Luis, Alcaraz Asensio, Antonio, Alcázar Arroyo, Roberto, Alegre de Miquel, Víctor, Almirante Gragera, Benito, Alonso Fernández, Pedro Luis, Alonso Pérez, Manuel, Alonso Tarrés, Carles, Alsina Gibert, Mercè, Alsina Manrique de Lara, Laia, José Álvarez Martínez, Miriam, Luis Álvarez-Sala Walther, José, Álvarez Twose, Iván, Ambrosioni Czyrko, Juan, Ancochea Bermúdez, Julio, Andrade Bellido, Raúl J., Antón López, Jordi, Antón Nieto, Esperanza, Aran Perramon, Josep Maria, Arance Fernández, Ana, Arboleya Rodríguez, Luis, Arias Gómez, Manuel, Ariza Cardenal, Xavier, Armengol Dulcet, Lluís, Aróstegui Gorospe, Juan Ignacio, Arranz Amo, José Antonio, Arrese, Marco, Arribas López, José Ramón, Audí Parera, Laura, Aulinas Masó, Anna, Azpiroz Vidaur, Fernando, Ramon Badia Jobal, Joan, Badimon Maestro, Lina, Baena Caparrós, Jacinto, Martínez de Irujo, Jaume Baldirà, Barbé Illa, Ferran, Barberà Mir, Joan Albert, Barberán López, José, Barile Fabrís, Leonor, Bartra Tomás, Joan, Bassas Arnau, Lluís, Bassat, Quique, Bataller Alberola, Luis, Bataller Alberola, Ramon, Bayés Colomer, Mónica, Berdasco Menéndez, María, Bernabeu Morón, Ignacio, Bernardo Arroyo, Miquel, Berraondo López, Pedro, Berzigotti, Annalisa, Bielsa Marsol, Isabel, Bladé Creixenti, Joan, Blanco Arévalo, José Luis, Blanco García, Francisco Javier, Blanco Vich, Isabel, Blasco Pelicano, Miquel, Blesa González, Rafael, Bodegas Cañas, Andrés Ignacio, Bodro Marimont, Marta, Boronat Guerrero, Susana, Borràs Andrés, Josep Maria, Borrego Rabasco, Francisco, Bosch Genover, Xavier, Bosch Mestres, Jordi, Botey Puig, Albert, Bouza Santiago, Emilio, Brugada Terradellas, Josep, Brugada Terradellas, Ramon, Bruix Tudó, Jordi, Bruna Escuer, Jordi, Buján Rivas, Segundo, Fernández de Piérola, Luis Bujanda, Burgos Rincón, Felip, Buti Ferret, María, Caballería Rovira, Joan, Cabellos Mínguez, Carmen, Cahn, Pedro, Calvet Calvo, Xavier, Campins Martí, Magda, Campistol Plana, Josep M.ª, Campo Güerri, Elías, Campuzano Larrea, Óscar, Campuzano Uceda, Victoria, Cardellach López, Francesc, Carmena Rodríguez, Rafael, Carmona Herrera, Francisco, Carracedo Álvarez, Ángel, Carracedo Pérez, Arkaitz, Carreres Molas, Anna, Casabona i Barbarà, Jordi, Casademont Pou, Jordi, Casanueva Freijo, Felipe F., Cases Amenós, Aleix, Castells Garangou, Antoni, Castelo-Branco, Camil, Castón Osorio, Juan José, Castro Fornieles, Josefina, Castro Rebollo, Pedro, Catalán Eraso, Beatriz, Caylà Buqueras, Joan A., Cervantes Requena, Francisco, Cervera Álvarez, Carlos, Cervera Segura, Ricard, Chamorro Sánchez, Ángel, Cid Xutglà, María Cinta, Cinca Cuscullola, Juan María, Coll Daroca, Joaquim, José Coll Rosell, M.ª, Colmenero Arroyo, Jordi, Compta Hirnyi, Yaroslau, Conesa Bertrán, Gerardo, Corell Almuzara, Alfredo, Crespo Casal, Manuel, Crespo Conde, Gonzalo, Crespo García, Javier, Cristòfol Allué, Ramon, Cigudosa García, Juan Cruz, Cubiella Fernández, Joaquín, Cuenca Estrella, Manuel, Cuevas Esteban, Jorge, Dalmau Obrador, Josep, Davant Llauradó, Ester, Iserte, Alejandro de la Sierra, Pascual, Enrique de Madaria, Rabassó, Joan de Pablo, Galván, Eduardo de Teresa, Casanelles, Miguel del Campo, Bueno, Ana del Río, Delgado González, Julio, Diekmann, Fritz, Domínguez Benítez, José Antonio, Domínguez García, Ángela, Domínguez Luengo, Carmen, Ángeles Domínguez Luzón, M.ª, Jesús Domínguez Tordable, M.ª, Dopazo Blázquez, Joaquín, Dueñas Laita, Antonio, Durán Rebolledo, Carlos Eduardo, Duró Pujol, Joan Carles, Echevarría Mayo, Juan Emilio, Eiros Bouza, José M.