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4. Das Komplementsystem bei radiologischer axSpA - Biomarker für die radiologische Progression? Post-hoc-Analyse der klinischen Studie: CONSUL - multizentrische, randomisierte, kontrollierte Studie von axSpA-Patienten mit einem hohen Risiko einer strukturellen Progression und Beginn der Behandlung mit einem TNF-i

Author

Proft, F, Mistegård, C, Troldborg, A, Loft, AG, Thiel, S, Muche, B, Rios Rodriguez, V, Torgutalp, M, Protopopov, M, Listing, J, Sieper, J, Poddubnyy, D, Proft, F, Mistegård, C, Troldborg, A, Loft, AG, Thiel, S, Muche, B, Rios Rodriguez, V, Torgutalp, M, Protopopov, M, Listing, J, Sieper, J, and Poddubnyy, D

Published
2023

6. POS0299 NEUROPATHIC AND NEUROPLASTIC PAIN COMPONENTS DETERMINE THE PRESENCE OF RESIDUAL SYMPTOMS IN PATIENTS WITH AXIAL SPONDYLOARTHRITIS RECEIVING BIOLOGICAL DISEASE-MODIFYING ANTI-RHEUMATIC DRUGS

Author

Al Mohamad, F., primary, Rios Rodriguez, V., additional, Haibel, H., additional, Protopopov, M., additional, Rademacher, J., additional, Sieper, J., additional, Torgutalp, M., additional, Käding, H., additional, Proft, F., additional, and Poddubnyy, D., additional

Published
2023
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8. POS0429 THE COMPLEMENT SYSTEM AND RESPONSE TO TNF INHIBITION IN PATIENTS WITH RADIOGRAPHIC AXIAL SPONDYLOARTHRITIS. POST HOC ANALYSIS FROM CONSUL, A LONGITUDINAL MULTI-CENTER RCT COHORT OF R-AXSPA-PATIENTS WITH A HIGH RISK OF STRUCTURAL PROGRESSION INITIATING TREATMENT WITH TNF-INHIBITOR

Author

Mistegaard, C. E., primary, Troldborg, A., additional, Loft, A. G., additional, Thiel, S., additional, Muche, B., additional, Rios Rodriguez, V., additional, Torgutalp, M., additional, Protopopov, M., additional, Listing, J., additional, Sieper, J., additional, Poddubnyy, D., additional, and Proft, F., additional

Published
2023
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9. POS0043 COMPLEMENT IN RADIOGRAPHIC AXSPA – BIOMARKERS OF RADIOGRAPHIC PROGRESSION? POST HOC ANALYSIS FROM CONSUL, A LONGITUDINAL MULTI-CENTER RANDOMIZED CONTROLLED TRIAL COHORT OF AXSPA-PATIENTS WITH A HIGH RISK OF STRUCTURAL PROGRESSION INITIATING TREATMENT WITH TNF-I

Author

Mistegaard, C. E., primary, Troldborg, A., additional, Loft, A. G., additional, Thiel, S., additional, Muche, B., additional, Rios Rodriguez, V., additional, Torgutalp, M., additional, Protopopov, M., additional, Listing, J., additional, Sieper, J., additional, Poddubnyy, D., additional, and Proft, F., additional

Published
2023
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10. Outcome of COVID-19 in Patients With Autoimmune Hepatitis: An International Multicenter Study

