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3. Safety and efficacy of subcutaneous iscalimab (CFZ533) in two distinct populations of patients with Sjögren's disease (TWINSS): week 24 results of a randomised, double-blind, placebo-controlled, phase 2b dose-ranging study

Author

Maid, Pablo, Rillo, Oscar, Inderjeeth, Charles, Scheinecker, Clemens, Hermann, Josef, Marcolino, Flora Maria D'Andrea, Dias, Laiza H, Scafuto, Antonio, Bookman, Arthur AM, Fortin, Isabelle, Morin, Frederic, Goio, Elizabeth Jean Moreno, Pezo Ruiz, Ninette, Roman Zamoran, Carlos Patricio, Gonzalez Abarzua, Ivan Antonio, Elgueta, Sergio Fabian, Forero Illera, Elias Gonzalo, Marquez Herndez, Javier Dario, Garcia, Alex Echeverri, Pensec, Valerie Devauchelle, Hachulla, Eric, Mariette, Xavier, Gottenberg, Jacques-Eric, Le Guern, Veronique, Finzel, Stephanie, Schaefer, Valentin, Tony, Hans-Peter, Thomas Schmalzing, Marc, Tausche-Wunderlich, Anne-Kathrin, Tzioufas, Athanasios, Balog, Attila, Rojkovich, Bernadette, Varga, Tunde, Lidar, Merav, Rosner, Itzhak, Levy, Yair, Dagna, Lorenzo, Mosca, Marta, Quartuccio, Luca, Nishiyama, Susumu, Kodera, Masanari, Kaneko, Yuko, Okada, Masato, Ueki, Yukitaka, Hwan Park, Sung, van Daele, Paulus Leon Arthur, Bootsma, Hendrika, Duarte Barcelos, Filipe Alexandre, Crispim Romao, Vasco Madeira, Raimundo Vinagre, Filipe Manuel, Tavaresda Costa, Jose Antonio, Rednic, Simona, Duca, Liliana, Maslyanskiy, Alexey, Yakupova, Svetlana, Bugrova, Olga, Izmozherova, Nadezhda, Zotkin, Evgenyi, Nikolaevna Anoshenkova, Olga, Kvarnstrom, Marika, Tufan, Abdurrahman, Fisher, Benjamin, Yee, Chee Seng, Parker, Benjamin Joseph, Grader Beck, Thomas, Lawrence Ford, Theresa, Papas, Athena, Carsons, Steven, Thiagarajan, Saravanan, Zero, Domenick, McCoy, Sara, Sandorfi, Nora, Fisher, Benjamin A, Grader-Beck, Thomas, Ng, Wan-Fai, van Daele, P L A, Noaiseh, Ghaith, Elgueta, Sergio, McCoy, Sara S, Akpek, Esen, Bookman, Arthur, Sopala, Monika, Montecchi-Palmer, Michela, Luo, Wen-Lin, Scheurer, Cornelia, and Hueber, Wolfgang

Published
2024
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5. The efficacy and safety of systemic corticosteroids as first line treatment for granulomatous lymphocytic interstitial lung disease

Author

Smits, Bas, Goldacker, Sigune, Seneviratne, Suranjith, Malphettes, Marion, Longhurst, Hilary, Mohamed, Omar E., Witt-Rautenberg, Carla, Leeman, Lucy, Schwaneck, Eva, Raymond, Isabelle, Meghit, Kilifa, Uhlmann, Annette, Winterhalter, Christine, van Montfrans, Joris, Klima, Marion, Workman, Sarita, Fieschi, Claire, Lorenzo, Lorena, Boyle, Sonja, Onyango-Odera, Shamin, Price, Suzanne, Schmalzing, Marc, Aurillac, Valerie, Prasse, Antje, Hartmann, Ieneke, Meerburg, Jennifer J., Kemner-van de Corput, Mariette, Tiddens, Harm, Grimbacher, Bodo, Kelleher, Peter, Patel, Smita Y., Korganow, Anne-Sophie, Viallard, Jean-Francois, Tony, Hans-Peter, Bethune, Claire, Schulze-Koops, Hendrik, Witte, Torsten, Huissoon, Aarnoud, Baxendale, Helen, Grigoriadou, Sofia, Oksenhendler, Eric, Burns, Siobhan O., and Warnatz, Klaus

