Author: "Tong, Z." - Searchworks@Jio Institute Digital Library Search Results

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1. Two-neutrino double electron capture of $^{124}$Xe in the first LUX-ZEPLIN exposure

Author: Aalbers, J., Akerib, D. S., Musalhi, A. K. Al, Alder, F., Amarasinghe, C. S., Ames, A., Anderson, T. J., Angelides, N., Araújo, H. M., Armstrong, J. E., Arthurs, M., Baker, A., Balashov, S., Bang, J., Bargemann, J. W., Barillier, E. E., Beattie, K., Bhatti, A., Biekert, A., Biesiadzinski, T. P., Birch, H. J., Bishop, E., Blockinger, G. M., Boxer, B., Brew, C. A. J., Brás, P., Burdin, S., Buuck, M., Carmona-Benitez, M. C., Carter, M., Chawla, A., Chen, H., Chin, Y. T., Chott, N. I., Converse, M. V., Coronel, R., Cottle, A., Cox, G., Curran, D., Dahl, C. E., David, A., Delgaudio, J., Dey, S., de Viveiros, L., Di Felice, L., Ding, C., Dobson, J. E. Y., Druszkiewicz, E., Dubey, S., Eriksen, S. R., Fan, A., Fearon, N. M., Fieldhouse, N., Fiorucci, S., Flaecher, H., Fraser, E. D., Fruth, T. M. A., Gaitskell, R. J., Geffre, A., Genovesi, J., Ghag, C., Gibbons, R., Gokhale, S., Green, J., van der Grinten, M. G. D., Haiston, J. J., Hall, C. R., Han, S., Hartigan-O'Connor, E., Haselschwardt, S. J., Hernandez, M. A., Hertel, S. A., Heuermann, G., Homenides, G. J., Horn, M., Huang, D. Q., Hunt, D., Jacquet, E., James, R. S., Johnson, J., Kaboth, A. C., Kamaha, A. C., Kannichankandy, M., Khaitan, D., Khazov, A., Khurana, I., Kim, J., Kim, Y. D., Kingston, J., Kirk, R., Kodroff, D., Korley, L., Korolkova, E. V., Kraus, H., Kravitz, S., Kreczko, L., Kudryavtsev, V. A., Leonard, D. S., Lesko, K. T., Levy, C., Lin, J., Lindote, A., Lippincott, W. H., Lopes, M. I., Lorenzon, W., Lu, C., Luitz, S., Majewski, P. A., Manalaysay, A., Mannino, R. L., Maupin, C., McCarthy, M. E., McDowell, G., McKinsey, D. N., McLaughlin, J., McLaughlin, J. B., McMonigle, R., Mizrachi, E., Monte, A., Monzani, M. E., Morrison, E., Mount, B. J., Murdy, M., Murphy, A. St. J., Naylor, A., Nelson, H. N., Neves, F., Nguyen, A., O'Brien, C. L., Olcina, I., Oliver-Mallory, K. C., Orpwood, J., Oyulmaz, K. Y, Palladino, K. J., Palmer, J., Pannifer, N. J., Parveen, N., Patton, S. J., Penning, B., Pereira, G., Perry, E., Pershing, T., Piepke, A., Qie, Y., Reichenbacher, J., Rhyne, C. A., Riffard, Q., Rischbieter, G. R. C., Ritchey, E., Riyat, H. S., Rosero, R., Rushton, T., Rynders, D., Santone, D., Sazzad, A. B. M. R., Schnee, R. W., Sehr, G., Shafer, B., Shaw, S., Shutt, T., Silk, J. J., Silva, C., Sinev, G., Siniscalco, J., Smith, R., Solovov, V. N., Sorensen, P., Soria, J., Stevens, A., Stifter, K., Suerfu, B., Sumner, T. J., Szydagis, M., Tiedt, D. R., Timalsina, M., Tong, Z., Tovey, D. R., Tranter, J., Trask, M., Tripathi, M., Vacheret, A., Vaitkus, A. C., Valentino, O., Velan, V., Wang, A., Wang, J. J., Wang, Y., Watson, J. R., Weeldreyer, L., Whitis, T. J., Wild, K., Williams, M., Wisniewski, W. J., Wolf, L., Wolfs, F. L. H., Woodford, S., Woodward, D., Wright, C. J., Xia, Q., Xu, J., Xu, Y., Yeh, M., Yeum, D., Zha, W., and Zweig, E. A.
Subjects: Nuclear Experiment, Physics - Instrumentation and Detectors
Abstract: The broad physics reach of the LUX-ZEPLIN (LZ) experiment covers rare phenomena beyond the direct detection of dark matter. We report precise measurements of the extremely rare decay of $^{124}$Xe through the process of two-neutrino double electron capture (2$\nu$2EC), utilizing a $1.39\,\mathrm{kg} \times \mathrm{yr}$ isotopic exposure from the first LZ science run. A half-life of $T_{1/2}^{2\nu2\mathrm{EC}} = (1.09 \pm 0.14_{\text{stat}} \pm 0.05_{\text{sys}}) \times 10^{22}\,\mathrm{yr}$ is observed with a statistical significance of $8.3\,\sigma$, in agreement with literature. First empirical measurements of the KK capture fraction relative to other K-shell modes were conducted, and demonstrate consistency with respect to recent signal models at the $1.4\,\sigma$ level., Comment: 15 pages, 3 figures
Published: 2024

2. Probing the Scalar WIMP-Pion Coupling with the first LUX-ZEPLIN data

Author: Aalbers, J., Akerib, D. S., Musalhi, A. K. Al, Alder, F., Amarasinghe, C. S., Ames, A., Anderson, T. J., Angelides, N., Araújo, H. M., Armstrong, J. E., Arthurs, M., Baker, A., Balashov, S., Bang, J., Barillier, E. E., Bargemann, J. W., Beattie, K., Benson, T., Bhatti, A., Biekert, A., Biesiadzinski, T. P., Birch, H. J., Bishop, E. J., Blockinger, G. M., Boxer, B., Brew, C. A. J., Brás, P., Burdin, S., Buuck, M., Carmona-Benitez, M. C., Carter, M., Chawla, A., Chen, H., Cherwinka, J. J., Chin, Y. T., Chott, N. I., Converse, M. V., Cottle, A., Cox, G., Curran, D., Dahl, C. E., David, A., Delgaudio, J., Dey, S., deViveiros, L., DiFelice, L., Ding, C., Dobson, J. E. Y., Druszkiewicz, E., Eriksen, S. R., Fan, A., Fearon, N. M., Fiorucci, S., Flaecher, H., Fraser, E. D., Fruth, T. M. A., Gaitskell, R. J., Geffre, A., Genovesi, J., Ghag, C., Gibbons, R., Gokhale, S., Green, J., vanderGrinten, M. G. D., Haiston, J. J., Hall, C. R., Han, S., Hartigan-O'Connor, E., Haselschwardt, S. J., Hernandez, M. A., Hertel, S. A., Heuermann, G., Homenides, G. J., Horn, M., Huang, D. Q., Hunt, D., Jacquet, E., James, R. S., Johnson, J., Kaboth, A. C., Kamaha, A. C., Kannichankandy, M., Khaitan, D., Khazov, A., Khurana, I., DKim, J., Kim, J., Kingston, J., Kirk, R., Kodroff, D., Korley, L., Korolkova, E. V., Kraus, H., Kravitz, S., Kreczko, L., Kudryavtsev, V. A., Leonard, D. S., Lesko, K. T., Levy, C., Lin, J., Lindote, A., Linehan, R., Lippincott, W. H., Lopes, M. I., Lorenzon, W., Lu, C., Luitz, S., Majewski, P. A., Manalaysay, A., Mannino, R. L., Maupin, C., McCarthy, M. E., McDowell, G., McKinsey, D. N., McLaughlin, J., McLaughlin, J. B., McMonigle, R., Miller, E. H., Mizrachi, E., Monte, A., Monzani, M. E., Mendoza, J. D. Morales, Morrison, E., Mount, B. J., Murdy, M., Murphy, A. St. J., Naylor, A., Nelson, H. N., Neves, F., Nguyen, A., Nikoleyczik, J. A., Olcina, I., Oliver-Mallory, K. C., Orpwood, J., Palladino, K. J., Palmer, J., Pannifer, N. J., Parveen, N., Patton, S. J., Penning, B., Pereira, G., Perry, E., Pershing, T., Piepke, A., Qie, Y., Reichenbacher, J., Rhyne, C. A., Riffard, Q., Rischbieter, G. R. C., Riyat, H. S., Rosero, R., Rushton, T., Rynders, D., Santone, D., Sazzad, A. B. M. R., Schnee, R. W., Shaw, S., Shutt, T., Silk, J. J., Silva, C., Sinev, G., Siniscalco, J., Smith, R., Solovov, V. N., Sorensen, P., Soria, J., Stancu, I., Stevens, A., Stifter, K., Suerfu, B., Sumner, T. J., Szydagis, M., Taylor, W. C., Tiedt, D. R., Timalsina, M., Tong, Z., Tovey, D. R., Tranter, J., Trask, M., Tripathi, M., Tronstad, D. R., Vacheret, A., Vaitkus, A. C., Valentino, O., Velan, V., Wang, A., Wang, J. J., Wang, Y., Watson, J. R., Webb, R. C., Weeldreyer, L., Whitis, T. J., Williams, M., Wisniewski, W. J., Wolfs, F. L. H., Woodford, S., Woodward, D., Wright, C. J., Xia, Q., Xiang, X., Xu, J., Yeh, M., and Zweig, E. A.
Subjects: High Energy Physics - Experiment
Abstract: Weakly interacting massive particles (WIMPs) may interact with a virtual pion that is exchanged between nucleons. This interaction channel is important to consider in models where the spin-independent isoscalar channel is suppressed. Using data from the first science run of the LUX-ZEPLIN dark matter experiment, containing 60 live days of data in a 5.5~tonne fiducial mass of liquid xenon, we report the results on a search for WIMP-pion interactions. We observe no significant excess and set an upper limit of $1.5\times10^{-46}$~cm$^2$ at a 90\% confidence level for a WIMP mass of 33~GeV/c$^2$ for this interaction.
Published: 2024
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3. The Data Acquisition System of the LZ Dark Matter Detector: FADR

Author: Aalbers, J., Akerib, D. S., Musalhi, A. K. Al, Alder, F., Amarasinghe, C. S., Ames, A., Anderson, T. J., Angelides, N., Araújo, H. M., Armstrong, J. E., Arthurs, M., Baker, A., Balashov, S., Bang, J., Barillier, E. E., Bargemann, J. W., Beattie, K., Benson, T., Bhatti, A., Biekert, A., Biesiadzinski, T. P., Birch, H. J., Bishop, E., Blockinger, G. M., Boxer, B., Brew, C. A. J., Brás, P., Buckley, J. H., Burdin, S., Buuck, M., Carmona-Benitez, M. C., Carter, M., Chawla, A., Chen, H., Cherwinka, J. J., Chin, Y. T., Chott, N. I., Converse, M. V., Cottle, A., Cox, G., Curran, D., Dahl, C. E., David, A., Delgaudio, J., Dey, S., de Viveiros, L., Di Felice, L., Dimino, T., Ding, C., Dobson, J. E. Y., Druszkiewicz, E., Eriksen, S. R., Fan, A., Fearon, N. M., Fieldhouse, N., Fiorucci, S., Flaecher, H., Fraser, E. D., Fruth, T. M. A., Gaitskell, R. J., Geffre, A., Gelfand, R., Genovesi, J., Ghag, C., Gibbons, R., Gokhale, S., Green, J., van der Grinten, M. G. D., Haiston, J. J., Hall, C. R., Han, S., Hartigan-O'Connor, E., Haselschwardt, S. J., Hernandez, M. A., Hertel, S. A., Heuermann, G., Homenides, G. J., Horn, M., Huang, D. Q., Hunt, D., Jacquet, E., James, R. S., Johnson, J., Kaboth, A. C., Kamaha, A. C., Kannichankandy, M., Khaitan, D., Khazov, A., Khurana, I., Kim, J., Kim, Y. D., Kingston, J., Kirk, R., Kodroff, D., Korley, L., Korolkova, E. V., Koyuncu, M., Kraus, H., Kravitz, S., Kreczko, L., Kudryavtsev, V. A., Leonard, D. S., Lesko, K. T., Levy, C., Lin, J., Lindote, A., Linehan, R., Lippincott, W. H., Loniewski, C., Lopes, M. I., Lorenzon, W., Lu, C., Luitz, S., Majewski, P. A., Manalaysay, A., Mannino, R. L., Maupin, C., McCarthy, M. E., McDowell, G., McKinsey, D. N., McLaughlin, J., Mclaughlin, J. B., McMonigle, R., Miller, E. H., Mizrachi, E., Monte, A., Monzani, M. E., Moongweluwan, M., Mendoza, J. D. Morales, Morrison, E., Mount, B. J., Murdy, M., Murphy, A. St. J., Naylor, A., Nelson, H. N., Neves, F., Nguyen, A., Nikoleyczik, J. A., Oh, H., Olcina, I., Olevitch, M. A., Oliver-Mallory, K. C., Orpwood, J., Palladino, K. J., Palmer, J., Pannifer, N. J., Parveen, N., Patton, S. J., Penning, B., Pereira, G., Perry, E., Pershing, T., Piepke, A., Qie, Y., Reichenbacher, J., Rhyne, C. A., Riffard, Q., Rischbieter, G. R. C., Riyat, H. S., Rosero, R., Rushton, T., Rynders, D., Santone, D., Sarkis, R., Sazzad, A. B. M. R., Schnee, R. W., Shaw, S., Shutt, T., Silk, J. J., Silva, C., Sinev, G., Siniscalco, J., Skulski, W., Smith, R., Solovov, V. N., Sorensen, P., Soria, J., Stancu, I., Stevens, A., Stifter, K., Suerfu, B., Sumner, T. J., Szydagis, M., Taylor, W. C., Tiedt, D. R., Timalsina, M., Tong, Z., Tovey, D. R., Tranter, J., Trask, M., Tripathi, M., Tronstad, D. R., Vacheret, A., Vaitkus, A. C., Vaitkus, J., Valentino, O., Velan, V., Wang, A., Wang, J. J., Wang, Y., Watson, J. R., Webb, R. C., Weeldreyer, L., Whitis, T. J., Williams, M., Wisniewski, W. J., Wolfs, F. L. H., Wolfs, J. D., Woodford, S., Woodward, D., Wright, C. J., Xia, Q., Xiang, X., Xu, J., Yeh, M., and Yin, J.
Subjects: Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract: The Data Acquisition System (DAQ) for the LUX-ZEPLIN (LZ) dark matter detector is described. The signals from 745 PMTs, distributed across three subsystems, are sampled with 100-MHz 32-channel digitizers (DDC-32s). A basic waveform analysis is carried out on the on-board Field Programmable Gate Arrays (FPGAs) to extract information about the observed scintillation and electroluminescence signals. This information is used to determine if the digitized waveforms should be preserved for offline analysis. The system is designed around the Kintex-7 FPGA. In addition to digitizing the PMT signals and providing basic event selection in real time, the flexibility provided by the use of FPGAs allows us to monitor the performance of the detector and the DAQ in parallel to normal data acquisition. The hardware and software/firmware of this FPGA-based Architecture for Data acquisition and Realtime monitoring (FADR) are discussed and performance measurements are described., Comment: 18 pages, 24 figures
Published: 2024

4. The Design, Implementation, and Performance of the LZ Calibration Systems

Author: Aalbers, J., Akerib, D. S., Musalhi, A. K. Al, Alder, F., Amarasinghe, C. S., Ames, A., Anderson, T. J., Angelides, N., Araújo, H. M., Armstrong, J. E., Arthurs, M., Baker, A., Balashov, S., Bang, J., Barillier, E. E., Bargemann, J. W., Beattie, K., Benson, T., Bhatti, A., Biekert, A., Biesiadzinski, T. P., Birch, H. J., Bishop, E., Blockinger, G. M., Boxer, B., Brew, C. A. J., Brás, P., Burdin, S., Buuck, M., Carmona-Benitez, M. C., Carter, M., Chawla, A., Chen, H., Cherwinka, J. J., Chin, Y. T., Chott, N. I., Converse, M. V., Cottle, A., Cox, G., Curran, D., Dahl, C. E., David, A., Delgaudio, J., Dey, S., de Viveiros, L., Di Felice, L., Ding, C., Dobson, J. E. Y., Druszkiewicz, E., Eriksen, S. R., Fan, A., Fearon, N. M., Fieldhouse, N., Fiorucci, S., Flaecher, H., Fraser, E. D., Fruth, T. M. A., Gaitskell, R. J., Geffre, A., Genovesi, J., Ghag, C., Gibbons, R., Gokhale, S., Green, J., van der Grinten, M. G. D., Haiston, J. J., Hall, C. R., Han, S., Hartigan-O'Connor, E., Haselschwardt, S. J., Hernandez, M. A., Hertel, S. A., Heuermann, G., Homenides, G. J., Horn, M., Huang, D. Q., Hunt, D., Jacquet, E., James, R. S., Johnson, J., Kaboth, A. C., Kamaha, A. C., Kannichankandy, M., Khaitan, D., Khazov, A., Khurana, I., Kim, J., Kim, Y. D., Kingston, J., Kirk, R., Kodroff, D., Korley, L., Korolkova, E. V., Kraus, H., Kravitz, S., Kreczko, L., Kudryavtsev, V. A., Leonard, D. S., Lesko, K. T., Levy, C., Lin, J., Lindote, A., Linehan, R., Lippincott, W. H., Lopes, M. I., Lorenzon, W., Lu, C., Luitz, S., Majewski, P. A., Manalaysay, A., Mannino, R. L., Maupin, C., McCarthy, M. E., McDowell, G., McKinsey, D. N., McLaughlin, J., Mclaughlin, J. B., McMonigle, R., Miller, E. H., Mizrachi, E., Monte, A., Monzani, M. E., Mendoza, J. D. Morales, Morrison, E., Mount, B. J., Murdy, M., Murphy, A. St. J., Naylor, A., Nelson, H. N., Neves, F., Nguyen, A., Nikoleyczik, J. A., Olcina, I., Oliver-Mallory, K. C., Orpwood, J., Palladino, K. J., Palmer, J., Pannifer, N. J., Parveen, N., Patton, S. J., Penning, B., Pereira, G., Perry, E., Pershing, T., Piepke, A., Qie, Y., Reichenbacher, J., Rhyne, C. A., Riffard, Q., Rischbieter, G. R. C., Riyat, H. S., Rosero, R., Rushton, T., Rynders, D., Santone, D., Sazzad, A. B. M. R., Schnee, R. W., Shaw, S., Shutt, T., Silk, J. J., Silva, C., Sinev, G., Siniscalco, J., Smith, R., Solovov, V. N., Sorensen, P., Soria, J., Stancu, I., Stevens, A., Stifter, K., Suerfu, B., Sumner, T. J., Szydagis, M., Taylor, W. C., Tiedt, D. R., Timalsina, M., Tong, Z., Tovey, D. R., Tranter, J., Trask, M., Tripathi, M., Tronstad, D. R., Vacheret, A., Vaitkus, A. C., Valentino, O., Velan, V., Wang, A., Wang, J. J., Wang, Y., Watson, J. R., Webb, R. C., Weeldreyer, L., Whitis, T. J., Williams, M., Wisniewski, W. J., Wolfs, F. L. H., Woodford, S., Woodward, D., Wright, C. J., Xia, Q., Xiang, X., Xu, J., and Yeh, M.
Subjects: Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract: LUX-ZEPLIN (LZ) is a tonne-scale experiment searching for direct dark matter interactions and other rare events. It is located at the Sanford Underground Research Facility (SURF) in Lead, South Dakota, USA. The core of the LZ detector is a dual-phase xenon time projection chamber (TPC), designed with the primary goal of detecting Weakly Interacting Massive Particles (WIMPs) via their induced low energy nuclear recoils. Surrounding the TPC, two veto detectors immersed in an ultra-pure water tank enable reducing background events to enhance the discovery potential. Intricate calibration systems are purposely designed to precisely understand the responses of these three detector volumes to various types of particle interactions and to demonstrate LZ's ability to discriminate between signals and backgrounds. In this paper, we present a comprehensive discussion of the key features, requirements, and performance of the LZ calibration systems, which play a crucial role in enabling LZ's WIMP-search and its broad science program. The thorough description of these calibration systems, with an emphasis on their novel aspects, is valuable for future calibration efforts in direct dark matter and other rare-event search experiments.
Published: 2024
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5. Probing the scalar WIMP-pion coupling with the first LUX-ZEPLIN data