Author

Efe, C, Dhanasekaran, R, Lammert, C, Ebik, B, Higuera-de la Tijera, F, Aloman, C, Riza Caliskan, A, Peralta, M, Gerussi, A, Massoumi, H, Catana, A, Torgutalp, M, Purnak, T, Rigamonti, C, Gomez Aldana, A, Khakoo, N, Kacmaz, H, Nazal, L, Frager, S, Demir, N, Irak, K, Ellik, Z, Balaban, Y, Atay, K, Eren, F, Cristoferi, L, Batibay, E, Urzua, A, Snijders, R, Kiyici, M, Akyildiz, M, Ekin, N, Carr, R, Harputluoglu, M, Hatemi, I, Mendizabal, M, Silva, M, Idilman, R, Silveira, M, Drenth, J, Assis, D, Bjornsson, E, Boyer, J, Invernizzi, P, Levy, C, Schiano, T, Ridruejo, E, Wahlin, S, Efe C., Dhanasekaran R., Lammert C., Ebik B., Higuera-de la Tijera F., Aloman C., Riza Caliskan A., Peralta M., Gerussi A., Massoumi H., Catana A. M., Torgutalp M., Purnak T., Rigamonti C., Gomez Aldana A. J., Khakoo N., Kacmaz H., Nazal L., Frager S., Demir N., Irak K., Ellik Z. M., Balaban Y., Atay K., Eren F., Cristoferi L., Batibay E., Urzua A., Snijders R., Kiyici M., Akyildiz M., Ekin N., Carr R. M., Harputluoglu M., Hatemi I., Mendizabal M., Silva M., Idilman R., Silveira M., Drenth J. P. H., Assis D. N., Bjornsson E., Boyer J. L., Invernizzi P., Levy C., Schiano T. D., Ridruejo E., Wahlin S., Efe, C, Dhanasekaran, R, Lammert, C, Ebik, B, Higuera-de la Tijera, F, Aloman, C, Riza Caliskan, A, Peralta, M, Gerussi, A, Massoumi, H, Catana, A, Torgutalp, M, Purnak, T, Rigamonti, C, Gomez Aldana, A, Khakoo, N, Kacmaz, H, Nazal, L, Frager, S, Demir, N, Irak, K, Ellik, Z, Balaban, Y, Atay, K, Eren, F, Cristoferi, L, Batibay, E, Urzua, A, Snijders, R, Kiyici, M, Akyildiz, M, Ekin, N, Carr, R, Harputluoglu, M, Hatemi, I, Mendizabal, M, Silva, M, Idilman, R, Silveira, M, Drenth, J, Assis, D, Bjornsson, E, Boyer, J, Invernizzi, P, Levy, C, Schiano, T, Ridruejo, E, Wahlin, S, Efe C., Dhanasekaran R., Lammert C., Ebik B., Higuera-de la Tijera F., Aloman C., Riza Caliskan A., Peralta M., Gerussi A., Massoumi H., Catana A. M., Torgutalp M., Purnak T., Rigamonti C., Gomez Aldana A. J., Khakoo N., Kacmaz H., Nazal L., Frager S., Demir N., Irak K., Ellik Z. M., Balaban Y., Atay K., Eren F., Cristoferi L., Batibay E., Urzua A., Snijders R., Kiyici M., Akyildiz M., Ekin N., Carr R. M., Harputluoglu M., Hatemi I., Mendizabal M., Silva M., Idilman R., Silveira M., Drenth J. P. H., Assis D. N., Bjornsson E., Boyer J. L., Invernizzi P., Levy C., Schiano T. D., Ridruejo E., and Wahlin S.

Abstract

Background and Aims: Data regarding outcome of COVID-19 in patients with autoimmune hepatitis (AIH) are lacking. Approach and Results: We performed a retrospective study on patients with AIH and COVID-19 from 34 centers in Europe and the Americas. We analyzed factors associated with severe COVID-19 outcomes, defined as the need for mechanical ventilation, intensive care admission, and/or death. The outcomes of patients with AIH were compared to a propensity score–matched cohort of patients without AIH but with chronic liver diseases (CLD) and COVID-19. The frequency and clinical significance of new-onset liver injury (alanine aminotransferase > 2 × the upper limit of normal) during COVID-19 was also evaluated. We included 110 patients with AIH (80% female) with a median age of 49 (range, 18-85) years at COVID-19 diagnosis. New-onset liver injury was observed in 37.1% (33/89) of the patients. Use of antivirals was associated with liver injury (P = 0.041; OR, 3.36; 95% CI, 1.05-10.78), while continued immunosuppression during COVID-19 was associated with a lower rate of liver injury (P = 0.009; OR, 0.26; 95% CI, 0.09-0.71). The rates of severe COVID-19 (15.5% versus 20.2%, P = 0.231) and all-cause mortality (10% versus 11.5%, P = 0.852) were not different between AIH and non-AIH CLD. Cirrhosis was an independent predictor of severe COVID-19 in patients with AIH (P < 0.001; OR, 17.46; 95% CI, 4.22-72.13). Continuation of immunosuppression or presence of liver injury during COVID-19 was not associated with severe COVID-19. Conclusions: This international, multicenter study reveals that patients with AIH were not at risk for worse outcomes with COVID-19 than other causes of CLD. Cirrhosis was the strongest predictor for severe COVID-19 in patients with AIH. Maintenance of immunosuppression during COVID-19 was not associated with increased risk for severe COVID-19 but did lower the risk for new-onset liver