Published
2023
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6. Safety and efficacy of secukinumab in patients with giant cell arteritis (TitAIN): a randomised, double-blind, placebo-controlled, phase 2 trial

Author

Venhoff, Nils, Schmidt, Wolfgang A, Bergner, Raoul, Rech, Jürgen, Unger, Leonore, Tony, Hans-Peter, Finzel, Stephanie, Andreica, Ioana, Kofler, David M, Weiner, Stefan M, Lamprecht, Peter, Schulze-Koops, Hendrik, App, Christine, Pournara, Effie, Mendelson, Meryl H, Sieder, Christian, Maricos, Meron, and Thiel, Jens

Published
2023
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10. Treatment tapering and stopping in patients with rheumatoid arthritis in stable remission (RETRO): a multicentre, randomised, controlled, open-label, phase 3 trial

Author

Tascilar, Koray, Hagen, Melanie, Kleyer, Arnd, Simon, David, Reiser, Michaela, Hueber, Axel J, Manger, Bernhard, Englbrecht, Matthias, Finzel, Stephanie, Tony, Hans-Peter, Schuch, Florian, Kleinert, Stefan, Wendler, Joerg, Ronneberger, Monika, Figueiredo, Camille P, Cobra, Jayme F, Feuchtenberger, Martin, Fleck, Martin, Manger, Karin, Ochs, Wolfgang, Schmitt-Haendle, Matthias, Lorenz, Hanns-Martin, Nuesslein, Hubert, Alten, Rieke, Kruger, Klaus, Henes, Joerg, Schett, Georg, and Rech, Juergen

Published
2021
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15. Safety and efficacy of subcutaneous iscalimab (CFZ533) in two distinct populations of patients with Sjögren's disease (TWINSS): week 24 results of a randomised, double-blind, placebo-controlled, phase 2b dose-ranging study

Author

Fisher, Benjamin A, Mariette, Xavier, Papas, Athena, Grader-Beck, Thomas, Bootsma, Hendrika, Ng, Wan-Fai, van Daele, P L A, Finzel, Stephanie, Noaiseh, Ghaith, Elgueta, Sergio, Hermann, Josef, McCoy, Sara S, Akpek, Esen, Bookman, Arthur, Sopala, Monika, Montecchi-Palmer, Michela, Luo, Wen-Lin, Scheurer, Cornelia, Hueber, Wolfgang, Maid, Pablo, Rillo, Oscar, Inderjeeth, Charles, Scheinecker, Clemens, Hermann, Josef, Marcolino, Flora Maria D'Andrea, Dias, Laiza H, Scafuto, Antonio, Bookman, Arthur AM, Fortin, Isabelle, Morin, Frederic, Goio, Elizabeth Jean Moreno, Pezo Ruiz, Ninette, Roman Zamoran, Carlos Patricio, Gonzalez Abarzua, Ivan Antonio, Elgueta, Sergio Fabian, Forero Illera, Elias Gonzalo, Marquez Herndez, Javier Dario, Garcia, Alex Echeverri, Pensec, Valerie Devauchelle, Hachulla, Eric, Mariette, Xavier, Gottenberg, Jacques-Eric, Le Guern, Veronique, Finzel, Stephanie, Schaefer, Valentin, Tony, Hans-Peter, Thomas Schmalzing, Marc, Tausche-Wunderlich, Anne-Kathrin, Tzioufas, Athanasios, Balog, Attila, Rojkovich, Bernadette, Varga, Tunde, Lidar, Merav, Rosner, Itzhak, Levy, Yair, Dagna, Lorenzo, Mosca, Marta, Quartuccio, Luca, Nishiyama, Susumu, Kodera, Masanari, Kaneko, Yuko, Okada, Masato, Ueki, Yukitaka, Hwan Park, Sung, van Daele, Paulus Leon Arthur, Bootsma, Hendrika, Duarte Barcelos, Filipe Alexandre, Crispim Romao, Vasco Madeira, Raimundo Vinagre, Filipe Manuel, Tavaresda Costa, Jose Antonio, Rednic, Simona, Duca, Liliana, Maslyanskiy, Alexey, Yakupova, Svetlana, Bugrova, Olga, Izmozherova, Nadezhda, Zotkin, Evgenyi, Nikolaevna Anoshenkova, Olga, Kvarnstrom, Marika, Tufan, Abdurrahman, Fisher, Benjamin, Yee, Chee Seng, Parker, Benjamin Joseph, Grader Beck, Thomas, Lawrence Ford, Theresa, Papas, Athena, Carsons, Steven, Thiagarajan, Saravanan, Zero, Domenick, McCoy, Sara, and Sandorfi, Nora

