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Abstract Aims The endoscopic treatment of esophagogastric varices is challenging, and the nationwide application of endoscopic therapies for various types of esophagogastric varices and different clinical scenarios remains unclear. This study investigated the use of endoscopic therapy for portal hypertension in China. Methods This study used a questionnaire survey initiated by the Liver Health Consortium in China to investigate the use of endoscopic therapies for portal hypertension. Questionnaires were released online from January 30, 2023 to February 28, 2023 and filled out by chief physicians or senior instructors responsible for endoscopic therapies in participating hospitals across 31 provinces (autonomous regions and municipalities) in China. Comparisons of guideline adherence between primary and referral medical centers were performed using the chi‐square test or Fisher's exact test. Results In total, 836 hospitals participated in the survey. For primary and secondary prophylaxis of esophagogastric variceal bleeding (EGVB), adherence to the national guidelines was 72.5% (606/836) and 39.2% (328/836), respectively. Significant differences were observed in the rate of adherence between the primary and referral centers for primary (79.9% [111/139] vs. 71.0% [495/697], p = 0.033) and secondary prophylaxis (27.3% [38/139] vs. 41.6% [290/697], p = 0.002). Of the hospitals, 78.2% (654/836) preferred endoscopic therapies for acute EGVB, and the timing of endoscopy was usually within 12 h (48.5%, 317/654) and 12–24 h (36.9%, 241/654) after bleeding. Endoscopic therapy was more likely to be the first choice of treatment for acute EGVB in referral centers than in primary centers (82.6% [576/697] vs. 56.1% [78/139], p

[Introduction] Aiming at the characteristics of offshore converter stations, the design scheme for wireless communication system of offshore converter station is proposed. [Method] By analyzing the characteristics and current application of offshore wireless communication technology and considering the requirements of equipment operation, station warning and personnel activities of offshore converter stations, the configuration scheme for the wireless communication system of offshore converter stations was proposed. [Result] Through the NAVTEX system, the requirement to receive weather and safety information is realized. Through the radar optoelectronic system and VHF ship to ship communication system, the requirement for vessel caution and expulsion is realized. Through UHF cluster intercom system, WiFi and mobile communication system, the daily communication requirement of personnel is realized. Through the lifeboat emergency communication system, microwave transmission system and satellite communication system, the requirement of personnel emergency avoidance is realized. [Conclusion] Therefore, the system can realize the basic communication requirements during the daily operation and maintenance of offshore converter stations, ensure the safety of equipment and personnel, and provide guidance for the design of wireless communication systems for offshore converter stations.

Abstract Alfvén waves are important carriers of solar wind energy into the Earth's magnetosphere and upper atmosphere. The observed distribution of Alfvénic power at low altitude exhibits significant dawn‐dusk asymmetry with different causes and impacts on the dayside and nighside. The nightside asymmetry has been shown to be controlled by the meridional gradient in the ionospheric Hall conductance. It is not clear what controls the dayside asymmetry. Both the ionospheric conductance gradient and orientation of the y‐component of the interplanetary magnetic field (IMF) are possible factors. We examined both possibilities using global magnetohydrodynamic (MHD) simulations. Our results show: (a) The dayside distribution of Alfvénic power is very sensitive to the orientation of IMF By, with enhanced power in the dawn (dusk) sector of the northern hemisphere for positive (negative) By (and opposite in the southern hemisphere); and (b) gradients in ionospheric conductance exert a weaker influence on the dayside asymmetry.

Abstract Mouse auditory cortex is composed of six sub-fields: primary auditory field (AI), secondary auditory field (AII), anterior auditory field (AAF), insular auditory field (IAF), ultrasonic field (UF) and dorsoposterior field (DP). Previous studies have examined thalamo-cortical connections in the mice auditory system and learned that AI, AAF, and IAF receive inputs from the ventral division of the medial geniculate body (MGB). However, the functional and thalamo-cortical connections between nonprimary auditory cortex (AII, UF, and DP) is unclear. In this study, we examined the locations of neurons projecting to these three cortical sub-fields in the MGB, and addressed the question whether these cortical sub-fields receive inputs from different subsets of MGB neurons or common. To examine the distributions of projecting neurons in the MGB, retrograde tracers were injected into the AII, UF, DP, after identifying these areas by the method of Optical Imaging. Our results indicated that neuron cells which in ventral part of dorsal MGB (MGd) and that of ventral MGB (MGv) projecting to UF and AII with less overlap. And DP only received neuron projecting from MGd. Interestingly, these three cortical areas received input from distinct part of MGd and MGv in an independent manner. Based on our foundings these three auditory cortical sub-fields in mice may independently process auditory information.