Published
2021

12. Vergleich des Effekts einer konsequenten Behandlung mit NSAIDs in Kombination mit einer Anti-TNF-Therapie im Vergleich zu einer alleinigen Anti-TNF-Therapie auf das Fortschreiten von strukturellen Schäden an der Wirbelsäule über einen Zeitraum von zwei Jahre bei Patienten mit ankylosierender Spondylitis (CONSUL) - eine offene, randomisierte, kontrollierte, multizentrische Studie

Author

Proft, F, Muche, B, Rios Rodriguez, V, Torgutalp, M, Protopopov, M, Listing, J, Verba, M, Kiltz, U, Brandt-Jürgens, J, Sieburg, M, Jacki, SH, Sieper, J, Poddubnyy, D, Proft, F, Muche, B, Rios Rodriguez, V, Torgutalp, M, Protopopov, M, Listing, J, Verba, M, Kiltz, U, Brandt-Jürgens, J, Sieburg, M, Jacki, SH, Sieper, J, and Poddubnyy, D

Published
2022

14. Alles gleich oder doch ganz anders? Gemeinsamkeiten und Unterschiede von Morbus Crohn und Colitis Ulcerosa bei Spondyloarthritis: Eine Analyse der weltweiten ASAS-perSpA-Studie

Author

Rios Rodriguez, V, Duran, TI, Torgutalp, M, Lopez-Medina, C, Dougados, M, Kishimoto, M, Ono, K, Lüders, S, Protopopov, M, Haibel, H, Rademacher, J, Poddubnyy, D, Proft, F, Rios Rodriguez, V, Duran, TI, Torgutalp, M, Lopez-Medina, C, Dougados, M, Kishimoto, M, Ono, K, Lüders, S, Protopopov, M, Haibel, H, Rademacher, J, Poddubnyy, D, and Proft, F

Published
2022

17. Eine Therapie mit nicht-steroidalen Antirheumatika ist mit einer Verzögerung der radiografischen Progression der Wirbelsäule bei Patienten mit axialer Spondyloarthritis assoziiert: 10-Jahres-Ergebnisse der GErman SPondyloarthritis Inception Cohort

Author

Torgutalp, M, Rios Rodriguez, V, Dilbaryan, A, Proft, F, Protopopov, M, Verba, M, Rademacher, J, Haibel, H, Sieper, J, Rudwaleit, M, Poddubnyy, D, Torgutalp, M, Rios Rodriguez, V, Dilbaryan, A, Proft, F, Protopopov, M, Verba, M, Rademacher, J, Haibel, H, Sieper, J, Rudwaleit, M, and Poddubnyy, D

Published
2022

19. OP0152 A DEEP LEARNING FRAMEWORK FOR MRI DETECTION OF ACTIVE INFLAMMATORY AND STRUCTURAL CHANGES IN THE SACROILIAC JOINT CONSISTENT WITH AXIAL SPONDYLOARTHRITIS: AN INTERNATIONAL COLLABORATIVE STUDY

Author

Bressem, K. K., primary, Adams, L., additional, Proft, F., additional, Hermann, K. G. A., additional, Diekhoff, T., additional, Spiller, L., additional, Niehues, S., additional, Makowski, M., additional, Hamm, B., additional, Protopopov, M., additional, Rios Rodriguez, V., additional, Haibel, H., additional, Rademacher, J., additional, Torgutalp, M., additional, Lambert, R. G., additional, Baraliakos, X., additional, Maksymowych, W. P., additional, Vahldiek, J. L., additional, and Poddubnyy, D., additional

Published
2022
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21. OP0018 COMPARISON OF THE EFFECT OF TREATMENT WITH NSAIDs ADDED TO ANTI-TNF THERAPY VERSUS ANTI-TNF THERAPY ALONE ON PROGRESSION OF STRUCTURAL DAMAGE IN THE SPINE OVER TWO YEARS IN PATIENTS WITH ANKYLOSING SPONDYLITIS (CONSUL) – AN OPEN-LABEL, RANDOMIZED CONTROLLED, MULTICENTER TRIAL

