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1,628 results on '"Topazian, Mark"'

3. Global prevalence and characteristics of infections and clinical outcomes in hospitalised patients with cirrhosis: a prospective cohort study for the CLEARED Consortium

Author

Kumar, Shiva, Gadano, Adrián, Marciano, Sebastián, Tudehope, Fiona, Prudence, Alexander, Gibson, Robert, Zekry, Amany, Doyle, Adam, Si, Hooi Ling, Kim, Yu Sung, Gofton, Cameron, Riordan, Stephen, MacQuillan, Gerry, Al-Tamimi, Hala, Michalczuk, Matheus, Farias, Alberto, Zitelli, Patricia, Pereira, Gustavo, Victor, Livia, Bera, Chinmay, Faisal, Nabiha, Dahiya, Monica, Tandon, Puneeta, Lohoues, Marie Jeanne, Lah, Ponan Claude Regis, Benítez, Carlos, Arrese, Marco, Guan, Jing, Xian, Yongchao, Zhu, Chuanwu, Wang, Yingling, Su, Man, Su, Minghua, Wang, Xinrui, Gao, Yanhang, Peng, Feng, Jiang, Yongfang, Zhao, Caiyan, Wang, Wei, Yin, Dedong, Wang, Lei, Lu, Mingqin, Cai, Yijing, Guo, Feng, Wang, Xiaozhong, Zhang, Ningping, Zhang, Wanqin, Dong, Fuchen, Li, Hai, Liu, Jing, Zheng, Xin, Tang, Hong, Yan, Libo, Xu, Bin, Wei, Linlin, Xu, Zhen, Gao, Zhiliang, Gao, Haibing, Lin, Minghua, Rao, Qunfang, Wu, Xiaoping, Li, Beiling, Chen, Jinjun, Liu, Chenghai, Zhang, Yanyun, Deng, Huan, Hu, Peng, Wang, Jian, Li, Jie, Bettinger, Dominik, Schultheiß, Michael, Belimi, Hibat Allah, Debzi, Nabil, Mostafa, Alaa, Fouad, Yasser, Fisseha, Henok, Venkatachalapathy, Suresh Vasan, Aravinthan, Aloysious D, Rajoriya, Neil, Faulkes, Rosemary, Leith, Damien, Forrest, Ewan, Danielle, Adebayo, Kennedy, James, Yung, Diana, Alexopoulou, Alexandra, Mani, Iliana, Fung, James, Katchman, Helena, Rabinowich, Liane, Jhaveri, Ajay, Nagral, Aabha, Kulkarni, Anand, Sharma, Mithun, Sarin, Shiv K, Goel, Ashish, Eapen, C E, Duseja, Ajay, Gandotra, Akash, Saraya, Anoop, yegurla, Jatin, Jothimani, Dinesh, Rela, Mohammad, Arora, Anil, Kumar, Ashish, Roy, Akash, Dhiman, R K, Anand, A C, Praharaj, Dibyalochan, Cabrera, Araceli Bravo, Hueso, Sarai Gonzalez, Hérnandez, José Luis Pérez, Gutierrez, Oscar Morales, Ramos-Pineda, Abraham, Zazueta, Godolfino Miranda, Barradas, Mauricio Castillo, Made, Lilian Torres, Velazquez, Rene Male, Félix-Tellez, Francisco, Velasco, José Antonio Velarde-Ruiz, Cordova-Gallardo, Jacqueline, Rajaram, Ruveena, Afendi, Nik Arsyad Nik Muhamad, Nyam, David P, Okeke, Edith N, Allam, Dalia, Patwa, Yashwi Haresh Kumar, Tan, Hiang Keat, Lun, Liou Wei, Ho, Wei Ling Danielle, Wong, Yu Jun, Thanapirom, Kessarin, Teerasarntipan, Tongluk, Haktaniyan, Busra, Gunduz, Feyza, Aslan, Rahmi, Yildirim, Abdullah Emre, Barutcu, Sezgin, Uysal, Alper, Karasu, Zeki, Ucbilek, Enver, Kosay, Tolga, Dinçer, Dinç, Adanır, Haydar, Albhaisi, Somaya, Fallahadeh, Mohammad Amin, Asrani, Sumeet, Reddy, K Rajender, Shaw, Jawaid, Vargas, Hugo, Filipek, Natalia, Biggins, Scott W, Thuluvath, Paul, Sheshadri, Somya, Wegermann, Kara, Kappus, Matthew, Keaveny, Andrew, Rojo, Andres, Negrillo, Ricardo Cabello, Verna, Elizabeth, Cao, Zhujun, Wong, Florence, Choudhury, Ashok K, Kamath, Patrick S, Topazian, Mark, Torre, Aldo, Hayes, Peter C, George, Jacob, Idilman, Ramazan, Seto, Wai-Kay, Desalegn, Hailemichael, Alvares-da-Silva, Mario Reis, Bush, Brian J, Thacker, Leroy R, Xie, Qing, and Bajaj, Jasmohan S

Published
2024
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4. Pancreatitis pain quality changes at year 1 follow-up, but GP130 remains a biomarker for pain

Author

Saloman, Jami L, Jennings, Kristofer, Stello, Kimberly, Li, Shuang, Evans Phillips, Anna, Hall, Kristen, Fogel, Evan L., Vege, Santhi Swaroop, Andersen, Dana K., Fisher, William E., Forsmark, Christopher E., Hart, Phil A., Pandol, Stephen J., Park, Walter G., Topazian, Mark D., Van Den Eeden, Stephen K., Serrano, Jose, Conwell, Darwin L., Li, Liang, and Yadav, Dhiraj

Published
2024
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5. Diagnosis of chronic pancreatitis using semi-quantitative MRI features of the pancreatic parenchyma: results from the multi-institutional MINIMAP study

Author

Tirkes, Temel, Yadav, Dhiraj, Conwell, Darwin L., Territo, Paul R., Zhao, Xuandong, Persohn, Scott A., Dasyam, Anil K., Shah, Zarine K., Venkatesh, Sudhakar K., Takahashi, Naoki, Wachsman, Ashley, Li, Liang, Li, Yan, Pandol, Stephen J., Park, Walter G., Vege, Santhi Swaroop, Hart, Phil A., Topazian, Mark, Andersen, Dana K., and Fogel, Evan L.