Abstract

Sjögren's disease is a chronic autoimmune disease with an unmet need for targeted therapies. The aim of the TWINSS study is to evaluate the safety and efficacy of iscalimab, a monoclonal antibody against CD40, in patients with active Sjögren's disease.

Published
2024
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18. Erratum zu: Apps in der Rheumatologie

Author

Strunz, Patrick-Pascal, Maire, Maxime Le, Heusinger, Tobias, Hammel, Ludwig, Gernert, Michael, Schwaneck, Eva C., Callhoff, Johanna, Portegys, Jan, Schmalzing, Marc, Tony, Hans-Peter, and Froehlich, Matthias

Published
2021
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23. Physical Function of RA patients Tapering Treatment—A Post Hoc Analysis of the Randomized Controlled RETRO Trial

Author

Stephan, Marlene, primary, Tascilar, Koray, additional, Yalcin-Mutlu, Melek, additional, Hagen, Melanie, additional, Haschka, Judith, additional, Reiser, Michaela, additional, Hartmann, Fabian, additional, Kleyer, Arnd, additional, Hueber, Axel J., additional, Manger, Bernhard, additional, Figueiredo, Camille, additional, Cobra, Jayme Fogagnolo, additional, Tony, Hans-Peter, additional, Finzel, Stephanie, additional, Kleinert, Stefan, additional, Wendler, Jörg, additional, Schuch, Florian, additional, Ronneberger, Monika, additional, Feuchtenberger, Martin, additional, Fleck, Martin, additional, Manger, Karin, additional, Ochs, Wolfgang, additional, Schmitt-Haendle, Matthias, additional, Lorenz, Hannes Martin, additional, Nüsslein, Hubert, additional, Alten, Rieke, additional, Henes, Joerg, additional, Krüger, Klaus, additional, Schett, Georg, additional, and Rech, Jürgen, additional

Published
2023
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24. The efficacy and safety of systemic corticosteroids as first line treatment for granulomatous lymphocytic interstitial lung disease