Author: Zweig, EA, Yeh, M, Xu, J, Xiang, X, Xia, Q, Wright, CJ, Woodward, D, Woodford, S, Wolfs, FLH, Wisniewski, WJ, Williams, M, Whitis, TJ, Weeldreyer, L, Webb, RC, Watson, JR, Wang, Y, Wang, JJ, Wang, A, Velan, V, Valentino, O, Vaitkus, AC, Vacheret, A, Tronstad, DR, Tripathi, M, Trask, M, Tranter, J, Tovey, DR, Tong, Z, Timalsina, M, Tiedt, DR, Taylor, WC, Szydagis, M, Sumner, TJ, Suerfu, B, Stifter, K, Stevens, A, Stancu, I, Soria, J, Sorensen, P, Solovov, VN, Smith, R, Siniscalco, J, Sinev, G, Silva, C, Silk, JJ, Shutt, T, Shaw, S, Schnee, RW, Sazzad, ABMR, Santone, D, Rynders, D, Rushton, T, Rosero, R, Riyat, HS, Rischbieter, GRC, Riffard, Q, Rhyne, CA, Reichenbacher, J, Qie, Y, Piepke, A, Pershing, T, Perry, E, Pereira, G, Penning, B, Patton, SJ, Parveen, N, Pannifer, NJ, Palmer, J, Palladino, KJ, Orpwood, J, Oliver-Mallory, KC, Olcina, I, Nikoleyczik, JA, Nguyen, A, Neves, F, Nelson, HN, Naylor, A, Murphy, ASJ, Murdy, M, Mount, BJ, Morrison, E, Morales Mendoza, JD, Monzani, ME, Monte, A, Mizrachi, E, Miller, EH, McMonigle, R, McLaughlin, JB, McLaughlin, J, McKinsey, DN, McDowell, G, McCarthy, ME, Maupin, C, Mannino, RL, Manalaysay, A, Majewski, PA, Luitz, S, Lu, C, Lorenzon, W, and Lopes, MI
Subjects: Nuclear and Plasma Physics, Particle and High Energy Physics, Physical Sciences, Engineering, Mathematical sciences, Physical sciences
Abstract: Weakly interacting massive particles (WIMPs) may interact with a virtual pion that is exchanged between nucleons. This interaction channel is important to consider in models where the spin-independent isoscalar channel is suppressed. Using data from the first science run of the LUX-ZEPLIN dark matter experiment, containing 60 live days of data in a 5.5 tonne fiducial mass of liquid xenon, we report the results on a search for WIMP-pion interactions. We observe no significant excess and set an upper limit of 1.5 × 10−46 cm2 at a 90% confidence level for a WIMP mass of 33 GeV/c2 for this interaction.
Published: 2024

6. Constraints On Covariant WIMP-Nucleon Effective Field Theory Interactions from the First Science Run of the LUX-ZEPLIN Experiment

Author: Aalbers, J., Akerib, D. S., Musalhi, A. K. Al, Alder, F., Amarasinghe, C. S., Ames, A., Anderson, T. J., Angelides, N., Araújo, H. M., Armstrong, J. E., Arthurs, M., Baker, A., Balashov, S., Bang, J., Barillier, E. E., Bargemann, J. W., Beattie, K., Benson, T., Bhatti, A., Biekert, A., Biesiadzinski, T. P., Birch, H. J., Bishop, E. J., Blockinger, G. M., Boxer, B., Brew, C. A. J., Brás, P., Burdin, S., Buuck, M., Carmona-Benitez, M. C., Carter, M., Chawla, A., Chen, H., Cherwinka, J. J., Chin, Y. T., Chott, N. I., Converse, M. V., Cottle, A., Cox, G., Curran, D., Dahl, C. E., David, A., Delgaudio, J., Dey, S., de Viveiros, L., Di Felice, L., Ding, C., Dobson, J. E. Y., Druszkiewicz, E., Eriksen, S. R., Fan, A., Fearon, N. M., Fiorucci, S., Flaecher, H., Fraser, E. D., Fruth, T. M. A., Gaitskell, R. J., Geffre, A., Genovesi, J., Ghag, C., Gibbons, R., Gokhale, S., Green, J., van der Grinten, M. G. D., Haiston, J. H., Hall, C. R., Han, S., Hartigan-O'Connor, E., Haselschwardt, S. J., Hernandez, M. A., Hertel, S. A., Heuermann, G., Homenides, G. J., Horn, M., Huang, D. Q., Hunt, D., Ignarra, C. M., Jacquet, E., James, R. S., Johnson, J., Kaboth, A. C., Kamaha, A. C., Kannichankandy, M., Khaitan, D., Khazov, A., Khurana, I., Kim, J., Kingston, J., Kirk, R., Kodroff, D., Korley, L., Korolkova, E. V., Kraus, H., Kravitz, S., Kreczko, L., Kudryavtsev, V. A., Lee, J., Leonard, D. S., Lesko, K. T., Levy, C., Lin, J., Lindote, A., Linehan, R., Lippincott, W. H., Lopes, M. I., Lorenzon, W., Lu, C., Luitz, S., Majewski, P. A., Manalaysay, A., Mannino, R. L., Maupin, C., McCarthy, M. E., McDowell, G., McKinsey, D. N., McLaughlin, J., McLaughlin, J. B., McMonigle, R., Miller, E. H., Mizrachi, E., Monte, A., Monzani, M. E., Mendoza, J. D. Morales, Morrison, E., Mount, B. J., Murdy, M., Murphy, A. St. J., Naylor, A., Nelson, H. N., Neves, F., Nguyen, A., Nikoleyczik, J. A., Olcina, I., Oliver-Mallory, K. C., Orpwood, J., Palladino, K. J., Palmer, J., Pannifer, N. J., Parveen, N., Patton, S. J., Penning, B., Pereira, G., Perry, E., Pershing, T., Piepke, A., Qie, Y., Reichenbacher, J., Rhyne, C. A., Riffard, Q., Rischbieter, G. R. C., Riyat, H. S., Rosero, R., Rushton, T., Rynders, D., Santone, D., Sazzad, A. B. M. R., Schnee, R. W., Shaw, S., Shutt, T., Silk, J. J., Silva, C., Sinev, G., Siniscalco, J., Smith, R., Solovov, V. N., Sorensen, P., Soria, J., Stancu, I., Stevens, A., Stifter, K., Suerfu, B., Sumner, T. J., Szydagis, M., Taylor, W. C., Tiedt, D. R., Timalsina, M., Tong, Z., Tovey, D. R., Tranter, J., Trask, M., Tripathi, M., Tronstad, D. R., Vacheret, A., Vaitkus, A. C., Valentino, O., Velan, V., Wang, A., Wang, J. J., Wang, Y., Watson, J. R., Webb, R. C., Weeldreyer, L., Whitis, T. J., Williams, M., Wisniewski, W. J., Wolfs, F. L. H., Woodford, S., Woodward, D., Wright, C. J., Xia, Q., Xiang, X., Xu, J., Yeh, M., and Zweig, E. A.
Subjects: High Energy Physics - Experiment
Abstract: The first science run of the LUX-ZEPLIN (LZ) experiment, a dual-phase xenon time project chamber operating in the Sanford Underground Research Facility in South Dakota, USA, has reported leading limits on spin-independent WIMP-nucleon interactions and interactions described from a non-relativistic effective field theory (NREFT). Using the same 5.5~t fiducial mass and 60 live days of exposure we report on the results of a relativistic extension to the NREFT. We present constraints on couplings from covariant interactions arising from the coupling of vector, axial currents, and electric dipole moments of the nucleon to the magnetic and electric dipole moments of the WIMP which cannot be described by recasting previous results described by an NREFT. Using a profile-likelihood ratio analysis, in an energy region between 0~keV$_\text{nr}$ to 270~keV$_\text{nr}$, we report 90% confidence level exclusion limits on the coupling strength of five interactions in both the isoscalar and isovector bases., Comment: 7 pages, 4 figures
Published: 2024

7. New constraints on ultraheavy dark matter from the LZ experiment

Author: Aalbers, J., Akerib, D. S., Musalhi, A. K. Al, Amarasinghe, C. S., Ames, A., Anderson, T. J., Angelides, N., Araújo, H. M., Armstrong, J. E., Arthurs, M., Baker, A., Balashov, S., Bang, J., Bargemann, J. W., Baxter, A., Beattie, K., Benson, T., Bhatti, A., Biekert, A., Biesiadzinski, T. P., Birch, H. J., Bishop, E., Blockinger, G. M., Boxer, B., Brew, C. A. J., Brás, P., Burdin, S., Buuck, M., Carmona-Benitez, M. C., Carter, M., Chawla, A., Chen, H., Cherwinka, J. J., Chott, N. I., Converse, M. V., Cottle, A., Cox, G., Curran, D., Dahl, C. E., David, A., Delgaudio, J., Dey, S., de Viveiros, L., Ding, C., Dobson, J. E. Y., Druszkiewicz, E., Eriksen, S. R., Fan, A., Fearon, N. M., Fiorucci, S., Flaecher, H., Fraser, E. D., Fruth, T. M. A., Gaitskell, R. J., Geffre, A., Genovesi, J., Ghag, C., Gibbons, R., Gokhale, S., Green, J., van der Grinten, M. G. D., Hall, C. R., Han, S., Hartigan-O'Connor, E., Haselschwardt, S. J., Hertel, S. A., Heuermann, G., Homenides, G. J., Horn, M., Huang, D. Q., Hunt, D., Ignarra, C. M., Jacquet, E., James, R. S., Johnson, J., Kaboth, A. C., Kamaha, A. C., Khaitan, D., Khazov, A., Khurana, I., Kim, J., Kingston, J., Kirk, R., Kodroff, D., Korley, L., Korolkova, E. V., Kraus, H., Kravitz, S., Kreczko, L., Krikler, B., Kudryavtsev, V. A., Lee, J., Leonard, D. S., Lesko, K. T., Levy, C., Lin, J., Lindote, A., Linehan, R., Lippincott, W. H., Lopes, M. I., Asamar, E. Lopez, Lorenzon, W., Lu, C., Luitz, S., Majewski, P. A., Manalaysay, A., Mannino, R. L., Maupin, C., McCarthy, M. E., McDowell, G., McKinsey, D. N., McLaughlin, J., McMonigle, R., Miller, E. H., Mizrachi, E., Monte, A., Monzani, M. E., Mendoza, J. D. Morales, Morrison, E., Mount, B. J., Murdy, M., Murphy, A. St. J., Naylor, A., Nedlik, C., Nelson, H. N., Neves, F., Nguyen, A., Nikoleyczik, J. A., Olcina, I., Oliver-Mallory, K. C., Orpwood, J., Palladino, K. J., Palmer, J., Pannifer, N. J., Parveen, N., Patton, S. J., Penning, B., Pereira, G., Perry, E., Pershing, T., Piepke, A., Qie, Y., Reichenbacher, J., Rhyne, C. A., Riffard, Q., Rischbieter, G. R. C., Riyat, H. S., Rosero, R., Rushton, T., Rynders, D., Santone, D., Sazzad, A. B. M. R., Schnee, R. W., Shaw, S., Shutt, T., Silk, J. J., Silva, C., Sinev, G., Smith, R., Solovov, V. N., Sorensen, P., Soria, J., Stancu, I., Stevens, A., Stifter, K., Suerfu, B., Sumner, T. J., Szydagis, M., Taylor, W. C., Tiedt, D. R., Timalsina, M., Tong, Z., Tovey, D. R., Tranter, J., Trask, M., Tripathi, M., Tronstad, D. R., Turner, W., Vacheret, A., Vaitkus, A. C., Velan, V., Wang, A., Wang, J. J., Wang, Y., Watson, J. R., Webb, R. C., Weeldreyer, L., Whitis, T. J., Williams, M., Wisniewski, W. J., Wolfs, F. L. H., Woodford, S., Woodward, D., Wright, C. J., Xia, Q., Xiang, X., Xu, J., Yeh, M., and Zweig, E. A.
Subjects: High Energy Physics - Experiment, Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract: Searches for dark matter with liquid xenon time projection chamber experiments have traditionally focused on the region of the parameter space that is characteristic of weakly interacting massive particles, ranging from a few GeV/$c^2$ to a few TeV/$c^2$. Models of dark matter with a mass much heavier than this are well motivated by early production mechanisms different from the standard thermal freeze-out, but they have generally been less explored experimentally. In this work, we present a re-analysis of the first science run (SR1) of the LZ experiment, with an exposure of $0.9$ tonne$\times$year, to search for ultraheavy particle dark matter. The signal topology consists of multiple energy deposits in the active region of the detector forming a straight line, from which the velocity of the incoming particle can be reconstructed on an event-by-event basis. Zero events with this topology were observed after applying the data selection calibrated on a simulated sample of signal-like events. New experimental constraints are derived, which rule out previously unexplored regions of the dark matter parameter space of spin-independent interactions beyond a mass of 10$^{17}$ GeV/$c^2$., Comment: 9 pages, 7 figures
Published: 2024
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8. First Constraints on WIMP-Nucleon Effective Field Theory Couplings in an Extended Energy Region From LUX-ZEPLIN

Author: LZ Collaboration, Aalbers, J., Akerib, D. S., Musalhi, A. K. Al, Alder, F., Amarasinghe, C. S., Ames, A., Anderson, T. J., Angelides, N., Araújo, H. M., Armstrong, J. E., Arthurs, M., Baker, A., Balashov, S., Bang, J., Bargemann, J. W., Baxter, A., Beattie, K., Benson, T., Bhatti, A., Biekert, A., Biesiadzinski, T. P., Birch, H. J., Bishop, E., Blockinger, G. M., Boxer, B., Brew, C. A. J., Brás, P., Burdin, S., Buuck, M., Carmona-Benitez, M. C., Carter, M., Chawla, A., Chen, H., Cherwinka, J. J., Chott, N. I., Converse, M. V., Cottle, A., Cox, G., Curran, D., Dahl, C. E., David, A., Delgaudio, J., Dey, S., de Viveiros, L., Ding, C., Dobson, J. E. Y., Druszkiewicz, E., Eriksen, S. R., Fan, A., Fearon, N. M., Fiorucci, S., Flaecher, H., Fraser, E. D., Fruth, T. M. A., Gaitskell, R. J., Geffre, A., Genovesi, J., Ghag, C., Gibbons, R., Gokhale, S., Green, J., van der Grinten, M. G. D., Hall, C. R., Han, S., Hartigan-O'Connor, E., Haselschwardt, S. J., Hertel, S. A., Heuermann, G., Homenides, G. J., Horn, M., Huang, D. Q., Hunt, D., Ignarra, C. M., Jacquet, E., James, R. S., Johnson, J., Kaboth, A. C., Kamaha, A. C., Khaitan, D., Khazov, A., Khurana, I., Kim, J., Kingston, J., Kirk, R., Kodroff, D., Korley, L., Korolkova, E. V., Kraus, H., Kravitz, S., Kreczko, L., Krikler, B., Kudryavtsev, V. A., Lee, J., Leonard, D. S., Lesko, K. T., Levy, C., Lin, J., Lindote, A., Linehan, R., Lippincott, W. H., Lopes, M. I., Asamar, E. Lopez, Lorenzon, W., Lu, C., Luitz, S., Majewski, P. A., Manalaysay, A., Mannino, R. L., Maupin, C., McCarthy, M. E., McDowell, G., McKinsey, D. N., McLaughlin, J., Miller, E. H., Mizrachi, E., Monte, A., Monzani, M. E., Mendoza, J. D. Morales, Morrison, E., Mount, B. J., Murdy, M., Murphy, A. St. J., Naylor, A., Nedlik, C., Nelson, H. N., Neves, F., Nguyen, A., Nikoleyczik, J. A., Olcina, I., Oliver-Mallory, K. C., Orpwood, J., Palladino, K. J., Palmer, J., Pannifer, N., Parveen, N., Patton, S. J., Penning, B., Pereira, G., Perry, E., Pershing, T., Piepke, A., Qie, Y., Reichenbacher, J., Rhyne, C. A., Riffard, Q., Rischbieter, G. R. C., Riyat, H. S., Rosero, R., Rushton, T., Rynders, D., Santone, D., Sazzad, A. B. M. R., Schnee, R. W., Shaw, S., Shutt, T., Silk, J. J., Silva, C., Sinev, G., Smith, R., Solovov, V. N., Sorensen, P., Soria, J., Stancu, I., Stevens, A., Stifter, K., Suerfu, B., Sumner, T. J., Szydagis, M., Taylor, W. C., Tiedt, D. R., Timalsina, M., Tong, Z., Tovey, D. R., Tranter, J., Trask, M., Tripathi, M., Tronstad, D. R., Turner, W., Vacheret, A., Vaitkus, A. C., Velan, V., Wang, A., Wang, J. J., Wang, Y., Watson, J. R., Webb, R. C., Weeldreyer, L., Whitis, T. J., Williams, M., Wisniewski, W. J., Wolfs, F. L. H., Woodford, S., Woodward, D., Wright, C. J., Xia, Q., Xiang, X., Xu, J., Yeh, M., and Zweig, E. A.
Subjects: High Energy Physics - Experiment, Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract: Following the first science results of the LUX-ZEPLIN (LZ) experiment, a dual-phase xenon time projection chamber operating from the Sanford Underground Research Facility in Lead, South Dakota, USA, we report the initial limits on a model-independent non-relativistic effective field theory describing the complete set of possible interactions of a weakly interacting massive particle (WIMP) with a nucleon. These results utilize the same 5.5 t fiducial mass and 60 live days of exposure collected for the LZ spin-independent and spin-dependent analyses while extending the upper limit of the energy region of interest by a factor of 7.5 to 270 keVnr. No significant excess in this high energy region is observed. Using a profile-likelihood ratio analysis, we report 90% confidence level exclusion limits on the coupling of each individual non-relativistic WIMP-nucleon operator for both elastic and inelastic interactions in the isoscalar and isovector bases., Comment: 17 pages 11 figures
Published: 2023
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9. The Values of PDK1 and LDH Levels in Patients with Sepsis and Septic Shock: A Prospective Observational Study