Published
2023
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7. Circulating immune signatures in chronic pancreatitis with and without preceding acute pancreatitis: A pilot study

Author

Hagn-Meincke, Rasmus, Yadav, Dhiraj, Andersen, Dana K., Vege, Santhi Swaroop, Fogel, Evan L., Serrano, Jose, Bellin, Melena D., Topazian, Mark D., Conwell, Darwin L., Li, Liang, Van Den Eeden, Stephen K., Drewes, Asbjørn M., Pandol, Stephen J., Forsmark, Chris E., Fisher, William E., Hart, Phil A., Olesen, Søren S., and Park, Walter G.

Published
2024
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8. Distinct Serum Immune Profiles Define the Spectrum of Acute and Chronic Pancreatitis From the Multicenter Prospective Evaluation of Chronic Pancreatitis for Epidemiologic and Translational Studies (PROCEED) Study

Author

Li, Liang, Yadav, Dhiraj, Conwell, Darwin L., Hart, Phil A., Vege, Santhi Swaroop, Fogel, Evan L., Serrano, Jose, Andersen, Dana, Bellin, Melena D., Topazian, Mark, Van Den Eeden, Stephen K., Pandol, Stephen J., Forsmark, Chris, Fisher, William E., Park, Walter G., Lee, Bomi, Jones, Elaina K., Manohar, Murli, Topazian, Mark D., Forsmark, Chris E., Husain, Sohail Z., and Habtezion, Aida

Published
2023
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12. Serum Biomarkers of Nociceptive and Neuropathic Pain in Chronic Pancreatitis

Author

Saloman, Jami L., Li, Yan, Stello, Kimberly, Li, Wenhao, Li, Shuang, Phillips, Anna Evans, Hall, Kristen, Fogel, Evan L., Vege, Santhi Swaroop, Li, Liang, Andersen, Dana K., Fisher, William E., Forsmark, Christopher E., Hart, Phil A., Pandol, Stephen J., Park, Walter G., Topazian, Mark D., Van Den Eeden, Stephen K., Serrano, Jose, Conwell, Darwin L., and Yadav, Dhiraj

Published
2023
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14. Global disparities in mortality and liver transplantation in hospitalised patients with cirrhosis: a prospective cohort study for the CLEARED Consortium

Author

Sarin, Shiv K, Kumar, Shiva, Marciano, Sebastián, Gadano, Adrián, Tudehope, Fiona, Gibson, Robert, Prudence, Alexander, Doyle, Adam, Si, Hooi Ling, Riordan, Stephen, Farias, Alberto, Zitelli, Patricia, Bera, Chinmay, Faisal, Nabiha, Tandon, Puneeta, Dahiya, Monica, Lohoues, Marie Jeanne, Lah, Ponan Claude Regis, Benítez, Carlos, Arrese, Marco, Xian, Yongchao, Guan, Jin, Zhu, Chuanwu, Wang, Yingling, Su, Minghua, Su, Man, Gao, Yanhang, Wang, Xinrui, Jiang, Yongfang, Peng, Feng, Zhao, Caiyan, Wang, Wei, Wang, Lei, Yin, Dedong, Lu, Mingqin, Cai, Yijing, Zhang, Ningping, Zhang, Wanqin, Li, Hai, Dong, Fuchen, Zheng, Xin, Liu, Jing, Tang, Hong, Yan, Libo, Xu, Bin, Wei, Linlin, Gao, Zhiliang, Xu, Zhen, Lin, Minghua, Gao, Haibin, Chen, Jinjun, Li, Beiling, Liu, Chenghai, Zhang, Yanyun, Hu, Peng, Deng, Huan, Belimi, Hibat Allah, Debzi, Nabil, Fisseha, Henok, Aravinthan, Aloysious D, Venkatachalapathy, Suresh Vasan, Rajoriya, Neil, Faulkes, Rosemary, Leith, Damien, Forrest, Ewan, Adebayo, Danielle, Kennedy, James, Yung, Diana, Seto, Wai-Kay, Fung, James, Katchman, Helena, Rabinowich, Liane, Nagral, Aabha, Jhaveri, Ajay, Kulkarni, Anand, Sharma, Mithun, Eapen, C E, Goel, Ashish, Gandotra, Akash, Duseja, Ajay, Saraya, Anoop, Yegurla, Jatin, Rela, Mohamed, Jothimani, Dinesh, Arora, Anil, Kumar, Ashish, Dhiman, Radha Krishan, Roy, Akash, Anand, Anil C, Praharaj, Dibyalochan, Hueso, Sarai Gonzalez, Cabrera, Araceli Bravo, Pérez Hérnandez, José Luis, Gutierrez, Oscar Morales, Miranda Zazueta, Godolfino, Ramos-Pineda, Abraham, Castillo Barradas, Mauricio, Velazquez, Rene Male, Made, Lilian Torres, Velarde-Ruiz Velasco, José Antonio, Félix-Tellez, Francisco, Cordova-Gallardo, Jacqueline, Rajaram, Ruveena, Nik Muhamad Afendi, Nik Arsyad, Okeke, Edith N, Nyam, David P, Allam, Dalia, Kumar Patwa, Yashwi Haresh, Tan, Hiang Keat, Liou, Wei Lun, Treeprasertsuk, Sombat, Wejnaruemarn, Salisa, Haktaniyan, Busra, Gunduz, Feyza, Aslan, Rahmi, Yildirim, Abdullah Emre, Barutcu, Sezgin, Karasu, Zeki, Uysal, Alper, Ucbilek, Enver, Kosay, Tolga, Adanir, Haydar, Dinçer, Dinç, Albhaisi, Somaya, Asrani, Sumeet, Fallahadeh, Mohammad Amin, Reddy, K Rajender, Rahematpura, Suditi, Shaw, Jawaid, Vargas, Hugo E., Bayne, David, Biggins, Scott W, Filipek, Natalia, Thuluvath, Paul, Sheshadri, Somya, Keaveny, Andrew, Duarte Rojo, Andres, Cabello Negrillo, Ricardo, Bajaj, Jasmohan S, Choudhury, Ashok K, Xie, Qing, Kamath, Patrick S, Topazian, Mark, Hayes, Peter C, Torre, Aldo, Desalegn, Hailemichael, Idilman, Ramazan, Cao, Zhujun, Alvares-da-Silva, Mario R, George, Jacob, Bush, Brian J, Thacker, Leroy R, and Wong, Florence