Author

Proft, F., primary, Muche, B., additional, Rios Rodriguez, V., additional, Torgutalp, M., additional, Protopopov, M., additional, Listing, J., additional, Verba, M., additional, Kiltz, U., additional, Brandt-Juergens, J., additional, Sieburg, M., additional, Jacki, S. H., additional, Sieper, J., additional, and Poddubnyy, D., additional

Published
2022
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22. POS0970 SAME OR DIFFERENT? ANALYSIS OF SIMILARITIES AND DIFFERENCES OF CROHN’S DISEASE AND ULCERATIVE COLITIS IN SPONDYLOARTHRITIS: AN ANCILLARY ANALYSIS FROM THE WORLDWIDE ASAS-perSpA STUDY.

Author

Rios Rodriguez, V., primary, Izci Duran, T., additional, Torgutalp, M., additional, López-Medina, C., additional, Dougados, M., additional, Kishimoto, M., additional, Ono, K., additional, Lüders, S., additional, Protopopov, M., additional, Haibel, H., additional, Rademacher, J., additional, Poddubnyy, D., additional, and Proft, F., additional

Published
2022
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27. OP0021 TREATMENT WITH NON-STEROIDAL ANTI-INFLAMMATORY DRUGS IS ASSOCIATED WITH RETARDATION OF RADIOGRAPHIC SPINAL PROGRESSION IN PATIENTS WITH AXIAL SPONDYLOARTHRITIS: 10-YEAR RESULTS FROM THE GERMAN SPONDYLOARTHRITIS INCEPTION COHORT

Author

Torgutalp, M., primary, Rios Rodriguez, V., additional, Dilbaryan, A., additional, Proft, F., additional, Protopopov, M., additional, Verba, M., additional, Rademacher, J., additional, Haibel, H., additional, Sieper, J., additional, Rudwaleit, M., additional, and Poddubnyy, D., additional

Published
2022
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34. Patient characteristics in Beh��et���s Syndrome and their associations with major organ involvement: a single-centre experience of 2118 cases

Author

Torgutalp, M, Ero��lu, D��, Sezer, S, Yayla, ME, Karata��, G, ��zel, EM, Din��er, ABK, Y��ksel, ML, G��l��ks��z, EGA, Y��lmaz, R, Turgay, TM, K��n��kl��, G, and Ate��, A

Abstract

Objectives: To evaluate the demographic and clinical characteristics of patients with Beh��et���s syndrome (BS), and to define their associations with the presence of major organ involvement (MOI). Method: Medical records of 2118 patients (964 males, 1154 females) were analysed retrospectively. MOI was defined as the presence of at least one of vascular, eye, nervous, or gastrointestinal system involvement. Univariable and multivariable binary and ordinal logistic regression analyses were applied to assess the factors that were potentially associated with MOI. Results: The mean �� sd age at diagnosis was 30.5 �� 9.4 years. Genital ulcer and joint involvement were more common in females (both p Conclusion: Male gender and positive smoking history have a significant influence on the presence of MOI in patients with BS.

Published
2021
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35. Patient characteristics in Behçet’s Syndrome and their associations with major organ involvement: a single-centre experience of 2118 cases

Author

Torgutalp, M, primary, Eroğlu, DŞ, additional, Sezer, S, additional, Yayla, ME, additional, Karataş, G, additional, Özel, EM, additional, Dinçer, ABK, additional, Yüksel, ML, additional, Gülöksüz, EGA, additional, Yılmaz, R, additional, Turgay, TM, additional, Kınıklı, G, additional, and Ateş, A, additional

Published
2021
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36. Frequency of disease flares under long-term anti-TNF therapy in patients with early axial spondyloarthritis: results from the etanercept versus sulfasalazine in early axial spondyloarthritis trial

Author

Proft, F., Torgutalp, M., Weiss, A., Protopopov, M., Rodriguez, V. Rios, Haibel, H., Hermann, K., Althoff, C., Behmer, O., Sieper, J., and Poddubnyy, D.