BackgroundIt is unclear whether patients with metabolic dysfunction-associated steatotic liver disease (MASLD) are allowed variable low levels of alcohol. This study aimed to evaluate the effect of mild-moderate alcohol consumption on the biochemical and histological characteristics of patients with MASLD.MethodsAlcohol consumption was assessed in 713 patients with steatotic liver disease (SLD) who underwent liver biopsy. Non-drinking, mild-moderate drinking, and excessive drinking were defined as 0 g/day, 1-20 g/day for women and 0 g/day, 1-30 g/day for men, respectively. Liver biopsies were scored according to the NASH CRN system.ResultsA total of 713 participants (median age 39.0 years and 77.1% male) with biopsy-proven SLD were enrolled, including 239 nondrinkers, 269 mild-moderate drinkers and 205 excessive drinkers. Excessive drinking was associated with increased risks for lobular inflammation and liver fibrosis compared to nondrinkers and mild-moderate drinkers. Compared with non-drinkers, mild-moderate drinkers had significantly lower odds for steatosis (OR = 0.60, 95% CI = 0.38–0.93, p = 0.025), hepatocellular ballooning (OR = 0.52, 95% CI = 0.29–0.91, p = 0.020) and fibrosis (OR = 0.50, 95% CI = 0.31–0.81, p = 0.005). However, in non-excessive drinkers with type 2 diabetes mellitus (T2DM), there was no association between mild-moderate alcohol consumption and liver fibrosis (OR = 0.562, 95% CI = 0.207–1.530, p = 0.257).ConclusionsMild-moderate alcohol consumption might be protective against liver fibrosis in MASLD patients, which is modified by the presence of T2DM. However, further longitudinal studies are needed to determine the effect of ongoing alcohol consumption on disease severity.

In this study, we investigate the solar cycle dependence of the sunrise ionospheric zonal electric fields at the equator under geomagnetically quiet conditions. Simulations using the Thermosphere–Ionosphere–Electrodynamics General Circulation Model (TIEGCM) reveal that the equatorial eastward electric field at sunrise decreases with the increase in solar activity, independent of longitude, season, and lower atmospheric tides. The solar cycle dependence of the sunrise zonal electric field is mainly related to the zonal wind dynamo. Moreover, this solar cycle dependence of sunrise electric fields at the equator is dominated by the corresponding variation in the F-region dynamo because the response of conductivity and neutral winds near sunrise to increasing solar flux is stronger in the F-region than in the E-region, although the sunrise eastward enhancement of electric fields is mainly driven by the E-region zonal wind dynamo. Specifically, the westward gradient of low-latitude F-region neutral winds near the dawn terminator tends to produce westward electric fields in the equatorial region that are more pronounced at solar maximum, whereas the midlatitude E-region dynamo induces an eastward enhancement of sunrise electric fields at the equator that decreases slightly with increasing solar activity. This study also reveals that the reason the eastward enhancement of equatorial zonal electric fields near dawn and dusk terminators show opposite solar cycle dependence is because of their different generation mechanisms.