Published
2023
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16. Quantitative MRI of chronic pancreatitis: results from a multi-institutional prospective study, magnetic resonance imaging as a non-invasive method for assessment of pancreatic fibrosis (MINIMAP)

Author

Tirkes, Temel, Yadav, Dhiraj, Conwell, Darwin L., Territo, Paul R., Zhao, Xuandong, Persohn, Scott A., Dasyam, Anil K., Shah, Zarine K., Venkatesh, Sudhakar K., Takahashi, Naoki, Wachsman, Ashley, Li, Liang, Li, Yan, Pandol, Stephen J., Park, Walter G., Vege, Santhi S., Hart, Phil A., Topazian, Mark, Andersen, Dana K., and Fogel, Evan L.

Published
2022
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19. T1 signal intensity ratio of the pancreas as an imaging biomarker for the staging of chronic pancreatitis

Author

Tirkes, Temel, Dasyam, Anil K., Shah, Zarine K., Fogel, Evan L., Vege, Santhi Swaroop, Li, Liang, Li, Shuang, Chang, Stephanie T., Farinas, Carlos A., Grajo, Joseph R., Mawad, Kareem, Takahashi, Naoki, Venkatesh, Sudhakar K., Wachsman, Ashley, Fisher, William E., Forsmark, Christopher E., Hart, Phil A., Pandol, Stephen J., Park, Walter G., Van Den Eeden, Stephen K., Yang, Yunlong, Topazian, Mark, Andersen, Dana K., Serrano, Jose, Conwell, Darwin L., and Yadav, Dhiraj

Published
2022
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20. Magnetic resonance imaging as a non-invasive method for the assessment of pancreatic fibrosis (MINIMAP): a comprehensive study design from the consortium for the study of chronic pancreatitis, diabetes, and pancreatic cancer

Author

Tirkes, Temel, Yadav, Dhiraj, Conwell, Darwin L, Territo, Paul R, Zhao, Xuandong, Venkatesh, Sudhakar K, Kolipaka, Arunark, Li, Liang, Pisegna, Joseph R, Pandol, Stephen J, Park, Walter G, Topazian, Mark, Serrano, Jose, and Fogel, Evan L

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Rare Diseases, Bioengineering, Biomedical Imaging, Cancer, Clinical Research, Digestive Diseases, Pancreatic Cancer, 4.2 Evaluation of markers and technologies, 4.1 Discovery and preclinical testing of markers and technologies, Detection, screening and diagnosis, Oral and gastrointestinal, Chronic Disease, Fibrosis, Humans, Magnetic Resonance Imaging, Multicenter Studies as Topic, Pancreatitis, United States, Chronic pancreatitis, MRI, MRCP, T-1 mapping, Extracellular volume, Diffusion-weighted imaging, MR elastography, Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer, T 1 mapping, Nuclear Medicine & Medical Imaging, Clinical sciences
Abstract

Characteristic features of chronic pancreatitis (CP) may be absent on standard imaging studies. Quantitative Magnetic Resonance Imaging (MRI) techniques such as T1 mapping, extracellular volume (ECV) fraction, diffusion-weighted imaging (DWI) with apparent diffusion coefficient map (ADC), MR elastography (MRE), and T1-weighted signal intensity ratio (SIR) have shown promise for the diagnosis and grading severity of CP. However, radiologists still use the Cambridge classification which is based on traditional ductal imaging alone. There is an urgent need to develop new diagnostic criteria that incorporate both parenchymal and ductal features of CP seen by MRI/MRCP. Designed to fulfill this clinical need, we present the MINIMAP study, which was funded in September 2018 by the National Institutes of Health. This is a comprehensive quantitative MR imaging study which will be performed at multiple institutions in well-phenotyped CP patient cohorts. We hypothesize that quantitative MRI/MRCP features can serve as valuable non-invasive imaging biomarkers to detect and grade CP. We will evaluate the role of T1 relaxometry, ECV, T1-weighted gradient echo SIR, MRE, arteriovenous enhancement ratio, ADC, pancreas volume/atrophy, pancreatic fat fraction, ductal features, and pancreatic exocrine output following secretin stimulation in the assessment of CP. We will attempt to generate a multi-parametric pancreatic tissue fibrosis (PTF) scoring system. We anticipate that a quantitative scoring system may serve as a biomarker of pancreatic fibrosis; hence this imaging technique can be used in clinical practice as well as clinical trials to evaluate the efficacy of agents which may slow the progression or reverse measures of CP.

Published
2019

21. Prospective Study Assessing Impact of Ethylene Oxide Sterilization on Endoscopic Ultrasound Image Quality

Author

Majumder, Shounak, Long, Zaiyang, Hooke, Alexander W., Petersen, Bret T., Gleeson, Ferga C., Bruno, Marco, DeWitt, John, Elta, Grace, Fuji, Larissa, Gomez, Victoria, Palazzo, Laurent, Shami, Vanessa M., Stevens, Tyler, Topazian, Mark D., Wiersema, Maurits J., Berglund, Lawrence J., Abu Dayyeh, Barham K., Chandrasekhara, Vinay, Iyer, Prasad G., Rajan, Elizabeth, Storm, Andrew C., Wang, Kenneth K., Lennon, Ryan, Larson, Joseph J., Enders, Felicity T., Frein, Jed R., Yates, Raymond A., Hangiandreou, Nicholas J., and Levy, Michael J.