ª, Ignaci Elizalde Frez, J., Embid López, Cristina, Engel Rocamora, Pablo, de Salamanca Lorente, Rafael Enríquez, Escorsell Mañosa, Àngels, España Alonso, Agustín, Esteban Mur, Rafael, Esteller Badosa, Manel, Esteve Comas, María, Esteve Pardo, María, Esteve Reyner, Jordi, Estruch Riba, Ramón, Fainboim, Leonardo, Feliu Frasnedo, Evarist, Fernández Bañares, Fernando, Fernández Fernández, Óscar, Fernández Gómez, Javier, Fernández Llama, Patricia, Ferrándiz Foraster, Carlos, Ferrer Monreal, Miguel, Figuerola Pino, Daniel, Fillat Fonts, Cristina, Fonollosa Pla, Vicent, Fontanellas Romá, Antonio, Forcada Vega, Carme, Forner González, Alejandro, Forns Bernhardt, Xavier, Fortuny Guasch, Claudia, Franco de Castro, Agustín, Fresno Escudero, Manuel, Fullana Rivas, Miquel A., Gaba García, Lydia, Gaig Ventura, Carles, Galarza Delgado, Dionicio Ángel, Galicia Paredes, Miguel, Gállego Culleré, Montserrat, García de Vinuesa, Pastora Gallego, Garcia-Esteve, Lluïsa, García Lareo, Manuel, García-Moncó, Juan Carlos, García Nieto, Víctor, García-Pagán, Juan Carlos, García Sánchez, José Elías, Garrido Marín, Eduardo, Gascón Brustenga, Joaquim, Gatell Artigas, Josep M.ª, Gaztambide Sáenz, Sonia, Genescà Ferrer, Joan, Giavina-Bianchi, Pedro, Gil de Extremera, Blas, Giménez Pérez, Montserrat, Giné Soca, Eva, Ginès Gibert, Pere, Goday Arnó, Albert, Gómez-Batiste Alentorn, Xavier, Gómez Dantés, Héctor, Gómez Gil, Esther, Gomollón García, Fernando, Xavier González Argenté, F., González Juanatey, José Ramón, González Macías, Jesús, González Martín, Julià, González Tugas, Matías, Gracia Guillén, Diego, Grande i Fullana, Iria, Grau de Castro, Juan José, Grau Junyent, Josep M.ª, García-Milà, Isabel Graupera, Graus Ribas, Francesc, Gual Solé, Antoni, Guañabens Gay, Nuria, Gurguí Ferrer, Mercè, Ponce de León, Fernando Gutiérrez, Halperin Rabinovich, Irene, Alexandra Hanzu, Felicia, Hawkins Carranza, Federico G., Hernández García, Miguel Teodoro, Hernández Gea, Virginia, Hernández Rodríguez, José, Herrero Santos, José Ignacio, Ibáñez Toda, Lourdes, Illa Sendra, Isabel, Iranzo de Riquer, Alejandro, Pérez de Guzmán, Dolores Jaraquemada, Jiménez Castro, David, Juan Otero, Manuel, Juanola Roura, Xavier, Kalil, Jorge, Khamashta, Munther A., Labarca Labarca, Jaime, Laborde, Amalia, Lanas Arbeloa, Ángel, Landete Rodríguez, Pedro, Larrosa Escartín, Nieves, Lens García, Sabela, Carlota Londoño, Maria, Bernaldo de Quirós, Juan Carlos López, López de Sá, Esteban, López Guillermo, Armando, López-Sendón, José, López-Vélez Pérez, Rogelio, Lozano Sánchez, Francisco S., Lozano Soto, Francisco, Lumbreras Bermejo, Carlos, Mallolas Masferrer, Josep, Manzanera López, Rafael, Mañá Rey, Juan, Marco Reverté, Francesc, Ángeles Marcos Maeso, M.ª, Marimón Ortiz de Zarate, José María, Mariño Méndez, Zoe, Maroñas Amigo, Olalla, Marrades Sicart, Ramon M.ª, Marrugat de la Iglesia, Jaume, Martí Domènech, María Josep, Martí Mestre, Francesc Xavier, Martí Ripoll, Mercè, Cristina Martín Sierra, M.ª, Martínez Díaz-Guerra, Guillermo, Martínez-Lavín, Manuel, Martínez Martínez, José Antonio, Martínez Valle, Fernando, Martínez Vea, Alberto, Martínez Yoldi, Miguel Julián, Martorell Pons, Jaume, Mas Capó, Jordi, Masana Marín, Lluís, Masana Montejo, Guillem, Mascaró Galy, José Manuel, Matas Andreu, Lurdes, Maurel Santasusana, Joan, Melero Bermejo, Ignacio, Melero Maseda, Marcelo José, Mellado González, Begoña, Mensa Pueyo, José, Mercé Klein, Jorge, Mestres Alomar, Gaspar, Milà Recasens, Montserrat, Milone, Jorge H., Miralles Basseda, Ramón, Miralles Hernández, Manuel, Miró Meda, José María, Mòdol Deltell, Josep M.ª, Molero Richard, Xavier, Molina Infante, Javier, Molina Molina, María, Molins López-Rodó, Laureano, Mont Girbau, Lluís, Montoro Huguet, Miguel Ángel, Montserrat Canal, Josep Maria, Mora Casterá, Elvira, Mora Porta, Mireia, Morales-Olivas, Francisco, Morales Romero, Blai, Morán Chorro, Indalecio, Morata Ruiz, Laura, Asunción Moreno Camacho, M.ª, Moreno Carriles, Rosa María, Muga Bustamante, Roberto, Muñoz Almagro, Carmen, Muñoz Bermúdez, Rosana, Muñoz García, José Esteban, García-Paredes, Patricia Muñoz, Muñoz Gutiérrez, José, Muñoz Mateu, Montserrat, Muñoz Villegas, Álvaro, África Muxí Pradas, María, Navarro Acebes, Xavier, Navasa Anadón, Miquel, Nicolás Arfelis, José María, Nolla Solé, Joan Miquel, Norman, Francesca F., Obach Baurier, Víctor, Obrador Vera, Gregorio Tomás, Oliva Dámaso, Elena, Olivé Marqués, Alejandro, Oriola Ambròs, Josep, Ortiz Arduan, Alberto, de Lejarazu Leonardo, Raúl Ortiz, Oteo Revuelta, José Antonio, Palau Martínez, Francesc, Pallarés Giner, Román, Palou Rivera, Eduardo, Panés Díaz, Julián, Parés Darnaculleta, Albert, Pascal Capdevila, Mariona, Pascual Gómez, Eliseo, Pascual Gómez, Julio, Pascual Mateos, Juan Carlos, Pedro-Botet Montoya, Juan, Luisa Pedro-Botet Montoya, M.