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1. Low-density lipoprotein particle profiles compared with standard lipids measurements in the association with asymptomatic intracranial artery stenosis

Author

Vu, Thien, Yano, Yuichiro, Pham, Huy Kien Tai, Mondal, Rajib, Ohashi, Mizuki, Kitaoka, Kaori, Moniruzzaman, Mohammad, Torii, Sayuki, Shiino, Akihiko, Tsuji, Atsushi, Hisamatsu, Takashi, Okamura, Tomonori, Kondo, Keiko, Kadota, Aya, Watanabe, Yoshiyuki, Nozaki, Kazuhiko, Ueshima, Hirotsugu, and Miura, Katsuyuki

Published
2024
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7. Association of Anthropometric and CT-Based Obesity Indices with Subclinical Atherosclerosis

Author

Higo, Yosuke, primary, Hisamatsu, Takashi, additional, Nakagawa, Yoshihisa, additional, Sawayama, Yuichi, additional, Yano, Yuichiro, additional, Kadota, Aya, additional, Fujiyoshi, Akira, additional, Kadowaki, Sayaka, additional, Torii, Sayuki, additional, Kondo, Keiko, additional, Watanabe, Yoshiyuki, additional, Ueshima, Hirotsugu, additional, and Miura, Katsuyuki, additional

Published
2024
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10. Relationship between Serum Irisin Levels and MRI-Measured Cerebral Small Vessel Disease in Japanese Men

Author

Moniruzzaman, Mohammad, primary, Kadota, Aya, additional, Hisamatsu, Takashi, additional, Segawa, Hiroyoshi, additional, Kondo, Keiko, additional, Torii, Sayuki, additional, Miyagawa, Naoko, additional, Fujiyoshi, Akira, additional, Yano, Yuichiro, additional, Watanabe, Yoshiyuki, additional, Shiino, Akihiko, additional, Nozaki, Kazuhiko, additional, Ueshima, Hirotsugu, additional, and Miura, Katsuyuki, additional

Published
2023
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11. Lifetime cigarette smoking is associated with abdominal obesity in a community-based sample of Japanese men: The Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA)

Author

Fujiyoshi, Akira, Miura, Katsuyuki, Kadowaki, Sayaka, Azuma, Koichiro, Tanaka, Sachiko, Hisamatsu, Takashi, Arima, Hisatomi, Kadota, Aya, Miyagawa, Naoko, Takashima, Naoyuki, Ohkubo, Takayoshi, Saitoh, Yoshino, Torii, Sayuki, Miyazawa, Itsuko, Maegawa, Hiroshi, Murata, Kiyoshi, and Ueshima, Hirotsugu

Published
2016
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12. Associations of serum LDL particle concentration with carotid intima-media thickness and coronary artery calcification

Author

Ueshima, Hirotsugu, Miura, Katsuyuki, Horie, Minoru, Nakano, Yasutaka, Yamamoto, Takashi, Ogawa, Emiko, Maegawa, Hiroshi, Miyazawa, Itsuko, Murata, Kiyoshi, Mitsunami, Kenichi, Nozaki, Kazuhiko, Shiino, Akihiko, Araki, Isao, Tsuru, Teruhiko, Toyama, Ikuo, Ogita, Hisakazu, Kurita, Souichi, Maeda, Toshinaga, Miyamatsu, Naomi, Kita, Toru, Kimura, Takeshi, Nishio, Yoshihiko, Nakamura, Yasuyuki, Okamura, Tomonori, Sekikawa, Akira, Barinas-Mitchell, Emma J.M., Edmundowicz, Daniel, Ohkubo, Takayoshi, Hozawa, Atsushi, Okuda, Nagako, Higashiyama, Aya, Nagasawa, Shinya, Kita, Yoshikuni, Murakami, Yoshitaka, Kadota, Aya, Fujiyoshi, Akira, Takashima, Naoyuki, Kadowaki, Takashi, Kadowaki, Sayaka, Abbott, Robert D., Ohno, Seiko, Arima, Hisatomi, Hisamatsu, Takashi, Miyagawa, Naoko, Torii, Sayuki, Saito, Yoshino, Zaid, Maryam, Suzuki, Sentaro, and Ito, Takahiro

Published
2016
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15. Abstract MP02: Gut Microbiome Alteration and Structural Brain Features Among Healthy Japanese Men

Author

Ahmed, Sabrina, primary, Yano, Yuichiro, additional, Hexun, Zhang, additional, Okami, Yukiko, additional, Mohd Azahar, Nazar Mohd Zabadi, additional, Kondo, Keiko, additional, Arima, Hisatomi, additional, Torii, Sayuki, additional, Moniruzzaman, Mohammad, additional, Kadota, Aya, additional, Andoh, Akira, additional, Shiino, Akihiko, additional, Nozaki, Kazuhiko, additional, Ueshima, Hirotsugu, additional, and Miura, Katsuyuki, additional

Published
2023
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16. Abstract P671: Association Between Renal Function and Silent Cerebrovascular Disease in Japanese Men