Author: Liu J, Zhou G, Tong Z, Wang X, and Liu D
Subjects: sepsis, septic shock, pdk1/ldh, metabolic reprogramming, mortality, Pathology, RB1-214, Therapeutics. Pharmacology, RM1-950
Abstract: Jingjing Liu, Gaosheng Zhou, Zewen Tong, Xiaoting Wang, Dawei Liu Department of Critical Care Medicine, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, People’s Republic of ChinaCorrespondence: Dawei Liu, Department of Critical Care Medicine, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, 1&num; Shuai Fu Yuan, Dong Cheng District, Beijing, 100730, People’s Republic of China, Tel +86-10-69152305, Email daweiliu05@163.comBackground: Metabolic changing is the significant host stress response during sepsis, but there is increasing evidence that uncontrolled metabolic reprogramming is a contributing factor to sepsis. Nevertheless, its association with outcome in patients with sepsis has been poorly investigated. As the key enzyme of metabolic reprogramming, the clinical value of PDK1 and LDH in patients with sepsis will be investigated in this study.Methods: We collected serum from 167 ICU patients within 24 hours of admission for a single-center prospective observational study. The levels of PDK1 and LDH were detected by enzyme-linked adsorption method. Pearson or Spearman coefficient for correlation analysis between PDK1, LDH and clinical indicators. Areas under the ROC curves for evaluation of mortality prediction. Kaplan–Meier survival curve analysis was performed, and Cox proportional hazards model was performed to determine the risk factors for 28-day mortality.Results: The PDK1/LDH in the septic shock group was statistically different between both the sepsis group and ICU control group, and had good correlation with ScvO2 and lactate. In predicting 28-day mortality in patients with sepsis, the best AUC was observed for PDK1/LDH, and was higher than the AUC for PDK1, lactate, and SOFA. Additionally, patients with lower PDK1/LDH had markerablely higher 28-day mortality. The multivariate Cox proportional hazards model revealed that PDK1/LDH < 0.1808 were the independent risk factors for 28-day mortality in sepsis.Conclusion: The level of PDK1/LDH at admission was markedly decreased in patients with septic shock, which can serve as a novel independent prognostic biomarker for predicting mortality.Keywords: sepsis, septic shock, PDK1/LDH, metabolic reprogramming, mortality
Published: 2024

10. A search for new physics in low-energy electron recoils from the first LZ exposure

Author: The LZ Collaboration, Aalbers, J., Akerib, D. S., Musalhi, A. K. Al, Alder, F., Amarasinghe, C. S., Ames, A., Anderson, T. J., Angelides, N., Araújo, H. M., Armstrong, J. E., Arthurs, M., Baker, A., Balashov, S., Bang, J., Bargemann, J. W., Baxter, A., Beattie, K., Beltrame, P., Benson, T., Bhatti, A., Biekert, A., Biesiadzinski, T. P., Birch, H. J., Blockinger, G. M., Boxer, B., Brew, C. A. J., Brás, P., Burdin, S., Buuck, M., Carmona-Benitez, M. C., Chan, C., Chawla, A., Chen, H., Cherwinka, J. J., Chott, N. I., Converse, M. V., Cottle, A., Cox, G., Curran, D., Dahl, C. E., David, A., Delgaudio, J., Dey, S., de Viveiros, L., Ding, C., Dobson, J. E. Y., Druszkiewicz, E., Eriksen, S. R., Fan, A., Fearon, N. M., Fiorucci, S., Flaecher, H., Fraser, E. D., Fruth, T. M. A., Gaitskell, R. J., Geffre, A., Genovesi, J., Ghag, C., Gibbons, R., Gokhale, S., Green, J., van der Grinten, M. G. D., Hall, C. R., Han, S., Hartigan-O'Connor, E., Haselschwardt, S. J., Huang, D. Q., Hertel, S. A., Heuermann, G., Horn, M., Hunt, D., Ignarra, C. M., Jahangir, O., James, R. S., Johnson, J., Kaboth, A. C., Kamaha, A. C., Khaitan, D., Khazov, A., Khurana, I., Kim, J., Kingston, J., Kirk, R., Kodroff, D., Korley, L., Korolkova, E. V., Kraus, H., Kravitz, S., Kreczko, L., Krikler, B., Kudryavtsev, V. A., Leason, E. A., Lee, J., Leonard, D. S., Lesko, K. T., Levy, C., Lin, J., Lindote, A., Linehan, R., Lippincott, W. H., Liu, X., Lopes, M. I., Asamar, E. Lopez, Lorenzon, W., Lu, C., Lucero, D., Luitz, S., Majewski, P. A., Manalaysay, A., Mannino, R. L., Maupin, C., McCarthy, M. E., McDowell, G., McKinsey, D. N., McLaughlin, J., Miller, E. H., Mizrachi, E., Monte, A., Monzani, M. E., Mendoza, J. D. Morales, Morrison, E., Mount, B. J., Murdy, M., Murphy, A. St. J., Naim, D., Naylor, A., Nedlik, C., Nelson, H. N., Neves, F., Nguyen, A., Nikoleyczik, J. A., Olcina, I., Oliver-Mallory, K. C., Orpwood, J., Palladino, K. J., Palmer, J., Parveen, N., Patton, S. J., Penning, B., Pereira, G., Perry, E., Pershing, T., Piepke, A., Poudel, S., Qie, Y., Reichenbacher, J., Rhyne, C. A., Riffard, Q., Rischbieter, G. R. C., Riyat, H. S., Rosero, R., Rushton, T., Rynders, D., Santone, D., Sazzad, A. B. M. R., Schnee, R. W., Shaw, S., Shutt, T., Silk, J. J., Silva, C., Sinev, G., Smith, R., Solovov, V. N., Sorensen, P., Soria, J., Stancu, I., Stevens, A., Stifter, K., Suerfu, B., Sumner, T. J., Szydagis, M., Taylor, W. C., Temples, D. J., Tiedt, D. R., Timalsina, M., Tong, Z., Tovey, D. R., Tranter, J., Trask, M., Tripathi, M., Tronstad, D. R., Turner, W., Vacheret, A., Vaitkus, A. C., Wang, A., Wang, J. J., Wang, Y., Watson, J. R., Webb, R. C., Weeldreyer, L., Whitis, T. J., Williams, M., Wisniewski, W. J., Wolfs, F. L. H., Woodford, S., Woodward, D., Wright, C. J., Xia, Q., Xiang, X., Xu, J., Yeh, M., and Zweig, E. A.
Subjects: High Energy Physics - Experiment, Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract: The LUX-ZEPLIN (LZ) experiment is a dark matter detector centered on a dual-phase xenon time projection chamber. We report searches for new physics appearing through few-keV-scale electron recoils, using the experiment's first exposure of 60 live days and a fiducial mass of 5.5t. The data are found to be consistent with a background-only hypothesis, and limits are set on models for new physics including solar axion electron coupling, solar neutrino magnetic moment and millicharge, and electron couplings to galactic axion-like particles and hidden photons. Similar limits are set on weakly interacting massive particle (WIMP) dark matter producing signals through ionized atomic states from the Migdal effect., Comment: 13 pages, 10 figures. See https://tinyurl.com/LZDataReleaseRun1ER for a data release related to this paper
Published: 2023
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11. The Relationship Between Insulin Resistance Indicated by Triglyceride and Glucose Index and Left Ventricular Hypertrophy and Decreased Left Ventricular Diastolic Function with Preserved Ejection Fraction

Author: Yang C, Liu W, Tong Z, Lei F, Lin L, Huang X, Zhang X, Sun T, Wu G, Shan H, Chen S, and Li H
Subjects: insulin resistance, triglyceride and glucose index, left ventricular hypertrophy, left ventricular diastolic function, Specialties of internal medicine, RC581-951
Abstract: Chengzhang Yang,1,2,&ast; Weifang Liu,2,3,&ast; Zijia Tong,1,&ast; Fang Lei,3,4 Lijin Lin,2,3 Xuewei Huang,3,5 Xingyuan Zhang,3,6 Tao Sun,2,3 Gang Wu,1 Huajing Shan,1 Shaoze Chen,1 Hongliang Li2,3 1Department of Cardiology, Huanggang Central Hospital, Huanggang, People’s Republic of China; 2Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, People’s Republic of China; 3Institute of Model Animal, Wuhan University, Wuhan, People’s Republic of China; 4Medical Science Research Center, Zhongnan Hospital of Wuhan University, Wuhan, People’s Republic of China; 5Department of Cardiology, The Third Xiangya Hospital, Central South University, Changsha, People’s Republic of China; 6School of Basic Medical Science, Wuhan University, Wuhan, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Hongliang Li, Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, People’s Republic of China, Tel/Fax +86-27-68759302, Email lihl@whu.edu.cn Shaoze Chen, Department of Cardiology, Huanggang Central Hospital, Huanggang, People’s Republic of China, Tel/Fax +86-713-8381191, Email chenshaoze@hgyy.org.cnAim: The evidence on the association between insulin resistance (IR) and the prevalence or incidence of cardiac dysfunction has been controversial, and the relationship between pre-diabetic IR and cardiac function is lacking. Large sample studies in the Chinese general population are urgently needed to explore the association between IR and the risk of left ventricular hypertrophy (LVH) and decreased left ventricular diastolic function with preserved ejection fraction (LVDFpEF).Methods: Based on a National Health Check-up database in China, we conducted a multicenter cross-sectional retrospective study in 344,420 individuals. Furthermore, at a single center, we performed two retrospective longitudinal studies encompassing 8270 and 5827 individuals to investigate the association between IR and the development of new-onset LVH and LVDFpEF, respectively. The median follow-up duration exceeded 2.5 years. The triglyceride and glucose (TyG) index, known for its high sensitivity in detecting IR, serves as a reliable alternative marker of IR. The logistic and cox proportional hazard regression models were used to determine the relationships.Results: In the cross-sectional study, IR showed a positive association with the prevalence of LVH and decreased LVDFpEF after adjusting for confounders. In the longitudinal cohort, IR was also correlated with the new onset of LVH and decreased LVDFpEF, with hazard ratios (HR) of 1.986 (95% CI: 1.307, 3.017) and 1.386 (95% CI: 1.167, 1.647) in the fourth quartile of TyG levels compared to the lowest quartile, respectively, after adjusting for confounders. The subgroup analysis in non-hypertensive or non-diabetic people and the sensitivity analysis in the population with homeostasis model assessment of insulin resistance (HOMA-IR) further verified the above-mentioned results.Conclusion: IR was associated with LVH and decreased LVDFpEF. Effective management of IR may prevent or delay the development of adverse LVH and decreased LVDFpEF.Keywords: insulin resistance, triglyceride and glucose index, left ventricular hypertrophy, left ventricular diastolic function
Published: 2024

12. Clinical Characteristics and Prognostic Predictors of Pneumocystis Jirovecii Pneumonia in Patients with and without Chronic Pulmonary Disease: A Retrospective Cohort Study

Author: Feng Q and Tong Z
Subjects: pneumocystis jirovecii, pneumonia, chronic pulmonary disease, prognostic factors, Infectious and parasitic diseases, RC109-216
Abstract: Qiuyue Feng,1,2 Zhaohui Tong1 1Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine, Beijing Chaoyang Hospital, Capital Medical University, Beijing, 100020, People’s Republic of China; 2Department of Respiratory and Critical Care Medicine, Beijing Huairou Hospital, Beijing, 101400, People’s Republic of ChinaCorrespondence: Zhaohui Tong, Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine, Beijing Chaoyang Hospital, Capital Medical University, NO. 8 Gong Ti South Road, Chaoyang District, Beijing, 100020, People’s Republic of China, Tel +86 13910930309, Email tongzhaohuicy@sina.comObjective: Pneumocystis jirovecii pneumonia (PJP) is a severe respiratory infection caused by Pneumocystis jirovecii in immunocompromised hosts. The role of P. jirovecii colonization in the development or progression of various pulmonary diseases has been reported. Our aim was to explore serial change in serum biomarkers and the independent risk factors for mortality in patients with and without chronic pulmonary diseases who developed PJP.Methods: We performed a retrospective study to select patients with Pneumocystis jirovecii pneumonia between January 1, 2012, and December 31, 2021. Information regarding demographics, clinical characteristics, underlying diseases, laboratory tests, treatment, and outcomes was collected. Univariate and multivariate logistic regression analyses were used to identify independent predictors of in-hospital mortality.Results: A total of 167 patients diagnosed with PJP were included in the study: 53 in the CPD-PJP group and 114 in the NCPD-PJP group. The number of patients with PJP showed an increasing trend over the 10-year period. A similar trend was observed for in-hospital mortality. Independent risk factors associated with death in the NCPD-PJP group were procalcitonin level (adjusted OR 1.08, 95% CI 1.01– 1.16, P=0.01), pneumothorax (adjusted OR 0.07, 95% CI 0.01– 0.38, P=0.002), neutrophil count (adjusted OR 1.27, 95% CI 1.05– 1.53, P=0.01) at 14 days, and hemoglobin level (adjusted OR 0.94, 95% CI 0.91– 0.98; P=0.002) at 14 days after admission. The risk factor associated with death in the CPD-PJP group was neutrophil count (adjusted OR 1.19, 95% CI 0.99– 1.43; P=0.05) at 14 days after admission.Conclusion: The risk factors for death were different between patients with PJP with and without chronic pulmonary disease. Early identification of these factors in patients with PJP and other underlying diseases may improve prognosis.Keywords: Pneumocystis jirovecii, pneumonia, chronic pulmonary disease, prognostic factors
Published: 2024

13. Background Determination for the LUX-ZEPLIN (LZ) Dark Matter Experiment

Author: Aalbers, J., Akerib, D. S., Musalhi, A. K. Al, Alder, F., Alsum, S. K., Amarasinghe, C. S., Ames, A., Anderson, T. J., Angelides, N., Araújo, H. M., Armstrong, J. E., Arthurs, M., Baker, A., Bang, J., Bargemann, J. W., Baxter, A., Beattie, K., Beltrame, P., Bernard, E. P., Bhatti, A., Biekert, A., Biesiadzinski, T. P., Birch, H. J., Blockinger, G. M., Boxer, B., Brew, C. A. J., Brás, P., Burdin, S., Buuck, M., Cabrita, R., Carmona-Benitez, M. C., Chan, C., Chawla, A., Chen, H., Chiang, A. P. S., Chott, N. I., Converse, M. V., Cottle, A., Cox, G., Creaner, O., Dahl, C. E., David, A., Dey, S., de Viveiros, L., Ding, C., Dobson, J. E. Y., Druszkiewicz, E., Eriksen, S. R., Fan, A., Fearon, N. M., Fiorucci, S., Flaecher, H., Fraser, E. D., Fruth, T., Gaitskell, R. J., Genovesi, J., Ghag, C., Gibbons, R., Gilchriese, M. G. D., Gokhale, S., Green, J., van der Grinten, M. G. D., Gwilliam, C. B., Hall, C. R., Han, S., Hartigan-O'Connor, E., Haselschwardt, S. J., Hertel, S. A., Heuermann, G., Horn, M., Huang, D. Q., Hunt, D., Ignarra, C. M., Jacobsen, R. G., Jahangir, O., James, R. S., Johnson, J., Kaboth, A. C., Kamaha, A. C., Khaitan, D., Khurana, I., Kirk, R., Kodroff, D., Korley, L., Korolkova, E. V., Kraus, H., Kravitz, S., Kreczko, L., Krikler, B., Kudryavtsev, V. A., Leason, E. A., Lee, J., Leonard, D. S., Lesko, K. T., Levy, C., Lin, J., Lindote, A., Linehan, R., Lippincott, W. H., Liu, X., Lopes, M. I., Asamar, E. Lopez, Paredes, B. López, Lorenzon, W., Lu, C., Luitz, S., Majewski, P. A., Manalaysay, A., Mannino, R. L., Marangou, N., McCarthy, M. E., McKinsey, D. N., McLaughlin, J., Miller, E. H., Mizrachi, E., Monte, A., Monzani, M. E., Mendoza, J. D. Morales, Morrison, E., Mount, B. J., Murdy, M., Murphy, A. St. J., Naim, D., Naylor, A., Nedlik, C., Nelson, H. N., Neves, F., Nguyen, A., Nikoleyczik, J. A., Olcina, I., Oliver-Mallory, K. C., Orpwood, J., Palladino, K. J., Palmer, J., Parveen, N., Patton, S. J., Penning, B., Pereira, G., Perry, E., Pershing, T., Piepke, A., Porzio, D., Poudel, S., Qie, Y., Reichenbacher, J., Rhyne, C. A., Riffard, Q., Rischbieter, G. R. C., Riyat, H. S., Rosero, R., Rossiter, P., Rushton, T., Santone, D., Sazzad, A. B. M. R., Schnee, R. W., Shaw, S., Shutt, T., Silk, J. J., Silva, C., Sinev, G., Smith, R., Solmaz, M., Solovov, V. N., Sorensen, P., Soria, J., Stancu, I., Stevens, A., Stifter, K., Suerfu, B., Sumner, T. J., Swanson, N., Szydagis, M., Taylor, R., Taylor, W. C., Temples, D. J., Terman, P. A., Tiedt, D. R., Timalsina, M., Tong, Z., Tovey, D. R., Tranter, J., Trask, M., Tripathi, M., Tronstad, D. R., Turner, W., Utku, U., Vaitkus, A. C., Wang, A., Wang, J. J., Wang, W., Wang, Y., Watson, J. R., Webb, R. C., Whitis, T. J., Williams, M., Wolfs, F. L. H., Woodford, S., Woodward, D., Wright, C. J., Xia, Q., Xiang, X., Xu, J., and Yeh, M.
Subjects: High Energy Physics - Experiment, Physics - Instrumentation and Detectors
Abstract: The LUX-ZEPLIN experiment recently reported limits on WIMP-nucleus interactions from its initial science run, down to $9.2\times10^{-48}$ cm$^2$ for the spin-independent interaction of a 36 GeV/c$^2$ WIMP at 90% confidence level. In this paper, we present a comprehensive analysis of the backgrounds important for this result and for other upcoming physics analyses, including neutrinoless double-beta decay searches and effective field theory interpretations of LUX-ZEPLIN data. We confirm that the in-situ determinations of bulk and fixed radioactive backgrounds are consistent with expectations from the ex-situ assays. The observed background rate after WIMP search criteria were applied was $(6.3\pm0.5)\times10^{-5}$ events/keV$_{ee}$/kg/day in the low-energy region, approximately 60 times lower than the equivalent rate reported by the LUX experiment., Comment: 25 pages, 15 figures
Published: 2022
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14. Nirmatrelvir–Ritonavir Reduced Mortality in Hospitalized Patients with COVID-19 During the Omicron Outbreak: Real-World Evidence from Beijing