Published
2022
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24. Diagnosis and treatment of exocrine pancreatic insufficiency in chronic pancreatitis: An international expert survey and case vignette study

Author

Falconi, Massimo, Zou, Wen-Bin, Engjom, Trond, Ooi, Chee Y., Sutton, Robert, Frulloni, Luca, Neoptolemos, John, Wilcox, Charles, Miroslav, Vujasinovic, Trikudanathan, Guru, Liao, Zhuan, Hauge, Truls, Mössner, Joachim, Hoge, Chantal, Fockens, Paul, Mieog, Sven, Capurso, Gabriele, Cui, Yunfeng, de Madaria, Enrique, Distler, Marius, Aghdassi, Ali, Whitcomb, David C., Russell, Kylie, Beyer, Georg, Kunovsky, Lumír, Kwanten, Wilhelmus, Nava, Andrea Kazemi, Conlon, Kevin, Siriwardena, A.K., Paiella, Salvatore, Alconchel, Felipe, Marino, Marco Vito, de Meijer, Vincent E., Domingo, Carlos, Kleeff, Jorg, Lakshmanan, Aarti, Lie Chu, Michael Jen, Bouwense, Stefan, Nashidengo, Pueya Rashid, Konstantinos, Perivoliotis, Muttillo, Edoardo Maria, Umar, Garzali Ibrahim, Castro Santiago, Maria Jesus, Lopez-Lopez, Victor, Torri, Francesco, Schmelzle, Moritz, Ignatavicius, Povilas, Wicherts, Dennis, Gomes, Antonio, Machairas, Nikolaos A., Dorovinis, Panagiotis I., Serrablo, Alejandro, Soreide, Kjetil, Rahbari, Mohammad, Jie Chu, Michael Jen, Ptasnuka, Margarita, Petrulionis, Marius, Noel, Colin Byron, Castro, Ernest, Di Martino, Marcello, Recordare, Alfonso, Stättner, Stefan, Ausania, Fabio, Hartman, Vera, Roeyen, Geert, Egorov, Viacheslav, Vanagas, Tomas, Ebrahim, Mohamed, Arabadzhieva, Elena, Malleo, Giuseppe, Li, Liang, Adams, David, Oracz, Grzegorz, Nageshwar, Reddy D., Waldthaler, Alexander, Masamune, Atsushi, Drewes, Asbjorn Mohr, Amodio, Antonio, Tirkes, Temel, Srivastava, Anshu, Beilman, Gregory J., Berger, Zoltan, Lindkvist, Bjorn, Cavestro, Giulia Martina, Gariepy, Cheryl, Czakó, Laszlo, Di Leo, Milena, Sharma, Vishal, Lakhtakia, Sundeep, Rana, Surinder Singh, Duggan, Sinaed N., Kwon, Chang-Il, Phillips, Anna Evans, Forsmark, Christopher E., Gleeson, Ferga C., Lehman, Glen A., Greenhalf, William, Costamagna, Guido, Halloran, Christopher M., Friess, Helmut, Rasmussen, Henrik Hojgaard, Ikeura, Tsukasa, Haldorsen, Ingfrid S., Itoi, Takao, Izbicki, Jacob R., Windsor, John, Poulsen, Jakob Lykke, Frokjaer, Jens Brondum, Larino-Noia, Jose, Wang, Dan, Garcia, Julio Iglesias, Kalaitzakis, Evangelos, Wertheim-Tysarowska, Kararzyna, Kubota, Kensuke, Larusch, Jessica, Lerch, Markus M., Hu, Liang-Hao, Erkan, Mert, Machicado, Jorg D., Arvanitakis, Marianna, Buchler, Markus W., Levy, Marlon F., Heyman, Melvin B., Nojgaard, Camilla, Khashab, Mouen A., Delhaye, Myriam, Ogura, Takeshi, Okazaki, Kazuichi, Ghaneh, Paula, Banks, Peter A., Gupta, Pankaj, Papachristou, Georgios I., Michl, Patrick, Levy, Philippe, Pukitis, Aldis, Pezzilli, Raffaele, Baron, Ryan D., Amann, Stephen T., Schwarzenberg, Sarah Jane, Isaji, Shuiji, Olesen, Soren Schou, Novovic, Srdan, Hughes, Steven J., Werlin, Steven L., Gonska, Tanja, Gardner, Timothy B., Topazian, Mark D., Weiss, Frank Ulrich, Akshintala, Venakata S., Morinville, Veronique D., Rebours, Vinciane, Vincze, Aron, Singh, Vikesh K., Cui, Naiqiang, Zhang, Hong, Li, Zhao-shen, de Rijk, Florence E.M., van Veldhuisen, Charlotte L., Besselink, Marc G., van Hooft, Jeanin E., van Santvoort, Hjalmar C., van Geenen, Erwin J.M., Hegyi, Peter, Löhr, J-Matthias, Dominguez-Munoz, Juan E., de Jonge, Pieter Jan F., Bruno, Marco J., and Verdonk, Robert C.

Published
2022
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26. Combined Drainage and Protocolized Necrosectomy Through a Coaxial Lumen-apposing Metal Stent for Pancreatic Walled-off Necrosis: A Prospective Multicenter Trial

Author

Dayyeh, Barham K. Abu, Chandrasekhara, Vinay, Shah, Raj J., Easler, Jeffrey J., Storm, Andrew C., Topazian, Mark, Levy, Michael J., Martin, John A., Petersen, Bret T., Takahashi, Naoki, Edmundowicz, Steven, Hammad, Hazem, Wagh, Mihir S., Wani, Sachin, DeWitt, John, Bick, Benjamin, Gromski, Mark, Al Haddad, Mohammad, Sherman, Stuart, Merchant, Ambreen A., Peetermans, Joyce A., Gjata, Ornela, McMullen, Edmund, and Willingham, Field F.