Author

Immuno/reuma onderzoek 1 (Vastert), Cluster B, Immuno/reuma patientenzorg, Child Health, Infection & Immunity, Smits, Bas, Goldacker, Sigune, Seneviratne, Suranjith, Malphettes, Marion, Longhurst, Hilary, Mohamed, Omar E., Witt-Rautenberg, Carla, Leeman, Lucy, Schwaneck, Eva, Raymond, Isabelle, Meghit, Kilifa, Uhlmann, Annette, Winterhalter, Christine, van Montfrans, Joris, Klima, Marion, Workman, Sarita, Fieschi, Claire, Lorenzo, Lorena, Boyle, Sonja, Onyango-Odera, Shamin, Price, Suzanne, Schmalzing, Marc, Aurillac, Valerie, Prasse, Antje, Hartmann, Ieneke, Meerburg, Jennifer J., Kemner-van de Corput, Mariette, Tiddens, Harm, Grimbacher, Bodo, Kelleher, Peter, Patel, Smita Y., Korganow, Anne Sophie, Viallard, Jean Francois, Tony, Hans Peter, Bethune, Claire, Schulze-Koops, Hendrik, Witte, Torsten, Huissoon, Aarnoud, Baxendale, Helen, Grigoriadou, Sofia, Oksenhendler, Eric, Burns, Siobhan O., Warnatz, Klaus, Immuno/reuma onderzoek 1 (Vastert), Cluster B, Immuno/reuma patientenzorg, Child Health, Infection & Immunity, Smits, Bas, Goldacker, Sigune, Seneviratne, Suranjith, Malphettes, Marion, Longhurst, Hilary, Mohamed, Omar E., Witt-Rautenberg, Carla, Leeman, Lucy, Schwaneck, Eva, Raymond, Isabelle, Meghit, Kilifa, Uhlmann, Annette, Winterhalter, Christine, van Montfrans, Joris, Klima, Marion, Workman, Sarita, Fieschi, Claire, Lorenzo, Lorena, Boyle, Sonja, Onyango-Odera, Shamin, Price, Suzanne, Schmalzing, Marc, Aurillac, Valerie, Prasse, Antje, Hartmann, Ieneke, Meerburg, Jennifer J., Kemner-van de Corput, Mariette, Tiddens, Harm, Grimbacher, Bodo, Kelleher, Peter, Patel, Smita Y., Korganow, Anne Sophie, Viallard, Jean Francois, Tony, Hans Peter, Bethune, Claire, Schulze-Koops, Hendrik, Witte, Torsten, Huissoon, Aarnoud, Baxendale, Helen, Grigoriadou, Sofia, Oksenhendler, Eric, Burns, Siobhan O., and Warnatz, Klaus

Published
2023

26. Effectiveness of Different Rituximab Doses Combined with Leflunomide in the Treatment or Retreatment of Rheumatoid Arthritis: Part 2 of a Randomized, Placebo-Controlled, Investigator-Initiated Clinical Trial (AMARA)

Author

Koehm, Michaela, primary, Foldenauer, Ann C., additional, Rossmanith, Tanja, additional, Alten, Rieke, additional, Aringer, Martin, additional, Backhaus, Marina, additional, Burmester, Gerd R., additional, Feist, Eugen, additional, Kellner, Herbert, additional, Krueger, Klaus, additional, Müller-Ladner, Ulf, additional, Rubbert-Roth, Andrea, additional, Tony, Hans-Peter, additional, Wassenberg, Siegfried, additional, Burkhardt, Harald, additional, and Behrens, Frank, additional

Published
2022
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30. Risiko für kardiovaskuläre Ereignisse unter Januskinase-Inhibitoren bei Patienten mit rheumatoider Arthritis in der Routineversorgung: Beobachtungsdaten aus dem deutschen RABBIT-Register

Author

Meissner, Yvette, Albrecht, Katinka, Kekow, Jörn, Zinke, Silke, Tony, Hans-Peter, Schäfer, Martin, and Strangfeld, Anja

Subjects
Medicine and health
Abstract

Einleitung: Im Jahr 2021 gaben sowohl die europäische als auch die US-amerikanische Zulassungsbehörde aufgrund von Zwischenergebnissen der Oral-Surveillance-Studie [ref:1] Warnungen zur kardiovaskulären (CV) Sicherheit des Januskinase-Inhibitors (JAKi) Tofacitinib heraus und [zum vollständigen Text gelangen Sie über die oben angegebene URL]

Published
2022
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31. Rheumatoide Arthritis

Author

Kneitz, Christian, Tony, Hans-Peter, Schölmerich, Jürgen, editor, Burdach, S., editor, Drexler, H., editor, Hallek, M., editor, Hiddemann, W., editor, Hörl, W.H., editor, Klein, H., editor, Landthaler, M., editor, Lenz, K., editor, Mann, K., editor, Mössner, J., editor, Müller-Ladner, U., editor, Reichen, J., editor, Schmiegel, W., editor, Schröder, J.O., editor, Seeger, W., editor, Stremmel, W., editor, Suttorp, N., editor, Weilemann, L.S., editor, and Wöhrle, J.C., editor