Author: Zhang Y, Wang X, Huang C, Yang H, Jiang C, Yu X, Hong J, Wang Y, Zhao R, An Z, and Tong Z
Subjects: nirmatrelvir–ritonavir, covid-19, hospitalized., Infectious and parasitic diseases, RC109-216
Abstract: Yi Zhang,1,&ast; Xinrui Wang,1,&ast; Chong Huang,2 Hui Yang,1 Chunguo Jiang,3 Xiaojia Yu,1 Jun Hong,2 Yi Zhang,1 Yushu Wang,1 Rui Zhao,1 Zhuoling An,1 Zhaohui Tong3 1Department of Pharmacy, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, People’s Republic of China; 2School of Pharmaceutical Sciences, Capital Medical University, Beijing, People’s Republic of China; 3Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Zhuoling An, Department of Pharmacy, Beijing Chao-Yang Hospital, Capital Medical University, 8 Gongren Tiyuchang Nanlu, Chaoyang District, Beijing, 100020, People’s Republic of China, Tel +00-86-010-85231362, Email anzhuoling@163.com Zhaohui Tong, Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine, Beijing Chao-Yang Hospital, Capital Medical University, 8 Gongren Tiyuchang Nanlu, Chaoyang District, Beijing, 100020, People’s Republic of China, Tel +00-86-010-85231464, Email tongzhaohuicy@sina.comObjective: The efficacy of nirmatrelvir–ritonavir for hospitalized patients with COVID-19 has not been fully established.Methods: We conducted a retrospective analysis of hospitalized COVID– 19 patients with high risk for disease progression at Beijing Chaoyang Hospital from October 15, 2022, to March 31, 2023. Patients ≥ 18 years old who were hospitalized with COVID-19 within 5 days of symptom onset were included. Baseline data were obtained from the routine electronic health record database of the hospital information system. Outcomes were monitored at 28 days via electronic medical record reviews or telephone interviews.Results: We identified 1120 patients hospitalized with COVID-19 during the study period. After exclusions, 167 nirmatrelvir–ritonavir users and 132 controls were included. 28-day all-cause mortality rate was 12.0% (20/167) in the nirmatrelvir–ritonavir group, versus 22.7% (30/132) in the control group (unadjusted log-rank p = 0.010; HR = 0.49, 95% confidence interval [CI] = 0.28– 0.86, IPTW-adjusted HR = 0.58, 95% CI = 0.40– 0.86). The 28-day disease progression rates did not differ between the two groups (unadjusted HR = 0.59, 95% CI = 0.34– 1.02, IPTW-adjusted HR = 0.73, 95% CI = 0.50– 1.06). Nirmatrelvir–ritonavir significantly reduced all-cause mortality and disease progression within 28 days among patients aged ≥ 65 years without ≥ 2 vaccine doses.Conclusion: We found significantly reduced all-cause mortality in the nirmatrelvir–ritonavir group, particularly in elderly patients who were incompletely vaccinated. Future randomized controlled studies are needed to validate our findings.Keywords: nirmatrelvir–ritonavir, COVID-19, hospitalized
Published: 2024

15. Serum HER2 Level Predicts Therapeutic Efficacy and Prognosis in Advanced Breast Cancer Patients

Author: Wang S, Chen Y, Li W, Hao C, Zhang L, Zhao W, Shi Y, and Tong Z
Subjects: serum her2, advanced breast cancer, clinicopathological characteristics；therapeutic efficacy, prognosis, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract: Shuling Wang,1,2,&ast; Yuqin Chen,1– 3,&ast; Weidong Li,2,4,&ast; Chunfang Hao,1,2 Li Zhang,1,2 Weipeng Zhao,1,2 Yehui Shi,1,2 Zhongsheng Tong1,2 1Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, People’s Republic of China; 2Tianjin’s Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin, People’s Republic of China; 3Department of Respiratory Center, The Second Affiliated Hospital of Xiamen Medical College, Xiamen, People’s Republic of China; 4Department of Breast Cancer Pathology and Research Laboratory, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Yehui Shi; Zhongsheng Tong, Email shiyehui@tjmuch.com; tongzhongsheng_on@163.comBackground: The purpose of this study was to investigate the therapeutic efficacy and prognosis of serum HER2 (sHER2) in patients with advanced breast cancer.Methods: We analyzed the sHER2 levels of 200 patients with advanced breast cancer receiving first or second line treatment, the tissue HER2 (tHER2) level was also analyzed. Indicators of therapeutic efficacy and prognosis were objective response rate (ORR), disease control rate (DCR), and time to progression (TTP).Results: The baseline sHER2 level was high in 132 patients and low in 68 patients. The high level of sHER2 is correlated with molecular subtype (p=0.016), visceral metastasis (p< 0.001), liver metastasis (p< 0.001), tissue HER-2 (tHER2) (p=0.001), and, among tHER2-low tumors (59 patients), the baseline sHER2 high level was associated with a higher proportion of brain metastasis. The ORR of patients with baseline sHER2 high level is higher than those with baseline sHER2 low level (p=0.026). The TTP of patients with baseline sHER2 low level is longer than the patients with baseline sHER2 high level (p=0.024). For patients with baseline sHER2 high level, a significant decrease in sHER2 after two cycles of treatment indicates higher ORR, DCR, and an extension of TTP. After multiple cycles of treatment, for patients with tHER-2 positive and baseline sHER2 high level, the DCR in the sHER2 decrease in the negative group was higher than that in the continuous positive group (p=0.037). Patients with a rapid decline type of sHER2 dynamic change curve had higher ORR and prolonged TTP compared with patients with other types of sHER2 dynamic change curve. There is no correlation between OS and sHER2 levels.Conclusion: Our study showed that patients with advanced breast cancer had a high level of sHER2 at recurrence, regardless of whether they are tHER2 positive or negative. Dynamic detection of sHER2 can help predict therapeutic efficacy and prognosis, regardless of whether tHER-2 is positive or negative.Keywords: serum HER2, advanced breast cancer, clinicopathological characteristics, therapeutic efficacy, prognosis
Published: 2024

16. Comprehensive Nomograms Using Routine Biomarkers Beyond Eosinophil Levels: Enhancing Predictability of Corticosteroid Treatment Outcomes in AECOPD

Author: Feng L, Li J, Qian Z, Li C, Gao D, Wang Y, Xie W, Cai Y, Tong Z, and Liang L
Subjects: chronic obstructive pulmonary disease, glucocorticoids, prediction model, least absolute shrinkage and selection operator, Pathology, RB1-214, Therapeutics. Pharmacology, RM1-950
Abstract: Lin Feng,1 Jiachen Li,1 Zhenbei Qian,2 Chenglong Li,3,4 Darui Gao,3,4 Yongqian Wang,3,4 Wuxiang Xie,3,4 Yutong Cai,5 Zhaohui Tong,2 Lirong Liang1 1Department of Clinical Epidemiology, Beijing Institute of Respiratory Medicine and Beijing Chao-Yang Hospital, Capital Medical University, Beijing, People’s Republic of China; 2Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-Yang Hospital, Capital Medical University, Beijing, People’s Republic of China; 3Heart and Vascular Health Research Center, Peking University Clinical Research Institute, Peking University First Hospital, Beijing, People’s Republic of China; 4Key Laboratory of Epidemiology of Major Diseases (Peking University), Ministry of Education, Beijing, People’s Republic of China; 5Centre for Environmental Health and Sustainability, Department of Health Sciences, University of Leicester, Leicester, UKCorrespondence: Lirong Liang, Department of Clinical Epidemiology, Beijing Institute of Respiratory Medicine and Beijing Chao-Yang Hospital, Capital Medical University, Beijing, People’s Republic of China, Email llrcruie@163.comPurpose: Patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) exhibit heterogeneous responses to corticosteroid treatment. We aimed to determine whether combining eosinophil levels with other routine clinical indicators can enhance the predictability of corticosteroid treatment outcomes and to come up with a scoring system.Patients and Methods: Consecutive patients admitted with AECOPD receiving corticosteroid treatment between July 2013 and March 2022 at Beijing Chao-Yang Hospital were retrospectively analyzed. Data on patients’ demographics, smoking status, hospitalization for AECOPD in the previous year, comorbidities, blood laboratory tests, in-hospital treatment and clinical outcomes were collected. Least absolute shrinkage and selection operator (LASSO) regression and backward logistic regression were used for predictor selection, and predictive nomograms were developed. The discrimination and calibration of the nomograms were assessed using the area under the receiver operating curve (AUC) and calibration plots. Internal validation was performed using the 500-bootstrap method, and clinical utility was evaluated using decision curve analysis (DCA).Results: Among the 3254 patients included, 804 (24.7%) had treatment failure. A nomogram of eosinophils, platelets, C-reactive protein (CRP), low density lipoprotein cholesterol, prognostic nutritional index (PNI), hospitalization for AECOPD in the previous year, ischemic heart diseases and chronic hepatic disease was developed to predict treatment failure for patients with a smoking history. For patients without a smoking history, a nomogram of CRP, PNI, ischemic heart diseases and chronic hepatic disease was developed. Although the AUCs of these two nomograms were only 0.644 and 0.647 respectively, they were significantly superior to predictions based solely on blood eosinophil levels.Conclusion: We developed easy-to-use comprehensive nomograms utilizing readily available clinical biomarkers related to inflammation, nutrition and immunity, offering modestly enhanced predictive value for treatment outcomes in corticosteroid-treated patients with AECOPD. Further investigations into novel biomarkers and additional patient data are imperative to optimize the predictive performance.Keywords: chronic obstructive pulmonary disease, glucocorticoids, prediction model, least absolute shrinkage and selection operator
Published: 2024

17. Genomic Sequencing of Clinical Cupriavidus gilardii Isolates Revealed Their Diverse Antimicrobial Resistance Mechanisms

Author: Zhao W, Yang H, Huang Y, Fan X, and Tong Z
Subjects: cupriavidus gilardii, clinical characteristics, antimicrobial resistance, mcr-5.1, gyra., Infectious and parasitic diseases, RC109-216
Abstract: Weichao Zhao,1,2,&ast; Huqin Yang,1,&ast; Yong Huang,3,&ast; Xin Fan,4 Zhaohui Tong1 1Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, People’s Republic of China; 2Department of Respiratory Medicine, Strategic Support Force Medical Center, Beijing, People’s Republic of China; 3State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, People’s Republic of China; 4Department of Infectious Diseases and Clinical Microbiology, Beijing Institute of Respiratory Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Zhaohui Tong; Xin Fan, NO. 8 Gong Ti South Road, Beijing, 10020, People’s Republic of China, Tel +86 1085231297 ; +86 13521438062, Email tongzhaohuicy@sina.com; fanxin123356@163.comPurpose: Cupriavidus gilardii is an emerging multidrug-resistant pathogen found in many environments and few clinical samples. The clinical infectiousness, pathogenicity, and resistance mechanisms of C. gilardii are still unclear due to the lack of clinical and sequencing data. We need to obtain insight into the clinical characteristics, virulence, and resistance mechanisms of C. gilardii.Patients and Methods: We isolated five C. gilardii isolates from hospitalized patients and carried out assay, culture and genome sequencing. We analyzed the genomic features of clinical C. gilardii isolates and took insight into their clinical characteristics, virulence, and resistance mechanisms.Results: These isolates were resistant to meropenem, gentamicin, and other antimicrobials due to intrinsic resistance genes. Furthermore, the sequencing results revealed the widespread presence of the MCR-5.1 gene in C. gilardii. The virulence magnitude of C. gilardii is closely correlated with the number of virulence factors they carry. Some C. gilardii strains can acquire resistance to levofloxacin through gyrA gene mutation during treatment. The diverse antimicrobial resistance mechanisms challenge the treatment of C. gilardii infections.Conclusion: We present the genomic characteristics of clinically isolated C. gilardii to improve (i) our understanding of this pathogen and (ii) treatment options.Keywords: Cupriavidus gilardii, clinical characteristics, antimicrobial resistance, MCR-5.1, gyrA
Published: 2024

18. Suppurative Meningitis Complicated with Arthritis Caused by Streptococcus Suis Infection: A Case Report

Author: Shen B, Tong L, Qiu J, Zhong J, Tong Z, and Li X
Subjects: arthritis, hearing loss, hyperbaric oxygen therapy, meningitis, streptococcus suis, Infectious and parasitic diseases, RC109-216
Abstract: Bin Shen, Luyuan Tong, Jia Qiu, Jianfeng Zhong, Zhaowei Tong, Xiaofeng Li Department of Infectious Diseases, Huzhou Central Hospital, Huzhou Key Laboratory of Precision Medicine Research and Translation for Infectious Diseases, Huzhou, Zhejiang Province, 313000, People’s Republic of ChinaCorrespondence: Xiaofeng Li, Department of Infectious Diseases, Huzhou Central Hospital.Huzhou Key Laboratory of Precision Medicine Research and Translation for Infectious Diseases, No. 1558, Sanhuan North Road Wuxing District, Huzhou, Zhejiang Province, 313000, People’s Republic of China, Email xf_li0728@163.comBackground: Streptococcus suis (S. suis) is a common gram-positive bacterium in pigs. Its natural infection sites are the upper respiratory tract (especially tonsils and nasal cavity), reproductive tract and digestive tract of pigs. It is a new emerging human and animal disease. A co-morbid pathogen that can cause serious infections in humans, including meningitis, sepsis, septic arthritis, and sometimes deafness. No cases have been reported in Huzhou City, Zhejiang Province, China.Case Presentation: A 50-year-old male patient who had Worked as a butcher in a slaughterhouse for 20 years. Admitted to the hospital due to abdominal pain, joint pain, fever, and headache.His condition rapidly worsened causing altered consciousness, drowsiness and developed hearing loss. S. suis induced pyogenic meningitis complicated by arthritis was suspected based on the results of biochemical and culture analysis of the cerebrospinal fluid, and metagenomic next-generation sequencing, The patient’s symptoms significantly improved after treatment with antibiotics such as ceftriaxone, meropenem, and linezolid, as well as supportive therapies including steroids and hyperbaric oxygen therapy, and his hearing improved significantly.After about 2 years of follow-up, the hearing was significantly better than before, but hearing impairment still remained.Conclusion: Streptococcus suis is endemic in pork-consuming and pig-raising countries, but can occur throughout the world, especially among individuals with occupational exposure to pigs and/or pork, such as slaughterhouse workers, butchers, farmers, etc. Strengthen science education among key groups. This case was diagnosed as Streptococcus suis meningitis combined with arthritis. However, abdominal pain in the early stage of the disease is very rare and is easy to be misdiagnosed. It is necessary to identify whether it is complicated by peritonitis. For hearing loss caused by Streptococcus suis infection, the use of hyperbaric oxygen chamber treatment has obvious therapeutic effects.Keywords: arthritis, hearing loss, hyperbaric oxygen therapy, meningitis, streptococcus suis
Published: 2024