Published
2023
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27. Standard Operating Procedures for Biospecimen Collection, Processing, and Storage

Author

Fisher, William E, Cruz-Monserrate, Zobeida, McElhany, Amy L, Lesinski, Gregory B, Hart, Phil A, Ghosh, Ria, Van Buren, George, Fishman, Douglas S, Rinaudo, Jo Ann S, Serrano, Jose, Srivastava, Sudhir, Mace, Thomas, Topazian, Mark, Feng, Ziding, Yadav, Dhiraj, Pandol, Stephen J, Hughes, Steven J, Liu, Robert Y, Lu, Emily, Orr, Robert, Whitcomb, David C, Abouhamze, Amer S, Steen, Hanno, Sellers, Zachary M, Troendle, David M, Uc, Aliye, Lowe, Mark E, and Conwell, Darwin L

Subjects
Digestive Diseases, Cancer, Rare Diseases, Clinical Research, Diabetes, Pancreatic Cancer, Metabolic and endocrine, Biological Specimen Banks, Biomedical Research, Child, Diabetes Mellitus, Guidelines as Topic, Humans, Pancreatic Neoplasms, Pancreatitis, Chronic, Preservation, Biological, Specimen Handling, biorepository, biospecimens, pancreas, standard operating procedures, Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer, Clinical Sciences, Gastroenterology & Hepatology
Abstract

High-quality and well-annotated biorepositories are needed to better understand the pathophysiology and biologic mechanisms of chronic pancreatitis (CP) and its consequences. We report a methodology for the development of a robust standard operating procedure (SOP) for a biorepository based on the experience of the clinical centers within the consortium to study Chronic Pancreatitis, Diabetes and Pancreas Cancer Clinical Centers (CPDPC), supported by the National Cancer Institute and the National Institute for Diabetes and Digestive and Kidney Diseases as a unique multidisciplinary model to study CP, diabetes, and pancreatic cancer in both children and adults. Standard operating procedures from the CPDPC centers were evaluated and consolidated. The literature was reviewed for standard biorepository operating procedures that facilitated downstream molecular analysis. The existing literature on biobanking practices was harmonized with the SOPs from the clinical centers to produce a biorepository for pancreatic research. This article reports the methods and basic principles behind the creation of SOPs to develop a biorepository for the CPDPC. These will serve as a guide for investigators developing biorepositories in pancreas research. Rigorous and meticulous adherence to standardized biospecimen collection will facilitate investigations to better understand the pathophysiology and biologic mechanisms of CP, diabetes, and pancreatic cancer.

Published
2018

28. PROspective Evaluation of Chronic Pancreatitis for EpidEmiologic and Translational StuDies

Author

Yadav, Dhiraj, Park, Walter G, Fogel, Evan L, Li, Liang, Chari, Suresh T, Feng, Ziding, Fisher, William E, Forsmark, Christopher E, Jeon, Christie Y, Habtezion, Aida, Hart, Phil A, Hughes, Steven J, Othman, Mohamed O, Rinaudo, Jo Ann S, Pandol, Stephen J, Tirkes, Temel, Serrano, Jose, Srivastava, Sudhir, Van Den Eeden, Stephen K, Whitcomb, David C, Topazian, Mark, and Conwell, Darwin L

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Pancreatic Cancer, Prevention, Digestive Diseases, Rare Diseases, Cancer, Clinical Research, 2.1 Biological and endogenous factors, 4.2 Evaluation of markers and technologies, Detection, screening and diagnosis, Aetiology, Oral and gastrointestinal, Adult, Biomarkers, Blood Specimen Collection, Diabetes Mellitus, Disease Progression, Humans, Longitudinal Studies, Observational Studies as Topic, Outcome Assessment, Health Care, Pancreatic Neoplasms, Pancreatitis, Chronic, Prospective Studies, Research Design, Specimen Handling, Translational Research, Biomedical, United States, pancreas, alcohol, tobacco, genetic, biorepository, cohort, Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer, Gastroenterology & Hepatology, Clinical sciences
Abstract

Prospective Evaluation of Chronic Pancreatitis for Epidemiologic and Translational Studies (PROCEED) is the first prospective, observational cohort study of chronic pancreatitis (CP) in the United States. The primary goals of PROCEED are to define disease progression, test the predictive capability of candidate biomarkers, and develop a platform to conduct translational and mechanistic studies in CP. Using objective and consensus-driven criteria, PROCEED will enroll adults at different stages of CP-controls, suspected CP, and definite CP. In addition to collecting detailed information using structured case report forms and protocol-mandated evaluations at baseline and during follow-up, PROCEED will establish a linked biorepository of blood, urine, saliva, stool, pancreatic fluid, and pancreatic tissue. Enrollment for PROCEED began in June 2017. As of July 1, 2018, nine clinical centers of the Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer are enrolling, and 350 subjects have completed baseline evaluation. In conclusion, PROCEED will provide the most accurate and reliable estimates to date on progression of CP. The established cohort and biorepository will facilitate numerous analyses, leading to new strategies for diagnosis, methods to monitor disease progression, and treatment of CP.