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Introduction: Disease flares in axial spondyloarthritis (axSpA) might occur even in patients with otherwise stable disease receiving highly effective anti-inflammatory therapy such as TNF inhibitors. The frequency of disease flares, especially in patients with axSpA receiving long-term stable therapy,[for full text, please go to the a.m. URL], Deutscher Rheumatologiekongress 2020, 48. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 34. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh)

Published
2020

37. Clinical course of early axial spondyloarthritis over ten years: long-term results from the German Spondyloarthritis Inception Cohort

Author

Poddubnyy, D, Rios Rodriguez, V, Torgutalp, M, Verba, M, Callhoff, J, Protopopov, M, Proft, F, Rademacher, J, Haibel, H, Sieper, J, and Rudwaleit, M

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Introduction: Previous studies showed that patients with non-radiographic and radiographic axial spondyloarthritis (nr- and r-axSpA) have similar disease burden and similar response to anti-inflammatory therapy given similar level of inflammatory activity. Only little is known, however, about long-term[for full text, please go to the a.m. URL], Deutscher Rheumatologiekongress 2020, 48. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 34. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh)

Published
2020
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38. Outcome of COVID-19 in patients with autoimmune hepatitis: an international multi-centre study

Author

Akyıldız, Murat, Efe, C.; Dhanasekaran, R.; Lammert, C.; Ebi, B.; Higuera-de la Tijera, F.; Aloman, C.; Çalışkan, A. R.; Peralta, M.; Gerussi, A.; Massoumi, H.; Catana, A. M.; Torgutalp, M.; Pürnak T.; Rigamonti, C.; Aldana, A. J. G.; Khakoo, N.; Kaçmaz, H.; Nazal, L.; Frager, S.; Demir, N.; Irak, K.; Ellik, Z. M.; Balaban, Y.; Atay, K.; Eren, F.; Cristoferi, L.; Batıbay, E.; Urzua, Á.; Snijders, R.; Kıyıcı, M.; Ekin, N.; Carr, R. M.; Harputoğlu, M.; Hatemi, İ.; Mendizabal, M.; Silva, M.; İdilman, R.; Silveira, M.; Drenth, J. P. H.; Assis, D. N.; Björnsson, E.; Boyer, J. L.; Invernizzi, P.; Levy, C.; Schiano, T. D.; Ridruejo, E.; Wahlin, S., Akyıldız, Murat, and Efe, C.; Dhanasekaran, R.; Lammert, C.; Ebi, B.; Higuera-de la Tijera, F.; Aloman, C.; Çalışkan, A. R.; Peralta, M.; Gerussi, A.; Massoumi, H.; Catana, A. M.; Torgutalp, M.; Pürnak T.; Rigamonti, C.; Aldana, A. J. G.; Khakoo, N.; Kaçmaz, H.; Nazal, L.; Frager, S.; Demir, N.; Irak, K.; Ellik, Z. M.; Balaban, Y.; Atay, K.; Eren, F.; Cristoferi, L.; Batıbay, E.; Urzua, Á.; Snijders, R.; Kıyıcı, M.; Ekin, N.; Carr, R. M.; Harputoğlu, M.; Hatemi, İ.; Mendizabal, M.; Silva, M.; İdilman, R.; Silveira, M.; Drenth, J. P. H.; Assis, D. N.; Björnsson, E.; Boyer, J. L.; Invernizzi, P.; Levy, C.; Schiano, T. D.; Ridruejo, E.; Wahlin, S.

Abstract

Background: data regarding outcome of Coronavirus disease 2019 (COVID-19) in patients with autoimmune hepatitis (AIH) are lacking. Patients and methods: we performed a retrospective study on AIH patients with COVID-19 from 34 centres in Europe and the Americas. We analyzed factors associated with severe COVID-19 outcomes defined as the need for mechanical ventilation, intensive care admission, and/or death. The outcomes of patients with AIH were compared to a propensity-score matched cohort of non-AIH patients with chronic liver diseases (CLD) and COVID-19. The frequency and clinical significance of new-onset liver injury (alanine aminotransferase>2xupper limit of normal) during COVID-19 was also evaluated. Results: we included 110 AIH patients (80%,female) with a median age of 49 (range:18-85) years at COVID-19 diagnosis. New-onset liver injury was observed in 37.1% (33/89) of the patients. Use of antivirals was associated with liver injury (p=0.041; odds ratio (OR) 3.36[1.05-10.78]) while continued immunosuppression during COVID-19 was associated with a lower rate of liver injury (p=0.009; OR 0.26[0.09-0.71]). The rates of severe COVID-19 (15.5% vs 20.2% p=0.231) and all-cause mortality (10% vs 11.5%; p=0.852) were not different between AIH and non-AIH CLD. Cirrhosis was an independent predictor of severe COVID-19 in patients with AIH (p<0.001; OR 17.46[4.22-72.13]). Continuation of immunosuppression or presence of liver injury during COVID-19 was not associated with severe COVID-19. Conclusions: this international, multi-center study reveals that patients with AIH were not at risk for worse outcomes with COVID-19 than other causes of CLD. Cirrhosis was the strongest predictor for severe COVID-19 in AIH patients. Maintenance of immunosuppression during COVID-19 was not associated with increased risk for severe COVID-19, but did lower the risk for new-onset liver injury during COVID-19.