ª, Pereira Saavedra, Arturo, Pérez Gisbert, Javier, Pérez-Jurado, Luis Alberto, Pérez Sáenz, José Luis, Picado de Puig, Albert, Picado Valles, César, Picó Alfonso, Antonio, Pigrau Serrallach, Carlos, Jesús Pinazo Delgado, M.ª, Pintado García, Vicente, Pintos Morell, Guillem, Piñeiro Ibáñez, Daniel José, Piqueras Carrasco, Josep, López de Briñas, Esteban Poch, Pons-Estel, Bernardo A., Pons-Estel, Guillermo J., Pons Lladó, Guillem, Porcel Pérez, José Manuel, Portela Hernández, Margarita, Praga Terente, Manuel, Prat Aparicio, Aleix, Puig Domingo, Manuel, Pujol-Borrell, Ricardo, Pulido Mestre, Marta, Pumarola Suñé, Tomàs, Puras Mallagray, Enrique, Quintana Porras, Luis F., Quintero Carrión, Enrique, Adrián Rabinovich, Gabriel, Rabionet Janssen, Raquel, Ramos Casals, Manuel, Raya Sánchez, José María, Rego Castro, Maria José, Reguart Aransay, Noemí, Reverter Calatayud, Joan Carles, Reverter Calatayud, Jorge Luis, Reyes Moreno, José, Riambau Alonso, Vicente, Ribera Casado, José Manuel, Ribera Santasusana, Josep M.ª, Ribes Rubió, Antonia, Robert Boter, Neus, Roca Lecumberri, Alba, Roca Torrent, Josep, Roche Rebollo, Enric, Gonzalo de Liria, Carlos Rodrigo, Rodríguez Baño, Jesús, Rodríguez de Castro, Felipe, Rodríguez Panadero, Francisco, Rodríguez Pérez, José Carlos, Rodríguez-Roisin, Roberto, Rodríguez Valero, Natalia, Roig Minguell, Eulàlia, Rojas García, Ricardo, Roman Broto, Antonio, Romero Gómez, Manuel, Ros Cerro, Cristina, Rovira Cañellas, Àlex, Rozman, Ciril, Rozman Jurado, María, Ruiz-Argüelles, Guillermo José, Ruiz Granell, Ricardo, Ruiz Manzano, Juan, Ruiz Moreno, Javier, Sabaté Tenas, Manel, Saiz Hinajeros, Albert, Sala Sanjaume, Joan, Salgado García, Emilio, Salinas Vert, Isabel, San Miguel Izquierdo, Jesús F., Sánchez del Valle Díaz, Raquel, Sánchez González, Marcelo, Sánchez Rodríguez, Ángel, Sanmartí Sala, Raimon, Ángel Sanz Alonso, Miguel, Sanz Santillana, Guillermo F., Saperas Franch, Esteban, Saurí Nadal, Tamara, Schwarzstein, Diego, Segura Egea, Antònia, Segura Porta, Ferrán, Sellarés Torres, Jacobo, Selva O’Callaghan, Albert, Serra Majem, Lluís, Serrano Gimaré, Mercedes, Sibila Vidal, Oriol, Sierra Gil, Jorge, Sierra Romero, Gustavo Adolfo, Sitges Carreño, Marta, Solà Vergés, Elsa, Solana Lara, Rafael, Solans Laqué, Roser, Gloria Soldevila Melgarejo, M.ª, Soler Porcar, Néstor, Sopena Galindo, Nieves, Soriano Viladomiu, Álex, Soy Muner, Dolors, Suárez Fernández, Ricardo, Suela Rubio, Javier, Targarona Soler, Eduardo M.ª, Tejedor Jorge, Alberto, Tolosa Sarró, Eduardo, Tornero Molina, Jesús, Tornos Mas, Pilar, Torra Balcells, Roser, Torregrosa Prats, José Vicente, Torres Hortal, Montserrat, Torres Martí, Antoni, Torres Ramírez, Armando, Torrico, Faustino, Trilla García, Antoni, Tuca Rodríguez, Albert, Tudela Hita, Pere, Urbano Ispizua, Álvaro, Urrutia de Diego, Agustín, Valero Santiago, Antonio Luis, Valle Velasco, Laura, Eugenia Valls Lolla, M.ª, Valls Solé, Josep, Vaquero Raya, Eva C., Varsavsky, Mariela, Vázquez Martínez, Clotilde, San Miguel, Federico Vázquez, Vázquez Zaragoza, Miguel Ángel, Vicente García, Vicente, Vidal Bermúdez, José Ernesto, Vidal Losada, Maria, Vidal-Puig, Antonio, Vieta Pascual, Eduard, Vila Estapé, Jordi, Vilardell Tarrés, Miquel, Vilaseca González, Isabel, Vilella i Morató, Anna, Villà i Freixa, Salvador, Villabona Artero, Carles, Villamor Casas, Neus, Vinuesa Aumedes, Teresa, Viñolas Segarra, Nuria, Vives Corrons, Joan Lluís, Volberg Vincent, Veronica Inés, Vollmer Torrubiano, Ivan, Webb Youdale, Susan M., Yagüe Ribes, Jordi, Yugueros Castellnou, Xavier, and Zarranz Imirizaldu, Juan José

