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25 results on '"Tong, Jinyi"'

19. Circular RNAs: A Promising Biomarker for Endometrial Cancer

Author

Guo,Jialu, Tong,Jinyi, and Zheng,Jianfeng

Subjects
Cancer Management and Research
Abstract

Jialu Guo, 1, 2 Jinyi Tong, 1, 2 Jianfeng Zheng 2, 3 1Department of the Fourth Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, 310008, People’s Republic of China; 2Department of Obstetrics and Gynecology, Hangzhou Women’s Hospital (Hangzhou Maternity and Child Health Care Hospital), Hangzhou, Zhejiang Province, 310008, People’s Republic of China; 3Department of Obstetrics and Gynecology, Affiliated Hangzhou Hospital, Nanjing Medical University, Hangzhou, Zhejiang Province, 310008, People’s Republic of ChinaCorrespondence: Jinyi TongDepartment of the Fourth Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou Women’s Hospital (Hangzhou Maternity and Child Health Care Hospital), Hangzhou, Zhejiang Province, 310008, People’s Republic of ChinaTel +86 13588818180Email tongjinyi252@zju.edu.cnAbstract: Endometrial cancer (EC) is one of the most common malignant tumors of the female reproductive tract. EC patients have high morbidity and mortality rates and remain an important cause of cancer-related morbidity and mortality worldwide. More and more studies have shown that a large number of non-coding RNAs (such as microRNAs and long non-coding RNAs) are associated with the occurrence of diseases. Circular RNAs (circRNAs) is an endogenous non-coding RNA. It has a unique covalent structure. Many studies in recent years have found circRNAs differential expression in a variety of tumor tissues compared to matched normal tissues. In endometrial carcinoma, there also are multiple circRNAs differentially expressed and therefore circRNAs perhaps can be used as a diagnostic and prognosis biomarkers of EC. In this review, we described the biogenesis, function and characteristics of circRNAs, and the circRNAs with potential influence and clinical significance on the development of EC were summarized. Adenocarcinoma is the most common form of EC, so this review focuses on endometrioid adenocarcinoma.Keywords: circRNA, biogenesis, back-splicing, function, endometrial cancer, biomarker

Published
2021

25. Potential Markers to Differentiate Uterine Leiomyosarcomas from Leiomyomas.

Author

Guo J, Zheng J, and Tong J

Subjects
Humans, Female, Diagnosis, Differential, Prognosis, Leiomyoma diagnosis, Leiomyoma pathology, Uterine Neoplasms diagnosis, Uterine Neoplasms pathology, Leiomyosarcoma diagnosis, Leiomyosarcoma pathology, Biomarkers, Tumor
Abstract

Uterine leiomyomas (ULM) are the most common benign tumors of the female genitalia, while uterine leiomyosarcomas (ULMS) are rare. The sarcoma is diffuse growth, prone to hematogenous metastasis, and has a poor prognosis. Due to their similar clinical symptoms and morphological features, it is sometimes difficult to distinguish them, and the final diagnosis depends on histological diagnosis. Misdiagnosis of ULM as ULMS will lead to more invasive and extensive surgery when it is not needed, while misdiagnosis of ULMS as ULM may lead to delayed treatment and poor prognosis. This review searched and studied the published articles on ULM and ULMS, and summarized the potential markers for the differential diagnosis of ULMS. These markers will facilitate differential diagnosis and personalized treatment, providing timely diagnosis and potentially better prognosis for patients., Competing Interests: Competing Interests: The authors have declared that no competing interest exists., (© The author(s).)

Published
2024
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