Published
2021

39. Outcome of COVID-19 in Patients With Autoimmune Hepatitis: An International Multicenter Study

Author

Efe, C., Dhanasekaran, R., Lammert, C., Ebik, B., Higuera-de la Tijera, F., Aloman, C., Calışkan, A. Rıza, Peralta, M., Gerussi, A., Massoumi, H., Catana, A.M., Torgutalp, M., Purnak, T., Rigamonti, C., Aldana, A.J. Gomez, Khakoo, N., Kacmaz, H., Nazal, L., Frager, S., Demir, N., Irak, K., Ellik, Z.M., Balaban, Y., Atay, K., Eren, F., Cristoferi, L., Batıbay, E., Urzua, Á., Snijders, R.J.A.L.M., Kıyıcı, M., Akyıldız, M., Ekin, N., Carr, R.M., Harputluoğlu, M., Hatemi, I., Mendizabal, M., Silva, M., Idilman, R., Silveira, M., Drenth, J.P.H., Assis, D.N., Björnsson, E., Boyer, J.L., Invernizzi, P., Levy, C., Schiano, T.D., Ridruejo, E., Wahlin, S., Efe, C., Dhanasekaran, R., Lammert, C., Ebik, B., Higuera-de la Tijera, F., Aloman, C., Calışkan, A. Rıza, Peralta, M., Gerussi, A., Massoumi, H., Catana, A.M., Torgutalp, M., Purnak, T., Rigamonti, C., Aldana, A.J. Gomez, Khakoo, N., Kacmaz, H., Nazal, L., Frager, S., Demir, N., Irak, K., Ellik, Z.M., Balaban, Y., Atay, K., Eren, F., Cristoferi, L., Batıbay, E., Urzua, Á., Snijders, R.J.A.L.M., Kıyıcı, M., Akyıldız, M., Ekin, N., Carr, R.M., Harputluoğlu, M., Hatemi, I., Mendizabal, M., Silva, M., Idilman, R., Silveira, M., Drenth, J.P.H., Assis, D.N., Björnsson, E., Boyer, J.L., Invernizzi, P., Levy, C., Schiano, T.D., Ridruejo, E., and Wahlin, S.

Abstract

Contains fulltext : 235669.pdf (Publisher’s version ) (Closed access), BACKGROUND AND AIMS: Data regarding outcome of COVID-19 in patients with autoimmune hepatitis (AIH) are lacking. APPROACH AND RESULTS: We performed a retrospective study on patients with AIH and COVID-19 from 34 centers in Europe and the Americas. We analyzed factors associated with severe COVID-19 outcomes, defined as the need for mechanical ventilation, intensive care admission, and/or death. The outcomes of patients with AIH were compared to a propensity score-matched cohort of patients without AIH but with chronic liver diseases (CLD) and COVID-19. The frequency and clinical significance of new-onset liver injury (alanine aminotransferase > 2 × the upper limit of normal) during COVID-19 was also evaluated. We included 110 patients with AIH (80% female) with a median age of 49 (range, 18-85) years at COVID-19 diagnosis. New-onset liver injury was observed in 37.1% (33/89) of the patients. Use of antivirals was associated with liver injury (P = 0.041; OR, 3.36; 95% CI, 1.05-10.78), while continued immunosuppression during COVID-19 was associated with a lower rate of liver injury (P = 0.009; OR, 0.26; 95% CI, 0.09-0.71). The rates of severe COVID-19 (15.5% versus 20.2%, P = 0.231) and all-cause mortality (10% versus 11.5%, P = 0.852) were not different between AIH and non-AIH CLD. Cirrhosis was an independent predictor of severe COVID-19 in patients with AIH (P < 0.001; OR, 17.46; 95% CI, 4.22-72.13). Continuation of immunosuppression or presence of liver injury during COVID-19 was not associated with severe COVID-19. CONCLUSIONS: This international, multicenter study reveals that patients with AIH were not at risk for worse outcomes with COVID-19 than other causes of CLD. Cirrhosis was the strongest predictor for severe COVID-19 in patients with AIH. Maintenance of immunosuppression during COVID-19 was not associated with increased risk for severe COVID-19 but did lower the risk for new-onset liver injury during COVID-19.