Abstract Aim The transjugular intrahepatic portosystemic shunt (TIPS) procedure has been performed in China for 30 years, but our understanding of the status and difficulties associated with the use of TIPS for portal hypertension is incomplete. This study aims to investigate the current situation of the use of TIPS for portal hypertension, which should aid the development of TIPS in China. Methods This study involved a questionnaire survey, initiated by the China Portal Hypertension Alliance (CHESS) to investigate the use of TIPS for portal hypertension in China. Questionnaires were released on the Internet between August 16, 2022 and September 16, 2022. Detailed information was collected from 545 hospitals contracted by the CHESS in China, which performed TIPS surgery in 2021. Results The 545 hospitals covers the majority of hospitals in China that conduct TIPS intervention. In the survey, a total of 13,527 TIPS interventions were carried out with 94.1% (498/545) of them had a system of routine follow‐up after TIPS. The majority (42.6% [232/545]) believed that the main indication of TIPS was the control of acute bleeding. Overall, 48.1% (262/545) carried out early or pre‐emptive TIPS, 53.0% (289/545) carried out TIPS for cavernous transformation of the portal vein, and 81.0% (441/545) chose routine embolization of collateral circulation during operation. Most used coils (97.0% [475/490]) and biological glue (72.0% [353/490]) as embolic materials, and 78.5% (428/545) routinely performed intraoperative portal pressure gradient measurements. When selecting TIPS stents, 57.1% (311/545) chose viator‐specific stents, and 57.2% (312/545) chose conventional anticoagulation after TIPS. Conventional anticoagulation after TIPS is over a time interval of 3–6 months (55.4% [173/312]). The limitation of TIPS surgery is mainly its cost (72.3% [394/545]) and insufficient understanding of the procedure by doctors in other related departments (77.4% [422/545]). Most of the hospital teams accept the use of domestic instruments in TIPS surgery (92.7% [505/545]). Conclusions This survey shows that TIPS is an essential part of the treatment of portal hypertension in China. TIPS is widely used in Chinese patients with portal hypertension, and this survey presents a more comprehensive picture of the options and difficulties encountered in the implementation of TIPS. In the future, it is necessary to promote TIPS technology and further standardize surgical indications, routine operations, and instrument application.

Abstract No fully validated risk-stratification strategies have been established in China where colonoscopies resources are limited. We aimed to develop and validate a fecal immunochemical test (FIT)-based risk-stratification model for colorectal neoplasia (CN); 10,164 individuals were recruited from 175 centers nationwide and were randomly allocated to the derivation (n = 6776) or validation cohort (n = 3388). Multivariate logistic analyses were performed to develop the National Colorectal Polyp Care (NCPC) score, which formed the risk-stratification model along with FIT. The NCPC score was developed from eight independent predicting factors and divided into three levels: low risk (LR 0–14), intermediate risk (IR 15–17), and high risk (HR 18–28). Individuals with IR or HR of NCPC score or FIT+ were classified as increased-risk individuals in the risk-stratification model and were recommended for colonoscopy. The IR/HR of NCPC score showed a higher prevalence of CNs (21.8%/32.8% vs. 11.0%, P

The development of fractures in loess slopes often has a great influence on the stability of slopes. In this paper, taking the homogeneous slope model as an example, fractures with different distances and depths from the slope top angle are provided at the top of the slope. Firstly, the influence of single fracture location and depth on slope stability is analyzed, and after the most unfavorable location and depth of the fractures are determined, the influence of the slope top fractures on the slope seepage field and slope stability under the conditions with and without rainfall is studied secondly. The results show that with the increase of the distance from the fracture to the top angle of the slope, the safety coefficient of the slope shows the change law of decreasing first and then increasing. The critical fracture depth corresponding to the fractures at different locations is different, and when the critical fracture depth is exceeded, the slope safety factor tends to be stable. At the end of the rainfall moment through 1-1 section to analyze, it is found that at this time the pore water pressure and volume water content of the soil at the bottom of the fracture at different depths are greater than those of the upper soil, and the shallow fracture has less influence on the seepage field of the slope, and through 2-2 section it is found that the pore water pressure and volume water content in the soil far from the fracture are greater than those of the soil near the location of the fracture. When 288 h after the end of rainfall, the pore water pressure and volumetric water content of the soil around the fracture in section 2-2 were greater than those far from the fracture location. With the passage of time, the pore water pressure at the location of the fracture gradually dissipated and the corresponding volumetric water content gradually decreased, indicating that the fracture had an obvious influence on the characteristics of the seepage field in the soil at different times of rainfall. Under the condition of no rainfall, there exists a critical depth of fractures affecting slope safety stability, while under the condition of rainfall, the slope safety coefficient continuously decreases with the increase of fracture depth, and there is no critical fracture depth. The research results promote the understanding of the safety and stability of loess fracture slopes and provide a reference for slope management.