19. First Dark Matter Search Results from the LUX-ZEPLIN (LZ) Experiment

Author: Aalbers, J., Akerib, D. S., Akerlof, C. W., Musalhi, A. K. Al, Alder, F., Alqahtani, A., Alsum, S. K., Amarasinghe, C. S., Ames, A., Anderson, T. J., Angelides, N., Araújo, H. M., Armstrong, J. E., Arthurs, M., Azadi, S., Bailey, A. J., Baker, A., Balajthy, J., Balashov, S., Bang, J., Bargemann, J. W., Barry, M. J., Barthel, J., Bauer, D., Baxter, A., Beattie, K., Belle, J., Beltrame, P., Bensinger, J., Benson, T., Bernard, E. P., Bhatti, A., Biekert, A., Biesiadzinski, T. P., Birch, H. J., Birrittella, B., Blockinger, G. M., Boast, K. E., Boxer, B., Bramante, R., Brew, C. A. J., Brás, P., Buckley, J. H., Bugaev, V. V., Burdin, S., Busenitz, J. K., Buuck, M., Cabrita, R., Carels, C., Carlsmith, D. L., Carlson, B., Carmona-Benitez, M. C., Cascella, M., Chan, C., Chawla, A., Chen, H., Cherwinka, J. J., Chott, N. I., Cole, A., Coleman, J., Converse, M. V., Cottle, A., Cox, G., Craddock, W. W., Creaner, O., Curran, D., Currie, A., Cutter, J. E., Dahl, C. E., David, A., Davis, J., Davison, T. J. R., Delgaudio, J., Dey, S., de Viveiros, L., Dobi, A., Dobson, J. E. Y., Druszkiewicz, E., Dushkin, A., Edberg, T. K., Edwards, W. R., Elnimr, M. M., Emmet, W. T., Eriksen, S. R., Faham, C. H., Fan, A., Fayer, S., Fearon, N. M., Fiorucci, S., Flaecher, H., Ford, P., Francis, V. B., Fraser, E. D., Fruth, T., Gaitskell, R. J., Gantos, N. J., Garcia, D., Geffre, A., Gehman, V. M., Genovesi, J., Ghag, C., Gibbons, R., Gibson, E., Gilchriese, M. G. D., Gokhale, S., Gomber, B., Green, J., Greenall, A., Greenwood, S., van der Grinten, M. G. D., Gwilliam, C. B., Hall, C. R., Hans, S., Hanzel, K., Harrison, A., Hartigan-O'Connor, E., Haselschwardt, S. J., Hertel, S. A., Heuermann, G., Hjemfelt, C., Hoff, M. D., Holtom, E., Hor, J. Y-K., Horn, M., Huang, D. Q., Hunt, D., Ignarra, C. M., Jacobsen, R. G., Jahangir, O., James, R. S., Jeffery, S. N., Ji, W., Johnson, J., Kaboth, A. C., Kamaha, A. C., Kamdin, K., Kasey, V., Kazkaz, K., Keefner, J., Khaitan, D., Khaleeq, M., Khazov, A., Khurana, I., Kim, Y. D., Kocher, C. D., Kodroff, D., Korley, L., Korolkova, E. V., Kras, J., Kraus, H., Kravitz, S., Krebs, H. J., Kreczko, L., Krikler, B., Kudryavtsev, V. A., Kyre, S., Landerud, B., Leason, E. A., Lee, C., Lee, J., Leonard, D. S., Leonard, R., Lesko, K. T., Levy, C., Li, J., Liao, F. -T., Liao, J., Lin, J., Lindote, A., Linehan, R., Lippincott, W. H., Liu, R., Liu, X., Liu, Y., Loniewski, C., Lopes, M. I., Asamar, E. Lopez, Paredes, B. López, Lorenzon, W., Lucero, D., Luitz, S., Lyle, J. M., Majewski, P. A., Makkinje, J., Malling, D. C., Manalaysay, A., Manenti, L., Mannino, R. L., Marangou, N., Marzioni, M. F., Maupin, C., McCarthy, M. E., McConnell, C. T., McKinsey, D. N., McLaughlin, J., Meng, Y., Migneault, J., Miller, E. H., Mizrachi, E., Mock, J. A., Monte, A., Monzani, M. E., Morad, J. A., Mendoza, J. D. Morales, Morrison, E., Mount, B. J., Murdy, M., Murphy, A. St. J., Naim, D., Naylor, A., Nedlik, C., Nehrkorn, C., Neves, F., Nguyen, A., Nikoleyczik, J. A., Nilima, A., O'Dell, J., O'Neill, F. G., O'Sullivan, K., Olcina, I., Olevitch, M. A., Oliver-Mallory, K. C., Orpwood, J., Pagenkopf, D., Pal, S., Palladino, K. J., Palmer, J., Pangilinan, M., Parveen, N., Patton, S. J., Pease, E. K., Penning, B., Pereira, C., Pereira, G., Perry, E., Pershing, T., Peterson, I. B., Piepke, A., Podczerwinski, J., Porzio, D., Powell, S., Preece, R. M., Pushkin, K., Qie, Y., Ratcliff, B. N., Reichenbacher, J., Reichhart, L., Rhyne, C. A., Richards, A., Riffard, Q., Rischbieter, G. R. C., Rodrigues, J. P., Rodriguez, A., Rose, H. J., Rosero, R., Rossiter, P., Rushton, T., Rutherford, G., Rynders, D., Saba, J. S., Santone, D., Sazzad, A. B. M. R., Schnee, R. W., Scovell, P. R., Seymour, D., Shaw, S., Shutt, T., Silk, J. J., Silva, C., Sinev, G., Skarpaas, K., Skulski, W., Smith, R., Solmaz, M., Solovov, V. N., Sorensen, P., Soria, J., Stancu, I., Stark, M. R., Stevens, A., Stiegler, T. M., Stifter, K., Studley, R., Suerfu, B., Sumner, T. J., Sutcliffe, P., Swanson, N., Szydagis, M., Tan, M., Taylor, D. J., Taylor, R., Taylor, W. C., Temples, D. J., Tennyson, B. P., Terman, P. A., Thomas, K. J., Tiedt, D. R., Timalsina, M., To, W. H., Tomás, A., Tong, Z., Tovey, D. R., Tranter, J., Trask, M., Tripathi, M., Tronstad, D. R., Tull, C. E., Turner, W., Tvrznikova, L., Utku, U., Va'vra, J., Vacheret, A., Vaitkus, A. C., Verbus, J. R., Voirin, E., Waldron, W. L., Wang, A., Wang, B., Wang, J. J., Wang, W., Wang, Y., Watson, J. R., Webb, R. C., White, A., White, D. T., White, J. T., White, R. G., Whitis, T. J., Williams, M., Wisniewski, W. J., Witherell, M. S., Wolfs, F. L. H., Wolfs, J. D., Woodford, S., Woodward, D., Worm, S. D., Wright, C. J., Xia, Q., Xiang, X., Xiao, Q., Xu, J., Yeh, M., Yin, J., Young, I., Zarzhitsky, P., Zuckerman, A., and Zweig, E. A.
Subjects: High Energy Physics - Experiment, Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract: The LUX-ZEPLIN experiment is a dark matter detector centered on a dual-phase xenon time projection chamber operating at the Sanford Underground Research Facility in Lead, South Dakota, USA. This Letter reports results from LUX-ZEPLIN's first search for weakly interacting massive particles (WIMPs) with an exposure of 60~live days using a fiducial mass of 5.5 t. A profile-likelihood ratio analysis shows the data to be consistent with a background-only hypothesis, setting new limits on spin-independent WIMP-nucleon, spin-dependent WIMP-neutron, and spin-dependent WIMP-proton cross sections for WIMP masses above 9 GeV/c$^2$. The most stringent limit is set for spin-independent scattering at 36 GeV/c$^2$, rejecting cross sections above 9.2$\times 10^{-48}$ cm$^2$ at the 90% confidence level., Comment: 9 pages, 8 figures. See https://doi.org/10.1103/PhysRevLett.131.041002 for a data release related to this paper
Published: 2022
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20. Interference analysis of heterogeneous materials on ground-penetrating radar target echoes

Author: Ma, T., primary, Zhang, Y.M., additional, Zhang, W.G., additional, and Tong, Z., additional
Published: 2023
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21. A Next-Generation Liquid Xenon Observatory for Dark Matter and Neutrino Physics

Author: Aalbers, J., Abe, K., Aerne, V., Agostini, F., Maouloud, S. Ahmed, Akerib, D. S., Akimov, D. Yu., Akshat, J., Musalhi, A. K. Al, Alder, F., Alsum, S. K., Althueser, L., Amarasinghe, C. S., Amaro, F. D., Ames, A., Anderson, T. J., Andrieu, B., Angelides, N., Angelino, E., Angevaare, J., Antochi, V. C., Martin, D. Antón, Antunovic, B., Aprile, E., Araújo, H. M., Armstrong, J. E., Arneodo, F., Arthurs, M., Asadi, P., Baek, S., Bai, X., Bajpai, D., Baker, A., Balajthy, J., Balashov, S., Balzer, M., Bandyopadhyay, A., Bang, J., Barberio, E., Bargemann, J. W., Baudis, L., Bauer, D., Baur, D., Baxter, A., Baxter, A. L., Bazyk, M., Beattie, K., Behrens, J., Bell, N. F., Bellagamba, L., Beltrame, P., Benabderrahmane, M., Bernard, E. P., Bertone, G. F., Bhattacharjee, P., Bhatti, A., Biekert, A., Biesiadzinski, T. P., Binau, A. R., Biondi, R., Biondi, Y., Birch, H. J., Bishara, F., Bismark, A., Blanco, C., Blockinger, G. M., Bodnia, E., Boehm, C., Bolozdynya, A. I., Bolton, P. D., Bottaro, S., Bourgeois, C., Boxer, B., Brás, P., Breskin, A., Breur, P. A., Brew, C. A. J., Brod, J., Brookes, E., Brown, A., Brown, E., Bruenner, S., Bruno, G., Budnik, R., Bui, T. K., Burdin, S., Buse, S., Busenitz, J. K., Buttazzo, D., Buuck, M., Buzulutskov, A., Cabrita, R., Cai, C., Cai, D., Capelli, C., Cardoso, J. M. R., Carmona-Benitez, M. C., Cascella, M., Catena, R., Chakraborty, S., Chan, C., Chang, S., Chauvin, A., Chawla, A., Chen, H., Chepel, V., Chott, N. I., Cichon, D., Chavez, A. Cimental, Cimmino, B., Clark, M., Co, R. T., Colijn, A. P., Conrad, J., Converse, M. V., Costa, M., Cottle, A., Cox, G., Creaner, O., Garcia, J. J. Cuenca, Cussonneau, J. P., Cutter, J. E., Dahl, C. E., D'Andrea, V., David, A., Decowski, M. P., Dent, J. B., Deppisch, F. F., de Viveiros, L., Di Gangi, P., Di Giovanni, A., Di Pede, S., Dierle, J., Diglio, S., Dobson, J. E. Y., Doerenkamp, M., Douillet, D., Drexlin, G., Druszkiewicz, E., Dunsky, D., Eitel, K., Elykov, A., Emken, T., Engel, R., Eriksen, S. R., Fairbairn, M., Fan, A., Fan, J. J., Farrell, S. J., Fayer, S., Fearon, N. M., Ferella, A., Ferrari, C., Fieguth, A., Fiorucci, S., Fischer, H., Flaecher, H., Flierman, M., Florek, T., Foot, R., Fox, P. J., Franceschini, R., Fraser, E. D., Frenk, C. S., Frohlich, S., Fruth, T., Fulgione, W., Fuselli, C., Gaemers, P., Gaior, R., Gaitskell, R. J., Galloway, M., Gao, F., Garcia, I. Garcia, Genovesi, J., Ghag, C., Ghosh, S., Gibson, E., Gil, W., Giovagnoli, D., Girard, F., Glade-Beucke, R., Glück, F., Gokhale, S., de Gouvêa, A., Gráf, L., Grandi, L., Grigat, J., Grinstein, B., van der Grinten, M. G. D., Grössle, R., Guan, H., Guida, M., Gumbsheimer, R., Gwilliam, C. B., Hall, C. R., Hall, L. J., Hammann, R., Han, K., Hannen, V., Hansmann-Menzemer, S., Harata, R., Hardin, S. P., Hardy, E., Hardy, C. A., Harigaya, K., Harnik, R., Haselschwardt, S. J., Hernandez, M., Hertel, S. A., Higuera, A., Hils, C., Hochrein, S., Hoetzsch, L., Hoferichter, M., Hood, N., Hooper, D., Horn, M., Howlett, J., Huang, D. Q., Huang, Y., Hunt, D., Iacovacci, M., Iaquaniello, G., Ide, R., Ignarra, C. M., Iloglu, G., Itow, Y., Jacquet, E., Jahangir, O., Jakob, J., James, R. S., Jansen, A., Ji, W., Ji, X., Joerg, F., Johnson, J., Joy, A., Kaboth, A. C., Kamaha, A. C., Kanezaki, K., Kar, K., Kara, M., Kato, N., Kavrigin, P., Kazama, S., Keaveney, A. W., Kellerer, J., Khaitan, D., Khazov, A., Khundzakishvili, G., Khurana, I., Kilminster, B., Kleifges, M., Ko, P., Kobayashi, M., Kodroff, D., Koltmann, G., Kopec, A., Kopmann, A., Kopp, J., Korley, L., Kornoukhov, V. N., Korolkova, E. V., Kraus, H., Krauss, L. M., Kravitz, S., Kreczko, L., Kudryavtsev, V. A., Kuger, F., Kumar, J., Paredes, B. López, LaCascio, L., Laine, Q., Landsman, H., Lang, R. F., Leason, E. A., Lee, J., Leonard, D. S., Lesko, K. T., Levinson, L., Levy, C., Li, I., Li, S. C., Li, T., Liang, S., Liebenthal, C. S., Lin, J., Lin, Q., Lindemann, S., Lindner, M., Lindote, A., Linehan, R., Lippincott, W. H., Liu, X., Liu, K., Liu, J., Loizeau, J., Lombardi, F., Long, J., Lopes, M. I., Asamar, E. Lopez, Lorenzon, W., Lu, C., Luitz, S., Ma, Y., Machado, P. A. N., Macolino, C., Maeda, T., Mahlstedt, J., Majewski, P. A., Manalaysay, A., Mancuso, A., Manenti, L., Manfredini, A., Mannino, R. L., Marangou, N., March-Russell, J., Marignetti, F., Undagoitia, T. Marrodán, Martens, K., Martin, R., Martinez-Soler, I., Masbou, J., Masson, D., Masson, E., Mastroianni, S., Mastronardi, M., Matias-Lopes, J. A., McCarthy, M. E., McFadden, N., McGinness, E., McKinsey, D. N., McLaughlin, J., McMichael, K., Meinhardt, P., Menéndez, J., Meng, Y., Messina, M., Midha, R., Milisavljevic, D., Miller, E. H., Milosevic, B., Milutinovic, S., Mitra, S. A., Miuchi, K., Mizrachi, E., Mizukoshi, K., Molinario, A., Monte, A., Monteiro, C. M. B., Monzani, M. E., Moore, J. S., Morå, K., Morad, J. A., Mendoza, J. D. Morales, Moriyama, S., Morrison, E., Morteau, E., Mosbacher, Y., Mount, B. J., Mueller, J., Murphy, A. St. J., Murra, M., Naim, D., Nakamura, S., Nash, E., Navaieelavasani, N., Naylor, A., Nedlik, C., Nelson, H. N., Neves, F., Newstead, J. L., Ni, K., Nikoleyczik, J. A., Niro, V., Oberlack, U. G., Obradovic, M., Odgers, K., O'Hare, C. A. J., Oikonomou, P., Olcina, I., Oliver-Mallory, K., Oranday, A., Orpwood, J., Ostrovskiy, I., Ozaki, K., Paetsch, B., Pal, S., Palacio, J., Palladino, K. J., Palmer, J., Panci, P., Pandurovic, M., Parlati, A., Parveen, N., Patton, S. J., Pěč, V., Pellegrini, Q., Penning, B., Pereira, G., Peres, R., Perez-Gonzalez, Y., Perry, E., Pershing, T., Petrossian-Byrne, R., Pienaar, J., Piepke, A., Pieramico, G., Pierre, M., Piotter, M., Pizella, V., Plante, G., Pollmann, T., Porzio, D., Qi, J., Qie, Y., Qin, J., Raj, N., Silva, M. Rajado, Ramanathan, K., García, D. Ramírez, Ravanis, J., Redard-Jacot, L., Redigolo, D., Reichard, S., Reichenbacher, J., Rhyne, C. A., Richards, A., Riffard, Q., Rischbieter, G. R. C., Rocchetti, A., Rosenfeld, S. L., Rosero, R., Rupp, N., Rushton, T., Saha, S., Sanchez, L., Sanchez-Lucas, P., Santone, D., Santos, J. M. F. dos, Sarnoff, I., Sartorelli, G., Sazzad, A. B. M. R., Scheibelhut, M., Schnee, R. W., Schrank, M., Schreiner, J., Schulte, P., Schulte, D., Eissing, H. Schulze, Schumann, M., Schwemberger, T., Schwenk, A., Schwetz, T., Lavina, L. Scotto, Scovell, P. R., Sekiya, H., Selvi, M., Semenov, E., Semeria, F., Shagin, P., Shaw, S., Shi, S., Shockley, E., Shutt, T. A., Si-Ahmed, R., Silk, J. J., Silva, C., Silva, M. C., Simgen, H., Šimkovic, F., Sinev, G., Singh, R., Skulski, W., Smirnov, J., Smith, R., Solmaz, M., Solovov, V. N., Sorensen, P., Soria, J., Sparmann, T. J., Stancu, I., Steidl, M., Stevens, A., Stifter, K., Strigari, L. E., Subotic, D., Suerfu, B., Suliga, A. M., Sumner, T. J., Szabo, P., Szydagis, M., Takeda, A., Takeuchi, Y., Tan, P. -L., Taricco, C., Taylor, W. C., Temples, D. J., Terliuk, A., Terman, P. A., Thers, D., Thieme, K., Thümmler, Th., Tiedt, D. R., Timalsina, M., To, W. H., Toennies, F., Tong, Z., Toschi, F., Tovey, D. R., Tranter, J., Trask, M., Trinchero, G. C., Tripathi, M., Tronstad, D. R., Trotta, R., Tsai, Y. D., Tunnell, C. D., Turner, W. G., Ueno, R., Urquijo, P., Utku, U., Vaitkus, A., Valerius, K., Vassilev, E., Vecchi, S., Velan, V., Vetter, S., Vincent, A. C., Vittorio, L., Volta, G., von Krosigk, B., von Piechowski, M., Vorkapic, D., Wagner, C. E. M., Wang, A. M., Wang, B., Wang, Y., Wang, W., Wang, J. J., Wang, L. -T., Wang, M., Watson, J. R., Wei, Y., Weinheimer, C., Weisman, E., Weiss, M., Wenz, D., West, S. M., Whitis, T. J., Williams, M., Wilson, M. J., Winkler, D., Wittweg, C., Wolf, J., Wolf, T., Wolfs, F. L. H., Woodford, S., Woodward, D., Wright, C. J., Wu, V. H. S., Wu, P., Wüstling, S., Wurm, M., Xia, Q., Xiang, X., Xing, Y., Xu, J., Xu, Z., Xu, D., Yamashita, M., Yamazaki, R., Yan, H., Yang, L., Yang, Y., Ye, J., Yeh, M., Young, I., Yu, H. B., Yu, T. T., Yuan, L., Zavattini, G., Zerbo, S., Zhang, Y., Zhong, M., Zhou, N., Zhou, X., Zhu, T., Zhu, Y., Zhuang, Y., Zopounidis, J. P., Zuber, K., and Zupan, J.
Subjects: Physics - Instrumentation and Detectors, Astrophysics - Cosmology and Nongalactic Astrophysics, High Energy Physics - Experiment, Nuclear Experiment
Abstract: The nature of dark matter and properties of neutrinos are among the most pressing issues in contemporary particle physics. The dual-phase xenon time-projection chamber is the leading technology to cover the available parameter space for Weakly Interacting Massive Particles (WIMPs), while featuring extensive sensitivity to many alternative dark matter candidates. These detectors can also study neutrinos through neutrinoless double-beta decay and through a variety of astrophysical sources. A next-generation xenon-based detector will therefore be a true multi-purpose observatory to significantly advance particle physics, nuclear physics, astrophysics, solar physics, and cosmology. This review article presents the science cases for such a detector., Comment: 77 pages, 40 figures, 1262 references
Published: 2022
Full Text: View/download PDF