Author

Miyagawa, Naoko, primary, Takashima, Naoyuki, additional, Kadota, Aya, additional, Fujiyoshi, Akira, additional, Torii, Sayuki, additional, Segawa, Hiroyoshi, additional, Miyazawa, Itsuko, additional, Kume, Shinji, additional, Kondo, Keiko, additional, Hisamatsu, Takashi, additional, Yano, Yuichiro, additional, Shiino, Akihiko, additional, Nozaki, Kazuhiko, additional, Ueshima, Hirotsugu, additional, and Miura, Katsuyuki, additional

Published
2023
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17. PS-BPP01-4: THE RELATIONSHIP BETWEEN SERUM PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 CONCENTRATION AND THE PREVALENCE OF CORONARY ARTERY CALCIUM

Author

Kunimura, Ayako, primary, Miura, Katsuyuki, additional, Segawa, Hiroyoshi, additional, Torii, Sayuki, additional, Kondo, Keiko, additional, Hisamatsu, Takashi, additional, Yano, Yuichiro, additional, Kadota, Aya, additional, Fujiyoshi, Akira, additional, Nakagawa, Yoshihisa, additional, Okamura, Tomonori, additional, and Ueshima, Hirotsugu, additional

Published
2023
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18. S-57-5: GUT MICROBIOME DIVERSITY AND BRAIN VOLUME AMONG GENERAL JAPANESE MEN

Author

Ahmed, Sabrina, primary, Yano, Yuichiro, additional, Hexun, Zhang, additional, Okami, Yukiko, additional, Azahar, Nazar Mohd, additional, Kondo, Keiko, additional, Arima, Hisatomi, additional, Torii, Sayuki, additional, Moniruzzaman, Mohammad, additional, Kadota, Aya, additional, Andoh, Akira, additional, Shiino, Akihiko, additional, Ueshima, Hirotsugu, additional, and Miura, Katsuyuki, additional

Published
2023
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19. PS-BPP01-2: ASSOCIATIONS OF ARTERIAL STIFFNESS AND ATHEROSCLEROTIC BURDEN WITH BRAIN STRUCTURAL CHANGES AMONG JAPANESE MEN

Author

Azahar, Nazar Mohd, primary, Yano, Yuichiro, additional, Kadota, Aya, additional, Shiino, Akihiko, additional, Miyagawa, Naoko, additional, Kondo, Keiko, additional, Moniruzzaman, Mohammad, additional, Torii, Sayuki, additional, Segawa, Hiroyoshi, additional, Hisamatsu, Takashi, additional, Fujiyoshi, Akira, additional, Nozaki, Kazuhiko, additional, Tooyama, Ikuo, additional, Ueshima, Hirotsugu, additional, and Miura, Katsuyuki, additional

Published
2023
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20. PS-BPP01-3: DIFFERENTIAL ASSOCIATION OF CIRCULATING PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 WITH THE SUBCLINICAL CEREBRAL SMALL VESSEL DISEASE AND INTRACRANIAL ARTERY STENOSIS

Author

Kunimura, Ayako, primary, Yano, Yuichiro, additional, Torii, Sayuki, additional, Kondo, Keiko, additional, Hisamatsu, Takashi, additional, Kadota, Aya, additional, Fujiyoshi, Akira, additional, Okamura, Tomonori, additional, Watanabe, Yoshiyuki, additional, Shiino, Akihiko, additional, Nozaki, Kazuhiko, additional, Ueshima, Hirotsugu, additional, and Miura, Katsuyuki, additional

Published
2023
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21. PS-C23-2: GUT MICROBIOTA AND SUBCLINICAL CORONARY ARTERY CALCIFICATION IN A GENERAL POPULATION OF JAPANESE MEN

Author

Okami, Yukiko, primary, Arima, Hisatomi, additional, Kondo, Keiko, additional, Hexun, Zhang, additional, Yano, Yuichiro, additional, Kadota, Aya, additional, Torii, Sayuki, additional, Hisamatsu, Takashi, additional, Fujiyoshi, Akira, additional, Kadowaki, Sayaka, additional, Watanabe, Yoshiyuki, additional, Ando, Akira, additional, Nakagawa, Yoshihisa, additional, Ueshima, Hirotsugu, additional, and Miura, Katsuyuki, additional

Published
2023
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23. Relationship between Kidney Function and Subclinical Atherosclerosis Progression Evaluated by Coronary Artery Calcification

Author

Ganbaatar, Namuun, primary, Kadota, Aya, additional, Hisamatsu, Takashi, additional, Araki, Shin-Ichi, additional, Kume, Shinji, additional, Fujiyoshi, Akira, additional, Kadowaki, Sayaka, additional, Torii, Sayuki, additional, Kondo, Keiko, additional, Segawa, Hiroyoshi, additional, Salman, Ebtehal, additional, Miyazawa, Itsuko, additional, Yamamoto, Takashi, additional, Nakagawa, Yoshihisa, additional, Maegawa, Hiroshi, additional, Miura, Katsuyuki, additional, and Ueshima, Hirotsugu, additional

Published
2022
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24. Association of Alcohol Consumption With Fat Deposition in a Community-Based Sample of Japanese Men: The Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA)

