Search

Your search keyword '"Tong, Yigang"' showing total 1,137 results
Start Over Author "Tong, Yigang"
1,137 results on '"Tong, Yigang"'

2. Cepharanthine analogs mining and genomes of Stephania accelerate anti-coronavirus drug discovery

Author

Leng, Liang, Xu, Zhichao, Hong, Bixia, Zhao, Binbin, Tian, Ya, Wang, Can, Yang, Lulu, Zou, Zhongmei, Li, Lingyu, Liu, Ke, Peng, Wanjun, Liu, Jiangning, An, Zhoujie, Wang, Yalin, Duan, Baozhong, Hu, Zhigang, Zheng, Chuan, Zhang, Sanyin, Li, Xiaodong, Li, Maochen, Liu, Zhaoyu, Bi, Zenghao, He, Tianxing, Liu, Baimei, Fan, Huahao, Song, Chi, Tong, Yigang, and Chen, Shilin

Published
2024
Full Text
View/download PDF

12. Perspective on taxonomic classification of uncultivated viruses

Author

Dutilh, Bas E, Varsani, Arvind, Tong, Yigang, Simmonds, Peter, Sabanadzovic, Sead, Rubino, Luisa, Roux, Simon, Muñoz, Alejandro Reyes, Lood, Cédric, Lefkowitz, Elliot J, Kuhn, Jens H, Krupovic, Mart, Edwards, Robert A, Brister, J Rodney, Adriaenssens, Evelien M, and Sullivan, Matthew B

Subjects
Microbiology, Biological Sciences, Animals, Evolution, Molecular, Humans, Metagenomics, Phylogeny, Viruses, Medical Microbiology
Abstract

Historically, virus taxonomy has been limited to describing viruses that were readily cultivated in the laboratory or emerging in natural biomes. Metagenomic analyses, single-particle sequencing, and database mining efforts have yielded new sequence data on an astounding number of previously unknown viruses. As metagenomes are relatively free of biases, these data provide an unprecedented insight into the vastness of the virosphere, but to properly value the extent of this diversity it is critical that the viruses are taxonomically classified. Inclusion of uncultivated viruses has already improved the process as well as the understanding of the taxa, viruses, and their evolutionary relationships. The continuous development and testing of computational tools will be required to maintain a dynamic virus taxonomy that can accommodate the new discoveries.

Published
2021

36. Efficient Broad-Spectrum Cyanophage Function Module Mining.

Author

Guo, Yujing, Dong, Xiaoxiao, Li, Huiying, Lin, Wei, Cao, Lei, Li, Dengfeng, Zhang, Yiming, Jin, Jin, Tong, Yigang, and Liu, Zihe

Abstract

Cyanobacterial harmful algal blooms (CyanoHABs) cause health and environmental effects worldwide. Cyanophage is a virus that exclusively infects cyanobacteria. Using cyanophages to control blooms is the latest biological control method. However, little research on the genomics of cyanophages and the presence of numerous proteins with unidentified functions in cyanophage genomes pose challenges for their practical application and comprehensive investigation. We selected the broad-spectrum and efficient cyanophage YongM for our study. On the one hand, through rational analysis, we analyze essential genes, establish the minimal cyanophage genome and single essential gene modules, and examine the impact of essential modules on growth. Additionally, we conducted ultraviolet mutagenesis on YongM to generate more efficient cyanophages' critical modules through random mutagenesis. Then, we sequenced and analyzed the functionality of the mutational gene modules. These findings highlight several gene modules that contribute to a deeper understanding of the functional components within cyanophage genomes. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

37. vB_CacS-HV1 as a Novel Pahexavirus Bacteriophage with Lytic and Anti-Biofilm Potential against Cutibacterium acnes.

Author

Li, Xu, Ding, Wenyan, Li, Zicheng, Yan, Yi, Tong, Yigang, Xu, Jialiang, and Li, Mengzhe

Abstract

Acne vulgaris is a prevalent chronic inflammatory skin disease, most common in adolescence and often persisting into adulthood, leading to severe physical and psychological impacts. The primary etiological factor is Cutibacterium acnes infection. The overuse of antibiotics for acne treatment over recent decades has led to the emergence of antibiotic-resistant Cutibacterium acnes strains. In this study, we isolated and characterized a novel bacteriophage, vB_CacS-HV1, from saliva samples. The average nucleotide identity analysis indicated that vB_CacS-HV1 is a new species within the Pahexavirus genus, enhancing our understanding of this underexplored group. vB_CacS-HV1 demonstrates favorable stability, lacks potentially harmful genetic elements (virulence factors, antibiotic resistance genes, transposons, and integrases), and exhibits potent lytic and anti-biofilm activities against Cutibacterium acnes at low concentrations. These advantages highlight vB_CacS-HV1's potential as a promising antibacterial agent that could possibly be complementary to antibiotics or other treatments for acne therapy. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results