Published
2018

29. FRI-088 Patterns and predictors of postacute discharge location other than home in a global cohort of 3, 678 patients hospitalized with cirrhosis

Author

Seto, Wai-Kay, primary, Xie, Qing, additional, Kumar Choudhury, Ashok, additional, Kamath, Patrick S., additional, Topazian, Mark, additional, Hayes, Peter, additional, Torre, Aldo, additional, Desalegn, Hailemichael, additional, Idilman, Ramazan, additional, Cao, Zhujun, additional, Álvares-da-Silva, Mario, additional, George, Jacob, additional, Wong, Florence, additional, Bush, Brian, additional, Thacker, Leroy, additional, Kumar Sarin, Shiv, additional, Mani, Iliana, additional, Dincer, Dinc, additional, van Doorn, Diederick, additional, Sonavane, Amey, additional, Amin Fallahzadeh, Mohammad, additional, Wei, Linlin, additional, Bravo Cabrera, Araceli, additional, Goel, Ashish, additional, Ponan Claude Regis Lah, Ponan, additional, Kumar, Shiva, additional, Jun Wong, Yu, additional, Jothimani, Dinesh, additional, Robert Kappus, Matthew, additional, Emre Yıldırım, Abdullah, additional, H Forrest, Ewan, additional, Félix Tellez, Francisco, additional, Momoyo Zitelli, Patricia, additional, Barbero, Manuel, additional, Luis Pérez-Hernández, José, additional, Marciano, Sebastián, additional, Malé Velazquez, René, additional, Jhaveri, Ajay, additional, Gibson, Robert, additional, Chandra Anand, Anil, additional, Kayes, Tahrima, additional, Gunduz, Feyza, additional, Bayne, David, additional, Lin, Minghua, additional, Ucbilek, Enver, additional, Debzi, Nabil, additional, Wang, Jian, additional, Haresh Kumar Patwa, Yashwi, additional, Kumar Duseja, Ajay, additional, Arrese, Marco, additional, Faulkes, Rosemary, additional, Kennedy, James, additional, Sung Kim, Yu, additional, Krishan Dhiman, Radha, additional, Li, Hai, additional, Yin, Dedong, additional, Zhang, Yanyun, additional, MacQuillan, Gerry, additional, Kumar, Ashish, additional, Katchman, Helena, additional, Wang, Yingling, additional, Rao, Qunfang, additional, Cai, Yijing, additional, Wu, Liyang, additional, Jiang, Yongfang, additional, Xu, Zhen, additional, Xian, Yongchao, additional, Bettinger, Dominik, additional, Dahiya, Monica, additional, Faisal, Nabiha, additional, Rojo Andres, Duarte, additional, Filipek, Natalia, additional, Tudehope, Fiona, additional, Zhang, Wanqin, additional, and Bajaj, Jasmohan, additional

Published
2024
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30. Diagnostic and Prognostic Biomarkers of Chronic Pancreatitis: A Conceptual Framework Based on the PRoBE Design

Author

Yadav, Dhiraj, primary, Conwell, Darwin L., additional, Pandol, Stephen J., additional, Steen, Hanno, additional, Feng, Ziding, additional, Li, Liang, additional, Andersen, Dana, additional, Bellin, Melena, additional, Chari, Suresh T., additional, Cruz-Monserrate, Zobeida, additional, Fisher, William E., additional, Fogel, Evan L., additional, Forsmark, Christopher E., additional, Hart, Phil A., additional, Lesinski, Gregory B., additional, Park, Walter G., additional, Rinaudo, Jo Ann, additional, Saloman, Jami L., additional, Serrano, Jose, additional, Tirkes, Temel, additional, Topazian, Mark D., additional, van Den Eeden, Stephen, additional, Vege, Santhi Swaroop, additional, and Whitcomb, David C., additional

Published
2024
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33. Characterizing mechanism-based pain phenotypes in patients with chronic pancreatitis: a cross-sectional analysis of the PROspective Evaluation of Chronic Pancreatitis for EpidEmiologic and Translational StuDies

Author

Saloman, Jami L., Conwell, Darwin L., Fogel, Evan, Vege, Santhi Swaroop, Li, Liang, Li, Shuang, Andersen, Dana K., Fisher, William E., Forsmark, Christopher E., Hart, Phil A., Pandol, Stephen J., Park, Walter G., Phillips, Anna Evans, Topazian, Mark, Van Den Eeden, Stephen K., Serrano, Jose, and Yadav, Dhiraj

Published
2023
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36. Endoscopic Ultrasound and Related Technologies for the Diagnosis and Treatment of Pancreatic Disease - Research Gaps and Opportunities

Author

Lee, Linda S, Andersen, Dana K, Ashida, Reiko, Brugge, William R, Canto, Mimi I, Chang, Kenneth J, Chari, Suresh T, DeWitt, John, Hwang, Joo Ha, Khashab, Mouen A, Kim, Kang, Levy, Michael J, McGrath, Kevin, Park, Walter G, Singhi, Aatur, Stevens, Tyler, Thompson, Christopher C, Topazian, Mark D, Wallace, Michael B, Wani, Sachin, Waxman, Irving, Yadav, Dhiraj, and Singh, Vikesh K

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Cancer, Biomedical Imaging, Rare Diseases, Digestive Diseases, Pancreatic Cancer, Biomedical Research, Diagnostic Techniques and Procedures, Endosonography, Humans, National Institute of Diabetes and Digestive and Kidney Diseases (U.S.), Pancreatic Diseases, Reproducibility of Results, Review Literature as Topic, Sensitivity and Specificity, United States, Gastroenterology & Hepatology, Clinical sciences
Abstract

A workshop was sponsored by the National Institute of Diabetes and Digestive and Kidney Diseases to address the research gaps and opportunities in pancreatic endoscopic ultrasound (EUS). The event occurred on July 26, 2017 in 4 sessions: (1) benign pancreatic diseases, (2) high-risk pancreatic diseases, (3) diagnostic and therapeutics, and (4) new technologies. The current state of knowledge was reviewed, with identification of numerous gaps in knowledge and research needs. Common themes included the need for large multicenter consortia of various pancreatic diseases to facilitate meaningful research of these entities; to standardize EUS features of different pancreatic disorders, the technique of sampling pancreatic lesions, and the performance of various therapeutic EUS procedures; and to identify high-risk disease early at the cellular level before macroscopic disease develops. The need for specialized tools and accessories to enable the safe and effective performance of therapeutic EUS procedures also was discussed.