Author

Sumi, Masaki, Hisamatsu, Takashi, Fujiyoshi , Akira, Kadota, Aya, Miyagawa, Naoko, Kondo, Keiko, Kadowaki, Sayaka, Suzuki , Sentaro, Torii, Sayuki, Zaid Maryam, Sato, Atsushi, Arima, Hisatomi, Terada, Tomohiro, Miura, Katsuyuki, Ueshima , Hirotsugu, Horie Minoru, Nakano Yasutaka, Yamamoto Takashi, Hayashi Hideki, Ogawa Emiko, Maegawa Hiroshi, Miyazawa Itsuko, Murata Kiyoshi, Mitsunami Kenichi, Nozaki Kazuhiko, Tooyama Ikuo, Shiino Akihiko, Tsuru Teruhiko, Ogita Hisakazu, Shimizu Akio, Miyamatsu Naomi, Kita Toru, Kimura Takeshi, Nishio Yoshihiko, Nakamura Yasuyuki, Okamura Tomonori, Sekikawa Akira, Barinas-Mitchell Emma J. M., Edmundowicz Daniel, Ohkubo Takayoshi, Hozawa Atsushi, Murakami Yoshitaka, Okuda Nagako, Arima Hisatomi, Kita Yoshikuni, Hisamatsu Takashi, Higashiyama Aya, Nagasawa Shinya, Azuma Koichiro, Yanagita Masahiko, Abbott Robert D., Kadota Aya, Ohno Seiko, Fujiyoshi Akira, Takashima Naoyuki, Kadowaki Takashi, Kadowaki Sayaka, Miyagawa Naoko, Kondo Keiko, Torii Sayuki, Saito Yoshino, Suzuki Sentaro, Ito Takahiro, Satoh Atsushi, and Yamazoe Masahiro

Subjects
Adult, Male, medicine.medical_specialty, Alcohol Drinking, Epidemiology, alcohol consumption, Population, Adipose tissue, 030209 endocrinology & metabolism, Intra-Abdominal Fat, 03 medical and health sciences, 0302 clinical medicine, Japan, Internal medicine, medicine, Humans, 030212 general & internal medicine, visceral adipose tissue, Adverse effect, education, Nutrition, Aged, lcsh:R5-920, education.field_of_study, Anthropometry, business.industry, anthropometric obesity indice, Confounding, nutritional and metabolic diseases, General Medicine, Middle Aged, medicine.disease, fat deposition, Obesity, Subcutaneous Fat, Abdominal, Epidemiologic Studies, Cross-Sectional Studies, Population Surveillance, Original Article, lcsh:Medicine (General), Tomography, X-Ray Computed, business, Body mass index
Abstract

Background: Excessive alcohol intake has been shown to be associated with cardiovascular disease via metabolic pathways. However, the relationship between alcohol intake and obesity has not been fully elucidated. We aimed to examine the association of alcohol consumption with fat deposition and anthropometric measures. Methods: From 2006–2008, we conducted a cross-sectional study in a population-based sample of Japanese men aged 40 through 79 years. Areas of abdominal visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) were calculated using computed tomography imaging. Based on a questionnaire, we classified participants into five groups according to weekly alcohol consumption, excluding former drinkers: non-drinkers (0 g/week), 0.1–160.9, 161–321.9, 322–482.9, and ≥483 g/week. Multivariable linear regression was used to estimate adjusted means of obesity indices for each group. Results: We analyzed 998 men (mean age and body mass index [BMI], 63.8 years and 23.6 kg/m2, respectively). Higher weekly alcohol consumption was strongly and significantly associated with higher abdominal VAT area, percentage of VAT, and VAT-to-SAT ratio (all P for trend

Published
2019
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26. Association between proprotein convertase subtilisin/kexin type 9 and subclinical cerebrovascular disease in the community.

Author

Kunimura, Ayako, Yano, Yuichiro, Hisamatsu, Takashi, Torii, Sayuki, Kondo, Keiko, Kadota, Aya, Fujiyoshi, Akira, Okamura, Tomonori, Watanabe, Yoshiyuki, Shiino, Akihiko, Nozaki, Kazuhiko, Ueshima, Hirotsugu, and Miura, Katsuyuki

Subjects
CEREBRAL small vessel diseases, CEREBROVASCULAR disease, SUBTILISINS, LDL cholesterol, COMMUNITIES, LACUNAR stroke, ARTERIAL stenosis
Abstract

Background and purpose: Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a new target for reducing low‐density lipoprotein cholesterol and incident cardiovascular disease, including stroke. However, the clinical relevance of circulating PCSK9 levels has been poorly elucidated in the general population, particularly in association with subclinical cerebrovascular disease including cerebral small vessel disease (CSVD) and intracranial artery stenosis (ICAS). Methods: In community‐dwelling Japanese men (n = 526) aged 46–82 years without a history of cardiovascular disease, the associations of serum PCSK9 levels with the prevalence of CSVD and ICAS were assessed using magnetic resonance imaging. CSVD included lacunar infarction, deep and subcortical white matter hyperintensity, periventricular hyperintensity and cerebral microbleeds. Results: The median (interquartile range) age at baseline and serum PCSK9 levels were 69 (63–74) years and 240 (205–291) ng/ml, respectively. After adjusting for traditional cardiovascular risk factors including low‐density lipoprotein cholesterol, multivariable Poisson regression with robust error variance revealed a significant association between PCSK9 levels (per 1 SD) and ICAS (relative risks 1.18, 95% confidence interval 1.02–1.37). Multivariable ordinal logistic regression for ICAS, with stenosis graded as mild (<50%) or moderate–severe (≥50%), revealed a similar association (common odds ratio 1.31, 95% confidence interval 1.04–1.64). However, no significant association was observed between serum PCSK9 levels and CSVD. Conclusions: Higher circulating PCSK9 levels were independently associated with an ICAS prevalence but not with CSVD prevalence. The quantification of circulating PCSK9 levels may help to identify individuals at high risk for cerebrovascular disease in the general population. [ABSTRACT FROM AUTHOR]