Published
2021

43. OP0254 AN ARTIFICIAL NEURAL NETWORK FOR THE DETECTION OF DEFINITE RADIOGRAPHIC SACROILIITIS WITH HIGH SPECIFICITY IN THE DIAGNOSTIC SETTING

Author

Vahldiek, J. L., primary, Bressem, K. K., additional, Niehues, S., additional, Adams, L., additional, Spiller, L., additional, Protopopov, M., additional, Rios Rodriguez, V., additional, Muche, B., additional, Rademacher, J., additional, Haibel, H., additional, Torgutalp, M., additional, Proft, F., additional, and Poddubnyy, D., additional

Published
2021
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45. OP0139 A TIME-SHIFTED EFFECT OF TUMOR NECROSIS FACTOR INHIBITORS ON RADIOGRAPHIC SPINAL PROGRESSION IN PATIENTS WITH AXIAL SPONDYLOARTHRITIS: LONG-TERM RESULTS FROM THE GERMAN SPONDYLOARTHRITIS INCEPTION COHORT

Author

Poddubnyy, D., primary, Rios Rodriguez, V., additional, Torgutalp, M., additional, Dilbaryan, A., additional, Verba, M., additional, Proft, F., additional, Protopopov, M., additional, Rademacher, J., additional, Haibel, H., additional, Sieper, J., additional, and Rudwaleit, M., additional

Published
2021
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46. POS0241 VALIDATION OF THE ANKYLOSING SPONDYLITIS DISEASE ACTIVITY SCORE WITH A QUICK QUANTITATIVE C-REACTIVE PROTEIN ASSAY (ASDAS-QCRP) IN PATIENTS WITH AXIAL SPONDYLOARTHRITIS (AXSPA): A PROSPECTIVE, NATIONAL, MULTICENTER STUDY

Author

Proft, F., primary, Schally, J., additional, Brandt, H. C., additional, Brandt-Juergens, J., additional, Burmester, G. R., additional, Haibel, H., additional, Käding, H., additional, Karberg, K., additional, Lüders, S., additional, Muche, B., additional, Protopopov, M., additional, Rademacher, J., additional, Rios Rodriguez, V., additional, Torgutalp, M., additional, Verba, M., additional, Zinke, S., additional, and Poddubnyy, D., additional

Published
2021
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47. OP0137 TUMOR NECROSIS FACTOR INHIBITORS SHOW A DELAYED EFFECT ON RADIOGRAPHIC SACROILIITIS PROGRESSION IN PATIENTS WITH EARLY AXIAL SPONDYLOARTHRITIS: 10-YEAR RESULTS FROM THE GERMAN SPONDYLOARTHRITIS INCEPTION COHORT

Author

Torgutalp, M., primary, Rios Rodriguez, V., additional, Verba, M., additional, Protopopov, M., additional, Proft, F., additional, Rademacher, J., additional, Haibel, H., additional, Rudwaleit, M., additional, Sieper, J., additional, and Poddubnyy, D., additional

Published
2021
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48. POS0453 VALIDATION OF THE SIMPLIFIED DISEASE ACTIVITY INDEX (SDAI) WITH A QUICK QUANTITATIVE C-REACTIVE PROTEIN ASSAY (SDAI-Q) IN PATIENTS WITH RHEUMATOID ARTHRITIS: A NATIONAL, MULTICENTER STUDY

Author

Schally, J., primary, Brandt, H. C., additional, Brandt-Juergens, J., additional, Burmester, G. R., additional, Haibel, H., additional, Käding, H., additional, Karberg, K., additional, Lüders, S., additional, Muche, B., additional, Protopopov, M., additional, Rios Rodriguez, V., additional, Torgutalp, M., additional, Verba, M., additional, Zinke, S., additional, Poddubnyy, D., additional, and Proft, F., additional

Published
2021
Full Text
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