Published
2017

37. EUS and related technologies for the diagnosis and treatment of pancreatic disease: research gaps and opportunities—Summary of a National Institute of Diabetes and Digestive and Kidney Diseases workshop

Author

Lee, Linda S, Andersen, Dana K, Ashida, Reiko, Brugge, William R, Canto, Mimi I, Chang, Kenneth J, Chari, Suresh T, DeWitt, John, Hwang, Joo Ha, Khashab, Mouen A, Kim, Kang, Levy, Michael J, McGrath, Kevin, Park, Walter G, Singhi, Aatur, Stevens, Tyler, Thompson, Christopher C, Topazian, Mark D, Wallace, Michael B, Wani, Sachin, Waxman, Irving, Yadav, Dhiraj, and Singh, Vikesh K

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Digestive Diseases, Diabetes, Pancreatic Cancer, Cancer, Rare Diseases, Good Health and Well Being, Autoimmune Diseases, Cancer Pain, Clinical Competence, Drainage, Endosonography, Humans, National Institute of Diabetes and Digestive and Kidney Diseases (U.S.), Nerve Block, Pancreatic Diseases, Pancreatic Neoplasms, Pancreatic Pseudocyst, Pancreatitis, United States, Gastroenterology & Hepatology, Clinical sciences
Abstract

A workshop was sponsored by the National Institute of Diabetes and Digestive and Kidney Diseases to address the research gaps and opportunities in pancreatic EUS. The event occurred on July 26, 2017 in 4 sessions: (1) benign pancreatic diseases, (2) high-risk pancreatic diseases, (3) diagnostic and therapeutics, and (4) new technologies. The current state of knowledge was reviewed, with identification of numerous gaps in knowledge and research needs. Common themes included the need for large multicenter consortia of various pancreatic diseases to facilitate meaningful research of these entities; to standardize EUS features of different pancreatic disorders, the technique of sampling pancreatic lesions, and the performance of various therapeutic EUS procedures; and to identify high-risk disease early at the cellular level before macroscopic disease develops. The need for specialized tools and accessories to enable the safe and effective performance of therapeutic EUS procedures also was discussed.

Published
2017

38. Global prevalence and characteristics of infections and clinical outcomes in hospitalised patients with cirrhosis: a prospective cohort study for the CLEARED Consortium

Author

Cao, Zhujun, Wong, Florence, Choudhury, Ashok K, Kamath, Patrick S, Topazian, Mark, Torre, Aldo, Hayes, Peter C, George, Jacob, Idilman, Ramazan, Seto, Wai-Kay, Desalegn, Hailemichael, Alvares-da-Silva, Mario Reis, Bush, Brian J, Thacker, Leroy R, Xie, Qing, Bajaj, Jasmohan S, Kumar, Shiva, Gadano, Adrián, Marciano, Sebastián, Tudehope, Fiona, Prudence, Alexander, Gibson, Robert, Zekry, Amany, Doyle, Adam, Si, Hooi Ling, Kim, Yu Sung, Gofton, Cameron, Riordan, Stephen, MacQuillan, Gerry, Al-Tamimi, Hala, Michalczuk, Matheus, Farias, Alberto, Zitelli, Patricia, Pereira, Gustavo, Victor, Livia, Bera, Chinmay, Faisal, Nabiha, Dahiya, Monica, Tandon, Puneeta, Lohoues, Marie Jeanne, Lah, Ponan Claude Regis, Benítez, Carlos, Arrese, Marco, Guan, Jing, Xian, Yongchao, Zhu, Chuanwu, Wang, Yingling, Su, Man, Su, Minghua, Wang, Xinrui, Gao, Yanhang, Peng, Feng, Jiang, Yongfang, Zhao, Caiyan, Wang, Wei, Yin, Dedong, Wang, Lei, Lu, Mingqin, Cai, Yijing, Guo, Feng, Wang, Xiaozhong, Zhang, Ningping, Zhang, Wanqin, Dong, Fuchen, Li, Hai, Liu, Jing, Zheng, Xin, Tang, Hong, Yan, Libo, Xu, Bin, Wei, Linlin, Xu, Zhen, Gao, Zhiliang, Gao, Haibing, Lin, Minghua, Rao, Qunfang, Wu, Xiaoping, Li, Beiling, Chen, Jinjun, Liu, Chenghai, Zhang, Yanyun, Deng, Huan, Hu, Peng, Wang, Jian, Li, Jie, Bettinger, Dominik, Schultheiß, Michael, Belimi, Hibat Allah, Debzi, Nabil, Mostafa, Alaa, Fouad, Yasser, Fisseha, Henok, Venkatachalapathy, Suresh Vasan, Aravinthan, Aloysious D, Rajoriya, Neil, Faulkes, Rosemary, Leith, Damien, Forrest, Ewan, Danielle, Adebayo, Kennedy, James, Yung, Diana, Alexopoulou, Alexandra, Mani, Iliana, Fung, James, Katchman, Helena, Rabinowich, Liane, Jhaveri, Ajay, Nagral, Aabha, Kulkarni, Anand, Sharma, Mithun, Sarin, Shiv K, Goel, Ashish, Eapen, C E, Duseja, Ajay, Gandotra, Akash, Saraya, Anoop, yegurla, Jatin, Jothimani, Dinesh, Rela, Mohammad, Arora, Anil, Kumar, Ashish, Roy, Akash, Dhiman, R K, Anand, A C, Praharaj, Dibyalochan, Cabrera, Araceli Bravo, Hueso, Sarai Gonzalez, Hérnandez, José Luis Pérez, Gutierrez, Oscar Morales, Ramos-Pineda, Abraham, Zazueta, Godolfino Miranda, Barradas, Mauricio Castillo, Made, Lilian Torres, Velazquez, Rene Male, Félix-Tellez, Francisco, Velasco, José Antonio Velarde-Ruiz, Cordova-Gallardo, Jacqueline, Rajaram, Ruveena, Afendi, Nik Arsyad Nik Muhamad, Nyam, David P, Okeke, Edith N, Allam, Dalia, Patwa, Yashwi Haresh Kumar, Tan, Hiang Keat, Lun, Liou Wei, Ho, Wei Ling Danielle, Wong, Yu Jun, Thanapirom, Kessarin, Teerasarntipan, Tongluk, Haktaniyan, Busra, Gunduz, Feyza, Aslan, Rahmi, Yildirim, Abdullah Emre, Barutcu, Sezgin, Uysal, Alper, Karasu, Zeki, Ucbilek, Enver, Kosay, Tolga, Dinçer, Dinç, Adanır, Haydar, Albhaisi, Somaya, Fallahadeh, Mohammad Amin, Asrani, Sumeet, Reddy, K Rajender, Shaw, Jawaid, Vargas, Hugo, Filipek, Natalia, Biggins, Scott W, Thuluvath, Paul, Sheshadri, Somya, Wegermann, Kara, Kappus, Matthew, Keaveny, Andrew, Rojo, Andres, Negrillo, Ricardo Cabello, and Verna, Elizabeth