Abstract The effects of volcanic eruptions on the ionosphere have been well studied, however, evidence for the anticipated upper atmospheric neutral variations and their exact extents of change are rarely available. Here, we report dramatic thermospheric disturbances following the 15 January 2022 Tonga eruption. The GRACE‐FO and Swarm‐C observations from the accelerometers exhibited three successive thermospheric density waves at ∼500 km altitudes propagating concentrically across the globe at 200–450 m/s phase speed and two of the three waves converged at the antipode of the epicenter. A large‐scale and long‐lasting neutral density depletion within a radius of approximately 10,000 km around the epicenter occurred, along with the density enhancement around the antipode of the epicenter. Such an enhancement is comparable in the relative intensity with respect to the no‐eruption condition, to the effect of a moderate geomagnetic storm. This study offers observational evidence of substantial global upper thermospheric perturbations well above their origin near the Earth's surface due to a volcanic eruption.

Layers with low permeability are an important factor affecting the stability of tailings dams. In order to analyze the influence of the weak permeability interlayer on the seepage stability of the dam, this paper establishes a numerical analysis model of the tailings dam with the weak permeability interlayer. The seepage stability of the dam slope is calculated and analyzed for the location, thickness, number, and intervals of mud intercalation on the seepage stability of the dam slope. The weakly permeable interlayers at different locations form different saturation lines in the dam. When the weak permeability interlayer is located in the middle of the dam, the height of the saturation line is the highest, and the corresponding stability safety factor is the smallest. When the weak permeability interlayer moves up or down, the buried depth of the saturation line increases, and the safety factor increases. However, when the weak permeability interlayer is located above the drainage prism, the overall slip along the weak permeability interlayer is incidental to the increase in dam height. When the thickness of the weak permeability interlayer changes, the safety factor of the dam has a positively high significance related to the leakage. When the location of the weak permeability interlayer changes, the safety factor of the dam has no obvious correlation with the leakage. With the increase of the thickness and number of weak pemeability interlayer and the decrease of the intervals of mud intercalation, the height of the saturation line gradually increases, and the safety factor of the dam gradually decreases. Through the location of the sliding surface, it is found that the sliding surface eventually destabilizes through the lowest low-permeability interlayer.

Excessive cholesterol in the liver is harmful for our health and may cause many diseases, such as fatty liver disease. Many studies in human and animal models have reported that royal jelly (RJ) can be used to treat atherosclerosis. However, the real mechanisms behind this action is unclear. In this study, we investigated the efficacy of RJ on gene expression of squalene epoxidase (SE) a major enzyme involved in cholesterol biosynthesis in HepG2 cells. We found that the expression of SE was decreased in response to RJ treatment. We also found that the origin of the RJ affected its strength. To find out the active fraction of RJ in cholesterol suppression, we separated RJ into two parts based on the molecular weights using ultrafiltration membrane. We found that the fraction

Background: Only a small proportion of patients with compensated advanced chronic liver disease (cACLD) had varices needing treatment (VNT) after recommended esophagogastroduodenoscopy (EGD) screening. We aimed to create a non-invasive nomogram based on routine tests to detect VNT in cACLD patients. Methods: The training cohort included 162 cACLD patients undergoing EGD in a university hospital, between January 2014 and September 2019. A nomogram was developed based on the independent predictors of VNT, selected using a multivariate logistic regression analysis. Thirty-three patients from eight university hospitals were prospectively enrolled as validation cohort between December 2018 and December 2019. Results: The prevalence of VNT was 32.7% (53/162) and 39.4% (13/33) in training and validation cohorts, respectively. The univariate analysis identified six risk factors for VNT. On the multivariate analysis, four of them, i.e., gallbladder wall thickness (odds ratio [OR]: 1.23; 95% confidence interval [CI]: 0.98-1.56), spleen diameter (OR: 1.02; 95% CI: 1.00-1.04), platelet count (OR: 0.98; 95% CI: 0.97-0.99), and international normalized ratio (OR: 0.58; 95% CI: 0.06-5.84) were independently associated with VNT. Thus, a nomogram based on the four above - mentioned variables was developed, and showed a favorable performance for detecting VNT, with an area under receiver operating characteristic curve of 0.848 (95% CI: 0.769-0.927) in training cohort. By applying a cut-off value of 105 in validation cohort, 31.0% of EGD were safely spared with 3.4% of missed VNT. Conclusion: A nomogram based on routine clinical parameters was developed for detecting VNT and avoiding unnecessary EGD in cACLD patients.