Published
2020
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43. Lipoprotein(a) concentrations in rheumatoid arthritis on biologic therapy: Results from the CARdiovascular in rheuMAtology study project

Author

García-Gómez, Carmen, primary, Martín-Martínez, Maria A., additional, Castañeda, Santos, additional, Sanchez-Alonso, Fernando, additional, Uriarte-Ecenarro, Miren, additional, González-Juanatey, Carlos, additional, Romera-Baures, Montserrat, additional, Santos-Rey, José, additional, Pinto-Tasende, José Antonio, additional, Quesada-Masachs, Estefanía, additional, Tornero-Molina, Jesús, additional, Martínez-González, Olga, additional, Cobo-Ibáñez, Tatiana, additional, Chamizo-Carmona, Eugenio, additional, Manrique-Arija, Sara, additional, Fábregas-Canales, Dolores, additional, Díaz-González, Federico, additional, Llorca, Javier, additional, González-Gay, Miguel A., additional, de Rábago, Eugenia Gonzalez, additional, Blanco Morales, Elena Alonso, additional, Fernández López, J. Carlos, additional, Villar, Natividad Oreiro, additional, Sandoval, Antonio Atanes, additional, Blanco García, Francisco J., additional, De Miquel, Cayetano Alegre, additional, González Fernández, María J., additional, Codina, Ramón Huguet, additional, Yoldi, Beatriz, additional, Ramentol, Mercedes, additional, Ávila, Gabriela, additional, Barril, Sara Marsal, additional, Steiner, Martina, additional, Muñoz, Santiago, additional, Gamero, Fernando, additional, Torón, José García, additional, Moreno Gil, María P., additional, Mas, Antonio J., additional, Espiño, Pilar, additional, Ros, Inmaculada, additional, Ibañez, Mónica, additional, Murillo, Claudia, additional, Piqueras, José A., additional, Sanmartí, Raimon, additional, Berman, Horacio, additional, Cabrera, Sonia, additional, Ruiz, Virginia, additional, Patón, Oscar Fontseré, additional, Gutiérrez, Benjamín Fernández, additional, Abasolo, Lydia, additional, Fábregas, María D., additional, Nolla, Joan M., additional, Arias, Miriam García, additional, García Vadillo, Jesús A., additional, de Vicuña, Rosario García, additional, Nebro, Antonio Fernández, additional, Belmonte López, Maria Angeles, additional, Ureña, Inmaculada, additional, Irigoyen, María V., additional, Cagigal, Virginia Coret, additional, González, Ruth López, additional, Garrido, Daniel Pielfort, additional, Alvarez, Juana Sampedro, additional, García Aparicio, Ángel María, additional, Gómez, Rebeca Belmonte, additional, Bautista, Pastora Granados, additional, Sanz, Azucena Hernández, additional, Sánchez González, Carmen O., additional, Bachiller, Javier, additional, Zea, Antonio, additional, Manero, Francisco J., additional, Zorzo, Fernando Jimenez, additional, Ubeda, Eugenio Giménez, additional, Gracía, Jesús Marzo, additional, Audera, Chesús Beltrán, additional, Medrano, Marta, additional, Pecondón, Ángela, additional, Erausquin, Celia, additional, Ojeda, Soledad, additional, Quevedo, Juan Carlos, additional, Francisco, Félix, additional, Lozano, Carlos Rodríguez, additional, Herráez, Jesús Babío, additional, López Longo, Francisco J., additional, Gerona, Delia, additional, Fernández, Carlos González, additional, Carreño, Luis, additional, Monteagudo, Indalecio, additional, del Pino, Javier, additional, Sánchez González, María Dolores, additional, Corrales, Alfonso, additional, Peiró, María Enriqueta, additional, Senabre, José M., additional, Rosas, José C., additional, Rotés, Isabel, additional, Moreno, Estefanía, additional, Erra, Alba, additional, Grado, Dolors, additional, Calvo, Javier, additional, Rueda, Amalia, additional, Möller, Ingrid, additional, Rodríguez, Isabel, additional, Barbadillo, Carmen, additional, Raya, Enrique, additional, Morales, Pilar, additional, Nieto, Ana, additional, Jiménez, Inmaculada, additional, magro, Cesar, additional, Escribano, Ana Ruibal, additional, Expósito, Sergio Ros, additional, Nievas, Ginés Sánchez, additional, Navarro, Enrique Júdez, additional, Fernández, Manuela Sianes, additional, García Morales, María Ángeles, additional, Bastero, Isabel Labiano, additional, Consuegra, Gloria García, additional, Palmou, Natalia, additional, Pardo, Silvia Martínez, additional, Pujol, Manel, additional, Alonso, Elena Riera, additional, Salvador, Georgina, additional, Alvarez, Beatriz González, additional, Cantabrana, Alberto, additional, Bustabad, Sagrario, additional, Delgado, Esmeralda, additional, Muñoz, Alejandro, additional, Montero, Sergio Rodríguez, additional, Jiménez, Luis María, additional, Redondo, Javier Rivera, additional, Hernández, Teresa González, additional, González Polo, Francisco J., additional, Almagro, Raúl Menor, additional, Moreno, José M., additional, Serret, Emilio Giner, additional, Barroso, Carla Lannuzzelli, additional, Méndez, Laura Cebrián, additional, Navío, María Teresa, additional, Carballido, Cristina Fernández, additional, Pagán, Encarnación, additional, del Castillo, Pablo Mesa, additional, Naredo, Esperanza, additional, Cruz, Ana, additional, Turrión, Ana, additional, Mateo, Isabel, additional, Sánchez, Julio, additional, Galindo, María, additional, González, Javier García, additional, Collantes, Eduardo, additional, Ruíz, Desireé, additional, Font, Pilar, additional, Bonilla, Gema, additional, Meseguer, Antonio López, additional, Moreno, Manuel J., additional, Martínez, Ma José Moreno, additional, Fernández, Ma Dolores Beteta, additional, Linares, Luis F., additional, Morcillo, Mercedes, additional, González Gómez, María L., additional, Aramburu, José M., additional, Rivera, Natalia A., additional, Berrizbeitia, Olaia Fernández, additional, García Vivar, María Luz, additional, Riera, Manel, additional, León, Yolanda María, additional, Maymó, Joan, additional, Amirall, Miriam, additional, Escolano, Silvia Iniesta, additional, Serrano, Silvia Sánchez, additional, Lis Bona, María Pilar, additional, Fiter, Jordi, additional, Melón, Julia Fernández, additional, Espadaler, Luis, additional, Maiz, Olga, additional, Belzunegui, Joaquín, additional, Bañegil, Inmaculada, additional, Díaz, César, additional, Valls, Ramón, additional, Castellví, Iván, additional, Bonet, María, additional, Ruzafa, Estefania Moreno, additional, Alen, Jaime Calvo, additional, Sandoval, Trinidad Pérez, additional, Evrard, Eva Revuelta, additional, Godo, Javier R., additional, Espartero, Cruz Fernández, additional, Navarro Blasco, Francisco J., additional, González, José Antonio, additional, and Miranda-Filloy, José A., additional