22. Cosmogenic production of $^{37}$Ar in the context of the LUX-ZEPLIN experiment

Author: Aalbers, J., Akerib, D. S., Musalhi, A. K. Al, Alder, F., Alsum, S. K., Amarasinghe, C. S., Ames, A., Anderson, T. J., Angelides, N., Araújo, H. M., Armstrong, J. E., Arthurs, M., Bai, X., Baker, A., Balajthy, J., Balashov, S., Bang, J., Bargemann, J. W., Bauer, D., Baxter, A., Beattie, K., Bernard, E. P., Bhatti, A., Biekert, A., Biesiadzinski, T. P., Birch, H. J., Blockinger, G. M., Bodnia, E., Boxer, B., Brew, C. A. J., Brás, P., Burdin, S., Busenitz, J. K., Buuck, M., Cabrita, R., Carmona-Benitez, M. C., Cascella, M., Chan, C., Chawla, A., Chen, H., Chott, N. I., Cole, A., Converse, M. V., Cottle, A., Cox, G., Creaner, O., Cutter, J. E., Dahl, C. E., David, A., de Viveiros, L., Dobson, J. E. Y., Druszkiewicz, E., Eriksen, S. R., Fan, A., Fayer, S., Fearon, N. M., Fiorucci, S., Flaecher, H., Fraser, E. D., Fruth, T., Gaitskell, R. J., Genovesi, J., Ghag, C., Gibson, E., Gilchriese, M. G. D., Gokhale, S., van der Grinten, M. G. D., Gwilliam, C. B., Hall, C. R., Haselschwardt, S. J., Hertel, S. A., Horn, M., Huang, D. Q., Hunt, D., Ignarra, C. M., Jahangir, O., James, R. S., Ji, W., Johnson, J., Kaboth, A. C., Kamaha, A. C., Kamdin, K., Khaitan, D., Khazov, A., Khurana, I., Kodroff, D., Korley, L., Korolkova, E. V., Kraus, H., Kravitz, S., Kreczko, L., Kudryavtsev, V. A., Leason, E. A., Leonard, D. S., Lesko, K. T., Levy, C., Lee, J., Lin, J., Lindote, A., Linehan, R., Lippincott, W. H., Liu, X., Lopes, M. I., Asamar, E. Lopez, Lopez-Paredes, B., Lorenzon, W., Luitz, S., Majewski, P. A., Manalaysay, A., Manenti, L., Mannino, R. L., Marangou, N., McCarthy, M. E., McKinsey, D. N., McLaughlin, J., Miller, E. H., Mizrachi, E., Monte, A., Monzani, M. E., Morad, J. A., Mendoza, J. D. Morales, Morrison, E., Mount, B. J., Murphy, A. St. J., Naim, D., Naylor, A., Nedlik, C., Nelson, H. N., Neves, F., Nikoleyczik, J. A., Nilima, A., Olcina, I., Oliver-Mallory, K., Pal, S., Palladino, K. J., Palmer, J., Parveen, N., Patton, S. J., Pease, E. K., Penning, B., Pereira, G., Perry, E., Pershing, J., Piepke, A., Porzio, D., Qie, Y., Reichenbacher, J., Rhyne, C. A., Richards, A., Riffard, Q., Riffard, %Q., Rischbieter, G. R. C., Rosero, R., Rossiter, P., Rushton, T., Santone, D., Sazzad, A. B. M. R., Schnee, R. W., Scovell, P. R., Shaw, S., Shutt, T. A., Silk, J. J., Silva, C., Sinev, G., Smith, R., Solmaz, M., Solovov, V. N., Sorensen, P., Soria, J., Stancu, I., Stevens, A., Stifter, K., Suerfu, B., Sumner, T. J., Swanson, N., Szydagis, M., Taylor, W. C., Taylor, R., Temples, D. J., Terman, P. A., Tiedt, D. R., Timalsina, M., To, W. H., Tong, Z., Tovey, D. R., Trask, M., Tripathi, M., Tronstad, D. R., Turner, W., Utku, U., Vaitkus, A., Wang, B., Wang, Y., Wang, J. J., Wang, W., Watson, J. R., Webb, R. C., White, R. G., Whitis, T. J., Williams, M., Wolfs, F. L. H., Woodford, S., Woodward, D., Wright, C. J., Xia, Q., Xiang, X., Xu, J., and Yeh, M.
Subjects: High Energy Physics - Experiment, Astrophysics - Cosmology and Nongalactic Astrophysics, Astrophysics - Instrumentation and Methods for Astrophysics, High Energy Physics - Phenomenology
Abstract: We estimate the amount of $^{37}$Ar produced in natural xenon via cosmic ray-induced spallation, an inevitable consequence of the transportation and storage of xenon on the Earth's surface. We then calculate the resulting $^{37}$Ar concentration in a 10-tonne payload~(similar to that of the LUX-ZEPLIN experiment) assuming a representative schedule of xenon purification, storage and delivery to the underground facility. Using the spallation model by Silberberg and Tsao, the sea level production rate of $^{37}$Ar in natural xenon is estimated to be 0.024~atoms/kg/day. Assuming the xenon is successively purified to remove radioactive contaminants in 1-tonne batches at a rate of 1~tonne/month, the average $^{37}$Ar activity after 10~tonnes are purified and transported underground is 0.058--0.090~$\mu$Bq/kg, depending on the degree of argon removal during above-ground purification. Such cosmogenic $^{37}$Ar will appear as a noticeable background in the early science data, while decaying with a 35~day half-life. This newly-noticed production mechanism of $^{37}$Ar should be considered when planning for future liquid xenon-based experiments.
Published: 2022
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23. The Relationship of Fractional Exhaled Nitric Oxide in Patients with AECOPD

Author: Xu X, Zhou L, and Tong Z
Subjects: fractional exhaled nitric oxide, chronic obstructive pulmonary disease, acute exacerbation, airway inflammation, Diseases of the respiratory system, RC705-779
Abstract: Xiaoguang Xu,1,2 Lefei Zhou,3 Zhaohui Tong1 1Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-Yang Hospital, Capital Medical University, Beijing, People’s Republic of China; 2Department of Respiratory and Critical Care Medicine, Affiliated Hospital of Jilin Medical University, Jilin, People’s Republic of China; 3Department of Respiratory and Critical Care Medicine, Ordos Central Hospital, Ordos School of Clinical Medicine, Inner Mongolia Medical University, Inner Mongolia, People’s Republic of ChinaCorrespondence: Zhaohui Tong, Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-Yang Hospital, Capital Medical University, No. 8, Gongti South Road, Chaoyang District, Beijing, 100020, People’s Republic of China, Tel +8613089172570, Fax +8601085231217, Email tongzhaohuicy@sina.comObjective: To identify the relationship between patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) and their fractional-exhaled nitric oxide (FeNO) levels.Methods: Patients diagnosed with AECOPD in the respiratory department of Beijing Chaoyang Hospital from June 2017 to August 2019 were recorded. The demographic data, FeNO value, peripheral blood eosinophil count, number of acute exacerbations in the past year, pulmonary function test, use of inhaled glucocorticoids (ICS) and other data were collected and analyzed. FeNO was measured again three months after discharge, the participants were assessed to determine if the stable period criteria were met.Results: A total of 214 patients met the requirements of this study. 25ppb for FeNO was used as the cutoff for further analysis. The proportion of males, number of acute exacerbations in the past year, number of ICS users, leukocyte count and eosinophil count in the high FeNO-level group was significantly higher than that in the low-level group (P < 0.05). The results showed that the number of acute exacerbations in the past year, number of ICS users, and eosinophil count were statistically significant in the model (P < 0.05). The study also showed that the level of FeNO in the acute exacerbation phase was significantly higher than that in the stable phase. The ROC curve that the area under the curve used by FeNO to predict ICS used is 0.631 (95% CI: 0.526– 0.736), and the corresponding P value is 0.022.Conclusion: FeNO is closely related to activated T2 inflammation and eosinophil count in COPD patients. The FeNO levels can be used as an index to evaluate the severity of COPD and predict the recovery of activity after ICS treatment. FeNO can predict the use of ICS and is a beneficial supplement to eosinophils.Keywords: fractional exhaled nitric oxide, chronic obstructive pulmonary disease, acute exacerbation, airway inflammation
Published: 2023

24. The Challenging Path to Diagnosing Extraintestinal Amoebiasis: A Case Report of an HIV-Infected Patient

Author: Li X, Chen C, Tong L, Gao Q, Chen W, Zhou G, Tong Z, and Wang W
Subjects: amebiasis，amoebic abscess，diagnosis，hiv，metagenomic next-generation sequencing，metronidazole, Infectious and parasitic diseases, RC109-216
Abstract: Xiaofeng Li,1,&ast; Cha Chen,1,&ast; Luyuan Tong,1 Qun Gao,1 Wenxian Chen,2 Guangde Zhou,3 Zhaowei Tong,1 Weihong Wang1,4 1Department of Infectious Diseases, Huzhou Central Hospital, Affiliated Central Hospital Huzhou University, Huzhou, Zhejiang Province, People’s Republic of China; 2Department of Ultrasonography, Huzhou Central Hospital, Affiliated Central Hospital Huzhou University, Huzhou, Zhejiang Province, People’s Republic of China; 3Department of Pathology, Affiliated Beijing You An Hospital, Capital Medical University, Beijing, People’s Republic of China; 4Huzhou Key Laboratory of Precision Medicine Research and Translation for Infectious Diseases, Huzhou, Zhejiang Province, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Weihong Wang, Email hzwwh0606@163.comBackground: Amoebiasis, an infectious disease caused by the parasitic protozoan E. histolytica, is easily misdiagnosed due to its declining incidence and atypical symptoms.Case Presentation: A 31-year-old male presented to the hospital with dyspnea and inability to lie flat. Imaging studies indicated a large amount of pleural effusion on the right side and multiple huge cysts in the liver. The patient underwent liver tumor resection surgery at another hospital due to suspected malignancy, but no evidence of relevant malignant tumors was found in the pathological examination. Subsequently, we performed metagenomic next-generation sequencing on the liver drainage fluid and obtained liver pathology slides from the hospital where the surgery was performed at that time. Both of them confirmed the diagnosis of amoebic infection. Empirical treatment with metronidazole was initiated before the diagnosis was confirmed, along with symptomatic treatments such as thoracic drainage and liver drainage. Eventually, the patient’s condition improved and he was discharged smoothly.Conclusion: In order to avoid misdiagnosis of amoebiasis, thoroughly inquiring about the patient’s medical history, shifting perspectives and continuing investigating are necessary when one diagnostic approach proves ineffective. Besides, interdisciplinary collaboration and persistent efforts are crucial for accurate diagnosis.Keywords: amebiasis, amoebic abscess, diagnosis, HIV, metagenomic next-generation sequencing, metronidazole
Published: 2023

25. Association of Blood Inflammatory Biomarkers with Clinical Outcomes in Patients with AECOPD: An 8-Year Retrospective Study in Beijing

Author: Shao S, Zhang Z, Feng L, Liang L, and Tong Z
Subjects: acute exacerbations of chronic obstructive pulmonary disease, neutrophil–lymphocyte ratio, mortality, inflammatory biomarkers, readmission rate, treatment failure rate, Diseases of the respiratory system, RC705-779
Abstract: Shuai Shao,1,&ast; Zhijin Zhang,1,&ast; Lin Feng,2 Lirong Liang,2 Zhaohui Tong1 1Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100020, People’s Republic of China; 2Department of Clinical Epidemiology, Beijing Institute of Respiratory Medicine and Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100020, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Zhaohui Tong, Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine, Beijing Chao-Yang Hospital, Capital Medical University, NO. 8, Gong Ti South Road, Chao-Yang District, Beijing, 100020, People’s Republic of China, Email tongzhaohuicy@sina.comPurpose: To discover potential inflammatory biomarkers, which can compare favorably with traditional biomarkers, and their best cut-offs at first admission to predict clinical outcomes (short-term and long-term) and the risk of readmission among acute exacerbations of chronic obstructive pulmonary disease (AECOPD) patients.Patients and Methods: Novel inflammatory biomarkers (such as the neutrophil–lymphocyte ratio [NLR], platelet–lymphocyte ratio [PLR], etc.) were compared with traditional biomarkers by Pearson’s correlation test. Logistic regression analysis and receiver operating characteristic (ROC) curves were applied to judge the accuracy of these novel biomarkers to predict in-hospital mortality.Results: Surviving AECOPD patients had lower NLR, PLR, and lymphocyte-to-monocyte ratios than non-survival patients (all P < 0.001). According to Pearson’s correlation test, there was a linear correlation between novel and traditional biomarkers (all P < 0.05). In terms of a single biomarker, the AUC value of NLR was the largest, which was not inferior to C-reactive protein (Z-P = 0.064), and superior to erythrocyte sedimentation rate (Z-P = 0.002) and other novel single inflammatory biomarkers (all Z-P < 0.05). The mortality of patients with NLR ≥ 4.43 was 2.308-fold higher than that of patients with NLR < 4.43. After dividing patients into a higher or lower NLR group, pooled results showed that patients with NLR ≥ 4.43 had a higher rate of treatment failure, intensive care unit admission, longer hospital length of stay, one-year mortality after the index hospitalization, and overall mortality than patients with NLR < 4.43 (all P < 0.001). Patients with NLR ≥ 4.43 were associated with higher and earlier first readmission due to AECOPD than patients with lower NLR.Conclusion: NLR was the best to forecast the clinical prognosis and readmission risk among AECOPD patients, which was not inferior to CRP, and the best cut-off value of NLR was 4.43.Keywords: acute exacerbations of chronic obstructive pulmonary disease, neutrophil–lymphocyte ratio, mortality, inflammatory biomarkers, readmission rate, treatment failure rate
Published: 2023

26. The Prognostic Value of Blood Eosinophil Level in AECOPD is Influenced by Corticosteroid Treatment During Hospitalization

Author: Li J, Liang L, Feng L, Cao S, Cai YS, Li X, Qian Z, Brightling CE, and Tong Z
Subjects: chronic obstructive pulmonary disease, eosinophilic inflammation, glucocorticoids, interaction, Pathology, RB1-214, Therapeutics. Pharmacology, RM1-950
Abstract: Jiachen Li,1 Lirong Liang,1 Lin Feng,1 Siyu Cao,2 Yutong Samuel Cai,3 Xiaobo Li,4 Zhenbei Qian,2 Christopher E Brightling,5 Zhaohui Tong2 1Department of Clinical Epidemiology, Beijing Institute of Respiratory Medicine and Beijing Chao-Yang Hospital, Capital Medical University, Beijing, People’s Republic of China; 2Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-Yang Hospital, Capital Medical University, Beijing, People’s Republic of China; 3Centre for Environmental Health and Sustainability, Department of Population Health Sciences, University of Leicester, Leicester, UK; 4Beijing Key Laboratory of Environmental Toxicology, School of Public Health, Capital Medical University, Beijing, People’s Republic of China; 5Institute for Lung Health, NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UKCorrespondence: Lirong Liang, Department of Clinical Epidemiology, Beijing Institute of Respiratory Medicine and Beijing Chao-Yang Hospital, Capital Medical University, No. 8 Gongren Tiyuchang Nanlu, Chaoyang District, Beijing, 100020, People’s Republic of China, Tel +86 010-85231547, Email llrcruie@163.comPurpose: Blood eosinophil is a promising biomarker for phenotyping patients with acute exacerbation of COPD (AECOPD). We aimed to evaluate the prognostic value of eosinophil on short- and long-term outcomes stratified by corticosteroid treatment among AECOPD inpatients.Patients and Methods: In this retrospective cohort study, we included patients hospitalized for AECOPD from July 2013 to June 2021 in Beijing, China. Clinical data were collected from electronic medical records. The blood eosinophil count was measured within 24h after admission. Eosinophilic AECOPD was defined as having an eosinophil percentage ≥ 2%. The study outcomes were length of stay (LOS), treatment failure, and AECOPD readmission risk within 3 years of discharge. Multivariable models were used to analyze the associations between blood eosinophil count and outcomes stratified by corticosteroid treatment during hospitalization.Results: A total of 2406 AECOPD patients were included. The median LOS of AECOPD patients was 10 (interquartile range: 8– 14) days. The eosinophil percentage was negatively associated with LOS (P-trend=0.014). Compared with the non-eosinophilic AECOPD group, the eosinophilic group had a 58% lower risk of treatment failure (OR=0.42, 95% CI: 0.20– 0.89) in patients treated with systemic corticosteroids, but no association was observed in those treated with inhaled corticosteroids (ICS) only (OR=0.95, 95% CI: 0.60– 1.52). The eosinophilic group had an increased risk of 90-day re-admission in patients treated with ICS only (HR=1.51, 95% CI: 1.00– 2.29), but not in patients treated with systemic corticosteroids during hospitalization (HR=0.67, 95% CI: 0.39– 1.15). No statistically significant results were found for 180-day, 1-year, or 3-year readmission risk.Conclusion: Elevated blood eosinophils in AECOPD were associated with shorter length of stay and improved response to treatment with systemic corticosteroids, but not inhaled corticosteroids. Our study suggested that a therapeutic approach of using systemic corticosteroid may benefit patients present with eosinophilic AECOPD.Keywords: chronic obstructive pulmonary disease, eosinophilic inflammation, glucocorticoids, interaction
Published: 2023

27. Frailty Is a Risk Factor for Falls in the Older Adults: A Systematic Review and Meta-Analysis

Author: Yang, Z.-C., Lin, H., Jiang, G.-H., Chu, Y.-H., Gao, J.-H., Tong, Z.-J., and Wang, Zhi-hao
Published: 2023
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28. Multiphase Flows in Pharmaceutical Applications

Author: Tong, Z. B., Yang, R. Y., Chan, H. K., Yu, A. B., Yeoh, Guan Heng, editor, and Joshi, Jyeshtharaj B., editor
Published: 2023
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29. Reply to the Letter to the Editor “Frailty Is a Risk Factor for Falls in the Older Adults: A Systematic Review and Meta-Analysis”

Author: Yang, Z.-C., Lin, H., Jiang, G.-H., Chu, Y.-H., Gao, J.-H., Tong, Z.-J., and Wang, Zhi-hao
Published: 2023
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30. Implementing the Rabat Commitment : the development of Intercultural Communicative Competence (ICC) as a pedagogical framework in a Chinese educational context

Author: Tong, Z., Meier, G., and Dillon, J.
Subjects: 370.951, intercultural competence, intercultural education, intercultural communicative competence, education policy, College English, Chinese higher education
Abstract: Globalization has led to an increasingly interconnected and integrated world on a scale unparalleled in human history. The convergence of cultures and civilizations within this ever-shrinking world is contrasted with the emergence of entities and ideologies that seek to diverge from this common thread of humanity, to dam the tide of globalization in their aspirations to return to nostalgic perceptions of ways before; the world may have become smaller, but it has become ever more fractious. Developing intercultural education through ICC remains at the forefront of both international and national policy agendas: from the United Nations to the Chinese Government, the need to implement ICC within institutions and classrooms and the pressing need to produce interculturally-competent individuals have become key determinants in driving educational policies and guidelines, from the Sustainable Development Goals to the Education 2030 Agenda, from the Community of Shared Future for Mankind to the Belt and Road Initiative. This thesis aims to examine the potential of a Chinese University to develop and implement ICC within the context of English as a foreign language courses for Chinese undergraduate students primarily majoring in STEM fields. This research aims to establish understandings of the current state of intercultural education in China, including policy, theory, and practice – which would yield insights on how ICC is conceptualized and potentially implemented by stakeholders within the Chinese higher educational sector. Using an exploratory-triangulation design, both qualitative and quantitative data were collected from one Chinese Double-First Class University. Findings were analyzed and triangulated to form a comprehensive picture of practical perspectives pertaining to intercultural education, which were subsequently compared with current political and theoretical conceptualizations of both ICC and the interculturally-competent learner. Findings and subsequent analysis show that within the Chinese context via College English courses, ICC development is both feasible and implementable, despite areas where Chinese understandings of intercultural competence have diverged substantially from established Anglophone models and assumptions. Realization of the potential for ICC within Chinese higher education requires adaptation of current models and assumptions of ICC to the realities of the Chinese higher educational context, including the transformation of prevailing models into actionable frameworks for real-world implementation in the College English classroom.
Published: 2020

31. THERMAL BOUNDARY EFFECT ON THE HEAT TRANSFER PERFORMANCE OF A RIBBED COOLING CHANNEL WITH INTERSECTING RIBS

Author: Zhang, C., Wang, W. W., and Tong, Z. T.
Published: 2022
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32. Exosomal miR-133a-3p Derived from BMSCs Alleviates Cerebral Ischemia-Reperfusion Injury via Targeting DAPK2