Background and AimsEmergency endoscopy is recommended for patients with acute esophageal variceal bleeding (EVB) and their prognosis has improved markedly over past decades due to the increased specialization of endoscopic practice. The study aimed to compare outcomes following emergency endoscopic injection sclerotherapy (EIS) and endoscopic variceal ligation (EVL) in cirrhotic patients with acute EVB.MethodsCirrhotic patients with acute EVB who underwent emergency endoscopy were retrospectively enrolled from 2013 to 2020 across 34 university hospitals from 30 cities. The primary outcome was the incidence of 5-day rebleeding after emergency endoscopy. Subgroup analysis was stratified by Child-Pugh class and bleeding history. A 1:1 propensity score matching (PSM) analysis was performed.ResultsA total of 1,017 and 382 patients were included in EIS group and EVL group, respectively. The 5-day rebleeding incidence was similar between EIS group and EVL group (4% vs. 5%, P = 0.45). The result remained the same after PSM (P = 1.00). Among Child-Pugh class A, B and C patients, there were no differences in the 5-day rebleeding incidence between the two groups after PSM (P = 0.25, 0.82, and 0.21, respectively). As for the patients with or without bleeding history, the differences between EIS group and EVL group were not significant after PSM (P = 1.00 and 0.26, respectively).ConclusionThe nationwide cohort study indicates that EIS and EVL are both efficient emergency endoscopic treatment strategies for acute EVB. EIS should not be dismissed as an economical and effective emergency endoscopic treatment strategy of acute EVB. ClincialTrials.gov number NCT04307264.

Ultrasoft magnetorheological elastomers (MREs) offer convenient real-time magnetic field control of mechanical properties that provides a means to mimic mechanical cues and regulators of cells in vitro. Here, we systematically investigate the effect of polymer stiffness on magnetization reversal of MREs using a combination of magnetometry measurements and computational modeling. Poly-dimethylsiloxane-based MREs with Young’s moduli that range over two orders of magnitude were synthesized using commercial polymers Sylgard™ 527, Sylgard 184, and carbonyl iron powder. The magnetic hysteresis loops of the softer MREs exhibit a characteristic pinched loop shape with almost zero remanence and loop widening at intermediate fields that monotonically decreases with increasing polymer stiffness. A simple two-dipole model that incorporates magneto-mechanical coupling not only confirms that micrometer-scale particle motion along the applied magnetic field direction plays a defining role in the magnetic hysteresis of ultrasoft MREs but also reproduces the observed loop shapes and widening trends for MREs with varying polymer stiffnesses.

Abstract Background Many studies have found that large tumor suppressor kinase 1 (LATS1) and LATS2 play important roles in many diseases, but studies have been rare on the relationship between these genes and non-cardia gastric cancer (GC). We performed a case-control association study to investigate the associations between single nucleotide polymorphisms (SNPs) in LATS1 and LATS2 genes and Helicobacter pylori (H. pylori) infection as well as the risk of non-cardia GC. Methods First, H. pylori infection was determined by the serological test using enzyme-linked immunoassay. Then genotyping of SNPs was performed for 808 samples by the Taqman method. Finally, unconditional logistic regression was used to calculate the odds ratios (ORs) and 95% confidence intervals (CIs), adjusted for age and gender, for the association of each SNP with the infection of H. pylori, the risk of non-cardia gastric cancer, as well as the expression of LATS1 and LATS2 proteins in non-cardia GC tissues, using the codominant, dominant, recessive, overdominant, and log-additive inheritance models, respectively. Results The statistical results showed that LATS2 rs9552315 was associated with H. pylori infection, and the CC + CT genotype could reduce the risk of H. pylori infection (odds ratio [OR]: 0.549, 95% confidence interval [CI]: 0.339–0.881, P