Published
2017
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44. Efectos de la intervención desde terapia ocupacional sobre la percepción del dolor crónico y la calidad de vida en pacientes con artritis reumatoide

Author

Moreno Rodríguez, Ricardo, García Vicuña, Rosario, Goicoechea García, Carlos, Tornero Molina, Jesús, Moreno Rodríguez, Ricardo, García Vicuña, Rosario, Goicoechea García, Carlos, and Tornero Molina, Jesús

Abstract

Objectives: To determine if an occupational therapy based intervention focused on performance reorganization on patients with rheumatoid arthritis reduces pain and improves self-efficacy and quality of life. Material and methods: Randomized controlled intervention study through a group program of seven occupational therapy sessions, conducted in five weeks. Results: We found an improvement in self-efficacy (p<0,001) and quality of life scores (p = 0,001, p = 0,08), as well as pain intensity MPQ (McGill Pain Questionnaire) measures, although the values collected with VAS (visual analogue scale) maintained over time. Conclusions: The program was effective in changing the studied variables, although a new study with a larger sample is required., Objetivos: determinar si una propuesta de intervención experimental desarrollada desde el campo de trabajo de la terapia ocupacional, dirigida a la reestructuración del desempeño ocupacional en pacientes con artritis reumatoide, reduce los niveles de dolor percibidos y mejora la autoeficacia y la calidad de vida de los mismos. Esta intervención se llevó a cabo de forma grupal, utilizando modelos de formación y enseñanza de estrategias a los pacientes. Material y método: estudio de intervención controlado aleatorizado de un programa grupal de terapia ocupacional de siete sesiones, de dos horas cada una, realizadas en cinco semanas. Resultados: se detectó una mejora en las puntuaciones de autoeficacia (p < 0,001) y de calidad de vida (p = 0,001; p = 0,08), así como de las puntuaciones de intensidad de dolor medidas con MPQ (McGill Pain Questionnaire), aunque los valores recogidos con EVA (escala visual analógica) se mantienen en el tiempo. Conclusiones: el programa resultó eficaz en la modificación de las variables estudiadas, apreciándose cambios significativos tanto en intensidad de dolor, como en los valores referidos a autoeficacia y calidad de vida. Es recomendable repetir el trabajo con una muestra mayor que permita obtener datos más consistentes.