Author: Yang X, Xu J, Lan S, Tong Z, Chen K, Liu Z, and Xu S
Subjects: ci/r, bmsc, mir-133a-3p, dapk2, autophagy, Medicine (General), R5-920
Abstract: Xuanyong Yang,1,* Jiang Xu,1,* Shihai Lan,1 Zhigao Tong,1 Kang Chen,1 Zhizheng Liu,1 Shan Xu2 1Department of Neurosurgery, The First Affiliated Hospital, Nanchang University, Nanchang, People’s Republic of China; 2Department of Pathology, The First Affiliated Hospital of Nanchang University, Nanchang, People’s Republic of China*These authors contributed equally to this workCorrespondence: Shan Xu, Department of Pathology, The First Affiliated Hospital of Nanchang University, No. 17 Yong Wai Street, Nanchang, Jiangxi, 330006, People’s Republic of China, Email xshan2002@126.comBackground: Cerebral ischemia-reperfusion (CI/R) injury is a subtype of complication after treatment of ischemic stroke. It has been reported that exosomes derived from BMSCs could play an important role in CI/R injury. However, whether BMSCs-derived exosomes could regulate CI/R injury via carrying miRNAs remains to be further explored.Methods: RNA sequencing was performed to identify the differentially expressed miRNAs. To mimic CI/R in vitro, SH-SY5Y cells were exposed to oxygen glucose deprivation/reoxygenation (OGD/R). The viability of SH-SY5Y cells was tested by CCK8 assay, and TUNEL staining was performed to detect the cell apoptosis.Results: MiR-133a-3p was identified to be reduced in exosomes derived from the plasma of patients with IS. Upregulation of miR-133a-3p significantly reversed OGD/R-induced SH-SY5Y cell growth inhibition. Consistently, BMSCs-derived exosomal miR-133a-3p could restore OGD/R-decreased SH-SY5Y cell proliferation via inhibiting apoptosis. Meanwhile, DAPK2 was a direct target of miR-133a-3p. In addition, OGD/R notably upregulated the level of DAPK2 and weakened the expressions of p-Akt and p-mTOR in SH-SY5Y cells, whereas exosomal miR-133a-3p derived from BMSCs notably reversed these phenomena. Exosomal miR-133a-3p derived from BMSCs could reverse OGD/R-induced cell apoptosis via inhibiting autophagy. Furthermore, exosomal miR-133a-3p derived from BMSCs markedly alleviated the symptom of CI/R injury in vivo.Conclusion: Exosomal miR-133a-3p derived from BMSCs alleviates CI/R injury via targeting DAPK2/Akt signaling. Thus, our study might shed new light on discovering new strategies against CI/R injury.Keywords: CI/R, BMSC, miR-133a-3p, DAPK2, autophagy
Published: 2023

33. Eggs Consumption in Relation to Lower Risk of Cognitive Impairment in Elderly: Findings from a 6-Year Cohort Study

Author: Li, F. D., Tong, Z. D., Chang, Y., Li, K. F., Gu, X., Zhang, T., and Lin, Junfen
Published: 2022
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34. Electronic and phononic origins of BaSO4 as an ultra-efficient radiative cooling paint pigment

Author: Tong, Z., Peoples, J., Li, X., Yang, X., Bao, H., and Ruan, X.
Published: 2022
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35. Nomograms for Death from Pneumocystis jirovecii Pneumonia in HIV-Uninfected and HIV-Infected Patients

Author: Feng Q, Hao J, Li A, and Tong Z
Subjects: pneumocystis jirovecii pneumonia, nomogram, hiv, hiv-uninfected, mortality, Medicine (General), R5-920
Abstract: Qiuyue Feng,1,2 Jingjing Hao,3 Ang Li,3 Zhaohui Tong1 1Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine, Beijing Chaoyang Hospital, Capital Medical University, Beijing, 100020, People’s Republic of China; 2Department of Respiratory Medicine, Beijing Huairou Hospital, Beijing, 101400, People’s Republic of China; 3Department of Critical Care Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing, 100015, People’s Republic of ChinaCorrespondence: Zhaohui Tong, Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine, Beijing Chaoyang Hospital, Capital Medical University, Beijing, 100020, People’s Republic of China, Email tongzhaohuicy@sina.com Ang Li, Department of Critical Care Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing, 100015, People’s Republic of China, Email liang@ccmu.edu.cnPurpose: Pneumocystis jirovecii pneumonia (PCP) is a major cause of death in immunocompromised patients. Many risk factors for poor prognosis have been reported, but few studies have created predictive models with these variables to calculate the death rate accurately. This study created nomogram models for the precise prediction of mortality risk in human immunodeficiency virus (HIV) uninfected and HIV-infected patients with PCP.Patients and Methods: A retrospective study was performed over a 10-year period to evaluate the clinical characteristics and outcomes of PCP in HIV-uninfected and HIV-infected adults treated in Beijing, China from 2010 to 2019. Univariate and multivariate logistic regression analyses were used to identify mortality risk factors to create the nomograms. Nomogram models were evaluated by using a bootstrapped concordance index, calibration plots and receiver operating characteristic (ROC) curves.Results: A total of 167 HIV-uninfected and 193 HIV-infected PCP patients were included in the study. Pneumothorax, duration of fever after admission, CD4+ T cells ≤ 100/μL and trimethoprim-sulfamethoxazole (TMP-SMX) combined with caspofungin (CAS) treatment were independent risk factors for death in HIV-uninfected PCP patients. We derived a well calibrated nomogram for mortality by using these variables. The area under the curve was 0.865 (95% confidence interval 0.799– 0.931). Independent risk factors for death in HIV-infected PCP patients were pneumothorax, platelet (PLT) ≤ 80× 109/L, haemoglobin (HGB) ≤ 90 g/L, albumin (ALB), cytomegalovirus (CMV) coinfection and TMP-SMX combined with CAS treatment. The nomogram showed good discrimination, with a C-index of 0.904 and excellent calibration.Conclusion: The nomograms which were derived may be useful tools for the precise prediction of mortality in HIV-uninfected and HIV-infected patients, but require validation in clinical practice.Keywords: Pneumocystis jirovecii pneumonia, nomogram, HIV, HIV-uninfected, mortality
Published: 2022

36. Study on a new process and its kinetics of iron recovery and glass-ceramics preparation from desulfurization slag

Author: Tong Z.-B., Sun J.-T., Liu S.-C., Zhang W., and Kuang M.-L.
Subjects: desulfurization slag, glass-ceramics, diopside and nepheline, kinetics, factsage, Mining engineering. Metallurgy, TN1-997
Abstract: This paper creatively proposes a new process with desulfurization slag leached by ammonium chloride as pretreatment, and the main point of this paper lies in the processing of desulfurization residue leached by ammonium chloride. Through component analysis the formula is adjusted with high aluminum coal ash and glass cullet, making the melting point of the reduction slag around 1200℃, which facilitates the separation of iron and slag. At the same time, the reduction slag is adjusted to the target crystallization phase, so that the high temperature reduction slag after carbon thermal reduction can be used to produce glass-ceramics directly. The results show that iron recovery rate is over 99%, and diopside and nepheline glass-ceramics are produced, which shows that the new process is feasible. However, the crystal growth index is less than 3, which means that the crystallization capacity of the glass-ceramics is low, and nucleating agent is needed in the preparation of glass-ceramics.
Published: 2022
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37. Optimization of geometric parameters of cylindrical film cooling hole with contoured craters to enhance film-cooling effectiveness

Author: Bai, L. C., Zhang, C., Tong, Z. T., and Ju, P. F.
Published: 2021
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38. Dynamic Nomogram for Predicting Thrombocytopenia in Adults with Acute Pancreatitis

Author: Deng H, Yu X, Gao K, Liu Y, Tong Z, and Li W
Subjects: acute pancreatitis, thrombocytopenia, systemic inflammatory response syndrome, coagulopathy, nomogram, Pathology, RB1-214, Therapeutics. Pharmacology, RM1-950
Abstract: Hongbin Deng,1,&ast; Xianqiang Yu,2,&ast; Kun Gao,1 Yang Liu,3 Zhihui Tong,1 Yuxiu Liu,1 Weiqin Li1– 3 1Department of Critical Care Medicine, Jinling Hospital, Nanjing Medical University, Nanjing, People’s Republic of China; 2School of Medicine, Southeast University, Nanjing, People’s Republic of China; 3Department of Critical Care Medicine, Jinling Hospital, Medical School of Nanjing University, Nanjing, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Weiqin Li; Yuxiu Liu Email liweiqindr@nju.edu.cn; Liu_yuxiu@163.comObjective: Thrombocytopenia increases the risk of hemorrhage in patients with acute pancreatitis (AP), leading to poor clinical outcomes. Currently, there is no reliable tool for the early assessment of thrombocytopenia in these patients. We aimed to develop a nomogram based on available clinical parameters and validate its efficacy in predicting thrombocytopenia.Methods: This was a retrospective study. All the data were extracted from an electronic database from May 2018 to May 2019. Patients with a diagnosis of AP and staying in the intensive care unit for more than 3 days were retrospectively analyzed. A clinical signature was built based on reproducible features, using the least absolute shrinkage and selection operator method (LASSO), and logistic regression established the model (P < 0.05). Nomogram performance was determined by its discrimination, calibration, and clinical usefulness.Results: A total of 594 eligible patients were enrolled, of whom 399 were allocated to the training sets and the 195 in the test sets. The clinical features, including blood urea nitrogen (BUN), fibrinogen (FIB), and antithrombase III, were significantly associated with the incidence of thrombocytopenia after acute pancreatitis (p < 0.05) in training sets. The individualized nomogram showed good discrimination in the training sample (area under the receiver operating characteristic curve [AUC], 0.881) and in the validation sample (AUC, 0.883) with good calibration.Conclusion: The proposed nomogram has good performance for predicting thrombocytopenia in patients with acute pancreatitis and may facilitate clinical decision-making.Keywords: acute pancreatitis, thrombocytopenia, systemic inflammatory response syndrome, coagulopathy, nomogram
Published: 2021

39. Moses 2.0 Technology for holmium laser enucleation of the prostate in the treatment of BPH: Prospective randomized double-blind study

Author: Sun, J., primary, Xia, S., additional, Tricard, T., additional, Tong, Z., additional, and Chen, B., additional
Published: 2024
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40. Adherence to Non-Selective Beta Blockers for Prevention of Variceal Bleeding in Cirrhotic Patients

Author: An Y, Xu X, Ren T, Tong Z, Romeiro FG, Mancuso A, Guo X, and Qi X
Subjects: liver cirrhosis, esophageal varices, non-selective beta blockers, adherence, risk factors, Medicine (General), R5-920
Abstract: Yang An,1– 3,&ast; Xiangbo Xu,1– 3,&ast; Tianshu Ren,1– 3,&ast; Zhenhua Tong,1,4,&ast; Fernando Gomes Romeiro,5 Andrea Mancuso,6 Xiaozhong Guo,1 Xingshun Qi1 1Liver Cirrhosis Study Group, Department of Gastroenterology, General Hospital of Northern Theater Command, Shenyang, 110840, People’s Republic of China; 2Postgraduate College, Shenyang Pharmaceutical University, Shenyang, 110016, People’s Republic of China; 3Department of Pharmacy, General Hospital of Northern Theater Command, Shenyang, 110840, People’s Republic of China; 4Section of Medical Service, General Hospital of Northern Theater Command, Shenyang, 110840, People’s Republic of China; 5Department of Internal Medicine, Botucatu Medical School, UNESP – Univ Estadual Paulista. Av. Prof. Mário Rubens Guimarães Montenegro, s/n Distrito de Rubião Jr, Botucatu, Brazil; 6Medicina Interna 1, ARNAS-Civico, Di Cristina-Benfratelli, Palermo, Italy&ast;These authors contributed equally to this workCorrespondence: Xingshun Qi; Xiaozhong Guo Email xingshunqi@126.com; guo_xiao_zhong@126.comBackground and Aim: Long-term use of non-selective beta blockers (NSBBs) is essential for the prevention of esophageal variceal bleeding in liver cirrhosis but may impair the patient’s adherence. The present study aimed to investigate the adherence to NSBBs to prevent variceal bleeding in cirrhotic patients.Methods: All patients who had an indication of NSBBs for the prophylaxis of variceal bleeding between February 2018 and June 2019 were screened. Clinical pharmacists gave pre-medication education and recorded the adherence to NSBBs during the patients’ hospitalizations. Factors associated with poor adherence were evaluated by univariate logistic regression analysis. Odds ratios (OR) with 95% confidence intervals (CI) were calculated. The relationship between poor adherence during follow-up and variceal bleeding after discharge was also evaluated.Results: Overall, 108 patients were screened, of whom 12 were intolerant to NSBBs. Among the 96 remaining patients who could take NSBBs, the average change of heart rate after NSBBs was − 10.49 b.p.m. Twenty-two (22.9%) patients had poor adherence to NSBBs due to their refusal to take NSBBs (n = 2), complete forgetfulness to take NSBBs (n = 10), and refusal or forgetfulness to monitor heart rate (n = 10). Univariate logistic regression analysis demonstrated that only older age was significantly associated with poor adherence (OR: 1.065, 95% CI: 1.019– 1.114, P = 0.005). Patients with poor adherence during follow-up were more likely to develop variceal bleeding after discharge.Conclusion: A significant proportion of cirrhotic patients had poor adherence to NSBBs during their hospitalizations. Further studies should explore how to improve the patient’s adherence to NSBBs.Keywords: liver cirrhosis, esophageal varices, non-selective beta blockers, adherence, risk factors
Published: 2021

41. Risk Factors Associated with Invasive Pulmonary Mycosis Among Severe Influenza Patients in Beijing City, China

Author: Guo M and Tong Z
Subjects: influenza, invasive pulmonary mycosis, infection, hospitalization, incidence rate, Medicine (General), R5-920
Abstract: Maoqing Guo, Zhaohui Tong Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine, Beijing Chao‐Yang Hospital, Capital Medical University, Beijing, 100020, People’s Republic of ChinaCorrespondence: Zhaohui TongDepartment of Respiratory and Critical Care Medicine, Beijing Chao‐Yang Hospital, Capital Medical University, Beijing, 100020, People’s Republic of ChinaEmail tongzhaohuicy@sina.comObjective: Influenza co-infection with fungal infection increases the risk of death. Our study was to estimate risk factors associated with invasive pulmonary mycosis (IPM) among severe influenza patients at a single center in Beijing, China.Methods: A retrospective chart review was carried out of all patients with severe influenza admitted to respiratory the department including the respiratory intensive care unit (RICU) during the 2014 to 2019 influenza seasons in Beijing Chao-yang hospital, China. We compared the differences of characteristics and examination outcomes between IPM patients and non-IPM patients, and explored the predictors of IPM by a multivariate logistic regression.Results: Influenza associated IPM was found in 65 of 131 (49.62%) patients. The average age of IPM patients was 57.28± 14.56 years and 70.77% were male. The mortality rate was much higher in the IPM group than the non-IPM group (34.85% versus 18.46%, P=0.026). Older age, hypoimmunity, liver disease, hypertension, positive serum GM test, steroids using, gasping, gastrointestinal symptoms, high APECHEII, low oxygenation index, other viruses co-infection, bacterial co-infection, low lymphocyte counts, low CD4+ T-cell counts, low CD8+ T-cell counts, low RBC, low hemoglobin, low platelets, high N%, low total protein, high CRP, low albumin, low fibrinogen, high BUN, positive serum GM test, more mechanical ventilation requirement, and more renal replacement requirement were risk factors of influenza IPM co-infection.Conclusion: IPM is a severe complication of influenza hospitalizations. It is associated with increasing mortality, longer hospital stays, and higher hospital charges compared with non-IPM patients. Clinicians caring for patients with severe influenza should consider IPM.Keywords: influenza, invasive pulmonary mycosis, infection, hospitalization, incidence rate
Published: 2021

42. Immune Dysfunction is Associated with Readmission in Survivors of Sepsis Following Infected Pancreatic Necrosis

Author: Yin J, Mao W, Xiao X, Yu X, Li B, Chen F, Lin J, Zhou J, Tong Z, Ke L, and Li W
Subjects: infected pancreatic necrosis, sepsis, immunosuppression, monocyte hla-dr, readmissions, Pathology, RB1-214, Therapeutics. Pharmacology, RM1-950
Abstract: Jiangtao Yin,1,2,&ast; Wenjian Mao,1,&ast; Xiaojia Xiao,3 Xianqiang Yu,4 Baiqiang Li,5 Faxi Chen,5 Jiajia Lin,5 Jing Zhou,1 Jing Zhou,4 Zhihui Tong,5 Lu Ke,5 Weiqin Li1,5 1Department of Critical Care Medicine, Jinling Hospital, Nanjing Medical University, Nanjing, People’s Republic of China; 2Department of Intensive Care Unit, Affiliated Hospital of Jiangsu University, Zhenjiang, People’s Republic of China; 3Department of Critical Care Medicine, Jinling Hospital of Southern Medical University, Nanjing, People’s Republic of China; 4Southeast University School of Medicine, Nanjing, People’s Republic of China; 5Department of Critical Care Medicine, Jinling Hospital, Nanjing University, Nanjing, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Lu Ke; Weiqin LiDepartment of Critical Care Medicine, Jinling Hospital, Medical School of Nanjing University, 305 East Zhongshan Road, Nanjing, 225001, People’s Republic of ChinaEmail ctgkelu@nju.edu.cn; njzy_pancrea@163.comObjective: Immunosuppression is common in patients with infected pancreatic necrosis (IPN) and associated with morbidity and mortality. This study aimed to investigate the impact of immune status on mortality and readmission after hospital discharge in patients with IPN-related sepsis.Methods: In this prospective observational study, eligible adult patients with IPN-related sepsis requiring ICU admission were included. Monocytic human leukocyte antigen DR (mHLA-DR), expression of regulatory T cells (Treg), and neutrophil CD88 (nCD88) were measured on the diagnosis of sepsis, ICU discharge, hospital discharge, and 15, 30, 60 days after hospital discharge. Logistic regression model was used to assess potential risk factors for readmission 60-days within the index discharge.Results: A total of 53 patients were included, 13 died during hospitalization and one withdrew the consent soon after discharge. Among the survivors, a tendency of immune recovery was observed during the consecutive follow-ups, evidenced by the increased expression of mHLA-DR. Sixteen patients (41.03%) were readmitted within 60 days after the index discharge. In the multivariable regression model, APACHE II score when sepsis was diagnosed > 9 and mHLA-DR at discharged < 14,591 AB/C were found to be independent risk factors affecting readmission.Conclusion: Immunosuppression is common in patients with IPN-related sepsis and can persist until two months after discharge. The compromised mHLA-DR level at discharge was associated with readmission within two months after discharge.Keywords: infected pancreatic necrosis, sepsis, immunosuppression, monocyte HLA-DR, readmissions
Published: 2021

43. Step-by-Step Construction of Gene Co-Expression Network Analysis for Identifying Novel Biomarkers of Sepsis Occurrence and Progression