Published
2023
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27. Relationship of Four Blood Pressure Indexes to Subclinical Cerebrovascular Diseases Assessed by Brain MRI in General Japanese Men

Author

Salman, Ebtehal, primary, Kadota, Aya, additional, Hisamatsu, Takashi, additional, Segawa, Hiroyoshi, additional, Torii, Sayuki, additional, Fujiyoshi, Akira, additional, Kondo, Keiko, additional, Watanabe, Yoshiyuki, additional, Arima, Hisatomi, additional, Shiino, Akihiko, additional, Nozaki, Kazuhiko, additional, Ueshima, Hirotsugu, additional, and Miura, Katsuyuki, additional

Published
2022
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28. Predictors of lower limb fractures in general Japanese: NIPPON DATA90

Author

SAITO, Yoshino, MIURA, Katsuyuki, ARIMA, Hisatomi, HAYAKAWA, Takehito, TAKASHIMA, Naoyuki, KITA, Yoshikuni, OKUDA, Nagako, FUJIYOSHI, Akira, IWAHORI, Toshiyuki, MIYAGAWA, Naoko, KONDO, Keiko, TORII, Sayuki, KADOTA, Aya, OHKUBO, Takayoshi, OKAYAMA, Akira, OKAMURA, Tomonori, UESHIMA, Hirotsugu, and NIPPON DATA90 Research Group

Subjects
Male, Asia, Databases, Factual, Epidemiology, Physiology, Science, Body Mass Index, Geographical Locations, Fractures, Bone, Japan, Risk Factors, Medicine and Health Sciences, Humans, Public and Occupational Health, Prospective Studies, Femur, Musculoskeletal System, Skeleton, Aged, Proportional Hazards Models, Nutrition, Multidisciplinary, Incidence, Traumatic Injury Risk Factors, Body Weight, Age Factors, Biology and Life Sciences, Middle Aged, Nutrition Surveys, Diet, Lower Extremity, Physiological Parameters, Food, Body Limbs, Medical Risk Factors, People and Places, Medicine, Female, Anatomy, Femoral Fractures, Research Article
Abstract

Objective:This study aimed to investigate the incidence rates and predictors of lower limb fractures in a general Japanese population., Methods:NIPPON DATA is a nationwide, long-term, prospective cohort study of individuals who participated in the National Cardiovascular Survey Japan and the National Nutrition Survey in 1990. Overall, 3,134 individuals (1,827 women, 1,307 men) who participated in follow-up assessments in 1995, 2000, and/or 2006 were included in the present analysis. The outcomes of this study were lower limb fractures (including proximal femur fractures)., Results:The mean age at baseline was 63.8 years in women and 63.1 years in men. The average body mass index (BMI) was 23.3 kg/m2 in women and 22.9 kg/m2 in men. During a mean follow-up of 12.1 years, 271 total lower limb fractures were observed. In women, older age, lower BMI, and less intake of vegetables were associated with increased risks of proximal femur fractures. With regard to the outcome of total lower limb fractures, less intake of vegetables and regular exercise were significant predictors in women. Calcium intake was not significantly associated with proximal femur or total lower limb fractures. There were no significant predictors of proximal femur or total lower limb fractures in men, except for age., Conclusions:Aging was a significant risk factor for proximal femur and total lower limb fractures in both men and women. With regard to modifiable risk factors, low BMI and low intake of vegetables were associated with increased risks of proximal femur and/or total lower limb fractures in the general population of Japanese women.

Published
2021

31. Association of self-measured home, ambulatory, and strictly measured office blood pressure and their variability with intracranial arterial stenosis

Author

Hisamatsu, Takashi, primary, Ohkubo, Takayoshi, additional, Hozawa, Atsushi, additional, Fujiyoshi, Akira, additional, Torii, Sayuki, additional, Segawa, Hiroyoshi, additional, Kondo, Keiko, additional, Kadota, Aya, additional, Takashima, Naoyuki, additional, Shitara, Satoshi, additional, Arima, Hisatomi, additional, Nakagawa, Yoshihisa, additional, Watanabe, Yoshiyuki, additional, Shiino, Akihiko, additional, Nozaki, Kazuhiko, additional, Ueshima, Hirotsugu, additional, and Miura, Katsuyuki, additional

Published
2021
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32. Differential Association of Serum n-3 Polyunsaturated Fatty Acids with Various Cerebrovascular Lesions in Japanese Men.