Published
2015

47. Colaboradores

Author

Abalovich, Marcos S., Agustí García-Navarro, Álvaro, Agustí García-Navarro, Carlos, Albanell Mestres, Joan, Alcalá Hernández, Luis, Alcaraz Asensio, Antonio, Alcázar Arroyo, Roberto, Alegre de Miquel, Víctor, Alexandra Hanzu, Felicia, Almirante Gragera, Benito, Alonso Tarrés, Carles, Alsina Gibert, Mercè, Alsina Manrique de Lara, Laia, Álvarez Martínez, Miriam José, Álvarez-Sala Walther, José Luis, Ambrosioni Czyrko, Juan, Ancochea Bermúdez, Julio, Andrade Bellido, Raúl J., Antón López, Jordi, Aran Perramon, Josep Maria, Arance Fernández, Ana, Arboleya Rodríguez, Luis, Arellano Tolivar, Antonio, Arias Gómez, Manuel, Arias Loste, M.ª Teresa, Ariza Cardenal, Javier, Armengol Dulcet, Lluís, Aróstegui Gorospe, Juan Ignacio, Arrese, Marco, Arroyo Pérez, Vicente, Aschner Montoya, Pablo, Audí Parera, Laura, Azpiroz Vidaur, Fernando, Badimon Maestro, Lina, Baena Caparrós, Jacinto, Ballester Rodés, Eugenio, Ballina García, Francisco Javier, Barberà Mir, Joan Albert, Barberán López, José, Barile Fabris, Leonor, Bartra Tomás, Joan, Bassas Arnau, Lluís, Bassat Orellana, Quique, Bataller Alberola, Luis, Bayés Colomer, Mónica, Bernardo Arroyo, Miquel, Berraondo López, Pedro, Bielsa Marsol, Isabel, Bladé Creixentí, Joan, Blancafort Sansó, Xavier, Blanco Arévalo, José Luis, Blanco García, Francisco J., Blanes Mompó, José Ignacio, Blesa González, Rafael, Bodegas Cañas, Andrés Ignacio, Bodro Marimont, Marta, Boronat Guerrero, Susana, Bosch Albareda, Francesc, Bosch Genover, Jaime, Bosch Genover, Xavier, Bosch Gil, José Ángel, Bosch Mestres, Jordi, Botey Puig, Albert, Bouza Santiago, Emilio, Bru Saumell, Concepció, Brugada Terradellas, Josep, Brugada Terradellas, Ramon, Bruguera Cortada, Miquel, Bruix Tudó, Jordi, Bujanda Fernández de Piérola, Luis, Buti Ferret, María, Caballería Rovira, Joan, Cabellos Mínguez, Carmen, Cahn, Pedro, Calvet Calvo, Xavier, Calzado Isbert, Sonia, Campins Martí, Magda, Campistol Plana, Josep M.ª, Campo Casanelles, Miguel del, Campo Güerri, Elías, Campuzano Larrea, Óscar, Campuzano Uceda, Victoria, Cardellach López, Francesc, Carmena Rodríguez, Rafael, Carmona Herrera, Francisco, Carracedo Álvarez, Ángel, Carrascosa Lezcona, Antonio, Carreres Molas, Anna, Carreras Pons, Enric, Casabona i Barbarà, Jordi, Casademont Pou, Jordi, Casanueva, Felipe F., Cases Amenós, Aleix, Castells Garangou, Antoni, Castro Fornieles, Josefina, Castro Rebollo, Pedro, Catalán Eraso, Beatriz, Caylà Buqueras, Joan A., Cervantes Requena, Francisco, Cervera Segura, Ricardo, Cervera Álvarez, Carlos, Chamorro Sánchez, Ángel, Cinta Cid Xutglà, María, Cinca Cuscullola, Juan M.ª, Coll Daroca, Joaquím, Coll Rosell, M.ª José, Colmenero Arroyo, Jordi, Conesa Bertrán, Gerardo, Corell Almuzara, Alfredo, Crespo Casal, Manuel, Crespo Conde, Gonzalo, Crespo García, Javier, Cristòfol Allué, Ramon, Cubiella Fernández, Joaquín, Cuenca Estrella, Manuel, Dalmau Obrador, Josep, Davant Llauradó, Ester, Delgado González, Julio, Desola Alà, Jordi, Diekmann, Fritz, Dolz Abadía, Carlos, Domínguez Benítez, José Antonio, Domínguez García, Ángela, Domínguez Luengo, Carmen, Domínguez Luzón, M.ª Ángeles, Domínguez Tordable, M.ª Jesús, Dopazo Blázquez, Joaquín, Dueñas Laita, Antonio, Durán Rebolledo, Carlos Eduardo, Duró Pujol, Juan Carlos, Echevarría Mayo, José Manuel, Echevarria Mayo, Juan Emilio, Eiros Bouza, José M.ª, Elizalde Frez, José Ignacio, Engel Rocamora, Pablo, Enrique Cahn, Pedro, Enríquez de Salamanca Lorente, Rafael, Escorsell Mañosa, Àngels, Escribano Mora, Luis, Estapé Madinabeitia, Tania, Estapé Rodríguez, Jordi, Esteban Mur, Rafael, Esteller Badosa, Manel, Esteve Comas, María, Esteve Pardo, María, Esteve Reyner, Jordi, Estivill Pallejà, Xavier, Estruch Riba, Ramón, Fainboim, Leo, Feliu Frasnedo, Evarist, Fernández Bañares, Fernando, Fernández Fernández, Óscar, Fernández Gómez, Javier, Fernández-Tresguerres Hernández, Jesús Ángel, Ferrándiz Foraster, Carlos, Ferrer Monreal, Miguel, Figuerola Pino, Daniel, Fillat Fonts, Cristina, Fonollosa Pla, Vincent, Fonseca Capdevila, Eduardo, Font Creus, Bernat, Fontanellas Romá, Antonio, Forns Bernhardt, Xavier, Fortuny Guasch, Claudia, Franco de Castro, Agustín, Franco Vásquez, José G., Fresno Escudero, Manuel, Galarza Delgado, Dionicio Ángel, Galicia Paredes, Miguel, Gállego Culleré, Montserrat, Gallego García de Vinuesa, Pastora, Gárate Ormaechea, Teresa, García Lareo, Manuel, Carlos García Moncó, Juan, García Nieto, Víctor M., García-Pagán, Juan Carlos, García Sánchez, José Elías, García-Zepeda, Eduardo Alberto, Garrido Marín, Eduardo, Gascón Brustenga, Joaquim, Gatell Artigas, Josep M.ª, Gaztambide Sáenz, Sonia, Giavina-Bianchi, Pedro, Gil de Extremera, Blas, Giménez Pérez, Montserrat, Ginès Gibert, Pere, Girós Blasco, M.ª Luisa, Goday Arnó, Albert, Gómez Dantés, Héctor, Gómez Gil, Esther, Gómez Junyent, Joan, Gómez Sáez, José Manuel, Gómez-Batiste Alentorn, Xavier, Gomollón García, Fernando, González Argenté, Francesc Xavier, González Juanatey, José Ramón, González Macías, Jesús, González Martín, Julià, González Tugas, Matías, Gonzalo de Liria, Carlos Rodrigo, Gracia Guillén, Diego, Gracia Roldán, Javier de, Grau Junyent, Josep M.ª, Grau de Castro, Juan José, Graus Ribas, Francesc, Gual Solé, Antoni, Guañabens Gay, Núria, Guardiola Ponti, Helena, Gurguí Ferrer, Mercè, Gutiérrez Julián, José M.ª, Gutiérrez Ponce de León, Fernando, Halperin Rabinovich, Irene, Hawkins Carranza, Federico G., Hernández García, Miguel T., Hernández-Nieto, Luis, Herrero Santos, José Ignacio, Ibáñez Toda, Lourdes, Illa Sendra, Isabel, Iranzo de Riquer, Alejandro, Jaraquemada Pérez de Guzmán, Dolores, Jové Teixidó, Josep, Juan Otero, Manel, Juanola Roura, Xavier, Kalil, Jorge, Khamashta, Munther, Labarca Labarca, Jaime, Laborde, Amalia, Lanas Arbeloa, Ángel, Larrosa Escartín, Nieves, Liñares Louzao, Josefina, Lobo Satué, Antonio, Londoño, María Carlota, López Bernaldo de Quirós, Juan Carlos, López Guillermo, Armando, López Otín, Carlos, Luis López-Sendón, José, López-Vélez Pérez, Rogelio, Lozano Sánchez, Francisco S., Lozano Soto, Francisco, Lucas Martín, Anna M.