Published
2005
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32. Clinical Utility of C-Reactive Protein and White Blood Cell Count for Scheduling an [18F]FDG PET/CT in Patients with Giant Cell Arteritis

Author

Fröhlich, Matthias, primary, Werner, Rudolf A., primary, Guggenberger, Konstanze V., additional, Vogt, Marius L., additional, Rowe, Steven P., additional, Higuchi, Takahiro, additional, Schmalzing, Marc, additional, Tony, Hans-Peter, additional, Buck, Andreas K., additional, and Bley, Thorsten A., additional

Published
2022
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33. Erkrankungen von Knochen, Muskeln und Gelenken

Author

Schröder, Johann O., Müller-Ladner, Ulf, Jens, Schaumburger, Joachim, Grifka, Ulrike, Woenckhaus, Martin, Fleck, Ulrich, Hans-Wolfram, Gödde, Andrea, Lamprecht, Peter, Kneitz, Christian, Tony, Hans-Peter, Glück, Thomas, Wollenhaupt, Jürgen, Harten, Pontus, Von Kempis, Johannes, Schölmerich, Jürgen, editor, Burdach, Stefan, editor, Diehl, Volker, editor, Drexler, Helmut, editor, Hiddemann, Wolfgang, editor, Hörl, Walter H., editor, Klein, Helmfried, editor, Landthaler, Michael, editor, Lenz, Kurt, editor, Mann, Klaus, editor, Mössner, Joachim, editor, Müller-Ladner, Ulf, editor, Reichen, Jürg, editor, Schmiegel, Wolff, editor, Schröder, Johann Oltmann, editor, Seeger, Werner, editor, Stremmel, Wolfgang, editor, Suttorp, Norbert, editor, and Weilemann, L. Sacha, editor

Published
2003
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35. Antimodified protein antibody response pattern influences the risk for disease relapse in patients with rheumatoid arthritis tapering disease modifying antirheumatic drugs

Author

Figueiredo, Camille P, Bang, Holger, Cobra, Jayme Fogagnolo, Englbrecht, Matthias, Hueber, Axel J, Haschka, Judith, Manger, Bernhard, Kleyer, Arnd, Reiser, Michaela, Finzel, Stephanie, Tony, Hans-Peter, Kleinert, Stefan, Wendler, Joerg, Schuch, Florian, Ronneberger, Monika, Feuchtenberger, Martin, Fleck, Martin, Manger, Karin, Ochs, Wolfgang, Schmitt-Haendle, Matthias, Lorenz, Hanns-Martin, Nuesslein, Hubert, Alten, Rieke, Henes, Joerg, Krueger, Klaus, Rech, Jürgen, and Schett, Georg

Published
2017
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37. Sarilumab reduces disease activity in rheumatoid arthritis patients with inadequate response to janus kinase inhibitors or tocilizumab in regular care in Germany

Author

Tony, Hans-Peter, primary, Feist, Eugen, additional, Aries, Peer Malte, additional, Zinke, Silke, additional, Krüger, Klaus, additional, Ahlers, Jonas, additional, Albrecht, Inka, additional, Barrionuevo, Christian, additional, Kalus, Stefanie, additional, and Burkhardt, Harald, additional

Published
2022
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38. Whole-Body [18F]FDG PET/CT Can Alter Diagnosis in Patients with Suspected Rheumatic Disease

Author

Fröhlich, Matthias, Serfling, Sebastian, Higuchi, Takahiro, Pomper, Martin G., Rowe, Steven P., Schmalzing, Marc, Tony, Hans-Peter, Gernert, Michael, Strunz, Patrick-Pascal, Portegys, Jan, Schwaneck, Eva-Christina, Gadeholt, Ottar, Weich, Alexander, Buck, Andreas K., Bley, Thorsten A., Guggenberger, Konstanze V., and Werner, Rudolf A.