On 21 June 2020, an annular solar eclipse will traverse the low latitudes from Africa to Southeast Asia. The highest latitude of the maximum eclipse obscuration is approximately 30°. This low-latitude solar eclipse provides a unique and unprecedented opportunity to explore the impact of the eclipse on the low-latitude ionosphere–thermosphere (I–T) system, especially in the equatorial ionization anomaly region. In this study, we describe a quantitative prediction of the impact of this upcoming solar eclipse on the I–T system by using Thermosphere–Ionosphere–Electrodynamics General Circulation Model simulations. A prominent total electron content (TEC) enhancement of around 2 TEC units occurs in the equatorial ionization anomaly region even when this region is still in the shadow of the eclipse. This TEC enhancement lasts for nearly 4.5 hours, long after the solar eclipse has ended. Further model control simulations indicate that the TEC increase is mainly caused by the eclipse-induced transequatorial plasma transport associated with northward neutral wind perturbations, which result from eclipse-induced pressure gradient changes. The results illustrate that the effect of the solar eclipse on the I–T system is not transient and linear but should be considered a dynamically and energetically coupled system.

Background : Esophageal cancer is one of the most common and deadliest cancers in the world, particularly esophageal adenocarcinoma. There has never been a special drug to treat it. Purpose : This article summarizes the work that we have done in our laboratory about the role of CCN1 in esophageal cancer and gives a new perspective of CCN1 biology. Research Design : This is a review article. Study Sample : The work was done using validated cell lines and fixed human tissue slides. Data Collection and Analysis : This is a review article, therefore, no data collection or analysis was involved. Results : CCN1 is a matricellular protein supporting adhesion, migration, and survival in normal cells, but in the esophageal cancer cells, it induces TRAIL-mediated apoptosis. CCN1 promotes TRAIL and its death receptor expression but downregulates the decoy receptors and survivin in a p53-dependant manner. It was thought that CCN1 relies on TNF to induce apoptosis, but our study found that these two molecules antagonize each other. CCN1 promotes TNFR1 cleavage and uses the soluble product to block TNF signaling, while TNF upregulates PGLYRP1 to overcome this obstacle because PGLYRP1 is a secreted protein that competes with TNF for TNFR1 binding. As a result, when CCN1 and TNF are present together in the vicinity of esophageal tumors, they cancel each other out. Conclusions : Based on our laboratory study, CCN1 has much potential to be a candidate for the treatment of esophageal cancer.

In this paper, we present a new tool to investigate the interaction of the solar wind with Venus with the approach of a global multifluid magnetohydrodynamics (MHD) model. The continuity, momentum, and energy equations for H ^+ , O ^+ , ${{\rm{O}}}_{2}^{+}$ , and ${\mathrm{CO}}_{2}^{+}$ are solved self-consistently together with Faraday’s law. The photochemistry of ionospheric ions are considered as the source term in the density, momentum, and energy equations for each ion. We found that the simulated ionospheric density, temperature, and the bow shock location are consistent with previous observations and simulations for both the solar maximum and minimum. The simulated magnetic fields also agree well with the Venus Express observations. Meanwhile, the high-resolving power and low numerical diffusion makes the model capable of capturing the fine structures of the Venusian-induced magnetosphere, such as the Kelvin–Helmholtz instability and the nightside wake. The escape rates have also been estimated and the results are similar to previous estimations. The high-resolution model could be an efficient tool for the exploration of the fine structures of the Venusian space environment system, and also for the application to other unmagnetized planets.

DNA mutation is a common event in the human body, but in most situations, it is fixed right away by the DNA damage response program. In case the damage is too severe to repair, the programmed cell death system will be activated to get rid of the cell. However, if the damage affects some critical components of this system, the genetic scars are kept and multiply through mitosis, possibly leading to cancer someday. There are many forms of programmed cell death, but apoptosis and necroptosis represent the default and backup strategy, respectively, in the maintenance of optimal cell population as well as in cancer prevention. For the same reason, the ideal approach for cancer treatment is to induce apoptosis in the cancer cells because it proceeds 20 times faster than tumor cell proliferation and leaves no mess behind. Induction of necroptosis can be the second choice in case apoptosis becomes hard to achieve, however, necroptosis finishes the job at a cost—inflammation.