ª, Lucas Morante, Tomás, Luis Alonso, Pedro, Lumbreras Bermejo, Carlos, Madaria Pascual, Enrique de, Mallolas Masferrer, Josep, Mañá Rey, Juan, Marcas Vila, Álex, Marco Reverté, Francesc David, Marcos Maeso, M.ª Ángeles, Marrades Sicart, Ramón M.ª, Marruecos Sant, Lluís, Marrugat de la Iglesia, Jaume, Martín Sierra, Cristina, Martínez Díaz-Guerra, Guillermo, Martínez Martínez, José Antonio, Martínez Vea, Alberto, Martínez Yélamos, Sergio, Martínez Yoldi, Miguel J., Martorell Pons, Jaume, Mas Capó, Jordi, Mas Ordeig, Antoni, Masana Marín, Lluís, Masana Montejo, Guillem, Manuel Mascaró Galy, José, Matas Andreu, Lurdes, Maurel, Joan, Melero, Marcelo José, Melero Bermejo, Ignacio, Mellado González, Begoña, Mensa Pueyo, José, Mercé Klein, Jordi, Mestres Alomar, Gaspar, Milà Recasens, Monteserrat, Miquel Abbad, Carlos, Miralles Basseda, Ramón, Miralles Hernández, Manuel, Miró Meda, José M.ª, Mòdol Deltell, Josep M.ª, Molero Richard, Xavier, Molina Infante, Javier, Molins López-Rodó, Laureano, Mont Girbau, Lluís, Montoro Huguet, Miguel Ángel, Montserrat Canal, Josep M.ª, Morales-Olivas, Francisco José, Morán Chorro, Indalecio, Morata Ruiz, Laura, Morell Brotad, Ferran, Moreno Camacho, M.ª Asunción, Moreno Carriles, Rosa M.ª, Moreno Ramírez, David, Muñoz García, José Esteban, Muñoz García-Paredes, Patricia, Muñoz Gutiérrez, José, Muñoz Mateu, Montserrat, Muñoz Villegas, Álvaro, Muxí Pradas, M.ª África, Navarro Acebes, Xavier, Navasa Anadón, Miquel À., Nicolás Arfelis, José M.ª, Nogué Xarau, Santiago, Nolla Sañas, Joan, Miquel Nolla Solé, Joan, Norman, Francesca F., Obach Baurier, Victor, Obrador Vera, Gregorio Tomás, Oliva Dámaso, Elena, Olivé Marqués, Alejandro, Ordi Ros, José, Ortiz Arduan, Alberto, Ortiz de Lejarazu Leonardo, Raúl, Ortiz Rivera, Marta, Oteo Revuelta, José Antonio, Pablo Rabassó, Joan de, Palau Martínez, Francesc, Pallarés Giner, Román, Palou Rivera, Eduardo, Panés Díaz, Julià, Paré Bardera, Joan Carles, Parés Darnaculleta, Albert, Parrilla Paricio, Pascual, Pascal Capdevila, Mariona, Pascual Gómez, Eliseo, Pascual Gómez, Julio, Pedro-Botet Montoya, Juan, Pedro-Botet Montoya, M.ª Luisa, Pereira Saavedra, Arturo, Pérez Gisbert, Javier, Pérez Jurado, Luis Alberto, Pérez Sáenz, José Luis, Pérez Trallero, Emilio, Picado Vallés, César, Picado de Puig, Albert, Picó Alfonso, Antonio, Pigrau Serrallach, Carlos, Pinazo Delgado, M.ª Jesús, Pintado García, Vicente, Pintos Morell, Guillem, Piñeiro Ibáñez, Daniel José, Poch López de Briñas, Esteban, Pons Lladó, Guillem, Pons-Estel, Bernardo A., Pons-Estel, Guillermo J., Porcel Pérez, José Manuel, Portela Hernández, Margarita, Praga Terente, Manuel, Prat, Aleix, Puig Domingo, Manuel, Pujol Borrell, Ricardo, Pulido Mestre, Marta, Pumarola Suñé, Tomàs, Puras Mallagray, Enrique, Quintana Porras, Luis F., Quintero Carrión, Enrique, Rabinovich, Gabriel A., Rabionet Janssen, Raquel, Ramos Casals, Manuel, Real Arribas, Francisco X., Rego Castro, M.ª José, Reguart, Noemi, Regueiro González, José R., Reverter Calatayud, Jordi Lluís, Reverter Calatayud, Juan Carlos, Rey-Joly Barroso, Celestino, Reyes, José Miguel, Reynals de Blasis, Enrique, Riambau Alonso, Vicente, Ribera Casado, José Manuel, Ribera Santasusana, Josep M.ª, Ribes Rubió, Antonia, Rimola Castellá, Antoni, Río Bueno, Ana del, Robert Boter, Neus, Roca Antònio, Josep, Roca Torrent, Josep, Rodés Teixidor, Joan, Rodríguez Baño, Jesús, Rodríguez de Castro, Felipe, Rodríguez Panadero, Francisco, Rodríguez Pérez, José Carlos, Rodríguez Roisin, Roberto, Roig Minguell, Eulàlia, Rojas García, Ricardo, Romero Gómez, Manuel, Rovira Cañellas, Àlex, Rozman Borstnar, Ciril, Rozman Jurado, María, Ruiz Granell, Ricardo, Ruiz Manzano, Juan, Ruiz Moreno, Javier, Ruiz-Argüelles, Guillermo José, Sabaté Tenas, Manuel, Saiz Hinarejos, Albert, Salgado García, Emilio José, Salinas Vert, Isabel, San Miguel, Jesús F., Sánchez González, Marcelo, Sánchez Rodríguez, Ángel, Sánchez Tapias, José M.ª, Sanmartí Sala, Raimon, Santamaria Cano, Joan, Sanz Alonso, Miguel Ángel, Sanz Santillana, Guillermo F., Saperas Franch, Esteban, Segura Egea, Antonia, Segura Porta, Ferrán, Selva O’Callaghan, Albert, Serra Majem, Lluís, Sierra Gil, Jorge, Sierra Iserte, Alejandro de la, Sierra Romero, Gustavo Adolfo, Sitges Carreño, Marta, Solà Vergés, Elsa, Solana Lara, Rafael, Solans Laqué, Roser, Soldevila Melgarejo, M.ª Gloria, Sopena Galindo, Nieves, Soriano Viladomiu, Álex, Soy Muner, Dolors, Targarona Soler, Eduardo M.ª, Tejedor Jorge, Alberto, Tena Marsà, Xavier, de Teresa Galván, Eduardo, Tolosa Sarró, Eduardo, Tornero Molina, Jesús, Tornos Mas, Pilar, Torra Balcells, Roser, Torre Cisneros, Julián de la, Torregrosa Prats, José Vicente, Torres Hortal, Montserrat, Torres Martí, Antonio, Torres Ramírez, Armando, Torrico, Faustino, Trilla García, Antoni, Tuca Rodríguez, Albert, Tudela Hita, Pere, Urbano Ispizua, Álvaro, Urrutia de Diego, Agustín, Valdés Miyar, Manuel, Valls Lolla, M.ª Eugenia, Valls Solé, Josep, Vaquero Raya, Eva C., Vázquez Martínez, Clotilde, Vázquez Zaragoza, Miguel Ángel, Verea Hernando, Héctor, Vicente García, Vicente, Vidal Bermúdez, José E., Vidal-Puig, Antonio, Vieta Pascual, Eduardo, Vila Estapé, Jordi, Vilar, Eduardo, Vilardell Tarrés, Miguel, Vilella Morató, Anna, Villabona Artero, Carlos, Villamor Casas, Neus, Vinuesa Aumedes, Teresa, Viñolas, Nuria, Vives Corrons, Joan Lluís, Webb Youdale, Susan M., Xaubet Mir, Antonio, Yagüe Ribes, Jordi, and Zarranz Imirizaldu, Juan José