Author

Kondo, Keiko, Arima, Hisatomi, Fujiyoshi, Akira, Sekikawa, Akira, Kadota, Aya, Hisamatsu, Takashi, Torii, Sayuki, Shiino, Akihiko, Morino, Katsutaro, Miyagawa, Naoko, Segawa, Hiroyoshi, Watanabe, Yoshiyuki, Maegawa, Hiroshi, Nozaki, Kazuhiko, Miura, Katsuyuki, and Ueshima, Hirotsugu

Subjects
OMEGA-3 fatty acids, UNSATURATED fatty acids, LACUNAR stroke, JAPANESE people, MAGNETIC resonance imaging, EICOSAPENTAENOIC acid
Abstract

Background: An association between a high intake of marine-derived n-3 polyunsaturated fatty acids (n-3 PUFAs) with a lower risk of coronary heart disease was previously reported. However, the association between n-3 PUFAs and cerebrovascular lesions remains unclear. We evaluated this association in a general-population-based sample of Japanese men. Methods: Participants were community-dwelling men (40–79 years old) living in Kusatsu City, Shiga, Japan. Serum concentrations of n-3 PUFAs, defined as the sum of eicosapentaenoic and docosahexaenoic acids, were measured via gas-liquid chromatography between 2006 and 2008. Magnetic resonance imaging was used to assess cerebrovascular lesions (including intracerebral large-artery stenosis, lacunar infarction, and microbleeds) and white matter lesions between 2012 and 2015. Logistic regression adjusting for conventional cardiovascular risk factors was used to estimate the odds ratio of prevalent cerebrovascular lesions per 1 standard deviation higher serum concentration of n-3 PUFAs. Results: Of a total of 739 men, the numbers (crude prevalence in %) of prevalent cerebral large-artery stenoses, lacunar infarctions, microbleeds, and white matter lesions were 222 (30.0), 162 (21.9), 103 (13.9), and 164 (22.2), respectively. A 1 standard deviation higher concentration of n-3 PUFAs (30.5 μmol/L) was independently associated with lower odds of cerebral large-artery stenosis (multivariable-adjusted odds ratio, 0.80; 95% confidential interval, 0.67–0.97). There were no significant associations of n-3 PUFAs with the other types of lesions. Conclusions: n-3 PUFAs may have protective effects against large-artery stenosis, but not small vessel lesions, in the brain. [ABSTRACT FROM AUTHOR]

Published
2022
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34. Differences between home blood pressure and strictly measured office blood pressure and their determinants in Japanese men

Author

KADOWAKI, Sayaka, KADOWAKI, Takashi, HOZAWA, Atsushi, FUJIYOSHI, Akira, HISAMATSU, Takashi, SATOH, Atsushi, ARIMA, Hisatomi, Tanaka-Mizuno, Sachiko, TORII, Sayuki, KONDO, Keiko, KADOTA, Aya, Masaki, Kamal, OKAMURA, Tomonori, OHKUBO, Takayoshi, MIURA, Katsuyuki, UESHIMA, Hirotsugu, and Shiga, Epidemiological Study of Subclinical Atherosclerosis (SESSA) Research Group

Subjects
Male, medicine.medical_specialty, Population level, Physiology, Office blood pressure, Population, Blood Pressure, 030204 cardiovascular system & hematology, 03 medical and health sciences, 0302 clinical medicine, Japan, Internal medicine, Linear regression, Internal Medicine, Medicine, Humans, 030212 general & internal medicine, education, Rest time, Antihypertensive Agents, education.field_of_study, business.industry, Home blood pressure, Blood Pressure Determination, General population, Blood Pressure Monitoring, Ambulatory, Individual level, Blood pressure, Hypertension, Cardiology and Cardiovascular Medicine, business
Abstract

Conventional office blood pressure (OBP) and home blood pressure (HBP) measurements are often inconsistent. The purpose of this research was (1) to test whether strictly measured OBP values with sufficient rest time before measurement (st-OBP) is comparable to HBP at the population level and (2) to ascertain whether there are particular determinants for the difference between HBP and st-OBP at the individual level. Data from a population-based group of 1056 men aged 40–79 years were analyzed. After a five-min rest, st-OBP was measured twice. HBP was measured after a 2-min rest every morning for seven consecutive days. To determine factors related to ΔSBP (HBP minus st-OBP measurements), multiple linear regression analyses and analyses of covariance were performed. While st-OBP and HBP were comparable (136.5 vs. 137.2 mmHg) at the population level, ΔSBP varied with a standard deviation of 13.5 mmHg. Smoking was associated with a larger ΔSBP regardless of antihypertensive usage, and BMI was associated with a larger ΔSBP in participants using antihypertensive drugs. The adjusted mean ΔSBP in the highest BMI tertile category was 4.6 mmHg in participants taking antihypertensive drugs. st-OBP and HBP measurements were comparable at the population level, although the distribution of ΔSBP was considerably broad. Smokers and obese men taking antihypertensive drugs had higher HBP than st-OBP, indicating that their blood pressure levels are at risk of being underestimated. Therefore, this group would benefit from the addition of HBP measurements.