Abstract

Infections have a poor prognosis in inpatients with cirrhosis. We aimed to determine regional variations in infections and their association with clinical outcomes in a global cohort of inpatients with cirrhosis.

Published
2024
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39. Biomarkers of Chronic Pancreatitis: A systematic literature review

Author

Cruz-Monserrate, Zobeida, Gumpper, Kristyn, Pita, Valentina, Hart, Phil A., Forsmark, Christopher, Whitcomb, David C., Yadav, Dhiraj, Waldron, Richard T., Pandol, Stephen, Steen, Hanno, Anani, Vincent, Kanwar, Natasha, Vege, Santhi Swaroop, Appana, Savi, Li, Liang, Serrano, Jose, Rinaudo, Jo Ann S., Topazian, Mark, and Conwell, Darwin L.

Published
2021
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40. Characterizing mechanism-based pain phenotypes in patients with chronic pancreatitis: a cross-sectional analysis of the PROCEED study.

Author

Saloman, Jami L., Conwell, Darwin L., Fogel, Evan, Vege, Santhi Swaroop, Li, Liang, Li, Shuang, Andersen, Dana K., Fisher, William E., Forsmark, Christopher E., Hart, Phil A., Pandol, Stephen J., Park, Walter G., Phillips, Anna Evans, Topazian, Mark, Van Den Eeden, Stephen K., Serrano, Jose, and Yadav, Dhiraj

Published
2022
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41. Coaxial plastic stent placement within lumen-apposing metal stents for the management of pancreatic fluid collections: a systemic review and meta-analysis.

Author

AbiMansour, Jad, Jaruvongvanich, Veeravich, Velaga, Saran, Law, Ryan, Storm, Andrew C., Topazian, Mark, Levy, Michael J., Alexander, Ryan, Vargas, Eric J., Bofill-Garica, Aliana, Martin, John A., Petersen, Bret T., Dayyeh, Barham K. Abu, and Chandrasekhara, Vinay

Subjects
CHRONIC pancreatitis, NECROTIZING pancreatitis, ENDOSCOPIC ultrasonography, MEDICAL drainage, ODDS ratio
Abstract

Background/Aims: Coaxial placement of double pigtail plastic stents (DPPS) through lumen-apposing metal stents (LAMSs) is commonly performed to reduce the risk of LAMS obstruction, bleeding, and stent migration when used for the drainage of pancreatic fluid collections (PFCs). A systematic review and meta-analysis were performed to compare the outcomes of LAMS alone and LAMS with coaxial DPPS placement in the management of PFCs. Methods: A systematic review was conducted to identify studies comparing LAMS and LAMS/DPPS for PFC drainage. Primary outcomes included the rate of clinical success, overall adverse events (AEs), bleeding, infection, occlusion, and stent migration. The pooled effect size was summarized using a random-effects model and compared between LAMS and LAMS/DPPS by calculating odds ratios (ORs). Results: Nine studies involving 709 patients were identified (338 on LAMS and 371 on LAMS/DPPS). LAMS/DPPS was associated with a reduced risk of stent obstruction (OR, 0.59; p=0.004) and infection (OR, 0.55; p=0.001). No significant differences were observed in clinical success (OR, 0.96; p=0.440), overall AEs (OR, 0.57; p=0.060), bleeding (OR, 0.61; p=0.120), or stent migration (OR, 1.03; p=0.480). Conclusions: Coaxial DPPS for LAMS drainage of PFCs is associated with a reduced risk of stent occlusion and infection; however, no difference was observed in the overall AE rates or bleeding. [ABSTRACT FROM AUTHOR]

Published
2024
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46. Methylated DNA in Pancreatic Juice Distinguishes Patients With Pancreatic Cancer From Controls

Author

Majumder, Shounak, Raimondo, Massimo, Taylor, William R., Yab, Tracy C., Berger, Calise K., Dukek, Brian A., Cao, Xiaoming, Foote, Patrick H., Wu, Chung Wah, Devens, Mary E., Mahoney, Douglas W., Smyrk, Thomas C., Pannala, Rahul, Chari, Suresh T., Vege, Santhi Swaroop, Topazian, Mark D., Petersen, Bret T., Levy, Michael J., Rajan, Elizabeth, Gleeson, Ferga C., Abu Dayyeh, Barham, Nguyen, Cuong C., Faigel, Douglas O., Woodward, Timothy A., Wallace, Michael B., Petersen, Gloria, Allawi, Hatim T., Lidgard, Graham P., Kisiel, John B., and Ahlquist, David A.

Published
2020
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49. Clinical impact of celiac ganglia metastasis upon pancreatic ductal adenocarcinoma

Author

Malikowski, Thomas, Lehrke, Heidi D., Henry, Michael R., Gleeson, Ferga C., Alberts, Steven R., Kendrick, Michael L., Lennon, Ryan J., McWilliams, Robert R., Takahashi, Naoki, Topazian, Mark D., Gara, Naveen, Abu Dayyeh, Barham K., Chandrasekhara, Vinay, Chari, Suresh T., Iyer, Prasad G., Rajan, Elizabeth, Storm, Andrew C., Wang, Kenneth K., and Levy, Michael J.

Published
2020
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