Published
2016
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48. Cáncer y Anti-TNF

Author

Tornero Molina, Jesús and Tornero Molina, Jesús

Published
2009

49. Usefulness of Rheumatology Consultancy in situ: Analysis of a Long-term Experience.

Author

Tornero-Molina J, Díez-Andrés ML, Alonso F, de la Llana-Calvo C, Luengo Rojo S, Casado Silvestre E, and Grado Sanz R

Abstract

Objective: To report the long-term experience of a rheumatologist consultant in situ (RCI) in a primary care centre (PCC)., Material and Methods: Observational retrospective study analysing the complete cohort of the patients seen by the RCI between 2013 and 2019. Rheumatology patients' clinical characteristics and course of care were collected to estimate the diagnoses that were most likely to be monitored by a primary care physician (PCP)., Results: A total of 876 consultations were attended; 205 were men (23.4%) and 671 women (76.6%). Most of the consultations (280, 33.2%) were diagnostic. On 167 occasions (19.8%) therapeutic issues were analysed; in 47 (5.6%) therapeutic infiltrations were performed. Chronic patient control was applied in 163 subjects (19.3%). A request for tests not available to the PCP was the reason for the consultation in 154 situations (18.3%). The profile most likely to continue being monitored in the PCC is the patient with osteoarthritis (OR=0.13, CI 95%: 0.02-0.67), soft tissue rheumatism (OR=0.006, 95%CI: 0.01-0.45) or cervical disc herniation (OR=0.13, 95%CI: 0.02-0.66). Less likely to be monitored by PCP after being seen by the RCI were subjects with rheumatoid arthritis (OR=0.03, 95%CI: 0.00-0.24), other inflammatory arthropathies (OR=0.36, 95%CI: 0.16-0.80) or with polymyalgia rheumatica (OR=0.19, 95%CI: 0.06-0.64), and those in need of chronic disease monitoring (OR=0.16, 95%CI: 0.07-0.34)., Conclusions: The RCI makes it easier for the PCP to monitor patients with osteoarthritis, soft tissue rheumatism and cervical disc pathology., (Copyright © 2021 Elsevier España, S.L.U. and Sociedad Española de Reumatología y Colegio Mexicano de Reumatología. All rights reserved.)

Published
2021
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50. Tele-Rheumatology During the COVID-19 Pandemic.

Author

Tornero-Molina J, Sánchez-Alonso F, Fernández-Prada M, Bris-Ochaita ML, Sifuentes-Giraldo A, and Vidal-Fuentes J

Abstract

Introduction: During the COVID-19 pandemic strategies to prevent transmission of the viral infection obliged our hospital to promote virtual consultations., Objetive: The objective of this study is to describe the results obtained with the previous strategy of transferring activity to teleconsultation during the period of maximum impact of the pandemic., Material and Methods: Between 16/03 and 10/05/2020 all successive consultations in our unit were performed in virtual rheumatology teleconference (RTC) format. The socio-demographic, geo-functional and clinical characteristics of all patients were collected; a numeric verbal scale (NVS) (where 0=very dissatisfied to 10=fully satisfied) was applied to assess the degree of satisfaction of the doctor/patient with the RTC., Results: 469 TC were included. Most patients seen by RTC were women, mean age: 60,83 years. Only 16% had university education. The mean distance travelled for face-to face consultation is 33 Km with a mean total time of 2hours. Most individuals were diagnosed with osteoarthritis/soft tissue rheumatic diseases and/or osteoporosis; 21% had rheumatoid arthritis. The mean length of the TC was 9.64minutes. We find more patient satisfaction with the TC when their level of education is higher (OR=4.12); doctor satisfaction was higher when the individual was better able to manage the Internet (OR=3.01)., Conclusion: It is possible to transfer rheumatological care activity to TC with a considerable degree of satisfaction for both the patient and the doctor., (Copyright © 2020 Elsevier España, S.L.U. and Sociedad Española de Reumatología y Colegio Mexicano de Reumatología. All rights reserved.)

Published
2020
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