Published
2020

35. Differences Between Coronary Artery Calcification and Aortic Artery Calcification in Relation to Cardiovascular Disease Risk Factors in Japanese Men

Author

Kimani Cecilia, Kadota Aya, Miura Katsuyuki, Fujiyoshi Akira, Zaid Maryam, Kadowaki Sayaka, Hisamatsu Takashi, Arima Hisatomi, Horie Minoru, Ueshima Hirotsugu, Yamamoto Takashi, Maegawa Hiroshi, Murata Kiyoshi, Nozaki Kazuhiko, Shiino Akihiko, Toyama Ikuo, Tsuru Teruhiko, Ogita Hisakazu, Takashima Naoyuki, Kadowaki Takashi, Miyamatsu Naomi, Miyagawa Naoko, Torii Sayuki, Hayashi Hideki, Nakano Yasutaka, Ogawa Emiko, Miyazawa Itsuko, Shimizu Akio, Abbott Robert D., Kondo Keiko, Suzuki Sentaro, Ito Takahiro, Andoh Akira, Kunimura Ayako, Nishio Yoshihiko, Mitsunami Kenichi, Kita Toru, Kimura Takeshi, Tabara Yasuharu, Nakamura Yasuyuki, Okamura Tomonori, Sekikawa Akira, Barinas-Mitchell Emma J. M., Ohkubo Takayoshi, Kita Yoshikuni, Murakami Yoshitaka, Hozawa Atsushi, Okuda Nagako, Higashiyama Aya, Ohno Seiko, Nagasawa Shinya, Yamazo Masahiro, Saito Yoshino, Edmundowicz Daniel, Satoh Atsushi, Azuma Koichiro, Yanagita Masahiko, Sawamura Tatsuya, and Igase Michiya

Subjects
Adult, Male, medicine.medical_specialty, Aortic Diseases, Renal function, Blood lipids, Coronary Artery Disease, 030204 cardiovascular system & hematology, Coronary artery, Logistic regression, Calcification, 03 medical and health sciences, 0302 clinical medicine, Japan, Internal medicine, Internal Medicine, Humans, Medicine, cardiovascular diseases, Vascular Calcification, Generalized estimating equation, Aorta, Aged, 2. Zero hunger, business.industry, Incidence, Biochemistry (medical), nutritional and metabolic diseases, Odds ratio, Middle Aged, Prognosis, medicine.disease, Coronary Vessels, Aortic artery, Cardiovascular diseases, Risk factors, 3. Good health, Blood pressure, Cardiology, Original Article, Cardiology and Cardiovascular Medicine, business, Body mass index, 030217 neurology & neurosurgery, Follow-Up Studies
Abstract

Aims: Calcification in the coronary and aortic arteries has been linked to cardiovascular morbidity and mortality. The pathophysiological influence of aortic artery calcification (AAC) differs from that of coronary artery calcification (CAC). We aimed to compare the relationships between CAC and AAC and cardiovascular disease (CVD) risk factors. Methods: We examined a random sample of 1035 Japanese men aged 40–79 years. CAC and AAC were measured by computed tomography and scored according to the Agatston method. Using a logistic regression, we calculated the odds ratio (OR) as being in the highest quintile (Q5) of the calcification score compared to the lower quintiles (Q1–Q4) per 1 standard deviation higher CVD risk factor. Models were simultaneously adjusted for age, body mass index (BMI), systolic blood pressure, smoking (pack-year), alcohol intake, hemoglobin A1c, uric acid, estimated glomerular filtration rate (eGFR), serum lipids, and C-reactive protein. Differences in ORs were investigated using a generalized estimating equation. We performed a multiple linear regression using log-transformed CAC and AAC values as dependent variables. Results: CAC and AAC were independently associated with age (OR, 95% CI: 2.30 [1.77–2.98] for CAC and 3.48 [2.57–4.73] for AAC), p for difference < 0.001), systolic blood pressure (1.29 [1.08–1.53] and 1.28 [1.07–1.54], p for difference = 0.270), and smoking (1.22, [1.04–1.43] and 1.34 [1.13–1.58]) p for difference = 0.071). Alcohol correlated with AAC only (1.17 [0.97–1.41] for CAC and 1.42 [1.16–1.73] for AAC, p for difference = 0.020). Conclusions: CAC and AAC were associated with similar CVD risk factors. The strength of association slightly differed between CAC and AAC.

Published
2019

36. Abstract P096: Association Of Accurately Measured Office, Self-measured Home, And Ambulatory Blood Pressure And Their Variability With Intracranial Arterial Stenosis

Author

Hisamatsu, Takashi, primary, Ohkubo, Takayoshi, additional, Fujiyoshi, Akira, additional, Torii, Sayuki, additional, Segawa, Hiroyoshi, additional, Kondo, Keiko, additional, Kadota, Aya, additional, Takashima, Naoyuki, additional, Shitara, Satoshi, additional, Arima, Hisatomi, additional, Nakagawa, Yoshihisa, additional, Watanabe, Yoshiyuki, additional, Shiino, Akihiko, additional, Nozaki, Kazuhiko, additional, Ueshima, Hirotsugu, additional, and Miura, Katsuyuki, additional

Published
2021
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37. Alcohol drinking and brain morphometry in apparently healthy community-dwelling Japanese men