Subjects
musculoskeletal diseases, Medicine (General), vasculature, R5-920, giant cell arteritis, inflammation, GCA, ddc:610, [18F]FDG PET/CT, polymyalgia rheumatica
Abstract

The 2-deoxy-d-[18F]fluoro-D-glucose (FDG) positron emission tomography/computed tomography (PET/CT) is widely utilized to assess the vascular and articular inflammatory burden of patients with a suspected diagnosis of rheumatic disease. We aimed to elucidate the impact of [18F]FDG PET/CT on change in initially suspected diagnosis in patients at the time of the scan. Thirty-four patients, who had undergone [18F]FDG PET/CT, were enrolled and the initially suspected diagnosis prior to [18F]FDG PET/CT was compared to the final diagnosis. In addition, a semi-quantitative analysis including vessel wall-to-liver (VLR) and joint-to-liver (JLR) ratios was also conducted. Prior to [18F]FDG PET/CT, 22/34 (64.7%) of patients did not have an established diagnosis, whereas in 7/34 (20.6%), polymyalgia rheumatica (PMR) was suspected, and in 5/34 (14.7%), giant cell arteritis (GCA) was suspected by the referring rheumatologists. After [18F]FDG PET/CT, the diagnosis was GCA in 19/34 (55.9%), combined GCA and PMR (GCA + PMR) in 9/34 (26.5%) and PMR in the remaining 6/34 (17.6%). As such, [18F]FDG PET/CT altered suspected diagnosis in 28/34 (82.4%), including in all unclear cases. VLR of patients whose final diagnosis was GCA tended to be significantly higher when compared to VLR in PMR (GCA, 1.01 ± 0.08 (95%CI, 0.95–1.1) vs. PMR, 0.92 ± 0.1 (95%CI, 0.85–0.99), p = 0.07), but not when compared to PMR + GCA (1.04 ± 0.14 (95%CI, 0.95–1.13), p = 1). JLR of individuals finally diagnosed with PMR (0.94 ± 0.16, (95%CI, 0.83–1.06)), however, was significantly increased relative to JLR in GCA (0.58 ± 0.04 (95%CI, 0.55–0.61)) and GCA + PMR (0.64 ± 0.09 (95%CI, 0.57–0.71); p < 0.0001, respectively). In individuals with a suspected diagnosis of rheumatic disease, an inflammatory-directed [18F]FDG PET/CT can alter diagnosis in the majority of the cases, particularly in subjects who were referred because of diagnostic uncertainty. Semi-quantitative assessment may be helpful in establishing a final diagnosis of PMR, supporting the notion that a quantitative whole-body read-out may be useful in unclear cases.

Published
2021

39. Immunological Adverse Events After Autologous Hematopoietic Stem Cell Transplantation in Systemic Sclerosis Patients

Author

Strunz, Patrick-Pascal, Froehlich, Matthias, Gernert, Michael, Schwaneck, Eva Christina, Fleischer, Anna, Pecher, Ann-Christin, Tony, Hans-Peter, Henes, Joerg Christoph, and Schmalzing, Marc

Subjects
Adult, Male, Immunology, Graft vs Host Disease, autoimmune disease, Transplantation, Autologous, Autoimmune Diseases, Young Adult, engraftment syndrome, Risk Factors, Humans, scleroderma, ddc:610, Original Research, Retrospective Studies, fever, Scleroderma, Systemic, Hematopoietic Stem Cell Transplantation, Syndrome, RC581-607, Middle Aged, Treatment Outcome, Sjögren’s syndrome, Grave’s disease, Female, Immunologic diseases. Allergy, risk factor analysis, modified Rodnan skin score (mRSS)
Abstract