Background: Gastroesophageal varices is a serious complication of compensated advanced chronic liver disease (cACLD). Primary prophylaxis to reduce the risk of variceal hemorrhage is recommended if high-risk varices (HRV) are detected. We performed this study to compare the accuracy, patients’ satisfaction and safety of detection of HRV by detachable string magnetically controlled capsule endoscopy (DS-MCCE) with esophagogastroduodenoscopy (EGD) as the reference. Methods: We prospectively recruited participants with cACLD from 12 university hospitals (11 in China and one in the United Kingdom) between November 2018 and December 2019 (ClinicalTrials.gov, NCT03749954). All participants underwent DS-MCCE, followed by EGD within a week in a blinded fashion. Following endoscopy, and on the same day, participants were asked to fill in a satisfaction questionnaire regarding their experience. Findings: A total of 105 eligible participants were enrolled. With EGD as the reference standard, the concordance index, sensitivity, specificity, positive predictive value, negative predictive value, positive likelihood ratio, and negative likelihood ratio of DS-MCCE in diagnosis of HRV were 0•90 (95% confidence interval [CI]: 0•83–0•95), 92% (95% CI: 78–98%), 88% (95% CI: 78–95%), 80% (95% CI: 70–92%), 95% (95% CI: 90–100%), 7•91 (95% CI: 4•10–15•30), and 0•09 (95% CI: 0•03–0•30), respectively. The kappa score of 0•78 (95% CI: 0•65–0•90) suggested substantial agreement between DS-MCCE and EGD. Moreover, in participants undergoing EGD without sedation, the satisfaction of DS-MCCE was significantly better than that of EGD (p < 0•0001, d = 1•15 [95%CI: 0•88–1•42]). All participants confirmed the excretion of the capsule, and no adverse events occurred. Interpretation: DS-MCCE is an accurate alternative to EGD for detecting HRV in cACLD, which is safe and associated with better satisfaction. Funding: A full list of funding can be found in the Funding Support section.

Background. It is pretty well known that DNA methyltransferases (DNMTs) are actively involved in abnormal cell growth. The goal of the current study is to explore the correlation between DNMT expression and colorectal adenomatous polyps (CAPs). Method. Twenty pairs of CAP samples with a diameter≥10 mm and corresponding normal colorectal mucosa (NCM) tissues from patients were used in the present study. The expression levels and activity of DNA methyltransferases (DNMTs) were measured in the CAP tissues. The global methylation and the promoter methylation level of 3 kinds of tumour suppressor gene were detected. Results. mRNA and protein levels of DNMT3B were found to be elevated in the CAP tissues compared with the control tissue. Additionally, the methylation of long interspersed nuclear elements-1 (LINE-1/L1) was decreased in the CAP tissue. Furthermore, methylation of the promoter of a tumour suppressor gene Ras association domain family 1A (RASSF1A) was increased in the CAP tissues, while the mRNA levels of RASSF1A were decreased. Conclusions. These results suggest that the overexpression of DNMT3B may contribute to a role in the genesis of CAPs through the hypomethylation of chromosomes in the whole cell and promoter hypermethylation of RASSF1A.

One of the important effects of the ionospheric modification by high-power waves is the airglow enhancement. Both the thermal electrons and the dissociation recombination contribute to generate the airglow emissions during HF heating. However, the relative importance of the airglow emission induced by dissociative recombination and thermal electrons has been rarely investigated. In this study, we carry out a simulation study on the airglow produced by high-power HF heating at nighttime associated with dissociative recombination and thermal electrons. SAMI2 (Sami2 is Another Model of the Ionosphere) is employed to simulate the ionospheric variations during the HF heating. The main conclusions from this study are as follows: (1) For the airglow induced by dissociative recombination, both 630.0 nm and 557.7 nm emissions show a decrease at the heating wave reflection height during the heating period, while when the heating is turned off, an increase is shown at lower altitudes. The reduction of airglow during the heating is caused by the rapid increase of electron temperature and the diffusion of plasmas dominates the after-heating airglow enhancement. (2) 630.0 nm emission due to thermal electrons is greatly enhanced at the wave reflection height, indicating that thermal electrons play a major role in exciting 630.0 nm emission. For the 557.7 nm emission, the excitation threshold (4.17 eV) is too high for thermal electrons. (3) The combined effect of dissociative recombination and thermal electrons could be the possible reason for the observed X-mode (extraordinary mode) suppression of 630.0 nm airglow during O-mode (ordinary mode) enhancement.