Author: Yu X, Qu C, Ke L, Tong Z, and Li W
Subjects: sepsis, gene co-expression network, biomarker, immune cell, Medicine (General), R5-920
Abstract: Xianqiang Yu,1,&ast; Cheng Qu,2,&ast; Lu Ke,2 Zhihui Tong,2 Weiqin Li1,2 1Medical School, Southeast University, Nanjing, People’s Republic of China; 2Department of Critical Care Medicine, Jinling Hospital, Medical School of Nanjing University, Nanjing, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Weiqin Li Email liweiqindr@nju.edu.cnBackground: Sepsis is the leading cause of death in critically ill patients. Although it is well known that the immune system plays a key role in sepsis, exactly how it works remains unknown.Methods: In our study, we used weighted gene co-expression network analysis (WGCNA) to screen out the immune-related genes that may play a critical role in the process of sepsis.Results: A total of three sepsis-related hub genes were screened for further verification. Subsequent analysis of immune subtypes suggested their potential predictive effect in the clinic.Conclusion: Our study shows that three immune-related genes CHMP1A, MED15 and MGAT1 are important biomarkers of sepsis. The screened genes may help to distinguish normal individuals from patients with different degrees of sepsis.Keywords: sepsis, gene co-expression network, biomarker, immune cell
Published: 2021

44. Final results from the PERUSE study of first-line pertuzumab plus trastuzumab plus a taxane for HER2-positive locally recurrent or metastatic breast cancer, with a multivariable approach to guide prognostication

Author: Bachelot, T., Bouzid, K., Campone, M., Desmoulins, I., Coudert, B., Bondarenko, I., Nowecki, Z., Glogowska, I., Ciruelos Gil, E., Errihani, H., Dalenc, F., Ricci, F., Dieras, V., Kaufman, B., Paluch-Shimon, S., Wardley, A., Schneeweiss, A., Ferreira, A., Mano, M., Kalofonos, H., Andreetta, C., Puglisi, F., Montemurro, F., Barrett, S., Zhang, Q., Mavroudis, D., Matus, J., Villarreal Garza, C., Beato, C., Ismael, G., Hu, X., Abdel Azeem, H., Gaafar, R., Perrin, C., Kerbrat, P., Ettl, J., Paepke, S., Hitre, E., Lang, I., Trudeau, M., Verma, S., Li, H., Hoffmann, O., Aktas, B., Cariello, A., Cruciani, G., Tienghi, A., Tondini, C., Al-Twegieri, T., Loman, N., Laing, R., Miles, D., Brain, E., Fasching, P., Lux, M., Frassoldati, A., Aziz, Z., Salas, J., Streb, J., Krzemieniecki, K., Wronski, A., Garcia Garcia, J., Menjon Beltran, S., Cicin, I., Schmid, P., Gallagher, C., Turner, N., Tong, Z., Boer, K., Juhász, B., Horvath, Z., Bianchini, G., Gianni, L., Curigliano, G., Juarez Ramiro, A., Susnjar, S., Matos, E., Sevillano, E., Garcia Estevez, L., Gokmen, E., Uslu, R., Wildiers, H., Schutz, F., Cruz, M., Bourgeois, H., von Schumann, R., Stemmer, S., Dominguez, A., Morales-Vásques, F., Wojtukiewicz, M., Trifunovic, J., Echarri Gonzalez, M.J., Illarramendi Mañas, J., Martinez De Dueñas, E., Voitko, N., Hicks, J., Waters, S., Barrett-Lee, P., Wheatley, D., De Boer, R., Cocquyt, V., Jerusalem, G., Barrios, C., Panasci, L., Mattson, J., Tanner, M., Gozy, M., Vasilopoulos, G., Papandreou, C., Revesz, J., Battelli, N., Benedetti, G., Latini, L., Gridelli, C., Lazaro Leon, J., Alarcón Company, J., Arance Fernandez, A., Barnadas Molins, A., Calvo Plaza, I., Bratos, R., Gonzalez Martin, A., Izarzugaza Peron, Y., Klint, L., Kovalev, A., McCarthy, N., Yeo, B., Kee, D., Thomson, J., White, S., Greil, R., Wang, S., Artignan, X., Juhasz-Böess, I., Rody, A., Ngan, R., Dourleshter, F., Goldberg, H., Doni, L., Di Costanzo, F., Ferraù, F., Drobniene, M., Aleknavicius, E., Rashid, K., Costa, L., de la Cruz Merino, L., Garcia Saenz, J., López, R., Del Val Munoz, O., Ozyilkan, O., Azribi, F., Jaafar, H., Baird, R., Verrill, M., Beith, J., Petzer, A., Moreira de Andrade, J., Bernstein, V., Macpherson, N., Rayson, D., Saad Eldin, I., Achille, M., Augereau, P., Müller, V., Rasco, A., Evron, E., Katz, D., Berardi, R., Cascinu, S., De Censi, A., Gennari, A., El-Saghir, N., Ghosn, M., Oosterkamp, H.M., Van den Bosch, J., Kukulska, M., Kalinka, E., Alonso, J., Dalmau Portulas, E., Del Mar Gordon Santiago, M., Pelaez Fernandez, I., Aksoy, S., Altundag, K., Senol Coskun, H., Bozcuk, H., Shparyk, Y., Barraclough, L., Levitt, N., Panwar, U., Kelly, S., Rigg, A., Varughese, M., Castillo, C., Fein, L., Malik, L., Stuart-Harris, R., Singer, C., Stoeger, H., Samonigg, H., Feng, J., Cedeño, M., Ruohola, J., Berdah, J.-F., Goncalves, A., Orfeuvre, H., Grischke, E.-M., Simon, E., Wagner, S., Koumakis, G., Papazisis, K., Ben Baruch, N., Fried, G., Geffen, D., Karminsky, N., Peretz, T., Cavanna, L., Pedrazzioli, P., Grasso, D., Ruggeri, E., D’Auria, G., Moscetti, L., Juozaityte, E., Rodriguez Cid, J., Roerdink, H., Siddiqi, N., Passos Coelho, J., Arcediano Del Amo, A., Garcia Garre, E., García Gonzalez, M., Garcia-Palomo Perez, A., Herenandez Perez, C., Lopez Alvarez, P., Lopez De Ceballos, M.H., Martínez Jañez, N., Mele Olive, M., McAdam, K., Perren, T., Dunn, G., Humphreys, A., Taylor, W., Vera, R., Kaen, L., Andel, J., Steger, G., De Grève, J., Huizing, M., Hegg, R., Joy, A., Kuruvilla, P., Sehdev, S., Smiljanic, S., Kütner, R., Alexandre, J., Grosjean, J., Laplaige, P., Largillier, R., Maes, P., Martin, P., Pottier, V., Christensen, B., Khandan, F., Lück, H.-J., Zahm, D.-M., Fountzilas, G., Karavasilis, V., Safra, T., Inbar, M., Ryvo, L., Bonetti, A., Seles, E., Giacobino, A., Chavarri Guerra, Y., de Jongh, F., van der Velden, A., van Warmerdam, L., Vrijaldenhoven, S., Smorenburg, C.H., Cavero, M., Andres Conejero, R., Oltra Ferrando, A., Redondo Sanchez, A., Ribelles Entrena, N., Saura Grau, S., Viñas Vilaro, G., Bachmeier, K., Beresford, M., Butt, M., Joffe, J., Poole, C., Woodings, P., Chakraborti, P., Yordi, G., Woodward, N., Nobre, A., Luiz Amorim, G., Califaretti, N., Fox, S., Robidoux, A., Li, E., Li, N., Jiang, J., Soria, T., Padrik, P., Lahdenpera, O., Barletta, H., Dohollou, N., Genet, D., Prulhiere, K., Coeffic, D., Facchini, T., Vieillot, S., Catala, S., Teixeira, L., Hesse, T., Kühn, T., Ober, A., Repp, R., Schröder, W., Pectasides, D., Bodoky, G., Kahan, Z., Jiveliouk, I., Rosengarten, O., Rossi, V., Alabiso, O., Pérez Martínez, M., van de Wouw, A.J., Smok-Kalwat, J., Damasecno, M., Augusto, I., Sousa, G., Saadein, A., Abdelhafiez, N., Abulkhair, O., Antón Torres, A., Corbellas Aparicio, M., Llorente Domenech, R., Florián Jerico, J., Garcia Mata, J., Gil Raga, M., Galan Brotons, A., Llombart Cussac, A., Llorca Ferrandiz, C., Martinez Del Prado, P., Olier Garate, C., Rodriguez Sanchez, C., Sanchez Gomez, R., Santisteban Eslava, M., Soberino, J., Vidal Losada Garcia, M., Soto de Prado, D., Torrego Garcia, J., Vicente Rubio, E., Garcia, M., Murias Rosales, A., Granstam Björneklett, H., Narbe, U., Jafri, M., Rea, D., Newby, J., Jones, A., Westwell, S., Ring, A., Alonso, I., Rodríguez, R., Ciruelos, E., Peretz-Yablonski, T., Merot, J.-L., Trask, P., du Toit, Y., Pena-Murillo, C., Revelant, V., and Klingbiel, D.
Published: 2021
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45. Primary results from IMpassion131, a double-blind, placebo-controlled, randomised phase III trial of first-line paclitaxel with or without atezolizumab for unresectable locally advanced/metastatic triple-negative breast cancer

Author: Zhang, Q., Xu, B., Shao, Z., Wang, X., Geng, C., Yan, X., Tong, Z., Shen, K., Yin, Y., Sun, T., Yang, J., Feng, J., Yan, M., Wang, Y., Liu, Q., Zhang, S., De Laurentiis, M., Santoro, A., Guarneri, V., Colleoni, M., Natoli, C., Cortesi, L., Placido, S., Gianni, L., Ferrau, F., Livi, L., Zambelli, A., Del Mastro, L., Tonini, G., Montemurro, F., Bianchi, G., Pedersini, R., Prete, S., Allegrini, G., Naso, G., Vici, P., Loirat, D., Mailliez, A., Priou, F., Tredan, O., Dalenc, F., Perrin, C., Gligorov, J., Timar David, M., Dohollou, N., Teixeira, L., Brocard, F., Arnaud, A., Delaloge, S., Spano, J.-P., Mansi, L., Andrade, L., Damian, F., Pedrini, J., Aleixo, S., Hegg, R., Junior, R., Reinisch, M., Schmidt, M., Wenzel, C., Grischke, E.-M., Schneeweiss, A., Just, M., Harbeck, N., Schumacher, C., Peters, U., Fischer, D., Forstbauer, H., Liersch, R., Warner, E., Bouganim, N., Doyle, C., Price Hiller, J., Vandenberg, T., Pavic, M., Robinson, A., Roldan Urgoiti, G., Califaretti, N., Alacacioglu, A., Gumus, M., Yalcin, B., Cicin, I., Kose, F., Uygun, K., Kaplan, M., Cubukcu, E., Wardley, A., Harries, M., Miles, D., Doval, D., Gupta, S., Mohapatra, P., Chatterjee, S., Ghadyalpatil, N., Singhal, M., Nag, S., Agarwal, A., Wolf, I., Gal Yam, E., Yerushalmi, R., Peretz, T., Fried, G., Ben Baruch, N., Katz, D., Hamilton, E., Kayali, F., Brufsky, A., Telli, M., Wright, G., Oyola, R., Rakowski, T., Graff, S., Tjulandin, S., Semiglazov, V., Aparicio, A., Ruiz Borrego, M., Merino, L., Guerra Martinez, J., Lopez, E., Yamashita, T., Ohtani, S., Inoue, K., Ito, Y., Niikura, N., Nakayama, T., Sagara, Y., Yanagita, Y., Kamada, Y., Kaneko, K., Kaen, D., Nervo, A., Eniu, A., Schenker, M., Priester, P., Melichar, B., Zimovjanova, M., Sormova, P., Sufliarsky, J., Kakalejcik, M., Belbaraka, R., Errihani, H., Le Than, D., Pham, D., Aravantinos, G., Papadimitriou, C., Koumakis, G., Papandreou, C., Podolski, P., Tabane, K., André, F., Cameron, D., Barrios, C., Patel, S., Patre, M., Morales, L., Patel, S.L., Kaul, M., Barata, T., and O’Shaughnessy, J.
Published: 2021
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46. Efficacy of utidelone plus capecitabine versus capecitabine for heavily pretreated, anthracycline- and taxane-refractory metastatic breast cancer: final analysis of overall survival in a phase III randomised controlled trial

Author: Xu, B., Sun, T., Zhang, Q., Zhang, P., Yuan, Z., Jiang, Z., Wang, X., Cui, S., Teng, Y., Hu, X.-C., Yang, J., Pan, H., Tong, Z., Li, H., Yao, Q., Wang, Y., Yin, Y., Sun, P., Zheng, H., Cheng, J., Lu, J., Zhang, B., Geng, C., Liu, J., Shen, K., Yu, S., Tang, L., and Qiu, R.
Published: 2021
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47. Anomalous thermal transport in metallic transition-metal nitrides originated from strong electron–phonon interactions

Author: Li, S., Wang, A., Hu, Y., Gu, X., Tong, Z., and Bao, H.
Published: 2020
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48. Hemodynamic Effects of Conduit Position on Systemic-to-Pulmonary Shunt: A Numerical Study Using Virtual Design

Author: Liu, J. L., Sun, Q., Tong, Z. R., Shen, J. Y., Liu, J. F., Magjarevic, Ratko, Editor-in-Chief, Ładyżyński, Piotr, Series Editor, Ibrahim, Fatimah, Series Editor, Lacković, Igor, Series Editor, Rock, Emilio Sacristan, Series Editor, Lhotska, Lenka, editor, Sukupova, Lucie, editor, and Ibbott, Geoffrey S., editor
Published: 2019
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49. Cysteine Potentiates Bactericidal Antibiotics Activity Against Gram-Negative Bacterial Persisters

Author: Liu Y, Yang K, Jia Y, Shi J, Tong Z, and Wang Z
Subjects: amino acids, bacterial persisters, bactericidal antibiotics, cysteine, gram-negative bacteria, Infectious and parasitic diseases, RC109-216
Abstract: Yuan Liu,1– 3 Kangni Yang,1 Yuqian Jia,1 Jingru Shi,1 Ziwen Tong,1 Zhiqiang Wang1,2 1College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu, People’s Republic of China; 2Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Joint International Research Laboratory of Agriculture and Agri-Product Safety, The Ministry of Education of China, Yangzhou University, Yangzhou, Jiangsu, People’s Republic of China; 3Institute of Comparative Medicine, Yangzhou University, Yangzhou, Jiangsu, People’s Republic of ChinaCorrespondence: Zhiqiang Wang; Yuan Liu Email zqwang@yzu.edu.cn; liuyuan2018@yzu.edu.cnPurpose: Bacterial metabolism regulators offer a novel productive strategy in the eradication of antibiotic refractory bacteria, particularly bacterial persisters. However, the potential of amino acids in the fight against Gram-negative bacterial persisters has not been fully explored. The aim of this study is to investigate the potentiation of amino acids to antibiotics in combating Gram-negative bacterial persisters and to reveal the underlying mechanisms of action.Methods: Bactericidal activity of antibiotics in the absence or presence of amino acids was evaluated through detecting the reduction of bacterial CFUs. The ratio of NAD+/NADH in E. coli B2 persisters was determined using assay kit with WST-8. Bacterial respiration and ROS production were measured by the reduction of iodonitrotetrazolium chloride and fluorescent probe 2′,7′-dichlorodihydrofluorescein diacetate, respectively.Results: In this study, we found that cysteine possesses excellent synergistic bactericidal activity with ciprofloxacin against multiple Gram-negative bacterial persisters. Furthermore, the potentiation of cysteine was evaluated in exponential and stationary-phase E. coli ATCC 25922 and E. coli B2. Interestingly, cysteine significantly improves three bactericidal antibiotics killing against stationary-phase bacteria, but not exponential-phase bacteria, implying that the effect of cysteine correlates with the metabolic state of bacteria. Mechanistic studies revealed that cysteine accelerates the bacterial TCA cycle and promotes bacterial respiration and ROS production. These metabolic regulation effects of cysteine re-sensitive bacterial persisters to antibiotic killing.Conclusion: Collectively, our study highlights the synergistic bactericidal activity of bacterial metabolism regulators such as cysteine with commonly used antibiotics against Gram-negative bacterial persisters.Keywords: amino acids, bacterial persisters, bactericidal antibiotics, cysteine, gram-negative bacteria
Published: 2020

50. Role of TNF-α and FGF-2 in the Fracture Healing Disorder of Type 2 Diabetes Model Induced by High Fat Diet Followed by Streptozotocin

Author: Huang H, Luo L, Liu Z, Li Y, and Tong Z
Subjects: type 2 diabetes mellitus, t2dm rat model, distraction osteogenesis, fracture healing, fgf-2, tnf- α, mc3t3-e1 cells, Specialties of internal medicine, RC581-951
Abstract: Heqing Huang, Ling Luo, Zhitao Liu, Yan Li, Zhaochen Tong, Zhendong Liu Department of Orthopaedics and Traumatology, Third Xiangya Hospital of Central South University, Changsha 410013, Hunan Province, People’s Republic of ChinaCorrespondence: Zhendong LiuDepartment of Orthopaedics and Traumatology, Third Xiangya Hospital of Central South University, No. 138 Tongzipo Road, Changsha 410013, Hunan Province, People’s Republic of ChinaTel/Fax +8673188638888Email liuzhendong001@163.comPurpose: To investigate the effect of TNF-α and FGF-2 in the fracture healing disorder of type 2 diabetes.Design/Methodology/Approach: Rat diabetes-bone traction model was established to investigate the effect of type 2 diabetes on the fracture healing and the association of TNF-α and FGF-2 with the process. Serological examination was performed to detect the related diabetes indexes. The proliferation activity of the cells was detected by MTT assay. The expressions of FGF-2 and TNF-α of osteoblasts in high glucose culture environment were detected by histochemistry and Western blotting.Findings: Serological examination showed that in rats fed with high fat and sugar diet for 8 weeks, the serum total cholesterol (TC), triglyceride (TG), fasting insulin (FINs) significantly increased, but fasting blood glucose (FBG) had no significant change. Two weeks after intraperitoneal injection of STZ, rat serum TG, TC, and FBG increased significantly, while FINs did not change obviously. Two weeks after traction osteogenesis, X-ray examination and HE staining showed that the area of osteotylus in the diabetes group was significantly smaller than that in the control group. The number of PCNA positive cells in the osteotylus of diabetes group was significantly decreased. In the osteotylus of diabetes group, the expression of TNF-α was significantly increased and the expression of FGF-2 was significantly decreased. MTT assay showed that the proliferation activity of MC3T3-E1 cells in high glucose culture medium groups was significantly decreased at 24th hour of the culture, compared with the normal culture medium group. qPCR results showed that the expression of FGF-2 was significantly decreased while the expression of TNF-α was significantly increased in high glucose culture medium groups.Originality/Value: It was concluded that type 2 diabetes mellitus affected the fracture healing by causing osteoblast proliferation disorder. TNF-α and FGF-2 were important related factors for the process.Keywords: type 2 diabetes mellitus, T2DM rat model, distraction osteogenesis, fracture healing, FGF-2, TNF-α, MC3T3-E1 cells
Published: 2020

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