Autologous hematopoietic stem cell transplantation (aHSCT) represents an effective treatment for systemic sclerosis (SSc), but it also can cause immunological adverse events (iAEs). Therefore, we aimed to determine the frequency of iAEs [engraftment syndrome (ES) and secondary autoimmune disorder (sAD)] and to identify potential risk factors for their development in a retrospective analysis on 22 patients similarly transplanted due to SSc. While nine patients (41%) suffered from ESs, seven sADs occurred in six patients (27%). Patients who developed ES were older in our cohort (52.45 vs. 42.58 years, p = .0433, Cohen’s d = 0.86), and cardiac involvement by SSc was associated with development of ES (OR = 40.11, p = .0017). Patients with manifestation of sAD had a higher modified Rodnan skin score (mRSS) reduction after aHSCT (90.50% vs. 60.00%, p = .0064, r = .65). Thus, IAEs are common after aHSCT for SSc and can occur in different stages during and after aHSCT with characteristic clinical manifestations. Good cutaneous response after aHSCT might be considered as a risk factor for sAD, and higher age at aHSCT and cardiac involvement might be considered as risk factors for the development of ES.

Published
2021

40. German guidelines for the sequential medical treatment of rheumatoid arthritis with traditional and biologic disease-modifying antirheumatic drugs

Author

Albrecht, Katinka, Krüger, Klaus, Wollenhaupt, Jürgen, Alten, Rieke, Backhaus, Marina, Baerwald, Christoph, Bolten, Wolfgang, Braun, Jürgen, Burkhardt, Harald, Burmester, Gerd R., Gaubitz, Markus, Gause, Angela, Gromnica-Ihle, Erika, Kellner, Herbert, Kuipers, Jens, Krause, Andreas, Lorenz, Hans-Martin, Manger, Bernhard, Nüßlein, Hubert, Pott, Hans-Georg, Rubbert-Roth, Andrea, Schneider, Matthias, Specker, Christof, Schulze-Koops, Hendrik, Tony, Hans-Peter, Wassenberg, Siegfried, and Müller-Ladner, Ulf

Published
2014
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41. Relapse rates in patients with rheumatoid arthritis in stable remission tapering or stopping antirheumatic therapy: interim results from the prospective randomised controlled RETRO study

Author

Haschka, Judith, Englbrecht, Matthias, Hueber, Axel J, Manger, Bernhard, Kleyer, Arnd, Reiser, Michaela, Finzel, Stephanie, Tony, Hans-Peter, Kleinert, Stefan, Feuchtenberger, Martin, Fleck, Martin, Manger, Karin, Ochs, Wolfgang, Schmitt-Haendle, Matthias, Wendler, Joerg, Schuch, Florian, Ronneberger, Monika, Lorenz, Hanns-Martin, Nuesslein, Hubert, Alten, Rieke, Demary, Winfried, Henes, Joerg, Schett, Georg, and Rech, Juergen

Published
2016
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47. Apps in rheumatology

Author

Strunz, Patrick-Pascal, primary, Maire, Maxime Le, additional, Heusinger, Tobias, additional, Hammel, Ludwig, additional, Gernert, Michael, additional, Schwaneck, Eva C., additional, Callhoff, Johanna, additional, Portegys, Jan, additional, Schmalzing, Marc, additional, Tony, Hans-Peter, additional, and Froehlich, Matthias, additional

Published
2021
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48. Induction of IL-9 in Peripheral Lymphocytes of Rheumatoid Arthritis Patients and Healthy Donors by Th17-Inducing Cytokine Conditions

Author

Heim, Jana, Almanzar, Giovanni, Schmalzing, Marc, Gernert, Michael, Tony, Hans-Peter, and Prelog, Martina

Subjects
rheumatoid arthritis, Adult, Male, Immunology, Autoimmunity, Lymphocyte Activation, Immunophenotyping, Arthritis, Rheumatoid, Th9, Humans, ddc:610, Cells, Cultured, Original Research, Cell Proliferation, PU.1, Interleukin-9, Cell Differentiation, T-Lymphocytes, Helper-Inducer, RC581-607, Middle Aged, Flow Cytometry, Phenotype, Case-Control Studies, Th17 Cells, Female, Th17, Immunologic diseases. Allergy, Signal Transduction
Abstract