Author

Syaifullah, Ali Haidar, primary, Shiino, Akihiko, additional, Fujiyoshi, Akira, additional, Kadota, Aya, additional, Kondo, Keiko, additional, Ito, Takahiro, additional, Segawa, Hiroyoshi, additional, Moniruzzaman, Mohammad, additional, Waki, Takashi, additional, Miyagawa, Naoko, additional, Tooyama, Ikuo, additional, Ueshima, Hirotsugu, additional, Miura, Katsuyuki, additional, Horie, Minoru, additional, Nakagawa, Yoshihisa, additional, Yamamoto, Takashi, additional, Nakano, Yasutaka, additional, Ogawa, Emiko, additional, Maegawa, Hiroshi, additional, Morino, Katsutaro, additional, Miyazawa, Itsuko, additional, Watanabe, Yoshiyuki, additional, Nozaki, Kazuhiko, additional, Andoh, Akira, additional, Tsuru, Teruhiko, additional, Ogita, Hisakazu, additional, Miyamatsu, Naomi, additional, Nakamura, Yasuyuki, additional, Torii, Sayuki, additional, Kadowaki, Takashi, additional, Kadowaki, Sayaka, additional, Suzuki, Sentaro, additional, Kunimura, Ayako, additional, Higashiyama, Aya, additional, Okamura, Tomonori, additional, Azuma, Koichiro, additional, Sawamura, Tatsuya, additional, Igase, Michiya, additional, Tabara, Yasuharu, additional, Sekikawa, Akira, additional, Barinas-Mitchell, Emma J.M., additional, Edmundowicz, Daniel, additional, Ohkubo, Takayoshi, additional, Hozawa, Atsushi, additional, Murakami, Yoshitaka, additional, Okuda, Nagako, additional, Arima, Hisatomi, additional, Satoh, Atsushi, additional, Kita, Yoshikuni, additional, Hisamatsu, Takashi, additional, Yanagita, Masahiko, additional, Abbott, Robert D., additional, Ohno, Seiko, additional, Takashima, Naoyuki, additional, Zaid, Maryam, additional, and Saito, Yoshino, additional

Published
2021
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38. Proteinuria and Reduced Estimated Glomerular Filtration Rate are Independently Associated With Lower Cognitive Abilities in Apparently Healthy Community-Dwelling Elderly Men in Japan: A Cross-sectional Study

Author

Fujiyoshi, Akira, primary, Miura, Katsuyuki, additional, Ohkubo, Takayoshi, additional, Miyagawa, Naoko, additional, Saito, Yoshino, additional, Miyazawa, Itsuko, additional, Shiino, Akihiko, additional, Kadota, Aya, additional, Kadowaki, Sayaka, additional, Hisamatsu, Takashi, additional, Torii, Sayuki, additional, Takashima, Naoyuki, additional, Tooyama, Ikuo, additional, and Ueshima, Hirotsugu, additional

Published
2020
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39. Proteinuria and Reduced Estimated Glomerular Filtration Rate are Independently Associated With Lower Cognitive Abilities in Apparently Healthy Community-Dwelling Elderly Men in Japan: A Cross-sectional Study

Author

Fujiyoshi Akira, Miura Katsuyuki, Ohkubo Takayoshi, Miyagawa Naoko, Saito Yoshino, Miyazawa Itsuko, Shiino Akihiko, Kadota Aya, Kadowaki Sayaka, Hisamatsu , Takashi, Torii , Sayuki, Takashima, Naoyuki, Tooyama, Ikuo, Ueshima, Hirotsugu, Fujiyoshi Akira, Miura Katsuyuki, Ohkubo Takayoshi, Miyagawa Naoko, Saito Yoshino, Miyazawa Itsuko, Shiino Akihiko, Kadota Aya, Kadowaki Sayaka, Hisamatsu , Takashi, Torii , Sayuki, Takashima, Naoyuki, Tooyama, Ikuo, and Ueshima, Hirotsugu

Published
2020

40. Predictors of lower limb fractures in general Japanese: NIPPON DATA90.

Author

Saito, Yoshino, Miura, Katsuyuki, Arima, Hisatomi, Hayakawa, Takehito, Takashima, Naoyuki, Kita, Yoshikuni, Okuda, Nagako, Fujiyoshi, Akira, Iwahori, Toshiyuki, Miyagawa, Naoko, Kondo, Keiko, Torii, Sayuki, Kadota, Aya, Ohkubo, Takayoshi, Okayama, Akira, Okamura, Tomonori, and Ueshima, Hirotsugu

Subjects
HIP fractures, JAPANESE people, JAPANESE women, BODY mass index, NUTRITION surveys
Abstract

Objective: This study aimed to investigate the incidence rates and predictors of lower limb fractures in a general Japanese population. Methods: NIPPON DATA is a nationwide, long-term, prospective cohort study of individuals who participated in the National Cardiovascular Survey Japan and the National Nutrition Survey in 1990. Overall, 3,134 individuals (1,827 women, 1,307 men) who participated in follow-up assessments in 1995, 2000, and/or 2006 were included in the present analysis. The outcomes of this study were lower limb fractures (including proximal femur fractures). Results: The mean age at baseline was 63.8 years in women and 63.1 years in men. The average body mass index (BMI) was 23.3 kg/m2 in women and 22.9 kg/m2 in men. During a mean follow-up of 12.1 years, 271 total lower limb fractures were observed. In women, older age, lower BMI, and less intake of vegetables were associated with increased risks of proximal femur fractures. With regard to the outcome of total lower limb fractures, less intake of vegetables and regular exercise were significant predictors in women. Calcium intake was not significantly associated with proximal femur or total lower limb fractures. There were no significant predictors of proximal femur or total lower limb fractures in men, except for age. Conclusions: Aging was a significant risk factor for proximal femur and total lower limb fractures in both men and women. With regard to modifiable risk factors, low BMI and low intake of vegetables were associated with increased risks of proximal femur and/or total lower limb fractures in the general population of Japanese women. [ABSTRACT FROM AUTHOR]

