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3. Salvage Treatment After Local Breast Cancer Relapse

Author

Harder, F., Hünig, R., Laffer, U., Lüscher, N., de Roche, R., Torhorst, J., Herfarth, Ch., editor, Senn, H.-J., editor, Baum, M., editor, Diehl, V., editor, Gutzwiller, F., editor, Rajewsky, M. F., editor, Wannenmacher, M., editor, Senn, Hans-Jörg, editor, Gelber, Richard D., editor, Goldhirsch, Aron, editor, and Thürlimann, Beat, editor

Published
1993
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11. Long-term outcomes of breast cancer patients after endoscopic axillary lymph node dissection: a prospective analysis of 52 patients

Author

Langer, I., Kocher, T., Guller, U., Torhorst, J., Oertli, D., Harder, F., Zuber, M., Langer, I., Kocher, T., Guller, U., Torhorst, J., Oertli, D., Harder, F., and Zuber, M.

Abstract

Summary: Background. Reports on long-term outcomes after endoscopic axillary lymph node dissection (ALND) of breast cancer patients are still lacking in the medical literature. The objective of this prospective study was to assess the oncological and functional outcomes in breast cancer patients after endoscopic ALND. Methods. Fifty-five breast cancer patients were prospectively enrolled, of whom 52 were available for follow-up with a median of 71.9 months (range 11-96). The following oncological and functional endpoints were evaluated during follow-up at several time points: occurrence of local, axillary and distant metastases, seroma or infection, shoulder mobility (range of motion), numbness, pain, presence of lymphoedema as well as restriction in activities of daily living. Results. In 52 patients endoscopic ALND of level I and II was successfully performed. Two port-site metastases (2/52, 4%) occurred, one of which in a patient with negative axillary lymph nodes. The same patient suffered from the only axillary recurrence (1/52, 2%). Three patients (3/52, 6%) developed lymphoedema. No other functional adverse events (shoulder mobility, pain, numbness, hypertrophic scar) were noticed at the end of the observation period. Conclusion. The present investigation with long-term follow-up after endoscopic ALND - the first one in the literature - reveals minor morbidity, good functional and cosmetic results. In contrary to conventional surgery, the endoscopic procedure is associated with the occurrence of port-site metastases, not seen in the open approach. Axillary recurrences do not appear more frequently when compared with results after conventional ALND. In the meantime the less invasive sentinel lymph node (SLN) biopsy is the established standard technique in evaluating the axillary lymph node status

Published
2018

12. Retinoic Acid-Binding Protein in Human Breast Cancer and Dysplasia

Author

Huber, P. R., Geyer, E., Küng, W., Matter, A., Torhorst, J., and Eppenberger, U.

Abstract

Seventy-five specimens of human breast tissue were checked for the presence of cellular retinoic acid-binding protein (cRABP). Fifty-two percent of the primary carcinomas and 43% of the dysplastic breast lesions (stage MIl) contained detectable amounts of cRABP, whereas no cRABP was found in normal tissue. Sucrose gradient centrifugation and electrophoresis on agarose were used for analysis of the presence of cRABP. The cRABP of human origin (normal uterus and neoplastic mammary tissue) differed in its mobility in agarose electrophoresis from that of rat testis cRAB

Published
2017

21. High-resolution analysis of gene copy number changes across the genome in hundreds of tumors: CGH on cDNA microarrays followed by FISH analysis on tissue microarrays identify genes involved in DNA amplifications at 17q23 in breast cancer

Author

Kallioniemi, A.H., Monni, O.M., Kononen, J., Barlund, M., Mousses, S., Weaver, J.D., Bittner, M., Chen, Y., Torhorst, J., Sauter, G., and Kallioniemi, O-P.

Subjects
Genetic research -- Analysis, Human genetics -- Research, Biological sciences
Published
2000

39. Introduction: The EUROCARE II Study ( Editorial )

Author

Berrino, F., Gatta, G., Chessa, E., Valente, F., Capocaccia, R., Oberaigner, W., Storm, H., Aareleid, T., Hakulinen, T., Pottier, D., Mace Lesec'h, J., Faivre, J., Chaplain, G., Carli, P. M., Arveux, P., Esteve, J., Exbrayat, C., Raverdy, N., Kaatsch, P., Michaelis, J., Ziegler, H., Tryggvadottir, L., Tulinius, H., Crosignani, P., Micheli, A., Sant, M., Conti, E., Vercelli, M., Federico, Massimo, Mangone, L., PONZ DE LEON, Maurizio, De Lisi, V., Zanetti, R., Magnani, C., Gaf, L., Tumino, R., Falcini, F., Barchielli, A., De Angelis, G., Verdecchia, A., Pawlega, J., Rachtan, J., Bielska Lasota, M., Wronkowski, Z., Obsitnikova, A., Plesko, I., Pompe Kirn, V., Izarzugaza, I., Viladiu, P., Martinez Garcia, C., Garau, I., Ardanaz, E., Moreno, C., Galceran, J., Moller, T., Torhorst, J., Bouchardy, C., Raymond, L., Coebergh, J. W. W., Damhuis, R. A. M., Gould, A., Davies, T. W., Stockton, D., Coleman, M. P., Williams, E. M. I., Littler, J., Forman, D., Quinn, M. J., Roch, M., Smith, J., Bell, J., and Lawrence, G.

Subjects
Europe, Survival rates, Europe, Survival rates
Published
1998

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