IL-9-producing Th9 cells display a group of helper T cells with similarities to Th17 and Th2 T cells and have been shown to be involved in synovial inflammation in rheumatoid arthritis (RA) patients. So far, it is unclear which parameters drive Th9 differentiation in lymphocytes derived from RA patients compared to immunologically healthy individuals and whether autocrine mechanisms are able to enhance Th9 polarization. Further, parallel pathways of induction of IL-17-producing cells with Th9 phenotype have to be distinguished from exclusively Th9-inductive mechanisms. Thus, the present study aimed to determine the parameters of Th9 induction by simulation in a standardized inflammatory cytokine milieu.Peripheral naive and non-naive T cells of RA patients and healthy donors (HD) were cultured under Th9 and Th17-driving conditions and phenotypically analyzed by flow cytometry and molecular analysis.Our findings indicate a similar differentiation pathway of Th9 and Th17 cells and similar distributions of IL-9+ T cells in RA and HD regardless of Th9- or Th17-promoting cytokine milieus. Whereas the magnitude and direction of Th9- or Th17-polarization was about the same in RA and HD, IL-17+ CD4+ T cells were significantly stimulated by Th17-inducing conditions in HD. In conclusion, the results indicate that Th9- and Th17-inducing cytokine conditions mimicking autoimmune inflammation in RA may have similar stimulatory effects regarding polarization of peripheral naive and non-naive T cells into Th9 or Th17 cells. The results suggest that the differentiation of Th9 cells may be also induced by Th17-driving conditions.

Published
2021

49. High Prevalence of Genital Human Papillomavirus Infection in Patients With Primary Immunodeficiencies

Author

Gernert, Michael, Kiesel, Matthias, Fröhlich, Matthias, Renner, Regina, Strunz, Patrick-Pascal, Portegys, Jan, Tony, Hans-Peter, Schmalzing, Marc, and Schwaneck, Eva Christina

Subjects
Adult, Male, Primary Immunodeficiency Diseases, Immunology, primary immunodeficiency, Risk Assessment, Human Papillomavirus DNA Tests, Immunocompromised Host, Young Adult, Risk Factors, Germany, Prevalence, Humans, ddc:610, human papillomavirus, Original Research, Aged, Papillomavirus Infections, virus diseases, Middle Aged, RC581-607, female genital diseases and pregnancy complications, inborn errors of immunity (IEIs), Cross-Sectional Studies, Condylomata Acuminata, Female, common variable immunodeficiency (CVID), ddc:301, Immunologic diseases. Allergy, genital warts
Abstract

Background Genital human papillomavirus (HPV)-infections are common in the general population and are responsible for relevant numbers of epithelial malignancies. Much data on the HPV-prevalence is available for secondary immunodeficiencies, especially for patients with human immunodeficiency virus (HIV)-infection. Little is known about the genital HPV-prevalence in patients with primary immunodeficiencies (PIDs). Methods We performed a cross-sectional study of patients with PIDs and took genital swabs from male and female patients, which were analyzed with polymerase chain reaction for the presence of HPV-DNA. Clinical and laboratory data was collected to identify risk factors. Results 28 PID patients were included in this study. 10 of 28 (35.7%) had HPV-DNA in their genital swabs. 6 patients had high-risk HPV-types (21.4%). Most patients had asymptomatic HPV-infections, as genital warts were rare (2 of 28 patients) and HPV-associated malignancy was absent. Differences in the HPV-positivity regarding clinical PID-diagnosis, duration of PID, age, sex, immunosuppression, immunoglobulin replacement, or circumcision in males were not present. HPV-positive PID patients had higher numbers of T cells (CD3\(^+\)), of cytotoxic T cells (CD3\(^+\)/CD8\(^+\)), of transitional B cells (CD19\(^+\)/CD38\(^{++}\)/CD10\(^+\)/IgD\(^+\)), and of plasmablasts (CD19\(^+\)/CD38\(^+\)/CD27\(^{++}\)/IgD\(^-\)) compared to HPV-negative. Conclusion PID patients exhibit a high rate of genital HPV-infections with a high rate of high-risk HPV-types. Regular screening for symptomatic genital HPV-infection and HPV-associated malignancy in PID patients seems recommendable.

Published
2021

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