Published
2022
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41. Abstract P009: Association Between Intracranial Subclinical Vessel Diseases and Cognition in a Community-Based Sample of Japanese Men: Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA)

Author

Ito, Takahiro, primary, Fujiyoshi, Akira, additional, Ohkubo, Takayoshi, additional, Shiino, Akihiko, additional, Nozaki, Kazuhiko, additional, Miyagawa, Naoko, additional, Torii, Sayuki, additional, Hisamatsu, Takashi, additional, Miura, Katsuyuki, additional, and Ueshima, Hirotsugu, additional

Published
2019
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42. Association between Pulse Wave Velocity and Coronary Artery Calcification in Japanese men the Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA)

Author

TORII, Sayuki

Subjects
Coronary artery diseases (CAD), Cardiovascular diseases (CVD), Pulse wave velocity (PWV), cardiovascular system, cardiovascular diseases, Coronary artery calcification (CAC), Arterial stiffness
Abstract

Aim:Pulse wave velocity (PWV) is a simple and valid clinical method for assessing arterial stiffness. Coronary artery calcification (CAC) is an intermediate stage in the process leading to overt cardiovascular disease (CVD) and an established determinant of coronary artery disease. This study aimed to examine the association between PWV and CAC in a population-based sample of Japanese men., Methods:This is a cross-sectional study of 986 randomly selected men aged 40-79 years from Shiga, Japan. CVD-free participants were examined from 2006 to 2008. Brachial-ankle PWV (baPWV) was measured using an automatic waveform analyzer. CAC was assessed using computed tomography. Agatston scores ≥ 10 were defined as the presence of CAC., Results:Prevalence of CAC progressively increased with rising levels of baPWV: 20.6%, 41.7%, 56.3%, and 66.7% across baPWV quartiles ＜ 1378, 1378-1563, 1564-1849, and ＞ 1849 cm/s (P ＜ 0.001 for trend). Associations remained significant after adjusting for age and other factors, including body mass index, systolic blood pressure, pulse rate, total and high-density lipoprotein cholesterol, hemoglobin A1c, drinking, smoking and exercise status, and the use of medication to treat hypertension, dyslipidemia and diabetes (P=0.042 for trend). The optimal cutoff level of baPWV to detect CAC was 1612 cm/s using receiver operating characteristic curve analysis., Conclusions:Arterial stiffness as defined by an elevated baPWV is associated with an increased prevalence of CAC in a general population-based setting among Japanese men., 平成27年度

Published
2015
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44. Reduced Lung Function and Cerebral Small Vessel Disease in Japanese Men: the Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA)

Author

Seto-Yukimura Ruriko, Ogawa Emiko, Hisamatsu Takashi, Torii Sayuki, Shiino Akihiko, Nozaki Kazuhiko, Fujiyoshi Akira, Miura Katsuyuki, Nakano Yasutaka, Ueshima Hirotsugu, Seto-Yukimura Ruriko, Ogawa Emiko, Hisamatsu Takashi, Torii Sayuki, Shiino Akihiko, Nozaki Kazuhiko, Fujiyoshi Akira, Miura Katsuyuki, Nakano Yasutaka, and Ueshima Hirotsugu

Published
2018

46. Effectiveness of a Self-monitoring Device for Urinary Sodium-to-Potassium Ratio on Dietary Improvement in Free-Living Adults: a Randomized Controlled Trial

Author

Iwahori, Toshiyuki, primary, Ueshima, Hirotsugu, additional, Ohgami, Naoto, additional, Yamashita, Hideyuki, additional, Miyagawa, Naoko, additional, Kondo, Keiko, additional, Torii, Sayuki, additional, Yoshita, Katsushi, additional, Shiga, Toshikazu, additional, Ohkubo, Takayoshi, additional, Arima, Hisatomi, additional, and Miura, Katsuyuki, additional

Published
2018
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47. The Influence of the Japanese Nationwide Cardiovascular Prevention System Health Guidance on Smoking Cessation Among Smokers: A Propensity Score Matching Analysis

Author

Nakamura, Koshi, primary, Watanabe, Makoto, additional, Okuda, Nagako, additional, Yoshita, Katsushi, additional, Kabayama, Mai, additional, Torii, Sayuki, additional, Kuribayashi, Toru, additional, Itai, Kazuyoshi, additional, Kamide, Kei, additional, Miura, Katsuyuki, additional, and Okayama, Akira, additional

Published
2018
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49. Abstract P014: Lower eGFR and Proteinuria Were Independently Associated With Lower Cognitive Abilities in Community-dwelling Men in Japan: SESSA study

Author

Fujiyoshi, Akira, primary, Ohkubo, Takayoshi, additional, Miura, Katsuyuki, additional, Shiino, Akihiko, additional, Miyagawa, Naoko, additional, Takashima, Naoyuki, additional, Saitoh, Yoshino, additional, Torii, Sayuki, additional, Kadota, Aya, additional, Kadowaki, Sayaka, additional, Hisamatsu, Takashi, additional, Miyazawa, Itsuko, additional, Tooyama, Ikuo, additional, and Ueshima, Hirotsugu, additional

Published
2017
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